SPR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* L-phenylalanine metabolic process (GO:0006558)6.55344118
2* erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.55344118
3L-phenylalanine catabolic process (GO:0006559)6.55344118
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.55344118
5aromatic amino acid family catabolic process (GO:0009074)5.89611475
6glyoxylate metabolic process (GO:0046487)5.79642769
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.46605866
8sulfur amino acid catabolic process (GO:0000098)5.45468149
9kynurenine metabolic process (GO:0070189)5.42579127
10cysteine metabolic process (GO:0006534)5.41463651
11tryptophan catabolic process (GO:0006569)5.34318198
12indole-containing compound catabolic process (GO:0042436)5.34318198
13indolalkylamine catabolic process (GO:0046218)5.34318198
14lysine metabolic process (GO:0006553)5.32454651
15lysine catabolic process (GO:0006554)5.32454651
16serine family amino acid catabolic process (GO:0009071)5.28018420
17Golgi transport vesicle coating (GO:0048200)5.09634799
18COPI coating of Golgi vesicle (GO:0048205)5.09634799
19tryptophan metabolic process (GO:0006568)5.00474784
20bile acid biosynthetic process (GO:0006699)4.96379566
21glycine metabolic process (GO:0006544)4.92905605
22urea cycle (GO:0000050)4.90272437
23urea metabolic process (GO:0019627)4.90272437
24negative regulation of fibrinolysis (GO:0051918)4.87440126
25homocysteine metabolic process (GO:0050667)4.65925793
26serine family amino acid metabolic process (GO:0009069)4.63211206
27alpha-linolenic acid metabolic process (GO:0036109)4.61658765
28amino-acid betaine metabolic process (GO:0006577)4.60112904
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.57778517
30nitrogen cycle metabolic process (GO:0071941)4.57483556
31high-density lipoprotein particle remodeling (GO:0034375)4.55762300
32peptidyl-glutamic acid carboxylation (GO:0017187)4.47775061
33protein carboxylation (GO:0018214)4.47775061
34regulation of fibrinolysis (GO:0051917)4.46345231
35alpha-amino acid catabolic process (GO:1901606)4.46016809
36serine family amino acid biosynthetic process (GO:0009070)4.39247471
37regulation of triglyceride catabolic process (GO:0010896)4.35944193
38* aromatic amino acid family metabolic process (GO:0009072)4.31477933
39protein maturation by protein folding (GO:0022417)4.28761531
40regulation of protein activation cascade (GO:2000257)4.28002171
41bile acid metabolic process (GO:0008206)4.26346666
42cellular amino acid catabolic process (GO:0009063)4.23935279
43complement activation, alternative pathway (GO:0006957)4.19679799
44cellular modified amino acid catabolic process (GO:0042219)4.17464682
45cellular ketone body metabolic process (GO:0046950)4.16350113
46regulation of cholesterol esterification (GO:0010872)4.12507071
47proline biosynthetic process (GO:0006561)4.09562351
48triglyceride homeostasis (GO:0070328)4.09148630
49acylglycerol homeostasis (GO:0055090)4.09148630
50negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.08099836
51negative regulation of cholesterol transport (GO:0032375)4.05205871
52negative regulation of sterol transport (GO:0032372)4.05205871
53ethanol oxidation (GO:0006069)4.01400229
54aspartate family amino acid catabolic process (GO:0009068)4.00871332
55regulation of complement activation (GO:0030449)3.99839210
56protein retention in ER lumen (GO:0006621)3.96904163
572-oxoglutarate metabolic process (GO:0006103)3.95775315
58coenzyme catabolic process (GO:0009109)3.93500546
59tyrosine metabolic process (GO:0006570)3.93239276
60short-chain fatty acid metabolic process (GO:0046459)3.92980967
61glutamate metabolic process (GO:0006536)3.89564743
62reverse cholesterol transport (GO:0043691)3.89516908
63fatty acid beta-oxidation (GO:0006635)3.88761927
64NADH metabolic process (GO:0006734)3.88701716
65plasma lipoprotein particle remodeling (GO:0034369)3.88597949
66protein-lipid complex remodeling (GO:0034368)3.88597949
67macromolecular complex remodeling (GO:0034367)3.88597949
68maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.87213195
69acetyl-CoA metabolic process (GO:0006084)3.82444003
70plasma lipoprotein particle clearance (GO:0034381)3.82335494
71drug catabolic process (GO:0042737)3.80223924
72carboxylic acid catabolic process (GO:0046395)3.79612942
73organic acid catabolic process (GO:0016054)3.79612942
74aldehyde catabolic process (GO:0046185)3.79088903
75arginine metabolic process (GO:0006525)3.75646992
76valine metabolic process (GO:0006573)3.73144257
77imidazole-containing compound metabolic process (GO:0052803)3.72190500
78fatty acid oxidation (GO:0019395)3.71162253
79indolalkylamine metabolic process (GO:0006586)3.69365860
80cellular glucuronidation (GO:0052695)3.68649844
81daunorubicin metabolic process (GO:0044597)3.68442472
82polyketide metabolic process (GO:0030638)3.68442472
83doxorubicin metabolic process (GO:0044598)3.68442472
84benzene-containing compound metabolic process (GO:0042537)3.67429189
85drug transmembrane transport (GO:0006855)3.66241539
86negative regulation of fatty acid biosynthetic process (GO:0045717)3.64922625
87phospholipid efflux (GO:0033700)3.64662814
88nucleobase-containing small molecule interconversion (GO:0015949)3.64511705
89urate metabolic process (GO:0046415)3.64357398
90lipid oxidation (GO:0034440)3.62316289
91carnitine metabolic process (GO:0009437)3.61555355
92amine catabolic process (GO:0009310)3.61030976
93cellular biogenic amine catabolic process (GO:0042402)3.61030976
94regulation of cholesterol homeostasis (GO:2000188)3.60501240
95ketone body metabolic process (GO:1902224)3.60124699
96heme transport (GO:0015886)3.59365601
97fatty acid catabolic process (GO:0009062)3.58028241
98monocarboxylic acid catabolic process (GO:0072329)3.56221418
99bile acid and bile salt transport (GO:0015721)3.56013880
100positive regulation of triglyceride lipase activity (GO:0061365)3.54038971
101positive regulation of lipoprotein lipase activity (GO:0051006)3.54038971
102branched-chain amino acid catabolic process (GO:0009083)3.51938365
103dicarboxylic acid biosynthetic process (GO:0043650)3.48406118
104desmosome organization (GO:0002934)3.46864306
105L-serine metabolic process (GO:0006563)3.40233308
106plasma lipoprotein particle assembly (GO:0034377)3.37137906
107response to nitrosative stress (GO:0051409)3.36954769
108branched-chain amino acid metabolic process (GO:0009081)3.36235630
109glutamine family amino acid biosynthetic process (GO:0009084)3.35971988
110proline metabolic process (GO:0006560)3.34866551
111cholesterol efflux (GO:0033344)3.34525325
112exogenous drug catabolic process (GO:0042738)3.34270086
113pentose-phosphate shunt (GO:0006098)3.33614716
114cholesterol homeostasis (GO:0042632)3.33025604
115GDP-mannose metabolic process (GO:0019673)3.31399846
116retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.23145674
117aminoglycoside antibiotic metabolic process (GO:0030647)3.20757942
118glucose catabolic process (GO:0006007)3.12809415
119NADPH regeneration (GO:0006740)3.05232102
120glycosphingolipid catabolic process (GO:0046479)3.05040742
121glycoside metabolic process (GO:0016137)2.97564829
122glycolipid catabolic process (GO:0019377)2.97073105
123tricarboxylic acid cycle (GO:0006099)2.96109732
124glucose 6-phosphate metabolic process (GO:0051156)2.95649049
1254-hydroxyproline metabolic process (GO:0019471)2.89738360
126oxaloacetate metabolic process (GO:0006107)2.86751564
127peptidyl-proline hydroxylation (GO:0019511)2.84908836
128nucleotide-sugar biosynthetic process (GO:0009226)2.81272038
129protein hydroxylation (GO:0018126)2.81039590
130monosaccharide biosynthetic process (GO:0046364)2.78149362
131primary alcohol catabolic process (GO:0034310)2.76832951
132endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.76764402
133negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.74445794
134regulation of cholesterol biosynthetic process (GO:0045540)2.72695527
135regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.71411230
136barbed-end actin filament capping (GO:0051016)2.66182036
137protein localization to endosome (GO:0036010)2.65819318
138positive regulation of Cdc42 GTPase activity (GO:0043089)2.65499738
139gluconeogenesis (GO:0006094)2.65417859
140ribosome assembly (GO:0042255)2.64195018
141hexose biosynthetic process (GO:0019319)2.62305108
142nuclear envelope reassembly (GO:0031468)2.60738834
143mitotic nuclear envelope reassembly (GO:0007084)2.60738834
144very-low-density lipoprotein particle assembly (GO:0034379)2.57544492
145fibrinolysis (GO:0042730)2.57330313
146positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.56715741
147COPII vesicle coating (GO:0048208)2.55981739
148skin morphogenesis (GO:0043589)2.52358958
149regulation of translational fidelity (GO:0006450)2.51527083
150pinocytosis (GO:0006907)2.50633623
151epithelial cell-cell adhesion (GO:0090136)2.50533224
152regulation of mitochondrial translation (GO:0070129)2.50049102
153positive regulation of cellular amine metabolic process (GO:0033240)2.49833069
154oligosaccharide catabolic process (GO:0009313)2.48467780
155positive regulation of epidermal cell differentiation (GO:0045606)2.44064853
156mitochondrial fusion (GO:0008053)2.38861185
157fructose metabolic process (GO:0006000)2.38116468
158regulation of mammary gland epithelial cell proliferation (GO:0033599)2.35114086
159ceramide catabolic process (GO:0046514)2.35100046
160regulation of metalloenzyme activity (GO:0048552)2.34327285
161epoxygenase P450 pathway (GO:0019373)2.34315756
162regulation of early endosome to late endosome transport (GO:2000641)2.34091061
163NADP metabolic process (GO:0006739)2.33950282
164branching involved in mammary gland duct morphogenesis (GO:0060444)2.33443347
165formation of translation preinitiation complex (GO:0001731)2.32753408
166low-density lipoprotein particle clearance (GO:0034383)2.32659115
167positive regulation of keratinocyte differentiation (GO:0045618)2.32496839
168negative regulation of cell size (GO:0045792)2.30784399
169tricarboxylic acid metabolic process (GO:0072350)2.30152058
170pentose metabolic process (GO:0019321)2.30093551
171amyloid precursor protein catabolic process (GO:0042987)2.29183624
172activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.27784320
173regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.27308965
174folic acid metabolic process (GO:0046655)2.26833704
175regulation of cholesterol metabolic process (GO:0090181)2.25622209
176maternal placenta development (GO:0001893)2.25368565
177galactose catabolic process (GO:0019388)2.25260293
178cellular zinc ion homeostasis (GO:0006882)2.25196372

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.91017941
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.22219623
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.58668147
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.43861008
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.47705489
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.46473624
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.99259608
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.71942200
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.10823053
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.67702518
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.54221447
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.53366070
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.20200891
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.14699749
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.05908696
16MYC_18555785_ChIP-Seq_MESCs_Mouse1.98328489
17E2F7_22180533_ChIP-Seq_HELA_Human1.97505138
18STAT3_1855785_ChIP-Seq_MESCs_Mouse1.92575996
19ZNF263_19887448_ChIP-Seq_K562_Human1.71128667
20ESR1_21235772_ChIP-Seq_MCF-7_Human1.70507953
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.67144083
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.66297550
23ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.66283533
24NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.64952090
25CLOCK_20551151_ChIP-Seq_293T_Human1.61450495
26TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.59825265
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.57899848
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.56760040
29POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.56144293
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53814751
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53685083
32ESR1_15608294_ChIP-ChIP_MCF-7_Human1.53394534
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.52997718
34KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.50257078
35SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.48486271
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.40769351
37PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.40137186
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32113626
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32040525
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.30935688
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27423120
42CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26833728
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.26037226
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25785441
45TFEB_21752829_ChIP-Seq_HELA_Human1.24235610
46RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24212854
47LXR_22292898_ChIP-Seq_THP-1_Human1.21978756
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20838578
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20489492
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.16891249
51RXRA_24833708_ChIP-Seq_LIVER_Mouse1.16008397
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16001872
53SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.14165742
54SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.14165742
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.13241991
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11853927
57TBX5_21415370_ChIP-Seq_HL-1_Mouse1.11832036
58CREB1_15753290_ChIP-ChIP_HEK293T_Human1.11769663
59SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11398485
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09991514
61CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08548031
62UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08045152
63ETS1_20019798_ChIP-Seq_JURKAT_Human1.07843098
64ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.07831908
65VDR_21846776_ChIP-Seq_THP-1_Human1.07732338
66P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07410427
67CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05101215
68SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04399615
69KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.03951256
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03750481
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02737095
72SOX2_18692474_ChIP-Seq_MEFs_Mouse1.02507296
73ESR1_20079471_ChIP-ChIP_T-47D_Human1.02110516
74* HNF4A_19822575_ChIP-Seq_HepG2_Human1.02048512
75RACK7_27058665_Chip-Seq_MCF-7_Human1.01777337
76* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01555145
77TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.01357563
78TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01048177
79TP63_17297297_ChIP-ChIP_HaCaT_Human1.01001628
80NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.00439918
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99939257
82CDX2_20551321_ChIP-Seq_CACO-2_Human0.99399112
83STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99101237
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98790196
85TET1_21451524_ChIP-Seq_MESCs_Mouse0.98414108
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97092132
87ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.97048270
88RUNX1_27514584_Chip-Seq_MCF-7_Human0.96784326
89DCP1A_22483619_ChIP-Seq_HELA_Human0.96771955
90ATF3_27146783_Chip-Seq_COLON_Human0.94271406
91ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93978429
92TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92852225
93XRN2_22483619_ChIP-Seq_HELA_Human0.92053564
94SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.90016119
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89183246
96AR_21909140_ChIP-Seq_LNCAP_Human0.88998266
97RARA_24833708_ChIP-Seq_LIVER_Mouse0.88971260
98NANOG_18555785_ChIP-Seq_MESCs_Mouse0.88611114
99* SRF_21415370_ChIP-Seq_HL-1_Mouse0.87402761
100SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86457202
101* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.85938355
102ELK3_25401928_ChIP-Seq_HUVEC_Human0.83662341
103NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.83594553
104RARB_24833708_ChIP-Seq_LIVER_Mouse0.83043848
105KLF4_18555785_ChIP-Seq_MESCs_Mouse0.81958489
106GABP_19822575_ChIP-Seq_HepG2_Human0.81728981
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80792611
108NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.80739710
109* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.79870212
110DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.79165868
111TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.78670607
112PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.77198860
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.77035954
114* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.76464893
115BCL6_27268052_Chip-Seq_Bcells_Human0.76442914
116BCOR_27268052_Chip-Seq_Bcells_Human0.75631155
117FOXA2_19822575_ChIP-Seq_HepG2_Human0.75186467
118KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.73928706
119KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.73928706
120KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.73928706
121GABP_17652178_ChIP-ChIP_JURKAT_Human0.73802236
122P68_20966046_ChIP-Seq_HELA_Human0.72995742
123* CTCF_21964334_Chip-Seq_Bcells_Human0.72389003
124GATA4_25053715_ChIP-Seq_YYC3_Human0.72079484
125ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.72016030
126EST1_17652178_ChIP-ChIP_JURKAT_Human0.71661077
127GATA6_25053715_ChIP-Seq_YYC3_Human0.70593624
128* FOXP1_21924763_ChIP-Seq_HESCs_Human0.70541185
129POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.69527992
130YY1_21170310_ChIP-Seq_MESCs_Mouse0.68592445
131PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.67072593
132MYC_22102868_ChIP-Seq_BL_Human0.67049640
133SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.65854908
134TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.64527846
135KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.63983089
136* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.63834113
137RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.63769020
138NANOG_18692474_ChIP-Seq_MEFs_Mouse0.63292412

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.53603963
2MP0005360_urolithiasis7.15922477
3MP0005085_abnormal_gallbladder_physiolo5.79885715
4MP0005365_abnormal_bile_salt5.54202145
5MP0003806_abnormal_nucleotide_metabolis4.65742740
6MP0008875_abnormal_xenobiotic_pharmacok4.38230815
7MP0010234_abnormal_vibrissa_follicle4.09458227
8MP0009840_abnormal_foam_cell3.31854420
9MP0003252_abnormal_bile_duct3.30803296
10MP0010329_abnormal_lipoprotein_level3.08682721
11* MP0005332_abnormal_amino_acid2.98806094
12MP0005083_abnormal_biliary_tract2.75579094
13MP0002877_abnormal_melanocyte_morpholog2.63679365
14MP0003195_calcinosis2.58126551
15MP0001666_abnormal_nutrient_absorption2.43860985
16MP0003191_abnormal_cellular_cholesterol2.43025342
17MP0004019_abnormal_vitamin_homeostasis2.37272011
18MP0004233_abnormal_muscle_weight2.19116357
19MP0002138_abnormal_hepatobiliary_system2.12981532
20MP0000609_abnormal_liver_physiology2.01953533
21* MP0005319_abnormal_enzyme/_coenzyme1.91741414
22MP0002118_abnormal_lipid_homeostasis1.84206644
23MP0005257_abnormal_intraocular_pressure1.83878303
24MP0003705_abnormal_hypodermis_morpholog1.83142780
25MP0003186_abnormal_redox_activity1.82620352
26MP0009780_abnormal_chondrocyte_physiolo1.70074770
27MP0009643_abnormal_urine_homeostasis1.69485498
28MP0001764_abnormal_homeostasis1.65511468
29MP0006036_abnormal_mitochondrial_physio1.61009930
30MP0008260_abnormal_autophagy1.59000094
31MP0005584_abnormal_enzyme/coenzyme_acti1.54762144
32MP0004272_abnormal_basement_membrane1.53417020
33MP0008438_abnormal_cutaneous_collagen1.53113237
34MP0000678_abnormal_parathyroid_gland1.47259569
35MP0004264_abnormal_extraembryonic_tissu1.46178446
36MP0003868_abnormal_feces_composition1.38931034
37MP0000003_abnormal_adipose_tissue1.30953149
38MP0005076_abnormal_cell_differentiation1.30596600
39MP0003693_abnormal_embryo_hatching1.29945861
40MP0000598_abnormal_liver_morphology1.26472455
41MP0005670_abnormal_white_adipose1.26097728
42MP0000751_myopathy1.25685147
43MP0002060_abnormal_skin_morphology1.24715948
44MP0003011_delayed_dark_adaptation1.21841825
45MP0003950_abnormal_plasma_membrane1.21269068
46MP0001849_ear_inflammation1.19820338
47MP0003941_abnormal_skin_development1.16513783
48MP0005636_abnormal_mineral_homeostasis1.13772791
49MP0003656_abnormal_erythrocyte_physiolo1.11823493
50MP0000858_altered_metastatic_potential1.11438623
51MP0004782_abnormal_surfactant_physiolog1.10375750
52MP0005375_adipose_tissue_phenotype1.09820791
53MP0001216_abnormal_epidermal_layer1.08179755
54MP0005451_abnormal_body_composition1.07846308
55MP0000537_abnormal_urethra_morphology1.05334253
56MP0009697_abnormal_copulation1.04175271
57MP0000749_muscle_degeneration1.03856367
58MP0006035_abnormal_mitochondrial_morpho1.00772568
59MP0001727_abnormal_embryo_implantation1.00514401
60MP0000750_abnormal_muscle_regeneration0.98454746
61MP0001730_embryonic_growth_arrest0.97614416
62MP0010030_abnormal_orbit_morphology0.96763603
63MP0010368_abnormal_lymphatic_system0.95369630
64MP0001756_abnormal_urination0.95137160
65MP0005266_abnormal_metabolism0.95001417
66MP0002896_abnormal_bone_mineralization0.94604356
67MP0004130_abnormal_muscle_cell0.94450324
68MP0003123_paternal_imprinting0.94363451
69MP0000343_altered_response_to0.93288885
70MP0005666_abnormal_adipose_tissue0.92555910
71MP0001881_abnormal_mammary_gland0.92221841
72MP0002098_abnormal_vibrissa_morphology0.91862101
73MP0005409_darkened_coat_color0.91764405
74MP0000627_abnormal_mammary_gland0.89013423
75MP0002089_abnormal_postnatal_growth/wei0.88071582
76MP0002254_reproductive_system_inflammat0.87870822
77MP0003075_altered_response_to0.87629199
78MP0005376_homeostasis/metabolism_phenot0.86283111
79MP0000013_abnormal_adipose_tissue0.86200773
80MP0005330_cardiomyopathy0.85301367
81MP0000467_abnormal_esophagus_morphology0.84839462
82MP0009053_abnormal_anal_canal0.84706963
83MP0010678_abnormal_skin_adnexa0.84106321
84MP0009763_increased_sensitivity_to0.83919073
85* MP0009642_abnormal_blood_homeostasis0.82094218
86MP0008932_abnormal_embryonic_tissue0.81016282
87MP0009379_abnormal_foot_pigmentation0.80937200
88MP0000733_abnormal_muscle_development0.80769427
89MP0003111_abnormal_nucleus_morphology0.80627619
90MP0002269_muscular_atrophy0.79511466
91MP0002837_dystrophic_cardiac_calcinosis0.78344550
92MP0008469_abnormal_protein_level0.77365729
93MP0005084_abnormal_gallbladder_morpholo0.76836369
94MP0000462_abnormal_digestive_system0.76681806
95MP0005647_abnormal_sex_gland0.76126968
96MP0004858_abnormal_nervous_system0.75010755
97MP0000762_abnormal_tongue_morphology0.74855336
98MP0002078_abnormal_glucose_homeostasis0.74155806
99MP0001853_heart_inflammation0.73909936
100MP0002136_abnormal_kidney_physiology0.73505083
101MP0000759_abnormal_skeletal_muscle0.73260881
102MP0009764_decreased_sensitivity_to0.72145197
103MP0005220_abnormal_exocrine_pancreas0.71364198
104MP0010771_integument_phenotype0.70949469
105MP0004043_abnormal_pH_regulation0.70897744
106MP0000681_abnormal_thyroid_gland0.66542911
107MP0002080_prenatal_lethality0.66426824
108MP0003077_abnormal_cell_cycle0.65926489
109MP0002971_abnormal_brown_adipose0.65361040
110MP0001243_abnormal_dermal_layer0.63967479
111MP0005058_abnormal_lysosome_morphology0.61626030
112MP0003718_maternal_effect0.59676344
113MP0000604_amyloidosis0.56769104
114MP0003646_muscle_fatigue0.56760822
115MP0003638_abnormal_response/metabolism_0.56503634
116MP0005334_abnormal_fat_pad0.56238311
117MP0002796_impaired_skin_barrier0.55583641
118MP0004185_abnormal_adipocyte_glucose0.55319941
119MP0003221_abnormal_cardiomyocyte_apopto0.54474427
120MP0005408_hypopigmentation0.54427133
121MP0005395_other_phenotype0.52579317
122MP0009765_abnormal_xenobiotic_induced0.51739817
123MP0005023_abnormal_wound_healing0.51103151
124MP0008873_increased_physiological_sensi0.48336187
125MP0002332_abnormal_exercise_endurance0.45371461
126MP0000358_abnormal_cell_content/0.44751509
127MP0002970_abnormal_white_adipose0.44622129
128MP0005535_abnormal_body_temperature0.43740904
129MP0001661_extended_life_span0.43486025
130MP0001765_abnormal_ion_homeostasis0.43134991
131MP0009115_abnormal_fat_cell0.42353947
132MP0010352_gastrointestinal_tract_polyps0.42148214
133MP0005165_increased_susceptibility_to0.41301088
134MP0009672_abnormal_birth_weight0.39845540
135MP0002135_abnormal_kidney_morphology0.39200745
136MP0000639_abnormal_adrenal_gland0.38135918
137MP0002132_abnormal_respiratory_system0.37266633
138MP0003566_abnormal_cell_adhesion0.35481610
139MP0000747_muscle_weakness0.35094664
140MP0000249_abnormal_blood_vessel0.34490639
141MP0003453_abnormal_keratinocyte_physiol0.34318755
142MP0010630_abnormal_cardiac_muscle0.33856728
143MP0005501_abnormal_skin_physiology0.33328009
144MP0008872_abnormal_physiological_respon0.32967560
145* MP0003953_abnormal_hormone_level0.32684669
146MP0000230_abnormal_systemic_arterial0.32569168
147MP0008775_abnormal_heart_ventricle0.32533974
148MP0005448_abnormal_energy_balance0.31754208
149MP0001544_abnormal_cardiovascular_syste0.31650992
150MP0005385_cardiovascular_system_phenoty0.31650992
151MP0004957_abnormal_blastocyst_morpholog0.31202244
152MP0004087_abnormal_muscle_fiber0.31128523
153MP0002168_other_aberrant_phenotype0.30845736

Predicted human phenotypes

RankGene SetZ-score
1* Abnormality of aromatic amino acid family metabolism (HP:0004338)6.08798208
2Abnormality of monocarboxylic acid metabolism (HP:0010996)5.96688779
3Intrahepatic cholestasis (HP:0001406)5.84734377
4Deep venous thrombosis (HP:0002625)5.68922345
5Xanthomatosis (HP:0000991)5.38857162
6Hypobetalipoproteinemia (HP:0003563)5.31872580
7Hyperammonemia (HP:0001987)4.97824792
8Hyperglycinuria (HP:0003108)4.67448528
9Hyperglycinemia (HP:0002154)4.61809140
10Prolonged partial thromboplastin time (HP:0003645)4.58904447
11Ketosis (HP:0001946)4.40840139
12Abnormality of glutamine family amino acid metabolism (HP:0010902)4.39797228
13Abnormality of glycine metabolism (HP:0010895)4.36576951
14Abnormality of serine family amino acid metabolism (HP:0010894)4.36576951
15Hyperlipoproteinemia (HP:0010980)4.27498029
16Hypolipoproteinemia (HP:0010981)4.06885342
17Hypoglycemic coma (HP:0001325)4.03637879
18Abnormality of aspartate family amino acid metabolism (HP:0010899)3.91951007
19Complement deficiency (HP:0004431)3.87496025
20Abnormality of fatty-acid metabolism (HP:0004359)3.79572186
21Abnormality of sulfur amino acid metabolism (HP:0004339)3.78328896
22Abnormality of pyrimidine metabolism (HP:0004353)3.72504858
23Vertebral compression fractures (HP:0002953)3.66505291
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.61667229
25Hypoalphalipoproteinemia (HP:0003233)3.58348499
26Abnormality of methionine metabolism (HP:0010901)3.55603258
27Ketoacidosis (HP:0001993)3.55228641
28Epidermoid cyst (HP:0200040)3.42178924
29Abnormality of serum amino acid levels (HP:0003112)3.40909584
30Joint hemorrhage (HP:0005261)3.39099065
31Delayed CNS myelination (HP:0002188)3.36015493
32Distal lower limb muscle weakness (HP:0009053)3.34643754
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.33297278
34Dicarboxylic aciduria (HP:0003215)3.32955259
35Abnormality of dicarboxylic acid metabolism (HP:0010995)3.32955259
36Gout (HP:0001997)3.31414432
37Fat malabsorption (HP:0002630)3.29759693
38Abnormality of the common coagulation pathway (HP:0010990)3.25437786
39Lethargy (HP:0001254)3.22975293
40Abnormality of nucleobase metabolism (HP:0010932)3.21717300
41Abnormality of glycolipid metabolism (HP:0010969)3.13204023
42Abnormality of liposaccharide metabolism (HP:0010968)3.13204023
43Abnormality of glycosphingolipid metabolism (HP:0004343)3.13204023
44Abnormality of the intrinsic pathway (HP:0010989)3.03402184
45Cerebral edema (HP:0002181)3.01062690
46Abnormality of complement system (HP:0005339)3.00727791
47Abnormality of purine metabolism (HP:0004352)2.96323521
48Metabolic acidosis (HP:0001942)2.94405745
49Malnutrition (HP:0004395)2.79164907
50Hyperbilirubinemia (HP:0002904)2.79089896
51Hypercholesterolemia (HP:0003124)2.78246661
52Premature rupture of membranes (HP:0001788)2.73864395
53Achilles tendon contracture (HP:0001771)2.73476317
54Generalized aminoaciduria (HP:0002909)2.69603699
55Spastic diplegia (HP:0001264)2.66121955
56Abnormality of glycolysis (HP:0004366)2.66065364
57Hypokinesia (HP:0002375)2.60555589
58Abnormality of the distal phalanges of the toes (HP:0010182)2.58834234
59Hepatocellular carcinoma (HP:0001402)2.55320677
60Late onset (HP:0003584)2.54390986
61Vomiting (HP:0002013)2.52945208
62Proximal tubulopathy (HP:0000114)2.49620821
63Neonatal onset (HP:0003623)2.47804877
64Trismus (HP:0000211)2.43621577
65Steatorrhea (HP:0002570)2.43216854
66Short nail (HP:0001799)2.42952132
67Increased serum pyruvate (HP:0003542)2.42828688
68Osteolytic defects of the phalanges of the hand (HP:0009771)2.42484347
69Osteolytic defects of the hand bones (HP:0009699)2.42484347
70Myocardial infarction (HP:0001658)2.41050304
71Axonal loss (HP:0003447)2.40896425
72Hepatic necrosis (HP:0002605)2.40655837
73Progressive muscle weakness (HP:0003323)2.40048208
74Skin nodule (HP:0200036)2.39801030
75Nausea (HP:0002018)2.39044062
76Conjugated hyperbilirubinemia (HP:0002908)2.38367592
77J-shaped sella turcica (HP:0002680)2.38164637
78Irritability (HP:0000737)2.37879220
79Abnormal cartilage morphology (HP:0002763)2.36733848
80Hydroxyprolinuria (HP:0003080)2.34480518
81Abnormality of proline metabolism (HP:0010907)2.34480518
82Increased purine levels (HP:0004368)2.32613509
83Hyperuricemia (HP:0002149)2.32613509
84Increased connective tissue (HP:0009025)2.30628934
85Hypochromic microcytic anemia (HP:0004840)2.29628907
86Myoglobinuria (HP:0002913)2.27532059
87Hypoglycemic seizures (HP:0002173)2.22424032
88Prolonged neonatal jaundice (HP:0006579)2.21688639
89Flat acetabular roof (HP:0003180)2.21332624
90Vascular calcification (HP:0004934)2.20452502
91Nuclear cataract (HP:0100018)2.18297904
92Abnormal hemoglobin (HP:0011902)2.18180439
93Right ventricular cardiomyopathy (HP:0011663)2.17954827
94Ragged-red muscle fibers (HP:0003200)2.17553203
95Glycosuria (HP:0003076)2.17463085
96Abnormality of urine glucose concentration (HP:0011016)2.17463085
97Abnormality of the Achilles tendon (HP:0005109)2.16584736
98Reduced subcutaneous adipose tissue (HP:0003758)2.16113604
99Opisthotonus (HP:0002179)2.15405052
100Pancreatitis (HP:0001733)2.15040392
101Abnormality of the umbilical cord (HP:0010881)2.13616147
102Abdominal distention (HP:0003270)2.13339858
103Brushfield spots (HP:0001088)2.12703050
104Asymmetry of the thorax (HP:0001555)2.12520958
105Cholelithiasis (HP:0001081)2.09770137
106Mitral stenosis (HP:0001718)2.09347885
107Distal lower limb amyotrophy (HP:0008944)2.09322377
108Esophageal varix (HP:0002040)2.09282661
109Protrusio acetabuli (HP:0003179)2.08310144
110Spinal cord compression (HP:0002176)2.05892644
111Acute encephalopathy (HP:0006846)2.05471233
112Spontaneous abortion (HP:0005268)2.04949035
113Hyperacusis (HP:0010780)2.03928195
114Vacuolated lymphocytes (HP:0001922)2.03211208
115Micronodular cirrhosis (HP:0001413)2.02603393
116Alkalosis (HP:0001948)2.02407289
117Reduced antithrombin III activity (HP:0001976)2.02219632
118Mucopolysacchariduria (HP:0008155)2.01284638
119Urinary glycosaminoglycan excretion (HP:0003541)2.01284638
120Multiple enchondromatosis (HP:0005701)2.01047896
121Abnormality of iron homeostasis (HP:0011031)2.00761512
122Rhabdomyolysis (HP:0003201)2.00580834
123Abnormal gallbladder morphology (HP:0012437)1.98371167
124Glomerulonephritis (HP:0000099)1.98115156
125Hyperparathyroidism (HP:0000843)1.98079648
126Increased muscle lipid content (HP:0009058)1.97660987
127Abnormality of transition element cation homeostasis (HP:0011030)1.97624900
128Cardiovascular calcification (HP:0011915)1.97494486
129Back pain (HP:0003418)1.97398543
130Rough bone trabeculation (HP:0100670)1.96070041
131Centrally nucleated skeletal muscle fibers (HP:0003687)1.96036673
132Dysostosis multiplex (HP:0000943)1.95237023
133Systemic lupus erythematosus (HP:0002725)1.94802846
134Upper limb amyotrophy (HP:0009129)1.93609750
135Distal upper limb amyotrophy (HP:0007149)1.93609750
136Hyperinsulinemic hypoglycemia (HP:0000825)1.92819718
137Abnormality of mucopolysaccharide metabolism (HP:0011020)1.91892445
138Abnormality of polysaccharide metabolism (HP:0011012)1.91892445
139Abnormality of glycosaminoglycan metabolism (HP:0004371)1.91892445
140Generalized amyotrophy (HP:0003700)1.90628784
141Abnormality of carpal bone ossification (HP:0006257)1.89668613
142Abnormal gallbladder physiology (HP:0012438)1.87978209
143Cholecystitis (HP:0001082)1.87978209
144Sensorimotor neuropathy (HP:0007141)1.86656188
145Multiple lipomas (HP:0001012)1.86309068
146Abnormalities of placenta or umbilical cord (HP:0001194)1.86291836
147Hemorrhage of the eye (HP:0011885)1.86036376
148Testicular atrophy (HP:0000029)1.82899451
149Abnormal enzyme/coenzyme activity (HP:0012379)1.82765687
150Increased serum ferritin (HP:0003281)1.82743298
151Elbow flexion contracture (HP:0002987)1.81160024
152Lactic acidosis (HP:0003128)1.80658956
153Ulnar bowing (HP:0003031)1.80358934
154CNS demyelination (HP:0007305)1.79898781
155Menorrhagia (HP:0000132)1.78393588
156Rickets (HP:0002748)1.78383127
157Abnormal trabecular bone morphology (HP:0100671)1.77026460
158Bone pain (HP:0002653)1.76617413
159Paraparesis (HP:0002385)1.73094556
160Exercise-induced myalgia (HP:0003738)1.72659804
161Cardiomegaly (HP:0001640)1.71253455
162Fasciculations (HP:0002380)1.70942293
163Mildly elevated creatine phosphokinase (HP:0008180)1.69707126
164Cervical subluxation (HP:0003308)1.69226420
165Myopathic facies (HP:0002058)1.67102145

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.69926343
2PKN23.61423442
3IRAK33.57345954
4TRIB33.24695070
5ERN13.20682766
6NME23.14049363
7TESK12.65920501
8FLT32.60343543
9MAP3K112.58474456
10FGFR42.58453961
11SIK12.52443947
12NEK12.22019731
13PBK2.14280787
14SMG12.09517306
15KDR1.98082479
16LIMK11.69736986
17MAP3K121.68119527
18TLK11.67429899
19EPHA21.64634997
20STK38L1.63415617
21MAPK111.55309652
22VRK21.49247110
23MST1R1.48185402
24PINK11.45886644
25MAPKAPK31.42023695
26MAP2K31.40998978
27LATS21.36485153
28NEK91.34639698
29TESK21.34192989
30PIM21.21792118
31EIF2AK11.17493837
32ERBB41.17453782
33TTN1.12477806
34GRK61.11935734
35PDK41.11888911
36PDK31.11888911
37ILK1.11433155
38ABL21.07533721
39MST41.04995182
40MAP3K101.04144987
41WEE11.03458372
42LMTK21.03371801
43MAP2K61.02455337
44TIE11.00719115
45MAP3K30.98668058
46DYRK1B0.97678341
47MAP2K20.95338889
48PTK60.94960414
49PRPF4B0.91280141
50PIK3CG0.88686727
51ICK0.88379710
52TYK20.87812551
53WNK40.86486850
54NME10.86460720
55RPS6KB20.85114864
56PRKCI0.84542666
57CDK80.81185881
58BUB10.78246591
59DAPK30.78243173
60RPS6KA40.75574426
61TBK10.75126871
62MAPK150.74615077
63TAOK20.73918594
64SCYL20.73496848
65BRSK10.72488747
66PAK40.71669648
67MATK0.70810770
68PRKAA20.70215901
69MAP2K40.69749972
70PDPK10.68562839
71LRRK20.68074262
72MUSK0.67641287
73DAPK10.67574560
74CDK70.67367723
75TGFBR10.67175197
76MAP3K20.67015129
77CDK40.66968204
78TGFBR20.66474951
79PDK20.65981980
80MAP3K80.65728152
81TAOK30.65263796
82STK160.65141860
83ARAF0.64775717
84PTK20.64308971
85PDGFRA0.62085532
86DDR20.62056429
87MAP3K70.61906639
88CDK60.61549927
89BMX0.59657475
90PRKG20.59639032
91JAK20.58636198
92LATS10.58153479
93MET0.57809311
94MYLK0.57592602
95CDK120.56752338
96GSK3A0.55407733
97TSSK60.54017738
98AURKA0.52431957
99MTOR0.52088944
100TTK0.51759745
101MAP3K10.51412362
102MAPK40.51151454
103DYRK30.49831460
104PRKAA10.49450086
105MAP2K10.48791571
106ERBB20.47779615
107EIF2AK30.47330823
108MAP3K50.46662944
109PHKG10.45695502
110PHKG20.45695502
111INSRR0.45644374
112AURKB0.44845904
113RIPK10.44631812
114PIM10.44597856
115BRAF0.44336566
116* CAMK2G0.43826546
117FER0.43130688
118KSR20.42064770
119EPHB10.41922952
120CSK0.41793902
121EPHB20.41123073
122CAMK2D0.40781264
123MAP3K60.40320049
124EEF2K0.40214432
125ACVR1B0.40165852
126STK100.39741446
127ZAP700.38645640
128PRKD30.38072187
129PRKACG0.38037398
130IRAK20.37688898
131PAK10.37512770
132NEK20.37432827
133MAPKAPK20.36826047
134MAP3K90.36514805
135AKT20.36220483
136TRPM70.35987165
137STK380.32939010
138NEK60.32886014
139CDK90.31996567
140NTRK10.31203530
141SRPK10.30981525
142PRKD20.27978767

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.71986445
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.28634029
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.21160344
4Nitrogen metabolism_Homo sapiens_hsa009103.03136517
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.96851286
6Arginine biosynthesis_Homo sapiens_hsa002202.90493331
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.66026305
8Fatty acid degradation_Homo sapiens_hsa000712.62998859
9Tryptophan metabolism_Homo sapiens_hsa003802.55799584
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.52382565
11Other glycan degradation_Homo sapiens_hsa005112.47867158
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.45686227
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.36085485
14Propanoate metabolism_Homo sapiens_hsa006402.27022002
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.16342714
16Butanoate metabolism_Homo sapiens_hsa006502.09193335
17Complement and coagulation cascades_Homo sapiens_hsa046102.06881756
18Peroxisome_Homo sapiens_hsa041462.06234415
19Fatty acid metabolism_Homo sapiens_hsa012121.85446991
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.77489675
21PPAR signaling pathway_Homo sapiens_hsa033201.73936227
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.73374933
23Selenocompound metabolism_Homo sapiens_hsa004501.72450295
24Sulfur relay system_Homo sapiens_hsa041221.70436961
25Carbon metabolism_Homo sapiens_hsa012001.69148310
26beta-Alanine metabolism_Homo sapiens_hsa004101.69145223
27Biosynthesis of amino acids_Homo sapiens_hsa012301.69110470
28Pyruvate metabolism_Homo sapiens_hsa006201.68306450
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.67430231
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.66665898
31Chemical carcinogenesis_Homo sapiens_hsa052041.65693657
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.64518360
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.64351305
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.59145964
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.58667531
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57096211
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.56720782
38Histidine metabolism_Homo sapiens_hsa003401.53413736
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44245371
40Phenylalanine metabolism_Homo sapiens_hsa003601.39112959
41Retinol metabolism_Homo sapiens_hsa008301.37629815
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.36742854
43Vibrio cholerae infection_Homo sapiens_hsa051101.34626666
44* Folate biosynthesis_Homo sapiens_hsa007901.33223112
45Caffeine metabolism_Homo sapiens_hsa002321.31011722
46Arginine and proline metabolism_Homo sapiens_hsa003301.29310371
47Bile secretion_Homo sapiens_hsa049761.27896554
48Starch and sucrose metabolism_Homo sapiens_hsa005001.26921127
49One carbon pool by folate_Homo sapiens_hsa006701.24831697
50N-Glycan biosynthesis_Homo sapiens_hsa005101.22698234
51Lysosome_Homo sapiens_hsa041421.22019636
52Tyrosine metabolism_Homo sapiens_hsa003501.20644692
53Fat digestion and absorption_Homo sapiens_hsa049751.16354490
54Sulfur metabolism_Homo sapiens_hsa009201.15628666
55Fatty acid elongation_Homo sapiens_hsa000621.11795017
56Staphylococcus aureus infection_Homo sapiens_hsa051501.10963800
57Glutathione metabolism_Homo sapiens_hsa004801.04563806
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03986338
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99404173
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95910771
61Pentose phosphate pathway_Homo sapiens_hsa000300.93137229
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88543909
63Vitamin digestion and absorption_Homo sapiens_hsa049770.86118785
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.83087215
65Vitamin B6 metabolism_Homo sapiens_hsa007500.80196030
66ABC transporters_Homo sapiens_hsa020100.79750135
67Lysine degradation_Homo sapiens_hsa003100.79510955
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78430334
69Fructose and mannose metabolism_Homo sapiens_hsa000510.76654458
70Sphingolipid metabolism_Homo sapiens_hsa006000.76339121
71Base excision repair_Homo sapiens_hsa034100.67958851
72Steroid biosynthesis_Homo sapiens_hsa001000.66174074
73Glycerolipid metabolism_Homo sapiens_hsa005610.64009840
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61574035
75Mineral absorption_Homo sapiens_hsa049780.60403520
76Galactose metabolism_Homo sapiens_hsa000520.59717647
77* Metabolic pathways_Homo sapiens_hsa011000.59458794
78Ribosome_Homo sapiens_hsa030100.50161113
79Nucleotide excision repair_Homo sapiens_hsa034200.49136996
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42438603
81Fatty acid biosynthesis_Homo sapiens_hsa000610.42000054
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39794223
83Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.38848762
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36095512
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34407642
86Proteoglycans in cancer_Homo sapiens_hsa052050.33226864
87Parkinsons disease_Homo sapiens_hsa050120.31793802
88Shigellosis_Homo sapiens_hsa051310.30922153
89Chronic myeloid leukemia_Homo sapiens_hsa052200.29788817
90Oxidative phosphorylation_Homo sapiens_hsa001900.28683870
91Small cell lung cancer_Homo sapiens_hsa052220.27275991
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26037305
93Hepatitis C_Homo sapiens_hsa051600.25739367
94Tight junction_Homo sapiens_hsa045300.23792788
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.23699656
96Proteasome_Homo sapiens_hsa030500.23480120
97Pyrimidine metabolism_Homo sapiens_hsa002400.22272714
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.21064167
99Insulin resistance_Homo sapiens_hsa049310.18952794
100Prion diseases_Homo sapiens_hsa050200.15461457
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12073726
102AMPK signaling pathway_Homo sapiens_hsa041520.11666131
103Bladder cancer_Homo sapiens_hsa052190.07618226
104Linoleic acid metabolism_Homo sapiens_hsa005910.06854409
105Glucagon signaling pathway_Homo sapiens_hsa049220.06609490
106Huntingtons disease_Homo sapiens_hsa050160.05498119
107DNA replication_Homo sapiens_hsa030300.05042733
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.05035544
109Alzheimers disease_Homo sapiens_hsa050100.01724748
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.01468373
111Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0864609
112Renin-angiotensin system_Homo sapiens_hsa04614-0.0683314
113Thyroid cancer_Homo sapiens_hsa05216-0.0522423
114Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008-0.0497128
115Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0453997
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0433987
117Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0407598
118Mismatch repair_Homo sapiens_hsa03430-0.0242381
119Insulin signaling pathway_Homo sapiens_hsa04910-0.0145450

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