SPRED3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with a C-terminal Sprouty-like cysteine-rich domain (SRY) and an N-terminal Ena/Vasodilator-stimulated phosphoprotein (VASP) homology-1 (EVH-1) domain. The encoded protein is a member of a family of proteins that negatively regulates mitogen-activated protein (MAP) kinase signaling, particularly during organogenesis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.01684843
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.08195000
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.04505542
4synaptic vesicle maturation (GO:0016188)4.98955877
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.97585603
6protein localization to synapse (GO:0035418)4.92347869
7vocalization behavior (GO:0071625)4.77784106
8postsynaptic membrane organization (GO:0001941)4.62313021
9locomotory exploration behavior (GO:0035641)4.51431430
10ionotropic glutamate receptor signaling pathway (GO:0035235)4.47628158
11regulation of glutamate receptor signaling pathway (GO:1900449)4.47529207
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.46433450
13neuron cell-cell adhesion (GO:0007158)4.45430285
14regulation of synaptic vesicle exocytosis (GO:2000300)4.25042850
15synaptic transmission, glutamatergic (GO:0035249)4.17004682
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.05447853
17synaptic vesicle exocytosis (GO:0016079)4.05148221
18neurotransmitter-gated ion channel clustering (GO:0072578)4.04703203
19pyrimidine nucleobase catabolic process (GO:0006208)4.04602051
20neuronal action potential propagation (GO:0019227)4.03187856
21presynaptic membrane assembly (GO:0097105)3.99114217
22glutamate receptor signaling pathway (GO:0007215)3.98033027
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.88569399
24glutamate secretion (GO:0014047)3.88198838
25regulation of synaptic vesicle transport (GO:1902803)3.85217413
26regulation of neuronal synaptic plasticity (GO:0048168)3.80027773
27L-fucose catabolic process (GO:0042355)3.77576117
28fucose catabolic process (GO:0019317)3.77576117
29L-fucose metabolic process (GO:0042354)3.77576117
30regulation of long-term neuronal synaptic plasticity (GO:0048169)3.77176562
31negative regulation of synaptic transmission, GABAergic (GO:0032229)3.74621969
32cellular response to ATP (GO:0071318)3.73651649
33neuron-neuron synaptic transmission (GO:0007270)3.69465325
34positive regulation of synaptic transmission, GABAergic (GO:0032230)3.64819769
35regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.64111819
36exploration behavior (GO:0035640)3.59893777
37auditory behavior (GO:0031223)3.59284787
38dendritic spine morphogenesis (GO:0060997)3.59179494
39presynaptic membrane organization (GO:0097090)3.54168319
40long-term memory (GO:0007616)3.50227064
41G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.46372893
42layer formation in cerebral cortex (GO:0021819)3.45388445
43positive regulation of membrane potential (GO:0045838)3.42859938
44startle response (GO:0001964)3.42274512
45nucleobase catabolic process (GO:0046113)3.37357829
46epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.37074823
47positive regulation of dendritic spine morphogenesis (GO:0061003)3.36649715
48regulation of synapse structural plasticity (GO:0051823)3.33015713
49neurotransmitter secretion (GO:0007269)3.31292425
50positive regulation of neurotransmitter secretion (GO:0001956)3.30525318
51regulation of excitatory postsynaptic membrane potential (GO:0060079)3.30441012
52response to pheromone (GO:0019236)3.29006346
53central nervous system projection neuron axonogenesis (GO:0021952)3.28528179
54negative regulation of telomere maintenance (GO:0032205)3.27798200
55behavioral response to ethanol (GO:0048149)3.26859874
56kynurenine metabolic process (GO:0070189)3.22090684
57positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.21527887
58regulation of action potential (GO:0098900)3.21365606
59negative regulation of mast cell activation (GO:0033004)3.20261310
60regulation of respiratory system process (GO:0044065)3.18304871
61protein polyglutamylation (GO:0018095)3.18274498
62response to auditory stimulus (GO:0010996)3.17740750
63regulation of neurotransmitter secretion (GO:0046928)3.17200462
64righting reflex (GO:0060013)3.16351211
65regulation of postsynaptic membrane potential (GO:0060078)3.15858505
66regulation of respiratory gaseous exchange (GO:0043576)3.15228823
67dendrite morphogenesis (GO:0048813)3.12166257
68regulation of synaptic transmission, glutamatergic (GO:0051966)3.11537298
69membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.11433379
70positive regulation of dendritic spine development (GO:0060999)3.10320136
71response to gravity (GO:0009629)3.07263437
72neuron recognition (GO:0008038)3.05450698
73neuronal action potential (GO:0019228)3.05328027
74transmission of nerve impulse (GO:0019226)3.03917356
75regulation of neurotransmitter uptake (GO:0051580)3.03780097
76regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.03492363
77negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.03083833
78gamma-aminobutyric acid transport (GO:0015812)3.02784707
79indolalkylamine metabolic process (GO:0006586)3.02221518
80positive regulation of neurotransmitter transport (GO:0051590)3.02081865
81mechanosensory behavior (GO:0007638)3.01439483
82regulation of synaptic transmission, GABAergic (GO:0032228)3.01136164
83L-amino acid import (GO:0043092)2.99523759
84cerebral cortex radially oriented cell migration (GO:0021799)2.98702545
85synaptic vesicle endocytosis (GO:0048488)2.98539601
86detection of light stimulus involved in sensory perception (GO:0050962)2.97885756
87detection of light stimulus involved in visual perception (GO:0050908)2.97885756
88platelet dense granule organization (GO:0060155)2.97654418
89tryptophan catabolic process (GO:0006569)2.96849309
90indole-containing compound catabolic process (GO:0042436)2.96849309
91indolalkylamine catabolic process (GO:0046218)2.96849309
92regulation of dendritic spine morphogenesis (GO:0061001)2.95561615
93cornea development in camera-type eye (GO:0061303)2.92498115
94regulation of synaptic plasticity (GO:0048167)2.91460050
95learning (GO:0007612)2.89996979
96regulation of neurotransmitter transport (GO:0051588)2.89029552
97cellular potassium ion homeostasis (GO:0030007)2.88837072
98synaptic transmission, cholinergic (GO:0007271)2.87928614
99proline transport (GO:0015824)2.85034543
100neurotransmitter transport (GO:0006836)2.83440246
101membrane depolarization during action potential (GO:0086010)2.83403945
102neuromuscular synaptic transmission (GO:0007274)2.83019379
103nonmotile primary cilium assembly (GO:0035058)2.82961661
104detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.82330475
105long-term synaptic potentiation (GO:0060291)2.82176218
106axonal fasciculation (GO:0007413)2.81748290
107central nervous system neuron axonogenesis (GO:0021955)2.81033914
108regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.80418287
109synapse assembly (GO:0007416)2.79262922
110kidney morphogenesis (GO:0060993)2.75503389
111gamma-aminobutyric acid signaling pathway (GO:0007214)2.74640053
112retinal ganglion cell axon guidance (GO:0031290)2.73950196
113positive regulation of synapse assembly (GO:0051965)2.73836375
114visual learning (GO:0008542)2.72004727
115cranial nerve structural organization (GO:0021604)2.71872473
116neuronal ion channel clustering (GO:0045161)2.70780998
117regulation of cilium movement (GO:0003352)2.70187290
118regulation of vesicle fusion (GO:0031338)2.69217186
119facial nerve structural organization (GO:0021612)2.68594323
120protein-cofactor linkage (GO:0018065)2.68342033
121glycerophospholipid catabolic process (GO:0046475)2.67928592
122dendritic spine organization (GO:0097061)2.67535342
123innervation (GO:0060384)2.67495243
124membrane depolarization (GO:0051899)2.66471694
125glycosphingolipid biosynthetic process (GO:0006688)2.65572369
126cerebellar Purkinje cell differentiation (GO:0021702)2.65381053
127regulation of dendritic spine development (GO:0060998)2.64149825
128cellular ketone body metabolic process (GO:0046950)2.63728309
129regulation of nuclear cell cycle DNA replication (GO:0033262)2.63467366
130negative regulation of cytosolic calcium ion concentration (GO:0051481)2.62648492
131reflex (GO:0060004)2.62572215
132regulation of synapse maturation (GO:0090128)2.62178614
133amino acid import (GO:0043090)2.62080670
134calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.61109904
135visual behavior (GO:0007632)2.60683452
136positive regulation of synaptic transmission (GO:0050806)2.60001640
137adult walking behavior (GO:0007628)2.59797115
138membrane hyperpolarization (GO:0060081)2.59231569
139photoreceptor cell development (GO:0042461)2.58767383
140piRNA metabolic process (GO:0034587)2.57477548
141regulation of synaptic transmission (GO:0050804)2.56845313
142regulation of telomere maintenance (GO:0032204)2.55864107
143regulation of synapse assembly (GO:0051963)2.55690421
144epithelial cilium movement (GO:0003351)2.54527473
145preassembly of GPI anchor in ER membrane (GO:0016254)2.54178650
146cAMP catabolic process (GO:0006198)2.51681787
147tryptophan metabolic process (GO:0006568)2.51200845
148negative regulation of axon guidance (GO:1902668)2.49903492
149cilium morphogenesis (GO:0060271)2.47983006
150inner ear receptor stereocilium organization (GO:0060122)2.47681397
151regulation of hippo signaling (GO:0035330)2.47371836
152protein localization to cilium (GO:0061512)2.46879950
153primary amino compound metabolic process (GO:1901160)2.46743030
154indole-containing compound metabolic process (GO:0042430)2.45669388
155protein import into peroxisome matrix (GO:0016558)2.45122442
156axoneme assembly (GO:0035082)2.44026365
157amine catabolic process (GO:0009310)2.42317614
158cellular biogenic amine catabolic process (GO:0042402)2.42317614
159rRNA catabolic process (GO:0016075)2.40840161
160regulation of rhodopsin mediated signaling pathway (GO:0022400)2.40067364
161rhodopsin mediated signaling pathway (GO:0016056)2.39637523
162retinal cone cell development (GO:0046549)2.39610321
163regulation of microtubule-based movement (GO:0060632)2.39204133
164detection of mechanical stimulus involved in sensory perception (GO:0050974)2.39135452
165water-soluble vitamin biosynthetic process (GO:0042364)2.38265824
166nephron tubule morphogenesis (GO:0072078)2.33605180
167nephron epithelium morphogenesis (GO:0072088)2.33605180
168positive regulation of action potential (GO:0045760)2.32582826
169cyclic nucleotide catabolic process (GO:0009214)2.32162460

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.05753635
2GBX2_23144817_ChIP-Seq_PC3_Human4.00656841
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09650442
4VDR_22108803_ChIP-Seq_LS180_Human2.99571252
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.90471190
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69650656
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.68345580
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61414101
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61414101
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56905515
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.55971587
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.51205806
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50443259
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.43088168
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37272055
16* REST_21632747_ChIP-Seq_MESCs_Mouse2.29469693
17CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.26280475
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23677107
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.21990258
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17097201
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.16674816
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.16247853
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.13632251
24DROSHA_22980978_ChIP-Seq_HELA_Human2.09865258
25SMAD_19615063_ChIP-ChIP_OVARY_Human2.00917954
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84466011
27AR_21572438_ChIP-Seq_LNCaP_Human1.81382296
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.75378448
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75346063
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.73024404
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72351595
32IGF1R_20145208_ChIP-Seq_DFB_Human1.72196487
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.70175807
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.67118432
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.65798026
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63755766
37* REST_18959480_ChIP-ChIP_MESCs_Mouse1.60377125
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.58315588
39SMAD4_21799915_ChIP-Seq_A2780_Human1.57867413
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56067431
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.55034004
42EWS_26573619_Chip-Seq_HEK293_Human1.53619038
43RNF2_27304074_Chip-Seq_NSC_Mouse1.50554176
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50250736
45P300_19829295_ChIP-Seq_ESCs_Human1.49884742
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48043972
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47812088
48CBP_20019798_ChIP-Seq_JUKART_Human1.47812088
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47458320
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.47197160
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44663388
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43884203
53TAF15_26573619_Chip-Seq_HEK293_Human1.41468964
54CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40958728
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.32851687
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32454397
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.32178065
58TP53_22573176_ChIP-Seq_HFKS_Human1.28992047
59FUS_26573619_Chip-Seq_HEK293_Human1.26023170
60BCAT_22108803_ChIP-Seq_LS180_Human1.24881851
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24826433
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24769414
63EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23448159
64ETV2_25802403_ChIP-Seq_MESCs_Mouse1.22513785
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21823120
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21485905
67RING1B_27294783_Chip-Seq_NPCs_Mouse1.21215119
68RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21134000
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17396875
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17225538
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16175790
72AR_25329375_ChIP-Seq_VCAP_Human1.15279546
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14760849
74JUN_21703547_ChIP-Seq_K562_Human1.14392640
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13566971
76FLI1_27457419_Chip-Seq_LIVER_Mouse1.13514258
77STAT3_23295773_ChIP-Seq_U87_Human1.11831217
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.11656426
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11644615
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11347732
81TCF4_22108803_ChIP-Seq_LS180_Human1.11190917
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.10883315
83TCF4_23295773_ChIP-Seq_U87_Human1.10680078
84E2F1_18555785_Chip-Seq_ESCs_Mouse1.08928008
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06830143
86CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06781742
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04738260
88PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04608254
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.04420608
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.03850420
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03827276
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03611501
93ZNF274_21170338_ChIP-Seq_K562_Hela1.03293455
94RUNX2_22187159_ChIP-Seq_PCA_Human1.03064251
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02894455
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02537358
97TP53_18474530_ChIP-ChIP_U2OS_Human1.01876777
98* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01643555
99SMAD4_21741376_ChIP-Seq_EPCs_Human1.01517589
100ER_23166858_ChIP-Seq_MCF-7_Human1.01218989
101TP53_16413492_ChIP-PET_HCT116_Human1.01077527
102MYC_18940864_ChIP-ChIP_HL60_Human1.00776808
103RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00409880
104WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00318648
105FLI1_21867929_ChIP-Seq_TH2_Mouse0.99600521
106YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99522438
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98824602
108SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.98727408
109SMAD3_21741376_ChIP-Seq_HESCs_Human0.98478352
110GATA3_21878914_ChIP-Seq_MCF-7_Human0.98056418
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97997282
112AR_19668381_ChIP-Seq_PC3_Human0.97354312
113TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97276737
114CMYC_18555785_Chip-Seq_ESCs_Mouse0.96034635
115P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95575658
116P53_22387025_ChIP-Seq_ESCs_Mouse0.95315140
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94720171
118TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94148723
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94148723
120ERG_21242973_ChIP-ChIP_JURKAT_Human0.93996599
121CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93199746
122SOX2_21211035_ChIP-Seq_LN229_Gbm0.93039401
123AHR_22903824_ChIP-Seq_MCF-7_Human0.92653791
124SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92539096
125* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91320427
126SMAD3_21741376_ChIP-Seq_ESCs_Human0.90487794
127MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90343578
128SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90093653
129P300_18555785_Chip-Seq_ESCs_Mouse0.88917700

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.22186842
2MP0003880_abnormal_central_pattern4.42582454
3MP0003635_abnormal_synaptic_transmissio3.41171597
4MP0004270_analgesia3.23744236
5MP0005423_abnormal_somatic_nervous3.02225055
6MP0009745_abnormal_behavioral_response2.83410348
7MP0001188_hyperpigmentation2.79879013
8MP0002063_abnormal_learning/memory/cond2.74648501
9MP0001486_abnormal_startle_reflex2.67834038
10MP0001968_abnormal_touch/_nociception2.54539903
11MP0002064_seizures2.45159349
12MP0009046_muscle_twitch2.41106823
13MP0002572_abnormal_emotion/affect_behav2.39532706
14MP0005409_darkened_coat_color2.26995292
15MP0002734_abnormal_mechanical_nocicepti2.26302590
16MP0006292_abnormal_olfactory_placode2.22617974
17MP0002272_abnormal_nervous_system2.15082521
18MP0008877_abnormal_DNA_methylation1.97940646
19MP0002736_abnormal_nociception_after1.93872775
20MP0000778_abnormal_nervous_system1.91989671
21MP0003787_abnormal_imprinting1.85106727
22MP0004133_heterotaxia1.82978458
23MP0002067_abnormal_sensory_capabilities1.77420212
24MP0005646_abnormal_pituitary_gland1.75028481
25MP0006072_abnormal_retinal_apoptosis1.74641322
26MP0002557_abnormal_social/conspecific_i1.73557749
27MP0002735_abnormal_chemical_nociception1.71438723
28MP0005171_absent_coat_pigmentation1.67577072
29MP0002653_abnormal_ependyma_morphology1.67192384
30MP0002184_abnormal_innervation1.66589870
31MP0008569_lethality_at_weaning1.66488777
32MP0005645_abnormal_hypothalamus_physiol1.64803637
33MP0000569_abnormal_digit_pigmentation1.61667961
34MP0008872_abnormal_physiological_respon1.61032894
35MP0000015_abnormal_ear_pigmentation1.60370341
36MP0002822_catalepsy1.59879932
37MP0001502_abnormal_circadian_rhythm1.56578638
38MP0003136_yellow_coat_color1.54412113
39MP0003122_maternal_imprinting1.52233681
40MP0002733_abnormal_thermal_nociception1.51656788
41MP0004043_abnormal_pH_regulation1.50975780
42MP0002638_abnormal_pupillary_reflex1.49675135
43MP0003195_calcinosis1.48142418
44MP0001970_abnormal_pain_threshold1.48074777
45MP0001984_abnormal_olfaction1.45310135
46MP0003879_abnormal_hair_cell1.45022189
47MP0001501_abnormal_sleep_pattern1.44328818
48MP0008875_abnormal_xenobiotic_pharmacok1.43818567
49MP0004811_abnormal_neuron_physiology1.41777124
50MP0000427_abnormal_hair_cycle1.36118986
51MP0004742_abnormal_vestibular_system1.35585795
52MP0006276_abnormal_autonomic_nervous1.35466823
53MP0001440_abnormal_grooming_behavior1.35437163
54MP0003646_muscle_fatigue1.34219931
55MP0000955_abnormal_spinal_cord1.33965484
56MP0002882_abnormal_neuron_morphology1.31853692
57MP0004885_abnormal_endolymph1.27913383
58MP0002102_abnormal_ear_morphology1.27259888
59MP0004142_abnormal_muscle_tone1.26419422
60MP0005386_behavior/neurological_phenoty1.21538603
61MP0004924_abnormal_behavior1.21538603
62MP0004858_abnormal_nervous_system1.17949073
63MP0000631_abnormal_neuroendocrine_gland1.12879327
64MP0002938_white_spotting1.11711075
65MP0008775_abnormal_heart_ventricle1.11051744
66MP0001177_atelectasis1.10499914
67MP0002066_abnormal_motor_capabilities/c1.07334885
68MP0002234_abnormal_pharynx_morphology1.04282242
69MP0002928_abnormal_bile_duct1.04116808
70MP0010386_abnormal_urinary_bladder1.03319560
71MP0005174_abnormal_tail_pigmentation1.02421928
72MP0001963_abnormal_hearing_physiology1.02277975
73MP0003011_delayed_dark_adaptation1.01509988
74MP0005551_abnormal_eye_electrophysiolog1.00843630
75MP0002152_abnormal_brain_morphology0.99010245
76MP0010368_abnormal_lymphatic_system0.98497267
77MP0001905_abnormal_dopamine_level0.98436567
78MP0005394_taste/olfaction_phenotype0.97027715
79MP0005499_abnormal_olfactory_system0.97027715
80MP0005195_abnormal_posterior_eye0.96587229
81MP0000013_abnormal_adipose_tissue0.95144997
82MP0005167_abnormal_blood-brain_barrier0.94708208
83MP0005623_abnormal_meninges_morphology0.94409306
84MP0002752_abnormal_somatic_nervous0.91688900
85MP0000026_abnormal_inner_ear0.90884501
86MP0001348_abnormal_lacrimal_gland0.90507730
87MP0004147_increased_porphyrin_level0.89972489
88MP0005084_abnormal_gallbladder_morpholo0.89579191
89MP0000230_abnormal_systemic_arterial0.87614182
90MP0002089_abnormal_postnatal_growth/wei0.87191424
91MP0003890_abnormal_embryonic-extraembry0.86934333
92MP0002909_abnormal_adrenal_gland0.84351660
93MP0005503_abnormal_tendon_morphology0.83024177
94MP0002751_abnormal_autonomic_nervous0.81954181
95MP0005389_reproductive_system_phenotype0.81930671
96MP0002160_abnormal_reproductive_system0.81718544
97MP0000049_abnormal_middle_ear0.81302858
98MP0001485_abnormal_pinna_reflex0.80639597
99MP0004145_abnormal_muscle_electrophysio0.80453606
100MP0003937_abnormal_limbs/digits/tail_de0.80136766
101MP0001986_abnormal_taste_sensitivity0.79275037
102MP0001529_abnormal_vocalization0.79194263
103MP0000566_synostosis0.77592365
104MP0000372_irregular_coat_pigmentation0.77206480
105MP0003119_abnormal_digestive_system0.76986558
106MP0003633_abnormal_nervous_system0.76630105
107MP0000681_abnormal_thyroid_gland0.75890586
108MP0003950_abnormal_plasma_membrane0.74827955
109MP0009780_abnormal_chondrocyte_physiolo0.74343229
110MP0002837_dystrophic_cardiac_calcinosis0.72435098
111MP0003631_nervous_system_phenotype0.71794895
112MP0003121_genomic_imprinting0.70843767
113MP0003283_abnormal_digestive_organ0.67849934
114MP0002229_neurodegeneration0.65234068
115MP0002177_abnormal_outer_ear0.63622128
116MP0003634_abnormal_glial_cell0.62777645
117MP0005253_abnormal_eye_physiology0.62528526
118MP0003861_abnormal_nervous_system0.62388526
119MP0001943_abnormal_respiration0.62032523
120MP0003385_abnormal_body_wall0.60359471
121MP0009250_abnormal_appendicular_skeleto0.59524083
122MP0002876_abnormal_thyroid_physiology0.59442078
123MP0003632_abnormal_nervous_system0.59044025
124MP0008789_abnormal_olfactory_epithelium0.57677269
125MP0002069_abnormal_eating/drinking_beha0.57229155
126MP0005410_abnormal_fertilization0.56517187
127MP0003941_abnormal_skin_development0.55971189
128MP0002095_abnormal_skin_pigmentation0.55698468
129MP0009379_abnormal_foot_pigmentation0.54987623

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.94680856
2Febrile seizures (HP:0002373)4.51691749
3Epileptic encephalopathy (HP:0200134)4.42377019
4Myokymia (HP:0002411)4.32557388
5Pancreatic cysts (HP:0001737)4.20390388
6Abnormality of midbrain morphology (HP:0002418)4.18600946
7Molar tooth sign on MRI (HP:0002419)4.18600946
8Focal seizures (HP:0007359)3.93605141
9Pancreatic fibrosis (HP:0100732)3.89965289
10Type II lissencephaly (HP:0007260)3.72571845
11Progressive cerebellar ataxia (HP:0002073)3.66218871
12Abnormality of the renal medulla (HP:0100957)3.28073288
13Action tremor (HP:0002345)3.08268993
14Gaze-evoked nystagmus (HP:0000640)3.08147955
15Medial flaring of the eyebrow (HP:0010747)3.07230104
16Broad-based gait (HP:0002136)3.03511589
17Atonic seizures (HP:0010819)3.01777877
18Chronic hepatic failure (HP:0100626)2.92337857
19Keratoconus (HP:0000563)2.90579845
20Increased corneal curvature (HP:0100692)2.90579845
21Attenuation of retinal blood vessels (HP:0007843)2.85376183
22Retinal dysplasia (HP:0007973)2.84413124
23Tubular atrophy (HP:0000092)2.79630449
24Visual hallucinations (HP:0002367)2.78973703
25Abnormal drinking behavior (HP:0030082)2.76676113
26Polydipsia (HP:0001959)2.76676113
27Gait imbalance (HP:0002141)2.75239796
28Pendular nystagmus (HP:0012043)2.72296617
29Abnormality of the renal cortex (HP:0011035)2.69541731
30Dynein arm defect of respiratory motile cilia (HP:0012255)2.66297028
31Absent/shortened dynein arms (HP:0200106)2.66297028
32Hemiparesis (HP:0001269)2.65439487
33Cerebellar dysplasia (HP:0007033)2.63135779
34Aplasia involving bones of the extremities (HP:0009825)2.63117687
35Aplasia involving bones of the upper limbs (HP:0009823)2.63117687
36Aplasia of the phalanges of the hand (HP:0009802)2.63117687
37Cystic liver disease (HP:0006706)2.59875261
38Abolished electroretinogram (ERG) (HP:0000550)2.58986340
39Pachygyria (HP:0001302)2.57773904
40Chorioretinal atrophy (HP:0000533)2.51572724
41Genetic anticipation (HP:0003743)2.44820471
42Sclerocornea (HP:0000647)2.41785089
43Congenital primary aphakia (HP:0007707)2.38217592
44Ankle clonus (HP:0011448)2.37673973
45Nonprogressive disorder (HP:0003680)2.36433712
46Abnormality of binocular vision (HP:0011514)2.34857678
47Diplopia (HP:0000651)2.34857678
48Absence seizures (HP:0002121)2.34705096
49Mutism (HP:0002300)2.34273052
50Generalized tonic-clonic seizures (HP:0002069)2.30301513
51Supranuclear gaze palsy (HP:0000605)2.30157751
52Dialeptic seizures (HP:0011146)2.29178861
53Severe muscular hypotonia (HP:0006829)2.27695690
54Truncal ataxia (HP:0002078)2.22017217
55Blue irides (HP:0000635)2.21280995
56Nephrogenic diabetes insipidus (HP:0009806)2.16895440
57Limb dystonia (HP:0002451)2.16510928
58Poor eye contact (HP:0000817)2.15572516
59Abnormality of the pons (HP:0007361)2.15012140
60Dysdiadochokinesis (HP:0002075)2.13861660
61Abnormality of alanine metabolism (HP:0010916)2.13841083
62Hyperalaninemia (HP:0003348)2.13841083
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13841083
64Polyuria (HP:0000103)2.13719710
65Abnormal rod and cone electroretinograms (HP:0008323)2.12245045
66Septo-optic dysplasia (HP:0100842)2.11890101
67Excessive salivation (HP:0003781)2.10299826
68Drooling (HP:0002307)2.10299826
69Obstructive sleep apnea (HP:0002870)2.10003427
70Stereotypic behavior (HP:0000733)2.09194036
71Hypoplasia of the pons (HP:0012110)2.08561416
72Anxiety (HP:0000739)2.03680605
73Thyroid-stimulating hormone excess (HP:0002925)2.03329122
74Mesangial abnormality (HP:0001966)2.01986613
75Depression (HP:0000716)2.01338391
76Large for gestational age (HP:0001520)2.00741395
77Optic nerve hypoplasia (HP:0000609)2.00201491
78Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.97484995
79Congenital hepatic fibrosis (HP:0002612)1.97403995
80Agitation (HP:0000713)1.97176516
81Fetal akinesia sequence (HP:0001989)1.97151017
82EEG with generalized epileptiform discharges (HP:0011198)1.93228362
83Genital tract atresia (HP:0001827)1.92305967
84Hyperventilation (HP:0002883)1.91744319
85Bony spicule pigmentary retinopathy (HP:0007737)1.91314740
86Epileptiform EEG discharges (HP:0011182)1.90884345
87Patellar aplasia (HP:0006443)1.90793513
88Concave nail (HP:0001598)1.90516564
89Hypsarrhythmia (HP:0002521)1.90255743
90Aplasia/Hypoplasia of the patella (HP:0006498)1.90045755
91Decreased central vision (HP:0007663)1.90010920
92Small hand (HP:0200055)1.88317484
93Bradycardia (HP:0001662)1.88106768
94Aplasia/Hypoplasia of the tongue (HP:0010295)1.87453049
95Narrow forehead (HP:0000341)1.87239472
96Rib fusion (HP:0000902)1.86738154
97Vaginal atresia (HP:0000148)1.85229374
98Failure to thrive in infancy (HP:0001531)1.83739908
99Abnormal eating behavior (HP:0100738)1.83450705
100Annular pancreas (HP:0001734)1.82060679
101Furrowed tongue (HP:0000221)1.81953654
102Occipital encephalocele (HP:0002085)1.81294178
103Urinary bladder sphincter dysfunction (HP:0002839)1.81291340
104Renal cortical cysts (HP:0000803)1.81041936
105Aplasia/Hypoplasia of the tibia (HP:0005772)1.80955357
106Postaxial hand polydactyly (HP:0001162)1.80467167
107Nephronophthisis (HP:0000090)1.80359500
108Absent speech (HP:0001344)1.79648414
109Hemiplegia (HP:0002301)1.79411791
110Sleep apnea (HP:0010535)1.79039095
111Cutaneous finger syndactyly (HP:0010554)1.78830416
112Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78753544
113Anencephaly (HP:0002323)1.77615834
114Anterior segment dysgenesis (HP:0007700)1.77323297
115Hypoplasia of the fovea (HP:0007750)1.77208551
116Aplasia/Hypoplasia of the fovea (HP:0008060)1.77208551
117Deeply set eye (HP:0000490)1.75951317
118Impaired smooth pursuit (HP:0007772)1.75515737
119Polymicrogyria (HP:0002126)1.74728969
120Bulbous nose (HP:0000414)1.74441011
121Progressive inability to walk (HP:0002505)1.73928288
122Abnormal respiratory epithelium morphology (HP:0012253)1.73862744
123Abnormal respiratory motile cilium morphology (HP:0005938)1.73862744
124Torticollis (HP:0000473)1.73782738
125Spinal canal stenosis (HP:0003416)1.73707967
126Absent septum pellucidum (HP:0001331)1.72783170
127Hypoalbuminemia (HP:0003073)1.72055496
128Abnormal albumin level (HP:0012116)1.72055496
129Severe visual impairment (HP:0001141)1.71616485
130Generalized hypopigmentation of hair (HP:0011358)1.71191257
131Amblyopia (HP:0000646)1.70626461
132Abnormality of incisor morphology (HP:0011063)1.68978115
133Abnormality of ocular smooth pursuit (HP:0000617)1.67778854
134Palpebral edema (HP:0100540)1.66918866
135Abnormal biliary tract physiology (HP:0012439)1.66232622
136Bile duct proliferation (HP:0001408)1.66232622
137Dysmetria (HP:0001310)1.66007898
138Shawl scrotum (HP:0000049)1.65681588
139Abnormal ciliary motility (HP:0012262)1.65638395
140Postural instability (HP:0002172)1.65404696
141Exotropia (HP:0000577)1.65397945
142Stomach cancer (HP:0012126)1.65334777
143Protruding tongue (HP:0010808)1.64790892
144Megalencephaly (HP:0001355)1.64010822
145Long nose (HP:0003189)1.63639858
146Papilledema (HP:0001085)1.63388958
147Inappropriate behavior (HP:0000719)1.63171420
148Bradykinesia (HP:0002067)1.62600815
149Inability to walk (HP:0002540)1.62564995
150True hermaphroditism (HP:0010459)1.62121673
151Lissencephaly (HP:0001339)1.61766422
152Abnormal hair whorl (HP:0010721)1.60902006
153Abnormality of salivation (HP:0100755)1.60737548
154Absent rod-and cone-mediated responses on ERG (HP:0007688)1.60160058
155Widely spaced teeth (HP:0000687)1.59765765
156Cutaneous syndactyly (HP:0012725)1.59025243
157Polyphagia (HP:0002591)1.58232156
158Tented upper lip vermilion (HP:0010804)1.57983847
159Hypoventilation (HP:0002791)1.57374181
160Impaired vibration sensation in the lower limbs (HP:0002166)1.56833299
161Narrow nasal bridge (HP:0000446)1.55866776
162Abnormality of the septum pellucidum (HP:0007375)1.55541883
163Abnormality of the fovea (HP:0000493)1.54384385
164Tracheomalacia (HP:0002779)1.54030174
165Hypothermia (HP:0002045)1.53078964
166Congenital stationary night blindness (HP:0007642)1.52406803
167Focal dystonia (HP:0004373)1.51106252
168Aqueductal stenosis (HP:0002410)1.50827165
169Lower limb amyotrophy (HP:0007210)1.50069471

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK5.37750989
2MKNK23.93693216
3FRK3.75510266
4NTRK33.73016307
5CASK3.52525635
6MAP2K73.33180110
7MARK13.00512352
8EPHA42.86104735
9WNK42.79227564
10TAOK32.73508002
11MKNK12.45008608
12MUSK2.17959440
13ZAK2.11695641
14WNK32.01629691
15MAP3K42.01587195
16MAPK131.94773402
17TIE11.92612938
18DYRK21.90880262
19NUAK11.84370346
20MINK11.80000475
21DAPK21.77020568
22LIMK11.74862712
23PRPF4B1.72928693
24PRKD31.65677572
25MAP3K121.62874650
26MAP4K21.59702588
27NTRK21.52714678
28TLK11.49630242
29MAP3K91.46274530
30PLK21.45165821
31CAMKK11.37285252
32PAK31.37168531
33PAK61.36585782
34SGK21.36561803
35PRKCG1.30105341
36FES1.26033810
37ADRBK11.25552026
38NEK61.24369984
39CDK191.23201462
40BMPR21.22797216
41FLT31.15893969
42STK381.15345912
43CAMK11.14988390
44CDK51.14391106
45SGK4941.11778204
46SGK2231.11778204
47TNK21.09671862
48DAPK11.05514626
49TGFBR11.04971974
50PINK11.01033238
51RIPK40.99978102
52DYRK1A0.99653213
53SIK20.96368606
54STK390.95349286
55ERBB30.95207087
56CAMKK20.95063878
57PHKG20.94829047
58PHKG10.94829047
59OXSR10.88985268
60EPHB20.88429039
61SGK30.88081416
62INSRR0.85250900
63ACVR1B0.82530817
64AKT30.77248001
65GRK50.76188486
66PRKD20.75667936
67IRAK20.75610126
68MAP2K40.75509341
69UHMK10.75411834
70TRPM70.74813617
71NTRK10.74614822
72CAMK2A0.74091685
73PRKCE0.73635758
74BCR0.71933132
75TRIM280.71723982
76KSR10.71644744
77MAPKAPK30.70884000
78CSNK1G30.70501743
79CAMK1D0.70315914
80CDK30.67514668
81CSNK1G10.63336237
82MAP3K130.63263815
83SGK10.61763062
84BMPR1B0.61645329
85PRKCH0.60915954
86MAP2K60.60677410
87CDC42BPA0.60192298
88STK240.59712367
89CLK10.57473674
90ERBB40.57468386
91MARK20.57091636
92BMX0.55513947
93CSNK1G20.55058728
94MAPK150.54676623
95CDK180.52838056
96STK110.52682738
97CAMK40.52398974
98PRKCI0.51342619
99GRK70.49563113
100ADRBK20.49461132
101CDK150.49223723
102CAMK1G0.48929666
103CAMK2D0.48087080
104CAMK2B0.47319461
105CDK11A0.46687736
106PTK2B0.46598970
107EIF2AK20.46367311
108CSNK1D0.45660073
109ALK0.45185782
110CDK140.44804316
111PIK3CA0.44559498
112RPS6KB10.43675603
113GRK10.42116283
114YES10.42035966
115PRKACA0.40442211
116MAPKAPK50.40289761
117PIM20.39975217
118WNK10.38985133
119RPS6KA20.37835203
120PRKAA10.37830884
121MET0.37552706
122SIK30.37428483
123PRKCZ0.37419683
124CSNK1A10.36681327
125PRKG10.36502166
126STK38L0.35189568
127PRKCA0.34583397
128RPS6KA60.33656341
129PNCK0.33460500
130TAOK20.32891309
131IRAK30.32376069
132PKN10.31751925
133PRKG20.30102020
134LATS20.29570673
135NLK0.29214579
136RPS6KA30.28199772
137CDK80.27832925
138MAPK100.27808480
139CHEK20.27699495
140ROCK10.27682091
141GSK3B0.27454045
142CSNK1A1L0.25970813
143RAF10.25763493

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.37979004
2Olfactory transduction_Homo sapiens_hsa047402.71948335
3Synaptic vesicle cycle_Homo sapiens_hsa047212.60776292
4Circadian entrainment_Homo sapiens_hsa047132.46359112
5Morphine addiction_Homo sapiens_hsa050322.43472794
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.41555742
7Glutamatergic synapse_Homo sapiens_hsa047242.41203493
8Selenocompound metabolism_Homo sapiens_hsa004502.38470189
9GABAergic synapse_Homo sapiens_hsa047272.33525644
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.31609414
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.31431454
12Long-term potentiation_Homo sapiens_hsa047202.00129574
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.98070641
14Butanoate metabolism_Homo sapiens_hsa006501.89835313
15Amphetamine addiction_Homo sapiens_hsa050311.87956869
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.86369658
17Linoleic acid metabolism_Homo sapiens_hsa005911.86187425
18Salivary secretion_Homo sapiens_hsa049701.78492149
19Cholinergic synapse_Homo sapiens_hsa047251.74008919
20Taste transduction_Homo sapiens_hsa047421.72928780
21Insulin secretion_Homo sapiens_hsa049111.72481142
22Serotonergic synapse_Homo sapiens_hsa047261.71560457
23Dopaminergic synapse_Homo sapiens_hsa047281.67762260
24Nitrogen metabolism_Homo sapiens_hsa009101.60072661
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.59362687
26Long-term depression_Homo sapiens_hsa047301.58284895
27Caffeine metabolism_Homo sapiens_hsa002321.57950531
28Gastric acid secretion_Homo sapiens_hsa049711.45800682
29Protein export_Homo sapiens_hsa030601.44276043
30Cocaine addiction_Homo sapiens_hsa050301.43394742
31Calcium signaling pathway_Homo sapiens_hsa040201.42476400
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.42038583
33Oxytocin signaling pathway_Homo sapiens_hsa049211.40558714
34Renin secretion_Homo sapiens_hsa049241.38512443
35Ether lipid metabolism_Homo sapiens_hsa005651.38053084
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37228902
37Basal transcription factors_Homo sapiens_hsa030221.37079473
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.33736255
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.29432694
40Axon guidance_Homo sapiens_hsa043601.28218103
41Phototransduction_Homo sapiens_hsa047441.26579435
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25642255
43Oxidative phosphorylation_Homo sapiens_hsa001901.22001168
44cAMP signaling pathway_Homo sapiens_hsa040241.20119723
45GnRH signaling pathway_Homo sapiens_hsa049121.18656520
46RNA polymerase_Homo sapiens_hsa030201.17004430
47Melanogenesis_Homo sapiens_hsa049161.16624962
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.15241550
49Tryptophan metabolism_Homo sapiens_hsa003801.12159589
50Gap junction_Homo sapiens_hsa045401.11470870
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.10634347
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10322887
53ErbB signaling pathway_Homo sapiens_hsa040121.06547509
54SNARE interactions in vesicular transport_Homo sapiens_hsa041301.06293272
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06116385
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05136191
57Parkinsons disease_Homo sapiens_hsa050120.96357938
58Glioma_Homo sapiens_hsa052140.96354327
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93763598
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92690668
61Collecting duct acid secretion_Homo sapiens_hsa049660.91437748
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89514510
63Regulation of autophagy_Homo sapiens_hsa041400.88356470
64Fanconi anemia pathway_Homo sapiens_hsa034600.88267661
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88163633
66ABC transporters_Homo sapiens_hsa020100.84529708
67MAPK signaling pathway_Homo sapiens_hsa040100.83514851
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82631747
69Wnt signaling pathway_Homo sapiens_hsa043100.81713360
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81278149
71Ras signaling pathway_Homo sapiens_hsa040140.81215434
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80859968
73Type II diabetes mellitus_Homo sapiens_hsa049300.78740160
74Dilated cardiomyopathy_Homo sapiens_hsa054140.77945684
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77845198
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.77495033
77Estrogen signaling pathway_Homo sapiens_hsa049150.77042869
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76826681
79Type I diabetes mellitus_Homo sapiens_hsa049400.76429242
80RNA degradation_Homo sapiens_hsa030180.76349272
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75822383
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.74033870
83Rheumatoid arthritis_Homo sapiens_hsa053230.73177532
84Ovarian steroidogenesis_Homo sapiens_hsa049130.72756555
85Alzheimers disease_Homo sapiens_hsa050100.70956909
86Vibrio cholerae infection_Homo sapiens_hsa051100.69738445
87Rap1 signaling pathway_Homo sapiens_hsa040150.69128791
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.68962474
89Circadian rhythm_Homo sapiens_hsa047100.67746484
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66761741
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65750871
92Hippo signaling pathway_Homo sapiens_hsa043900.64652359
93One carbon pool by folate_Homo sapiens_hsa006700.63420864
94Choline metabolism in cancer_Homo sapiens_hsa052310.62434512
95Huntingtons disease_Homo sapiens_hsa050160.61866460
96Hedgehog signaling pathway_Homo sapiens_hsa043400.60631533
97Chemokine signaling pathway_Homo sapiens_hsa040620.59558218
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58343630
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58184358
100Melanoma_Homo sapiens_hsa052180.56569872
101Endometrial cancer_Homo sapiens_hsa052130.56215838
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55298547
103Colorectal cancer_Homo sapiens_hsa052100.55133383
104Homologous recombination_Homo sapiens_hsa034400.55098641
105Oocyte meiosis_Homo sapiens_hsa041140.53116796
106Thyroid hormone synthesis_Homo sapiens_hsa049180.52550085
107Primary bile acid biosynthesis_Homo sapiens_hsa001200.51308220
108Basal cell carcinoma_Homo sapiens_hsa052170.51291111
109Arachidonic acid metabolism_Homo sapiens_hsa005900.51021355
110Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50635756
111Peroxisome_Homo sapiens_hsa041460.50590657
112African trypanosomiasis_Homo sapiens_hsa051430.50092639
113Alcoholism_Homo sapiens_hsa050340.49799591
114Dorso-ventral axis formation_Homo sapiens_hsa043200.49680978
115Pancreatic secretion_Homo sapiens_hsa049720.49281542
116Steroid biosynthesis_Homo sapiens_hsa001000.48719774
117Sulfur relay system_Homo sapiens_hsa041220.48159835
118Mineral absorption_Homo sapiens_hsa049780.47271180
119Glycerolipid metabolism_Homo sapiens_hsa005610.46489507
120Fat digestion and absorption_Homo sapiens_hsa049750.45678877
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.44369417
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43788083
123Autoimmune thyroid disease_Homo sapiens_hsa053200.43371048
124Salmonella infection_Homo sapiens_hsa051320.42914590
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42583690
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41585843
127Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40869669
128Platelet activation_Homo sapiens_hsa046110.40483746
129Inositol phosphate metabolism_Homo sapiens_hsa005620.38992830
130Metabolic pathways_Homo sapiens_hsa011000.38410032
131Sphingolipid metabolism_Homo sapiens_hsa006000.37587099
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.37439023
133Lysine degradation_Homo sapiens_hsa003100.37076947
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36639088
135beta-Alanine metabolism_Homo sapiens_hsa004100.36149804
136Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36091975
137Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35570539
138Purine metabolism_Homo sapiens_hsa002300.35160198
139HIF-1 signaling pathway_Homo sapiens_hsa040660.34960414
140Chemical carcinogenesis_Homo sapiens_hsa052040.34594606
141Allograft rejection_Homo sapiens_hsa053300.34333229
142Non-homologous end-joining_Homo sapiens_hsa034500.34115327
143Cardiac muscle contraction_Homo sapiens_hsa042600.33103048
144Non-small cell lung cancer_Homo sapiens_hsa052230.32387644
145Tuberculosis_Homo sapiens_hsa051520.31685420
146Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30306576
147Propanoate metabolism_Homo sapiens_hsa006400.29879414
148Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29193242
149Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28089109

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »