SPRY1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1somite development (GO:0061053)4.44632459
2axon extension involved in axon guidance (GO:0048846)4.33128416
3blood vessel maturation (GO:0001955)4.26488609
4surfactant homeostasis (GO:0043129)4.18863185
5neuronal stem cell maintenance (GO:0097150)4.10197365
6regulation of interleukin-12 biosynthetic process (GO:0045075)4.02841563
7endothelial cell chemotaxis (GO:0035767)3.92964222
8endothelial tube morphogenesis (GO:0061154)3.82906924
9morphogenesis of an endothelium (GO:0003159)3.82906924
10G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.76083162
11mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.75171315
12segment specification (GO:0007379)3.74726879
13lung lobe morphogenesis (GO:0060463)3.63548588
14positive regulation of endothelial cell apoptotic process (GO:2000353)3.61174710
15cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.55221655
16cell migration involved in sprouting angiogenesis (GO:0002042)3.53297752
17limb development (GO:0060173)3.50675576
18appendage development (GO:0048736)3.50675576
19regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.49410471
20vascular endothelial growth factor signaling pathway (GO:0038084)3.46151783
21respiratory tube development (GO:0030323)3.30121146
22mesodermal cell differentiation (GO:0048333)3.26829198
23cell proliferation in forebrain (GO:0021846)3.26581879
24epithelial cell differentiation involved in prostate gland development (GO:0060742)3.25800971
25positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.24354495
26metanephric mesenchyme development (GO:0072075)3.20551637
27lymph vessel development (GO:0001945)3.20155217
28protein heterotrimerization (GO:0070208)3.17009214
29regulation of non-canonical Wnt signaling pathway (GO:2000050)3.15891991
30tongue development (GO:0043586)3.15004623
31regulation of immunoglobulin secretion (GO:0051023)3.11649738
32regulation of gastrulation (GO:0010470)3.05540360
33retinal ganglion cell axon guidance (GO:0031290)3.02934373
34chemical homeostasis within a tissue (GO:0048875)3.02524063
35blood vessel endothelial cell migration (GO:0043534)3.01632399
36nonmotile primary cilium assembly (GO:0035058)3.00478344
37spinal cord development (GO:0021510)2.97685840
38negative regulation of cell fate specification (GO:0009996)2.96931894
39hippo signaling (GO:0035329)2.96468573
40calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.95286768
41negative regulation of fatty acid transport (GO:2000192)2.94631348
42pyrimidine nucleobase catabolic process (GO:0006208)2.94492074
43vasculature development (GO:0001944)2.93018162
44radial glial cell differentiation (GO:0060019)2.92486085
45organ formation (GO:0048645)2.91153260
46intraciliary transport (GO:0042073)2.90123184
47positive regulation of metanephros development (GO:0072216)2.83955115
48epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.83234530
49camera-type eye morphogenesis (GO:0048593)2.81830025
50nephron tubule development (GO:0072080)2.80649970
51hemidesmosome assembly (GO:0031581)2.80351011
52epithelial cell-cell adhesion (GO:0090136)2.79906496
53cardiac myofibril assembly (GO:0055003)2.79720996
54regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.79319387
55positive regulation of male gonad development (GO:2000020)2.79226991
56pattern specification involved in kidney development (GO:0061004)2.78294865
57regulation of metanephros development (GO:0072215)2.78230783
58response to nitrosative stress (GO:0051409)2.77002345
59positive thymic T cell selection (GO:0045059)2.76863430
60positive regulation of astrocyte differentiation (GO:0048711)2.75806598
61regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.75714078
62negative regulation of chondrocyte differentiation (GO:0032331)2.75570857
63cell proliferation involved in kidney development (GO:0072111)2.75019531
64regulation of cell proliferation involved in kidney development (GO:1901722)2.74341448
65regulation of cell fate commitment (GO:0010453)2.73711315
66regulation of axon guidance (GO:1902667)2.73628347
67growth hormone receptor signaling pathway (GO:0060396)2.71726514
68kidney mesenchyme development (GO:0072074)2.69625444
69germ cell migration (GO:0008354)2.69339564
70positive regulation of gastrulation (GO:2000543)2.69282188
71head development (GO:0060322)2.68985905
72behavioral response to nicotine (GO:0035095)2.68918878
73regulation of hippo signaling (GO:0035330)2.68440853
74positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.68203733
75neural crest cell development (GO:0014032)2.67720475
76regulation of SMAD protein import into nucleus (GO:0060390)2.66386546
77endodermal cell differentiation (GO:0035987)2.66124560
78negative regulation of axon guidance (GO:1902668)2.65695061
79olfactory bulb development (GO:0021772)2.65137851
80planar cell polarity pathway involved in neural tube closure (GO:0090179)2.65031296
81adult heart development (GO:0007512)2.64472757
82limb bud formation (GO:0060174)2.63289448
83establishment of epithelial cell polarity (GO:0090162)2.62589095
84tyrosine phosphorylation of STAT protein (GO:0007260)2.62015913
85short-term memory (GO:0007614)2.61956071
86regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.61768916
87outer ear morphogenesis (GO:0042473)2.61749187
88bone trabecula formation (GO:0060346)2.61647351
89cell-substrate junction assembly (GO:0007044)2.61635202
90nephron tubule morphogenesis (GO:0072078)2.60394345
91nephron epithelium morphogenesis (GO:0072088)2.60394345
92cerebral cortex radially oriented cell migration (GO:0021799)2.59979685
93establishment of tissue polarity (GO:0007164)2.59476920
94establishment of planar polarity (GO:0001736)2.59476920
95postsynaptic membrane organization (GO:0001941)2.58433154
96left/right pattern formation (GO:0060972)2.58228055
97mesenchymal cell development (GO:0014031)2.56760722
98middle ear morphogenesis (GO:0042474)2.56611907
99negative regulation of stress fiber assembly (GO:0051497)2.56462784
100lymphangiogenesis (GO:0001946)2.55845206
101nephron epithelium development (GO:0072009)2.55535782
102branching involved in salivary gland morphogenesis (GO:0060445)2.55347919
103regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.55343999
104* axis elongation (GO:0003401)2.54639296
105regulation of vitamin D biosynthetic process (GO:0060556)2.52984480
106regulation of smooth muscle cell differentiation (GO:0051150)2.52798964
107embryonic process involved in female pregnancy (GO:0060136)2.52023069
108aorta morphogenesis (GO:0035909)2.51964351
109mesenchyme morphogenesis (GO:0072132)2.51719417
110retina vasculature morphogenesis in camera-type eye (GO:0061299)2.51107746
111Notch signaling involved in heart development (GO:0061314)2.50875771
112regulation of endothelial cell differentiation (GO:0045601)2.50724950
113adherens junction assembly (GO:0034333)2.50614135
114epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.49051126
115hindlimb morphogenesis (GO:0035137)2.48659045
116regulation of cell fate specification (GO:0042659)2.48066117
117regulation of heart morphogenesis (GO:2000826)2.47873350
118regulation of mesoderm development (GO:2000380)2.46297606
119focal adhesion assembly (GO:0048041)2.46150967
120cell-substrate adherens junction assembly (GO:0007045)2.46150967
121positive regulation of mitochondrial fission (GO:0090141)2.45998048
122positive regulation of SMAD protein import into nucleus (GO:0060391)2.45736828
123lung vasculature development (GO:0060426)2.45128098
124otic vesicle formation (GO:0030916)2.44959812
125dorsal/ventral pattern formation (GO:0009953)2.44790714
126desmosome organization (GO:0002934)2.44732577
127regulation of chondrocyte differentiation (GO:0032330)2.43272860
128epithelial cilium movement (GO:0003351)2.42562115
129negative chemotaxis (GO:0050919)2.42250233
130cell differentiation involved in metanephros development (GO:0072202)2.41793568
131negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.41566776
132positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.41417024
133regulation of p38MAPK cascade (GO:1900744)2.40727629
134regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.40342436
135metanephric tubule development (GO:0072170)2.39920587
136metanephric nephron tubule development (GO:0072234)2.39920587
137regulation of somitogenesis (GO:0014807)2.39058304
138artery smooth muscle contraction (GO:0014824)2.38649962
139embryonic hemopoiesis (GO:0035162)2.38120069
140regulation of axon extension involved in axon guidance (GO:0048841)2.37989863
141renal tubule development (GO:0061326)2.37807294
142presynaptic membrane assembly (GO:0097105)2.37466349
143positive regulation of cartilage development (GO:0061036)2.36487499
144regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.36462587
145positive regulation of endothelial cell differentiation (GO:0045603)2.36387635
146muscle filament sliding (GO:0030049)2.35495266
147actin-myosin filament sliding (GO:0033275)2.35495266
148regulation of isotype switching to IgG isotypes (GO:0048302)2.35032400
149positive regulation of epithelial to mesenchymal transition (GO:0010718)2.34788758
150negative regulation of catenin import into nucleus (GO:0035414)2.34737411
151negative regulation of translation, ncRNA-mediated (GO:0040033)2.34733631
152regulation of translation, ncRNA-mediated (GO:0045974)2.34733631
153negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.34733631
154atrioventricular valve morphogenesis (GO:0003181)2.34571658
155basement membrane organization (GO:0071711)2.34450014
156lateral sprouting from an epithelium (GO:0060601)2.34421120
157endothelial cell differentiation (GO:0045446)2.34352023
158positive regulation of tolerance induction (GO:0002645)2.33952229
159heart trabecula formation (GO:0060347)2.33864594
160lung-associated mesenchyme development (GO:0060484)2.33564983
161paraxial mesoderm development (GO:0048339)2.32899373
162polarized epithelial cell differentiation (GO:0030859)2.32462687
163renal filtration (GO:0097205)2.32168378
164positive regulation of chondrocyte differentiation (GO:0032332)2.31968021
165cellular response to growth hormone stimulus (GO:0071378)2.31680836
166neuron fate determination (GO:0048664)2.30692463
167negative regulation of oligodendrocyte differentiation (GO:0048715)2.30574663
168renal tubule morphogenesis (GO:0061333)2.30526218
169regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.29954095
170negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.29692509
171cell surface receptor signaling pathway involved in heart development (GO:0061311)2.29487985
172inner ear morphogenesis (GO:0042472)2.29414869
173CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.28117358
174cellular response to BMP stimulus (GO:0071773)2.27996172
175response to BMP (GO:0071772)2.27996172
176regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.27537152
177cell proliferation involved in metanephros development (GO:0072203)2.27497547
178negative regulation of alcohol biosynthetic process (GO:1902931)2.27414757
179somatic stem cell division (GO:0048103)2.27074833
180trabecula formation (GO:0060343)2.27019758
181negative regulation of cartilage development (GO:0061037)2.26927084
182regulation of gamma-delta T cell differentiation (GO:0045586)2.26879223
183embryonic cranial skeleton morphogenesis (GO:0048701)2.26775097
184endothelial cell morphogenesis (GO:0001886)2.26280993
185neuron projection extension involved in neuron projection guidance (GO:1902284)2.25497946

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.29683271
2EZH2_22144423_ChIP-Seq_EOC_Human5.29906613
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.17690445
4RBPJ_22232070_ChIP-Seq_NCS_Mouse4.09235215
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.75999583
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.65890318
7TRIM28_21343339_ChIP-Seq_HEK293_Human3.55172135
8CLOCK_20551151_ChIP-Seq_293T_Human3.25656045
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.18629200
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.02071782
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.77388673
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.60788414
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.54196080
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.51819141
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.36192102
16CBX2_27304074_Chip-Seq_ESCs_Mouse2.31663393
17* HIF1A_21447827_ChIP-Seq_MCF-7_Human2.28906730
18ELK3_25401928_ChIP-Seq_HUVEC_Human2.23386475
19ZNF263_19887448_ChIP-Seq_K562_Human2.23316225
20POU5F1_16153702_ChIP-ChIP_HESCs_Human2.12472190
21MYC_22102868_ChIP-Seq_BL_Human2.09887414
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06570516
23* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.03110650
24EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.02958589
25ESR1_21235772_ChIP-Seq_MCF-7_Human1.99770524
26IGF1R_20145208_ChIP-Seq_DFB_Human1.99555912
27* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.98091435
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.97633022
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.89364865
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.89364865
31ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.88228162
32* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.88052564
33* KDM2B_26808549_Chip-Seq_DND41_Human1.86919131
34FUS_26573619_Chip-Seq_HEK293_Human1.86591832
35RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.86191833
36RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.85642496
37* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.85607137
38TCF7_22412390_ChIP-Seq_EML_Mouse1.85461580
39TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.85230270
40SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.84960190
41KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.84676250
42KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.84676250
43KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.84676250
44RNF2_27304074_Chip-Seq_NSC_Mouse1.84033538
45ZNF274_21170338_ChIP-Seq_K562_Hela1.83744595
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80452935
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.80058472
48JARID2_20064375_ChIP-Seq_MESCs_Mouse1.79389789
49VDR_22108803_ChIP-Seq_LS180_Human1.78227091
50SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.77830602
51JARID2_20075857_ChIP-Seq_MESCs_Mouse1.76289697
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.75502372
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.75356553
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.74553744
55RNF2_27304074_Chip-Seq_ESCs_Mouse1.73219747
56RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.72511199
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.72435678
58CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.71357550
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.70247873
60ESR1_20079471_ChIP-ChIP_T-47D_Human1.69192482
61SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.68786589
62* KDM2B_26808549_Chip-Seq_JURKAT_Human1.66702100
63SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.65843635
64SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.65843635
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.65819002
66* RACK7_27058665_Chip-Seq_MCF-7_Human1.64742696
67NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.64143093
68* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63572218
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60544746
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.60466298
71FOXO3_23340844_ChIP-Seq_DLD1_Human1.59280747
72PPAR_26484153_Chip-Seq_NCI-H1993_Human1.58953901
73SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.58209734
74EZH2_27294783_Chip-Seq_ESCs_Mouse1.56607454
75RUNX_20019798_ChIP-Seq_JUKART_Human1.56444499
76WT1_19549856_ChIP-ChIP_CCG9911_Human1.56314007
77P300_19829295_ChIP-Seq_ESCs_Human1.55865897
78TP63_19390658_ChIP-ChIP_HaCaT_Human1.53194083
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52819410
80PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.52525516
81* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.51984291
82UBF1/2_26484160_Chip-Seq_HMECs_Human1.51235663
83* ATF3_27146783_Chip-Seq_COLON_Human1.49814682
84GBX2_23144817_ChIP-Seq_PC3_Human1.49236425
85* RUNX1_27514584_Chip-Seq_MCF-7_Human1.48803167
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.46523743
87* RING1B_27294783_Chip-Seq_ESCs_Mouse1.46239510
88EP300_21415370_ChIP-Seq_HL-1_Mouse1.43590852
89* RING1B_27294783_Chip-Seq_NPCs_Mouse1.42205449
90TBX20_22080862_ChIP-Seq_HEART_Mouse1.42203430
91TBX20_22328084_ChIP-Seq_HEART_Mouse1.42203430
92* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.40597980
93P300_27058665_Chip-Seq_ZR-75-30cells_Human1.38784274
94SOX9_24532713_ChIP-Seq_HFSC_Mouse1.38699080
95STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.38530901
96TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.38351240
97ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38303791
98SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.38048962
99SALL1_21062744_ChIP-ChIP_HESCs_Human1.36165284
100ZFP281_18757296_ChIP-ChIP_E14_Mouse1.35300729
101TAF15_26573619_Chip-Seq_HEK293_Human1.35293847
102CJUN_26792858_Chip-Seq_BT549_Human1.34901504
103IRF1_19129219_ChIP-ChIP_H3396_Human1.33076585
104ZFP281_27345836_Chip-Seq_ESCs_Mouse1.32490471
105CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.32082514
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.30965726
107SMAD3_21741376_ChIP-Seq_EPCs_Human1.29752935
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29330570
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29330570
110MAF_26560356_Chip-Seq_TH1_Human1.28685697
111PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28603038
112HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.28589098
113SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28023157
114GATA2_21666600_ChIP-Seq_HMVEC_Human1.27674286
115TCF3_18692474_ChIP-Seq_MEFs_Mouse1.27421110
116CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27089094
117* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.26693787
118SOX2_16153702_ChIP-ChIP_HESCs_Human1.25612408
119SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.25531163
120TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25119558
121DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.24711379
122EWS_26573619_Chip-Seq_HEK293_Human1.24643861
123TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22911217
124GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22582051
125* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22460705
126* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22044291
127NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21187749
128BRD4_25478319_ChIP-Seq_HGPS_Human1.21001253
129NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20505505
130* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20124821
131STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19704603
132KDM2B_26808549_Chip-Seq_K562_Human1.18555946
133* ISL1_27105846_Chip-Seq_CPCs_Mouse1.16966049
134CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16173766
135* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15377961
136ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14599821
137CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14147461
138UTX_26944678_Chip-Seq_JUKART_Human1.14095752
139FOXM1_23109430_ChIP-Seq_U2OS_Human1.13918078
140TBX3_20139965_ChIP-Seq_ESCs_Mouse1.13287271
141SMAD4_21799915_ChIP-Seq_A2780_Human1.12771368
142* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12568668
143* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12482040
144TBX3_20139965_ChIP-Seq_MESCs_Mouse1.11874975
145* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11638043
146NCOR1_26117541_ChIP-Seq_K562_Human1.11555134
147SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10798681
148NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08826902
149* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.08385749
150* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07401254
151TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07114828
152MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07026782
153JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06662666
154AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05678322
155FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05026333
156POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04843687
157* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03646713
158TP53_20018659_ChIP-ChIP_R1E_Mouse1.03282379
159ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03069513
160VDR_21846776_ChIP-Seq_THP-1_Human1.02771869
161POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.02596825
162AR_21572438_ChIP-Seq_LNCaP_Human1.02089576
163RXR_22108803_ChIP-Seq_LS180_Human1.01839923
164ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01574843
165TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01115555
166TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00885173
167UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00463115
168* NANOG_16153702_ChIP-ChIP_HESCs_Human1.00355129
169OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00212553
170* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99884330
171FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.99330602
172* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99227160
173* CDX2_20551321_ChIP-Seq_CACO-2_Human0.99210787
174AR_25329375_ChIP-Seq_VCAP_Human0.99183961
175HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98503221
176* RUNX2_22187159_ChIP-Seq_PCA_Human0.97808495
177TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97737559
178* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97084915
179THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96784751
180* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95583082
181SOX9_26525672_Chip-Seq_HEART_Mouse0.95345613
182GATA6_25053715_ChIP-Seq_YYC3_Human0.94883658

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.56639920
2MP0006292_abnormal_olfactory_placode3.53153602
3MP0001958_emphysema3.09172635
4MP0003300_gastrointestinal_ulcer2.91922957
5MP0003122_maternal_imprinting2.88627513
6MP0004272_abnormal_basement_membrane2.81569141
7MP0005275_abnormal_skin_tensile2.71121965
8MP0010368_abnormal_lymphatic_system2.61438103
9MP0000049_abnormal_middle_ear2.60229834
10MP0002653_abnormal_ependyma_morphology2.59542931
11MP0005503_abnormal_tendon_morphology2.43063235
12MP0004133_heterotaxia2.28969174
13MP0003136_yellow_coat_color2.25197851
14MP0003705_abnormal_hypodermis_morpholog2.16630241
15MP0003941_abnormal_skin_development2.11031995
16MP0008789_abnormal_olfactory_epithelium2.06804863
17MP0003279_aneurysm2.04229569
18MP0004782_abnormal_surfactant_physiolog2.00187645
19MP0001293_anophthalmia1.88915568
20MP0001879_abnormal_lymphatic_vessel1.86202754
21MP0009379_abnormal_foot_pigmentation1.85769432
22MP0002233_abnormal_nose_morphology1.84928035
23MP0002938_white_spotting1.79564737
24MP0003724_increased_susceptibility_to1.79531634
25MP0000778_abnormal_nervous_system1.78673066
26MP0006054_spinal_hemorrhage1.76605781
27MP0005623_abnormal_meninges_morphology1.68998766
28MP0000733_abnormal_muscle_development1.65818736
29MP0002060_abnormal_skin_morphology1.64988830
30MP0006072_abnormal_retinal_apoptosis1.63775126
31MP0010030_abnormal_orbit_morphology1.63416740
32MP0010352_gastrointestinal_tract_polyps1.63349857
33MP0009278_abnormal_bone_marrow1.60739111
34MP0003283_abnormal_digestive_organ1.59570910
35MP0003567_abnormal_fetal_cardiomyocyte1.58368492
36MP0003566_abnormal_cell_adhesion1.54211735
37MP0004084_abnormal_cardiac_muscle1.53061032
38MP0002877_abnormal_melanocyte_morpholog1.50250973
39MP0002166_altered_tumor_susceptibility1.50214645
40MP0000767_abnormal_smooth_muscle1.49034694
41MP0003763_abnormal_thymus_physiology1.47826030
42MP0002249_abnormal_larynx_morphology1.47787847
43MP0001286_abnormal_eye_development1.47751379
44MP0005076_abnormal_cell_differentiation1.47692479
45MP0003115_abnormal_respiratory_system1.46579998
46MP0002638_abnormal_pupillary_reflex1.44603810
47MP0005508_abnormal_skeleton_morphology1.41958104
48MP0001299_abnormal_eye_distance/1.41025999
49MP0003755_abnormal_palate_morphology1.39830027
50MP0003937_abnormal_limbs/digits/tail_de1.39419519
51MP0003828_pulmonary_edema1.38796797
52MP0009250_abnormal_appendicular_skeleto1.38063832
53MP0003878_abnormal_ear_physiology1.35671977
54MP0005377_hearing/vestibular/ear_phenot1.35671977
55MP0005023_abnormal_wound_healing1.35263934
56MP0005499_abnormal_olfactory_system1.34721101
57MP0005394_taste/olfaction_phenotype1.34721101
58MP0002116_abnormal_craniofacial_bone1.33140876
59MP0001485_abnormal_pinna_reflex1.32326612
60MP0003385_abnormal_body_wall1.31511943
61MP0000026_abnormal_inner_ear1.31432942
62MP0003303_peritoneal_inflammation1.31026468
63MP0004808_abnormal_hematopoietic_stem1.30164772
64MP0002127_abnormal_cardiovascular_syste1.30145095
65MP0009053_abnormal_anal_canal1.29921709
66MP0003119_abnormal_digestive_system1.29824157
67MP0003938_abnormal_ear_development1.28828300
68MP0000537_abnormal_urethra_morphology1.28487146
69* MP0000534_abnormal_ureter_morphology1.28222920
70MP0000465_gastrointestinal_hemorrhage1.26398115
71MP0003121_genomic_imprinting1.25775901
72* MP0003942_abnormal_urinary_system1.22473820
73MP0002108_abnormal_muscle_morphology1.22343736
74MP0002925_abnormal_cardiovascular_devel1.20388088
75MP0004215_abnormal_myocardial_fiber1.18778002
76MP0005171_absent_coat_pigmentation1.16411159
77MP0001984_abnormal_olfaction1.16402064
78MP0006276_abnormal_autonomic_nervous1.14442777
79MP0000762_abnormal_tongue_morphology1.12046688
80MP0002006_tumorigenesis1.11807169
81MP0002009_preneoplasia1.11469126
82MP0008775_abnormal_heart_ventricle1.10614888
83MP0000750_abnormal_muscle_regeneration1.08493409
84MP0002111_abnormal_tail_morphology1.08420752
85MP0003453_abnormal_keratinocyte_physiol1.08052529
86MP0006138_congestive_heart_failure1.07977832
87MP0000428_abnormal_craniofacial_morphol1.06698071
88MP0002133_abnormal_respiratory_system1.05637358
89MP0005388_respiratory_system_phenotype1.05637358
90MP0002295_abnormal_pulmonary_circulatio1.05271582
91MP0010630_abnormal_cardiac_muscle1.04366487
92MP0001851_eye_inflammation1.03532175
93MP0001915_intracranial_hemorrhage1.02866456
94MP0002128_abnormal_blood_circulation1.02650576
95MP0004185_abnormal_adipocyte_glucose1.02258169
96MP0000383_abnormal_hair_follicle1.01780730
97MP0005253_abnormal_eye_physiology1.01454842
98MP0002796_impaired_skin_barrier1.00853242
99MP0005369_muscle_phenotype1.00730375
100MP0002282_abnormal_trachea_morphology0.98809490
101MP0002752_abnormal_somatic_nervous0.97407941
102MP0005670_abnormal_white_adipose0.97262898
103MP0002234_abnormal_pharynx_morphology0.96987862
104MP0000467_abnormal_esophagus_morphology0.96791285
105MP0001502_abnormal_circadian_rhythm0.96483375
106MP0001614_abnormal_blood_vessel0.96084638
107MP0003646_muscle_fatigue0.96034681
108MP0001175_abnormal_lung_morphology0.95942985
109MP0002109_abnormal_limb_morphology0.95496307
110MP0008961_abnormal_basal_metabolism0.95349753
111MP0004885_abnormal_endolymph0.94959599
112MP0009384_cardiac_valve_regurgitation0.94608612
113MP0003091_abnormal_cell_migration0.93827789
114MP0003011_delayed_dark_adaptation0.93584823
115MP0002933_joint_inflammation0.92971761
116MP0005167_abnormal_blood-brain_barrier0.92767074
117MP0000631_abnormal_neuroendocrine_gland0.92578611
118MP0005195_abnormal_posterior_eye0.92447741
119MP0005391_vision/eye_phenotype0.91932238
120MP0005257_abnormal_intraocular_pressure0.90284096
121MP0005620_abnormal_muscle_contractility0.89714856
122MP0000685_abnormal_immune_system0.89520513
123MP0000647_abnormal_sebaceous_gland0.89343076
124MP0002088_abnormal_embryonic_growth/wei0.88650636
125MP0002932_abnormal_joint_morphology0.88631968
126MP0001243_abnormal_dermal_layer0.88349327
127MP0002405_respiratory_system_inflammati0.87435637
128MP0000163_abnormal_cartilage_morphology0.87337249
129MP0001545_abnormal_hematopoietic_system0.87208538
130MP0005397_hematopoietic_system_phenotyp0.87208538
131MP0003935_abnormal_craniofacial_develop0.86770656
132MP0001853_heart_inflammation0.85669097
133MP0003984_embryonic_growth_retardation0.85549647
134MP0010678_abnormal_skin_adnexa0.85200442
135MP0003861_abnormal_nervous_system0.84186300
136MP0008004_abnormal_stomach_pH0.84105044
137MP0000751_myopathy0.83988712
138MP0005390_skeleton_phenotype0.83795795
139MP0005248_abnormal_Harderian_gland0.83738824
140MP0005501_abnormal_skin_physiology0.83708116
141MP0010234_abnormal_vibrissa_follicle0.83604309
142MP0002086_abnormal_extraembryonic_tissu0.83450947
143MP0004197_abnormal_fetal_growth/weight/0.83287670
144MP0000432_abnormal_head_morphology0.83273570
145MP0004087_abnormal_muscle_fiber0.83115134
146MP0000566_synostosis0.82786861
147MP0001544_abnormal_cardiovascular_syste0.82351772
148MP0005385_cardiovascular_system_phenoty0.82351772
149MP0004145_abnormal_muscle_electrophysio0.81770274
150MP0001177_atelectasis0.81691135
151MP0002092_abnormal_eye_morphology0.81576740
152MP0008995_early_reproductive_senescence0.81189410
153MP0000266_abnormal_heart_morphology0.81057671
154MP0003436_decreased_susceptibility_to0.78954967
155MP0001963_abnormal_hearing_physiology0.78675537
156MP0003448_altered_tumor_morphology0.78665872
157MP0002106_abnormal_muscle_physiology0.78223809
158MP0002132_abnormal_respiratory_system0.77221446
159MP0002697_abnormal_eye_size0.76837367
160MP0001216_abnormal_epidermal_layer0.76088402
161MP0001784_abnormal_fluid_regulation0.75073208
162MP0001340_abnormal_eyelid_morphology0.74948709
163MP0002837_dystrophic_cardiac_calcinosis0.74720019
164MP0002184_abnormal_innervation0.74685441
165MP0000579_abnormal_nail_morphology0.74422380

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.46655614
2Broad metatarsal (HP:0001783)4.43146852
3Shallow orbits (HP:0000586)4.17080576
4Ankle contracture (HP:0006466)3.92941057
5Premature rupture of membranes (HP:0001788)3.59912099
6Cerebral aneurysm (HP:0004944)3.54855601
7Aortic dissection (HP:0002647)3.28028877
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.25288399
9Short 4th metacarpal (HP:0010044)3.25288399
10Aortic aneurysm (HP:0004942)3.25275789
11True hermaphroditism (HP:0010459)3.19445759
12Septo-optic dysplasia (HP:0100842)3.08780735
13Abnormality of skeletal muscle fiber size (HP:0012084)3.01840604
14Colon cancer (HP:0003003)2.85102459
15Distal lower limb amyotrophy (HP:0008944)2.82409393
16Increased density of long bones (HP:0006392)2.82389064
17Increased connective tissue (HP:0009025)2.80683900
18Rectal prolapse (HP:0002035)2.78245783
19Type 1 muscle fiber predominance (HP:0003803)2.74655139
20Anophthalmia (HP:0000528)2.72147996
21Pancreatic fibrosis (HP:0100732)2.69685724
22Atrophic scars (HP:0001075)2.66787177
23Bladder diverticulum (HP:0000015)2.65603037
24Mitral valve prolapse (HP:0001634)2.65292616
25Distal lower limb muscle weakness (HP:0009053)2.64108116
26Abnormality of the 4th metacarpal (HP:0010012)2.63713502
27Rib fusion (HP:0000902)2.62598963
28Nephronophthisis (HP:0000090)2.60429796
29Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.56630675
30Nemaline bodies (HP:0003798)2.56203200
31Polycythemia (HP:0001901)2.53932781
32Interstitial pulmonary disease (HP:0006530)2.53407205
33Aplasia/Hypoplasia of the breasts (HP:0010311)2.49635799
34Peritonitis (HP:0002586)2.45951184
35Dilatation of the ascending aorta (HP:0005111)2.44791343
36Breast aplasia (HP:0100783)2.43893376
37Abnormality of the ischium (HP:0003174)2.42619801
38Soft skin (HP:0000977)2.41706868
39Exercise-induced muscle cramps (HP:0003710)2.39807194
40Muscle fiber inclusion bodies (HP:0100299)2.37636274
41Gait imbalance (HP:0002141)2.36620490
42Molar tooth sign on MRI (HP:0002419)2.36372615
43Abnormality of midbrain morphology (HP:0002418)2.36372615
44Medial flaring of the eyebrow (HP:0010747)2.35740233
45Limb-girdle muscle atrophy (HP:0003797)2.35540067
46Muscle fiber splitting (HP:0003555)2.35157776
47Pancreatic cysts (HP:0001737)2.34702359
48Persistence of primary teeth (HP:0006335)2.31957611
49Fibular hypoplasia (HP:0003038)2.31543788
50Congenital primary aphakia (HP:0007707)2.31349161
51Maternal diabetes (HP:0009800)2.30915081
52Round ear (HP:0100830)2.29230092
53Vascular tortuosity (HP:0004948)2.27871218
54Abnormality of the renal medulla (HP:0100957)2.27098918
55Milia (HP:0001056)2.26895637
56Calcaneovalgus deformity (HP:0001848)2.26871609
57Vaginal atresia (HP:0000148)2.25200059
58Hypoplastic ischia (HP:0003175)2.21480489
59Vitreoretinal degeneration (HP:0000655)2.20882137
60Aneurysm (HP:0002617)2.20631541
61Right ventricular cardiomyopathy (HP:0011663)2.20300131
62Abnormality of the peritoneum (HP:0002585)2.20051863
63Hyperglycinemia (HP:0002154)2.18462713
64Cutaneous melanoma (HP:0012056)2.18176344
65Increased variability in muscle fiber diameter (HP:0003557)2.18120720
66Hyperglycinuria (HP:0003108)2.17765155
67Spinal rigidity (HP:0003306)2.17237797
68Genital tract atresia (HP:0001827)2.15692931
69Arterial tortuosity (HP:0005116)2.12524488
70Mildly elevated creatine phosphokinase (HP:0008180)2.12159279
71Neonatal short-limb short stature (HP:0008921)2.12044257
72Postaxial foot polydactyly (HP:0001830)2.11674414
73Renal dysplasia (HP:0000110)2.11462979
74Camptodactyly of toe (HP:0001836)2.11384354
75Congenital hepatic fibrosis (HP:0002612)2.10945493
76Bile duct proliferation (HP:0001408)2.10490907
77Abnormal biliary tract physiology (HP:0012439)2.10490907
78Cystic liver disease (HP:0006706)2.10364433
79Supernumerary spleens (HP:0009799)2.08146784
80Deformed tarsal bones (HP:0008119)2.05841973
81Short tibia (HP:0005736)2.04811445
82Median cleft lip (HP:0000161)2.04298308
83Rocker bottom foot (HP:0001838)2.04075210
84Pulmonary artery stenosis (HP:0004415)2.03909957
85Hypoplasia of the ulna (HP:0003022)2.03890525
86Lower limb amyotrophy (HP:0007210)2.03754409
87Cutaneous finger syndactyly (HP:0010554)2.01819508
88Esophageal varix (HP:0002040)2.01756033
89Anencephaly (HP:0002323)2.01677216
90Nephrogenic diabetes insipidus (HP:0009806)2.00642334
91Disproportionate tall stature (HP:0001519)2.00329892
92Occipital encephalocele (HP:0002085)1.99407721
93Entropion (HP:0000621)1.98953219
94Supernumerary bones of the axial skeleton (HP:0009144)1.98002255
95Down-sloping shoulders (HP:0200021)1.97798081
96Cutaneous syndactyly (HP:0012725)1.97518742
97Aplasia/Hypoplasia of the fibula (HP:0006492)1.97377560
98Thin bony cortex (HP:0002753)1.96844033
99Wrist flexion contracture (HP:0001239)1.96675489
100Aplasia/Hypoplasia of the tibia (HP:0005772)1.96605706
101Hyporeflexia of lower limbs (HP:0002600)1.96346014
102Broad foot (HP:0001769)1.95771189
103Erectile abnormalities (HP:0100639)1.95706913
104Preaxial foot polydactyly (HP:0001841)1.95031147
105Renal hypoplasia (HP:0000089)1.94684706
106Aplasia/Hypoplasia of the tongue (HP:0010295)1.93650719
107Hematochezia (HP:0002573)1.92808136
108Follicular hyperkeratosis (HP:0007502)1.89686318
109Ulnar bowing (HP:0003031)1.89422907
110Fragile skin (HP:0001030)1.89136016
111Ventricular tachycardia (HP:0004756)1.88643406
112Osteolytic defects of the phalanges of the hand (HP:0009771)1.87351990
113Osteolytic defects of the hand bones (HP:0009699)1.87351990
114Deviation of the hallux (HP:0010051)1.86879565
115Supernumerary ribs (HP:0005815)1.86697752
116Postaxial hand polydactyly (HP:0001162)1.85743652
117Asymmetry of the thorax (HP:0001555)1.85561267
118Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.84264606
119Abnormality of the parietal bone (HP:0002696)1.83926625
120Distal arthrogryposis (HP:0005684)1.83655409
121Blue sclerae (HP:0000592)1.83147081
122Genu recurvatum (HP:0002816)1.82397192
123Hallux valgus (HP:0001822)1.82285431
124Wormian bones (HP:0002645)1.81918052
125Optic nerve hypoplasia (HP:0000609)1.81117676
126Bicuspid aortic valve (HP:0001647)1.80913958
127Aplasia/Hypoplasia of the hallux (HP:0008362)1.80905533
128Stenosis of the external auditory canal (HP:0000402)1.80810529
129Adactyly (HP:0009776)1.80328763
130Slender build (HP:0001533)1.80315610
131Hyperextensible skin (HP:0000974)1.80314825
132Short hallux (HP:0010109)1.80194972
133Left ventricular hypertrophy (HP:0001712)1.79540215
134Midline defect of the nose (HP:0004122)1.79402721
135Abnormality of the phalanges of the 2nd finger (HP:0009541)1.78927038
136Increased corneal curvature (HP:0100692)1.78895775
137Keratoconus (HP:0000563)1.78895775
138Poor coordination (HP:0002370)1.78492061
139Bronchomalacia (HP:0002780)1.77843570
140Abnormality of serine family amino acid metabolism (HP:0010894)1.77685678
141Abnormality of glycine metabolism (HP:0010895)1.77685678
142Lip pit (HP:0100267)1.76908501
143Striae distensae (HP:0001065)1.76765807
144Centrally nucleated skeletal muscle fibers (HP:0003687)1.76077559
145Venous abnormality (HP:0002624)1.75845690
146Sclerocornea (HP:0000647)1.75333982
147Broad hallux (HP:0010055)1.74914111
148Abnormality of the diencephalon (HP:0010662)1.74646882
149Difficulty climbing stairs (HP:0003551)1.72975858
150Aplasia/Hypoplasia of the spleen (HP:0010451)1.72587978
151Nonimmune hydrops fetalis (HP:0001790)1.72559291
152Morphological abnormality of the middle ear (HP:0008609)1.72298483
153Skull defect (HP:0001362)1.72145477
154Syringomyelia (HP:0003396)1.71818647
155Spinal cord lesions (HP:0100561)1.71818647
156Tarsal synostosis (HP:0008368)1.71737508
157Abnormality of abdominal situs (HP:0011620)1.70698970
158Abdominal situs inversus (HP:0003363)1.70698970
159Trismus (HP:0000211)1.70547768
160Limited hip movement (HP:0008800)1.70458942
161Germ cell neoplasia (HP:0100728)1.69963720
162Preaxial hand polydactyly (HP:0001177)1.69809553
163Arthropathy (HP:0003040)1.68798184
164Infantile muscular hypotonia (HP:0008947)1.68625578
165Abnormality of the nasal septum (HP:0000419)1.68307520
166Joint contractures involving the joints of the feet (HP:0100492)1.68052293
167Flexion contracture of toe (HP:0005830)1.68052293
168Trigonocephaly (HP:0000243)1.67539775
169Broad toe (HP:0001837)1.67416720
170Mitral regurgitation (HP:0001653)1.65747926
171Coarctation of aorta (HP:0001680)1.65548024
172Arnold-Chiari malformation (HP:0002308)1.65069984
173Basal cell carcinoma (HP:0002671)1.64749293
174Aplasia/Hypoplasia of the ulna (HP:0006495)1.64593127
175Broad palm (HP:0001169)1.64510367
176Narrow palate (HP:0000189)1.64150623
177Abnormality of the pubic bones (HP:0003172)1.63984599
178Poikiloderma (HP:0001029)1.63823986
179High anterior hairline (HP:0009890)1.63414104
180Broad long bones (HP:0005622)1.62884464
181Congenital stationary night blindness (HP:0007642)1.62513614
182Spontaneous hematomas (HP:0007420)1.62353740
183Joint laxity (HP:0001388)1.61998276
184Facial diplegia (HP:0001349)1.61358073

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.04407236
2RIPK12.94945409
3TAOK12.86007661
4TIE12.83611356
5TGFBR22.63254274
6MKNK12.44813557
7PNCK2.38209147
8WNK32.27956978
9MAP3K32.27131500
10TTN2.26746034
11KDR2.20613666
12MAP2K32.20185948
13TGFBR12.07085981
14PDGFRA2.06858284
15LATS12.04553945
16ZAP701.95311417
17TNIK1.93909431
18PINK11.90269357
19PKN21.88757300
20CHUK1.88073993
21EEF2K1.84917036
22BCKDK1.83452558
23OBSCN1.80918934
24DYRK21.77035766
25PTK61.76623428
26MAPK151.75122050
27WEE11.68352981
28JAK31.67059895
29BMPR1B1.63773653
30MAP3K111.62099848
31DMPK1.61970923
32NUAK11.60858659
33MAP4K11.60341140
34MAP3K101.58768288
35NTRK11.57425917
36LRRK21.53251966
37STK101.52535630
38MAP2K21.50009600
39PDGFRB1.49272204
40MAP4K21.46716329
41TAOK21.45879632
42MARK11.44011534
43EPHA41.43539992
44EPHB11.43169389
45RPS6KA41.42709750
46PIK3CA1.40567522
47DYRK1B1.39083219
48DYRK31.37524292
49SIK11.34998702
50PAK21.31157571
51FGFR41.29968437
52CDK191.29755541
53FGFR21.26945411
54CDK91.16553804
55NTRK21.15485768
56MTOR1.14879581
57PAK41.14030294
58STK391.12538451
59MAP3K71.10333771
60PIM21.09822071
61FER1.09443017
62ILK1.06528570
63ERN11.06315134
64CDK121.03719471
65BMX1.03560305
66MAPK71.03383060
67FGFR11.03102017
68MAP3K41.02669603
69EPHB21.00934812
70SRPK11.00480830
71GRK10.98524675
72DYRK1A0.97852915
73TSSK60.97587619
74LMTK20.95088896
75EPHA30.93262583
76IKBKB0.93099438
77MAP2K70.92096742
78DDR20.91768245
79CDK60.91246162
80BRSK20.88914477
81IKBKE0.86775246
82TYRO30.85975248
83LATS20.85879309
84MAP3K10.85695505
85PDK20.84395744
86STK240.84163028
87STK38L0.83364374
88TXK0.83275149
89CSK0.83117436
90FGFR30.82315707
91ADRBK20.81777032
92CAMK10.80197659
93MAP3K140.78700326
94GSK3A0.78448471
95EPHA20.78005335
96ERBB30.77756645
97MAPK130.77751723
98BCR0.77396166
99MAP3K80.77141813
100MOS0.77009657
101ROCK20.75870839
102RPS6KB20.74409846
103BRD40.73911538
104MST40.73712304
105NEK20.73267423
106VRK10.71203492
107STK30.70929853
108PTK20.70697995
109PRKD20.70604299
110ERBB20.68287760
111ITK0.67508000
112PRKCE0.67500761
113PHKG10.66712593
114PHKG20.66712593
115CLK10.66684363
116KIT0.64771268
117WNK40.64666284
118NLK0.64406449
119MUSK0.63706764
120TBK10.63617695
121INSRR0.63048094
122VRK20.62688279
123PRKD10.62509545
124NEK90.60518839
125PAK30.60040332
126SGK4940.56588917
127SGK2230.56588917
128MET0.54808574
129PRKCG0.53956889
130STK160.53354170
131RPS6KA10.53185639
132MYLK0.52741569
133MKNK20.52164623
134PKN10.51807515
135MAP3K20.51718757
136CDK80.51085012
137ADRBK10.50298074
138CSNK1G10.50185218
139PLK20.49494863
140MST1R0.49480472
141CDK40.49400745
142RPS6KA60.49347230
143ERBB40.48514759
144NEK10.48365712
145MAPKAPK20.48280641
146ALK0.47551222
147MAP3K50.47392854
148CDK30.47250611
149PRKACA0.46901871
150CASK0.46231170
151ABL20.45881831
152CDC70.44482680
153FLT30.44284962
154MATK0.44219624
155PRKG10.43370069
156CDK70.42691630
157CAMK40.41571921
158PIM10.41170967
159PRKCH0.40162178
160RPS6KL10.39527385
161RPS6KC10.39527385
162MARK20.39426034
163CAMK1G0.37481439
164INSR0.37138820
165MAPK10.36000437

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.43602895
2Small cell lung cancer_Homo sapiens_hsa052222.26263960
3Propanoate metabolism_Homo sapiens_hsa006402.20137958
4AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.17696343
5Sulfur relay system_Homo sapiens_hsa041222.04538266
6Focal adhesion_Homo sapiens_hsa045102.02524346
7Chronic myeloid leukemia_Homo sapiens_hsa052202.02424734
8Viral myocarditis_Homo sapiens_hsa054162.02278436
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.98851825
10Adherens junction_Homo sapiens_hsa045201.98117074
11Cardiac muscle contraction_Homo sapiens_hsa042601.96816881
12Basal cell carcinoma_Homo sapiens_hsa052171.95775611
13Ribosome_Homo sapiens_hsa030101.94429139
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.91153160
15Protein export_Homo sapiens_hsa030601.88073963
16T cell receptor signaling pathway_Homo sapiens_hsa046601.85307564
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.77873720
18MicroRNAs in cancer_Homo sapiens_hsa052061.76153156
19Hippo signaling pathway_Homo sapiens_hsa043901.75910183
20Allograft rejection_Homo sapiens_hsa053301.72046082
21Phototransduction_Homo sapiens_hsa047441.70708590
22TGF-beta signaling pathway_Homo sapiens_hsa043501.69212754
23Toxoplasmosis_Homo sapiens_hsa051451.67135364
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.65658933
25Proteoglycans in cancer_Homo sapiens_hsa052051.64791558
26Thyroid cancer_Homo sapiens_hsa052161.64530121
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.63029641
28HTLV-I infection_Homo sapiens_hsa051661.62930383
29Notch signaling pathway_Homo sapiens_hsa043301.58362913
30Linoleic acid metabolism_Homo sapiens_hsa005911.55468888
31TNF signaling pathway_Homo sapiens_hsa046681.54988688
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.54518489
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.50775703
34Bladder cancer_Homo sapiens_hsa052191.49460969
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.48756333
36Acute myeloid leukemia_Homo sapiens_hsa052211.46192587
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.46112308
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.44349984
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.43438291
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41958795
41Prolactin signaling pathway_Homo sapiens_hsa049171.41561003
42Nitrogen metabolism_Homo sapiens_hsa009101.40597021
43Dilated cardiomyopathy_Homo sapiens_hsa054141.40385504
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.38981110
45Parkinsons disease_Homo sapiens_hsa050121.37513413
46Fatty acid elongation_Homo sapiens_hsa000621.37220721
47Hedgehog signaling pathway_Homo sapiens_hsa043401.35634768
48Malaria_Homo sapiens_hsa051441.35475643
49Amoebiasis_Homo sapiens_hsa051461.34598960
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34311729
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.33680882
52Fatty acid degradation_Homo sapiens_hsa000711.33667372
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.31584112
54Steroid biosynthesis_Homo sapiens_hsa001001.30554243
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.29746721
56Phenylalanine metabolism_Homo sapiens_hsa003601.28609459
57Prostate cancer_Homo sapiens_hsa052151.28542786
58Asthma_Homo sapiens_hsa053101.27381064
59Pathways in cancer_Homo sapiens_hsa052001.27124454
60Pancreatic cancer_Homo sapiens_hsa052121.23744907
61Colorectal cancer_Homo sapiens_hsa052101.21233374
62Cyanoamino acid metabolism_Homo sapiens_hsa004601.20875288
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18680710
64Jak-STAT signaling pathway_Homo sapiens_hsa046301.17566095
65Oxidative phosphorylation_Homo sapiens_hsa001901.17495935
66Tight junction_Homo sapiens_hsa045301.17032011
67PI3K-Akt signaling pathway_Homo sapiens_hsa041511.15204480
68Leishmaniasis_Homo sapiens_hsa051401.13140062
69Osteoclast differentiation_Homo sapiens_hsa043801.13015313
70Fatty acid metabolism_Homo sapiens_hsa012121.12325850
71Huntingtons disease_Homo sapiens_hsa050161.11057292
72Autoimmune thyroid disease_Homo sapiens_hsa053201.09025008
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.08194991
74Protein digestion and absorption_Homo sapiens_hsa049741.08009788
75Hepatitis B_Homo sapiens_hsa051611.07879184
76Circadian rhythm_Homo sapiens_hsa047101.07084070
77Measles_Homo sapiens_hsa051621.06784289
78Tyrosine metabolism_Homo sapiens_hsa003501.05805021
79Tryptophan metabolism_Homo sapiens_hsa003801.05558684
80PPAR signaling pathway_Homo sapiens_hsa033201.02613384
81Butanoate metabolism_Homo sapiens_hsa006501.02108102
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00380276
83Renal cell carcinoma_Homo sapiens_hsa052111.00243351
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00023900
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99967565
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.99733548
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99212645
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.95301166
89Fat digestion and absorption_Homo sapiens_hsa049750.94202577
90Shigellosis_Homo sapiens_hsa051310.94167899
91Apoptosis_Homo sapiens_hsa042100.93991215
92Wnt signaling pathway_Homo sapiens_hsa043100.93754047
93Endometrial cancer_Homo sapiens_hsa052130.92485740
94Insulin resistance_Homo sapiens_hsa049310.92180045
95Rap1 signaling pathway_Homo sapiens_hsa040150.91999304
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.91848425
97p53 signaling pathway_Homo sapiens_hsa041150.91809794
98VEGF signaling pathway_Homo sapiens_hsa043700.91803169
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91314556
100Arachidonic acid metabolism_Homo sapiens_hsa005900.90914235
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90618834
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90577464
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89153191
104Graft-versus-host disease_Homo sapiens_hsa053320.87355807
105Alzheimers disease_Homo sapiens_hsa050100.86756797
106Platelet activation_Homo sapiens_hsa046110.86355295
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86171432
108beta-Alanine metabolism_Homo sapiens_hsa004100.85573446
109Histidine metabolism_Homo sapiens_hsa003400.84218761
110Viral carcinogenesis_Homo sapiens_hsa052030.84191943
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84154247
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.84025631
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83965341
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.83351883
115Ovarian steroidogenesis_Homo sapiens_hsa049130.82522056
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.81982414
117Fanconi anemia pathway_Homo sapiens_hsa034600.81434520
118Primary immunodeficiency_Homo sapiens_hsa053400.80069083
119MAPK signaling pathway_Homo sapiens_hsa040100.79919386
120RNA polymerase_Homo sapiens_hsa030200.79136218
121Herpes simplex infection_Homo sapiens_hsa051680.78180242
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.78091816
123Complement and coagulation cascades_Homo sapiens_hsa046100.75799521
124Arginine and proline metabolism_Homo sapiens_hsa003300.75525780
125Hepatitis C_Homo sapiens_hsa051600.74236186
126Melanoma_Homo sapiens_hsa052180.72971609
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70224739
128Lysine degradation_Homo sapiens_hsa003100.69980731
129RNA degradation_Homo sapiens_hsa030180.69692270
130Legionellosis_Homo sapiens_hsa051340.69521602
131Circadian entrainment_Homo sapiens_hsa047130.69337211
132Retinol metabolism_Homo sapiens_hsa008300.67935176
133Glycerolipid metabolism_Homo sapiens_hsa005610.67875722
134Peroxisome_Homo sapiens_hsa041460.67598497
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65279507
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64789395
1372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64425158
138B cell receptor signaling pathway_Homo sapiens_hsa046620.63714000
139Influenza A_Homo sapiens_hsa051640.63600428
140Estrogen signaling pathway_Homo sapiens_hsa049150.63113644
141Chemical carcinogenesis_Homo sapiens_hsa052040.62124090
142FoxO signaling pathway_Homo sapiens_hsa040680.61974091
143Glioma_Homo sapiens_hsa052140.61966466
144Dorso-ventral axis formation_Homo sapiens_hsa043200.60531752
145Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.60500476
146Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60426598
147Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59912576
148HIF-1 signaling pathway_Homo sapiens_hsa040660.59878069
149Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59501271
150Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59072413
151Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58991724
152ABC transporters_Homo sapiens_hsa020100.58779493
153Antigen processing and presentation_Homo sapiens_hsa046120.58133929
154Axon guidance_Homo sapiens_hsa043600.57552822
155Vitamin digestion and absorption_Homo sapiens_hsa049770.57288540
156Ether lipid metabolism_Homo sapiens_hsa005650.57273906
157Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55960758
158Non-small cell lung cancer_Homo sapiens_hsa052230.55423011
159Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54984675
160Ras signaling pathway_Homo sapiens_hsa040140.54448553
161Pyruvate metabolism_Homo sapiens_hsa006200.54433881
162Melanogenesis_Homo sapiens_hsa049160.54366895
163Salmonella infection_Homo sapiens_hsa051320.53614499
164Pertussis_Homo sapiens_hsa051330.52965638
165Morphine addiction_Homo sapiens_hsa050320.52880187
166Steroid hormone biosynthesis_Homo sapiens_hsa001400.51854331
167Thyroid hormone synthesis_Homo sapiens_hsa049180.51819823
168Renin secretion_Homo sapiens_hsa049240.50765883
169cAMP signaling pathway_Homo sapiens_hsa040240.48889301
170Hematopoietic cell lineage_Homo sapiens_hsa046400.48883563
171Taste transduction_Homo sapiens_hsa047420.48855831
172ErbB signaling pathway_Homo sapiens_hsa040120.48294022
173Cysteine and methionine metabolism_Homo sapiens_hsa002700.46647547
174Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45793875
175Calcium signaling pathway_Homo sapiens_hsa040200.44972712

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