SPRR2D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1molting cycle (GO:0042303)9.30423104
2hair cycle (GO:0042633)9.30423104
3long-chain fatty acid biosynthetic process (GO:0042759)8.75101912
4lipoxygenase pathway (GO:0019372)7.62903133
5establishment of skin barrier (GO:0061436)7.60182086
6citrulline metabolic process (GO:0000052)7.57055054
7epidermal cell differentiation (GO:0009913)7.47472248
8regulation of water loss via skin (GO:0033561)7.31947936
9desmosome organization (GO:0002934)7.31269755
10interferon-gamma secretion (GO:0072643)7.27505294
11* epidermis development (GO:0008544)6.98911425
12linoleic acid metabolic process (GO:0043651)6.92546606
13negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)6.84065799
14maintenance of gastrointestinal epithelium (GO:0030277)6.44139867
15peptidyl-arginine modification (GO:0018195)6.19610062
16lung lobe morphogenesis (GO:0060463)5.84515152
17negative regulation of interleukin-17 production (GO:0032700)5.83772793
18regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)5.77041393
19negative regulation of interferon-gamma production (GO:0032689)5.58649885
20regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)5.57672906
21positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)5.57672906
22skin morphogenesis (GO:0043589)5.54041166
23positive regulation of osteoblast proliferation (GO:0033690)5.49033755
24regulation of natural killer cell differentiation (GO:0032823)5.45655838
25complement activation, alternative pathway (GO:0006957)5.44018755
26phosphatidylserine acyl-chain remodeling (GO:0036150)5.41921188
27phosphatidylinositol acyl-chain remodeling (GO:0036149)5.39287485
28peptide cross-linking (GO:0018149)5.29023482
29epithelial structure maintenance (GO:0010669)5.18302485
30ectoderm development (GO:0007398)5.15038832
31regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033395.10545920
32lung vasculature development (GO:0060426)5.05392304
33phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.89528125
34positive regulation of astrocyte differentiation (GO:0048711)4.86965009
35multicellular organismal water homeostasis (GO:0050891)4.77634528
36regulation of nephron tubule epithelial cell differentiation (GO:0072182)4.76300052
37positive regulation of cellular amide metabolic process (GO:0034250)4.74015594
38intermediate filament organization (GO:0045109)4.58086695
39wound healing, spreading of epidermal cells (GO:0035313)4.52944631
40bundle of His cell to Purkinje myocyte communication (GO:0086069)4.49183990
41positive regulation of monocyte chemotaxis (GO:0090026)4.44335353
42muscle organ morphogenesis (GO:0048644)4.31949188
43antimicrobial humoral response (GO:0019730)4.30684279
44positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)4.24744410
45sulfate transmembrane transport (GO:1902358)4.22186061
46sequestering of metal ion (GO:0051238)4.21303580
47regulation of toll-like receptor 4 signaling pathway (GO:0034143)4.12341303
48positive regulation of p38MAPK cascade (GO:1900745)4.10250107
49tyrosine phosphorylation of STAT protein (GO:0007260)4.09877214
50defense response to Gram-negative bacterium (GO:0050829)4.07533418
51regulation of epithelial cell differentiation involved in kidney development (GO:2000696)4.07438114
52establishment of tissue polarity (GO:0007164)4.03577074
53establishment of planar polarity (GO:0001736)4.03577074
54cell-substrate junction assembly (GO:0007044)4.00451301
55water homeostasis (GO:0030104)3.92950682
56positive regulation of epidermis development (GO:0045684)3.87672930
57phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.83914471
58regulation of transforming growth factor beta1 production (GO:0032908)3.83583750
59phosphatidylserine metabolic process (GO:0006658)3.81401392
60surfactant homeostasis (GO:0043129)3.80018990
61response to host immune response (GO:0052572)3.79336585
62response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.79336585
63keratinocyte development (GO:0003334)3.77280209
64decidualization (GO:0046697)3.71071756
65detection of external biotic stimulus (GO:0098581)3.66781965
66hair cell differentiation (GO:0035315)3.59538142
67positive regulation of T cell chemotaxis (GO:0010820)3.59193885
68regulation of T cell chemotaxis (GO:0010819)3.59193885
69regulation of complement activation (GO:0030449)3.56748660
70negative regulation of cell fate specification (GO:0009996)3.53777138
71fatty acid elongation (GO:0030497)3.52819370
72positive regulation of toll-like receptor signaling pathway (GO:0034123)3.50190262
73response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.49801251
74response to host (GO:0075136)3.49801251
75response to host defenses (GO:0052200)3.49801251
764-hydroxyproline metabolic process (GO:0019471)3.48819546
77eyelid development in camera-type eye (GO:0061029)3.48609648
78detection of bacterium (GO:0016045)3.39962190
79intermediate filament cytoskeleton organization (GO:0045104)3.39335527
80regulation of interleukin-17 production (GO:0032660)3.33604716
81cytoskeletal anchoring at plasma membrane (GO:0007016)3.31199805
82sulfate transport (GO:0008272)3.31027540
83chemical homeostasis within a tissue (GO:0048875)3.30175274
84ceramide biosynthetic process (GO:0046513)3.29546961
85positive regulation of epidermal cell differentiation (GO:0045606)3.28618125
86regulation of protein activation cascade (GO:2000257)3.28437109
87intermediate filament-based process (GO:0045103)3.26084449
88wound healing, spreading of cells (GO:0044319)3.24028512
89* epithelium development (GO:0060429)3.23959780
90peptidyl-proline hydroxylation (GO:0019511)3.20747077
91defense response to fungus (GO:0050832)3.18924202
92phosphatidylcholine acyl-chain remodeling (GO:0036151)3.18588760
93regulation of monocyte chemotaxis (GO:0090025)3.17922850
94planar cell polarity pathway involved in neural tube closure (GO:0090179)3.14441411
95apical protein localization (GO:0045176)3.11298140
96regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.09829718
97regulation of p38MAPK cascade (GO:1900744)3.09660807
98detection of biotic stimulus (GO:0009595)3.08533276
99detection of other organism (GO:0098543)2.96892722
100regulation of natural killer cell activation (GO:0032814)2.96456668
101positive regulation of glomerulus development (GO:0090193)2.96353609
102response to fungus (GO:0009620)2.95965899
103regulation of cholesterol homeostasis (GO:2000188)2.93786720
104keratinocyte proliferation (GO:0043616)2.91098436
105intestinal epithelial cell development (GO:0060576)2.90111584
106positive regulation of metanephros development (GO:0072216)2.90070302
107regulation of neuron projection regeneration (GO:0070570)2.89374372
108regulation of axon regeneration (GO:0048679)2.89374372
109regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.89071339
110alditol phosphate metabolic process (GO:0052646)2.87791444
111negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.87459052
112trophoblast giant cell differentiation (GO:0060707)2.81550169
113regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.81521608
114low-density lipoprotein particle clearance (GO:0034383)2.80511914
115positive regulation of interleukin-8 secretion (GO:2000484)2.80076310
116positive regulation of keratinocyte differentiation (GO:0045618)2.78713859
117positive regulation of macrophage differentiation (GO:0045651)2.76406440
118regulation of apoptotic cell clearance (GO:2000425)2.75042950
119hair follicle morphogenesis (GO:0031069)2.74056529
120regulation of epidermis development (GO:0045682)2.73655197
121branching involved in salivary gland morphogenesis (GO:0060445)2.71156927
122O-glycan processing (GO:0016266)2.70356807
123long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.70025489
124positive regulation of humoral immune response (GO:0002922)2.69808459
125negative regulation of bone mineralization (GO:0030502)2.65353112
126phosphatidylglycerol metabolic process (GO:0046471)2.61800366
127positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.61098790
128regulation of keratinocyte differentiation (GO:0045616)2.61075093
129positive regulation of histone acetylation (GO:0035066)2.60446064
130response to UV-B (GO:0010224)2.59749751
131negative regulation of cytokine-mediated signaling pathway (GO:0001960)2.58858535
132gap junction assembly (GO:0016264)2.58634060
133phospholipid catabolic process (GO:0009395)2.55734093
134myotube differentiation (GO:0014902)2.55526202
135regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.55019092
136negative regulation of response to cytokine stimulus (GO:0060761)2.54494858
137regulation of osteoblast proliferation (GO:0033688)2.53817504
138ventricular cardiac muscle cell action potential (GO:0086005)2.51141832
139negative regulation of keratinocyte proliferation (GO:0010839)2.47468663
140regulation of T cell migration (GO:2000404)2.47155009
141regulation of hair cycle (GO:0042634)2.47035535
142phosphatidic acid metabolic process (GO:0046473)2.45040765
143phosphatidic acid biosynthetic process (GO:0006654)2.45040765
144regulation of ruffle assembly (GO:1900027)2.44537553
145positive regulation of granulocyte chemotaxis (GO:0071624)2.42991183
146cellular response to arsenic-containing substance (GO:0071243)2.40347215
147protein hydroxylation (GO:0018126)2.39079979
148negative regulation of homotypic cell-cell adhesion (GO:0034111)2.39041244
149positive regulation of cholesterol efflux (GO:0010875)2.38644881
150positive regulation of peptidyl-lysine acetylation (GO:2000758)2.38337817
151positive regulation of protein acetylation (GO:1901985)2.38337817
152cell differentiation involved in embryonic placenta development (GO:0060706)2.35668451
153innate immune response in mucosa (GO:0002227)2.34206090
154negative regulation of biomineral tissue development (GO:0070168)2.33531755
155epithelial cell differentiation (GO:0030855)2.33387196
156antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.32519232
157asymmetric protein localization (GO:0008105)2.32192089
158regulation of cell proliferation involved in kidney development (GO:1901722)2.31016966
159defense response to Gram-positive bacterium (GO:0050830)2.29204480
160phospholipid efflux (GO:0033700)2.28820480
161* keratinization (GO:0031424)18.2593335
162citrulline biosynthetic process (GO:0019240)11.5461830
163keratinocyte differentiation (GO:0030216)10.2818846
164hemidesmosome assembly (GO:0031581)10.0124384

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.23787397
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.60655799
3ESR1_15608294_ChIP-ChIP_MCF-7_Human3.11439882
4ESR1_21235772_ChIP-Seq_MCF-7_Human2.95799855
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.91213545
6ESR2_21235772_ChIP-Seq_MCF-7_Human2.62725338
7ZNF263_19887448_ChIP-Seq_K562_Human2.37202495
8HIF1A_21447827_ChIP-Seq_MCF-7_Human2.29054289
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.14013960
10P63_26484246_Chip-Seq_KERATINOCYTES_Human2.10795024
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.06043962
12TP63_17297297_ChIP-ChIP_HaCaT_Human11.0615058
13SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.99046500
14SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.99046500
15EGR1_19032775_ChIP-ChIP_M12_Human1.98980626
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.93770948
17KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.88505316
18SOX2_20726797_ChIP-Seq_SW620_Human1.86913221
19IKZF1_21737484_ChIP-ChIP_HCT116_Human1.75513270
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.74810145
21FOXO3_23340844_ChIP-Seq_DLD1_Human1.74006388
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.73946934
23ATF3_27146783_Chip-Seq_COLON_Human1.66943034
24CDX2_20551321_ChIP-Seq_CACO-2_Human1.66307044
25RACK7_27058665_Chip-Seq_MCF-7_Human1.65248070
26TCF4_18268006_ChIP-ChIP_LS174T_Human1.63209329
27CLOCK_20551151_ChIP-Seq_293T_Human1.62881575
28KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.60503430
29PPAR_26484153_Chip-Seq_NCI-H1993_Human1.52716021
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51106017
31SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.49563312
32ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.46857075
33LXR_22292898_ChIP-Seq_THP-1_Human1.46476323
34ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.44661220
35SOX9_24532713_ChIP-Seq_HFSC_Mouse1.43839345
36* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.42906207
37ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42713504
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34325739
39RUNX1_27514584_Chip-Seq_MCF-7_Human1.32376110
40SOX2_27498859_Chip-Seq_STOMACH_Mouse1.30377208
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27270621
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.26615297
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.24588307
44KLF5_25053715_ChIP-Seq_YYC3_Human1.24179810
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20106597
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.18440310
47AHR_22903824_ChIP-Seq_MCF-7_Human1.18400217
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14593729
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.14476623
50GATA6_25053715_ChIP-Seq_YYC3_Human1.14054546
51FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.13869773
52GATA4_25053715_ChIP-Seq_YYC3_Human1.13604745
53FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.13489242
54TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13335019
55GATA3_24758297_ChIP-Seq_MCF-7_Human1.13242167
56SCL_19346495_ChIP-Seq_HPC-7_Human1.12772686
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12086096
58MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11591315
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11233849
60KDM2B_26808549_Chip-Seq_K562_Human1.08963534
61FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.08497012
62ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.08237646
63* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.07964282
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06640309
65BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03676543
66ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03040293
67E2F1_20622854_ChIP-Seq_HELA_Human1.01530364
68PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00648725
69RXR_22158963_ChIP-Seq_LIVER_Mouse1.00402047
70CTCF_27219007_Chip-Seq_Bcells_Human1.00022976
71ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98973512
72TP63_23658742_ChIP-Seq_EP156T_Human0.98497395
73UBF1/2_26484160_Chip-Seq_HMECs_Human0.98255712
74TP63_22573176_ChIP-Seq_HFKS_Human0.97301412
75RBPJ_21746931_ChIP-Seq_IB4_Human0.96826009
76P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95587976
77FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95242585
78BCL6_27268052_Chip-Seq_Bcells_Human0.93996631
79RXR_22108803_ChIP-Seq_LS180_Human0.93791631
80SMC4_20622854_ChIP-Seq_HELA_Human0.93509071
81GATA1_19941826_ChIP-Seq_K562_Human0.92365275
82CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.92188711
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91632182
84GATA2_19941826_ChIP-Seq_K562_Human0.90950524
85LXR_22158963_ChIP-Seq_LIVER_Mouse0.90336196
86JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90073848
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87703795
88* ERG_20517297_ChIP-Seq_VCAP_Human0.87327226
89* GATA6_21074721_ChIP-Seq_CACO-2_Human0.86181393
90SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.86045894
91CJUN_26792858_Chip-Seq_BT549_Human0.85507478
92SA1_27219007_Chip-Seq_ERYTHROID_Human0.84956042
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.83990257
94ARNT_22903824_ChIP-Seq_MCF-7_Human0.83919287
95KDM2B_26808549_Chip-Seq_DND41_Human0.83843552
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.83601331
97P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.83476922
98RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82433465
99TP53_18474530_ChIP-ChIP_U2OS_Human0.82373513
100GATA2_21666600_ChIP-Seq_HMVEC_Human0.82200575
101JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81865336
102AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81602433
103VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.81381956
104GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.81204741
105P53_21459846_ChIP-Seq_SAOS-2_Human0.81102248
106SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.80826053
107CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.79625516
108BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.79587756
109SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.79357428
110SUZ12_27294783_Chip-Seq_ESCs_Mouse0.78786433
111HTT_18923047_ChIP-ChIP_STHdh_Human0.78472226
112JARID2_20075857_ChIP-Seq_MESCs_Mouse0.77814181
113MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.77591249
114YY1_22570637_ChIP-Seq_MALME-3M_Human0.77063547
115CSB_26484114_Chip-Seq_FIBROBLAST_Human0.76922256
116* CTCF_20526341_ChIP-Seq_ESCs_Human0.76497776
117CEBPB_22108803_ChIP-Seq_LS180_Human0.76319026
118TCF7_22412390_ChIP-Seq_EML_Mouse0.76268702
119BCOR_27268052_Chip-Seq_Bcells_Human0.76141790
120HNFA_21074721_ChIP-Seq_CACO-2_Human0.74180325
121FOXA1_25552417_ChIP-Seq_VCAP_Human0.71531321
122EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.70247617
123PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.70039772
124VDR_22108803_ChIP-Seq_LS180_Human0.67636050
125SA1_27219007_Chip-Seq_Bcells_Human0.66440594
126Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.65648858
127FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.63628596
128TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.63500232
129THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.62747403
130NANOG_20526341_ChIP-Seq_ESCs_Human0.62338944
131CTNNB1_20460455_ChIP-Seq_HCT116_Human0.62123026

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.10567872
2MP0010234_abnormal_vibrissa_follicle6.81208790
3MP0000579_abnormal_nail_morphology6.07272602
4MP0005275_abnormal_skin_tensile4.74863598
5MP0005501_abnormal_skin_physiology4.39722484
6MP0010678_abnormal_skin_adnexa3.63316983
7MP0004885_abnormal_endolymph3.36883767
8MP0000467_abnormal_esophagus_morphology3.28736595
9MP0000383_abnormal_hair_follicle3.11413817
10MP0001216_abnormal_epidermal_layer3.07664693
11MP0003705_abnormal_hypodermis_morpholog3.05789148
12MP0003453_abnormal_keratinocyte_physiol2.87117403
13MP0010771_integument_phenotype2.69602245
14MP0002060_abnormal_skin_morphology2.63342097
15MP0004947_skin_inflammation2.59951789
16MP0000762_abnormal_tongue_morphology2.39507400
17MP0005377_hearing/vestibular/ear_phenot2.29266386
18MP0003878_abnormal_ear_physiology2.29266386
19MP0002098_abnormal_vibrissa_morphology2.27081118
20MP0002254_reproductive_system_inflammat2.15763278
21MP0004381_abnormal_hair_follicle2.14790268
22MP0003566_abnormal_cell_adhesion1.99509069
23MP0004043_abnormal_pH_regulation1.96270190
24MP0000377_abnormal_hair_follicle1.95899921
25MP0005083_abnormal_biliary_tract1.85759876
26MP0003436_decreased_susceptibility_to1.78552828
27MP0000647_abnormal_sebaceous_gland1.77819004
28MP0001849_ear_inflammation1.67926912
29MP0004264_abnormal_extraembryonic_tissu1.66706458
30MP0009931_abnormal_skin_appearance1.48239550
31MP0000427_abnormal_hair_cycle1.46060534
32MP0009053_abnormal_anal_canal1.43886311
33MP0004185_abnormal_adipocyte_glucose1.41658325
34MP0002234_abnormal_pharynx_morphology1.40365839
35MP0003191_abnormal_cellular_cholesterol1.39808686
36MP0005409_darkened_coat_color1.33800345
37MP0003866_abnormal_defecation1.30821438
38MP0003941_abnormal_skin_development1.27334513
39MP0000537_abnormal_urethra_morphology1.26038303
40MP0001188_hyperpigmentation1.22189586
41MP0000367_abnormal_coat/_hair1.11065610
42MP0006054_spinal_hemorrhage1.10991945
43MP0001666_abnormal_nutrient_absorption1.10514930
44MP0001191_abnormal_skin_condition1.09587636
45MP0003303_peritoneal_inflammation1.09182107
46MP0005023_abnormal_wound_healing1.08731331
47MP0004019_abnormal_vitamin_homeostasis1.02793505
48MP0008438_abnormal_cutaneous_collagen1.01575991
49MP0002909_abnormal_adrenal_gland0.95127011
50MP0009785_altered_susceptibility_to0.94795305
51MP0008004_abnormal_stomach_pH0.93195194
52MP0004742_abnormal_vestibular_system0.93133122
53MP0005451_abnormal_body_composition0.92764770
54MP0001851_eye_inflammation0.91231254
55MP0004272_abnormal_basement_membrane0.91103073
56MP0002095_abnormal_skin_pigmentation0.90835402
57MP0003045_fibrosis0.90610176
58MP0000465_gastrointestinal_hemorrhage0.89992989
59MP0010352_gastrointestinal_tract_polyps0.89934890
60MP0001765_abnormal_ion_homeostasis0.86818240
61MP0001243_abnormal_dermal_layer0.86593214
62MP0001485_abnormal_pinna_reflex0.85243810
63MP0003075_altered_response_to0.84286534
64MP0003011_delayed_dark_adaptation0.80918625
65MP0005166_decreased_susceptibility_to0.79321683
66MP0000627_abnormal_mammary_gland0.73799991
67MP0005085_abnormal_gallbladder_physiolo0.72974714
68MP0003329_amyloid_beta_deposits0.72958994
69MP0001533_abnormal_skeleton_physiology0.71978555
70MP0005310_abnormal_salivary_gland0.62331509
71MP0001727_abnormal_embryo_implantation0.60663003
72MP0004858_abnormal_nervous_system0.59064627
73MP0005375_adipose_tissue_phenotype0.58692703
74MP0001881_abnormal_mammary_gland0.58550579
75MP0002282_abnormal_trachea_morphology0.56436611
76MP0000604_amyloidosis0.52625118
77MP0009333_abnormal_splenocyte_physiolog0.52408400
78MP0005076_abnormal_cell_differentiation0.51767202
79MP0000462_abnormal_digestive_system0.51752219
80MP0003448_altered_tumor_morphology0.51499366
81MP0004782_abnormal_surfactant_physiolog0.51316888
82MP0005025_abnormal_response_to0.51037060
83MP0001340_abnormal_eyelid_morphology0.49981451
84MP0003315_abnormal_perineum_morphology0.49750847
85MP0009780_abnormal_chondrocyte_physiolo0.49106515
86MP0001784_abnormal_fluid_regulation0.47521896
87MP0005503_abnormal_tendon_morphology0.47452651
88MP0009840_abnormal_foam_cell0.46750155
89MP0003300_gastrointestinal_ulcer0.46161715
90MP0003755_abnormal_palate_morphology0.45428187
91MP0005666_abnormal_adipose_tissue0.44940278
92MP0010368_abnormal_lymphatic_system0.44156605
93MP0000477_abnormal_intestine_morphology0.41573153
94MP0000678_abnormal_parathyroid_gland0.40473742
95MP0000343_altered_response_to0.40169496
96MP0010030_abnormal_orbit_morphology0.38760193
97MP0005390_skeleton_phenotype0.38112053
98MP0000470_abnormal_stomach_morphology0.37043496
99MP0000003_abnormal_adipose_tissue0.36621844
100MP0003828_pulmonary_edema0.35546605
101MP0001502_abnormal_circadian_rhythm0.35275143
102MP0008789_abnormal_olfactory_epithelium0.34661390
103MP0004197_abnormal_fetal_growth/weight/0.33167488
104MP0000566_synostosis0.32893265
105MP0002138_abnormal_hepatobiliary_system0.32537427
106MP0009643_abnormal_urine_homeostasis0.32397017
107MP0002998_abnormal_bone_remodeling0.32226585
108MP0001958_emphysema0.31913814
109MP0002111_abnormal_tail_morphology0.31408823
110MP0010155_abnormal_intestine_physiology0.30423369
111MP0002006_tumorigenesis0.29504917
112MP0003950_abnormal_plasma_membrane0.29423148
113MP0005636_abnormal_mineral_homeostasis0.29197417
114MP0000685_abnormal_immune_system0.29158285
115MP0003115_abnormal_respiratory_system0.28914137
116MP0002419_abnormal_innate_immunity0.28776860
117MP0000750_abnormal_muscle_regeneration0.27703725
118MP0000733_abnormal_muscle_development0.27331075
119MP0009672_abnormal_birth_weight0.27254961
120MP0009379_abnormal_foot_pigmentation0.26260087
121MP0002177_abnormal_outer_ear0.24901125
122MP0002877_abnormal_melanocyte_morpholog0.24859284
123MP0005388_respiratory_system_phenotype0.18632571
124MP0002133_abnormal_respiratory_system0.18632571
125MP0003221_abnormal_cardiomyocyte_apopto0.17900010
126MP0003638_abnormal_response/metabolism_0.17142096
127MP0009115_abnormal_fat_cell0.16639321
128MP0001186_pigmentation_phenotype0.16481485
129MP0005193_abnormal_anterior_eye0.16368642
130MP0002136_abnormal_kidney_physiology0.15630057
131MP0008260_abnormal_autophagy0.13498508
132MP0005075_abnormal_melanosome_morpholog0.10902595
133MP0000371_diluted_coat_color0.09892201
134MP0001177_atelectasis0.09588856
135MP0002249_abnormal_larynx_morphology0.08820154
136MP0001756_abnormal_urination0.08130829
137MP0002075_abnormal_coat/hair_pigmentati0.07598162
138MP0008569_lethality_at_weaning0.06226962
139MP0003806_abnormal_nucleotide_metabolis0.05877555
140MP0002166_altered_tumor_susceptibility0.05783057
141MP0002081_perinatal_lethality0.05499948

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)8.35307107
2Thick nail (HP:0001805)8.28342665
3Alopecia of scalp (HP:0002293)8.08394620
4Plantar hyperkeratosis (HP:0007556)7.35399356
5Milia (HP:0001056)6.63605452
6Oral leukoplakia (HP:0002745)6.55422751
7Palmoplantar hyperkeratosis (HP:0000972)6.53939857
8Fragile nails (HP:0001808)6.45320492
9Palmar hyperkeratosis (HP:0010765)6.15567405
10Pili torti (HP:0003777)5.39759373
11Follicular hyperkeratosis (HP:0007502)5.16608065
12Abnormality of cochlea (HP:0000375)5.00645413
13Abnormal blistering of the skin (HP:0008066)4.76737012
14Increased IgE level (HP:0003212)4.70963109
15Congenital sensorineural hearing impairment (HP:0008527)4.70670589
16Atrophic scars (HP:0001075)4.55206853
17Right ventricular cardiomyopathy (HP:0011663)4.41917940
18Nail dystrophy (HP:0008404)4.32269156
19Abnormality of the axillary hair (HP:0100134)4.21717633
20Abnormality of secondary sexual hair (HP:0009888)4.21717633
21Woolly hair (HP:0002224)4.12954910
22Hypotrichosis (HP:0001006)4.05482998
23Congenital ichthyosiform erythroderma (HP:0007431)3.80965356
24Abnormal hair laboratory examination (HP:0003328)3.63841065
25Ridged nail (HP:0001807)3.60133439
26Laryngomalacia (HP:0001601)3.48994088
27Morphological abnormality of the inner ear (HP:0011390)3.48662052
28Curly hair (HP:0002212)3.35235675
29Sparse scalp hair (HP:0002209)3.33137662
30Furrowed tongue (HP:0000221)3.18874786
31Erythroderma (HP:0001019)3.15302026
32Erythema (HP:0010783)3.03983532
33Anonychia (HP:0001798)3.00856022
34Absent hair (HP:0002298)2.92102637
35Brittle hair (HP:0002299)2.87215414
36Corneal dystrophy (HP:0001131)2.74923884
37Hypohidrosis (HP:0000966)2.73804775
38Palmoplantar keratoderma (HP:0000982)2.72864342
39Corneal erosion (HP:0200020)2.63300103
40Hyperhidrosis (HP:0000975)2.55505440
41Hyperparathyroidism (HP:0000843)2.53403055
42Abnormality of small intestinal villus morphology (HP:0011472)2.53104362
43Villous atrophy (HP:0011473)2.53104362
44Gout (HP:0001997)2.49020531
45Conjunctival hamartoma (HP:0100780)2.44502350
46Fatigable weakness (HP:0003473)2.23273094
47Abnormality of the neuromuscular junction (HP:0003398)2.23273094
48Lip pit (HP:0100267)2.16994328
49Pustule (HP:0200039)2.14613259
50Blepharitis (HP:0000498)2.13388215
51Ectropion (HP:0000656)2.13353581
52Gangrene (HP:0100758)2.11361034
53Carious teeth (HP:0000670)2.07882972
54Complement deficiency (HP:0004431)2.07244713
55Ventricular tachycardia (HP:0004756)2.06931897
56Fragile skin (HP:0001030)2.05917673
57Acanthosis nigricans (HP:0000956)2.03761804
58Multifactorial inheritance (HP:0001426)2.01665300
59Tracheal stenosis (HP:0002777)2.01254881
60Paralysis (HP:0003470)2.00560727
61Abnormality of nail color (HP:0100643)12.4590544
62Advanced eruption of teeth (HP:0006288)1.99005417
63Abnormality of the fingernails (HP:0001231)1.97587952
64Parakeratosis (HP:0001036)1.92534140
65Verrucae (HP:0200043)1.90732439
66Papilloma (HP:0012740)1.90732439
67Hypoplasia of dental enamel (HP:0006297)1.87705551
68Abnormality of placental membranes (HP:0011409)1.86553143
69Amniotic constriction ring (HP:0009775)1.86553143
70Skin ulcer (HP:0200042)1.83482410
71Hypoplastic labia majora (HP:0000059)1.82859486
72Glomerulonephritis (HP:0000099)1.82076481
73Eczematoid dermatitis (HP:0000976)1.82067430
74Split foot (HP:0001839)1.77727704
75Vertigo (HP:0002321)1.77565421
76Neonatal onset (HP:0003623)1.77214788
77Sepsis (HP:0100806)1.77049883
78Thyroid carcinoma (HP:0002890)1.75401301
79Dry skin (HP:0000958)1.74280152
80Hyperactive renin-angiotensin system (HP:0000841)1.73285678
81Abnormality of complement system (HP:0005339)1.72296754
82Increased connective tissue (HP:0009025)1.71031238
83Fine hair (HP:0002213)1.68686518
84Absent eyelashes (HP:0000561)1.68563228
85Keratoconjunctivitis sicca (HP:0001097)1.66351676
86Abnormality of the labia majora (HP:0012881)1.65101436
87Melanocytic nevus (HP:0000995)1.62943529
88Hyporeflexia of lower limbs (HP:0002600)1.61900364
89Sparse eyelashes (HP:0000653)1.60473546
90Natal tooth (HP:0000695)1.59805368
91Popliteal pterygium (HP:0009756)1.59744765
92Pruritus (HP:0000989)1.57871625
93Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.57824760
94Hypergammaglobulinemia (HP:0010702)1.57285585
95Muscle fiber splitting (HP:0003555)1.56203645
96Deep venous thrombosis (HP:0002625)1.55569212
97Abnormality of hair growth rate (HP:0011363)1.54147907
98Slow-growing hair (HP:0002217)1.54147907
99Glomerulosclerosis (HP:0000096)1.53879178
100Abnormality of the salivary glands (HP:0010286)1.53687125
101Oligodontia (HP:0000677)1.52989886
102Systemic lupus erythematosus (HP:0002725)1.52638539
103Goiter (HP:0000853)1.51164749
104Type 1 muscle fiber predominance (HP:0003803)1.50427375
105Hyperkalemia (HP:0002153)1.49971287
106Lack of skin elasticity (HP:0100679)1.49801501
107Interstitial pulmonary disease (HP:0006530)1.48794383
108Hamartoma of the eye (HP:0010568)1.46411703
109Dehydration (HP:0001944)1.45532027
110Keratoconjunctivitis (HP:0001096)1.45304808
111Distal lower limb muscle weakness (HP:0009053)1.42802953
112Hypoplastic toenails (HP:0001800)1.42179766
113Round ear (HP:0100830)1.41913347
114Axonal loss (HP:0003447)1.41225849
115Recurrent corneal erosions (HP:0000495)1.41220663
116Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.40987930
117Abnormality of the gastric mucosa (HP:0004295)1.40742676
118Urticaria (HP:0001025)1.40424823
119Autoamputation (HP:0001218)1.39733782
120Premature rupture of membranes (HP:0001788)1.39057736
121Aplasia cutis congenita (HP:0001057)1.38498578
122Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.38293754
123Hemorrhage of the eye (HP:0011885)1.35995487
124Nephritis (HP:0000123)1.35854197
125Peritonitis (HP:0002586)1.34613414
126Ankyloglossia (HP:0010296)1.34451807
127Muscle fiber inclusion bodies (HP:0100299)1.32808140
128Dry hair (HP:0011359)1.32647795
129Amelogenesis imperfecta (HP:0000705)1.31771067
130Skin pits (HP:0100276)1.28201662
131Preauricular skin tag (HP:0000384)1.27193146
132Recurrent bacterial skin infections (HP:0005406)1.24704391
133Labial hypoplasia (HP:0000066)1.23196768
134Seborrheic dermatitis (HP:0001051)1.16659768
135Segmental peripheral demyelination/remyelination (HP:0003481)1.16188739
136Everted lower lip vermilion (HP:0000232)1.16077642

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FER3.17155323
2MST1R2.93454755
3EPHB22.63549410
4ERN12.56210069
5MAP3K62.54540349
6TGFBR12.37103700
7EPHB12.34195306
8MST42.32122605
9SGK4942.22527482
10SGK2232.22527482
11TRIB32.12997984
12MAP3K92.09568446
13EPHA210.4347522
14PTK61.76830465
15WNK11.70999897
16IRAK11.67170878
17NME11.66003611
18PKN21.54682543
19RIPK11.53949334
20FRK1.53615928
21MAPKAPK31.53570259
22PTK21.53473911
23MAPK151.41260907
24MAP3K21.40991925
25TSSK61.39425726
26EPHA31.37227819
27BMX1.34558347
28FGFR41.34172061
29MAP3K31.22413684
30MET1.19894327
31LMTK21.17631599
32TBK11.17252981
33MAP3K11.15111919
34IRAK21.14404150
35MAP2K61.12380357
36IRAK41.10732403
37DDR21.09139326
38MARK21.07851044
39SGK31.07529294
40TYK21.05960024
41LRRK21.04268746
42BLK1.04057748
43STK38L1.02758563
44RPS6KB21.01140095
45TTN1.00780759
46SGK20.98867555
47MAPKAPK50.97428861
48PAK40.96103049
49CDK120.95827190
50TGFBR20.95780990
51MAP2K10.95208942
52CAMK1D0.93801516
53TAOK10.92405131
54EEF2K0.92398769
55STK30.92364618
56TESK10.91462232
57RPS6KA40.90296926
58GRK60.89939706
59ZAP700.86849519
60MAP2K20.83513586
61LATS10.82935774
62SIK10.81435228
63IRAK30.81235955
64FGFR30.76651089
65KSR20.76474484
66IKBKB0.75960180
67PIK3CG0.74262371
68PDGFRB0.73993844
69FGFR10.72965447
70PIM20.72942831
71ERBB20.70738485
72STK380.68255242
73MAP3K100.66702550
74CAMK1G0.66414894
75ALK0.65369163
76MAP3K110.64567865
77LATS20.64485604
78MAP3K140.63636603
79STK100.63363026
80MTOR0.60587009
81PDGFRA0.60018504
82IKBKE0.59704989
83MAPK70.57876418
84PRPF4B0.57820490
85MATK0.57026855
86SIK30.55789368
87AKT30.55003861
88JAK10.54050541
89TRPM70.53779841
90STK240.51492326
91SRC0.50468765
92SGK10.49627108
93MOS0.49067586
94MAP3K120.47967810
95PRKD20.47009659
96FGR0.46077840
97CSK0.46070606
98PAK30.46064228
99ERBB40.44117554
100ADRBK10.43709435
101PRKCI0.43195542
102EGFR0.40994535
103LIMK10.40241957
104TYRO30.40237075
105PAK20.40149151
106MAP3K80.39831829
107RPS6KB10.37643375
108PRKAA20.37202962
109RET0.37111906
110MAPKAPK20.36977521
111PRKD10.36695105
112GSK3A0.36573359
113RPS6KA10.34643579
114MAP3K70.32731162
115KSR10.31871906
116PRKG20.31677709
117MAP3K50.31464667
118CDK60.31239847
119FYN0.31128550
120HIPK20.30876148
121CHUK0.30793960
122ERBB30.28569675
123JAK20.27976261
124PKN10.27209233
125ABL20.27055006
126PAK10.27000143
127DYRK30.26824727
128MAP3K130.25624766
129HCK0.25519153
130ROCK20.25303747
131STK390.24858690
132MAPK40.24600952
133WNK40.24556945
134DMPK0.23704405
135BCR0.23625387
136MAP2K40.23311766
137CDC42BPA0.22999808
138TAOK30.22614408
139AKT20.22283525
140MAP2K30.20718850
141ILK0.17516851
142JAK30.16914924
143CSNK1E0.16075472

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005914.55427564
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.51245429
3Staphylococcus aureus infection_Homo sapiens_hsa051503.40820517
4Fat digestion and absorption_Homo sapiens_hsa049753.18259476
5Mineral absorption_Homo sapiens_hsa049782.74590792
6Ether lipid metabolism_Homo sapiens_hsa005652.59219951
7Circadian rhythm_Homo sapiens_hsa047102.23315978
8Arachidonic acid metabolism_Homo sapiens_hsa005901.99148576
9Sphingolipid metabolism_Homo sapiens_hsa006001.95399268
10Ovarian steroidogenesis_Homo sapiens_hsa049131.90243898
11ECM-receptor interaction_Homo sapiens_hsa045121.79368428
12Toxoplasmosis_Homo sapiens_hsa051451.69786174
13Complement and coagulation cascades_Homo sapiens_hsa046101.59805132
14Amoebiasis_Homo sapiens_hsa051461.54022398
15Pertussis_Homo sapiens_hsa051331.46867615
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.45078238
17Serotonergic synapse_Homo sapiens_hsa047261.38242206
18Fatty acid elongation_Homo sapiens_hsa000621.37496639
19Tight junction_Homo sapiens_hsa045301.34733090
20Leishmaniasis_Homo sapiens_hsa051401.31339545
21Leukocyte transendothelial migration_Homo sapiens_hsa046701.30256915
22Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.27462896
23Thyroid hormone synthesis_Homo sapiens_hsa049181.26507165
24TNF signaling pathway_Homo sapiens_hsa046681.24763455
25Choline metabolism in cancer_Homo sapiens_hsa052311.23818456
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23698950
27Pancreatic secretion_Homo sapiens_hsa049721.22055465
28Legionellosis_Homo sapiens_hsa051341.21443380
29Small cell lung cancer_Homo sapiens_hsa052221.18614554
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16853772
31Proteoglycans in cancer_Homo sapiens_hsa052051.16224771
32VEGF signaling pathway_Homo sapiens_hsa043701.14487706
33Histidine metabolism_Homo sapiens_hsa003401.10150101
34Caffeine metabolism_Homo sapiens_hsa002321.07491114
35Hepatitis C_Homo sapiens_hsa051601.04346596
36Bladder cancer_Homo sapiens_hsa052191.03173508
37Salmonella infection_Homo sapiens_hsa051321.02086294
38Adherens junction_Homo sapiens_hsa045201.01713816
39Focal adhesion_Homo sapiens_hsa045101.00462220
40Renal cell carcinoma_Homo sapiens_hsa052110.99374074
41Salivary secretion_Homo sapiens_hsa049700.98796518
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91604283
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91010004
44p53 signaling pathway_Homo sapiens_hsa041150.88371537
45GnRH signaling pathway_Homo sapiens_hsa049120.87907797
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87744696
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.85343431
48HIF-1 signaling pathway_Homo sapiens_hsa040660.85222733
49Antigen processing and presentation_Homo sapiens_hsa046120.83819840
50Malaria_Homo sapiens_hsa051440.83685629
51Shigellosis_Homo sapiens_hsa051310.80886243
52Influenza A_Homo sapiens_hsa051640.79499905
53Estrogen signaling pathway_Homo sapiens_hsa049150.78880069
54Sphingolipid signaling pathway_Homo sapiens_hsa040710.78642087
55Glycerophospholipid metabolism_Homo sapiens_hsa005640.77045773
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76586177
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.75120507
58Osteoclast differentiation_Homo sapiens_hsa043800.71911847
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71837737
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71171577
61Dorso-ventral axis formation_Homo sapiens_hsa043200.70700195
62ErbB signaling pathway_Homo sapiens_hsa040120.68922699
63MAPK signaling pathway_Homo sapiens_hsa040100.67211118
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67167848
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67015800
66Notch signaling pathway_Homo sapiens_hsa043300.66873904
67Thyroid cancer_Homo sapiens_hsa052160.66622863
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63856992
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62978791
70Phototransduction_Homo sapiens_hsa047440.62793655
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62692295
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.60909300
73Bile secretion_Homo sapiens_hsa049760.60817150
74Inositol phosphate metabolism_Homo sapiens_hsa005620.60596189
75Insulin resistance_Homo sapiens_hsa049310.60548037
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.60494734
77Collecting duct acid secretion_Homo sapiens_hsa049660.59686325
78Insulin signaling pathway_Homo sapiens_hsa049100.57770004
79Phenylalanine metabolism_Homo sapiens_hsa003600.56084169
80Gastric acid secretion_Homo sapiens_hsa049710.55426381
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55391303
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.54689837
83Hippo signaling pathway_Homo sapiens_hsa043900.54509577
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.54257578
85Renin secretion_Homo sapiens_hsa049240.52398835
86Axon guidance_Homo sapiens_hsa043600.51332794
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51111019
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50855796
89Ras signaling pathway_Homo sapiens_hsa040140.50241314
90Platelet activation_Homo sapiens_hsa046110.50157634
91Tuberculosis_Homo sapiens_hsa051520.49079895
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48733508
93Oxytocin signaling pathway_Homo sapiens_hsa049210.48408230
94Nitrogen metabolism_Homo sapiens_hsa009100.48053868
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47966407
96Hematopoietic cell lineage_Homo sapiens_hsa046400.47946045
97Steroid biosynthesis_Homo sapiens_hsa001000.47560459
98Prion diseases_Homo sapiens_hsa050200.47376918
99Dilated cardiomyopathy_Homo sapiens_hsa054140.47170177
100Glutamatergic synapse_Homo sapiens_hsa047240.46053223
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45552248
102Apoptosis_Homo sapiens_hsa042100.45323465
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45112001
104MicroRNAs in cancer_Homo sapiens_hsa052060.45057728
105Arginine biosynthesis_Homo sapiens_hsa002200.44503839
106NF-kappa B signaling pathway_Homo sapiens_hsa040640.44257113
107NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43831628
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42837792
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42769575
110Long-term potentiation_Homo sapiens_hsa047200.42500304
111Glioma_Homo sapiens_hsa052140.42139764
112Fructose and mannose metabolism_Homo sapiens_hsa000510.42099091
113Melanogenesis_Homo sapiens_hsa049160.41890015
114Acute myeloid leukemia_Homo sapiens_hsa052210.41839726
115Pathways in cancer_Homo sapiens_hsa052000.41506692
116Retinol metabolism_Homo sapiens_hsa008300.40890132
117Basal cell carcinoma_Homo sapiens_hsa052170.40770215
118Pancreatic cancer_Homo sapiens_hsa052120.40116587
119Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39381212
120Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39360061
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39233561
122Phagosome_Homo sapiens_hsa041450.38895385
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38417931
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.37132200
125Long-term depression_Homo sapiens_hsa047300.36544384
126FoxO signaling pathway_Homo sapiens_hsa040680.35587222
127PPAR signaling pathway_Homo sapiens_hsa033200.35164881
128Rap1 signaling pathway_Homo sapiens_hsa040150.33968730
129Galactose metabolism_Homo sapiens_hsa000520.33543700
130Chronic myeloid leukemia_Homo sapiens_hsa052200.33487318
131Primary bile acid biosynthesis_Homo sapiens_hsa001200.32797849
132Endocytosis_Homo sapiens_hsa041440.32354282
133Cyanoamino acid metabolism_Homo sapiens_hsa004600.32319485
134Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32138715
135Toll-like receptor signaling pathway_Homo sapiens_hsa046200.31999972
136Vibrio cholerae infection_Homo sapiens_hsa051100.31426899
137ABC transporters_Homo sapiens_hsa020100.25978630
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24699457

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