SPRR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1apical protein localization (GO:0045176)9.45527048
2negative regulation of bone mineralization (GO:0030502)9.20060522
3sarcoplasmic reticulum calcium ion transport (GO:0070296)8.37726402
4negative regulation of biomineral tissue development (GO:0070168)8.14822261
5regulation of keratinocyte differentiation (GO:0045616)7.46005016
6negative regulation of homotypic cell-cell adhesion (GO:0034111)7.34616719
7regulation of toll-like receptor 4 signaling pathway (GO:0034143)7.09903053
8response to vitamin A (GO:0033189)7.04737094
9hair cell differentiation (GO:0035315)6.83453615
10membrane raft organization (GO:0031579)6.75791940
11localization within membrane (GO:0051668)6.70476710
12asymmetric protein localization (GO:0008105)6.58102374
13regulation of relaxation of muscle (GO:1901077)6.27845121
14O-glycan processing (GO:0016266)6.27397669
15* epidermis development (GO:0008544)6.13159722
16positive regulation of endothelial cell differentiation (GO:0045603)6.04682239
17regulation of skeletal muscle contraction (GO:0014819)5.91848455
18* peptide cross-linking (GO:0018149)5.78103751
19negative regulation of interleukin-17 production (GO:0032700)5.75809910
20purine nucleotide salvage (GO:0032261)5.75097920
21skeletal muscle contraction (GO:0003009)5.66897615
22muscle organ morphogenesis (GO:0048644)5.62888262
23regulation of cardioblast proliferation (GO:0003264)5.48403892
24regulation of secondary heart field cardioblast proliferation (GO:0003266)5.48403892
25transepithelial transport (GO:0070633)5.46246448
26coronary vasculature morphogenesis (GO:0060977)5.45515327
27water homeostasis (GO:0030104)5.37542977
28actin-myosin filament sliding (GO:0033275)5.32612112
29muscle filament sliding (GO:0030049)5.32612112
30long-chain fatty acid biosynthetic process (GO:0042759)5.30764297
31regulation of platelet aggregation (GO:0090330)5.23509652
32innate immune response in mucosa (GO:0002227)5.15440389
33negative regulation of cell-cell adhesion (GO:0022408)5.14591183
34lymph vessel development (GO:0001945)5.13721469
35positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)5.10548388
36regulation of skeletal muscle cell differentiation (GO:2001014)5.06186306
37superoxide anion generation (GO:0042554)4.90154304
38outer ear morphogenesis (GO:0042473)4.87730922
39regulation of mitochondrial depolarization (GO:0051900)4.86450470
40linoleic acid metabolic process (GO:0043651)4.85766328
41positive regulation of p38MAPK cascade (GO:1900745)4.84615544
42ectoderm development (GO:0007398)4.81745453
43tooth mineralization (GO:0034505)4.76971286
44cellular response to retinoic acid (GO:0071300)4.59955742
45cellular response to epidermal growth factor stimulus (GO:0071364)4.56366884
46regulation of epidermal cell differentiation (GO:0045604)4.48823317
47eyelid development in camera-type eye (GO:0061029)4.36736476
48negative regulation of toll-like receptor signaling pathway (GO:0034122)4.35022800
49actin-mediated cell contraction (GO:0070252)4.35001890
50negative regulation of cytokine-mediated signaling pathway (GO:0001960)4.34987417
51establishment of planar polarity (GO:0001736)4.26278351
52establishment of tissue polarity (GO:0007164)4.26278351
53protein O-linked glycosylation (GO:0006493)4.24315304
54regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.21929975
55regulation of protein polyubiquitination (GO:1902914)4.13511000
56antimicrobial humoral response (GO:0019730)4.13014660
57negative regulation of response to cytokine stimulus (GO:0060761)4.11853826
58regulation of endothelial cell differentiation (GO:0045601)4.11359071
59intestinal epithelial cell development (GO:0060576)4.10089484
60Peyers patch development (GO:0048541)4.06636845
61mucosal-associated lymphoid tissue development (GO:0048537)4.06636845
62positive regulation of chemokine biosynthetic process (GO:0045080)4.05694423
63regulation of cholesterol homeostasis (GO:2000188)4.04459385
64mucosal immune response (GO:0002385)4.02794864
65negative regulation of platelet activation (GO:0010544)4.01246912
66planar cell polarity pathway involved in neural tube closure (GO:0090179)3.98402214
67keratinocyte proliferation (GO:0043616)3.96178838
68negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.92320568
69negative regulation of calcium ion transmembrane transport (GO:1903170)3.92320568
70cellular response to glucocorticoid stimulus (GO:0071385)3.88728749
71negative regulation of thymocyte apoptotic process (GO:0070244)3.87697168
72muscle cell fate commitment (GO:0042693)3.80707377
73embryonic viscerocranium morphogenesis (GO:0048703)3.80674584
74organ or tissue specific immune response (GO:0002251)3.80582508
75lipoxygenase pathway (GO:0019372)3.79543180
76histamine secretion (GO:0001821)3.76850998
77regulation of penile erection (GO:0060405)3.76147042
78regulation of integrin-mediated signaling pathway (GO:2001044)3.75027979
79cellular response to corticosteroid stimulus (GO:0071384)3.74204651
80response to epidermal growth factor (GO:0070849)3.72309836
81creatine metabolic process (GO:0006600)3.70320418
82plasma membrane repair (GO:0001778)3.69687677
83positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.64751517
84regulation of bile acid biosynthetic process (GO:0070857)3.63307037
85regulation of p38MAPK cascade (GO:1900744)3.60081958
86* keratinocyte differentiation (GO:0030216)3.59512342
87establishment of skin barrier (GO:0061436)3.59291518
88regulation of interleukin-17 production (GO:0032660)3.56711645
89positive regulation of myotube differentiation (GO:0010831)3.55932222
90hair follicle morphogenesis (GO:0031069)3.55733494
91positive regulation of protein depolymerization (GO:1901881)3.52873382
92regulation of ruffle assembly (GO:1900027)3.51640005
93positive regulation of vasodilation (GO:0045909)3.51194590
94actin filament-based movement (GO:0030048)3.47489233
95negative regulation of cell-substrate adhesion (GO:0010812)3.44473315
96* epithelial cell differentiation (GO:0030855)3.43752104
97negative regulation of interferon-gamma production (GO:0032689)3.42415583
98desmosome organization (GO:0002934)3.40258427
99response to vitamin E (GO:0033197)3.36686665
100bundle of His cell to Purkinje myocyte communication (GO:0086069)3.33566326
101regulation of water loss via skin (GO:0033561)3.28541455
102myotube differentiation (GO:0014902)3.28132995
103mature B cell differentiation involved in immune response (GO:0002313)3.27451989
104regulation of interferon-beta biosynthetic process (GO:0045357)3.24521135
105hypotonic response (GO:0006971)3.22752032
106striated muscle contraction (GO:0006941)3.22684802
107cranial nerve morphogenesis (GO:0021602)3.19955638
108regulation of germinal center formation (GO:0002634)3.19943984
109negative regulation of muscle cell apoptotic process (GO:0010656)3.16713482
110regulation of epidermis development (GO:0045682)3.14966660
111regulation of hippo signaling (GO:0035330)3.14583130
112defense response to fungus (GO:0050832)3.08622327
113tricarboxylic acid cycle (GO:0006099)3.00879850
114negative regulation of B cell apoptotic process (GO:0002903)3.00448310
115keratinocyte development (GO:0003334)2.99746302
116regulation of homotypic cell-cell adhesion (GO:0034110)2.99154953
117myofibril assembly (GO:0030239)2.95670749
118positive regulation of T cell differentiation in thymus (GO:0033089)2.95657044
119regulation of chemokine biosynthetic process (GO:0045073)2.95203743
120* epithelium development (GO:0060429)2.93565580
121sarcomere organization (GO:0045214)2.93535615
122early endosome to late endosome transport (GO:0045022)2.92857529
123positive regulation of skeletal muscle tissue development (GO:0048643)2.91397956
124skeletal muscle adaptation (GO:0043501)2.91014092
125skeletal muscle fiber development (GO:0048741)2.85951115
126endosome organization (GO:0007032)2.85338422
127Rho protein signal transduction (GO:0007266)2.85275001
128histamine transport (GO:0051608)2.83884821
129regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.82319381
130negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.78756587
131lymph node development (GO:0048535)2.75807390
132adenosine metabolic process (GO:0046085)2.75773112
133vitamin A metabolic process (GO:0006776)2.75512095
134nucleotide salvage (GO:0043173)2.74468838
135regulation of type 2 immune response (GO:0002828)2.73535287
136citrulline biosynthetic process (GO:0019240)2.72727268
137multicellular organismal water homeostasis (GO:0050891)2.71728481
138hippo signaling (GO:0035329)2.70982003
139response to muscle activity (GO:0014850)2.69155582
140regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.69128720
141regulation of calcium ion transmembrane transporter activity (GO:1901019)2.65978294
142regulation of calcium ion transmembrane transport (GO:1903169)2.65978294
143regulation of establishment of planar polarity (GO:0090175)2.63003203
144outflow tract septum morphogenesis (GO:0003148)2.61890469
145regulation of T cell migration (GO:2000404)2.61867052
146response to retinoic acid (GO:0032526)2.61847809
147N-terminal protein amino acid acetylation (GO:0006474)2.60746336
148purine nucleobase biosynthetic process (GO:0009113)2.59750261
149positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.59716891
150negative regulation of ion transmembrane transporter activity (GO:0032413)2.57360053
151hemidesmosome assembly (GO:0031581)2.57328232
152interkinetic nuclear migration (GO:0022027)2.55869237
153negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.55405012
154response to leptin (GO:0044321)2.55058494
155positive regulation of protein complex disassembly (GO:0043243)2.53863936
156positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.53646260
157muscle contraction (GO:0006936)2.53527189
158biomineral tissue development (GO:0031214)2.52628163
159regulation of developmental pigmentation (GO:0048070)2.52188959
160sodium ion homeostasis (GO:0055078)2.51347791
161excretion (GO:0007588)2.51338941
162regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.49814028
163negative regulation of ossification (GO:0030279)2.49431273
164microtubule nucleation (GO:0007020)2.47976032
165carnitine shuttle (GO:0006853)2.47889921
166positive regulation of Cdc42 GTPase activity (GO:0043089)2.47333773
167regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.46618674
168purine deoxyribonucleotide catabolic process (GO:0009155)2.46581870
169otic vesicle formation (GO:0030916)2.46016030
170fatty acid transmembrane transport (GO:1902001)2.45889105
171pharyngeal system development (GO:0060037)2.44962649
172* epidermal cell differentiation (GO:0009913)2.44359234
173enteric nervous system development (GO:0048484)2.43619630
174cochlea morphogenesis (GO:0090103)2.43251366
175transcytosis (GO:0045056)2.42623437
176Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.41876491
177regulation of membrane protein ectodomain proteolysis (GO:0051043)2.40068209
178detection of bacterium (GO:0016045)2.36133297
179regulation of membrane depolarization (GO:0003254)2.35914178
180regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.33552107
181* keratinization (GO:0031424)17.7920236
182cell wall macromolecule catabolic process (GO:0016998)13.5097766
183cell wall macromolecule metabolic process (GO:0044036)13.5097766
184negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)13.4206397

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.67165693
2ZNF652_21678463_ChIP-ChIP_ZR75-1_Human7.60964062
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.94814672
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.59474752
5ESR1_21235772_ChIP-Seq_MCF-7_Human3.20171440
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.79801725
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.63518537
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.43402233
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.20473397
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.17571303
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.13562116
12ZNF263_19887448_ChIP-Seq_K562_Human2.00845609
13FOXM1_26456572_ChIP-Seq_MCF-7_Human1.99169306
14KLF5_25053715_ChIP-Seq_YYC3_Human1.98283742
15CLOCK_20551151_ChIP-Seq_293T_Human1.87238132
16SOX2_27498859_Chip-Seq_STOMACH_Mouse1.86133155
17GATA1_22025678_ChIP-Seq_K562_Human1.85487619
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.84510606
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.84299640
20CTCF_20526341_ChIP-Seq_ESCs_Human1.83004643
21* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.81311750
22HIF1A_21447827_ChIP-Seq_MCF-7_Human1.80563333
23CDX2_20551321_ChIP-Seq_CACO-2_Human1.78768991
24* CTCF_27219007_Chip-Seq_Bcells_Human1.71765175
25AHR_22903824_ChIP-Seq_MCF-7_Human1.71540933
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61358607
27BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.57980279
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.56856369
29PPAR_26484153_Chip-Seq_NCI-H1993_Human1.56259486
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55660518
31GATA4_25053715_ChIP-Seq_YYC3_Human1.55334750
32RACK7_27058665_Chip-Seq_MCF-7_Human1.51075650
33P63_26484246_Chip-Seq_KERATINOCYTES_Human1.48807313
34TCF4_18268006_ChIP-ChIP_LS174T_Human1.48739495
35CJUN_26792858_Chip-Seq_BT549_Human1.46526057
36RXR_22158963_ChIP-Seq_LIVER_Mouse1.42454974
37VDR_22108803_ChIP-Seq_LS180_Human1.41430042
38TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39576795
39DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.39386917
40GATA6_25053715_ChIP-Seq_YYC3_Human1.35770019
41* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.35669383
42SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.35465965
43TP63_23658742_ChIP-Seq_EP156T_Human1.34143065
44SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.31079845
45SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.31079845
46SMAD3_21741376_ChIP-Seq_HESCs_Human1.30684650
47ARNT_22903824_ChIP-Seq_MCF-7_Human1.30083776
48TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28342751
49PPARA_22158963_ChIP-Seq_LIVER_Mouse1.27673632
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27665416
51FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.26596546
52CTNNB1_20460455_ChIP-Seq_HCT116_Human1.26165919
53EGR1_19032775_ChIP-ChIP_M12_Human1.23004389
54SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22562639
55TBX20_22328084_ChIP-Seq_HEART_Mouse1.20450961
56TBX20_22080862_ChIP-Seq_HEART_Mouse1.20450961
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.19032350
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17776893
59JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17476529
60JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16302027
61* SOX2_20726797_ChIP-Seq_SW620_Human1.15516390
62FOXH1_21741376_ChIP-Seq_ESCs_Human1.15294484
63STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.14825873
64* ERG_20517297_ChIP-Seq_VCAP_Human1.13016589
65EP300_21415370_ChIP-Seq_HL-1_Mouse1.12642419
66RXR_22108803_ChIP-Seq_LS180_Human1.12429846
67* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12356524
68BCOR_27268052_Chip-Seq_Bcells_Human1.11977807
69MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.11650931
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11643651
71LXR_22158963_ChIP-Seq_LIVER_Mouse1.08978318
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08747701
73NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08689353
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.07283762
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07279365
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.06774376
77LXR_22292898_ChIP-Seq_THP-1_Human1.06639741
78HTT_18923047_ChIP-ChIP_STHdh_Human1.05589597
79FOXA1_25552417_ChIP-Seq_VCAP_Human1.05180664
80ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05163332
81SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04823641
82RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03911412
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03772311
84NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03190351
85ELK3_25401928_ChIP-Seq_HUVEC_Human1.02765507
86FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.02628674
87SMC4_20622854_ChIP-Seq_HELA_Human1.00112939
88OCT1_27270436_Chip-Seq_PROSTATE_Human0.99416856
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99358270
90NANOG_20526341_ChIP-Seq_ESCs_Human0.99190148
91ERG_21242973_ChIP-ChIP_JURKAT_Human0.98963350
92AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98962928
93* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.98599481
94SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98458409
95STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.97539328
96AR_25329375_ChIP-Seq_VCAP_Human0.96925710
97EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96419738
98STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95989106
99KDM2B_26808549_Chip-Seq_DND41_Human0.95754284
100SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95032726
101ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94586435
102SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92701135
103RUNX_20019798_ChIP-Seq_JUKART_Human0.92638006
104RUNX1_27514584_Chip-Seq_MCF-7_Human0.92530970
105* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.92258926
106KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91243380
107NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.91221064
108MTF2_20144788_ChIP-Seq_MESCs_Mouse0.90970745
109* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90246894
110* RBPJ_21746931_ChIP-Seq_IB4_Human0.90246875
111ELF5_23300383_ChIP-Seq_T47D_Human0.90241759
112Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.89831754
113PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.89336979
114SA1_27219007_Chip-Seq_ERYTHROID_Human0.88920064
115P68_20966046_ChIP-Seq_HELA_Human0.88568101
116NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87689445
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87689445
118STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87348466
119EZH2_18974828_ChIP-Seq_MESCs_Mouse0.86888706
120RNF2_18974828_ChIP-Seq_MESCs_Mouse0.86888706
121CTCF_21964334_ChIP-Seq_BJAB-B_Human0.86678477
122SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.86152904
123HOXB7_26014856_ChIP-Seq_BT474_Human0.86089660
124CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.85707392
125WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85460643
126* GATA3_24758297_ChIP-Seq_MCF-7_Human0.85285630
127FOXH1_21741376_ChIP-Seq_EPCs_Human0.84645421
128UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.84263928
129SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83866979
130ISL1_27105846_Chip-Seq_CPCs_Mouse0.83829861
131P300_27058665_Chip-Seq_ZR-75-30cells_Human0.83761939
132AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83445128
133ZNF217_24962896_ChIP-Seq_MCF-7_Human0.83216876
134SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.83007722
135TP63_22573176_ChIP-Seq_HFKS_Human0.82441733
136ZFP281_18757296_ChIP-ChIP_E14_Mouse0.81665555
137EZH2_27294783_Chip-Seq_ESCs_Mouse0.81558210
138TP53_16413492_ChIP-PET_HCT116_Human0.81468574
139JARID2_20075857_ChIP-Seq_MESCs_Mouse0.81417873
140YY1_22570637_ChIP-Seq_MALME-3M_Human0.81213282
141GATA1_19941826_ChIP-Seq_K562_Human0.81079595
142FOXO3_23340844_ChIP-Seq_DLD1_Human0.80650442
143STAT6_21828071_ChIP-Seq_BEAS2B_Human0.80615246
144PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80589471
145CEBPB_22108803_ChIP-Seq_LS180_Human0.80411326
146* GATA6_21074721_ChIP-Seq_CACO-2_Human0.80297266
147MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.80241611
148* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.79855125
149TP53_20018659_ChIP-ChIP_R1E_Mouse0.79538492
150BCL6_27268052_Chip-Seq_Bcells_Human0.78262003
151KDM2B_26808549_Chip-Seq_K562_Human0.78219555
152PCGF2_27294783_Chip-Seq_ESCs_Mouse0.77285838
153ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77074944
154* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.76475326
155CSB_26484114_Chip-Seq_FIBROBLAST_Human0.75521199
156ATF3_27146783_Chip-Seq_COLON_Human0.74926506

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002234_abnormal_pharynx_morphology5.18266652
2MP0002796_impaired_skin_barrier4.86195523
3MP0005275_abnormal_skin_tensile4.57125492
4MP0000751_myopathy4.52500231
5MP0003646_muscle_fatigue4.13672455
6MP0000467_abnormal_esophagus_morphology3.90836005
7MP0010352_gastrointestinal_tract_polyps3.66989779
8MP0000749_muscle_degeneration3.55492974
9MP0000762_abnormal_tongue_morphology3.40647639
10MP0002837_dystrophic_cardiac_calcinosis2.94281759
11MP0005501_abnormal_skin_physiology2.71070281
12MP0004145_abnormal_muscle_electrophysio2.50362344
13MP0000747_muscle_weakness2.46999817
14MP0009697_abnormal_copulation2.45341674
15MP0010234_abnormal_vibrissa_follicle2.40176309
16MP0000759_abnormal_skeletal_muscle2.29833246
17MP0002095_abnormal_skin_pigmentation2.29205189
18MP0001243_abnormal_dermal_layer2.28175122
19MP0002106_abnormal_muscle_physiology2.24211090
20MP0004130_abnormal_muscle_cell2.11400338
21MP0000678_abnormal_parathyroid_gland2.10360375
22MP0004185_abnormal_adipocyte_glucose2.05128948
23MP0009780_abnormal_chondrocyte_physiolo2.02661797
24MP0002098_abnormal_vibrissa_morphology2.01285136
25MP0003252_abnormal_bile_duct2.00426422
26MP0001879_abnormal_lymphatic_vessel2.00381218
27MP0000371_diluted_coat_color1.99815853
28MP0003705_abnormal_hypodermis_morpholog1.98531586
29MP0004087_abnormal_muscle_fiber1.96893149
30MP0004036_abnormal_muscle_relaxation1.91892762
31MP0000733_abnormal_muscle_development1.88394162
32MP0000750_abnormal_muscle_regeneration1.85283461
33MP0005369_muscle_phenotype1.79937177
34MP0002332_abnormal_exercise_endurance1.67284217
35MP0005620_abnormal_muscle_contractility1.60366902
36MP0001958_emphysema1.58639716
37MP0003806_abnormal_nucleotide_metabolis1.54694180
38MP0002269_muscular_atrophy1.52900967
39MP0005409_darkened_coat_color1.48291210
40MP0005503_abnormal_tendon_morphology1.47243816
41MP0000377_abnormal_hair_follicle1.44956765
42MP0004264_abnormal_extraembryonic_tissu1.43590918
43MP0000383_abnormal_hair_follicle1.36606899
44MP0000470_abnormal_stomach_morphology1.35767952
45MP0001851_eye_inflammation1.33537461
46MP0000566_synostosis1.32001277
47MP0004084_abnormal_cardiac_muscle1.30398029
48MP0005670_abnormal_white_adipose1.29691392
49MP0005330_cardiomyopathy1.29593124
50MP0002249_abnormal_larynx_morphology1.29325994
51MP0005666_abnormal_adipose_tissue1.28825798
52MP0002972_abnormal_cardiac_muscle1.25189785
53MP0005266_abnormal_metabolism1.21277458
54MP0004885_abnormal_endolymph1.21021465
55MP0003950_abnormal_plasma_membrane1.19906531
56MP0003566_abnormal_cell_adhesion1.16805554
57MP0001216_abnormal_epidermal_layer1.16646692
58MP0010771_integument_phenotype1.16418599
59MP0009333_abnormal_splenocyte_physiolog1.15833079
60MP0006036_abnormal_mitochondrial_physio1.11201763
61MP0002127_abnormal_cardiovascular_syste1.10383584
62MP0000579_abnormal_nail_morphology1.10098943
63MP0004270_analgesia1.09753515
64MP0002909_abnormal_adrenal_gland1.08470493
65MP0004947_skin_inflammation1.07993809
66MP0001765_abnormal_ion_homeostasis1.02063031
67MP0002138_abnormal_hepatobiliary_system0.94930390
68MP0003221_abnormal_cardiomyocyte_apopto0.91510126
69MP0005385_cardiovascular_system_phenoty0.90441362
70MP0001544_abnormal_cardiovascular_syste0.90441362
71MP0001299_abnormal_eye_distance/0.89132055
72MP0000647_abnormal_sebaceous_gland0.88912895
73MP0005167_abnormal_blood-brain_barrier0.88811429
74MP0002075_abnormal_coat/hair_pigmentati0.88413560
75MP0004484_altered_response_of0.88222274
76MP0005365_abnormal_bile_salt0.86924701
77MP0003453_abnormal_keratinocyte_physiol0.85893245
78MP0002139_abnormal_hepatobiliary_system0.85542988
79MP0000343_altered_response_to0.84907911
80MP0001177_atelectasis0.84373549
81MP0003191_abnormal_cellular_cholesterol0.83660205
82MP0004233_abnormal_muscle_weight0.81827743
83MP0005375_adipose_tissue_phenotype0.80612764
84MP0001502_abnormal_circadian_rhythm0.80139201
85MP0010030_abnormal_orbit_morphology0.80077160
86MP0001191_abnormal_skin_condition0.79533625
87MP0008438_abnormal_cutaneous_collagen0.79353966
88MP0006138_congestive_heart_failure0.78987567
89MP0001784_abnormal_fluid_regulation0.78289427
90MP0002254_reproductive_system_inflammat0.78072603
91MP0004215_abnormal_myocardial_fiber0.76939222
92MP0000613_abnormal_salivary_gland0.76058208
93MP0000003_abnormal_adipose_tissue0.74385518
94MP0010630_abnormal_cardiac_muscle0.74168458
95MP0000465_gastrointestinal_hemorrhage0.73447538
96MP0003329_amyloid_beta_deposits0.71335536
97MP0005023_abnormal_wound_healing0.70711685
98MP0010368_abnormal_lymphatic_system0.69988870
99MP0004782_abnormal_surfactant_physiolog0.68647651
100MP0009931_abnormal_skin_appearance0.66663305
101MP0009053_abnormal_anal_canal0.65337774
102MP0000427_abnormal_hair_cycle0.65167624
103MP0002971_abnormal_brown_adipose0.65064231
104MP0000367_abnormal_coat/_hair0.64718242
105MP0002108_abnormal_muscle_morphology0.64508588
106MP0002060_abnormal_skin_morphology0.63863693
107MP0003878_abnormal_ear_physiology0.63309754
108MP0005377_hearing/vestibular/ear_phenot0.63309754
109MP0004272_abnormal_basement_membrane0.61217296
110MP0010678_abnormal_skin_adnexa0.60637643
111MP0000049_abnormal_middle_ear0.60303299
112MP0009115_abnormal_fat_cell0.59664555
113MP0002166_altered_tumor_susceptibility0.58852556
114MP0001186_pigmentation_phenotype0.58527570
115MP0003656_abnormal_erythrocyte_physiolo0.58183940
116MP0003075_altered_response_to0.58135737
117MP0004858_abnormal_nervous_system0.57189320
118MP0005636_abnormal_mineral_homeostasis0.56633647
119MP0001756_abnormal_urination0.54750764
120MP0005165_increased_susceptibility_to0.54651942
121MP0005166_decreased_susceptibility_to0.52143249
122MP0008875_abnormal_xenobiotic_pharmacok0.51034118
123MP0000013_abnormal_adipose_tissue0.50987414
124MP0008775_abnormal_heart_ventricle0.50971652
125MP0008961_abnormal_basal_metabolism0.50709911
126MP0003828_pulmonary_edema0.50101679
127MP0003937_abnormal_limbs/digits/tail_de0.49605070
128MP0001346_abnormal_lacrimal_gland0.49391490
129MP0000681_abnormal_thyroid_gland0.49267576
130MP0004043_abnormal_pH_regulation0.47674263
131MP0010329_abnormal_lipoprotein_level0.46778259
132MP0009643_abnormal_urine_homeostasis0.41727178
133MP0002136_abnormal_kidney_physiology0.41215976
134MP0001270_distended_abdomen0.40655500
135MP0005076_abnormal_cell_differentiation0.39876433
136MP0001873_stomach_inflammation0.37542803
137MP0001340_abnormal_eyelid_morphology0.37337650
138MP0000920_abnormal_myelination0.34661833
139MP0005451_abnormal_body_composition0.33890195
140MP0002006_tumorigenesis0.33808279
141MP0010386_abnormal_urinary_bladder0.33585994
142MP0003755_abnormal_palate_morphology0.32456167
143MP0005193_abnormal_anterior_eye0.32162124
144MP0003724_increased_susceptibility_to0.30772307
145MP0000631_abnormal_neuroendocrine_gland0.29967431
146MP0000462_abnormal_digestive_system0.28353091
147MP0001853_heart_inflammation0.28296384
148MP0000477_abnormal_intestine_morphology0.27611023
149MP0003941_abnormal_skin_development0.26186993
150MP0003938_abnormal_ear_development0.24783728
151MP0002653_abnormal_ependyma_morphology0.23825103
152MP0003567_abnormal_fetal_cardiomyocyte0.22044023
153MP0004197_abnormal_fetal_growth/weight/0.21577188
154MP0008004_abnormal_stomach_pH0.21454176
155MP0002111_abnormal_tail_morphology0.20342681

Predicted human phenotypes

RankGene SetZ-score
1Pustule (HP:0200039)9.75557994
2Erythroderma (HP:0001019)7.01992593
3Lip pit (HP:0100267)6.81357388
4Distal arthrogryposis (HP:0005684)6.52615214
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.18334580
6Muscle fiber inclusion bodies (HP:0100299)6.18134148
7Hyperactive renin-angiotensin system (HP:0000841)6.16916049
8Abnormality of small intestinal villus morphology (HP:0011472)6.05949529
9Villous atrophy (HP:0011473)6.05949529
10Exercise-induced myalgia (HP:0003738)6.01310156
11Parakeratosis (HP:0001036)5.64866597
12Nemaline bodies (HP:0003798)5.57480366
13Round ear (HP:0100830)5.43613011
14Ulnar deviation of the wrist (HP:0003049)4.98378930
15Type 1 muscle fiber predominance (HP:0003803)4.85697812
16Nasal polyposis (HP:0100582)4.81737277
17Exercise-induced muscle cramps (HP:0003710)4.78213948
18Sparse scalp hair (HP:0002209)4.78138596
19Increased connective tissue (HP:0009025)4.77938341
20Abnormality of nail color (HP:0100643)4.75140735
21Difficulty running (HP:0009046)4.61248452
22Muscle hypertrophy of the lower extremities (HP:0008968)4.56495480
23Absent phalangeal crease (HP:0006109)4.48148914
24Brittle hair (HP:0002299)4.45005097
25Calf muscle hypertrophy (HP:0008981)4.43706502
26Myopathic facies (HP:0002058)4.40359772
27Calcaneovalgus deformity (HP:0001848)4.32303044
28Palmoplantar hyperkeratosis (HP:0000972)4.28848424
29Myoglobinuria (HP:0002913)4.17169062
30Muscle fiber splitting (HP:0003555)4.16574076
31Decreased circulating renin level (HP:0003351)4.11042983
32Erythema (HP:0010783)4.09766465
33Chronic bronchitis (HP:0004469)4.08151651
34Hyporeflexia of lower limbs (HP:0002600)4.07901346
35Palmar hyperkeratosis (HP:0010765)4.06706273
36Autoimmune thrombocytopenia (HP:0001973)4.05258559
37Abnormality of the nasal mucosa (HP:0000433)4.02730883
38Increased IgE level (HP:0003212)3.95657287
39Unilateral renal agenesis (HP:0000122)3.82525093
40Deformed tarsal bones (HP:0008119)3.81450449
41Rimmed vacuoles (HP:0003805)3.79690147
42Acanthosis nigricans (HP:0000956)3.74615743
43Abnormal finger flexion creases (HP:0006143)3.71757907
44Abnormality of the salivary glands (HP:0010286)3.68928907
45Increased variability in muscle fiber diameter (HP:0003557)3.67524272
46Hypokalemic alkalosis (HP:0001949)3.61621806
47Neonatal hypoglycemia (HP:0001998)3.59958084
48Right ventricular cardiomyopathy (HP:0011663)3.58645632
49Mesangial abnormality (HP:0001966)3.58553000
50Dehydration (HP:0001944)3.51335618
51Abnormality of skeletal muscle fiber size (HP:0012084)3.50711214
52Plantar hyperkeratosis (HP:0007556)3.47021270
53Cystic hygroma (HP:0000476)3.42527676
54Congenital malformation of the right heart (HP:0011723)3.38509368
55Double outlet right ventricle (HP:0001719)3.38509368
56Autoimmune hemolytic anemia (HP:0001890)3.31669187
57Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.26779826
58Nail dystrophy (HP:0008404)3.26021796
59Abnormality of chloride homeostasis (HP:0011422)3.24384729
60Eczematoid dermatitis (HP:0000976)3.22881040
61Hyperaldosteronism (HP:0000859)3.19937568
62Distal lower limb muscle weakness (HP:0009053)3.15620728
63Abnormality of renin-angiotensin system (HP:0000847)3.15561646
64Renal salt wasting (HP:0000127)3.13914757
65Oligodontia (HP:0000677)3.10718950
66Abnormality of the calf musculature (HP:0001430)3.05612929
67Abnormality of the parathyroid morphology (HP:0011766)3.02298186
68EMG: myopathic abnormalities (HP:0003458)3.01920547
69Congenital ichthyosiform erythroderma (HP:0007431)3.01750590
70Alopecia of scalp (HP:0002293)2.97359744
71Muscle stiffness (HP:0003552)2.91657343
72Myotonia (HP:0002486)2.90948301
73Furrowed tongue (HP:0000221)2.90302468
74Cholelithiasis (HP:0001081)2.89723181
75Paralysis (HP:0003470)2.88471052
76Abnormality of the aortic arch (HP:0012303)2.87065585
77Fragile nails (HP:0001808)2.80981215
78Areflexia of lower limbs (HP:0002522)2.79772830
79Distal lower limb amyotrophy (HP:0008944)2.79503490
80Cupped ribs (HP:0000887)2.74049535
81Difficulty climbing stairs (HP:0003551)2.73331412
82Hyperthyroidism (HP:0000836)2.72709751
83Abnormality of the calcaneus (HP:0008364)2.72135968
84Rhabdomyolysis (HP:0003201)2.70626808
85Hypotrichosis (HP:0001006)2.65635041
86Abnormal gallbladder morphology (HP:0012437)2.63603004
87Neck muscle weakness (HP:0000467)2.63264924
88Frequent falls (HP:0002359)2.58249050
89Urticaria (HP:0001025)2.54390101
90Abnormality of B cell number (HP:0010975)2.54322416
91B lymphocytopenia (HP:0010976)2.54322416
92Absent eyelashes (HP:0000561)2.53684588
93Absence seizures (HP:0002121)2.47342288
94Facial diplegia (HP:0001349)2.47305775
95Hypergammaglobulinemia (HP:0010702)2.38003281
96Malnutrition (HP:0004395)2.37721176
97Hypoplastic labia majora (HP:0000059)2.34639249
98Hoarse voice (HP:0001609)2.33994840
99Hypoplastic left heart (HP:0004383)2.33867716
100Autoamputation (HP:0001218)2.29939706
101Emphysema (HP:0002097)2.27687365
102Abnormality of secondary sexual hair (HP:0009888)2.24497112
103Abnormality of the axillary hair (HP:0100134)2.24497112
104Hypoplastic ischia (HP:0003175)2.23085199
105Tetany (HP:0001281)2.21255041
106Lower limb amyotrophy (HP:0007210)2.19474027
107Hyperkalemia (HP:0002153)2.18328238
108Papilloma (HP:0012740)2.15311032
109Verrucae (HP:0200043)2.15311032
110Papillary thyroid carcinoma (HP:0002895)2.14925204
111Scapular winging (HP:0003691)2.14220672
112Abnormality of the labia majora (HP:0012881)2.12652554
113Fine hair (HP:0002213)2.11726070
114Popliteal pterygium (HP:0009756)2.09275483
115Skin pits (HP:0100276)2.06491907
116Hyponatremia (HP:0002902)2.05687656
117Thickened nuchal skin fold (HP:0000474)2.05554218
118Short palpebral fissure (HP:0012745)2.05385861
119Labial hypoplasia (HP:0000066)2.02082254
120Abnormality of potassium homeostasis (HP:0011042)2.00360487
121Oral leukoplakia (HP:0002745)12.4305977
122Absent hair (HP:0002298)1.97995318
123Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.97599267
124Abnormality of the ischium (HP:0003174)1.95656811
125Low posterior hairline (HP:0002162)1.95644969
126Foot dorsiflexor weakness (HP:0009027)1.95228917
127Shoulder girdle muscle weakness (HP:0003547)1.95188740
128Seborrheic dermatitis (HP:0001051)1.94007028
129Nasal speech (HP:0001611)1.91974123
130Amblyopia (HP:0000646)1.91696979
131Thyroiditis (HP:0100646)1.90897113
132Thick nail (HP:0001805)1.90205262
133Melanocytic nevus (HP:0000995)1.89988233
134Woolly hair (HP:0002224)1.89518503
135Pelvic girdle muscle weakness (HP:0003749)1.89358560
136Adrenal overactivity (HP:0002717)1.88358421
137Wrist flexion contracture (HP:0001239)1.86947668
138Exotropia (HP:0000577)1.86395526
139Muscular dystrophy (HP:0003560)1.85164989
140Hypertensive crisis (HP:0100735)1.84782675
141Ectropion (HP:0000656)1.84684818
142Corneal erosion (HP:0200020)1.83550142
143Hypoplastic female external genitalia (HP:0012815)1.83349699
144Coarse hair (HP:0002208)1.81027164
145Abnormality of the hip-girdle musculature (HP:0001445)1.80347724
146Abnormality of the musculature of the pelvis (HP:0001469)1.80347724
147Achilles tendon contracture (HP:0001771)1.79101752
148Ulnar deviation of finger (HP:0009465)1.78939809
149Abnormal blistering of the skin (HP:0008066)1.78328646
150Long clavicles (HP:0000890)1.77860222
151Increased circulating renin level (HP:0000848)1.76631101
152Severe combined immunodeficiency (HP:0004430)1.75771649
153Acne (HP:0001061)1.75737883
154Abnormality of the foot musculature (HP:0001436)1.75024481
155Delusions (HP:0000746)1.74763225
156Palmoplantar keratoderma (HP:0000982)1.72914917
157Spinal rigidity (HP:0003306)1.72319788
158Dialeptic seizures (HP:0011146)1.71311796
159Abnormality of the gallbladder (HP:0005264)1.71009787
160Abnormality of the Achilles tendon (HP:0005109)1.70963425
161Curly hair (HP:0002212)1.70814257
162Hypohidrosis (HP:0000966)1.70690654
163Gout (HP:0001997)1.68832960
164Abnormality of the shoulder girdle musculature (HP:0001435)1.68178177
165Metatarsus adductus (HP:0001840)1.67545917
166Hypoplastic heart (HP:0001961)1.67441781
167Obstructive sleep apnea (HP:0002870)1.67392876
168Advanced eruption of teeth (HP:0006288)1.66689866
169Mildly elevated creatine phosphokinase (HP:0008180)1.64309884
170Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.64267393
171Alkalosis (HP:0001948)1.63159807
172Split foot (HP:0001839)1.62922701
173Abnormality of sodium homeostasis (HP:0010931)1.61613143
174Sudden death (HP:0001699)1.58021171
175Onycholysis (HP:0001806)1.57083044
176Stenosis of the external auditory canal (HP:0000402)1.56478087
177Proximal amyotrophy (HP:0007126)1.55701408
178Asthma (HP:0002099)1.55680757
179Aplasia/Hypoplasia of the tongue (HP:0010295)1.55612789
180Hypokalemia (HP:0002900)1.52591272
181Choroideremia (HP:0001139)1.50162938
182Webbed neck (HP:0000465)1.49330137
183Lymphedema (HP:0001004)1.48045711
184Dry skin (HP:0000958)1.43116006
185Bronchitis (HP:0012387)1.41287745
186Abnormality of the labia (HP:0000058)1.41286377

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CG4.55543409
2OBSCN3.50824179
3CAMK1D3.45262816
4TRIB33.10524793
5STK392.81786274
6CAMK1G2.80142181
7PHKG12.79272509
8PHKG22.79272509
9NEK12.57176894
10MAP2K32.38336760
11SGK32.30372846
12SGK22.27625390
13PDK42.26853549
14PDK32.26853549
15STK242.23261274
16TIE12.13035882
17TTN10.4994693
18PINK11.86561844
19SGK4941.86017190
20SGK2231.86017190
21MARK21.77865325
22DMPK1.64255598
23MAPKAPK31.59039329
24PKN21.57138657
25PDK21.54469728
26BCR1.42727199
27FER1.34653003
28BCKDK1.31439538
29MAP3K31.22895481
30LRRK21.21465955
31RIPK11.12276488
32MAP2K41.11236627
33MAP3K71.08254533
34PDGFRB1.08232787
35TAOK11.06297196
36NME10.98998207
37MAPK120.98371189
38EPHB10.92451501
39TGFBR20.92040949
40PTK60.90986400
41EPHA20.90388581
42KSR20.88471906
43CDK120.88216429
44IRAK10.85743958
45STK30.82511135
46ERBB30.81561121
47STK380.79699446
48MAP3K120.79129975
49LIMK10.76769002
50MAP3K110.76648879
51PRKD10.76549700
52ICK0.73901331
53TRPM70.73779814
54MAP2K60.73305934
55MAP3K90.72393550
56RPS6KB10.72243026
57ERN10.71833579
58MAP3K20.71555583
59RPS6KB20.69027981
60AKT30.65268517
61CHUK0.64862113
62MTOR0.64278029
63SIK30.63499593
64EPHB20.63335419
65DDR20.63314437
66IKBKE0.63311702
67PIK3CA0.63160531
68IRAK20.62542664
69MAPK110.59135316
70PDGFRA0.59133877
71HIPK20.56394868
72CAMK2A0.56269737
73CDK90.55209890
74RPS6KA20.54414308
75IRAK40.51849591
76PRKCH0.50535790
77MST1R0.50529108
78PAK40.50374095
79PRKD20.49944141
80EEF2K0.49776899
81OXSR10.49720859
82NEK20.49375419
83ILK0.48313611
84PAK60.47666072
85LATS20.47095723
86FGFR20.46935338
87BMX0.46281399
88FGFR30.46034671
89MAP3K10.44823664
90PDPK10.43980765
91MAP3K40.41568985
92CAMK40.40529525
93MAP2K10.39916426
94AURKB0.39724137
95ROCK20.37150876
96MAP3K60.37085691
97GRK60.36047566
98MELK0.35597756
99CAMK2G0.35584818
100PAK30.35338146
101PDK10.35014596
102LATS10.34465650
103ZAP700.34121843
104SIK10.34067007
105WNK40.33240458
106FGFR40.32828597
107DAPK20.32654483
108RET0.32378676
109SGK10.31153319
110MAPK10.30765029
111NTRK10.30037764
112FGR0.29864841
113CSK0.29773099
114MAPKAPK50.29692741
115PKN10.29379869
116FGFR10.29081828
117ATM0.28183862
118AKT10.27796872
119TBK10.27683233
120DYRK1B0.27458729
121CDK30.26562573
122RPS6KA10.26400263
123ROCK10.26056853
124MET0.25299923
125PAK20.24667826
126STK40.24327570
127MAPKAPK20.24314782
128WNK10.23916224
129STK38L0.23803883
130MAPK30.23354470
131CAMK10.23311338
132STK100.23248497
133AKT20.23156068
134PRKD30.22468270
135CDC42BPA0.21854690
136MAPK70.21720510
137PRKACA0.21344095
138PRKAA20.21020201
139MST40.19714140
140RPS6KA30.18985971
141ITK0.18927262
142PRKCZ0.18870591
143PRKAA10.18796551
144FYN0.18557918
145TGFBR10.18069884
146PRKACB0.17925834
147SCYL20.17898549
148GSK3B0.17754110
149PRKG10.17353230
150MAPK40.17344780
151GSK3A0.16180750
152KDR0.15770581
153EPHA30.14985819
154PTK2B0.14568085
155TYRO30.14521027
156PRKACG0.14517329
157PTK20.14262124
158TESK10.13785642
159SRC0.13317427

Predicted pathways (KEGG)

RankGene SetZ-score
1Salivary secretion_Homo sapiens_hsa049704.26827075
2Circadian rhythm_Homo sapiens_hsa047104.21215855
3Phenylalanine metabolism_Homo sapiens_hsa003604.01834269
4Fat digestion and absorption_Homo sapiens_hsa049753.68197579
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.55167688
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.26710087
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.19142904
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.85427776
9Glycerolipid metabolism_Homo sapiens_hsa005612.43458414
10Histidine metabolism_Homo sapiens_hsa003402.32475591
11Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.21302942
12Notch signaling pathway_Homo sapiens_hsa043302.20075609
13Tyrosine metabolism_Homo sapiens_hsa003502.14323825
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09715970
15beta-Alanine metabolism_Homo sapiens_hsa004102.09647317
16Fatty acid degradation_Homo sapiens_hsa000711.89836016
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.77103807
18Acute myeloid leukemia_Homo sapiens_hsa052211.68854295
19Carbon metabolism_Homo sapiens_hsa012001.63031386
20Arginine biosynthesis_Homo sapiens_hsa002201.61950678
21Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.61504320
22Thyroid cancer_Homo sapiens_hsa052161.60797659
23Propanoate metabolism_Homo sapiens_hsa006401.60372669
24Chemical carcinogenesis_Homo sapiens_hsa052041.55414743
25Collecting duct acid secretion_Homo sapiens_hsa049661.45477032
26Cardiac muscle contraction_Homo sapiens_hsa042601.38404635
27Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.33242483
28Dilated cardiomyopathy_Homo sapiens_hsa054141.33120258
29Alzheimers disease_Homo sapiens_hsa050101.33031531
30Endocytosis_Homo sapiens_hsa041441.31289297
31Nitrogen metabolism_Homo sapiens_hsa009101.28971675
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25079974
33Vibrio cholerae infection_Homo sapiens_hsa051101.21091954
34Fatty acid metabolism_Homo sapiens_hsa012121.19930647
35Dorso-ventral axis formation_Homo sapiens_hsa043201.19172792
36Glucagon signaling pathway_Homo sapiens_hsa049221.16030645
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15784930
38Renin secretion_Homo sapiens_hsa049241.15657647
39Parkinsons disease_Homo sapiens_hsa050121.12788150
40Biosynthesis of amino acids_Homo sapiens_hsa012301.12766565
41Starch and sucrose metabolism_Homo sapiens_hsa005001.08465999
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.07746383
43Hepatitis C_Homo sapiens_hsa051601.06677739
44Pyruvate metabolism_Homo sapiens_hsa006201.05975344
45Glutathione metabolism_Homo sapiens_hsa004801.05573858
46Olfactory transduction_Homo sapiens_hsa047401.04164143
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01892733
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00362172
49Endometrial cancer_Homo sapiens_hsa052130.99101471
50Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98701723
51Lysine degradation_Homo sapiens_hsa003100.98020738
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97918232
53Hippo signaling pathway_Homo sapiens_hsa043900.97581698
54Chronic myeloid leukemia_Homo sapiens_hsa052200.97051046
55Gastric acid secretion_Homo sapiens_hsa049710.96618319
56Oxidative phosphorylation_Homo sapiens_hsa001900.95660348
57ErbB signaling pathway_Homo sapiens_hsa040120.92923705
58Prostate cancer_Homo sapiens_hsa052150.92822899
59GnRH signaling pathway_Homo sapiens_hsa049120.92695747
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.92674146
61Inositol phosphate metabolism_Homo sapiens_hsa005620.91411953
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91226394
63Toll-like receptor signaling pathway_Homo sapiens_hsa046200.89610245
64Oxytocin signaling pathway_Homo sapiens_hsa049210.87944845
65Axon guidance_Homo sapiens_hsa043600.86608760
66Bladder cancer_Homo sapiens_hsa052190.86481769
67FoxO signaling pathway_Homo sapiens_hsa040680.86471555
68Phototransduction_Homo sapiens_hsa047440.86097587
69Insulin signaling pathway_Homo sapiens_hsa049100.86018504
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85538060
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84515192
72Ras signaling pathway_Homo sapiens_hsa040140.84041594
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.83878631
74Influenza A_Homo sapiens_hsa051640.83341230
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.81688403
76Prolactin signaling pathway_Homo sapiens_hsa049170.80456033
77Choline metabolism in cancer_Homo sapiens_hsa052310.77927025
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77583818
79Pancreatic cancer_Homo sapiens_hsa052120.77064771
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76869536
81Butanoate metabolism_Homo sapiens_hsa006500.75924970
82Wnt signaling pathway_Homo sapiens_hsa043100.75866937
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75758389
84Arginine and proline metabolism_Homo sapiens_hsa003300.74691084
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73387213
86Insulin resistance_Homo sapiens_hsa049310.73366722
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73334795
88Pertussis_Homo sapiens_hsa051330.73015092
89Long-term potentiation_Homo sapiens_hsa047200.72432966
90Circadian entrainment_Homo sapiens_hsa047130.71865040
91Tryptophan metabolism_Homo sapiens_hsa003800.71168399
92Tight junction_Homo sapiens_hsa045300.70219247
93Shigellosis_Homo sapiens_hsa051310.70087441
94Glioma_Homo sapiens_hsa052140.69158765
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68492450
96Non-small cell lung cancer_Homo sapiens_hsa052230.67572984
97TGF-beta signaling pathway_Homo sapiens_hsa043500.67319671
98VEGF signaling pathway_Homo sapiens_hsa043700.66929775
99Calcium signaling pathway_Homo sapiens_hsa040200.66160392
100TNF signaling pathway_Homo sapiens_hsa046680.65941850
101Synaptic vesicle cycle_Homo sapiens_hsa047210.65674382
102Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65367792
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.63917295
104PPAR signaling pathway_Homo sapiens_hsa033200.62963880
105Focal adhesion_Homo sapiens_hsa045100.62665321
106Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61208689
107Retinol metabolism_Homo sapiens_hsa008300.59880304
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59586804
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.59582059
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59514374
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.59154805
112ECM-receptor interaction_Homo sapiens_hsa045120.58429673
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58383924
114MAPK signaling pathway_Homo sapiens_hsa040100.57537878
115Tuberculosis_Homo sapiens_hsa051520.57399032
116Fatty acid elongation_Homo sapiens_hsa000620.56102706
117Melanogenesis_Homo sapiens_hsa049160.55474406
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53348789
119Pathways in cancer_Homo sapiens_hsa052000.53153090
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.52399689
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50418334
122Linoleic acid metabolism_Homo sapiens_hsa005910.49613208
123Sulfur metabolism_Homo sapiens_hsa009200.49304749
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48469508
125T cell receptor signaling pathway_Homo sapiens_hsa046600.48121449
126Estrogen signaling pathway_Homo sapiens_hsa049150.46149841
127Hepatitis B_Homo sapiens_hsa051610.45464126
128MicroRNAs in cancer_Homo sapiens_hsa052060.45417138
129Fatty acid biosynthesis_Homo sapiens_hsa000610.45413037
130AMPK signaling pathway_Homo sapiens_hsa041520.44920488
131Chemokine signaling pathway_Homo sapiens_hsa040620.44199255
132Caffeine metabolism_Homo sapiens_hsa002320.44076859
133mTOR signaling pathway_Homo sapiens_hsa041500.43657574
134Pancreatic secretion_Homo sapiens_hsa049720.43491656
135Arachidonic acid metabolism_Homo sapiens_hsa005900.42275400
136Amoebiasis_Homo sapiens_hsa051460.41754789
137Long-term depression_Homo sapiens_hsa047300.41634338
138Platelet activation_Homo sapiens_hsa046110.41493572
139Phospholipase D signaling pathway_Homo sapiens_hsa040720.41334662
140Proteoglycans in cancer_Homo sapiens_hsa052050.41201027
141Bile secretion_Homo sapiens_hsa049760.40938846
142Taste transduction_Homo sapiens_hsa047420.40807546
143Hedgehog signaling pathway_Homo sapiens_hsa043400.39405924
144Jak-STAT signaling pathway_Homo sapiens_hsa046300.38175660
145Leukocyte transendothelial migration_Homo sapiens_hsa046700.36588415
146B cell receptor signaling pathway_Homo sapiens_hsa046620.36226404
147Huntingtons disease_Homo sapiens_hsa050160.36177537
148Amphetamine addiction_Homo sapiens_hsa050310.35927460
149AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33747922
150Renal cell carcinoma_Homo sapiens_hsa052110.31851598
151Complement and coagulation cascades_Homo sapiens_hsa046100.31291065
152Viral myocarditis_Homo sapiens_hsa054160.31189347
153Rap1 signaling pathway_Homo sapiens_hsa040150.31172507
154Pentose phosphate pathway_Homo sapiens_hsa000300.29863979
155Adherens junction_Homo sapiens_hsa045200.28836139
156HIF-1 signaling pathway_Homo sapiens_hsa040660.28331306
157Dopaminergic synapse_Homo sapiens_hsa047280.26124802
158Fructose and mannose metabolism_Homo sapiens_hsa000510.24815437
159Galactose metabolism_Homo sapiens_hsa000520.23225792
160Serotonergic synapse_Homo sapiens_hsa047260.22698034
161Neurotrophin signaling pathway_Homo sapiens_hsa047220.21834453
162Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21829494
163Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.19198243
164Salmonella infection_Homo sapiens_hsa051320.18243182

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