SPRY2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein prenylation (GO:0018342)6.80809607
2prenylation (GO:0097354)6.80809607
3positive regulation of mitotic sister chromatid separation (GO:1901970)6.35054814
4positive regulation of mitotic metaphase/anaphase transition (GO:0045842)6.35054814
5positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)6.35054814
6presynaptic membrane assembly (GO:0097105)6.00155254
7postsynaptic membrane organization (GO:0001941)5.87076142
8regulation of sister chromatid cohesion (GO:0007063)5.76847591
9short-term memory (GO:0007614)5.75162940
10eosinophil chemotaxis (GO:0048245)5.55202307
11regulation of mononuclear cell migration (GO:0071675)5.35163752
12negative regulation of T cell receptor signaling pathway (GO:0050860)5.08788354
13presynaptic membrane organization (GO:0097090)5.06304087
14eosinophil migration (GO:0072677)5.06227594
15peptidyl-lysine dimethylation (GO:0018027)4.30921796
16positive regulation of chromosome segregation (GO:0051984)4.29960083
17localization within membrane (GO:0051668)4.19245243
18coenzyme A biosynthetic process (GO:0015937)4.07843445
19limb bud formation (GO:0060174)3.92172879
20regulation of timing of cell differentiation (GO:0048505)3.86013895
21positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.79565199
22neuronal action potential propagation (GO:0019227)3.74790269
23retina layer formation (GO:0010842)3.71042297
24fucose catabolic process (GO:0019317)3.69157251
25L-fucose metabolic process (GO:0042354)3.69157251
26L-fucose catabolic process (GO:0042355)3.69157251
27GMP metabolic process (GO:0046037)3.68157391
28neuron cell-cell adhesion (GO:0007158)3.65217830
29vesicle fusion (GO:0006906)3.61963653
30regulation of development, heterochronic (GO:0040034)3.51500731
31neuron projection extension involved in neuron projection guidance (GO:1902284)3.51257977
32axon extension involved in axon guidance (GO:0048846)3.51257977
33protein heterotetramerization (GO:0051290)3.48944967
34regulation of mammary gland epithelial cell proliferation (GO:0033599)3.43980905
35metanephric mesenchyme development (GO:0072075)3.41993295
36macrophage chemotaxis (GO:0048246)3.38887875
37spermatid nucleus differentiation (GO:0007289)3.35029094
38negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.34937058
39protein localization to synapse (GO:0035418)3.33897102
40axon ensheathment in central nervous system (GO:0032291)3.33505971
41central nervous system myelination (GO:0022010)3.33505971
42ribosomal small subunit assembly (GO:0000028)3.30928738
43regulation of stem cell maintenance (GO:2000036)3.30791919
44kidney mesenchyme development (GO:0072074)3.29153027
45cerebral cortex radially oriented cell migration (GO:0021799)3.22070160
46negative regulation of synaptic transmission, GABAergic (GO:0032229)3.21631942
47notochord development (GO:0030903)3.21122553
48positive regulation of protein kinase C signaling (GO:0090037)3.19713223
49planar cell polarity pathway involved in neural tube closure (GO:0090179)3.13982986
50endothelium development (GO:0003158)3.13678597
51G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.12737346
52mesenchymal cell differentiation involved in renal system development (GO:2001012)3.10837807
53mesenchymal cell differentiation involved in kidney development (GO:0072161)3.10837807
54negative regulation of keratinocyte proliferation (GO:0010839)3.09372966
55positive regulation of synapse assembly (GO:0051965)3.07800842
56cell differentiation involved in metanephros development (GO:0072202)3.07376270
57chondrocyte proliferation (GO:0035988)3.06116712
58startle response (GO:0001964)3.05707843
59organ induction (GO:0001759)3.05643267
60negative regulation of catenin import into nucleus (GO:0035414)3.03449612
61muscle cell fate commitment (GO:0042693)3.02184786
62cranial nerve structural organization (GO:0021604)3.01762914
63cranial nerve morphogenesis (GO:0021602)3.01372981
64facial nerve structural organization (GO:0021612)3.00492823
65nonmotile primary cilium assembly (GO:0035058)2.99506689
66dermatan sulfate biosynthetic process (GO:0030208)2.98654289
67positive regulation of calcium ion import (GO:0090280)2.97607650
68regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.97045322
69ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.96797951
70nucleoside bisphosphate biosynthetic process (GO:0033866)2.96797951
71purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.96797951
72lateral sprouting from an epithelium (GO:0060601)2.96544707
73regulation of pigment cell differentiation (GO:0050932)2.96027822
74positive chemotaxis (GO:0050918)2.95187984
75protein import into peroxisome matrix (GO:0016558)2.92463999
76regulation of beta-amyloid formation (GO:1902003)2.88669941
77positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.87416280
78regulation of male gonad development (GO:2000018)2.85531672
79righting reflex (GO:0060013)2.84394750
803-UTR-mediated mRNA stabilization (GO:0070935)2.84280071
81negative regulation of circadian rhythm (GO:0042754)2.81534471
82vocalization behavior (GO:0071625)2.81352476
83sympathetic nervous system development (GO:0048485)2.81176664
84otic vesicle formation (GO:0030916)2.81133440
85regulation of synapse assembly (GO:0051963)2.80955696
86dermatan sulfate metabolic process (GO:0030205)2.80200236
87proximal/distal pattern formation (GO:0009954)2.79475541
88regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.79315975
89transmission of nerve impulse (GO:0019226)2.79276526
90double-strand break repair via nonhomologous end joining (GO:0006303)2.78590250
91non-recombinational repair (GO:0000726)2.78590250
92photoreceptor cell differentiation (GO:0046530)2.74390794
93eye photoreceptor cell differentiation (GO:0001754)2.74390794
94regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.73891124
95negative regulation of execution phase of apoptosis (GO:1900118)2.73865172
96regulation of inositol phosphate biosynthetic process (GO:0010919)2.72933049
97paraxial mesoderm development (GO:0048339)2.72843324
98omega-hydroxylase P450 pathway (GO:0097267)2.71622265
99cell-cell signaling involved in cell fate commitment (GO:0045168)2.71412220
100acrosome assembly (GO:0001675)2.71138519
101developmental induction (GO:0031128)2.69616426
102ionotropic glutamate receptor signaling pathway (GO:0035235)2.69344461
103epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.66572633
104glutamate receptor signaling pathway (GO:0007215)2.65742664
105negative regulation of chondrocyte differentiation (GO:0032331)2.63814106
106endocardial cushion morphogenesis (GO:0003203)2.62705924
107photoreceptor cell maintenance (GO:0045494)2.62080293
108cartilage condensation (GO:0001502)2.60126588
109cell aggregation (GO:0098743)2.60126588
110positive regulation of catenin import into nucleus (GO:0035413)2.59683530
111positive regulation of meiosis (GO:0045836)2.59596966
112GTP biosynthetic process (GO:0006183)2.59480316
113mesonephros development (GO:0001823)2.59262130
114axon extension (GO:0048675)2.58347431
115regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.57400726
116* negative regulation of Ras GTPase activity (GO:0034261)2.57211608
117oligodendrocyte differentiation (GO:0048709)2.56701503
118melanin metabolic process (GO:0006582)2.56569798
119Golgi transport vesicle coating (GO:0048200)2.56475383
120COPI coating of Golgi vesicle (GO:0048205)2.56475383
121retinal cone cell development (GO:0046549)2.55801755
122gamma-aminobutyric acid signaling pathway (GO:0007214)2.55486056
123regulation of catenin import into nucleus (GO:0035412)2.55264095
124outer ear morphogenesis (GO:0042473)2.54006461
125keratinocyte development (GO:0003334)2.53181684
126cilium movement (GO:0003341)2.52878006
127membrane assembly (GO:0071709)2.52370489
128glomerulus development (GO:0032835)2.52230891
129limb development (GO:0060173)2.52188252
130appendage development (GO:0048736)2.52188252
131regulation of protein kinase A signaling (GO:0010738)2.52117391
132cell differentiation involved in kidney development (GO:0061005)2.51026007
133cochlea morphogenesis (GO:0090103)2.49945018
134retinal rod cell development (GO:0046548)2.49819069
135positive regulation of astrocyte differentiation (GO:0048711)2.48726246
136cornea development in camera-type eye (GO:0061303)2.48666707
137eyelid development in camera-type eye (GO:0061029)2.48112710
138regulation of rhodopsin mediated signaling pathway (GO:0022400)2.47746868
139membrane budding (GO:0006900)2.47150228
140anatomical structure arrangement (GO:0048532)2.45844973
141neural crest cell development (GO:0014032)2.45376811
142regulation of heart morphogenesis (GO:2000826)2.45080208
143generation of neurons (GO:0048699)2.44849860
144negative regulation of myoblast differentiation (GO:0045662)2.44741195
145forebrain neuron development (GO:0021884)2.43448250
146regulation of cell fate specification (GO:0042659)2.43333200
147positive regulation of meiotic cell cycle (GO:0051446)2.43150152
148negative regulation of dendrite morphogenesis (GO:0050774)2.42601060
149mesenchyme morphogenesis (GO:0072132)2.42189462
150amino acid import (GO:0043090)2.42071676
151G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.41698411
152mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.40579705
153peripheral nervous system neuron development (GO:0048935)2.40566235
154monocyte chemotaxis (GO:0002548)2.39246368
155regulation of respiratory system process (GO:0044065)2.38666313
156positive regulation of male gonad development (GO:2000020)2.38328938
157regulation of calcium ion import (GO:0090279)2.38062642
158lens fiber cell development (GO:0070307)2.37846357
159fucose metabolic process (GO:0006004)2.37202987
160positive regulation of steroid hormone secretion (GO:2000833)2.36544217
161forebrain neuron differentiation (GO:0021879)2.35890913
162nephron epithelium development (GO:0072009)2.35607561
163epithelial cilium movement (GO:0003351)2.35447116
164synaptic transmission, glutamatergic (GO:0035249)2.35410626
165regulation of amyloid precursor protein catabolic process (GO:1902991)2.35004310
166reflex (GO:0060004)2.34130071
167cell migration involved in sprouting angiogenesis (GO:0002042)2.34117365
168negative regulation of neurotransmitter transport (GO:0051589)2.34003941
169mechanosensory behavior (GO:0007638)2.33593013
170regulation of mesenchymal cell apoptotic process (GO:2001053)2.32619733
171seminiferous tubule development (GO:0072520)2.32355508
172convergent extension (GO:0060026)2.32208812
173melanin biosynthetic process (GO:0042438)2.32103398
174L-amino acid import (GO:0043092)2.30835858
175dendrite development (GO:0016358)2.30670418
176regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.30336481
177mesenchymal cell development (GO:0014031)2.29998615
178astrocyte development (GO:0014002)2.29437515
179response to gravity (GO:0009629)2.28844233
180regulation of gastrulation (GO:0010470)2.28248213
181axonal fasciculation (GO:0007413)2.28078486
182positive regulation of fibroblast proliferation (GO:0048146)2.26697279
183positive regulation of cartilage development (GO:0061036)2.26597157
184coenzyme A metabolic process (GO:0015936)2.26421965
185Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.25923201
186myoblast migration (GO:0051451)2.25736604
187regulation of cardioblast differentiation (GO:0051890)2.24762110
188regulation of morphogenesis of a branching structure (GO:0060688)2.24488168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human4.84150803
2EZH2_22144423_ChIP-Seq_EOC_Human4.72544183
3GBX2_23144817_ChIP-Seq_PC3_Human3.56319130
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.14924750
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.12847466
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.92405249
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.89266957
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.78843002
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.71734152
10NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.65112970
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.62801284
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.58967934
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56586037
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.53988435
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51741730
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50052963
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50052963
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.44073315
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41236811
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.36708563
21POU5F1_16153702_ChIP-ChIP_HESCs_Human2.34011359
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33339631
23* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.32736535
24* AR_21572438_ChIP-Seq_LNCaP_Human2.28556025
25PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.26041243
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.22325334
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.17282717
28* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14239938
29RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.11326390
30* TAF15_26573619_Chip-Seq_HEK293_Human2.10976715
31CLOCK_20551151_ChIP-Seq_293T_Human2.10285366
32KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.05151889
33KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.05151889
34KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.05151889
35* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.98234564
36* RNF2_27304074_Chip-Seq_NSC_Mouse1.98221160
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.96406055
38EP300_21415370_ChIP-Seq_HL-1_Mouse1.96211182
39VDR_22108803_ChIP-Seq_LS180_Human1.91078646
40SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.88984681
41* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.88618774
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88006116
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87564262
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.85446005
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.83149084
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82064710
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.81868082
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79781716
49ZNF263_19887448_ChIP-Seq_K562_Human1.77226137
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74985160
51TP53_16413492_ChIP-PET_HCT116_Human1.74929333
52* P300_19829295_ChIP-Seq_ESCs_Human1.74338369
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74183227
54WT1_19549856_ChIP-ChIP_CCG9911_Human1.71546623
55* FUS_26573619_Chip-Seq_HEK293_Human1.71098361
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66196920
57MTF2_20144788_ChIP-Seq_MESCs_Mouse1.65907417
58* PIAS1_25552417_ChIP-Seq_VCAP_Human1.61223140
59* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.59441124
60SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.57946483
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.57886017
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54720404
63TRIM28_21343339_ChIP-Seq_HEK293_Human1.54529375
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53024310
65* SMAD3_21741376_ChIP-Seq_EPCs_Human1.49087030
66MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47015755
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.43634568
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42329072
69TBX3_20139965_ChIP-Seq_MESCs_Mouse1.41869368
70TBX3_20139965_ChIP-Seq_ESCs_Mouse1.41669981
71* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40607543
72TP63_17297297_ChIP-ChIP_HaCaT_Human1.40460481
73P53_22127205_ChIP-Seq_FIBROBLAST_Human1.39960560
74* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.39859228
75* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39487556
76ER_23166858_ChIP-Seq_MCF-7_Human1.39035245
77RING1B_27294783_Chip-Seq_NPCs_Mouse1.38759672
78SMAD4_21799915_ChIP-Seq_A2780_Human1.38427667
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36418405
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.36361588
81RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36245607
82* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35791134
83TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.32402758
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32195680
85SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32174629
86ISL1_27105846_Chip-Seq_CPCs_Mouse1.31722695
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30774291
88TP53_18474530_ChIP-ChIP_U2OS_Human1.29321050
89E2F1_18555785_Chip-Seq_ESCs_Mouse1.29210725
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27902836
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.27533393
92IGF1R_20145208_ChIP-Seq_DFB_Human1.26886937
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26368907
94RING1B_27294783_Chip-Seq_ESCs_Mouse1.22330444
95HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.22038779
96* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20575853
97P300_18555785_Chip-Seq_ESCs_Mouse1.20166221
98P53_22387025_ChIP-Seq_ESCs_Mouse1.19327313
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18842620
100* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.18119007
101* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17625936
102CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17075299
103EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16657104
104* RXR_22108803_ChIP-Seq_LS180_Human1.16502364
105PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15926577
106EWS_26573619_Chip-Seq_HEK293_Human1.15463646
107* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14219900
108CJUN_26792858_Chip-Seq_BT549_Human1.13969624
109* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13399340
110CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13231630
111SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12800024
112CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12722118
113ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10825424
114IRF1_19129219_ChIP-ChIP_H3396_Human1.10774837
115* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.10026601
116* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09672987
117NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09183213
118NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09183213
119ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08596669
120SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07450819
121EZH2_27294783_Chip-Seq_NPCs_Mouse1.07312736
122* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.07087123
123CMYC_18555785_Chip-Seq_ESCs_Mouse1.06806254
124TP63_19390658_ChIP-ChIP_HaCaT_Human1.05946169
125AR_25329375_ChIP-Seq_VCAP_Human1.04321929
126NMYC_18555785_Chip-Seq_ESCs_Mouse1.04215446
127STAT3_18555785_Chip-Seq_ESCs_Mouse1.03296572
128SOX2_16153702_ChIP-ChIP_HESCs_Human1.03070605
129TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02506195
130POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02506195
131SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02226528
132* RUNX2_22187159_ChIP-Seq_PCA_Human1.01935019
133* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01185909
134SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.00966355
135SOX2_18555785_Chip-Seq_ESCs_Mouse1.00678069
136JUN_21703547_ChIP-Seq_K562_Human1.00518963
137MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99302368
138MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98832339
139REST_21632747_ChIP-Seq_MESCs_Mouse0.98488612
140* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.98461151
141RUNX1_27457419_Chip-Seq_LIVER_Mouse0.98162248
142BCAT_22108803_ChIP-Seq_LS180_Human0.97697131
143SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97615624
144FOXM1_23109430_ChIP-Seq_U2OS_Human0.97488128
145* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97327888
146* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.95983174
147* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95936060
148* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.95102045
149OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94430671
150NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93944150
151* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93195559
152* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92651975
153RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90955626
154SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90341314
155GATA1_26923725_Chip-Seq_HPCs_Mouse0.89496080
156NANOG_16153702_ChIP-ChIP_HESCs_Human0.86748740
157* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.86634318

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.31553090
2MP0001188_hyperpigmentation3.91237123
3MP0003303_peritoneal_inflammation3.19258126
4MP0005409_darkened_coat_color3.13998263
5MP0006292_abnormal_olfactory_placode2.93758550
6MP0003880_abnormal_central_pattern2.89281956
7MP0008438_abnormal_cutaneous_collagen2.77077147
8MP0000566_synostosis2.52577033
9MP0009379_abnormal_foot_pigmentation2.46005149
10MP0000049_abnormal_middle_ear2.43062860
11MP0004272_abnormal_basement_membrane2.40225120
12MP0002249_abnormal_larynx_morphology2.24535160
13MP0005503_abnormal_tendon_morphology2.21021202
14MP0009250_abnormal_appendicular_skeleto2.07864501
15MP0005171_absent_coat_pigmentation2.05836480
16MP0002102_abnormal_ear_morphology2.04706148
17MP0009053_abnormal_anal_canal2.00731415
18MP0004381_abnormal_hair_follicle1.93514660
19MP0005508_abnormal_skeleton_morphology1.91188033
20MP0004270_analgesia1.83184241
21MP0003938_abnormal_ear_development1.79280580
22MP0001299_abnormal_eye_distance/1.79257204
23MP0001486_abnormal_startle_reflex1.71385242
24MP0000751_myopathy1.70062102
25MP0005623_abnormal_meninges_morphology1.66014450
26MP0010368_abnormal_lymphatic_system1.65279268
27MP0003937_abnormal_limbs/digits/tail_de1.64723858
28MP0003315_abnormal_perineum_morphology1.62630798
29MP0000778_abnormal_nervous_system1.60942672
30MP0000015_abnormal_ear_pigmentation1.59733076
31MP0009046_muscle_twitch1.57613581
32MP0001485_abnormal_pinna_reflex1.57572415
33* MP0000026_abnormal_inner_ear1.56515281
34MP0001968_abnormal_touch/_nociception1.50658652
35MP0002697_abnormal_eye_size1.49848092
36MP0000762_abnormal_tongue_morphology1.49183543
37MP0000631_abnormal_neuroendocrine_gland1.49119467
38MP0009745_abnormal_behavioral_response1.48712167
39MP0003755_abnormal_palate_morphology1.46855855
40MP0001293_anophthalmia1.46264452
41MP0002177_abnormal_outer_ear1.45768222
42MP0003635_abnormal_synaptic_transmissio1.44626361
43MP0005197_abnormal_uvea_morphology1.44349554
44MP0002272_abnormal_nervous_system1.44070412
45* MP0003115_abnormal_respiratory_system1.42231055
46MP0008260_abnormal_autophagy1.41280860
47MP0005275_abnormal_skin_tensile1.41019888
48MP0008789_abnormal_olfactory_epithelium1.40422773
49MP0000733_abnormal_muscle_development1.39032215
50MP0003329_amyloid_beta_deposits1.38945554
51MP0003385_abnormal_body_wall1.37238646
52MP0005646_abnormal_pituitary_gland1.36950898
53MP0005248_abnormal_Harderian_gland1.36429830
54MP0000579_abnormal_nail_morphology1.36078547
55MP0003705_abnormal_hypodermis_morpholog1.34557969
56MP0004742_abnormal_vestibular_system1.33963315
57MP0004142_abnormal_muscle_tone1.33898760
58MP0004859_abnormal_synaptic_plasticity1.30503681
59MP0004145_abnormal_muscle_electrophysio1.30233193
60MP0002067_abnormal_sensory_capabilities1.29649030
61MP0009384_cardiac_valve_regurgitation1.27817545
62MP0001915_intracranial_hemorrhage1.26995744
63MP0002572_abnormal_emotion/affect_behav1.25743779
64MP0000749_muscle_degeneration1.25153958
65MP0000383_abnormal_hair_follicle1.24795298
66MP0002064_seizures1.24447239
67MP0005645_abnormal_hypothalamus_physiol1.23393311
68MP0004885_abnormal_endolymph1.22885675
69MP0002734_abnormal_mechanical_nocicepti1.22421607
70* MP0001963_abnormal_hearing_physiology1.21908211
71MP0002233_abnormal_nose_morphology1.21242878
72MP0001986_abnormal_taste_sensitivity1.21099514
73MP0002932_abnormal_joint_morphology1.20576898
74MP0005499_abnormal_olfactory_system1.19948752
75MP0005394_taste/olfaction_phenotype1.19948752
76MP0006082_CNS_inflammation1.17525751
77MP0002735_abnormal_chemical_nociception1.16981216
78MP0002638_abnormal_pupillary_reflex1.15675472
79MP0002557_abnormal_social/conspecific_i1.15674294
80MP0005551_abnormal_eye_electrophysiolog1.15084442
81* MP0000428_abnormal_craniofacial_morphol1.14387674
82MP0002009_preneoplasia1.13825016
83* MP0002752_abnormal_somatic_nervous1.13444875
84MP0002653_abnormal_ependyma_morphology1.12705667
85MP0002116_abnormal_craniofacial_bone1.11760988
86MP0002282_abnormal_trachea_morphology1.11324038
87MP0001177_atelectasis1.11017898
88MP0003950_abnormal_plasma_membrane1.10831207
89MP0003283_abnormal_digestive_organ1.10707768
90MP0002063_abnormal_learning/memory/cond1.10688258
91MP0003718_maternal_effect1.10566207
92MP0010030_abnormal_orbit_morphology1.10181580
93MP0003091_abnormal_cell_migration1.09163340
94MP0006072_abnormal_retinal_apoptosis1.08722739
95MP0003941_abnormal_skin_development1.08631585
96MP0002896_abnormal_bone_mineralization1.06026995
97MP0003942_abnormal_urinary_system1.05493333
98MP0001958_emphysema1.04557426
99* MP0002109_abnormal_limb_morphology1.02806844
100MP0002876_abnormal_thyroid_physiology1.02437284
101MP0002736_abnormal_nociception_after1.01338858
102MP0002115_abnormal_skeleton_extremities0.99991259
103MP0002184_abnormal_innervation0.99550030
104MP0001879_abnormal_lymphatic_vessel0.98153894
105MP0000759_abnormal_skeletal_muscle0.95005717
106MP0000955_abnormal_spinal_cord0.94690694
107* MP0001286_abnormal_eye_development0.94632122
108* MP0000432_abnormal_head_morphology0.94541563
109MP0005257_abnormal_intraocular_pressure0.94404553
110MP0004133_heterotaxia0.93847461
111MP0002277_abnormal_respiratory_mucosa0.93597908
112MP0004858_abnormal_nervous_system0.93579200
113* MP0002882_abnormal_neuron_morphology0.93565613
114MP0002938_white_spotting0.93027470
115MP0001440_abnormal_grooming_behavior0.92931591
116MP0003878_abnormal_ear_physiology0.92881857
117MP0005377_hearing/vestibular/ear_phenot0.92881857
118MP0001970_abnormal_pain_threshold0.92501048
119MP0000537_abnormal_urethra_morphology0.91520846
120MP0008995_early_reproductive_senescence0.91349162
121MP0002092_abnormal_eye_morphology0.91291003
122MP0001919_abnormal_reproductive_system0.91153910
123MP0002160_abnormal_reproductive_system0.90315302
124MP0006276_abnormal_autonomic_nervous0.90110690
125MP0005187_abnormal_penis_morphology0.87887878
126MP0000163_abnormal_cartilage_morphology0.87500816
127MP0001905_abnormal_dopamine_level0.86288833
128MP0009672_abnormal_birth_weight0.86161565
129MP0010678_abnormal_skin_adnexa0.85541248
130MP0002234_abnormal_pharynx_morphology0.85303083
131MP0002114_abnormal_axial_skeleton0.85203961
132MP0005367_renal/urinary_system_phenotyp0.84412057
133MP0000516_abnormal_urinary_system0.84412057
134* MP0002751_abnormal_autonomic_nervous0.83853578
135MP0001501_abnormal_sleep_pattern0.83786749
136MP0004087_abnormal_muscle_fiber0.83096349
137MP0002113_abnormal_skeleton_development0.83023681
138MP0003453_abnormal_keratinocyte_physiol0.82351572
139MP0002111_abnormal_tail_morphology0.82292448
140MP0002108_abnormal_muscle_morphology0.82139983
141MP0005253_abnormal_eye_physiology0.81581207
142MP0008569_lethality_at_weaning0.80669943
143MP0001346_abnormal_lacrimal_gland0.80256076
144MP0003634_abnormal_glial_cell0.80170054
145* MP0003935_abnormal_craniofacial_develop0.79655479
146MP0001340_abnormal_eyelid_morphology0.79486399
147MP0004084_abnormal_cardiac_muscle0.78699443
148MP0000534_abnormal_ureter_morphology0.78611396
149MP0003279_aneurysm0.78256156
150MP0005595_abnormal_vascular_smooth0.78021520
151MP0005076_abnormal_cell_differentiation0.76908023
152MP0003119_abnormal_digestive_system0.76299051
153MP0005023_abnormal_wound_healing0.75856757
154MP0005391_vision/eye_phenotype0.75595986
155MP0005193_abnormal_anterior_eye0.74433635
156MP0001502_abnormal_circadian_rhythm0.74426691
157MP0005423_abnormal_somatic_nervous0.72891168
158MP0002085_abnormal_embryonic_tissue0.72102768
159MP0003566_abnormal_cell_adhesion0.71334460
160* MP0002081_perinatal_lethality0.71319262
161* MP0003861_abnormal_nervous_system0.71013791
162MP0000462_abnormal_digestive_system0.68874453
163MP0006138_congestive_heart_failure0.65192778

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of long-chain fatty-acid metabolism (HP:0010964)5.32461802
2Hypoplastic pelvis (HP:0008839)4.24345525
3Abnormal sex determination (HP:0012244)3.93765951
4Sex reversal (HP:0012245)3.93765951
5Adactyly (HP:0009776)3.70248326
6Long foot (HP:0001833)3.61161349
7Premature rupture of membranes (HP:0001788)3.56866508
8Septo-optic dysplasia (HP:0100842)3.52883561
9Focal motor seizures (HP:0011153)3.32205602
10Abnormality of secondary sexual hair (HP:0009888)3.28077848
11Abnormality of the axillary hair (HP:0100134)3.28077848
12Duplicated collecting system (HP:0000081)3.25943441
13Split foot (HP:0001839)3.23632498
14Abnormal auditory evoked potentials (HP:0006958)3.17029941
15Neonatal short-limb short stature (HP:0008921)3.09013295
16Large for gestational age (HP:0001520)3.00262305
17Abnormal ciliary motility (HP:0012262)2.99130600
18Optic nerve hypoplasia (HP:0000609)2.94034302
19Dynein arm defect of respiratory motile cilia (HP:0012255)2.91770059
20Absent/shortened dynein arms (HP:0200106)2.91770059
21Aplasia involving bones of the upper limbs (HP:0009823)2.89839938
22Aplasia of the phalanges of the hand (HP:0009802)2.89839938
23Aplasia involving bones of the extremities (HP:0009825)2.89839938
24Progressive muscle weakness (HP:0003323)2.87043804
25Nonprogressive disorder (HP:0003680)2.79093169
26Abnormality of the septum pellucidum (HP:0007375)2.78813358
27Abnormal ventriculo-arterial connection (HP:0011563)2.69922429
28Transposition of the great arteries (HP:0001669)2.69922429
29Abnormal connection of the cardiac segments (HP:0011545)2.69922429
30Abnormality of the renal collecting system (HP:0004742)2.69553210
31Protrusio acetabuli (HP:0003179)2.69353931
32Sudden death (HP:0001699)2.69201066
33Nasolacrimal duct obstruction (HP:0000579)2.67983703
34Abnormality of the phalanges of the 2nd finger (HP:0009541)2.65275092
35Absent septum pellucidum (HP:0001331)2.64052322
36Generalized amyotrophy (HP:0003700)2.59896750
37Hammertoe (HP:0001765)2.55705218
38Hypoplastic nipples (HP:0002557)2.55383208
39Abnormal respiratory motile cilium morphology (HP:0005938)2.54629009
40Abnormal respiratory epithelium morphology (HP:0012253)2.54629009
41Calcaneovalgus deformity (HP:0001848)2.54608516
42Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.53828555
43Shallow orbits (HP:0000586)2.49750951
44True hermaphroditism (HP:0010459)2.48388143
45Supernumerary spleens (HP:0009799)2.47867715
46Myoglobinuria (HP:0002913)2.47822387
47Concave nail (HP:0001598)2.47725084
48Febrile seizures (HP:0002373)2.47663313
49Arterial tortuosity (HP:0005116)2.45446331
50Abnormal respiratory motile cilium physiology (HP:0012261)2.45396542
51Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.45389679
52Abnormality of incisor morphology (HP:0011063)2.41398391
53Obstructive sleep apnea (HP:0002870)2.41279487
54Reduced subcutaneous adipose tissue (HP:0003758)2.40826145
55Tracheomalacia (HP:0002779)2.40751559
56Mixed hearing impairment (HP:0000410)2.38760743
57Abnormality of the lacrimal duct (HP:0011481)2.36581754
58Vascular tortuosity (HP:0004948)2.36493213
59Attenuation of retinal blood vessels (HP:0007843)2.30703876
60Aortic dissection (HP:0002647)2.30214917
61Abnormality of the nasolacrimal system (HP:0000614)2.29386929
62Fibular aplasia (HP:0002990)2.29225131
63Abnormality of dentin (HP:0010299)2.27471525
64Menstrual irregularities (HP:0000858)2.26773073
65Aplasia cutis congenita (HP:0001057)2.25172731
66Dry hair (HP:0011359)2.25075963
67Type 1 muscle fiber predominance (HP:0003803)2.23351023
68Deformed tarsal bones (HP:0008119)2.23111727
69Hypoplastic left heart (HP:0004383)2.22707601
70Acute lymphatic leukemia (HP:0006721)2.22041989
71Autoamputation (HP:0001218)2.19894725
72Abnormality of the nasal septum (HP:0000419)2.18141012
73Increased number of teeth (HP:0011069)2.16807897
74Alacrima (HP:0000522)2.16041391
75Epileptic encephalopathy (HP:0200134)2.15943889
76Broad-based gait (HP:0002136)2.14682558
77Coronal craniosynostosis (HP:0004440)2.14127640
78Synostosis involving the elbow (HP:0003938)2.13500355
79Humeroradial synostosis (HP:0003041)2.13500355
80Nephronophthisis (HP:0000090)2.12925621
81Abnormality of fatty-acid metabolism (HP:0004359)2.11924179
82Aplasia/hypoplasia of the uterus (HP:0008684)2.11207383
83Sleep apnea (HP:0010535)2.10511490
84Chin dimple (HP:0010751)2.08725126
85Short tibia (HP:0005736)2.08160663
86Steppage gait (HP:0003376)2.07979249
87Long nose (HP:0003189)2.07630530
88Atonic seizures (HP:0010819)2.05466909
89Spinal rigidity (HP:0003306)2.04977780
90Decreased muscle mass (HP:0003199)2.04678946
91Absent toe (HP:0010760)2.04263031
92Medial flaring of the eyebrow (HP:0010747)2.03299813
93Aplasia/Hypoplasia of the breasts (HP:0010311)2.02198850
94Abnormality of the renal medulla (HP:0100957)2.00750445
95Submucous cleft hard palate (HP:0000176)2.00272270
96Morphological abnormality of the middle ear (HP:0008609)2.00124391
97Hypoplastic heart (HP:0001961)1.99455266
98Aplasia/Hypoplasia of the tibia (HP:0005772)1.97974920
99Breast aplasia (HP:0100783)1.96907261
100Thyroid-stimulating hormone excess (HP:0002925)1.96595656
101Aplasia/Hypoplasia of the fibula (HP:0006492)1.96530430
102Broad nasal tip (HP:0000455)1.96315670
103Follicular hyperkeratosis (HP:0007502)1.95489007
104Abnormality of the phalanges of the 5th finger (HP:0004213)1.94630221
105Abnormality of the 4th metacarpal (HP:0010012)1.94085967
106Ureteral duplication (HP:0000073)1.93999556
107Fibular hypoplasia (HP:0003038)1.93005507
108White forelock (HP:0002211)1.92781989
109Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.91853474
110Pancreatic fibrosis (HP:0100732)1.91226828
111Bladder diverticulum (HP:0000015)1.90865861
112Broad metatarsal (HP:0001783)1.90504612
113Bronchomalacia (HP:0002780)1.90156601
114Patchy hypopigmentation of hair (HP:0011365)1.89780682
115Median cleft lip (HP:0000161)1.89344723
116Abnormality of the pulmonary veins (HP:0011718)1.88787071
117Cutaneous finger syndactyly (HP:0010554)1.88596394
118Large hands (HP:0001176)1.87998599
119Atrophic scars (HP:0001075)1.87804342
120Hypoplasia of the ulna (HP:0003022)1.87794479
121Maternal diabetes (HP:0009800)1.87026050
122Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.86492154
123Cutaneous syndactyly (HP:0012725)1.86464776
124Anomalous pulmonary venous return (HP:0010772)1.86310792
125Preaxial hand polydactyly (HP:0001177)1.85541886
126Anophthalmia (HP:0000528)1.85470296
127Abnormality of the middle phalanges of the toes (HP:0010183)1.85186949
128Turricephaly (HP:0000262)1.84676889
129Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.83996461
130Short 4th metacarpal (HP:0010044)1.83996461
131Severe muscular hypotonia (HP:0006829)1.83744752
132Optic disc pallor (HP:0000543)1.83681477
133Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.81983327
134Aplasia/Hypoplasia of the ulna (HP:0006495)1.81270294
135Narrow nasal bridge (HP:0000446)1.80647702
136Rocker bottom foot (HP:0001838)1.79237850
137Gait imbalance (HP:0002141)1.78826492
138Thin ribs (HP:0000883)1.78787411
139Absent speech (HP:0001344)1.78388214
140Abnormality of the calcaneus (HP:0008364)1.77732664
141Hypoventilation (HP:0002791)1.77709527
142Brushfield spots (HP:0001088)1.77513921
143Congenital primary aphakia (HP:0007707)1.77108212
144Myelomeningocele (HP:0002475)1.76888876
145Foot dorsiflexor weakness (HP:0009027)1.76028977
146Limb-girdle muscle atrophy (HP:0003797)1.74282663
147Nuclear cataract (HP:0100018)1.73902800
148Ureteral stenosis (HP:0000071)1.73666796
149Pulmonary artery stenosis (HP:0004415)1.73543997
150Abnormality of the epiphyses of the hand (HP:0005924)1.73348307
151Adrenal hypoplasia (HP:0000835)1.72918211
152Thickened helices (HP:0000391)1.72592062
153Aplasia/Hypoplasia of the lens (HP:0008063)1.72365915
154Erectile abnormalities (HP:0100639)1.72257496
155Abnormality of the calf musculature (HP:0001430)1.71735231
156Preaxial foot polydactyly (HP:0001841)1.71566629
157Abnormality of the foot musculature (HP:0001436)1.71466791
158Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.71004556
159Preauricular pit (HP:0004467)1.70927332
160Periauricular skin pits (HP:0100277)1.70927332
161Mildly elevated creatine phosphokinase (HP:0008180)1.70720890
162Decreased lacrimation (HP:0000633)1.70530030
163Soft skin (HP:0000977)1.70402967
164Short hallux (HP:0010109)1.69977849
165Male pseudohermaphroditism (HP:0000037)1.68532563
166Vitreoretinal degeneration (HP:0000655)1.68421996
167Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.68328909
168Renal hypoplasia (HP:0000089)1.67072116
169Short middle phalanx of the 5th finger (HP:0004220)1.66188064
170Steatorrhea (HP:0002570)1.66160391
171Fragile skin (HP:0001030)1.66129557
172Partial duplication of the phalanx of hand (HP:0009999)1.65904354
173Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.65890283
174Abnormality of the columella (HP:0009929)1.65417487
175Ankle contracture (HP:0006466)1.64906891
176Nephrogenic diabetes insipidus (HP:0009806)1.64885702
177Wide intermamillary distance (HP:0006610)1.64603772
178Abnormality of the diencephalon (HP:0010662)1.64518827
179Abnormality of the parietal bone (HP:0002696)1.63826063
180Mitral valve prolapse (HP:0001634)1.63355771
181Exercise-induced muscle cramps (HP:0003710)1.61440934
182Camptodactyly of toe (HP:0001836)1.60939104
183Partial duplication of thumb phalanx (HP:0009944)1.60633561
184Arnold-Chiari malformation (HP:0002308)1.59505382
185Polymicrogyria (HP:0002126)1.57791982
186Vertebral hypoplasia (HP:0008417)1.56438701
187Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.56438701
188Increased variability in muscle fiber diameter (HP:0003557)1.56062598
189Spinal cord lesions (HP:0100561)1.53991995
190Syringomyelia (HP:0003396)1.53991995
191Action tremor (HP:0002345)1.53241367

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK8.81898539
2TAOK15.64804565
3MAP3K34.61632473
4MUSK4.41614295
5MAP3K113.87260012
6TLK13.81417211
7MAP2K33.75223802
8PRPF4B2.78574671
9TNIK2.73382552
10ABL22.47854789
11BLK2.41310150
12NTRK12.31128459
13AKT32.13134381
14LATS22.00151658
15JAK31.80689962
16SRPK11.77548068
17STK161.70579753
18LMTK21.67991478
19PAK61.66688262
20NEK61.65647049
21CDK191.61342960
22PDGFRA1.59146354
23EPHA41.54852823
24MAP2K71.49373323
25* MKNK21.41081535
26FES1.38827455
27YES11.36727028
28RIPK11.31888185
29PTK21.31817853
30MAP3K51.31761325
31PLK21.27045462
32MAPK131.25777625
33WEE11.25764627
34TSSK61.23048284
35FER1.22462062
36OXSR11.18883417
37PNCK1.17566906
38MET1.14560901
39PKN11.14267552
40BMPR21.13010587
41LATS11.12881055
42NTRK31.09454372
43MARK11.05785856
44MST41.04925092
45ERBB41.02732854
46PAK21.02312216
47CHEK20.98935026
48NME10.98065561
49TTN0.97620883
50STK390.93383959
51SGK20.91897464
52IRAK10.91463366
53CAMK2B0.91176561
54CDK80.90475517
55CDK30.89953454
56MAP3K10.88704190
57ERBB30.88392291
58MAP3K80.86786858
59GRK70.86650694
60* MKNK10.85964551
61ADRBK20.81969274
62NLK0.81095562
63PRKCE0.81048788
64STK240.80254660
65EIF2AK20.80019202
66GRK10.79913916
67SGK2230.79613813
68SGK4940.79613813
69BRAF0.76652932
70STK38L0.76059484
71EPHB20.75134441
72LIMK10.75007306
73DMPK0.74288637
74NUAK10.74126134
75MAPK150.73165518
76CAMK2A0.73012129
77PAK40.71475209
78DDR20.70420331
79FLT30.67713941
80UHMK10.66584581
81VRK10.66533976
82BMPR1B0.66305890
83EPHA30.66257761
84TYRO30.64857766
85PRKD30.63262803
86TNK20.62294005
87ZAK0.61915483
88PHKG10.61311635
89PHKG20.61311635
90PBK0.61175965
91TIE10.60800332
92CDK150.59820118
93NEK90.59628049
94CDK180.59390121
95INSRR0.59061471
96PRKD20.57934854
97CAMK2D0.57030347
98GRK50.56363189
99ROCK20.55545007
100CDK11A0.55511899
101CLK10.55343809
102NTRK20.54583747
103PRKCI0.53140410
104FGR0.51295748
105MARK20.50294819
106IRAK20.49826403
107BCR0.49763519
108PRKCG0.48579768
109PIM20.48277824
110DYRK20.45687316
111PRKAA20.45187449
112DYRK1B0.45112917
113CAMK2G0.44845154
114PDGFRB0.44585748
115MAPK70.43373405
116OBSCN0.43244968
117CAMK10.42425026
118PRKG10.41652720
119FGFR10.40356448
120EPHA20.40056831
121NEK10.39727022
122BRSK10.39211552
123MAPK120.39130603
124IRAK30.38814446
125PLK30.38653911
126PDK20.38510892
127GSK3A0.38156668
128PRKACA0.37632867
129SGK10.36762436
130TAOK20.36673037
131AURKA0.36642506
132CDK50.35187112
133ADRBK10.33572745
134MAPK100.32095212
135MYLK0.31906799
136ROCK10.31128325
137PIK3CA0.30139390
138ICK0.29436013
139CSNK1A10.29007887
140MAP3K120.28476226
141BMX0.28192170
142MOS0.26443457
143* DYRK1A0.26298019
144IGF1R0.25610611
145EPHB10.25040117
146KSR10.23971147
147PAK10.23435551
148CDK60.22384485
149BRSK20.22330910
150CDK140.22239232
151CSNK1E0.22035973
152STK30.21992712
153TRIM280.21927673
154MTOR0.20662433
155WNK10.20631445
156PRKG20.20485622
157RPS6KA50.20097202
158CSNK1G20.19175174
159CSNK1G10.16709564
160ABL10.15791331
161ERBB20.14847781

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.53513478
2SNARE interactions in vesicular transport_Homo sapiens_hsa041303.40842784
3Nicotine addiction_Homo sapiens_hsa050333.38997664
4Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.61269639
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.53046770
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.35768330
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.17274992
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.11259503
9Taste transduction_Homo sapiens_hsa047422.02296063
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.00860462
11Lysine degradation_Homo sapiens_hsa003101.91543790
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.90825077
13Glutamatergic synapse_Homo sapiens_hsa047241.90467777
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.87704911
15Amoebiasis_Homo sapiens_hsa051461.81775469
16Morphine addiction_Homo sapiens_hsa050321.79101071
17Axon guidance_Homo sapiens_hsa043601.78813557
18Long-term depression_Homo sapiens_hsa047301.78313202
19Serotonergic synapse_Homo sapiens_hsa047261.75119130
20Sphingolipid metabolism_Homo sapiens_hsa006001.70124568
21Fanconi anemia pathway_Homo sapiens_hsa034601.62817601
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.59667341
23GABAergic synapse_Homo sapiens_hsa047271.57478328
24Basal cell carcinoma_Homo sapiens_hsa052171.56200329
25Wnt signaling pathway_Homo sapiens_hsa043101.56112371
26Focal adhesion_Homo sapiens_hsa045101.55969347
27Circadian entrainment_Homo sapiens_hsa047131.53951998
28Oxidative phosphorylation_Homo sapiens_hsa001901.51370719
29Circadian rhythm_Homo sapiens_hsa047101.49668454
30Melanogenesis_Homo sapiens_hsa049161.45984371
31RNA polymerase_Homo sapiens_hsa030201.42745841
32Salivary secretion_Homo sapiens_hsa049701.42498201
33Protein digestion and absorption_Homo sapiens_hsa049741.40968896
34Melanoma_Homo sapiens_hsa052181.38706277
35Amphetamine addiction_Homo sapiens_hsa050311.36887240
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.36340673
37Hedgehog signaling pathway_Homo sapiens_hsa043401.35356474
38Long-term potentiation_Homo sapiens_hsa047201.34940716
39Basal transcription factors_Homo sapiens_hsa030221.34923720
40Prion diseases_Homo sapiens_hsa050201.34758451
41Protein export_Homo sapiens_hsa030601.33953697
42Calcium signaling pathway_Homo sapiens_hsa040201.33443260
43Olfactory transduction_Homo sapiens_hsa047401.27827264
44Proteoglycans in cancer_Homo sapiens_hsa052051.19814723
45beta-Alanine metabolism_Homo sapiens_hsa004101.18445679
46Propanoate metabolism_Homo sapiens_hsa006401.15984318
47Arachidonic acid metabolism_Homo sapiens_hsa005901.13191338
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11892836
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11338025
50Adherens junction_Homo sapiens_hsa045201.11171654
51Homologous recombination_Homo sapiens_hsa034401.10642823
52Huntingtons disease_Homo sapiens_hsa050161.06107255
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.05670789
54Dopaminergic synapse_Homo sapiens_hsa047280.99752560
55Ether lipid metabolism_Homo sapiens_hsa005650.96437326
56Insulin secretion_Homo sapiens_hsa049110.96400853
57Alzheimers disease_Homo sapiens_hsa050100.95819811
58Renin secretion_Homo sapiens_hsa049240.91867418
59Notch signaling pathway_Homo sapiens_hsa043300.90820262
60Ras signaling pathway_Homo sapiens_hsa040140.90484286
61cAMP signaling pathway_Homo sapiens_hsa040240.90098931
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89631517
63Fatty acid metabolism_Homo sapiens_hsa012120.89546274
64Hippo signaling pathway_Homo sapiens_hsa043900.88881360
65Gap junction_Homo sapiens_hsa045400.88694880
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87708075
67Cocaine addiction_Homo sapiens_hsa050300.87548691
68ECM-receptor interaction_Homo sapiens_hsa045120.87274892
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.86081309
70Oxytocin signaling pathway_Homo sapiens_hsa049210.84161395
71ErbB signaling pathway_Homo sapiens_hsa040120.84073693
72Cardiac muscle contraction_Homo sapiens_hsa042600.83953427
73Estrogen signaling pathway_Homo sapiens_hsa049150.83596449
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83079730
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82618297
76Cholinergic synapse_Homo sapiens_hsa047250.82455924
77Glycerolipid metabolism_Homo sapiens_hsa005610.82314273
78TGF-beta signaling pathway_Homo sapiens_hsa043500.82254403
79Spliceosome_Homo sapiens_hsa030400.81986387
80Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81752529
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81327435
82Synaptic vesicle cycle_Homo sapiens_hsa047210.80382217
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80305557
84Gastric acid secretion_Homo sapiens_hsa049710.78843741
85Parkinsons disease_Homo sapiens_hsa050120.78481259
86Collecting duct acid secretion_Homo sapiens_hsa049660.76622343
87Fatty acid elongation_Homo sapiens_hsa000620.76019699
88AMPK signaling pathway_Homo sapiens_hsa041520.74538502
89Dilated cardiomyopathy_Homo sapiens_hsa054140.72039752
90Vibrio cholerae infection_Homo sapiens_hsa051100.71775126
91MAPK signaling pathway_Homo sapiens_hsa040100.71361255
92Small cell lung cancer_Homo sapiens_hsa052220.67517542
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67316406
94Ribosome_Homo sapiens_hsa030100.67249629
95Bile secretion_Homo sapiens_hsa049760.66575356
96Rap1 signaling pathway_Homo sapiens_hsa040150.66424240
97Thyroid hormone synthesis_Homo sapiens_hsa049180.66028157
98Fatty acid degradation_Homo sapiens_hsa000710.65861916
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65027555
100Biosynthesis of amino acids_Homo sapiens_hsa012300.64908463
101Prostate cancer_Homo sapiens_hsa052150.64821843
102Butanoate metabolism_Homo sapiens_hsa006500.64642289
103Bladder cancer_Homo sapiens_hsa052190.64586160
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64531446
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63878194
106Dorso-ventral axis formation_Homo sapiens_hsa043200.62097478
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62038671
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.61880233
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61564939
110Glioma_Homo sapiens_hsa052140.61394004
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60595890
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60438427
113Choline metabolism in cancer_Homo sapiens_hsa052310.60229130
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.59985064
115African trypanosomiasis_Homo sapiens_hsa051430.59767077
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59674366
117Purine metabolism_Homo sapiens_hsa002300.59384651
118Carbon metabolism_Homo sapiens_hsa012000.58544931
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57797420
120Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57781602
121Colorectal cancer_Homo sapiens_hsa052100.56060733
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55084270
123Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54940376
124Pathways in cancer_Homo sapiens_hsa052000.53330244
125GnRH signaling pathway_Homo sapiens_hsa049120.53207518
126Autoimmune thyroid disease_Homo sapiens_hsa053200.52662465
127Alcoholism_Homo sapiens_hsa050340.52507376
128PPAR signaling pathway_Homo sapiens_hsa033200.51653488
129Nitrogen metabolism_Homo sapiens_hsa009100.51575751
130Salmonella infection_Homo sapiens_hsa051320.51257727
131Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50176337
132Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49882031
133Steroid biosynthesis_Homo sapiens_hsa001000.49441756
134Rheumatoid arthritis_Homo sapiens_hsa053230.48865999
135One carbon pool by folate_Homo sapiens_hsa006700.46584767
136Tight junction_Homo sapiens_hsa045300.44562794
137Oocyte meiosis_Homo sapiens_hsa041140.44562310
1382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44343449
139* MicroRNAs in cancer_Homo sapiens_hsa052060.41602943
140Nucleotide excision repair_Homo sapiens_hsa034200.40640931
141Malaria_Homo sapiens_hsa051440.37990158
142Non-homologous end-joining_Homo sapiens_hsa034500.37499918
143Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36864310
144Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36501883
145Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36043667

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