ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	long-chain fatty acid biosynthetic process (GO:0042759)	9.01085241
2	* epidermis development (GO:0008544)	8.66494147
3	multicellular organismal water homeostasis (GO:0050891)	8.45620461
4	lipoxygenase pathway (GO:0019372)	7.94736627
5	detection of bacterium (GO:0016045)	7.67233580
6	water homeostasis (GO:0030104)	7.06053852
7	linoleic acid metabolic process (GO:0043651)	7.02427551
8	detection of other organism (GO:0098543)	7.00455264
9	molting cycle (GO:0042303)	6.97385863
10	hair cycle (GO:0042633)	6.97385863
11	keratinocyte proliferation (GO:0043616)	6.91419797
12	bundle of His cell to Purkinje myocyte communication (GO:0086069)	6.49252280
13	regulation of natural killer cell differentiation (GO:0032823)	5.89017028
14	negative regulation of interferon-gamma production (GO:0032689)	5.79223465
15	negative regulation of interleukin-17 production (GO:0032700)	5.63709985
16	positive regulation of monocyte chemotaxis (GO:0090026)	5.58578552
17	sequestering of metal ion (GO:0051238)	5.56799879
18	phosphatidylserine acyl-chain remodeling (GO:0036150)	5.54933240
19	phosphatidylinositol acyl-chain remodeling (GO:0036149)	5.40813307
20	ectoderm development (GO:0007398)	5.25772243
21	skin morphogenesis (GO:0043589)	5.00176704
22	gap junction assembly (GO:0016264)	4.94758102
23	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	4.57522981
24	intermediate filament cytoskeleton organization (GO:0045104)	4.54701765
25	positive regulation of T cell chemotaxis (GO:0010820)	4.51555457
26	regulation of T cell chemotaxis (GO:0010819)	4.51555457
27	establishment of tissue polarity (GO:0007164)	4.49977783
28	establishment of planar polarity (GO:0001736)	4.49977783
29	intermediate filament-based process (GO:0045103)	4.40126065
30	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	4.29582738
31	intermediate filament organization (GO:0045109)	4.20051444
32	regulation of monocyte chemotaxis (GO:0090025)	4.09571858
33	detection of external biotic stimulus (GO:0098581)	4.06038762
34	* epithelium development (GO:0060429)	4.01761569
35	phosphatidylcholine acyl-chain remodeling (GO:0036151)	3.99669106
36	keratinocyte development (GO:0003334)	3.86217470
37	eyelid development in camera-type eye (GO:0061029)	3.85931912
38	hair cell differentiation (GO:0035315)	3.81601450
39	apical protein localization (GO:0045176)	3.81322611
40	hemidesmosome assembly (GO:0031581)	3.61290728
41	* epithelial cell differentiation (GO:0030855)	3.54762696
42	planar cell polarity pathway involved in neural tube closure (GO:0090179)	3.48203272
43	defense response to fungus (GO:0050832)	3.47229754
44	phosphatidylserine metabolic process (GO:0006658)	3.46788384
45	detection of biotic stimulus (GO:0009595)	3.43756573
46	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	3.41932934
47	positive regulation of epidermis development (GO:0045684)	3.41127645
48	antimicrobial humoral response (GO:0019730)	3.39579260
49	transepithelial transport (GO:0070633)	3.37601583
50	positive regulation of granulocyte chemotaxis (GO:0071624)	3.34676545
51	regulation of interleukin-17 production (GO:0032660)	3.27088522
52	regulation of T cell migration (GO:2000404)	3.24110685
53	regulation of natural killer cell activation (GO:0032814)	3.15137783
54	surfactant homeostasis (GO:0043129)	3.14626436
55	hair follicle morphogenesis (GO:0031069)	3.10362575
56	ceramide biosynthetic process (GO:0046513)	3.08725857
57	negative regulation of bone mineralization (GO:0030502)	3.06628234
58	* keratinization (GO:0031424)	27.0648354
59	negative regulation of keratinocyte proliferation (GO:0010839)	2.99146393
60	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	2.89209667
61	positive regulation of epidermal cell differentiation (GO:0045606)	2.88176942
62	localization within membrane (GO:0051668)	2.86533687
63	alditol phosphate metabolic process (GO:0052646)	2.83488579
64	asymmetric protein localization (GO:0008105)	2.81495390
65	defense response to Gram-negative bacterium (GO:0050829)	2.79358836
66	membrane raft organization (GO:0031579)	2.78426423
67	negative regulation of cytokine-mediated signaling pathway (GO:0001960)	2.74907236
68	regulation of lymphocyte chemotaxis (GO:1901623)	2.73728585
69	negative regulation of biomineral tissue development (GO:0070168)	2.72741467
70	regulation of neuron projection regeneration (GO:0070570)	2.72396326
71	regulation of axon regeneration (GO:0048679)	2.72396326
72	intestinal epithelial cell development (GO:0060576)	2.71372259
73	negative regulation of response to cytokine stimulus (GO:0060761)	2.71217212
74	phospholipid catabolic process (GO:0009395)	2.66859077
75	ventricular cardiac muscle cell action potential (GO:0086005)	2.66756129
76	chemical homeostasis within a tissue (GO:0048875)	2.62546327
77	response to phenylpropanoid (GO:0080184)	2.61048419
78	regulation of cholesterol homeostasis (GO:2000188)	2.57813484
79	negative regulation of homotypic cell-cell adhesion (GO:0034111)	2.57248309
80	response to UV-B (GO:0010224)	2.56798694
81	positive regulation of p38MAPK cascade (GO:1900745)	2.50233954
82	complement activation, classical pathway (GO:0006958)	2.48055405
83	regulation of epidermis development (GO:0045682)	2.43834024
84	negative regulation of interleukin-6 production (GO:0032715)	2.41396111
85	wound healing (GO:0042060)	2.40869891
86	regulation of ruffle assembly (GO:1900027)	2.40571944
87	positive regulation of T cell migration (GO:2000406)	2.36644200
88	response to fungus (GO:0009620)	2.31244022
89	regulation of keratinocyte differentiation (GO:0045616)	2.31061324
90	regulation of lymphocyte migration (GO:2000401)	2.28551399
91	leukocyte aggregation (GO:0070486)	2.27677051
92	polarized epithelial cell differentiation (GO:0030859)	2.24134556
93	regulation of keratinocyte proliferation (GO:0010837)	2.22710751
94	atrioventricular valve morphogenesis (GO:0003181)	2.21909073
95	* keratinocyte differentiation (GO:0030216)	15.5866562
96	peptide cross-linking (GO:0018149)	15.0268067
97	establishment of skin barrier (GO:0061436)	14.4718590
98	regulation of water loss via skin (GO:0033561)	12.5049390
99	* epidermal cell differentiation (GO:0009913)	12.1716606
100	desmosome organization (GO:0002934)	10.2986734

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	5.45212449
2	P63_26484246_Chip-Seq_KERATINOCYTES_Human	3.85851053
3	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	3.78864056
4	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.12131186
5	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.88704086
6	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.81808656
7	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.62828159
8	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	2.53136361
9	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	2.53136361
10	HIF1A_21447827_ChIP-Seq_MCF-7_Human	2.35159788
11	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.21355905
12	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.13592447
13	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	2.12066635
14	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	2.08307204
15	SOX9_24532713_ChIP-Seq_HFSC_Mouse	2.01299451
16	TP63_17297297_ChIP-ChIP_HaCaT_Human	11.1128966
17	* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.93982025
18	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.88437908
19	SOX2_20726797_ChIP-Seq_SW620_Human	1.88024743
20	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.86140613
21	ATF3_27146783_Chip-Seq_COLON_Human	1.75879838
22	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.74030677
23	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.73916808
24	* GATA6_21074721_ChIP-Seq_CACO-2_Human	1.66216546
25	TP63_23658742_ChIP-Seq_EP156T_Human	1.63961167
26	TP63_22573176_ChIP-Seq_HFKS_Human	1.63563216
27	* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.60699897
28	* ERG_20517297_ChIP-Seq_VCAP_Human	1.56557761
29	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.53874405
30	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.51413076
31	KLF5_25053715_ChIP-Seq_YYC3_Human	1.48594936
32	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.46614690
33	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.45894187
34	CTCF_27219007_Chip-Seq_Bcells_Human	1.45624915
35	RXR_22108803_ChIP-Seq_LS180_Human	1.43604859
36	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.41997859
37	RACK7_27058665_Chip-Seq_MCF-7_Human	1.41216459
38	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.29100907
39	VDR_22108803_ChIP-Seq_LS180_Human	1.26541112
40	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.26441943
41	EGR1_19032775_ChIP-ChIP_M12_Human	1.26372073
42	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.24868396
43	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.24173920
44	CJUN_26792858_Chip-Seq_BT549_Human	1.19577890
45	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.19418668
46	* SMC4_20622854_ChIP-Seq_HELA_Human	1.19301465
47	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.17759013
48	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.16863900
49	E2F1_20622854_ChIP-Seq_HELA_Human	1.13967958
50	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.12580651
51	CTCF_20526341_ChIP-Seq_ESCs_Human	1.12211098
52	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.11715149
53	RBPJ_21746931_ChIP-Seq_IB4_Human	1.09822904
54	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.05241755
55	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.03548336
56	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.00454954
57	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.00449430
58	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.00233951
59	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.00113823
60	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.99657349
61	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.97907729
62	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.97734306
63	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97036780
64	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.95026484
65	HTT_18923047_ChIP-ChIP_STHdh_Human	0.93586641
66	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.92757067
67	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.91840149
68	BCOR_27268052_Chip-Seq_Bcells_Human	0.91080302
69	CLOCK_20551151_ChIP-Seq_293T_Human	0.90545605
70	AHR_22903824_ChIP-Seq_MCF-7_Human	0.90530318
71	UBF1/2_26484160_Chip-Seq_HMECs_Human	0.90294211
72	* GATA6_25053715_ChIP-Seq_YYC3_Human	0.90170214
73	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.87010384
74	LXR_22292898_ChIP-Seq_THP-1_Human	0.83761272
75	* GATA4_25053715_ChIP-Seq_YYC3_Human	0.83729516
76	P300_27058665_Chip-Seq_ZR-75-30cells_Human	0.83528518
77	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.83159699
78	SA1_27219007_Chip-Seq_Bcells_Human	0.81594572
79	TRIM28_21343339_ChIP-Seq_HEK293_Human	0.81161763
80	NANOG_20526341_ChIP-Seq_ESCs_Human	0.80359447
81	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.79625236
82	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.79520874
83	P53_21459846_ChIP-Seq_SAOS-2_Human	0.79288313
84	CEBPB_22108803_ChIP-Seq_LS180_Human	0.78681772
85	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.77333107
86	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.75860084
87	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.75162202
88	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.74676337
89	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.74081742
90	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.72983575
91	KDM2B_26808549_Chip-Seq_DND41_Human	0.72983191
92	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	0.72666536
93	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	0.72614621
94	KDM2B_26808549_Chip-Seq_SUP-B15_Human	0.72485769
95	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.70926540
96	TBX20_22080862_ChIP-Seq_HEART_Mouse	0.70926540
97	PPARA_22158963_ChIP-Seq_LIVER_Mouse	0.70891590
98	CREB1_26743006_Chip-Seq_LNCaP_Human	0.70310192
99	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	0.69949414
100	PRDM14_21183938_ChIP-Seq_MESCs_Mouse	0.68288814

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002796_impaired_skin_barrier	9.03253623
2	MP0010234_abnormal_vibrissa_follicle	8.77210259
3	MP0005275_abnormal_skin_tensile	6.43857398
4	MP0000579_abnormal_nail_morphology	5.26677673
5	MP0005501_abnormal_skin_physiology	5.23118523
6	MP0010678_abnormal_skin_adnexa	3.26759997
7	MP0003453_abnormal_keratinocyte_physiol	3.20727890
8	MP0001216_abnormal_epidermal_layer	2.97569040
9	MP0004885_abnormal_endolymph	2.93322895
10	MP0000467_abnormal_esophagus_morphology	2.92149736
11	MP0004043_abnormal_pH_regulation	2.74674554
12	MP0003878_abnormal_ear_physiology	2.72846323
13	MP0005377_hearing/vestibular/ear_phenot	2.72846323
14	MP0010771_integument_phenotype	2.60315348
15	MP0003941_abnormal_skin_development	2.26596537
16	MP0002060_abnormal_skin_morphology	2.21908694
17	MP0010352_gastrointestinal_tract_polyps	2.16348414
18	MP0002098_abnormal_vibrissa_morphology	2.15432900
19	MP0000383_abnormal_hair_follicle	2.13621149
20	MP0004264_abnormal_extraembryonic_tissu	1.99165963
21	MP0005409_darkened_coat_color	1.98839996
22	MP0000377_abnormal_hair_follicle	1.93959476
23	MP0000762_abnormal_tongue_morphology	1.90145243
24	MP0003705_abnormal_hypodermis_morpholog	1.89091575
25	MP0004947_skin_inflammation	1.75417836
26	MP0004381_abnormal_hair_follicle	1.65497715
27	MP0000465_gastrointestinal_hemorrhage	1.61823957
28	MP0000566_synostosis	1.48638231
29	MP0009931_abnormal_skin_appearance	1.45815857
30	MP0003191_abnormal_cellular_cholesterol	1.36910594
31	MP0003566_abnormal_cell_adhesion	1.30514452
32	MP0004782_abnormal_surfactant_physiolog	1.27646743
33	MP0004185_abnormal_adipocyte_glucose	1.27249508
34	MP0001851_eye_inflammation	1.25174794
35	MP0001188_hyperpigmentation	1.13158559
36	MP0000427_abnormal_hair_cycle	1.10953404
37	MP0002095_abnormal_skin_pigmentation	1.10053111
38	MP0000367_abnormal_coat/_hair	1.07527128
39	MP0009053_abnormal_anal_canal	1.00433001
40	MP0005023_abnormal_wound_healing	0.98369769
41	MP0001191_abnormal_skin_condition	0.98062414
42	MP0000647_abnormal_sebaceous_gland	0.89788738
43	MP0001243_abnormal_dermal_layer	0.84953387
44	MP0001784_abnormal_fluid_regulation	0.82842232
45	MP0009780_abnormal_chondrocyte_physiolo	0.75178009
46	MP0005503_abnormal_tendon_morphology	0.74458650
47	MP0002234_abnormal_pharynx_morphology	0.71583744
48	MP0005666_abnormal_adipose_tissue	0.66731338
49	MP0008004_abnormal_stomach_pH	0.66052807
50	MP0003011_delayed_dark_adaptation	0.62645623
51	MP0005375_adipose_tissue_phenotype	0.56846030
52	MP0010030_abnormal_orbit_morphology	0.56104295
53	MP0003315_abnormal_perineum_morphology	0.56035981
54	MP0000678_abnormal_parathyroid_gland	0.54687927
55	MP0000470_abnormal_stomach_morphology	0.50034964
56	MP0009333_abnormal_splenocyte_physiolog	0.49670393
57	MP0001485_abnormal_pinna_reflex	0.47396918
58	MP0002138_abnormal_hepatobiliary_system	0.44963243
59	MP0003950_abnormal_plasma_membrane	0.40342317
60	MP0001765_abnormal_ion_homeostasis	0.38957273
61	MP0002111_abnormal_tail_morphology	0.37094756
62	MP0003755_abnormal_palate_morphology	0.35622379
63	MP0003724_increased_susceptibility_to	0.34442862
64	MP0000003_abnormal_adipose_tissue	0.34306048
65	MP0001340_abnormal_eyelid_morphology	0.34162169
66	MP0003828_pulmonary_edema	0.33443490
67	MP0001502_abnormal_circadian_rhythm	0.29088367
68	MP0004197_abnormal_fetal_growth/weight/	0.27381591
69	MP0002177_abnormal_outer_ear	0.25518485
70	MP0003638_abnormal_response/metabolism_	0.24719772
71	MP0002249_abnormal_larynx_morphology	0.24426082
72	MP0010368_abnormal_lymphatic_system	0.24191625
73	MP0000371_diluted_coat_color	0.22666203
74	MP0002877_abnormal_melanocyte_morpholog	0.22080359
75	MP0001186_pigmentation_phenotype	0.21492578
76	MP0001879_abnormal_lymphatic_vessel	0.20888173
77	MP0000685_abnormal_immune_system	0.20047391
78	MP0005193_abnormal_anterior_eye	0.18706727
79	MP0002006_tumorigenesis	0.18147497
80	MP0000627_abnormal_mammary_gland	0.17128371
81	MP0009115_abnormal_fat_cell	0.16847677
82	MP0005388_respiratory_system_phenotype	0.16557631
83	MP0002133_abnormal_respiratory_system	0.16557631
84	MP0008569_lethality_at_weaning	0.15963776
85	MP0002075_abnormal_coat/hair_pigmentati	0.15405785
86	MP0002282_abnormal_trachea_morphology	0.14936525
87	MP0002166_altered_tumor_susceptibility	0.14933190
88	MP0002108_abnormal_muscle_morphology	0.13212145
89	MP0009379_abnormal_foot_pigmentation	0.12700179
90	MP0000613_abnormal_salivary_gland	0.12297533
91	MP0003763_abnormal_thymus_physiology	0.11622767
92	MP0003300_gastrointestinal_ulcer	0.11126823
93	MP0008789_abnormal_olfactory_epithelium	0.10641242
94	MP0005636_abnormal_mineral_homeostasis	0.10506664
95	MP0005076_abnormal_cell_differentiation	0.09607324
96	MP0001533_abnormal_skeleton_physiology	0.09564480
97	MP0003436_decreased_susceptibility_to	0.09550792
98	MP0005166_decreased_susceptibility_to	0.08847534
99	MP0003045_fibrosis	0.08644482
100	MP0000477_abnormal_intestine_morphology	0.08532868

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Oral leukoplakia (HP:0002745)	9.61575911
2	Increased IgE level (HP:0003212)	9.01830482
3	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	8.70065529
4	Palmoplantar hyperkeratosis (HP:0000972)	8.46314646
5	Erythroderma (HP:0001019)	8.28936848
6	Congenital ichthyosiform erythroderma (HP:0007431)	8.13030440
7	Palmar hyperkeratosis (HP:0010765)	8.04025970
8	Plantar hyperkeratosis (HP:0007556)	6.84109343
9	Parakeratosis (HP:0001036)	6.49205915
10	Alopecia of scalp (HP:0002293)	6.27207410
11	Onycholysis (HP:0001806)	5.94206415
12	Erythema (HP:0010783)	5.78214367
13	Thick nail (HP:0001805)	5.55333619
14	Corneal erosion (HP:0200020)	5.44329916
15	Pustule (HP:0200039)	5.41646479
16	Hypotrichosis (HP:0001006)	4.82067473
17	Abnormality of the axillary hair (HP:0100134)	4.64609029
18	Abnormality of secondary sexual hair (HP:0009888)	4.64609029
19	Lip pit (HP:0100267)	4.52114396
20	Ectropion (HP:0000656)	4.44000384
21	Nail dystrophy (HP:0008404)	4.20171954
22	Hypohidrosis (HP:0000966)	4.09222306
23	Gangrene (HP:0100758)	4.05026194
24	Right ventricular cardiomyopathy (HP:0011663)	3.90350383
25	Palmoplantar keratoderma (HP:0000982)	3.82755567
26	Fragile nails (HP:0001808)	3.66176504
27	Absent eyelashes (HP:0000561)	3.53303868
28	Sparse scalp hair (HP:0002209)	3.37874081
29	Abnormality of the salivary glands (HP:0010286)	3.28863611
30	Absent hair (HP:0002298)	3.28571889
31	Furrowed tongue (HP:0000221)	3.28485758
32	Follicular hyperkeratosis (HP:0007502)	3.14411312
33	Sparse eyelashes (HP:0000653)	3.13290511
34	Woolly hair (HP:0002224)	3.10555173
35	Amniotic constriction ring (HP:0009775)	3.05277208
36	Abnormality of placental membranes (HP:0011409)	3.05277208
37	Abnormal blistering of the skin (HP:0008066)	2.94342357
38	Brittle hair (HP:0002299)	2.90933421
39	Dehydration (HP:0001944)	2.75310976
40	Conjunctival hamartoma (HP:0100780)	2.71073374
41	Autoamputation (HP:0001218)	2.65780553
42	Pruritus (HP:0000989)	2.61745467
43	Urticaria (HP:0001025)	2.57939117
44	Villous atrophy (HP:0011473)	2.54614659
45	Abnormality of small intestinal villus morphology (HP:0011472)	2.54614659
46	Lack of skin elasticity (HP:0100679)	2.52458478
47	Hypergammaglobulinemia (HP:0010702)	2.36935099
48	Blepharitis (HP:0000498)	2.33182442
49	Laryngomalacia (HP:0001601)	2.32736941
50	Multifactorial inheritance (HP:0001426)	2.25457232
51	Paralysis (HP:0003470)	2.19223351
52	Acanthosis nigricans (HP:0000956)	2.18429325
53	Ridged nail (HP:0001807)	2.06695712
54	Recurrent corneal erosions (HP:0000495)	2.00200487
55	Abnormality of nail color (HP:0100643)	12.5387405
56	Hypoplastic labia majora (HP:0000059)	1.89775396
57	Hyperactive renin-angiotensin system (HP:0000841)	1.89557949
58	Milia (HP:0001056)	1.87980113
59	Verrucae (HP:0200043)	1.87329008
60	Papilloma (HP:0012740)	1.87329008
61	Corneal dystrophy (HP:0001131)	1.87229515
62	Hyperhidrosis (HP:0000975)	1.85231822
63	Eczematoid dermatitis (HP:0000976)	1.81382557
64	Anonychia (HP:0001798)	1.80279116
65	Hamartoma of the eye (HP:0010568)	1.78775835
66	Fine hair (HP:0002213)	1.77595935
67	Keratoconjunctivitis sicca (HP:0001097)	1.76646929
68	Sepsis (HP:0100806)	1.74646361
69	Hyperkalemia (HP:0002153)	1.72349584
70	Pili torti (HP:0003777)	1.71912413
71	Abnormality of the labia majora (HP:0012881)	1.71742822
72	Melanocytic nevus (HP:0000995)	1.70356397
73	Natal tooth (HP:0000695)	1.69304607
74	Advanced eruption of teeth (HP:0006288)	1.68920783
75	Oligodontia (HP:0000677)	1.67403584
76	Dry skin (HP:0000958)	1.66347571
77	Abnormal hair laboratory examination (HP:0003328)	1.65463974
78	Popliteal pterygium (HP:0009756)	1.62645216
79	Abnormality of hair growth rate (HP:0011363)	1.62311802
80	Slow-growing hair (HP:0002217)	1.62311802
81	Recurrent bacterial skin infections (HP:0005406)	1.59488317
82	Hypoplastic toenails (HP:0001800)	1.58963382
83	Keratoconjunctivitis (HP:0001096)	1.58771102
84	Skin ulcer (HP:0200042)	1.55881044
85	Carious teeth (HP:0000670)	1.55673217
86	Abnormality of the fingernails (HP:0001231)	1.47382503
87	Preauricular skin tag (HP:0000384)	1.44853275
88	Distal lower limb muscle weakness (HP:0009053)	1.43936062
89	Axonal loss (HP:0003447)	1.41095008
90	Split foot (HP:0001839)	1.38208923
91	Nasal polyposis (HP:0100582)	1.35026731
92	Abnormality of the neuromuscular junction (HP:0003398)	1.32552642
93	Fatigable weakness (HP:0003473)	1.32552642
94	Skin pits (HP:0100276)	1.32004634
95	Labial hypoplasia (HP:0000066)	1.28694894
96	Xerostomia (HP:0000217)	1.24655201
97	Skin tags (HP:0010609)	1.23793356
98	Seborrheic dermatitis (HP:0001051)	1.23182709
99	Curly hair (HP:0002212)	1.23150219
100	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.22674821

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K9	5.41718866
2	EPHA2	4.56733921
3	MAP3K2	3.42249236
4	MAP3K6	3.35978975
5	STK24	3.21005657
6	MAP3K3	3.05631438
7	TGFBR1	3.04975841
8	FER	2.91618504
9	RIPK1	2.67153133
10	MAPKAPK3	2.66125940
11	SGK494	2.38341972
12	SGK223	2.38341972
13	ERN1	2.25294801
14	EPHA3	2.18773365
15	NME1	1.78814274
16	MST4	1.76266716
17	TAOK1	1.65648906
18	FGFR3	1.60723973
19	GRK6	1.54841001
20	EPHB1	1.52088638
21	TRPM7	1.50037526
22	IRAK1	1.44058705
23	TYRO3	1.42929553
24	BLK	1.41173650
25	WNK1	1.40958692
26	FGFR1	1.36745904
27	MST1R	1.35970740
28	PTK2	1.31216606
29	MARK2	1.29298884
30	LATS1	1.24187470
31	MAP3K1	1.22628989
32	ERBB3	1.20291932
33	CAMK1D	1.20127369
34	EPHB2	1.19169629
35	DMPK	1.17241916
36	MET	1.12820581
37	LRRK2	1.11805147
38	MAP2K6	1.10569461
39	SGK3	1.04060526
40	MAP3K7	0.97247828
41	SGK2	0.96949413
42	MAPK7	0.92486943
43	FGFR4	0.89341582
44	TRIB3	0.88712238
45	CAMK1G	0.87093537
46	IKBKE	0.85962017
47	IKBKB	0.82644101
48	PRKD2	0.81323176
49	CDK12	0.73980999
50	BCR	0.73894154
51	FGR	0.67676985
52	RPS6KB2	0.67588859
53	MAP3K13	0.67025075
54	KSR2	0.66947900
55	MAP3K12	0.65133814
56	STK3	0.64268292
57	STK38	0.64116114
58	SGK1	0.62009904
59	BMX	0.60483794
60	HIPK2	0.58390014
61	PRKAA2	0.57757370
62	MAPKAPK2	0.56577729
63	NLK	0.55339545
64	JAK3	0.55213781
65	IRAK4	0.53844270
66	PDGFRB	0.53694692
67	IRAK3	0.52861681
68	TBK1	0.51585779
69	CSK	0.51288507
70	PBK	0.51045924
71	SIK3	0.50492729
72	TTN	0.49725183
73	SIK1	0.49129128
74	RPS6KB1	0.48276605
75	MTOR	0.48275033
76	IRAK2	0.48010469
77	CDC42BPA	0.46610025
78	STK38L	0.45527821
79	RET	0.45276130
80	PDGFRA	0.43440099
81	LATS2	0.40888280
82	PTK6	0.38542369
83	WNK4	0.34127910
84	STK39	0.32570072
85	GSK3A	0.30592506
86	ABL2	0.28382255
87	CHUK	0.26797278
88	PRPF4B	0.26693702
89	AKT2	0.26149669
90	MAP3K14	0.24329970
91	PDK2	0.23895025
92	ZAP70	0.23522940
93	STK10	0.23295183
94	HCK	0.22768146
95	TGFBR2	0.22617343
96	PRKCI	0.22516541
97	OBSCN	0.21924413
98	RPS6KA1	0.21093289
99	TAOK3	0.20366393
100	ADRBK1	0.20256091

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	6.27711567
2	Linoleic acid metabolism_Homo sapiens_hsa00591	5.07557592
3	Arachidonic acid metabolism_Homo sapiens_hsa00590	4.21969101
4	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	3.80350438
5	Ether lipid metabolism_Homo sapiens_hsa00565	3.51356311
6	GnRH signaling pathway_Homo sapiens_hsa04912	2.23258434
7	VEGF signaling pathway_Homo sapiens_hsa04370	2.16917905
8	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	2.11834068
9	Circadian rhythm_Homo sapiens_hsa04710	1.96225779
10	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.94081739
11	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.90917267
12	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.77567070
13	Amoebiasis_Homo sapiens_hsa05146	1.71070703
14	Long-term depression_Homo sapiens_hsa04730	1.58628015
15	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.55043205
16	Salivary secretion_Homo sapiens_hsa04970	1.51996254
17	Serotonergic synapse_Homo sapiens_hsa04726	1.48816918
18	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.44979781
19	Sphingolipid metabolism_Homo sapiens_hsa00600	1.43056897
20	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.33348374
21	Histidine metabolism_Homo sapiens_hsa00340	1.32744729
22	Choline metabolism in cancer_Homo sapiens_hsa05231	1.25548033
23	Acute myeloid leukemia_Homo sapiens_hsa05221	1.24872785
24	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.18655751
25	Ras signaling pathway_Homo sapiens_hsa04014	1.13509523
26	Pertussis_Homo sapiens_hsa05133	1.08293642
27	Phototransduction_Homo sapiens_hsa04744	1.03460661
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.99393472
29	Adherens junction_Homo sapiens_hsa04520	0.97394333
30	Platelet activation_Homo sapiens_hsa04611	0.85696079
31	Renin secretion_Homo sapiens_hsa04924	0.85046760
32	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.83764548
33	Phenylalanine metabolism_Homo sapiens_hsa00360	0.81728856
34	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.75940655
35	Fat digestion and absorption_Homo sapiens_hsa04975	0.74907074
36	Pancreatic secretion_Homo sapiens_hsa04972	0.73431676
37	Bladder cancer_Homo sapiens_hsa05219	0.73071585
38	Tight junction_Homo sapiens_hsa04530	0.73059764
39	Notch signaling pathway_Homo sapiens_hsa04330	0.72931322
40	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.71895194
41	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.71259948
42	Renal cell carcinoma_Homo sapiens_hsa05211	0.70986040
43	Insulin signaling pathway_Homo sapiens_hsa04910	0.68578291
44	Hepatitis C_Homo sapiens_hsa05160	0.65602891
45	Influenza A_Homo sapiens_hsa05164	0.64586536
46	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.64535217
47	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.64433411
48	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.64417657
49	Arginine biosynthesis_Homo sapiens_hsa00220	0.62436116
50	Endocytosis_Homo sapiens_hsa04144	0.61752219
51	Tuberculosis_Homo sapiens_hsa05152	0.60308103
52	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.59633754
53	MAPK signaling pathway_Homo sapiens_hsa04010	0.58899059
54	Long-term potentiation_Homo sapiens_hsa04720	0.57712110
55	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.53167313
56	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.53128950
57	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.53030505
58	Glioma_Homo sapiens_hsa05214	0.52836977
59	Salmonella infection_Homo sapiens_hsa05132	0.52785755
60	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.51034881
61	Shigellosis_Homo sapiens_hsa05131	0.49658194
62	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.48818684
63	Pancreatic cancer_Homo sapiens_hsa05212	0.48232555
64	MicroRNAs in cancer_Homo sapiens_hsa05206	0.48054576
65	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.46749364
66	Glutamatergic synapse_Homo sapiens_hsa04724	0.46268041
67	Thyroid cancer_Homo sapiens_hsa05216	0.46047291
68	Gastric acid secretion_Homo sapiens_hsa04971	0.44239076
69	Axon guidance_Homo sapiens_hsa04360	0.43289534
70	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.42610099
71	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.42115524
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.41953901
73	TNF signaling pathway_Homo sapiens_hsa04668	0.41785147
74	Rap1 signaling pathway_Homo sapiens_hsa04015	0.40249073
75	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.40050309
76	Glucagon signaling pathway_Homo sapiens_hsa04922	0.39469772
77	Galactose metabolism_Homo sapiens_hsa00052	0.39045993
78	Retinol metabolism_Homo sapiens_hsa00830	0.38877548
79	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.38691518
80	ErbB signaling pathway_Homo sapiens_hsa04012	0.38405682
81	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.37918811
82	Melanogenesis_Homo sapiens_hsa04916	0.37421103
83	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.36977676
84	Malaria_Homo sapiens_hsa05144	0.35798704
85	Estrogen signaling pathway_Homo sapiens_hsa04915	0.35687753
86	PPAR signaling pathway_Homo sapiens_hsa03320	0.35118133
87	p53 signaling pathway_Homo sapiens_hsa04115	0.34993325
88	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.31255447
89	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.31166178
90	Toxoplasmosis_Homo sapiens_hsa05145	0.29767188
91	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.29579520
92	Proteoglycans in cancer_Homo sapiens_hsa05205	0.29388339
93	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.26491735
94	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.26269580
95	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.26148075
96	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.25835781
97	Renin-angiotensin system_Homo sapiens_hsa04614	0.25770826
98	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.25489317
99	Insulin resistance_Homo sapiens_hsa04931	0.23925067
100	Pathways in cancer_Homo sapiens_hsa05200	0.23908854

SPRR2A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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