SPRR1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an envelope protein of keratinocytes. The encoded protein is crosslinked to membrane proteins by transglutaminase, forming an insoluble layer under the plasma membrane. This protein is proline-rich and contains several tandem amino acid repeats. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intermediate filament organization (GO:0045109)8.86043578
2* keratinocyte differentiation (GO:0030216)7.84765153
3* peptide cross-linking (GO:0018149)7.77079599
4lipoxygenase pathway (GO:0019372)7.63951396
5ectoderm development (GO:0007398)7.44733112
6skin morphogenesis (GO:0043589)7.35544227
7* epidermis development (GO:0008544)7.17836211
8multicellular organismal water homeostasis (GO:0050891)7.02392698
9bundle of His cell to Purkinje myocyte communication (GO:0086069)6.76795456
10intermediate filament cytoskeleton organization (GO:0045104)6.36067550
11intermediate filament-based process (GO:0045103)6.15522236
12water homeostasis (GO:0030104)5.84165038
13* epidermal cell differentiation (GO:0009913)5.79594464
14regulation of natural killer cell differentiation (GO:0032823)5.58924724
15negative regulation of interferon-gamma production (GO:0032689)5.46487203
16fatty acid elongation (GO:0030497)4.99566945
17keratinocyte development (GO:0003334)4.97506644
18negative regulation of interleukin-17 production (GO:0032700)4.87741187
19cell-substrate junction assembly (GO:0007044)4.85640722
20sequestering of metal ion (GO:0051238)4.63479256
21keratinocyte proliferation (GO:0043616)4.31827185
22positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)4.29680330
23phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.28956448
24positive regulation of T cell chemotaxis (GO:0010820)4.16236375
25regulation of T cell chemotaxis (GO:0010819)4.16236375
26response to zinc ion (GO:0010043)3.97762394
27skin development (GO:0043588)3.96399230
28phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.95117239
29detection of external biotic stimulus (GO:0098581)3.89296422
30cellular response to interleukin-4 (GO:0071353)3.88556350
31virion attachment to host cell (GO:0019062)3.87770633
32adhesion of symbiont to host cell (GO:0044650)3.87770633
33phosphatidylcholine acyl-chain remodeling (GO:0036151)3.81560279
34chemical homeostasis within a tissue (GO:0048875)3.80000597
35negative regulation of keratinocyte proliferation (GO:0010839)3.76250966
36positive regulation of monocyte chemotaxis (GO:0090026)3.73041153
37fibrinolysis (GO:0042730)3.43486494
38phosphatidylserine metabolic process (GO:0006658)3.42665683
39adhesion of symbiont to host (GO:0044406)3.42219174
40detection of biotic stimulus (GO:0009595)3.29473826
41long-chain fatty acid biosynthetic process (GO:0042759)3.28958177
42response to interleukin-4 (GO:0070670)3.28019131
43atrioventricular valve morphogenesis (GO:0003181)3.26117585
44* epithelium development (GO:0060429)3.26064014
45hair cell differentiation (GO:0035315)3.18684121
46ceramide biosynthetic process (GO:0046513)3.16650070
47* epithelial cell differentiation (GO:0030855)3.08446726
48negative regulation of cardiac muscle tissue growth (GO:0055022)3.06886185
49negative regulation of heart growth (GO:0061117)3.06886185
50ventricular cardiac muscle cell action potential (GO:0086005)3.05419571
51regulation of monocyte chemotaxis (GO:0090025)3.01837803
52positive regulation of granulocyte chemotaxis (GO:0071624)3.00978428
53negative regulation of cell fate specification (GO:0009996)3.00526195
54* keratinization (GO:0031424)21.7209003
55defense response to fungus (GO:0050832)2.96417378
56wound healing (GO:0042060)2.94749158
57regulation of natural killer cell activation (GO:0032814)2.93763049
58phosphatidylinositol acyl-chain remodeling (GO:0036149)2.91352007
59antimicrobial humoral response (GO:0019730)2.91030378
60apical protein localization (GO:0045176)2.87259839
61positive regulation of epidermis development (GO:0045684)2.85746745
62intestinal epithelial cell development (GO:0060576)2.84592626
63polarized epithelial cell differentiation (GO:0030859)2.82736709
64gap junction assembly (GO:0016264)2.82196877
65regulation of interleukin-17 production (GO:0032660)2.80896744
66alditol phosphate metabolic process (GO:0052646)2.78021131
67planar cell polarity pathway involved in neural tube closure (GO:0090179)2.77552467
68long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.77375031
69cytoskeletal anchoring at plasma membrane (GO:0007016)2.74776298
70long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.68581661
71establishment of tissue polarity (GO:0007164)2.68429899
72establishment of planar polarity (GO:0001736)2.68429899
73eyelid development in camera-type eye (GO:0061029)2.68407048
74response to UV-B (GO:0010224)2.67622738
75positive regulation of epidermal cell differentiation (GO:0045606)2.67165819
76regulation of endothelial cell chemotaxis (GO:2001026)2.65002702
77regulation of T cell migration (GO:2000404)2.64904504
78regulation of neuron projection regeneration (GO:0070570)2.63711889
79regulation of axon regeneration (GO:0048679)2.63711889
80regulation of cardioblast differentiation (GO:0051890)2.63094364
81regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.61103556
82regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.60041860
83defense response to Gram-negative bacterium (GO:0050829)2.59071295
84fatty-acyl-CoA biosynthetic process (GO:0046949)2.57820137
85lateral sprouting from an epithelium (GO:0060601)2.55285779
86phosphatidylserine acyl-chain remodeling (GO:0036150)2.54294845
87muscle filament sliding (GO:0030049)2.52600970
88actin-myosin filament sliding (GO:0033275)2.52600970
89cytidine metabolic process (GO:0046087)2.52325692
90cytidine catabolic process (GO:0006216)2.52325692
91cytidine deamination (GO:0009972)2.52325692
92epithelial cell-cell adhesion (GO:0090136)2.52169506
93phospholipid catabolic process (GO:0009395)2.51322717
94negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.49323832
95regulation of lymphocyte chemotaxis (GO:1901623)2.47436092
96positive regulation of keratinocyte differentiation (GO:0045618)2.46198815
97detection of bacterium (GO:0016045)2.45206318
98positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.42821411
99hair follicle morphogenesis (GO:0031069)2.40680734
100regulation of epidermal cell differentiation (GO:0045604)2.40267339
101regulation of epidermis development (GO:0045682)2.38037208
102regulation of heart rate by cardiac conduction (GO:0086091)2.36121663
103cell communication involved in cardiac conduction (GO:0086065)2.35831395
104regulation of cholesterol homeostasis (GO:2000188)2.34929843
105regulation of hydrogen peroxide metabolic process (GO:0010310)2.31772901
106epithelial cell differentiation involved in prostate gland development (GO:0060742)2.31494164
107linoleic acid metabolic process (GO:0043651)2.30925570
108renal absorption (GO:0070293)2.29935319
109one-carbon compound transport (GO:0019755)2.28927829
110cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.27925984
111regulation of protein localization to cell surface (GO:2000008)2.27783202
112regulation of hair cycle (GO:0042634)2.25343237
113hormone catabolic process (GO:0042447)2.23569053
114amyloid precursor protein metabolic process (GO:0042982)2.22740762
115chronic inflammatory response (GO:0002544)2.22603545
116response to phenylpropanoid (GO:0080184)2.22239844
117regulation of ruffle assembly (GO:1900027)2.22003862
118fatty-acyl-CoA metabolic process (GO:0035337)2.21678811
119very long-chain fatty acid metabolic process (GO:0000038)2.21057146
120asymmetric protein localization (GO:0008105)2.20366646
121localization within membrane (GO:0051668)2.20224074
122regulation of hair follicle development (GO:0051797)2.20014745
123plasma membrane repair (GO:0001778)2.18929448
124interleukin-1-mediated signaling pathway (GO:0070498)2.18573771
125positive regulation of protein export from nucleus (GO:0046827)2.17691794
126negative regulation of cytokine-mediated signaling pathway (GO:0001960)2.13757856
127detection of other organism (GO:0098543)2.13523615
128regulation of keratinocyte proliferation (GO:0010837)2.13488833
129membrane raft organization (GO:0031579)2.13222828
130citrulline biosynthetic process (GO:0019240)2.12944729
131complement activation, classical pathway (GO:0006958)2.12355813
132positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.11529206
133surfactant homeostasis (GO:0043129)2.11246995
134positive regulation of cholesterol efflux (GO:0010875)2.11160422
135polyol transport (GO:0015791)2.10470410
136protein localization to endosome (GO:0036010)2.09451380
137regulation of keratinocyte differentiation (GO:0045616)2.08893673
138negative regulation of cell fate commitment (GO:0010454)2.07528627
139response to vitamin D (GO:0033280)2.07128905
140cell junction organization (GO:0034330)2.06119973
141phospholipid efflux (GO:0033700)2.05192465
142actin-mediated cell contraction (GO:0070252)2.04569258
143hair cycle (GO:0042633)17.2353166
144molting cycle (GO:0042303)17.2353166
145hemidesmosome assembly (GO:0031581)13.4164409
146desmosome organization (GO:0002934)12.4249975
147establishment of skin barrier (GO:0061436)12.1778352
148regulation of water loss via skin (GO:0033561)10.7147031

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.63352435
2P63_26484246_Chip-Seq_KERATINOCYTES_Human2.99261282
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.89243349
4ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.34174181
5* SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.16764838
6SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.04410536
7SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.04410536
8TP63_17297297_ChIP-ChIP_HaCaT_Human16.1182174
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.97441270
10ZNF263_19887448_ChIP-Seq_K562_Human1.95266463
11EGR1_19032775_ChIP-ChIP_M12_Human1.92427036
12SOX9_24532713_ChIP-Seq_HFSC_Mouse1.81210554
13TRIM28_21343339_ChIP-Seq_HEK293_Human1.80736525
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.67297351
15ESR1_20079471_ChIP-ChIP_T-47D_Human1.67177808
16RACK7_27058665_Chip-Seq_MCF-7_Human1.55198813
17CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.53707051
18ESR2_21235772_ChIP-Seq_MCF-7_Human1.52713827
19ESR1_21235772_ChIP-Seq_MCF-7_Human1.50484097
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.50059689
21* ATF3_27146783_Chip-Seq_COLON_Human1.49798219
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39557090
23FOXO3_23340844_ChIP-Seq_DLD1_Human1.38380256
24DNAJC2_21179169_ChIP-ChIP_NT2_Human1.32550194
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.31777468
26KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31269416
27CLOCK_20551151_ChIP-Seq_293T_Human1.29987473
28UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29099915
29TP63_22573176_ChIP-Seq_HFKS_Human1.27476098
30LXR_22292898_ChIP-Seq_THP-1_Human1.27026406
31E2F1_20622854_ChIP-Seq_HELA_Human1.26708384
32ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21681567
33KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20707594
34ERG_20517297_ChIP-Seq_VCAP_Human1.18226065
35ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.16876089
36SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16352006
37* TP63_23658742_ChIP-Seq_EP156T_Human1.16295000
38* SOX2_20726797_ChIP-Seq_SW620_Human1.16184496
39TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15869733
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.11797996
41CJUN_26792858_Chip-Seq_BT549_Human1.11400119
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11238092
43P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.11206993
44* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.10477756
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08162623
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08020688
47* CTCF_27219007_Chip-Seq_Bcells_Human1.07930151
48GATA6_21074721_ChIP-Seq_CACO-2_Human1.07477844
49UBF1/2_26484160_Chip-Seq_HMECs_Human1.07351327
50RXR_22108803_ChIP-Seq_LS180_Human1.07270922
51BCOR_27268052_Chip-Seq_Bcells_Human1.05234089
52SA1_27219007_Chip-Seq_ERYTHROID_Human1.04199321
53VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03829607
54GATA3_24758297_ChIP-Seq_MCF-7_Human1.03684531
55SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02845986
56TCF4_18268006_ChIP-ChIP_LS174T_Human1.02440044
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01873319
58ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01669509
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01614500
60* CTCF_20526341_ChIP-Seq_ESCs_Human1.01246198
61KLF5_25053715_ChIP-Seq_YYC3_Human0.99528548
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98393319
63AHR_22903824_ChIP-Seq_MCF-7_Human0.96374529
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95994492
65P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95813775
66* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95610428
67GATA4_25053715_ChIP-Seq_YYC3_Human0.94988374
68ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94058275
69RUNX1_27514584_Chip-Seq_MCF-7_Human0.92439927
70RBPJ_21746931_ChIP-Seq_IB4_Human0.92432966
71KDM2B_26808549_Chip-Seq_DND41_Human0.92212056
72FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.91005897
73SUZ12_27294783_Chip-Seq_ESCs_Mouse0.90628187
74FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88954309
75CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88776338
76* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88766727
77YY1_22570637_ChIP-Seq_MALME-3M_Human0.88589471
78P68_20966046_ChIP-Seq_HELA_Human0.87713324
79SPI1_20517297_ChIP-Seq_HL60_Human0.85467131
80GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.84047111
81TP53_20018659_ChIP-ChIP_R1E_Mouse0.82764057
82CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.80549459
83SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.80345253
84KDM2B_26808549_Chip-Seq_SUP-B15_Human0.80222439
85HTT_18923047_ChIP-ChIP_STHdh_Human0.79916999
86* BCL6_27268052_Chip-Seq_Bcells_Human0.79711728
87* NANOG_20526341_ChIP-Seq_ESCs_Human0.79218264
88KDM2B_26808549_Chip-Seq_K562_Human0.79015715
89TAF2_19829295_ChIP-Seq_ESCs_Human0.78623595
90* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.78604826
91KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.78400213
92SMC4_20622854_ChIP-Seq_HELA_Human0.78237451
93TP53_18474530_ChIP-ChIP_U2OS_Human0.78188900
94TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.77844997
95ERG_21242973_ChIP-ChIP_JURKAT_Human0.77701391
96ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.77672460
97ZNF217_24962896_ChIP-Seq_MCF-7_Human0.77200548
98RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76813165
99BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.74859659
100AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74611329
101HNFA_21074721_ChIP-Seq_CACO-2_Human0.74334086
102AR_21572438_ChIP-Seq_LNCaP_Human0.73426673
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.73081501
104SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.72935701
105CEBPB_22108803_ChIP-Seq_LS180_Human0.72653048
106PPARA_22158963_ChIP-Seq_LIVER_Mouse0.72476542
107GATA2_21666600_ChIP-Seq_HMVEC_Human0.70984170
108P53_21459846_ChIP-Seq_SAOS-2_Human0.69419710
109GATA6_25053715_ChIP-Seq_YYC3_Human0.68750517
110CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.68743090
111FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.68596283
112KDM2B_26808549_Chip-Seq_JURKAT_Human0.68474595
113TBX20_22328084_ChIP-Seq_HEART_Mouse0.68246659
114TBX20_22080862_ChIP-Seq_HEART_Mouse0.68246659
115MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.67927282
116JARID2_20075857_ChIP-Seq_MESCs_Mouse0.67711249
117EZH2_27294783_Chip-Seq_ESCs_Mouse0.67637066
118RAC3_21632823_ChIP-Seq_H3396_Human0.66514136
119ARNT_22903824_ChIP-Seq_MCF-7_Human0.65454802
120* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.64678415
121MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.64377515
122GATA2_19941826_ChIP-Seq_K562_Human0.63654609
123CDX2_20551321_ChIP-Seq_CACO-2_Human0.60903073
124FOXA1_25552417_ChIP-Seq_VCAP_Human0.60617371
125TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.60337372
126EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.59899453
127TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.59214553
128SA1_27219007_Chip-Seq_Bcells_Human0.59205798
129PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.58004901

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.92616414
2MP0002796_impaired_skin_barrier7.74810068
3MP0005275_abnormal_skin_tensile5.93722830
4MP0005501_abnormal_skin_physiology4.98783355
5MP0000467_abnormal_esophagus_morphology4.01464580
6MP0010234_abnormal_vibrissa_follicle3.58548119
7MP0003705_abnormal_hypodermis_morpholog3.47825185
8MP0000383_abnormal_hair_follicle3.37484276
9MP0001216_abnormal_epidermal_layer3.30117111
10MP0003453_abnormal_keratinocyte_physiol3.25340977
11MP0004381_abnormal_hair_follicle3.11449845
12MP0002060_abnormal_skin_morphology3.06446382
13MP0010771_integument_phenotype2.97913395
14MP0010678_abnormal_skin_adnexa2.96321245
15MP0000647_abnormal_sebaceous_gland2.60102447
16MP0004947_skin_inflammation2.53071037
17MP0000762_abnormal_tongue_morphology2.50566842
18MP0003878_abnormal_ear_physiology2.48634862
19MP0005377_hearing/vestibular/ear_phenot2.48634862
20MP0000377_abnormal_hair_follicle2.44273149
21MP0002254_reproductive_system_inflammat2.42901590
22MP0002098_abnormal_vibrissa_morphology2.27358127
23MP0005409_darkened_coat_color2.22497712
24MP0003941_abnormal_skin_development2.15944115
25MP0000427_abnormal_hair_cycle2.15320094
26MP0003191_abnormal_cellular_cholesterol2.14372577
27MP0003566_abnormal_cell_adhesion2.12801161
28MP0002234_abnormal_pharynx_morphology1.83253954
29MP0009931_abnormal_skin_appearance1.69852202
30MP0008438_abnormal_cutaneous_collagen1.66890845
31MP0004185_abnormal_adipocyte_glucose1.51072272
32MP0001191_abnormal_skin_condition1.45303740
33MP0001243_abnormal_dermal_layer1.44629741
34MP0009053_abnormal_anal_canal1.43633298
35MP0004043_abnormal_pH_regulation1.42998541
36MP0000465_gastrointestinal_hemorrhage1.38933258
37MP0000367_abnormal_coat/_hair1.38254096
38MP0005023_abnormal_wound_healing1.33912736
39MP0005451_abnormal_body_composition1.30121962
40MP0001849_ear_inflammation1.27420846
41MP0001851_eye_inflammation1.25784266
42MP0008789_abnormal_olfactory_epithelium0.83572635
43MP0010352_gastrointestinal_tract_polyps0.82782047
44MP0001188_hyperpigmentation0.81669502
45MP0002282_abnormal_trachea_morphology0.74843919
46MP0003303_peritoneal_inflammation0.66855997
47MP0003950_abnormal_plasma_membrane0.66370258
48MP0003436_decreased_susceptibility_to0.64700266
49MP0003755_abnormal_palate_morphology0.64535057
50MP0005394_taste/olfaction_phenotype0.64295631
51MP0005499_abnormal_olfactory_system0.64295631
52MP0004272_abnormal_basement_membrane0.64278626
53MP0001340_abnormal_eyelid_morphology0.63483383
54MP0001784_abnormal_fluid_regulation0.61434573
55MP0000751_myopathy0.57419965
56MP0001346_abnormal_lacrimal_gland0.54313453
57MP0009379_abnormal_foot_pigmentation0.53233431
58MP0000749_muscle_degeneration0.52879362
59MP0004885_abnormal_endolymph0.50941613
60MP0005666_abnormal_adipose_tissue0.50345349
61MP0003315_abnormal_perineum_morphology0.50046890
62MP0008004_abnormal_stomach_pH0.47720276
63MP0004264_abnormal_extraembryonic_tissu0.47110060
64MP0002877_abnormal_melanocyte_morpholog0.46585820
65MP0004858_abnormal_nervous_system0.46257161
66MP0009780_abnormal_chondrocyte_physiolo0.45873371
67MP0004782_abnormal_surfactant_physiolog0.44991237
68MP0000678_abnormal_parathyroid_gland0.44957775
69MP0002138_abnormal_hepatobiliary_system0.44684130
70MP0005503_abnormal_tendon_morphology0.43593780
71MP0000538_abnormal_urinary_bladder0.42538603
72MP0003724_increased_susceptibility_to0.42282560
73MP0006054_spinal_hemorrhage0.41288140
74MP0003300_gastrointestinal_ulcer0.40611081
75MP0003011_delayed_dark_adaptation0.39262541
76MP0002837_dystrophic_cardiac_calcinosis0.38822684
77MP0000627_abnormal_mammary_gland0.38813772
78MP0001533_abnormal_skeleton_physiology0.38099944
79MP0005375_adipose_tissue_phenotype0.37932793
80MP0003329_amyloid_beta_deposits0.36243950
81MP0000750_abnormal_muscle_regeneration0.35589926
82MP0010368_abnormal_lymphatic_system0.35117094
83MP0009333_abnormal_splenocyte_physiolog0.34960663
84MP0001485_abnormal_pinna_reflex0.34537152
85MP0000747_muscle_weakness0.33939078
86MP0002177_abnormal_outer_ear0.33743923
87MP0000733_abnormal_muscle_development0.32613351
88MP0003448_altered_tumor_morphology0.31487613
89MP0008260_abnormal_autophagy0.30875496
90MP0002111_abnormal_tail_morphology0.30678192
91MP0005076_abnormal_cell_differentiation0.29977506
92MP0005193_abnormal_anterior_eye0.29971756
93MP0000003_abnormal_adipose_tissue0.29550593
94MP0003075_altered_response_to0.28588361
95MP0000343_altered_response_to0.28280091
96MP0004087_abnormal_muscle_fiber0.27948123
97MP0002095_abnormal_skin_pigmentation0.27688247
98MP0001958_emphysema0.26784111
99MP0003828_pulmonary_edema0.26421504
100MP0010030_abnormal_orbit_morphology0.26313453
101MP0000470_abnormal_stomach_morphology0.26082294
102MP0003385_abnormal_body_wall0.25865191
103MP0003638_abnormal_response/metabolism_0.25771306
104MP0005388_respiratory_system_phenotype0.25228379
105MP0002133_abnormal_respiratory_system0.25228379
106MP0000604_amyloidosis0.25159964
107MP0008569_lethality_at_weaning0.23473903
108MP0001765_abnormal_ion_homeostasis0.21726947
109MP0000759_abnormal_skeletal_muscle0.21684617
110MP0000566_synostosis0.21334262
111MP0002233_abnormal_nose_morphology0.21176185
112MP0009840_abnormal_foam_cell0.19843755
113MP0002933_joint_inflammation0.18542856
114MP0001879_abnormal_lymphatic_vessel0.18333656
115MP0002006_tumorigenesis0.18054196
116MP0000685_abnormal_immune_system0.17126415
117MP0003763_abnormal_thymus_physiology0.16059027
118MP0004197_abnormal_fetal_growth/weight/0.15967332
119MP0005330_cardiomyopathy0.15553198
120MP0002896_abnormal_bone_mineralization0.15428556
121MP0005390_skeleton_phenotype0.15362196
122MP0001186_pigmentation_phenotype0.15055277
123MP0005075_abnormal_melanosome_morpholog0.13525575
124MP0001502_abnormal_circadian_rhythm0.13047675
125MP0000858_altered_metastatic_potential0.11441203
126MP0003045_fibrosis0.11108117
127MP0009115_abnormal_fat_cell0.10995281
128MP0002166_altered_tumor_susceptibility0.07224174
129MP0002075_abnormal_coat/hair_pigmentati0.05983683
130MP0001177_atelectasis0.05497012

Predicted human phenotypes

RankGene SetZ-score
1Plantar hyperkeratosis (HP:0007556)7.75862921
2Palmoplantar hyperkeratosis (HP:0000972)7.69011050
3Oral leukoplakia (HP:0002745)7.40547873
4Palmar hyperkeratosis (HP:0010765)7.26669564
5Alopecia of scalp (HP:0002293)7.13733138
6Onycholysis (HP:0001806)6.96082554
7Increased IgE level (HP:0003212)6.81193170
8Hypotrichosis (HP:0001006)6.31404348
9Follicular hyperkeratosis (HP:0007502)6.26969380
10Milia (HP:0001056)6.21684351
11Fragile nails (HP:0001808)6.18962900
12Woolly hair (HP:0002224)5.37946265
13Abnormal blistering of the skin (HP:0008066)4.95564589
14Abnormality of secondary sexual hair (HP:0009888)4.90621495
15Abnormality of the axillary hair (HP:0100134)4.90621495
16Right ventricular cardiomyopathy (HP:0011663)4.75545137
17Nail dystrophy (HP:0008404)4.62894639
18Pili torti (HP:0003777)4.58180022
19Pustule (HP:0200039)4.22363007
20Erythroderma (HP:0001019)4.20432741
21Erythema (HP:0010783)4.08869170
22Conjunctival hamartoma (HP:0100780)4.06412336
23Laryngomalacia (HP:0001601)3.85354587
24Ridged nail (HP:0001807)3.82667105
25Atrophic scars (HP:0001075)3.52527374
26Congenital ichthyosiform erythroderma (HP:0007431)3.50140011
27Sparse scalp hair (HP:0002209)3.38256731
28Palmoplantar keratoderma (HP:0000982)3.37406590
29Absent hair (HP:0002298)3.31370142
30Corneal dystrophy (HP:0001131)3.25133502
31Amniotic constriction ring (HP:0009775)3.19280500
32Abnormality of placental membranes (HP:0011409)3.19280500
33Fatigable weakness (HP:0003473)3.09435819
34Abnormality of the neuromuscular junction (HP:0003398)3.09435819
35Furrowed tongue (HP:0000221)3.02264950
36Anonychia (HP:0001798)3.00984890
37Abnormality of the salivary glands (HP:0010286)2.97204119
38Gangrene (HP:0100758)2.90857580
39Abnormal hair laboratory examination (HP:0003328)2.88596899
40Ectropion (HP:0000656)2.87669015
41Hyperhidrosis (HP:0000975)2.79888199
42Hypohidrosis (HP:0000966)2.70337354
43Corneal erosion (HP:0200020)2.63253338
44Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.62442160
45Type 1 muscle fiber predominance (HP:0003803)2.57314829
46Hamartoma of the eye (HP:0010568)2.54607306
47Dehydration (HP:0001944)2.53805709
48Muscle fiber inclusion bodies (HP:0100299)2.52276178
49Round ear (HP:0100830)2.48915741
50Verrucae (HP:0200043)2.43130354
51Papilloma (HP:0012740)2.43130354
52Ventricular tachycardia (HP:0004756)2.42814917
53Nemaline bodies (HP:0003798)2.42019085
54Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.40908040
55Lip pit (HP:0100267)2.38489550
56Sparse eyelashes (HP:0000653)2.35550342
57Hyporeflexia of lower limbs (HP:0002600)2.33608376
58Increased connective tissue (HP:0009025)2.33304188
59Advanced eruption of teeth (HP:0006288)2.30551934
60Carious teeth (HP:0000670)2.25122144
61Distal arthrogryposis (HP:0005684)2.22833749
62Multifactorial inheritance (HP:0001426)2.21691778
63Fragile skin (HP:0001030)2.20639357
64Muscle fiber splitting (HP:0003555)2.17091195
65Hypergammaglobulinemia (HP:0010702)2.12867284
66Natal tooth (HP:0000695)2.11059779
67Curly hair (HP:0002212)2.08651537
68Abnormality of the fingernails (HP:0001231)2.06825129
69Hypoplastic labia majora (HP:0000059)2.05267548
70Neonatal onset (HP:0003623)2.04977570
71Pruritus (HP:0000989)2.04399305
72Aplasia cutis congenita (HP:0001057)2.00414471
73Abnormality of nail color (HP:0100643)13.9365149
74Thick nail (HP:0001805)10.0012708
75Abnormality of small intestinal villus morphology (HP:0011472)1.99552572
76Villous atrophy (HP:0011473)1.99552572
77Myopathic facies (HP:0002058)1.97649664
78Parakeratosis (HP:0001036)1.96002501
79Ulnar deviation of the wrist (HP:0003049)1.94658276
80Paralysis (HP:0003470)1.94320803
81Calcaneovalgus deformity (HP:0001848)1.87311120
82Lack of skin elasticity (HP:0100679)1.86501231
83Abnormality of the labia majora (HP:0012881)1.86052449
84Fine hair (HP:0002213)1.80828545
85Skin ulcer (HP:0200042)1.78857650
86Neck muscle weakness (HP:0000467)1.77990711
87Axonal loss (HP:0003447)1.76672101
88Achilles tendon contracture (HP:0001771)1.74835523
89Premature rupture of membranes (HP:0001788)1.74594078
90Absent eyelashes (HP:0000561)1.73193864
91Sudden death (HP:0001699)1.72262982
92Blepharitis (HP:0000498)1.69471911
93Dry skin (HP:0000958)1.69410051
94Eczematoid dermatitis (HP:0000976)1.68571230
95Popliteal pterygium (HP:0009756)1.67659030
96Sepsis (HP:0100806)1.66957326
97Acanthosis nigricans (HP:0000956)1.66441745
98Oligodontia (HP:0000677)1.64287400
99Deformed tarsal bones (HP:0008119)1.62767223
100Abnormality of the Achilles tendon (HP:0005109)1.62362547
101Recurrent bacterial skin infections (HP:0005406)1.58567724
102Selective tooth agenesis (HP:0001592)1.58134332
103Exercise-induced myalgia (HP:0003738)1.57532254
104Distal lower limb muscle weakness (HP:0009053)1.55740101
105Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.55570273
106Melanocytic nevus (HP:0000995)1.52723478
107Brittle hair (HP:0002299)1.52291987
108Hypoplastic toenails (HP:0001800)1.50183670
109Dry hair (HP:0011359)1.48759884
110Abnormality of hair growth rate (HP:0011363)1.48375494
111Slow-growing hair (HP:0002217)1.48375494
112Keratoconjunctivitis sicca (HP:0001097)1.46825995
113Absent phalangeal crease (HP:0006109)1.45901066
114Hyperactive renin-angiotensin system (HP:0000841)1.45881191
115Abnormality of skeletal muscle fiber size (HP:0012084)1.43938530
116Split foot (HP:0001839)1.43088527
117Exercise-induced muscle cramps (HP:0003710)1.41888161
118Distal lower limb amyotrophy (HP:0008944)1.41309753
119Preauricular skin tag (HP:0000384)1.40915078
120Protrusio acetabuli (HP:0003179)1.40298162
121Peritonitis (HP:0002586)1.39412482
122Spinal rigidity (HP:0003306)1.38520644
123Frequent falls (HP:0002359)1.38156818
124Recurrent corneal erosions (HP:0000495)1.37645322
125Segmental peripheral demyelination/remyelination (HP:0003481)1.36200863
126Ventricular fibrillation (HP:0001663)1.35474359
127Labial hypoplasia (HP:0000066)1.35323978
128Scapular winging (HP:0003691)1.35045532
129Xerostomia (HP:0000217)1.34492961
130Slender build (HP:0001533)1.30901445
131Urticaria (HP:0001025)1.30526155
132Keratoconjunctivitis (HP:0001096)1.29671379
133Autoamputation (HP:0001218)1.29478737
134Esophageal atresia (HP:0002032)1.29446120
135Hyperkalemia (HP:0002153)1.26317302
136Hypoplastic female external genitalia (HP:0012815)1.23135968

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.35221113
2FER4.43294757
3TRIB33.53693789
4PIK3CG3.25335374
5MST1R2.95503014
6MAP3K32.76266773
7EPHB12.69775098
8SGK4942.69157252
9SGK2232.69157252
10MAPKAPK32.61784422
11NME12.50963296
12TTN2.37473965
13EPHA22.22933485
14BLK2.06445778
15TAOK12.04419492
16RPS6KA41.92769187
17MAP3K111.89058308
18MAP3K61.88773649
19RIPK11.85616972
20EPHA31.84616351
21TGFBR21.80259897
22PKN21.78651423
23MAP3K21.69468203
24EPHB21.69277838
25WNK11.65369216
26FGFR41.60360409
27MAP3K91.57453902
28GRK61.55837343
29MAP2K61.38660036
30FGFR11.38225977
31MAP2K31.31904485
32MAP3K11.31400460
33LATS21.30128293
34RPS6KB21.28154696
35PTK61.25592893
36IRAK11.24998975
37TYK21.24672187
38LATS11.22250823
39TESK11.18525646
40MET1.15614507
41OBSCN1.12335389
42CDK121.09005533
43FGFR31.07453378
44LRRK21.06125192
45CAMK1D1.05272359
46LIMK11.05043921
47DDR21.04790230
48PDGFRA1.00514815
49FGR1.00365890
50SGK31.00206720
51PTK20.98065022
52MARK20.95992105
53BMX0.94211892
54PIM20.90206373
55MST40.88609801
56MAPK70.88485538
57SGK20.87668781
58STK240.87635646
59MAP3K120.87155077
60MAP2K40.86805947
61TRPM70.86351590
62EEF2K0.85232204
63CAMK1G0.82049275
64FES0.80824379
65MAP2K10.80546486
66PDGFRB0.79585361
67MAPKAPK20.79391165
68IKBKB0.79268691
69STK30.77684759
70DMPK0.77423836
71KSR20.77083315
72STK380.76614618
73ILK0.76029494
74CDK60.75285643
75CSK0.74205300
76TIE10.72581565
77FLT30.71418219
78PRKD20.68961451
79NTRK10.68087380
80SGK10.65281176
81PHKG10.63776370
82PHKG20.63776370
83SIK30.62932163
84PAK20.62703523
85NEK10.59778674
86TBK10.59015037
87ERBB30.57647735
88IKBKE0.57482257
89CDC42BPA0.57258877
90STK38L0.56431337
91MAP3K70.56056530
92ALK0.55252903
93JAK10.55079270
94IRAK30.52801716
95RET0.52404896
96RPS6KB10.52211373
97IRAK20.51700001
98PRKD10.49366408
99BCR0.49251750
100HCK0.49091092
101JAK20.47569243
102ADRBK10.47244548
103MTOR0.46829410
104ROCK20.46253094
105MAPK120.45246281
106ABL20.44136046
107STK100.43572165
108RPS6KA10.43445894
109HIPK20.41568746
110MAPK40.40870158
111NTRK20.40581227
112ZAP700.39482463
113MAP3K130.38792752
114NLK0.38635541
115IRAK40.38211903
116JAK30.37404784
117PRPF4B0.34778833
118MAP3K50.34515952
119GSK3A0.33307995
120ARAF0.33204559
121PRKAA20.32886705
122FYN0.32852422
123FGFR20.32476332
124MAP3K80.32033857
125MOS0.30636048
126SIK10.30535949
127TGFBR10.30485058
128PBK0.29461182
129SRC0.29257623
130STK390.29159811
131ERBB20.28903964
132PAK40.28004267
133DYRK1B0.27305548
134TYRO30.25797463
135KIT0.24263321
136MATK0.23823403
137EGFR0.22252184
138ROCK10.22180669
139PRKCE0.19991805
140AKT20.19883887
141TAOK30.19810300
142PTK2B0.17398216
143MAPKAPK50.16933447

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.37509120
2Fatty acid elongation_Homo sapiens_hsa000622.82311527
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.79845261
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.54178901
5Linoleic acid metabolism_Homo sapiens_hsa005912.54088427
6ECM-receptor interaction_Homo sapiens_hsa045122.35223600
7Staphylococcus aureus infection_Homo sapiens_hsa051502.23984134
8Caffeine metabolism_Homo sapiens_hsa002322.02777003
9VEGF signaling pathway_Homo sapiens_hsa043701.83536341
10Ovarian steroidogenesis_Homo sapiens_hsa049131.81514376
11Circadian rhythm_Homo sapiens_hsa047101.79476214
12Amoebiasis_Homo sapiens_hsa051461.77381822
13Pertussis_Homo sapiens_hsa051331.59835838
14Arachidonic acid metabolism_Homo sapiens_hsa005901.57266067
15Ether lipid metabolism_Homo sapiens_hsa005651.56914083
16Proteoglycans in cancer_Homo sapiens_hsa052051.55576664
17Fat digestion and absorption_Homo sapiens_hsa049751.50686103
18Focal adhesion_Homo sapiens_hsa045101.43760761
19GnRH signaling pathway_Homo sapiens_hsa049121.43604408
20Toxoplasmosis_Homo sapiens_hsa051451.43150228
21Phenylalanine metabolism_Homo sapiens_hsa003601.42523480
22Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.42090428
23Serotonergic synapse_Homo sapiens_hsa047261.38014077
24Acute myeloid leukemia_Homo sapiens_hsa052211.35368950
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32766267
26Glycerophospholipid metabolism_Homo sapiens_hsa005641.29821589
27Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.29815267
28Adherens junction_Homo sapiens_hsa045201.28075724
29Dilated cardiomyopathy_Homo sapiens_hsa054141.27544184
30Bladder cancer_Homo sapiens_hsa052191.27194441
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.23457391
32Choline metabolism in cancer_Homo sapiens_hsa052311.22693197
33Phototransduction_Homo sapiens_hsa047441.18767489
34Malaria_Homo sapiens_hsa051441.15009662
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10393424
36PPAR signaling pathway_Homo sapiens_hsa033201.08919987
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08913555
38Nitrogen metabolism_Homo sapiens_hsa009101.08740594
39Histidine metabolism_Homo sapiens_hsa003401.05128166
40Tight junction_Homo sapiens_hsa045301.03790753
41Dorso-ventral axis formation_Homo sapiens_hsa043201.03528444
42Platelet activation_Homo sapiens_hsa046111.03405028
43Axon guidance_Homo sapiens_hsa043601.03067190
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02679848
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01642896
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99936671
47Salmonella infection_Homo sapiens_hsa051320.98350617
48Glioma_Homo sapiens_hsa052140.97514809
49Long-term depression_Homo sapiens_hsa047300.97342195
50Sphingolipid metabolism_Homo sapiens_hsa006000.90844029
51Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88535453
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87182500
53Shigellosis_Homo sapiens_hsa051310.86818019
54Complement and coagulation cascades_Homo sapiens_hsa046100.85907841
55Insulin resistance_Homo sapiens_hsa049310.85645355
56Tuberculosis_Homo sapiens_hsa051520.84343674
57Sphingolipid signaling pathway_Homo sapiens_hsa040710.84168159
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.83928419
59Renal cell carcinoma_Homo sapiens_hsa052110.80741466
60TNF signaling pathway_Homo sapiens_hsa046680.79560036
61Leishmaniasis_Homo sapiens_hsa051400.77408366
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77276843
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.77044990
64Estrogen signaling pathway_Homo sapiens_hsa049150.76657463
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.76572412
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75552413
67MicroRNAs in cancer_Homo sapiens_hsa052060.75314718
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74874130
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.73577614
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73218032
71Endocytosis_Homo sapiens_hsa041440.72960522
72Osteoclast differentiation_Homo sapiens_hsa043800.72259032
73Thyroid cancer_Homo sapiens_hsa052160.72037071
74Small cell lung cancer_Homo sapiens_hsa052220.71832320
75Pancreatic secretion_Homo sapiens_hsa049720.71460491
76Steroid biosynthesis_Homo sapiens_hsa001000.71437264
77Renin secretion_Homo sapiens_hsa049240.71071232
78Melanogenesis_Homo sapiens_hsa049160.70964856
79Notch signaling pathway_Homo sapiens_hsa043300.70120283
80Ras signaling pathway_Homo sapiens_hsa040140.69445473
81Gastric acid secretion_Homo sapiens_hsa049710.68740116
82Prion diseases_Homo sapiens_hsa050200.66518367
83Oxytocin signaling pathway_Homo sapiens_hsa049210.65734493
84Hippo signaling pathway_Homo sapiens_hsa043900.65263823
85Hepatitis C_Homo sapiens_hsa051600.65230332
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.65152232
87Basal cell carcinoma_Homo sapiens_hsa052170.64902353
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64764290
89Influenza A_Homo sapiens_hsa051640.61010788
90Rap1 signaling pathway_Homo sapiens_hsa040150.60053658
91Gap junction_Homo sapiens_hsa045400.59174405
92Phagosome_Homo sapiens_hsa041450.58940361
93Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58333373
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.57010532
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55606477
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.55193031
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53321950
98MAPK signaling pathway_Homo sapiens_hsa040100.52958545
99Long-term potentiation_Homo sapiens_hsa047200.52675893
100HIF-1 signaling pathway_Homo sapiens_hsa040660.52241314
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51726874
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49871504
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49529091
104Apoptosis_Homo sapiens_hsa042100.49470336
105Tyrosine metabolism_Homo sapiens_hsa003500.49399662
106ErbB signaling pathway_Homo sapiens_hsa040120.48838514
107Legionellosis_Homo sapiens_hsa051340.48731558
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.47847561
109Protein digestion and absorption_Homo sapiens_hsa049740.46424773
110p53 signaling pathway_Homo sapiens_hsa041150.45533755
111Arginine biosynthesis_Homo sapiens_hsa002200.45258536
112Pancreatic cancer_Homo sapiens_hsa052120.44752694
113Chemokine signaling pathway_Homo sapiens_hsa040620.44226116
114Insulin signaling pathway_Homo sapiens_hsa049100.44214676
115Salivary secretion_Homo sapiens_hsa049700.43469461
116Glutamatergic synapse_Homo sapiens_hsa047240.42724176
117Inositol phosphate metabolism_Homo sapiens_hsa005620.39562871
118Collecting duct acid secretion_Homo sapiens_hsa049660.37732751
119Retinol metabolism_Homo sapiens_hsa008300.37244590
120Pathways in cancer_Homo sapiens_hsa052000.35641640
121Chronic myeloid leukemia_Homo sapiens_hsa052200.35597986
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35588840
123Glucagon signaling pathway_Homo sapiens_hsa049220.34769379
124Renin-angiotensin system_Homo sapiens_hsa046140.33575712
125Galactose metabolism_Homo sapiens_hsa000520.31287265
126ABC transporters_Homo sapiens_hsa020100.29372879

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