SPRR2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma secretion (GO:0072643)9.93618765
2desmosome organization (GO:0002934)9.82644934
3* keratinization (GO:0031424)9.71712758
4citrulline metabolic process (GO:0000052)9.56732630
5maintenance of gastrointestinal epithelium (GO:0030277)9.49328953
6long-chain fatty acid biosynthetic process (GO:0042759)9.43723487
7negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)8.94126853
8molting cycle (GO:0042303)8.78106634
9hair cycle (GO:0042633)8.78106634
10multicellular organismal water homeostasis (GO:0050891)8.71282422
11detection of other organism (GO:0098543)8.60732477
12lipoxygenase pathway (GO:0019372)8.24954125
13positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)7.87243969
14regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)7.87243969
15peptidyl-arginine modification (GO:0018195)7.80102267
16positive regulation of osteoblast proliferation (GO:0033690)7.58796237
17lung lobe morphogenesis (GO:0060463)7.54504968
18epithelial structure maintenance (GO:0010669)7.49178566
19linoleic acid metabolic process (GO:0043651)7.47180698
20regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)7.46534723
21lung vasculature development (GO:0060426)7.39625137
22regulation of natural killer cell differentiation (GO:0032823)7.27759539
23water homeostasis (GO:0030104)7.23673499
24keratinocyte proliferation (GO:0043616)7.14636987
25complement activation, alternative pathway (GO:0006957)7.01213553
26regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033397.01037042
27positive regulation of astrocyte differentiation (GO:0048711)6.63713558
28negative regulation of interferon-gamma production (GO:0032689)6.39264902
29hemidesmosome assembly (GO:0031581)6.27523616
30positive regulation of monocyte chemotaxis (GO:0090026)6.27115486
31sequestering of metal ion (GO:0051238)6.20554504
32regulation of nephron tubule epithelial cell differentiation (GO:0072182)6.13975969
33sulfate transmembrane transport (GO:1902358)6.09593354
34negative regulation of interleukin-17 production (GO:0032700)5.69044042
35regulation of T cell chemotaxis (GO:0010819)5.66233863
36positive regulation of T cell chemotaxis (GO:0010820)5.66233863
37phosphatidylserine acyl-chain remodeling (GO:0036150)5.55935606
38regulation of toll-like receptor 4 signaling pathway (GO:0034143)5.51480846
39tyrosine phosphorylation of STAT protein (GO:0007260)5.49555911
40muscle organ morphogenesis (GO:0048644)5.47987204
41intermediate filament cytoskeleton organization (GO:0045104)5.38926394
42phosphatidylglycerol acyl-chain remodeling (GO:0036148)5.30838332
43wound healing, spreading of epidermal cells (GO:0035313)5.25120952
44regulation of epithelial cell differentiation involved in kidney development (GO:2000696)5.24397945
45phosphatidylinositol acyl-chain remodeling (GO:0036149)5.23018484
46intermediate filament-based process (GO:0045103)5.22079391
47positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)5.11749171
48* keratinocyte differentiation (GO:0030216)5.11431390
49gap junction assembly (GO:0016264)5.09541987
50detection of external biotic stimulus (GO:0098581)5.07052223
51ectoderm development (GO:0007398)4.94798354
52response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.94597505
53response to host immune response (GO:0052572)4.94597505
54intermediate filament organization (GO:0045109)4.94545382
55sulfate transport (GO:0008272)4.91506333
56positive regulation of toll-like receptor signaling pathway (GO:0034123)4.76690710
57response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.60931147
58response to host (GO:0075136)4.60931147
59response to host defenses (GO:0052200)4.60931147
60regulation of monocyte chemotaxis (GO:0090025)4.57548986
61regulation of complement activation (GO:0030449)4.50805217
624-hydroxyproline metabolic process (GO:0019471)4.50801963
63* epidermis development (GO:0008544)4.48480843
64decidualization (GO:0046697)4.41590197
65detection of biotic stimulus (GO:0009595)4.33769333
66ceramide biosynthetic process (GO:0046513)4.31413187
67positive regulation of metanephros development (GO:0072216)4.27019621
68regulation of protein activation cascade (GO:2000257)4.18231657
69O-glycan processing (GO:0016266)4.18099038
70peptidyl-proline hydroxylation (GO:0019511)4.17997262
71defense response to fungus (GO:0050832)4.11465923
72defense response to Gram-negative bacterium (GO:0050829)4.06097143
73surfactant homeostasis (GO:0043129)4.02524588
74regulation of RIG-I signaling pathway (GO:0039535)4.02313181
75positive regulation of cellular amide metabolic process (GO:0034250)4.00834026
76phosphatidylserine metabolic process (GO:0006658)3.96189756
77* epithelium development (GO:0060429)3.84667606
78phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.79164656
79positive regulation of macrophage differentiation (GO:0045651)3.78142952
80wound healing, spreading of cells (GO:0044319)3.77191038
81regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.74763888
82phospholipid catabolic process (GO:0009395)3.74164885
83* epidermal cell differentiation (GO:0009913)3.73502983
84antimicrobial humoral response (GO:0019730)3.69853591
85trophoblast giant cell differentiation (GO:0060707)3.66258040
86positive regulation of epidermis development (GO:0045684)3.65111970
87antibacterial humoral response (GO:0019731)3.62066259
88establishment of planar polarity (GO:0001736)3.61966057
89establishment of tissue polarity (GO:0007164)3.61966057
90regulation of apoptotic cell clearance (GO:2000425)3.61196667
91positive regulation of granulocyte chemotaxis (GO:0071624)3.49291304
92branching involved in salivary gland morphogenesis (GO:0060445)3.43002960
93keratinocyte development (GO:0003334)3.42731858
94regulation of osteoblast proliferation (GO:0033688)3.42353551
95chemical homeostasis within a tissue (GO:0048875)3.42345060
96innate immune response in mucosa (GO:0002227)3.41784456
97cell differentiation involved in embryonic placenta development (GO:0060706)3.41405916
98cytoskeletal anchoring at plasma membrane (GO:0007016)3.41165684
99regulation of lymphocyte chemotaxis (GO:1901623)3.41039759
100regulation of natural killer cell activation (GO:0032814)3.35121084
101positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.34399707
102regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.34104657
103positive regulation of histone acetylation (GO:0035066)3.28646032
104regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.21703590
105regulation of transforming growth factor beta1 production (GO:0032908)3.17172304
106low-density lipoprotein particle clearance (GO:0034383)3.16647294
107regulation of interleukin-17 production (GO:0032660)3.12863028
108negative regulation of meiosis (GO:0045835)3.12740691
109regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.08867128
110regulation of axon regeneration (GO:0048679)3.07912386
111regulation of neuron projection regeneration (GO:0070570)3.07912386
112phosphatidylcholine acyl-chain remodeling (GO:0036151)3.07393017
113positive regulation of p38MAPK cascade (GO:1900745)3.05403084
114positive regulation of protein acetylation (GO:1901985)3.05117780
115positive regulation of peptidyl-lysine acetylation (GO:2000758)3.05117780
116alditol phosphate metabolic process (GO:0052646)3.01858379
117positive regulation of epidermal cell differentiation (GO:0045606)3.00218835
118protein hydroxylation (GO:0018126)2.98004126
119* epithelial cell differentiation (GO:0030855)2.97275801
120positive regulation of T cell migration (GO:2000406)2.95143425
121regulation of water loss via skin (GO:0033561)2.93937565
122eyelid development in camera-type eye (GO:0061029)2.93468572
123mucosal immune response (GO:0002385)2.92999130
124negative regulation of viral release from host cell (GO:1902187)2.90847466
125cell-substrate junction assembly (GO:0007044)2.90052544
126calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.87756542
127regulation of T cell migration (GO:2000404)2.85173189
128negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.84679674
129negative regulation of cell fate specification (GO:0009996)2.83310948
130negative regulation of osteoclast differentiation (GO:0045671)2.83138421
131response to UV-B (GO:0010224)2.81360419
132response to fungus (GO:0009620)2.79781256
133phospholipid efflux (GO:0033700)2.78508976
134phosphatidylglycerol metabolic process (GO:0046471)2.76512718
135positive regulation of cholesterol efflux (GO:0010875)2.76342395
136regulation of humoral immune response (GO:0002920)2.75225370
137organ or tissue specific immune response (GO:0002251)2.74932973
138myotube differentiation (GO:0014902)2.73254589
139negative regulation of keratinocyte proliferation (GO:0010839)2.72997533
140regulation of metanephros development (GO:0072215)2.72589632
141regulation of respiratory burst (GO:0060263)2.72582634
142cellular modified amino acid biosynthetic process (GO:0042398)2.69795149
143planar cell polarity pathway involved in neural tube closure (GO:0090179)2.67277241
144phosphatidic acid metabolic process (GO:0046473)2.66509145
145phosphatidic acid biosynthetic process (GO:0006654)2.66509145
146negative regulation of lymphocyte differentiation (GO:0045620)2.65583636
147skin morphogenesis (GO:0043589)2.61885068
148positive regulation of response to biotic stimulus (GO:0002833)2.61382754
149regulation of epidermis development (GO:0045682)2.59933215
150sphingolipid biosynthetic process (GO:0030148)2.59573353
151granulocyte differentiation (GO:0030851)2.55945796
152positive regulation of glial cell differentiation (GO:0045687)2.55491023
153digestive system process (GO:0022600)2.55451417
154regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.55054406
155bundle of His cell to Purkinje myocyte communication (GO:0086069)2.54237681
156fatty acid elongation (GO:0030497)2.52772193
157detection of bacterium (GO:0016045)2.51988589
158defense response to Gram-positive bacterium (GO:0050830)2.50446432
159regulation of triglyceride biosynthetic process (GO:0010866)2.50015708
160cellular response to arsenic-containing substance (GO:0071243)2.47226009
161negative regulation of interleukin-6 production (GO:0032715)2.45899856
162positive regulation of cholesterol transport (GO:0032376)2.42794834
163positive regulation of sterol transport (GO:0032373)2.42794834
164regulation of keratinocyte differentiation (GO:0045616)2.40829581
165regulation of hair cycle (GO:0042634)2.40607370
166positive regulation of lymphocyte migration (GO:2000403)2.39517335
167positive regulation of keratinocyte differentiation (GO:0045618)2.36604130
168positive regulation of humoral immune response (GO:0002922)2.35433271
169positive regulation of interleukin-8 secretion (GO:2000484)2.34343352
170regulation of granulocyte chemotaxis (GO:0071622)2.33579519
171positive regulation of glomerulus development (GO:0090193)2.33107402
172defense response to bacterium (GO:0042742)2.32555820
173regulation of interleukin-6 production (GO:0032675)2.27708597
174ventricular cardiac muscle cell action potential (GO:0086005)2.25535694
175response to zinc ion (GO:0010043)2.23012927
176hair follicle morphogenesis (GO:0031069)2.22721371
177establishment of skin barrier (GO:0061436)15.8342308
178citrulline biosynthetic process (GO:0019240)14.4998440
179peptide cross-linking (GO:0018149)11.0067617

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.89229996
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.68503433
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.57372662
4ESR1_15608294_ChIP-ChIP_MCF-7_Human4.52807247
5ESR1_21235772_ChIP-Seq_MCF-7_Human3.59102740
6ESR2_21235772_ChIP-Seq_MCF-7_Human3.27948166
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.08512438
8ZNF263_19887448_ChIP-Seq_K562_Human2.80583833
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.76321146
10HIF1A_21447827_ChIP-Seq_MCF-7_Human2.69244995
11CDX2_20551321_ChIP-Seq_CACO-2_Human2.59264487
12IKZF1_21737484_ChIP-ChIP_HCT116_Human2.50365342
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.44561475
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.29980000
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.22318145
16SOX2_20726797_ChIP-Seq_SW620_Human2.13861255
17KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.10104199
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.07904524
19* GATA6_21074721_ChIP-Seq_CACO-2_Mouse2.06721048
20PPAR_26484153_Chip-Seq_NCI-H1993_Human2.05193231
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.97806907
22DNAJC2_21179169_ChIP-ChIP_NT2_Human1.96148449
23SOX2_27498859_Chip-Seq_STOMACH_Mouse1.93869706
24CLOCK_20551151_ChIP-Seq_293T_Human1.89923159
25SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.89287118
26GATA6_21074721_ChIP-Seq_CACO-2_Human1.86310361
27ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.85237917
28TP63_23658742_ChIP-Seq_EP156T_Human1.84292198
29FOXO3_23340844_ChIP-Seq_DLD1_Human1.83433053
30TP63_22573176_ChIP-Seq_HFKS_Human1.76309642
31SCL_19346495_ChIP-Seq_HPC-7_Human1.75680632
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.71138402
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70749837
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.70566573
35KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.70512904
36ESR1_20079471_ChIP-ChIP_T-47D_Human1.66137817
37TCF4_18268006_ChIP-ChIP_LS174T_Human1.65922448
38VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.61116942
39SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.59335244
40SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.59335244
41RUNX1_27514584_Chip-Seq_MCF-7_Human1.56663008
42RACK7_27058665_Chip-Seq_MCF-7_Human1.55319497
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55182153
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.53165196
45CTCF_27219007_Chip-Seq_Bcells_Human1.50937532
46ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.48918303
47GATA4_25053715_ChIP-Seq_YYC3_Human1.47042843
48LXR_22292898_ChIP-Seq_THP-1_Human1.45595610
49RXR_22108803_ChIP-Seq_LS180_Human1.44987567
50ATF3_27146783_Chip-Seq_COLON_Human1.44465439
51ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41681603
52AHR_22903824_ChIP-Seq_MCF-7_Human1.41478130
53GATA6_25053715_ChIP-Seq_YYC3_Human1.40843643
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.38873112
55KLF5_25053715_ChIP-Seq_YYC3_Human1.37715625
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36961792
57ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36219273
58RXR_22158963_ChIP-Seq_LIVER_Mouse1.35802204
59E2F1_20622854_ChIP-Seq_HELA_Human1.35305678
60EGR1_19032775_ChIP-ChIP_M12_Human1.34784986
61* SMC4_20622854_ChIP-Seq_HELA_Human1.32765347
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32194682
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.30221283
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29108442
65PPARA_22158963_ChIP-Seq_LIVER_Mouse1.28598022
66KDM2B_26808549_Chip-Seq_K562_Human1.27093664
67FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26568895
68POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26360033
69LXR_22158963_ChIP-Seq_LIVER_Mouse1.24434404
70JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23130853
71ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.22983476
72BCOR_27268052_Chip-Seq_Bcells_Human1.22836891
73GATA1_19941826_ChIP-Seq_K562_Human1.19929729
74SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.19151989
75* CTCF_20526341_ChIP-Seq_ESCs_Human1.16369053
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14625833
77FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.13936640
78UBF1/2_26484160_Chip-Seq_HMECs_Human1.11465872
79SA1_27219007_Chip-Seq_ERYTHROID_Human1.10184947
80TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08467449
81P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06449355
82EGR1_19374776_ChIP-ChIP_THP-1_Human1.06252032
83P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.06192430
84RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04185715
85BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.04180112
86NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04139183
87JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03180619
88ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02774825
89EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01563897
90GATA2_19941826_ChIP-Seq_K562_Human1.01431495
91* P53_21459846_ChIP-Seq_SAOS-2_Human1.01145160
92BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00793770
93AR_21909140_ChIP-Seq_LNCAP_Human0.98758178
94SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98508434
95SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98320635
96P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97998443
97KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97551994
98ARNT_22903824_ChIP-Seq_MCF-7_Human0.96981493
99GATA3_24758297_ChIP-Seq_MCF-7_Human0.96842980
100NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96557737
101RBPJ_21746931_ChIP-Seq_IB4_Human0.94527469
102TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94052708
103ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93026630
104CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.92641849
105CJUN_26792858_Chip-Seq_BT549_Human0.92313409
106NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91253936
107ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90901221
108ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.88746190
109GATA2_21666600_ChIP-Seq_HMVEC_Human0.88736365
110* BCL6_27268052_Chip-Seq_Bcells_Human0.88074749
111CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88029782
112UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87592679
113DROSHA_22980978_ChIP-Seq_HELA_Human0.86971163
114ERG_20517297_ChIP-Seq_VCAP_Human0.86772352
115FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86503455
116* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.86400066
117CREB1_26743006_Chip-Seq_LNCaP_Human0.85867139
118NANOG_20526341_ChIP-Seq_ESCs_Human0.85103499
119CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85049349
120WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84721273
121NCOR_22424771_ChIP-Seq_293T_Human0.84639647
122THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84579423
123SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.84366926
124SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.84049403
125P300_27268052_Chip-Seq_Bcells_Human0.82643101
126KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.82068839
127STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.81768946
128P68_20966046_ChIP-Seq_HELA_Human0.81395314
129TAF2_19829295_ChIP-Seq_ESCs_Human0.80105119
130TCF7_22412390_ChIP-Seq_EML_Mouse0.79909479
131FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.79828881
132GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.79730207
133POU5F1_16518401_ChIP-PET_MESCs_Mouse0.79051105
134* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.78398247
135RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.78388279
136SA1_27219007_Chip-Seq_Bcells_Human0.77363173
137EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.77001232
138HNFA_21074721_ChIP-Seq_CACO-2_Human0.76537490
139RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.76021364
140CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.75414257
141YY1_22570637_ChIP-Seq_MALME-3M_Human0.75174554
142HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.74315828
143CEBPB_22108803_ChIP-Seq_LS180_Human0.70069327
144JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.68707246
145AUTS2_25519132_ChIP-Seq_293T-REX_Human0.67544015
146TP53_18474530_ChIP-ChIP_U2OS_Human0.67174161
147KDM2B_26808549_Chip-Seq_DND41_Human0.66612085
148HTT_18923047_ChIP-ChIP_STHdh_Human0.65698649

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle9.40662482
2MP0000579_abnormal_nail_morphology6.29472643
3MP0004885_abnormal_endolymph5.46884047
4MP0005083_abnormal_biliary_tract3.89265720
5MP0002796_impaired_skin_barrier3.57900372
6MP0003941_abnormal_skin_development3.33594453
7MP0010678_abnormal_skin_adnexa3.25641723
8MP0003878_abnormal_ear_physiology3.18579514
9MP0005377_hearing/vestibular/ear_phenot3.18579514
10MP0003866_abnormal_defecation2.88968388
11MP0003436_decreased_susceptibility_to2.74345191
12MP0001666_abnormal_nutrient_absorption2.64601126
13MP0004264_abnormal_extraembryonic_tissu2.53863621
14MP0001485_abnormal_pinna_reflex2.46811423
15MP0004381_abnormal_hair_follicle2.38586718
16MP0000537_abnormal_urethra_morphology2.32278620
17MP0003191_abnormal_cellular_cholesterol2.27957572
18MP0003705_abnormal_hypodermis_morpholog2.16929047
19MP0001849_ear_inflammation2.16863921
20MP0005085_abnormal_gallbladder_physiolo2.12942435
21MP0005501_abnormal_skin_physiology2.09552417
22MP0008004_abnormal_stomach_pH1.91149432
23MP0003303_peritoneal_inflammation1.90901415
24MP0005409_darkened_coat_color1.90515747
25MP0001765_abnormal_ion_homeostasis1.88946997
26MP0002909_abnormal_adrenal_gland1.88325298
27MP0001188_hyperpigmentation1.86857064
28MP0004019_abnormal_vitamin_homeostasis1.86644206
29MP0002254_reproductive_system_inflammat1.85528614
30MP0004782_abnormal_surfactant_physiolog1.85021944
31MP0003566_abnormal_cell_adhesion1.79258912
32MP0004947_skin_inflammation1.77006285
33MP0004742_abnormal_vestibular_system1.75772717
34MP0002098_abnormal_vibrissa_morphology1.75276230
35MP0009785_altered_susceptibility_to1.72731422
36MP0003045_fibrosis1.72417880
37MP0005275_abnormal_skin_tensile1.68834857
38MP0003453_abnormal_keratinocyte_physiol1.63252255
39MP0001216_abnormal_epidermal_layer1.62992834
40MP0005166_decreased_susceptibility_to1.61531065
41MP0006054_spinal_hemorrhage1.58960176
42MP0002060_abnormal_skin_morphology1.53247663
43MP0000383_abnormal_hair_follicle1.49739688
44MP0003075_altered_response_to1.47491373
45MP0010771_integument_phenotype1.46630037
46MP0001727_abnormal_embryo_implantation1.46301007
47MP0005310_abnormal_salivary_gland1.37336857
48MP0004272_abnormal_basement_membrane1.35434791
49MP0009053_abnormal_anal_canal1.29154210
50MP0001881_abnormal_mammary_gland1.28250378
51MP0000465_gastrointestinal_hemorrhage1.27965155
52MP0001191_abnormal_skin_condition1.24255000
53MP0003011_delayed_dark_adaptation1.22018742
54MP0003329_amyloid_beta_deposits1.21293391
55MP0000762_abnormal_tongue_morphology1.19986792
56MP0000367_abnormal_coat/_hair1.19511842
57MP0004185_abnormal_adipocyte_glucose1.17561962
58MP0000566_synostosis1.16023518
59MP0002139_abnormal_hepatobiliary_system1.14981698
60MP0000462_abnormal_digestive_system1.10275214
61MP0004858_abnormal_nervous_system1.05603782
62MP0009643_abnormal_urine_homeostasis1.03143672
63MP0001533_abnormal_skeleton_physiology1.01734384
64MP0000627_abnormal_mammary_gland0.98002407
65MP0004043_abnormal_pH_regulation0.96564405
66MP0001851_eye_inflammation0.96296733
67MP0001664_abnormal_digestion0.95110697
68MP0010352_gastrointestinal_tract_polyps0.94383346
69MP0009840_abnormal_foam_cell0.93129145
70MP0005076_abnormal_cell_differentiation0.91740935
71MP0005636_abnormal_mineral_homeostasis0.91215986
72MP0005187_abnormal_penis_morphology0.90214051
73MP0000477_abnormal_intestine_morphology0.86028970
74MP0002095_abnormal_skin_pigmentation0.84995976
75MP0000604_amyloidosis0.84122185
76MP0001784_abnormal_fluid_regulation0.83811512
77MP0001243_abnormal_dermal_layer0.83437409
78MP0005025_abnormal_response_to0.82582051
79MP0000467_abnormal_esophagus_morphology0.78359741
80MP0009931_abnormal_skin_appearance0.77505210
81MP0000377_abnormal_hair_follicle0.76622407
82MP0002234_abnormal_pharynx_morphology0.76126981
83MP0004808_abnormal_hematopoietic_stem0.72611098
84MP0003950_abnormal_plasma_membrane0.72025109
85MP0003936_abnormal_reproductive_system0.69362390
86MP0005360_urolithiasis0.65872730
87MP0003115_abnormal_respiratory_system0.64383759
88MP0008872_abnormal_physiological_respon0.63852789
89MP0000249_abnormal_blood_vessel0.63211886
90MP0010155_abnormal_intestine_physiology0.62964122
91MP0002419_abnormal_innate_immunity0.61265730
92MP0003448_altered_tumor_morphology0.60882380
93MP0001501_abnormal_sleep_pattern0.60567384
94MP0002998_abnormal_bone_remodeling0.59315474
95MP0003300_gastrointestinal_ulcer0.59021334
96MP0000685_abnormal_immune_system0.58867562
97MP0004484_altered_response_of0.58372310
98MP0003315_abnormal_perineum_morphology0.57984977
99MP0001756_abnormal_urination0.57977134
100MP0005390_skeleton_phenotype0.57961668
101MP0000343_altered_response_to0.54572243
102MP0005381_digestive/alimentary_phenotyp0.53275828
103MP0002168_other_aberrant_phenotype0.53078479
104MP0005165_increased_susceptibility_to0.53049059
105MP0002136_abnormal_kidney_physiology0.52995917
106MP0005023_abnormal_wound_healing0.52264556
107MP0005319_abnormal_enzyme/_coenzyme0.50382596
108MP0002295_abnormal_pulmonary_circulatio0.50310556
109MP0006082_CNS_inflammation0.49591241
110MP0001663_abnormal_digestive_system0.49438522
111MP0000609_abnormal_liver_physiology0.46050761
112MP0000647_abnormal_sebaceous_gland0.45899698
113MP0001440_abnormal_grooming_behavior0.45841119
114MP0003638_abnormal_response/metabolism_0.45638360
115MP0005666_abnormal_adipose_tissue0.44803161
116MP0010368_abnormal_lymphatic_system0.44256077
117MP0003690_abnormal_glial_cell0.44088772
118MP0000427_abnormal_hair_cycle0.42396492
119MP0005508_abnormal_skeleton_morphology0.41345357
120MP0002138_abnormal_hepatobiliary_system0.40958063
121MP0008469_abnormal_protein_level0.40821716
122MP0002896_abnormal_bone_mineralization0.39611083
123MP0005375_adipose_tissue_phenotype0.34476243
124MP0009379_abnormal_foot_pigmentation0.34383583
125MP0002177_abnormal_outer_ear0.34368958
126MP0002111_abnormal_tail_morphology0.31482146
127MP0003755_abnormal_palate_morphology0.31392493
128MP0001340_abnormal_eyelid_morphology0.30574947
129MP0004197_abnormal_fetal_growth/weight/0.28499583
130MP0010030_abnormal_orbit_morphology0.25764423
131MP0002133_abnormal_respiratory_system0.25180538
132MP0005388_respiratory_system_phenotype0.25180538
133MP0005503_abnormal_tendon_morphology0.24462320
134MP0003763_abnormal_thymus_physiology0.23805279
135MP0008260_abnormal_autophagy0.23436855
136MP0009333_abnormal_splenocyte_physiolog0.22675368
137MP0001177_atelectasis0.22629776
138MP0000003_abnormal_adipose_tissue0.22387001
139MP0001502_abnormal_circadian_rhythm0.19684216
140MP0005075_abnormal_melanosome_morpholog0.17841112
141MP0000470_abnormal_stomach_morphology0.17478205
142MP0002282_abnormal_trachea_morphology0.16796032
143MP0003828_pulmonary_edema0.15800889
144MP0003724_increased_susceptibility_to0.13160874
145MP0008569_lethality_at_weaning0.13062942
146MP0004510_myositis0.12498678
147MP0009672_abnormal_birth_weight0.11329357
148MP0001186_pigmentation_phenotype0.11215078
149MP0008438_abnormal_cutaneous_collagen0.10518402
150MP0001905_abnormal_dopamine_level0.09686337
151MP0003221_abnormal_cardiomyocyte_apopto0.09600043
152MP0003633_abnormal_nervous_system0.08663688
153MP0008789_abnormal_olfactory_epithelium0.08636221
154MP0002006_tumorigenesis0.07860022
155MP0005193_abnormal_anterior_eye0.07056204
156MP0009765_abnormal_xenobiotic_induced0.06634671
157MP0002877_abnormal_melanocyte_morpholog0.05825618
158MP0005499_abnormal_olfactory_system0.04992816
159MP0005394_taste/olfaction_phenotype0.04992816

Predicted human phenotypes

RankGene SetZ-score
1Congenital sensorineural hearing impairment (HP:0008527)9.15536610
2Congenital nonbullous ichthyosiform erythroderma (HP:0007479)9.13912179
3Increased IgE level (HP:0003212)8.95215185
4Palmar hyperkeratosis (HP:0010765)8.68642490
5Oral leukoplakia (HP:0002745)8.48164536
6Onycholysis (HP:0001806)8.34379933
7Erythroderma (HP:0001019)8.22300870
8Morphological abnormality of the inner ear (HP:0011390)7.25308050
9Parakeratosis (HP:0001036)7.03997471
10Erythema (HP:0010783)6.25610520
11Thick nail (HP:0001805)6.24520872
12Milia (HP:0001056)5.96747981
13Corneal erosion (HP:0200020)5.77561982
14Atrophic scars (HP:0001075)5.76867021
15Fragile nails (HP:0001808)5.54636774
16Pili torti (HP:0003777)5.40056589
17Alopecia of scalp (HP:0002293)5.25258376
18Hyperparathyroidism (HP:0000843)5.04632526
19Gout (HP:0001997)4.98359322
20Hypotrichosis (HP:0001006)4.96464903
21Gangrene (HP:0100758)4.90321961
22Ectropion (HP:0000656)4.84339568
23Abnormality of secondary sexual hair (HP:0009888)4.54278717
24Abnormality of the axillary hair (HP:0100134)4.54278717
25Follicular hyperkeratosis (HP:0007502)4.36178840
26Tracheal stenosis (HP:0002777)4.29035287
27Palmoplantar keratoderma (HP:0000982)4.28794299
28Goiter (HP:0000853)4.13583719
29Plantar hyperkeratosis (HP:0007556)3.97674060
30Curly hair (HP:0002212)3.95098626
31Thyroid carcinoma (HP:0002890)3.89531433
32Abnormal hair laboratory examination (HP:0003328)3.77581022
33Pustule (HP:0200039)3.76868621
34Conjunctival hamartoma (HP:0100780)3.66885412
35Right ventricular cardiomyopathy (HP:0011663)3.66171390
36Split foot (HP:0001839)3.44416099
37Lip pit (HP:0100267)3.38036214
38Complement deficiency (HP:0004431)3.24798872
39Furrowed tongue (HP:0000221)3.23596500
40Glomerulonephritis (HP:0000099)3.18259501
41Absent eyelashes (HP:0000561)3.15871419
42Absent hair (HP:0002298)3.12990090
43Glomerulosclerosis (HP:0000096)3.10532402
44Pruritus (HP:0000989)3.10418682
45Sparse eyelashes (HP:0000653)3.08519961
46Deep venous thrombosis (HP:0002625)3.02003526
47Lack of skin elasticity (HP:0100679)3.01697045
48Nail dystrophy (HP:0008404)2.91863307
49Laryngomalacia (HP:0001601)2.74149039
50Hypoplasia of dental enamel (HP:0006297)2.68581813
51Ankyloglossia (HP:0010296)2.66067696
52Vertigo (HP:0002321)2.63910878
53Abnormality of the salivary glands (HP:0010286)2.60451147
54Hyperuricemia (HP:0002149)2.59918943
55Increased purine levels (HP:0004368)2.59918943
56Paralysis (HP:0003470)2.57969539
57Hemorrhage of the eye (HP:0011885)2.57790230
58Sparse scalp hair (HP:0002209)2.55660997
59Abnormality of complement system (HP:0005339)2.53222909
60Autoamputation (HP:0001218)2.49607893
61Congenital ichthyosiform erythroderma (HP:0007431)2.47907733
62Micronodular cirrhosis (HP:0001413)2.45058290
63Hypergammaglobulinemia (HP:0010702)2.39792153
64Hamartoma of the eye (HP:0010568)2.37764832
65Focal segmental glomerulosclerosis (HP:0000097)2.30086890
66Urticaria (HP:0001025)2.29920628
67Intrahepatic cholestasis (HP:0001406)2.29400519
68Nephritis (HP:0000123)2.24879107
69Multifactorial inheritance (HP:0001426)2.23482861
70Hyperhidrosis (HP:0000975)2.22715679
71Brittle hair (HP:0002299)2.20353490
72Axonal loss (HP:0003447)2.19115557
73Corneal dystrophy (HP:0001131)2.16498165
74Abnormal blistering of the skin (HP:0008066)2.16232728
75Vascular calcification (HP:0004934)2.16160424
76Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.10645468
77Sepsis (HP:0100806)2.07890977
78Interstitial pulmonary disease (HP:0006530)2.07432208
79Fragile skin (HP:0001030)2.06520333
80Abnormality of macular pigmentation (HP:0008002)2.05752141
81Abnormality of oral frenula (HP:0000190)2.03855548
82Cheilitis (HP:0100825)2.03018074
83Cardiovascular calcification (HP:0011915)2.02230707
84Tubulointerstitial fibrosis (HP:0005576)2.00597848
85Abnormality of purine metabolism (HP:0004352)2.00037788
86Abnormality of nail color (HP:0100643)14.6680749
87Abnormality of cochlea (HP:0000375)10.1429871
88Natal tooth (HP:0000695)1.95695758
89Radial bowing (HP:0002986)1.95487676
90Anonychia (HP:0001798)1.94218777
91Recurrent corneal erosions (HP:0000495)1.93749000
92Tubulointerstitial nephritis (HP:0001970)1.93527644
93Keratoconjunctivitis sicca (HP:0001097)1.92699527
94Central scotoma (HP:0000603)1.91502448
95Subacute progressive viral hepatitis (HP:0006572)1.90752069
96Neoplasm of the thyroid gland (HP:0100031)1.89653606
97Blepharitis (HP:0000498)1.89406654
98Fibular aplasia (HP:0002990)1.87418642
99Ridged nail (HP:0001807)1.86549730
100Verrucae (HP:0200043)1.83570414
101Papilloma (HP:0012740)1.83570414
102Renal salt wasting (HP:0000127)1.80201920
103Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.80123090
104Xanthomatosis (HP:0000991)1.79448622
105Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.78459752
106Hydroureter (HP:0000072)1.78207217
107Abnormality of monocarboxylic acid metabolism (HP:0010996)1.77746882
108Carious teeth (HP:0000670)1.77679153
109Esophageal atresia (HP:0002032)1.76921363
110Tubular atrophy (HP:0000092)1.75293758
111Keratoconjunctivitis (HP:0001096)1.75272260
112Bowed forearm bones (HP:0003956)1.73235331
113Bowing of the arm (HP:0006488)1.73235331
114Bronchomalacia (HP:0002780)1.72562591
115Recurrent bacterial skin infections (HP:0005406)1.70794296
116Skin ulcer (HP:0200042)1.68923418
117Advanced eruption of teeth (HP:0006288)1.68603316
118Esophageal varix (HP:0002040)1.67793503
119Ventricular tachycardia (HP:0004756)1.67730555
120Reticulocytosis (HP:0001923)1.67499132
121Dry skin (HP:0000958)1.66143704
122Germ cell neoplasia (HP:0100728)1.65868414
123Abnormality of placental membranes (HP:0011409)1.65239414
124Amniotic constriction ring (HP:0009775)1.65239414
125Systemic lupus erythematosus (HP:0002725)1.63411135
126Abnormality of the gastric mucosa (HP:0004295)1.63221784
127Spastic diplegia (HP:0001264)1.62335117
128Ureteral stenosis (HP:0000071)1.61742679
129Cone-rod dystrophy (HP:0000548)1.60190613
130Vertebral clefting (HP:0008428)1.59148872
131Abnormality of the fingernails (HP:0001231)1.58532331
132Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.57976866
133Abnormality of hair growth rate (HP:0011363)1.54812335
134Slow-growing hair (HP:0002217)1.54812335
135Shallow orbits (HP:0000586)1.54113032
136Hypoplastic toenails (HP:0001800)1.53921351
137Abnormal vertebral ossification (HP:0100569)1.52554469
138Synostosis involving the elbow (HP:0003938)1.52447702
139Humeroradial synostosis (HP:0003041)1.52447702
140Death in infancy (HP:0001522)1.52116276
141Cervical subluxation (HP:0003308)1.50302897
142Melanocytic nevus (HP:0000995)1.48391660
143Aplasia/hypoplasia of the uterus (HP:0008684)1.47674074
144Dehydration (HP:0001944)1.46125723
145Woolly hair (HP:0002224)1.45438791
146Eczematoid dermatitis (HP:0000976)1.45149311
147Abnormality of iron homeostasis (HP:0011031)1.45115847
148Ureteral obstruction (HP:0006000)1.44729983
149Fine hair (HP:0002213)1.44492981
150Abnormality of small intestinal villus morphology (HP:0011472)1.43607868
151Villous atrophy (HP:0011473)1.43607868
152Segmental peripheral demyelination/remyelination (HP:0003481)1.42834030
153Preauricular skin tag (HP:0000384)1.42415128
154Hypohidrosis (HP:0000966)1.42273483
155Hoarse voice (HP:0001609)1.42222879
156Ileus (HP:0002595)1.41836223
157Bicornuate uterus (HP:0000813)1.41823595
158Vacuolated lymphocytes (HP:0001922)1.41389254
159Palmoplantar hyperkeratosis (HP:0000972)1.41245432
160Cerebral inclusion bodies (HP:0100314)1.41201780
161Polycythemia (HP:0001901)1.40675771
162Hypoplastic labia majora (HP:0000059)1.38944259
163Acanthosis nigricans (HP:0000956)1.38906062
164Dry hair (HP:0011359)1.37055755
165Everted lower lip vermilion (HP:0000232)1.29583862
166Abnormality of the labia majora (HP:0012881)1.25727010
167Skin tags (HP:0010609)1.22151798
168Fatigable weakness (HP:0003473)1.20922365
169Abnormality of the neuromuscular junction (HP:0003398)1.20922365
170Popliteal pterygium (HP:0009756)1.19540866
171Selective tooth agenesis (HP:0001592)1.17417184
172Generalized hyperpigmentation (HP:0007440)1.16217018
173Squamous cell carcinoma (HP:0002860)1.15922661
174Acanthocytosis (HP:0001927)1.15864964
175Hamartoma (HP:0010566)1.10140756
176Recurrent skin infections (HP:0001581)1.07229798
177Xerostomia (HP:0000217)1.05040519

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR13.62059156
2STK243.50027642
3MAP3K63.20951988
4MST43.09688123
5SGK4943.00770171
6SGK2233.00770171
7EPHB22.84534272
8MST1R2.75905211
9FRK2.49965336
10IRAK12.05695494
11EPHA211.7333814
12MAPK151.99198226
13MAP3K91.98440175
14PTK61.93515661
15FER1.88152177
16EPHB11.87772496
17LMTK21.80318767
18TSSK61.79987397
19TRIB31.72451741
20PTK21.59438253
21PKN21.54945750
22BMX1.49233449
23NME11.38908618
24RIPK11.31512991
25LATS11.30688708
26IRAK31.29499931
27MAP3K21.28254604
28MAP2K21.28074749
29MET1.20809412
30TBK11.17811919
31SIK11.16653672
32PAK41.14961815
33LRRK21.08262304
34PIM21.00661738
35IRAK40.99710264
36JAK30.99253556
37EEF2K0.98481483
38RPS6KB20.97565472
39MAPKAPK50.96975479
40MAP2K10.95728118
41IRAK20.95687781
42DDR20.94633024
43ZAP700.92775948
44MAPK70.90652783
45KSR20.89843300
46ERN10.89357293
47MAP3K100.87819537
48STK100.86794196
49ERBB20.86488988
50PRPF4B0.86244903
51STK38L0.86064355
52MARK20.85786903
53FGFR40.85489792
54PDGFRB0.82213444
55MAP3K10.79314341
56MAP3K140.76535488
57EPHA30.75351928
58STK380.74363049
59WNK10.72382209
60PRKD20.71260806
61PAK30.71173817
62ERBB40.70614739
63ADRBK10.70070796
64CDK120.68730687
65MAP2K60.68703360
66STK30.67476223
67ALK0.64390904
68MATK0.62967283
69SGK10.61645701
70NLK0.60228641
71MAPKAPK30.59583306
72TYK20.59097022
73TESK10.58612535
74MAP3K30.57646319
75PRKG20.56280216
76MAP3K130.56073834
77TAOK30.55914534
78SRC0.55013120
79KIT0.53916490
80DMPK0.52657780
81SIK30.52605231
82PRKCI0.51738747
83MAPKAPK20.51457920
84BLK0.51115176
85HCK0.50767225
86KSR10.49574788
87TAOK20.48969202
88PAK10.48503985
89TYRO30.46509004
90CDC42BPA0.45909741
91MAP3K80.45550040
92ERBB30.45327840
93EGFR0.44737394
94TAOK10.43931289
95SGK30.43486215
96MAP3K110.43421401
97IKBKE0.42441394
98MAP3K120.42070497
99SGK20.42022113
100HIPK20.40408831
101PDGFRA0.40248748
102FGFR10.39346524
103TRPM70.39232795
104TTN0.38865690
105GSK3A0.36730213
106PAK20.36644095
107MAP3K50.36267483
108CSK0.35010186
109MOS0.34376047
110BCR0.33246264
111NTRK10.31780426
112IKBKB0.31492904
113CDK190.30768636
114ROCK20.30455757
115TGFBR20.30287190
116TESK20.30160043
117PRKD10.28748486
118PKN10.28500711
119FGR0.28444933
120FLT30.28297935
121FYN0.25844186
122TXK0.25481675
123RPS6KA10.25274032
124PBK0.25013550
125CAMK2B0.24636953
126JAK10.24428091
127CSNK1E0.22933806
128MAP3K70.22868274
129CDK60.22808345
130CSNK1A1L0.22682854
131RET0.22658974
132DYRK20.21593429
133PRKAA20.21070600
134CSNK1G30.20435763
135PRKCE0.19707285
136LATS20.19124668
137FGFR30.19123037
138MAPK40.18385456
139ABL20.18369953
140ICK0.18349148
141MTOR0.18237676
142ABL10.18041631
143CDK50.17852916
144PAK60.17319936
145GRK60.16941675
146EPHA40.15719602
147JAK20.15715380
148CAMK2D0.15401322
149RPS6KA20.15155705

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005914.33441044
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.29229889
3Mineral absorption_Homo sapiens_hsa049783.59565998
4Fat digestion and absorption_Homo sapiens_hsa049753.51569477
5Staphylococcus aureus infection_Homo sapiens_hsa051503.47548651
6Ether lipid metabolism_Homo sapiens_hsa005652.43983279
7Ovarian steroidogenesis_Homo sapiens_hsa049132.32147084
8Thyroid hormone synthesis_Homo sapiens_hsa049182.13719009
9Long-term depression_Homo sapiens_hsa047301.88594035
10Complement and coagulation cascades_Homo sapiens_hsa046101.84274142
11Sphingolipid metabolism_Homo sapiens_hsa006001.82966814
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.79565488
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.70030439
14Toxoplasmosis_Homo sapiens_hsa051451.68809744
15ECM-receptor interaction_Homo sapiens_hsa045121.57962091
16Arachidonic acid metabolism_Homo sapiens_hsa005901.57730394
17Tight junction_Homo sapiens_hsa045301.55816256
18Salivary secretion_Homo sapiens_hsa049701.50496269
19Serotonergic synapse_Homo sapiens_hsa047261.49689672
20Small cell lung cancer_Homo sapiens_hsa052221.44968570
21Leishmaniasis_Homo sapiens_hsa051401.42961520
22Amoebiasis_Homo sapiens_hsa051461.40148931
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37476174
24Pertussis_Homo sapiens_hsa051331.34373083
25Pancreatic secretion_Homo sapiens_hsa049721.32498795
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.28917891
27TNF signaling pathway_Homo sapiens_hsa046681.28515171
28Legionellosis_Homo sapiens_hsa051341.26648745
29Choline metabolism in cancer_Homo sapiens_hsa052311.26376803
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.15875442
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14692190
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.14488266
33Circadian rhythm_Homo sapiens_hsa047101.12682407
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09020475
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.05854799
36Salmonella infection_Homo sapiens_hsa051321.05522420
37Hepatitis C_Homo sapiens_hsa051601.05115911
38Bladder cancer_Homo sapiens_hsa052191.05095661
39Histidine metabolism_Homo sapiens_hsa003401.03837363
40Renal cell carcinoma_Homo sapiens_hsa052111.03746668
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03560025
42HIF-1 signaling pathway_Homo sapiens_hsa040661.00052044
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98216286
44Bile secretion_Homo sapiens_hsa049760.97633377
45Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97179476
46Phototransduction_Homo sapiens_hsa047440.96654460
47Proteoglycans in cancer_Homo sapiens_hsa052050.95648931
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94991461
49Platelet activation_Homo sapiens_hsa046110.88094790
50Adherens junction_Homo sapiens_hsa045200.86704976
51Focal adhesion_Homo sapiens_hsa045100.83270621
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.79937482
53Acute myeloid leukemia_Homo sapiens_hsa052210.79094598
54Estrogen signaling pathway_Homo sapiens_hsa049150.75918550
55Nitrogen metabolism_Homo sapiens_hsa009100.74739083
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74655400
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74332836
58Glutamatergic synapse_Homo sapiens_hsa047240.73915987
59Arginine biosynthesis_Homo sapiens_hsa002200.73848406
60Influenza A_Homo sapiens_hsa051640.72836147
61VEGF signaling pathway_Homo sapiens_hsa043700.71723496
62Shigellosis_Homo sapiens_hsa051310.70716151
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.69543536
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.68880823
65Thyroid cancer_Homo sapiens_hsa052160.68429212
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.67633712
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.67546981
68Oxytocin signaling pathway_Homo sapiens_hsa049210.66713668
69Antigen processing and presentation_Homo sapiens_hsa046120.66429821
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66164131
71Renin secretion_Homo sapiens_hsa049240.65591562
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62651216
73Caffeine metabolism_Homo sapiens_hsa002320.62133845
74Fatty acid elongation_Homo sapiens_hsa000620.59966330
75Gastric acid secretion_Homo sapiens_hsa049710.59256142
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58647106
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57985820
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.56773013
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56394840
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56126613
81MAPK signaling pathway_Homo sapiens_hsa040100.55763700
82Osteoclast differentiation_Homo sapiens_hsa043800.54764959
83Malaria_Homo sapiens_hsa051440.54520275
84Phenylalanine metabolism_Homo sapiens_hsa003600.54336098
85Hippo signaling pathway_Homo sapiens_hsa043900.54254793
86GnRH signaling pathway_Homo sapiens_hsa049120.53131247
87ABC transporters_Homo sapiens_hsa020100.52913439
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50967549
89p53 signaling pathway_Homo sapiens_hsa041150.50643044
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48436609
91Vibrio cholerae infection_Homo sapiens_hsa051100.46789225
92Tuberculosis_Homo sapiens_hsa051520.45183511
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44979073
94Dorso-ventral axis formation_Homo sapiens_hsa043200.44645016
95Insulin resistance_Homo sapiens_hsa049310.43965628
96Pentose phosphate pathway_Homo sapiens_hsa000300.43454382
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.43218777
98Starch and sucrose metabolism_Homo sapiens_hsa005000.42458303
99Fructose and mannose metabolism_Homo sapiens_hsa000510.40737235
100Renin-angiotensin system_Homo sapiens_hsa046140.40675513
101Pathways in cancer_Homo sapiens_hsa052000.40178767
102Glioma_Homo sapiens_hsa052140.40140638
103African trypanosomiasis_Homo sapiens_hsa051430.39957069
104Hematopoietic cell lineage_Homo sapiens_hsa046400.38981696
105Endocytosis_Homo sapiens_hsa041440.38722729
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.38576850
107Dilated cardiomyopathy_Homo sapiens_hsa054140.38123724
108Apoptosis_Homo sapiens_hsa042100.36492628
109Galactose metabolism_Homo sapiens_hsa000520.35584072
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.35173982
111Prion diseases_Homo sapiens_hsa050200.34165146
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34041190
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.32951720
114Axon guidance_Homo sapiens_hsa043600.32352613
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32241183
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.31802700
117MicroRNAs in cancer_Homo sapiens_hsa052060.31447984
1182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30554531
119Insulin signaling pathway_Homo sapiens_hsa049100.30055813
120Chronic myeloid leukemia_Homo sapiens_hsa052200.30047373
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29998512
122Long-term potentiation_Homo sapiens_hsa047200.29944290
123Ras signaling pathway_Homo sapiens_hsa040140.28355374
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27608047
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27455311
126Pyruvate metabolism_Homo sapiens_hsa006200.26921942
127Rap1 signaling pathway_Homo sapiens_hsa040150.26883262
128Melanogenesis_Homo sapiens_hsa049160.26846848
129Carbon metabolism_Homo sapiens_hsa012000.26654469
130Biosynthesis of amino acids_Homo sapiens_hsa012300.26421957
131Retinol metabolism_Homo sapiens_hsa008300.26114894
132ErbB signaling pathway_Homo sapiens_hsa040120.25752362
133RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25440619
134PPAR signaling pathway_Homo sapiens_hsa033200.25256158
135Glutathione metabolism_Homo sapiens_hsa004800.24639163
136Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24474664
137Basal cell carcinoma_Homo sapiens_hsa052170.23959487
138Inositol phosphate metabolism_Homo sapiens_hsa005620.21024823
139Pancreatic cancer_Homo sapiens_hsa052120.18183476
140NF-kappa B signaling pathway_Homo sapiens_hsa040640.17707866
141Collecting duct acid secretion_Homo sapiens_hsa049660.15765404
142Rheumatoid arthritis_Homo sapiens_hsa053230.13107942
143Calcium signaling pathway_Homo sapiens_hsa040200.12084476
144Phagosome_Homo sapiens_hsa041450.11255227
145Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.11164182
146Graft-versus-host disease_Homo sapiens_hsa053320.10876777

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