SPRED2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.20219906
2locomotory exploration behavior (GO:0035641)4.76937032
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.70166880
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.42666551
5glutamate secretion (GO:0014047)4.36567345
6vocalization behavior (GO:0071625)4.21491003
7layer formation in cerebral cortex (GO:0021819)4.17293411
8positive regulation of cell size (GO:0045793)4.13386908
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.06333712
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.04575446
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.93693722
12cellular protein complex localization (GO:0034629)3.90738065
13sodium ion export (GO:0071436)3.84854400
14synaptic vesicle exocytosis (GO:0016079)3.82602310
15regulation of cholesterol biosynthetic process (GO:0045540)3.68523769
16regulation of glutamate receptor signaling pathway (GO:1900449)3.66122549
17positive regulation of synapse maturation (GO:0090129)3.62020999
18regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.61478553
19maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.56370096
20dendritic spine morphogenesis (GO:0060997)3.56307539
21dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.55045850
22regulation of long-term neuronal synaptic plasticity (GO:0048169)3.53353048
23exploration behavior (GO:0035640)3.52987560
24basement membrane organization (GO:0071711)3.52574524
25cellular potassium ion homeostasis (GO:0030007)3.51277350
26skin morphogenesis (GO:0043589)3.50194949
27cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.45338804
28COPI coating of Golgi vesicle (GO:0048205)3.45001790
29Golgi transport vesicle coating (GO:0048200)3.45001790
30regulation of synaptic vesicle exocytosis (GO:2000300)3.41973170
31ionotropic glutamate receptor signaling pathway (GO:0035235)3.41594783
32neuronal action potential propagation (GO:0019227)3.40742423
33diaphragm development (GO:0060539)3.40593201
34regulation of neuronal synaptic plasticity (GO:0048168)3.39699242
35regulation of cholesterol homeostasis (GO:2000188)3.33879744
36hypotonic response (GO:0006971)3.30742392
37cell migration in hindbrain (GO:0021535)3.29996213
38protein retention in ER lumen (GO:0006621)3.27734628
39cell communication by electrical coupling (GO:0010644)3.27702937
40positive regulation of extracellular matrix organization (GO:1903055)3.25798205
41proline transport (GO:0015824)3.25396224
42planar cell polarity pathway involved in neural tube closure (GO:0090179)3.25278058
43protein localization to synapse (GO:0035418)3.23748983
44regulation of synapse structural plasticity (GO:0051823)3.18010976
45neurotransmitter secretion (GO:0007269)3.15117416
46cytoskeletal anchoring at plasma membrane (GO:0007016)3.13892228
47glutamate receptor signaling pathway (GO:0007215)3.12437992
48skeletal muscle organ development (GO:0060538)3.10044728
49cell adhesion mediated by integrin (GO:0033627)3.09806152
50synaptic vesicle endocytosis (GO:0048488)3.09573765
51neuromuscular process controlling balance (GO:0050885)3.07924694
52response to lipoprotein particle (GO:0055094)3.07874765
53activation of protein kinase A activity (GO:0034199)3.07462589
54establishment of nucleus localization (GO:0040023)3.06283870
55innervation (GO:0060384)3.03509439
56protein localization to endosome (GO:0036010)3.03430379
57regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.03293994
58cerebellar Purkinje cell differentiation (GO:0021702)3.02947471
59G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.02658459
60synaptic transmission, glutamatergic (GO:0035249)3.00752377
61positive regulation of fibroblast migration (GO:0010763)2.99644313
62regulation of clathrin-mediated endocytosis (GO:2000369)2.93344708
63long-term memory (GO:0007616)2.92930333
64regulation of synaptic vesicle transport (GO:1902803)2.92257427
65dendritic spine organization (GO:0097061)2.90644695
66regulation of synaptic plasticity (GO:0048167)2.89483845
67axonal fasciculation (GO:0007413)2.87192048
68chondrocyte proliferation (GO:0035988)2.86466358
69regulation of dendritic spine morphogenesis (GO:0061001)2.85789733
70pre-miRNA processing (GO:0031054)2.84243400
71protein hydroxylation (GO:0018126)2.81730651
72protein carboxylation (GO:0018214)2.81714190
73peptidyl-glutamic acid carboxylation (GO:0017187)2.81714190
74membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.81109930
75activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.80742820
76dendrite morphogenesis (GO:0048813)2.80183105
77regulation of excitatory postsynaptic membrane potential (GO:0060079)2.79713393
78negative regulation of vascular permeability (GO:0043116)2.78708045
79very-low-density lipoprotein particle assembly (GO:0034379)2.78525702
80positive regulation of DNA-dependent DNA replication (GO:2000105)2.78136555
81hemidesmosome assembly (GO:0031581)2.77444788
82cerebellar granule cell differentiation (GO:0021707)2.77136303
83negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.76998791
84neuron-neuron synaptic transmission (GO:0007270)2.74186399
85cellular response to prostaglandin stimulus (GO:0071379)2.73351419
86negative regulation of fibrinolysis (GO:0051918)2.72672000
87cell-substrate junction assembly (GO:0007044)2.72570998
88positive regulation of nuclease activity (GO:0032075)2.72480213
89focal adhesion assembly (GO:0048041)2.71986008
90cell-substrate adherens junction assembly (GO:0007045)2.71986008
91neuron recognition (GO:0008038)2.71540765
92suckling behavior (GO:0001967)2.70327291
93neuron cell-cell adhesion (GO:0007158)2.69214053
94regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.69090081
95intestinal cholesterol absorption (GO:0030299)2.67462683
96embryonic retina morphogenesis in camera-type eye (GO:0060059)2.67201927
97regulation of postsynaptic membrane potential (GO:0060078)2.67009058
98regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.66064472
99ER-nucleus signaling pathway (GO:0006984)2.65961820
100desmosome organization (GO:0002934)2.64707363
101protein heterotrimerization (GO:0070208)2.64416296
102negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.64211921
103positive regulation of dendritic spine morphogenesis (GO:0061003)2.63900390
104branching involved in mammary gland duct morphogenesis (GO:0060444)2.62990269
105positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.61859504
106regulation of stem cell maintenance (GO:2000036)2.60036564
107behavioral fear response (GO:0001662)2.59954606
108behavioral defense response (GO:0002209)2.59954606
109craniofacial suture morphogenesis (GO:0097094)2.59931098
110long-term synaptic potentiation (GO:0060291)2.58773069
111semaphorin-plexin signaling pathway (GO:0071526)2.57406486
112protein complex localization (GO:0031503)2.57295381
113endothelial cell morphogenesis (GO:0001886)2.56936896
114neurotransmitter-gated ion channel clustering (GO:0072578)2.56122870
115negative regulation of potassium ion transmembrane transport (GO:1901380)2.55754721
116negative regulation of hormone biosynthetic process (GO:0032353)2.55217227
117negative regulation of hormone metabolic process (GO:0032351)2.55217227
118epithelial cell-cell adhesion (GO:0090136)2.55160499
119cell communication involved in cardiac conduction (GO:0086065)2.54355078
120regulation of mammary gland epithelial cell proliferation (GO:0033599)2.53757824
121peptidyl-proline hydroxylation (GO:0019511)2.52441598
122endoplasmic reticulum unfolded protein response (GO:0030968)2.51815718
123negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.50553138
124glucocorticoid receptor signaling pathway (GO:0042921)2.50293249
125regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.49917018
126COPII vesicle coating (GO:0048208)2.49317930
127gamma-aminobutyric acid transport (GO:0015812)2.47979735
128membrane repolarization (GO:0086009)2.47753524
129regulation of synapse maturation (GO:0090128)2.47088135
130neuromuscular process (GO:0050905)2.45408401
131membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.44235300
132fear response (GO:0042596)2.43495731
133adherens junction assembly (GO:0034333)2.42512703
134positive regulation of osteoblast proliferation (GO:0033690)2.39524383
135regulation of ARF protein signal transduction (GO:0032012)2.39514008
136positive regulation of membrane potential (GO:0045838)2.39296559
137peptidyl-arginine methylation (GO:0018216)2.38638948
138peptidyl-arginine N-methylation (GO:0035246)2.38638948
139signal complex assembly (GO:0007172)2.38558331
140plasma membrane repair (GO:0001778)2.37713423
141long term synaptic depression (GO:0060292)2.37552808
142proline biosynthetic process (GO:0006561)2.36720802
143camera-type eye morphogenesis (GO:0048593)2.36584233
144membrane depolarization during action potential (GO:0086010)2.36228053
145Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.36207533
146negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.35971253
147regulation of plasminogen activation (GO:0010755)2.35944978
148regulation of nuclease activity (GO:0032069)2.35886741
149retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.34746969
150positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.34676875
151auditory behavior (GO:0031223)2.34536909
152cellular sodium ion homeostasis (GO:0006883)2.34367245
153protein-lipid complex assembly (GO:0065005)2.34034790
154cellular response to unfolded protein (GO:0034620)2.33642444
155mRNA stabilization (GO:0048255)2.33381340
156RNA stabilization (GO:0043489)2.33381340
157neurotransmitter transport (GO:0006836)2.33273409
158activation of MAPKKK activity (GO:0000185)2.33172896
159positive regulation of adherens junction organization (GO:1903393)2.32963420
160adenine nucleotide transport (GO:0051503)2.32747702
161plasma lipoprotein particle assembly (GO:0034377)2.32567471
162purine nucleotide transport (GO:0015865)2.32553030
163establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.32456933
164central nervous system projection neuron axonogenesis (GO:0021952)2.32020306
165G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.31144233
166gamma-aminobutyric acid signaling pathway (GO:0007214)2.31059867
167G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.29565159
168potassium ion import (GO:0010107)2.29066689
169low-density lipoprotein particle clearance (GO:0034383)2.28810087
170muscle cell migration (GO:0014812)2.28368451
171axon extension (GO:0048675)2.28255256
172apical protein localization (GO:0045176)2.27990286
173regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.27780000
174cochlea development (GO:0090102)2.27765827
175regulation of neurotransmitter secretion (GO:0046928)2.27660267
176clathrin coat assembly (GO:0048268)2.27589042
177regulation of extracellular matrix organization (GO:1903053)2.27052929
178lung epithelium development (GO:0060428)2.26949092
179regulation of establishment of planar polarity (GO:0090175)2.26698560
180regulation of early endosome to late endosome transport (GO:2000641)2.26351546
181retina vasculature morphogenesis in camera-type eye (GO:0061299)2.25023806
182negative regulation of chondrocyte differentiation (GO:0032331)2.24638747
183mesodermal cell differentiation (GO:0048333)2.23933620
184regulation of NFAT protein import into nucleus (GO:0051532)2.23584068
185endothelial cell chemotaxis (GO:0035767)2.23359358
186hippo signaling (GO:0035329)2.21954175
187substrate adhesion-dependent cell spreading (GO:0034446)2.21518610
188lung vasculature development (GO:0060426)2.20284874
189activation of Rac GTPase activity (GO:0032863)2.17374243
190insulin-like growth factor receptor signaling pathway (GO:0048009)2.16057976
191intestinal absorption (GO:0050892)2.14876096
192regulation of fibrinolysis (GO:0051917)2.14752161
193positive regulation of focal adhesion assembly (GO:0051894)2.14491431
194positive regulation of cell junction assembly (GO:1901890)2.14491431
195cellular copper ion homeostasis (GO:0006878)2.14210013
196regulation of cholesterol metabolic process (GO:0090181)2.12991149

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.47044952
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.05490352
3RARG_19884340_ChIP-ChIP_MEFs_Mouse2.77485071
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.73400848
5* RARB_27405468_Chip-Seq_BRAIN_Mouse2.51644452
6* CLOCK_20551151_ChIP-Seq_293T_Human2.50295213
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.49947256
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.42133600
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.39361028
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.37287574
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.37287574
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.36612748
13* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.35421894
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.34614099
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.30909273
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.30549689
17AR_21909140_ChIP-Seq_LNCAP_Human2.26081600
18* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.26041607
19* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.24241122
20HIF1A_21447827_ChIP-Seq_MCF-7_Human2.22893846
21* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.21456070
22DROSHA_22980978_ChIP-Seq_HELA_Human2.21091219
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.13905458
24* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.09022223
25JARID2_20075857_ChIP-Seq_MESCs_Mouse2.07306701
26ESR1_21235772_ChIP-Seq_MCF-7_Human2.06757309
27E2F7_22180533_ChIP-Seq_HELA_Human2.00969691
28TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.98914321
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.98668873
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.96700993
31* KDM2B_26808549_Chip-Seq_K562_Human1.96156308
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.95570803
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.93595156
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.93219985
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.92930440
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.91617821
37* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.90721673
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.88456512
39RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.88353374
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.87938529
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.87502324
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.87154938
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.87103733
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85118943
45REST_21632747_ChIP-Seq_MESCs_Mouse1.83858801
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.83795395
47GBX2_23144817_ChIP-Seq_PC3_Human1.82163546
48NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.80866056
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76863523
50ELK3_25401928_ChIP-Seq_HUVEC_Human1.75970442
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75424277
52SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.72878415
53* ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.72035843
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.68562123
55ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.68537497
56DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.62617011
57RACK7_27058665_Chip-Seq_MCF-7_Human1.61337564
58SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.60125336
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59065541
60* FOXA2_19822575_ChIP-Seq_HepG2_Human1.57497081
61* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.56306418
62ZNF263_19887448_ChIP-Seq_K562_Human1.55464752
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.53643732
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.53262658
65REST_18959480_ChIP-ChIP_MESCs_Mouse1.53051226
66SOX9_24532713_ChIP-Seq_HFSC_Mouse1.52485760
67* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.52292461
68EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.50584361
69* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.49779991
70SUZ12_27294783_Chip-Seq_ESCs_Mouse1.49565451
71TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49508556
72MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.49213457
73* RING1B_27294783_Chip-Seq_NPCs_Mouse1.48887601
74* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48630761
75AR_21572438_ChIP-Seq_LNCaP_Human1.48583777
76* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.46092653
77* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.45500879
78* KDM2B_26808549_Chip-Seq_DND41_Human1.44469635
79WT1_19549856_ChIP-ChIP_CCG9911_Human1.42119676
80CDX2_20551321_ChIP-Seq_CACO-2_Human1.41572475
81* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.40245263
82TP53_16413492_ChIP-PET_HCT116_Human1.39932868
83PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.39113793
84PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.38705060
85SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.38090800
86KDM2B_26808549_Chip-Seq_JURKAT_Human1.37485192
87SMAD_19615063_ChIP-ChIP_OVARY_Human1.36150671
88FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.34714544
89ATF3_27146783_Chip-Seq_COLON_Human1.34369413
90* RXR_22158963_ChIP-Seq_LIVER_Mouse1.33801304
91RING1B_27294783_Chip-Seq_ESCs_Mouse1.33746376
92* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.33708938
93TP53_22127205_ChIP-Seq_IMR90_Human1.32948354
94* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32040639
95CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.31640794
96RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.30809082
97* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.30700192
98KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30312113
99AHR_22903824_ChIP-Seq_MCF-7_Human1.28243694
100UBF1/2_26484160_Chip-Seq_HMECs_Human1.27373123
101DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26486582
102UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25982471
103TBX20_22080862_ChIP-Seq_HEART_Mouse1.24933090
104TBX20_22328084_ChIP-Seq_HEART_Mouse1.24933090
105* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.24290375
106* ISL1_27105846_Chip-Seq_CPCs_Mouse1.20285196
107NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19269311
108* AR_19668381_ChIP-Seq_PC3_Human1.18885546
109* RUNX1_27514584_Chip-Seq_MCF-7_Human1.18685696
110* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.18579406
111SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18423553
112TP53_20018659_ChIP-ChIP_R1E_Mouse1.18365673
113RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17781768
114* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17605167
115EP300_21415370_ChIP-Seq_HL-1_Mouse1.17271490
116RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16533048
117* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13888319
118* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13888319
119ARNT_22903824_ChIP-Seq_MCF-7_Human1.13337703
120* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13287187
121NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13199595
122KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11800663
123* FOXO3_23340844_ChIP-Seq_DLD1_Human1.11607290
124SMAD3_21741376_ChIP-Seq_HESCs_Human1.11496801
125KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11476920
126LXR_22158963_ChIP-Seq_LIVER_Mouse1.11216300
127* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11174623
128DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10383919
129PPAR_26484153_Chip-Seq_NCI-H1993_Human1.09419700
130PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08146936
131* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.07783009
132SMAD4_21799915_ChIP-Seq_A2780_Human1.06154362
133P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06096246
134SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.05426300
135CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05110967
136SOX2_21211035_ChIP-Seq_LN229_Gbm1.04871204
137TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.04221632
138TP63_17297297_ChIP-ChIP_HaCaT_Human1.03981227
139* TCF7_22412390_ChIP-Seq_EML_Mouse1.03059428
140* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.02498669
141NANOG_21062744_ChIP-ChIP_HESCs_Human1.02379889
142ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02156911
143* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01725851
144TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01339811
145TET1_21490601_ChIP-Seq_MESCs_Mouse1.01273443
146GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.00895124
147TP53_23651856_ChIP-Seq_MEFs_Mouse1.00216056
148TBX3_20139965_ChIP-Seq_MESCs_Mouse1.00024948
149MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.97168305
150* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96998177
151ESR2_21235772_ChIP-Seq_MCF-7_Human0.96652744
152* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95652437
153KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.95113047
154KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.95113047
155KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.95113047
156SMAD4_21741376_ChIP-Seq_HESCs_Human0.93656600
157CREB1_26743006_Chip-Seq_LNCaP_Human0.93631854
158TCF4_18268006_ChIP-ChIP_LS174T_Human0.92734446
159POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92507832
160RXR_22108803_ChIP-Seq_LS180_Human0.91954422
161LXR_22292898_ChIP-Seq_THP-1_Human0.91877963
162MYC_22102868_ChIP-Seq_BL_Human0.91843081
163TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91711278
164* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.91312086
165* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.91210174
166* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.90311142
167ESR1_20079471_ChIP-ChIP_T-47D_Human0.89392269

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.26963440
2MP0000566_synostosis4.91403989
3MP0008438_abnormal_cutaneous_collagen3.60134253
4MP0003635_abnormal_synaptic_transmissio3.42558513
5MP0004270_analgesia2.94437059
6MP0002063_abnormal_learning/memory/cond2.72828225
7MP0005257_abnormal_intraocular_pressure2.71628756
8MP0003880_abnormal_central_pattern2.61496406
9MP0005409_darkened_coat_color2.47924416
10MP0004858_abnormal_nervous_system2.42447287
11MP0009745_abnormal_behavioral_response2.37659675
12MP0002064_seizures2.24755324
13MP0009046_muscle_twitch2.11192025
14MP0001968_abnormal_touch/_nociception2.10501885
15MP0002572_abnormal_emotion/affect_behav2.10301064
16MP0005623_abnormal_meninges_morphology2.08643628
17MP0009780_abnormal_chondrocyte_physiolo1.88149133
18MP0008961_abnormal_basal_metabolism1.88027606
19MP0002734_abnormal_mechanical_nocicepti1.79143487
20MP0005076_abnormal_cell_differentiation1.78084777
21MP0003283_abnormal_digestive_organ1.75660830
22MP0002735_abnormal_chemical_nociception1.68026599
23MP0008569_lethality_at_weaning1.66923715
24MP0000778_abnormal_nervous_system1.66290480
25MP0001486_abnormal_startle_reflex1.65633126
26MP0002736_abnormal_nociception_after1.64292028
27MP0004811_abnormal_neuron_physiology1.60201372
28MP0002272_abnormal_nervous_system1.58488772
29MP0002896_abnormal_bone_mineralization1.57380936
30MP0001501_abnormal_sleep_pattern1.56263668
31MP0004233_abnormal_muscle_weight1.56081252
32MP0000767_abnormal_smooth_muscle1.55975224
33MP0000467_abnormal_esophagus_morphology1.53732134
34MP0002733_abnormal_thermal_nociception1.50819390
35MP0010234_abnormal_vibrissa_follicle1.49819810
36MP0002184_abnormal_innervation1.49781864
37MP0003705_abnormal_hypodermis_morpholog1.46980643
38MP0003122_maternal_imprinting1.45607729
39MP0000733_abnormal_muscle_development1.45101094
40MP0001440_abnormal_grooming_behavior1.43925047
41MP0006138_congestive_heart_failure1.41730777
42MP0004043_abnormal_pH_regulation1.41148957
43MP0001879_abnormal_lymphatic_vessel1.39830678
44MP0002234_abnormal_pharynx_morphology1.39378837
45MP0004885_abnormal_endolymph1.38858225
46MP0001970_abnormal_pain_threshold1.37989497
47MP0000534_abnormal_ureter_morphology1.36433827
48MP0000762_abnormal_tongue_morphology1.35335273
49MP0002877_abnormal_melanocyte_morpholog1.34790881
50MP0003123_paternal_imprinting1.34742411
51MP0001915_intracranial_hemorrhage1.33270716
52MP0000955_abnormal_spinal_cord1.32772961
53MP0002557_abnormal_social/conspecific_i1.32627247
54MP0002233_abnormal_nose_morphology1.31697938
55MP0004484_altered_response_of1.30508105
56MP0002822_catalepsy1.29560289
57MP0005058_abnormal_lysosome_morphology1.28630473
58MP0002909_abnormal_adrenal_gland1.28070395
59MP0002067_abnormal_sensory_capabilities1.26686564
60MP0005275_abnormal_skin_tensile1.26614027
61MP0002653_abnormal_ependyma_morphology1.25431976
62MP0005503_abnormal_tendon_morphology1.25068161
63MP0003787_abnormal_imprinting1.24329826
64MP0000537_abnormal_urethra_morphology1.21442630
65MP0001849_ear_inflammation1.20482862
66MP0002152_abnormal_brain_morphology1.19829152
67MP0010352_gastrointestinal_tract_polyps1.18915575
68MP0003119_abnormal_digestive_system1.15920005
69MP0005508_abnormal_skeleton_morphology1.15894569
70MP0000432_abnormal_head_morphology1.15536013
71MP0003861_abnormal_nervous_system1.15004686
72MP0005197_abnormal_uvea_morphology1.14702486
73MP0009384_cardiac_valve_regurgitation1.14168550
74MP0005023_abnormal_wound_healing1.13126324
75MP0005423_abnormal_somatic_nervous1.12035824
76MP0002060_abnormal_skin_morphology1.11854805
77MP0000428_abnormal_craniofacial_morphol1.08929140
78MP0005670_abnormal_white_adipose1.08353811
79MP0009250_abnormal_appendicular_skeleto1.08314450
80MP0002116_abnormal_craniofacial_bone1.08062164
81MP0002882_abnormal_neuron_morphology1.07801551
82MP0005394_taste/olfaction_phenotype1.07581595
83MP0005499_abnormal_olfactory_system1.07581595
84MP0005167_abnormal_blood-brain_barrier1.05306124
85MP0003937_abnormal_limbs/digits/tail_de1.04544848
86MP0000751_myopathy1.03853491
87MP0005187_abnormal_penis_morphology1.03673805
88MP0000678_abnormal_parathyroid_gland1.02659714
89MP0000569_abnormal_digit_pigmentation1.01240649
90MP0000516_abnormal_urinary_system0.97876961
91MP0005367_renal/urinary_system_phenotyp0.97876961
92MP0002139_abnormal_hepatobiliary_system0.97374176
93MP0004924_abnormal_behavior0.96178529
94MP0005386_behavior/neurological_phenoty0.96178529
95MP0002249_abnormal_larynx_morphology0.95879138
96MP0002066_abnormal_motor_capabilities/c0.95873142
97MP0009672_abnormal_birth_weight0.95819739
98MP0003279_aneurysm0.94155817
99MP0003646_muscle_fatigue0.93337320
100MP0003890_abnormal_embryonic-extraembry0.92890813
101MP0003121_genomic_imprinting0.92736583
102MP0003633_abnormal_nervous_system0.91888868
103MP0003453_abnormal_keratinocyte_physiol0.91793455
104* MP0000163_abnormal_cartilage_morphology0.91524161
105MP0003329_amyloid_beta_deposits0.90611980
106MP0002084_abnormal_developmental_patter0.90111272
107MP0002089_abnormal_postnatal_growth/wei0.89811053
108MP0002932_abnormal_joint_morphology0.88897435
109MP0002086_abnormal_extraembryonic_tissu0.88301781
110MP0010030_abnormal_orbit_morphology0.88296501
111MP0004185_abnormal_adipocyte_glucose0.88057717
112MP0003942_abnormal_urinary_system0.87604482
113MP0000049_abnormal_middle_ear0.87134876
114MP0003950_abnormal_plasma_membrane0.86786048
115MP0004264_abnormal_extraembryonic_tissu0.86097028
116MP0004085_abnormal_heartbeat0.83875337
117MP0003879_abnormal_hair_cell0.82720221
118MP0008770_decreased_survivor_rate0.82210544
119MP0004215_abnormal_myocardial_fiber0.82171067
120MP0010307_abnormal_tumor_latency0.82061434
121MP0009053_abnormal_anal_canal0.81942004
122MP0005360_urolithiasis0.81457836
123MP0001664_abnormal_digestion0.81295669
124MP0003631_nervous_system_phenotype0.81130137
125MP0003091_abnormal_cell_migration0.80837093
126MP0000003_abnormal_adipose_tissue0.79924192
127MP0004145_abnormal_muscle_electrophysio0.79424307
128MP0003115_abnormal_respiratory_system0.78362753
129* MP0002113_abnormal_skeleton_development0.77523230
130MP0002925_abnormal_cardiovascular_devel0.76260636
131MP0003984_embryonic_growth_retardation0.75990726
132MP0010630_abnormal_cardiac_muscle0.75954283
133MP0000858_altered_metastatic_potential0.75502526
134MP0001672_abnormal_embryogenesis/_devel0.75417409
135MP0005380_embryogenesis_phenotype0.75417409
136MP0001614_abnormal_blood_vessel0.75401252
137MP0003935_abnormal_craniofacial_develop0.74963570
138MP0001958_emphysema0.74877491
139MP0004084_abnormal_cardiac_muscle0.74851975
140MP0001666_abnormal_nutrient_absorption0.74752685
141MP0002081_perinatal_lethality0.74191411
142MP0005451_abnormal_body_composition0.73578634
143MP0003755_abnormal_palate_morphology0.73537825
144MP0001299_abnormal_eye_distance/0.73349417
145MP0010329_abnormal_lipoprotein_level0.72694084
146MP0006054_spinal_hemorrhage0.72536360
147* MP0002109_abnormal_limb_morphology0.72531971
148MP0004272_abnormal_basement_membrane0.70265683
149MP0003045_fibrosis0.69894962
150MP0002088_abnormal_embryonic_growth/wei0.69834124
151MP0005248_abnormal_Harderian_gland0.69750817
152MP0003385_abnormal_body_wall0.69709801
153MP0002085_abnormal_embryonic_tissue0.69472655
154MP0003566_abnormal_cell_adhesion0.68797577
155MP0002114_abnormal_axial_skeleton0.68624709
156MP0010769_abnormal_survival0.68161770
157MP0000462_abnormal_digestive_system0.68081800
158MP0009840_abnormal_foam_cell0.67866040
159MP0008872_abnormal_physiological_respon0.67183821
160MP0003632_abnormal_nervous_system0.66582698
161MP0001502_abnormal_circadian_rhythm0.65808873
162MP0010368_abnormal_lymphatic_system0.65333110
163MP0003634_abnormal_glial_cell0.65155625
164MP0002108_abnormal_muscle_morphology0.65085584
165MP0003868_abnormal_feces_composition0.64926351
166MP0002080_prenatal_lethality0.64738097

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.46806820
2Myokymia (HP:0002411)4.01839727
3Protrusio acetabuli (HP:0003179)3.96424458
4Deep venous thrombosis (HP:0002625)3.90136358
5Focal seizures (HP:0007359)3.83842260
6Premature rupture of membranes (HP:0001788)3.49373094
7Neonatal short-limb short stature (HP:0008921)3.35142161
8Progressive cerebellar ataxia (HP:0002073)3.31983523
9Visual hallucinations (HP:0002367)3.20789985
10Sparse lateral eyebrow (HP:0005338)3.17422500
11Genetic anticipation (HP:0003743)3.16898729
12Anal stenosis (HP:0002025)3.10142305
13Action tremor (HP:0002345)3.04143343
14Annular pancreas (HP:0001734)3.00896874
15Abnormality of the lower motor neuron (HP:0002366)2.95104110
16Arterial tortuosity (HP:0005116)2.88320086
17Epileptic encephalopathy (HP:0200134)2.85054077
18Dysmetric saccades (HP:0000641)2.84639396
19Asymmetry of the thorax (HP:0001555)2.77226455
20Vascular tortuosity (HP:0004948)2.77054107
21Natal tooth (HP:0000695)2.71077058
22Long palpebral fissure (HP:0000637)2.70613363
23Lip pit (HP:0100267)2.69839985
24Shallow orbits (HP:0000586)2.65085013
25Atonic seizures (HP:0010819)2.63447239
26Febrile seizures (HP:0002373)2.60076400
27Amblyopia (HP:0000646)2.55055997
28Abnormality of carpal bone ossification (HP:0006257)2.54404383
29Ankyloglossia (HP:0010296)2.52000178
30Pointed chin (HP:0000307)2.46242584
31Impaired smooth pursuit (HP:0007772)2.43547473
32Intestinal fistula (HP:0100819)2.41756524
33Pterygium (HP:0001059)2.37619673
34Absence seizures (HP:0002121)2.36346865
35Flat acetabular roof (HP:0003180)2.34987607
36Urethral obstruction (HP:0000796)2.33725711
37Bladder diverticulum (HP:0000015)2.31939351
38Advanced eruption of teeth (HP:0006288)2.31254636
39Aortic dissection (HP:0002647)2.31119792
40Poor eye contact (HP:0000817)2.30509818
41Vertebral hypoplasia (HP:0008417)2.30153485
42Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.30153485
43Neonatal death (HP:0003811)2.28816922
44Obstructive sleep apnea (HP:0002870)2.26863752
45Impaired social interactions (HP:0000735)2.25234559
46Abnormal social behavior (HP:0012433)2.25234559
47Papilledema (HP:0001085)2.23206782
48Short 5th finger (HP:0009237)2.18900268
49Diplopia (HP:0000651)2.18159045
50Abnormality of binocular vision (HP:0011514)2.18159045
51Stereotypic behavior (HP:0000733)2.17931901
52Depression (HP:0000716)2.17003068
53Dysdiadochokinesis (HP:0002075)2.16111728
54Abnormality of the astrocytes (HP:0100707)2.14589914
55Astrocytoma (HP:0009592)2.14589914
56Abnormal ossification of hand bones (HP:0005921)2.13468261
57Aqueductal stenosis (HP:0002410)2.12940761
58Spinal rigidity (HP:0003306)2.11607397
59Gaze-evoked nystagmus (HP:0000640)2.11349319
60Abnormality of ocular smooth pursuit (HP:0000617)2.10697670
61Aplasia involving bones of the extremities (HP:0009825)2.08656982
62Aplasia involving bones of the upper limbs (HP:0009823)2.08656982
63Aplasia of the phalanges of the hand (HP:0009802)2.08656982
64Broad-based gait (HP:0002136)2.07989573
65Hemiplegia (HP:0002301)2.06929016
66Dialeptic seizures (HP:0011146)2.05833096
67Thin bony cortex (HP:0002753)2.05384458
68Small epiphyses (HP:0010585)2.05325006
69Insidious onset (HP:0003587)2.05180146
70Termporal pattern (HP:0011008)2.05180146
71Depressed nasal tip (HP:0000437)2.05070592
72Generalized tonic-clonic seizures (HP:0002069)2.04585054
73Disproportionate tall stature (HP:0001519)2.03124587
74Popliteal pterygium (HP:0009756)2.02829193
75Coronal craniosynostosis (HP:0004440)2.02755573
76Drooling (HP:0002307)2.02084152
77Excessive salivation (HP:0003781)2.02084152
78Macroorchidism (HP:0000053)2.00064280
79Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.99459788
80Impaired vibration sensation in the lower limbs (HP:0002166)1.97789535
81Hypoventilation (HP:0002791)1.97348776
82Obsessive-compulsive behavior (HP:0000722)1.96133731
83Lower limb asymmetry (HP:0100559)1.93549551
84Preauricular pit (HP:0004467)1.93287012
85Periauricular skin pits (HP:0100277)1.93287012
86Abnormal tarsal ossification (HP:0008369)1.93019452
87Wormian bones (HP:0002645)1.92583290
88Blue sclerae (HP:0000592)1.91986733
89Renal cell carcinoma (HP:0005584)1.91262008
90Enlarged penis (HP:0000040)1.91034219
91Trismus (HP:0000211)1.90664400
92Aortic aneurysm (HP:0004942)1.90519580
93Hypercholesterolemia (HP:0003124)1.90257347
94Hypoplasia of the capital femoral epiphysis (HP:0003090)1.89851839
95Ureteral stenosis (HP:0000071)1.89838540
96Upper limb amyotrophy (HP:0009129)1.89071707
97Distal upper limb amyotrophy (HP:0007149)1.89071707
98Neoplasm of the heart (HP:0100544)1.88993202
99Lower limb amyotrophy (HP:0007210)1.88653414
100Megalencephaly (HP:0001355)1.88271503
101Abnormality of oral frenula (HP:0000190)1.87786879
102Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.87297167
103Short 4th metacarpal (HP:0010044)1.87297167
104Abnormal hand bone ossification (HP:0010660)1.86961738
105Vertebral compression fractures (HP:0002953)1.86849366
106Hemiparesis (HP:0001269)1.85356638
107Abnormality of the acetabulum (HP:0003170)1.85345238
108Atrophic scars (HP:0001075)1.84852942
109Ankle contracture (HP:0006466)1.84309528
110Arnold-Chiari malformation (HP:0002308)1.84294723
111Abnormality of the labia minora (HP:0012880)1.84279415
112Ventricular fibrillation (HP:0001663)1.83685144
113Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.81944331
114Short 1st metacarpal (HP:0010034)1.81944331
115Truncal ataxia (HP:0002078)1.81025371
116Mucopolysacchariduria (HP:0008155)1.80892677
117Urinary glycosaminoglycan excretion (HP:0003541)1.80892677
118Truncus arteriosus (HP:0001660)1.79883355
119Ependymoma (HP:0002888)1.79674461
120Back pain (HP:0003418)1.79211362
121Hemorrhage of the eye (HP:0011885)1.79024692
122Urinary bladder sphincter dysfunction (HP:0002839)1.78919563
123Shawl scrotum (HP:0000049)1.78445396
124Abnormality of the distal phalanges of the toes (HP:0010182)1.78373444
125Genu recurvatum (HP:0002816)1.78073492
126Elfin facies (HP:0004428)1.77478571
127Abnormality of the fingertips (HP:0001211)1.77358398
128Dysmetria (HP:0001310)1.77180649
129Renovascular hypertension (HP:0100817)1.76936678
130Hyperacusis (HP:0010780)1.76281716
131Fragile skin (HP:0001030)1.76252097
132Xanthomatosis (HP:0000991)1.75719771
133Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.75099092
134Bundle branch block (HP:0011710)1.74191011
135Trigonocephaly (HP:0000243)1.73829577
136Intellectual disability, profound (HP:0002187)1.72788656
137Abnormality of the aortic arch (HP:0012303)1.72726518
138Broad face (HP:0000283)1.72159381
139Insomnia (HP:0100785)1.71849411
140Renal duplication (HP:0000075)1.71276421
141Prolonged partial thromboplastin time (HP:0003645)1.71077060
142Increased nuchal translucency (HP:0010880)1.70444077
143Aplasia/Hypoplasia of the scapulae (HP:0006713)1.70342667
144Hypoplastic scapulae (HP:0000882)1.70342667
145Postural instability (HP:0002172)1.70045007
146Abnormal eating behavior (HP:0100738)1.68395553
147Attention deficit hyperactivity disorder (HP:0007018)1.68274592
148Hyperthyroidism (HP:0000836)1.67516649
149Milia (HP:0001056)1.67102321
150Uterine leiomyosarcoma (HP:0002891)1.66916603
151Leiomyosarcoma (HP:0100243)1.66916603
152Skin nodule (HP:0200036)1.66532442
153Broad thumb (HP:0011304)1.66197920
154Microglossia (HP:0000171)1.66078948
155Coxa vara (HP:0002812)1.65250773
156Hammertoe (HP:0001765)1.63828388
157Cervical subluxation (HP:0003308)1.63523303
158Ureteral obstruction (HP:0006000)1.62693391
159Cerebral aneurysm (HP:0004944)1.62141089
160Bronchomalacia (HP:0002780)1.61925696
161Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.61524664
162Mutism (HP:0002300)1.61025958
163Protruding ear (HP:0000411)1.60748166
164Abnormal delivery (HP:0001787)1.60678306
165Abnormality of mucopolysaccharide metabolism (HP:0011020)1.60205174
166Abnormality of polysaccharide metabolism (HP:0011012)1.60205174
167Abnormality of glycosaminoglycan metabolism (HP:0004371)1.60205174
168Rapidly progressive (HP:0003678)1.60121949
169Overriding aorta (HP:0002623)1.60103008
170Wide anterior fontanel (HP:0000260)1.59826557
171Achilles tendon contracture (HP:0001771)1.59801870
172Short phalanx of the thumb (HP:0009660)1.59256670
173Hydroureter (HP:0000072)1.59060458
174Thin ribs (HP:0000883)1.59053612
175Mitral regurgitation (HP:0001653)1.59032130
176Neurofibrillary tangles (HP:0002185)1.59015060
177Hand muscle atrophy (HP:0009130)1.58853099
178Dysostosis multiplex (HP:0000943)1.58734721
179Narrow palate (HP:0000189)1.57705685
180Supranuclear gaze palsy (HP:0000605)1.57578643
181Exotropia (HP:0000577)1.54574729
182Absent speech (HP:0001344)1.53849732
183Glioma (HP:0009733)1.53839479
184Volvulus (HP:0002580)1.53790334
185Shoulder girdle muscle weakness (HP:0003547)1.53730357
186Esophageal atresia (HP:0002032)1.52925648
187Broad palm (HP:0001169)1.52786528
188Agitation (HP:0000713)1.52685686
189Postural tremor (HP:0002174)1.51857182
190Abnormality of the 1st metacarpal (HP:0010009)1.50064768
191Turricephaly (HP:0000262)1.49602899

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK244.17752348
2NTRK33.72888401
3WNK43.53052819
4EPHA23.39260420
5EPHA43.33393625
6MAP3K93.28288902
7STK393.13149853
8MST1R2.69381167
9LATS22.28151605
10PRKD32.27638031
11MAP3K42.23889771
12MINK12.22862324
13CDK122.17182276
14MET2.11425109
15RIPK12.10769858
16NTRK12.09379084
17PAK62.01782274
18IRAK32.00855910
19DAPK21.96856501
20KSR21.94881888
21MAP3K31.93501583
22SIK11.85803595
23CCNB11.84481568
24TAOK11.77986744
25KSR11.75528728
26TRIB31.71458789
27CAMKK11.65053211
28MAP3K21.64070236
29ALK1.59411198
30NTRK21.58315020
31DAPK11.58220232
32STK381.57923244
33DMPK1.54695205
34ERBB41.53507265
35MAP2K41.52296350
36FGFR41.47611254
37TYRO31.43591091
38ERN11.38372523
39SIK21.36142332
40PLK21.28935408
41NEK11.25428140
42PKN21.21390899
43EEF2K1.21312782
44PNCK1.18485530
45WEE11.18236827
46CDK51.16250220
47ICK1.14581785
48PDGFRA1.14394581
49MARK11.13848361
50ILK1.12616302
51RET1.12239789
52PTK21.11349546
53LATS11.08216104
54PTK2B1.08126080
55BMX1.04045584
56CAMK1G1.03502589
57STK111.03062814
58MARK21.00572914
59RIPK40.99704846
60MAP3K120.98227996
61TTK0.97805074
62SIK30.95535391
63MAP2K70.93404457
64AKT30.92357355
65EIF2AK10.91704940
66CDC70.91301067
67GRK50.89152552
68CAMK10.88476045
69MAP3K70.87243991
70UHMK10.85919710
71EPHB20.85007643
72SCYL20.83374234
73SGK30.80631024
74FER0.80035929
75BRSK10.78967510
76MAPKAPK30.77843187
77CDK180.77099817
78CDK190.76590730
79CDK140.76181954
80PRKCH0.76128839
81CDK80.75789149
82PRKCG0.74902300
83CDK70.74220993
84CDK150.73426670
85DDR20.73149388
86PAK30.72911414
87CHEK20.71910665
88CAMK40.71846764
89LMTK20.67572954
90CDK90.67306153
91SGK10.66987956
92PRKD20.65676461
93MOS0.64831128
94CDK11A0.64727780
95FGFR10.62984887
96SGK20.62694570
97MTOR0.61201014
98TESK10.60769953
99PINK10.59216184
100WNK30.57574239
101MAP3K100.57468451
102CSNK1E0.56728843
103CDC42BPA0.56572039
104ARAF0.56502014
105MAPK100.55940946
106CAMK2A0.55304866
107RPS6KA30.53947680
108MAP3K10.53922144
109CDK60.50934571
110PDGFRB0.49916989
111PRPF4B0.49307210
112MAP2K10.49032488
113CAMK1D0.48373668
114WNK10.48262408
115CAMKK20.47636677
116RPS6KL10.47062543
117RPS6KC10.47062543
118PTK60.45281498
119BRD40.45183678
120MELK0.44580821
121MAPK80.43681686
122FLT30.43350426
123PAK40.42861469
124PAK20.42797481
125FES0.42617194
126NEK90.41636584
127RPS6KA20.41493323
128LIMK10.41252017
129MAPKAPK50.40658234
130MAP3K60.40458383
131PDK10.40150485
132JAK30.40143494
133SRPK10.39474076
134GSK3B0.39272376
135SRC0.39165877
136TGFBR20.39165430
137SMG10.38517664
138MAP3K130.38430120
139EIF2AK20.38075546
140DYRK1A0.37890497
141RPS6KB20.36638437
142TRPM70.36138596
143MAP3K80.36124516
144NEK20.36032300
145MAPK110.35757829
146AKT20.35463372
147FGFR30.33501485
148BRSK20.29889002

Predicted pathways (KEGG)

RankGene SetZ-score
1Long-term potentiation_Homo sapiens_hsa047202.45388193
2Nicotine addiction_Homo sapiens_hsa050332.40005838
3ECM-receptor interaction_Homo sapiens_hsa045122.37438827
4Arginine biosynthesis_Homo sapiens_hsa002202.26495206
5Circadian entrainment_Homo sapiens_hsa047132.10898311
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.09270357
7Glutamatergic synapse_Homo sapiens_hsa047241.98640634
8Synaptic vesicle cycle_Homo sapiens_hsa047211.97240326
9Complement and coagulation cascades_Homo sapiens_hsa046101.95517288
10Amphetamine addiction_Homo sapiens_hsa050311.94930788
11Olfactory transduction_Homo sapiens_hsa047401.86553388
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.81100787
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.79151062
14Salivary secretion_Homo sapiens_hsa049701.75215245
15GABAergic synapse_Homo sapiens_hsa047271.71807991
16Steroid biosynthesis_Homo sapiens_hsa001001.71360564
17Dopaminergic synapse_Homo sapiens_hsa047281.71305304
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.65338865
19Morphine addiction_Homo sapiens_hsa050321.64241917
20Gastric acid secretion_Homo sapiens_hsa049711.63722877
21Nitrogen metabolism_Homo sapiens_hsa009101.61397194
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60524167
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60267867
24Long-term depression_Homo sapiens_hsa047301.57020129
25Insulin secretion_Homo sapiens_hsa049111.54560984
26Lysine degradation_Homo sapiens_hsa003101.52418106
27Glioma_Homo sapiens_hsa052141.50416754
28Cholinergic synapse_Homo sapiens_hsa047251.49846050
29Prion diseases_Homo sapiens_hsa050201.48350474
30Oxytocin signaling pathway_Homo sapiens_hsa049211.48217994
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.47602139
32Fatty acid biosynthesis_Homo sapiens_hsa000611.46298824
33AMPK signaling pathway_Homo sapiens_hsa041521.46268756
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44103839
35GnRH signaling pathway_Homo sapiens_hsa049121.40814668
36Estrogen signaling pathway_Homo sapiens_hsa049151.38807505
37Gap junction_Homo sapiens_hsa045401.34366687
38Renin secretion_Homo sapiens_hsa049241.33371247
39Melanogenesis_Homo sapiens_hsa049161.29030119
40Small cell lung cancer_Homo sapiens_hsa052221.28653584
41Dorso-ventral axis formation_Homo sapiens_hsa043201.27123635
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26508757
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26234880
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.22733527
45mTOR signaling pathway_Homo sapiens_hsa041501.22270992
46Bile secretion_Homo sapiens_hsa049761.22110834
47Vitamin B6 metabolism_Homo sapiens_hsa007501.21923905
48ErbB signaling pathway_Homo sapiens_hsa040121.18942562
49Thyroid hormone signaling pathway_Homo sapiens_hsa049191.18824188
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.18704441
51Calcium signaling pathway_Homo sapiens_hsa040201.18528405
52cAMP signaling pathway_Homo sapiens_hsa040241.17110729
53Axon guidance_Homo sapiens_hsa043601.16265775
54Oocyte meiosis_Homo sapiens_hsa041141.14068116
55VEGF signaling pathway_Homo sapiens_hsa043701.12279559
56Cocaine addiction_Homo sapiens_hsa050301.11760684
57Taste transduction_Homo sapiens_hsa047421.11653314
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11071270
59Type II diabetes mellitus_Homo sapiens_hsa049301.10981393
60N-Glycan biosynthesis_Homo sapiens_hsa005101.10136837
61Neurotrophin signaling pathway_Homo sapiens_hsa047221.09960378
62Dilated cardiomyopathy_Homo sapiens_hsa054141.08241913
63Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08090418
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07604080
65Endometrial cancer_Homo sapiens_hsa052131.06737910
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06734486
67cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06729587
68Adherens junction_Homo sapiens_hsa045201.04726342
69PPAR signaling pathway_Homo sapiens_hsa033201.02808563
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.02567566
71Notch signaling pathway_Homo sapiens_hsa043301.01018073
72Hippo signaling pathway_Homo sapiens_hsa043901.00606956
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99969211
74Colorectal cancer_Homo sapiens_hsa052100.99612889
75Wnt signaling pathway_Homo sapiens_hsa043100.99173697
76Choline metabolism in cancer_Homo sapiens_hsa052310.98440868
77Serotonergic synapse_Homo sapiens_hsa047260.97937370
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.96822180
79Amoebiasis_Homo sapiens_hsa051460.95043555
80Rap1 signaling pathway_Homo sapiens_hsa040150.94850821
81PI3K-Akt signaling pathway_Homo sapiens_hsa041510.93560738
82Prostate cancer_Homo sapiens_hsa052150.92737874
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91590941
84Non-small cell lung cancer_Homo sapiens_hsa052230.89947074
85Protein digestion and absorption_Homo sapiens_hsa049740.89861219
86MAPK signaling pathway_Homo sapiens_hsa040100.89433034
87Biosynthesis of amino acids_Homo sapiens_hsa012300.89078351
88Proteoglycans in cancer_Homo sapiens_hsa052050.86960519
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86879332
90Renal cell carcinoma_Homo sapiens_hsa052110.86838011
91Other glycan degradation_Homo sapiens_hsa005110.85412025
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85202357
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83687303
94Chronic myeloid leukemia_Homo sapiens_hsa052200.82492767
95Arginine and proline metabolism_Homo sapiens_hsa003300.82327899
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.82153520
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81574795
98Glucagon signaling pathway_Homo sapiens_hsa049220.81503512
99Basal cell carcinoma_Homo sapiens_hsa052170.79807712
100Vibrio cholerae infection_Homo sapiens_hsa051100.79546988
101Thyroid cancer_Homo sapiens_hsa052160.78817677
102Focal adhesion_Homo sapiens_hsa045100.78693323
103Hedgehog signaling pathway_Homo sapiens_hsa043400.78456219
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78099251
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.75901316
106Thyroid hormone synthesis_Homo sapiens_hsa049180.75009739
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.74886782
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73933848
109Fat digestion and absorption_Homo sapiens_hsa049750.73803022
110Fatty acid metabolism_Homo sapiens_hsa012120.73089064
111Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.73007850
112Pancreatic secretion_Homo sapiens_hsa049720.71410113
113mRNA surveillance pathway_Homo sapiens_hsa030150.71293033
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71265775
115MicroRNAs in cancer_Homo sapiens_hsa052060.70410617
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69791811
117Insulin signaling pathway_Homo sapiens_hsa049100.66339673
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.65955423
119Pathways in cancer_Homo sapiens_hsa052000.65656431
120Bladder cancer_Homo sapiens_hsa052190.65406002
121Ras signaling pathway_Homo sapiens_hsa040140.65088989
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64970917
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63713894
124Fructose and mannose metabolism_Homo sapiens_hsa000510.63603634
125Tight junction_Homo sapiens_hsa045300.63166581
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61688968
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61377792
128Melanoma_Homo sapiens_hsa052180.61035545
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59090025
130Endocytosis_Homo sapiens_hsa041440.58776455
131HIF-1 signaling pathway_Homo sapiens_hsa040660.58254822
132Inositol phosphate metabolism_Homo sapiens_hsa005620.57003136
133Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56710043
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.56448542
135TGF-beta signaling pathway_Homo sapiens_hsa043500.54356692
136Platelet activation_Homo sapiens_hsa046110.52916094
137Pancreatic cancer_Homo sapiens_hsa052120.51823030
138Insulin resistance_Homo sapiens_hsa049310.49632657
139Sphingolipid metabolism_Homo sapiens_hsa006000.49392670
140Pyruvate metabolism_Homo sapiens_hsa006200.48720373
141Cell cycle_Homo sapiens_hsa041100.48523606
142Sulfur metabolism_Homo sapiens_hsa009200.46963562

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