SPRY3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.50675583
2neuronal action potential propagation (GO:0019227)5.18407820
3synaptic vesicle exocytosis (GO:0016079)5.03276745
4vocalization behavior (GO:0071625)4.83691556
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.73119319
6tachykinin receptor signaling pathway (GO:0007217)4.68811564
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.61390631
8neuron cell-cell adhesion (GO:0007158)4.58386720
9ionotropic glutamate receptor signaling pathway (GO:0035235)4.49614401
10regulation of synaptic vesicle exocytosis (GO:2000300)4.48174057
11negative regulation of translation, ncRNA-mediated (GO:0040033)4.45590534
12regulation of translation, ncRNA-mediated (GO:0045974)4.45590534
13negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.45590534
14synaptic vesicle maturation (GO:0016188)4.41341423
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.39250694
16protein localization to synapse (GO:0035418)4.33888511
17glutamate receptor signaling pathway (GO:0007215)4.31734756
18glutamate secretion (GO:0014047)4.29936408
19neurotransmitter secretion (GO:0007269)4.19459902
20positive regulation of action potential (GO:0045760)4.12554218
21synaptic transmission, glutamatergic (GO:0035249)4.12463930
22gamma-aminobutyric acid signaling pathway (GO:0007214)4.12178521
23neuron-neuron synaptic transmission (GO:0007270)4.12015168
24locomotory exploration behavior (GO:0035641)4.11776351
25regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.02820819
26regulation of glutamate receptor signaling pathway (GO:1900449)4.00872965
27negative regulation of synaptic transmission, GABAergic (GO:0032229)3.90170308
28regulation of synaptic vesicle transport (GO:1902803)3.89497203
29G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.81767459
30peptidyl-threonine dephosphorylation (GO:0035970)3.81008833
31regulation of collateral sprouting (GO:0048670)3.80725141
32cAMP catabolic process (GO:0006198)3.79823624
33gamma-aminobutyric acid transport (GO:0015812)3.76965029
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.74058922
35cerebellar granule cell differentiation (GO:0021707)3.72606055
36cerebellar Purkinje cell differentiation (GO:0021702)3.71961762
37opioid receptor signaling pathway (GO:0038003)3.68478371
38exploration behavior (GO:0035640)3.66972747
39neuron recognition (GO:0008038)3.65862280
40cellular potassium ion homeostasis (GO:0030007)3.64114530
41neurotransmitter transport (GO:0006836)3.63989868
42central nervous system projection neuron axonogenesis (GO:0021952)3.63608813
43positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.63012436
44serotonin metabolic process (GO:0042428)3.60990503
45transmission of nerve impulse (GO:0019226)3.58360923
46presynaptic membrane organization (GO:0097090)3.56411270
47presynaptic membrane assembly (GO:0097105)3.52797129
48regulation of long-term neuronal synaptic plasticity (GO:0048169)3.52208006
49regulation of excitatory postsynaptic membrane potential (GO:0060079)3.51258405
50cyclic nucleotide catabolic process (GO:0009214)3.49364271
51regulation of neuronal synaptic plasticity (GO:0048168)3.49120973
52pyrimidine nucleobase catabolic process (GO:0006208)3.48862204
53retinal cone cell development (GO:0046549)3.46680215
54urinary tract smooth muscle contraction (GO:0014848)3.46564803
55neuromuscular process controlling posture (GO:0050884)3.45764457
56regulation of postsynaptic membrane potential (GO:0060078)3.45537284
57regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.44299505
58synaptic vesicle docking involved in exocytosis (GO:0016081)3.43753753
59central nervous system neuron axonogenesis (GO:0021955)3.43597469
60layer formation in cerebral cortex (GO:0021819)3.39313023
61positive regulation of synapse assembly (GO:0051965)3.35780383
62detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.35766431
63detection of temperature stimulus involved in sensory perception (GO:0050961)3.35766431
64behavioral response to pain (GO:0048266)3.35593679
65righting reflex (GO:0060013)3.34347802
66negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.32963033
67regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.31692559
68cell migration in hindbrain (GO:0021535)3.31654471
69axonal fasciculation (GO:0007413)3.31630720
70regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.31251398
71response to histamine (GO:0034776)3.31036472
72regulation of action potential (GO:0098900)3.28311741
73dendritic spine morphogenesis (GO:0060997)3.27920065
74positive regulation of membrane potential (GO:0045838)3.27843800
75membrane depolarization during action potential (GO:0086010)3.27443744
76regulation of neurotransmitter levels (GO:0001505)3.26967157
77long-term memory (GO:0007616)3.26870926
78adult walking behavior (GO:0007628)3.26646141
79membrane hyperpolarization (GO:0060081)3.23434647
80neuronal action potential (GO:0019228)3.21880755
81regulation of synaptic transmission, glutamatergic (GO:0051966)3.18877906
82behavioral fear response (GO:0001662)3.18266825
83behavioral defense response (GO:0002209)3.18266825
84synaptic vesicle endocytosis (GO:0048488)3.15259314
85primary amino compound metabolic process (GO:1901160)3.14487740
86regulation of vesicle fusion (GO:0031338)3.14351526
87regulation of neurotransmitter secretion (GO:0046928)3.12778726
88membrane depolarization (GO:0051899)3.12204159
89negative regulation of cytosolic calcium ion concentration (GO:0051481)3.11236191
90L-amino acid import (GO:0043092)3.11189980
91neurotransmitter-gated ion channel clustering (GO:0072578)3.10695140
92fear response (GO:0042596)3.09738183
93startle response (GO:0001964)3.08293921
94behavioral response to cocaine (GO:0048148)3.07955129
95regulation of voltage-gated calcium channel activity (GO:1901385)3.07801446
96innervation (GO:0060384)3.07315735
97inositol phosphate catabolic process (GO:0071545)3.07138897
98negative regulation of dendrite development (GO:2000171)3.05386985
99sodium ion export (GO:0071436)3.04561834
100long-term synaptic potentiation (GO:0060291)3.02807884
101synapse assembly (GO:0007416)3.01374840
102L-fucose catabolic process (GO:0042355)3.00409020
103fucose catabolic process (GO:0019317)3.00409020
104L-fucose metabolic process (GO:0042354)3.00409020
105detection of temperature stimulus (GO:0016048)2.98881381
106positive regulation of synapse maturation (GO:0090129)2.98288192
107regulation of synapse structural plasticity (GO:0051823)2.98222611
108negative regulation of dendrite morphogenesis (GO:0050774)2.97293330
109protein-cofactor linkage (GO:0018065)2.96330954
110regulation of synaptic plasticity (GO:0048167)2.96303611
111regulation of respiratory system process (GO:0044065)2.94166822
112cell differentiation in hindbrain (GO:0021533)2.94106438
113nucleobase catabolic process (GO:0046113)2.92034988
114regulation of neurotransmitter transport (GO:0051588)2.91293095
115cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.91290408
116regulation of glutamate secretion (GO:0014048)2.90860510
117neuromuscular process controlling balance (GO:0050885)2.90315174
118rhodopsin mediated signaling pathway (GO:0016056)2.90249652
119regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.90238904
120C4-dicarboxylate transport (GO:0015740)2.90114243
121chemosensory behavior (GO:0007635)2.88563465
122regulation of dendritic spine morphogenesis (GO:0061001)2.88331861
123synaptic transmission (GO:0007268)2.87727199
124positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.86539610
125regulation of rhodopsin mediated signaling pathway (GO:0022400)2.86307772
126behavioral response to ethanol (GO:0048149)2.83703866
127positive regulation of uterine smooth muscle contraction (GO:0070474)2.83577872
128response to auditory stimulus (GO:0010996)2.83428186
129proline transport (GO:0015824)2.83170415
130positive regulation of synaptic transmission, GABAergic (GO:0032230)2.83151956
131dendrite morphogenesis (GO:0048813)2.82764250
132postsynaptic membrane organization (GO:0001941)2.82567098
133regulation of synaptic transmission, GABAergic (GO:0032228)2.82228244
134prepulse inhibition (GO:0060134)2.79918544
135learning (GO:0007612)2.79677728
136relaxation of cardiac muscle (GO:0055119)2.78876621
137cell communication by electrical coupling (GO:0010644)2.75124156
138cAMP metabolic process (GO:0046058)2.74314778
139positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.66635127
140cellular response to ATP (GO:0071318)2.64987838
141polyol catabolic process (GO:0046174)2.63261903
142neurofilament cytoskeleton organization (GO:0060052)2.61573498
143negative regulation of neurotransmitter transport (GO:0051589)2.60504275
144aggressive behavior (GO:0002118)2.59890737
145establishment of protein localization to Golgi (GO:0072600)2.55960588
146positive regulation of digestive system process (GO:0060456)2.55328696
147reflex (GO:0060004)2.54086224
148magnesium ion transport (GO:0015693)2.52633536
149positive regulation of glycolytic process (GO:0045821)2.52454787
150adaptation of signaling pathway (GO:0023058)2.50332870
151glycosphingolipid biosynthetic process (GO:0006688)2.48656463
152positive regulation of dendritic spine morphogenesis (GO:0061003)2.47022800
153phosphorylated carbohydrate dephosphorylation (GO:0046838)2.46650179
154inositol phosphate dephosphorylation (GO:0046855)2.46650179
155regulation of dendritic spine development (GO:0060998)2.42974121
156spinal cord association neuron differentiation (GO:0021527)2.41560989

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.80442575
2GBX2_23144817_ChIP-Seq_PC3_Human3.90722770
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.23282769
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.20042538
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.16323766
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.83272573
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.83272573
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.77724280
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.69635719
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.65821995
11REST_21632747_ChIP-Seq_MESCs_Mouse2.62546544
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.60821599
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.58186460
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.54362635
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.47458038
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44480380
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.27615978
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.24767557
19TAF15_26573619_Chip-Seq_HEK293_Human2.23213584
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20959479
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.19667416
22DROSHA_22980978_ChIP-Seq_HELA_Human2.15543466
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.14342630
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.14088730
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09421284
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.07144513
27* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05252633
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90586781
29* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89861416
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.84933873
31* ZNF274_21170338_ChIP-Seq_K562_Hela1.81191807
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.80128114
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.78778987
34AR_21572438_ChIP-Seq_LNCaP_Human1.78261389
35SMAD4_21799915_ChIP-Seq_A2780_Human1.76081306
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71865169
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70227311
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68517683
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.65300182
40EWS_26573619_Chip-Seq_HEK293_Human1.62801835
41P300_19829295_ChIP-Seq_ESCs_Human1.59097164
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55873509
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54526250
44TP53_16413492_ChIP-PET_HCT116_Human1.54183512
45* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47267712
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.46811752
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45150884
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44479852
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44228030
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43834502
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43529835
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.43474852
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.41936876
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40921028
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40529276
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.39627856
57* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38400704
58RNF2_27304074_Chip-Seq_NSC_Mouse1.37597771
59CBP_20019798_ChIP-Seq_JUKART_Human1.36412748
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36412748
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.36124342
62TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.36007673
63EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35882318
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34460849
65CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.30243013
66* VDR_22108803_ChIP-Seq_LS180_Human1.29699641
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28652609
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.28422426
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26692693
70AR_25329375_ChIP-Seq_VCAP_Human1.26382743
71STAT3_23295773_ChIP-Seq_U87_Human1.25919409
72* SOX2_21211035_ChIP-Seq_LN229_Gbm1.25165030
73GATA1_26923725_Chip-Seq_HPCs_Mouse1.24448970
74* IGF1R_20145208_ChIP-Seq_DFB_Human1.22604708
75RING1B_27294783_Chip-Seq_ESCs_Mouse1.20414833
76SMAD3_21741376_ChIP-Seq_HESCs_Human1.18498820
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18451557
78* ER_23166858_ChIP-Seq_MCF-7_Human1.16585525
79AR_19668381_ChIP-Seq_PC3_Human1.14695470
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12351744
81ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11805182
82RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.11646748
83P53_22387025_ChIP-Seq_ESCs_Mouse1.11363407
84LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11071914
85* RXR_22108803_ChIP-Seq_LS180_Human1.11009776
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.10619046
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08901541
88EP300_21415370_ChIP-Seq_HL-1_Mouse1.08807805
89PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08481533
90TCF4_23295773_ChIP-Seq_U87_Human1.07752457
91* FUS_26573619_Chip-Seq_HEK293_Human1.07446639
92SMAD_19615063_ChIP-ChIP_OVARY_Human1.07357668
93RING1B_27294783_Chip-Seq_NPCs_Mouse1.07006266
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06937518
95NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06937518
96* RUNX2_22187159_ChIP-Seq_PCA_Human1.06767662
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06653349
98RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06408389
99GATA1_22025678_ChIP-Seq_K562_Human1.06270169
100TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05818821
101KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05369880
102P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02953659
103* BCAT_22108803_ChIP-Seq_LS180_Human1.02521007
104PRDM14_20953172_ChIP-Seq_ESCs_Human1.01649643
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01637159
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00424250
107JUN_21703547_ChIP-Seq_K562_Human1.00243841
108ARNT_22903824_ChIP-Seq_MCF-7_Human0.97290619
109CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97128134
110YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96095293
111AHR_22903824_ChIP-Seq_MCF-7_Human0.94638054
112DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94159847
113WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93628961
114NANOG_18555785_Chip-Seq_ESCs_Mouse0.92387062
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92178010
116CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.92139924
117SMAD3_21741376_ChIP-Seq_ESCs_Human0.91862807
118NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91007886
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90047856
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90047856
121TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88325375
122KDM2B_26808549_Chip-Seq_REH_Human0.87303546
123GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86491533
124ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85006047
125TP53_18474530_ChIP-ChIP_U2OS_Human0.84799240
126STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.83473165
127SMAD4_21741376_ChIP-Seq_HESCs_Human0.83145880

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.28595926
2MP0003880_abnormal_central_pattern4.45685360
3MP0003635_abnormal_synaptic_transmissio3.78462027
4MP0004270_analgesia3.78121125
5MP0009046_muscle_twitch3.60136640
6MP0001968_abnormal_touch/_nociception3.34456284
7MP0009745_abnormal_behavioral_response3.22909409
8MP0002064_seizures3.07415977
9MP0002735_abnormal_chemical_nociception3.00817291
10MP0002272_abnormal_nervous_system2.98089727
11MP0002063_abnormal_learning/memory/cond2.93829224
12MP0000569_abnormal_digit_pigmentation2.90130383
13MP0002734_abnormal_mechanical_nocicepti2.79188385
14MP0002736_abnormal_nociception_after2.74795525
15MP0006276_abnormal_autonomic_nervous2.72797765
16MP0005423_abnormal_somatic_nervous2.71770534
17MP0002572_abnormal_emotion/affect_behav2.69297140
18MP0008877_abnormal_DNA_methylation2.56431819
19MP0001486_abnormal_startle_reflex2.49821168
20MP0002067_abnormal_sensory_capabilities2.24429280
21MP0001440_abnormal_grooming_behavior2.24331636
22MP0002733_abnormal_thermal_nociception2.22118372
23MP0002184_abnormal_innervation2.19640466
24MP0001501_abnormal_sleep_pattern2.14683278
25MP0005551_abnormal_eye_electrophysiolog2.08389343
26MP0001970_abnormal_pain_threshold2.06706491
27MP0003724_increased_susceptibility_to2.06627641
28MP0002822_catalepsy1.98771864
29MP0004142_abnormal_muscle_tone1.94645639
30MP0003646_muscle_fatigue1.87065132
31MP0000778_abnormal_nervous_system1.82333013
32MP0008569_lethality_at_weaning1.81097026
33MP0003183_abnormal_peptide_metabolism1.74389116
34MP0004924_abnormal_behavior1.74231079
35MP0005386_behavior/neurological_phenoty1.74231079
36MP0000427_abnormal_hair_cycle1.73036544
37MP0002557_abnormal_social/conspecific_i1.67918619
38MP0003329_amyloid_beta_deposits1.67219557
39MP0003122_maternal_imprinting1.61527675
40MP0002882_abnormal_neuron_morphology1.61335196
41MP0001984_abnormal_olfaction1.60235200
42MP0000955_abnormal_spinal_cord1.60170978
43MP0004858_abnormal_nervous_system1.56417268
44MP0004811_abnormal_neuron_physiology1.52827607
45MP0001905_abnormal_dopamine_level1.51668195
46MP0003890_abnormal_embryonic-extraembry1.50473481
47MP0001529_abnormal_vocalization1.48101971
48MP0002277_abnormal_respiratory_mucosa1.44781320
49MP0004742_abnormal_vestibular_system1.44763637
50MP0002066_abnormal_motor_capabilities/c1.44566843
51MP0004130_abnormal_muscle_cell1.41584223
52MP0001188_hyperpigmentation1.41244965
53MP0002229_neurodegeneration1.39984987
54MP0006072_abnormal_retinal_apoptosis1.39670587
55MP0002102_abnormal_ear_morphology1.36349729
56MP0008775_abnormal_heart_ventricle1.31319215
57MP0000639_abnormal_adrenal_gland1.24426183
58MP0001502_abnormal_circadian_rhythm1.23588321
59MP0004084_abnormal_cardiac_muscle1.17271727
60MP0010352_gastrointestinal_tract_polyps1.15532529
61MP0004885_abnormal_endolymph1.14365927
62MP0005253_abnormal_eye_physiology1.14273906
63MP0002752_abnormal_somatic_nervous1.14066734
64MP0000920_abnormal_myelination1.13169796
65MP0002909_abnormal_adrenal_gland1.12589131
66MP0002152_abnormal_brain_morphology1.06600130
67MP0003787_abnormal_imprinting1.04354904
68MP0009780_abnormal_chondrocyte_physiolo1.03972934
69MP0005646_abnormal_pituitary_gland1.02509167
70MP0000538_abnormal_urinary_bladder1.02126635
71MP0003879_abnormal_hair_cell1.02112099
72MP0002837_dystrophic_cardiac_calcinosis1.02069831
73MP0003633_abnormal_nervous_system1.02046563
74MP0004043_abnormal_pH_regulation1.01522479
75MP0004145_abnormal_muscle_electrophysio1.00823768
76MP0005670_abnormal_white_adipose1.00686620
77MP0000230_abnormal_systemic_arterial1.00401392
78MP0003631_nervous_system_phenotype0.99845834
79MP0003634_abnormal_glial_cell0.99400250
80MP0002282_abnormal_trachea_morphology0.98956996
81MP0002254_reproductive_system_inflammat0.98010395
82MP0003632_abnormal_nervous_system0.97332268
83MP0001963_abnormal_hearing_physiology0.96874813
84MP0000751_myopathy0.95395255
85MP0003121_genomic_imprinting0.94466158
86MP0009764_decreased_sensitivity_to0.93872069
87MP0005645_abnormal_hypothalamus_physiol0.93808088
88MP0001986_abnormal_taste_sensitivity0.92506371
89MP0001299_abnormal_eye_distance/0.92281313
90MP0005187_abnormal_penis_morphology0.90969903
91MP0005394_taste/olfaction_phenotype0.90065457
92MP0005499_abnormal_olfactory_system0.90065457
93MP0002638_abnormal_pupillary_reflex0.88866430
94MP0000534_abnormal_ureter_morphology0.88049937
95MP0000516_abnormal_urinary_system0.87785984
96MP0005367_renal/urinary_system_phenotyp0.87785984
97MP0005171_absent_coat_pigmentation0.87659880
98MP0008872_abnormal_physiological_respon0.86503922
99MP0002090_abnormal_vision0.85470765
100MP0003195_calcinosis0.84028873
101MP0003828_pulmonary_edema0.83115604
102MP0001485_abnormal_pinna_reflex0.81971771
103MP0005167_abnormal_blood-brain_barrier0.78834752
104MP0002069_abnormal_eating/drinking_beha0.78648699
105MP0004085_abnormal_heartbeat0.78306146
106MP0005195_abnormal_posterior_eye0.77274529
107MP0004233_abnormal_muscle_weight0.76245433
108MP0003136_yellow_coat_color0.75930193
109MP0010386_abnormal_urinary_bladder0.74415808
110MP0002751_abnormal_autonomic_nervous0.73537518
111MP0000013_abnormal_adipose_tissue0.72581195
112MP0001177_atelectasis0.71111431
113MP0003119_abnormal_digestive_system0.70966500
114MP0002332_abnormal_exercise_endurance0.70222348
115MP0005409_darkened_coat_color0.69383247
116MP0000604_amyloidosis0.67963259
117MP0008874_decreased_physiological_sensi0.67597789
118MP0001661_extended_life_span0.66043531
119MP0001943_abnormal_respiration0.65661364
120MP0004484_altered_response_of0.65609069
121MP0000026_abnormal_inner_ear0.65469051
122MP0000647_abnormal_sebaceous_gland0.63802976
123MP0009379_abnormal_foot_pigmentation0.63411340
124MP0004147_increased_porphyrin_level0.62649470
125MP0010678_abnormal_skin_adnexa0.62168408
126MP0003690_abnormal_glial_cell0.61712158
127MP0005535_abnormal_body_temperature0.61642415
128MP0002876_abnormal_thyroid_physiology0.58996366
129MP0004036_abnormal_muscle_relaxation0.58174694
130MP0003861_abnormal_nervous_system0.57757914
131MP0000631_abnormal_neuroendocrine_gland0.57240743
132MP0001664_abnormal_digestion0.57175448
133MP0003045_fibrosis0.56671533
134MP0005623_abnormal_meninges_morphology0.56051806
135MP0002928_abnormal_bile_duct0.55980041
136MP0003137_abnormal_impulse_conducting0.55556811
137MP0004215_abnormal_myocardial_fiber0.55375566
138MP0003115_abnormal_respiratory_system0.54890193
139MP0010770_preweaning_lethality0.52681528

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.00253879
2Myokymia (HP:0002411)5.93767776
3Septo-optic dysplasia (HP:0100842)5.54758739
4Atonic seizures (HP:0010819)5.54593147
5Focal seizures (HP:0007359)5.20761902
6Progressive cerebellar ataxia (HP:0002073)5.07200545
7Febrile seizures (HP:0002373)4.73222458
8Action tremor (HP:0002345)4.43448274
9Absence seizures (HP:0002121)4.32742427
10Dyschromatopsia (HP:0007641)4.32314651
11Epileptic encephalopathy (HP:0200134)4.31996323
12Visual hallucinations (HP:0002367)4.23835458
13Dialeptic seizures (HP:0011146)3.86732978
14Dysdiadochokinesis (HP:0002075)3.47353883
15Generalized tonic-clonic seizures (HP:0002069)3.46927459
16Gaze-evoked nystagmus (HP:0000640)3.41792604
17Optic nerve hypoplasia (HP:0000609)3.41760286
18Broad-based gait (HP:0002136)3.37522903
19Protruding tongue (HP:0010808)3.33340516
20Abnormality of the lower motor neuron (HP:0002366)3.32515177
21Neoplasm of the adrenal cortex (HP:0100641)3.24315738
22Scanning speech (HP:0002168)3.21348424
23Stomach cancer (HP:0012126)3.16766098
24Pheochromocytoma (HP:0002666)3.11547653
25Truncal ataxia (HP:0002078)3.10508410
26Hyperventilation (HP:0002883)3.07731452
27Dysmetria (HP:0001310)3.07583860
28Enlarged penis (HP:0000040)3.01438021
29Disproportionate short-trunk short stature (HP:0003521)2.93397824
30Supranuclear gaze palsy (HP:0000605)2.91646136
31Anxiety (HP:0000739)2.88927983
32Neuroendocrine neoplasm (HP:0100634)2.83927129
33Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.80878130
34Congenital stationary night blindness (HP:0007642)2.80144803
35Impaired vibration sensation in the lower limbs (HP:0002166)2.78065569
36Absent rod-and cone-mediated responses on ERG (HP:0007688)2.76620472
37Absent septum pellucidum (HP:0001331)2.72150398
38Abnormality of the corticospinal tract (HP:0002492)2.71781922
39Amblyopia (HP:0000646)2.68515758
40Depression (HP:0000716)2.64361822
41Abnormality of binocular vision (HP:0011514)2.64098638
42Diplopia (HP:0000651)2.64098638
43Abnormal eating behavior (HP:0100738)2.63539140
44Insidious onset (HP:0003587)2.63038905
45Termporal pattern (HP:0011008)2.63038905
46Spastic gait (HP:0002064)2.61770239
47Hemiparesis (HP:0001269)2.61488139
48Abnormality of the septum pellucidum (HP:0007375)2.60382464
49Limb dystonia (HP:0002451)2.56624938
50Ankle clonus (HP:0011448)2.51726373
51Chorioretinal atrophy (HP:0000533)2.50218651
52Poor eye contact (HP:0000817)2.49337604
53Genetic anticipation (HP:0003743)2.46917879
54Abolished electroretinogram (ERG) (HP:0000550)2.46521832
55Attenuation of retinal blood vessels (HP:0007843)2.46496794
56Growth hormone deficiency (HP:0000824)2.45218181
57Urinary bladder sphincter dysfunction (HP:0002839)2.43977155
58Central scotoma (HP:0000603)2.43263423
59Dyskinesia (HP:0100660)2.42783487
60Gait imbalance (HP:0002141)2.42516633
61Impaired smooth pursuit (HP:0007772)2.39749071
62Progressive inability to walk (HP:0002505)2.37408220
63Abnormal social behavior (HP:0012433)2.35715742
64Impaired social interactions (HP:0000735)2.35715742
65Excessive salivation (HP:0003781)2.35340176
66Drooling (HP:0002307)2.35340176
67Abnormality of macular pigmentation (HP:0008002)2.33480177
68Amyotrophic lateral sclerosis (HP:0007354)2.31115307
69Hypoventilation (HP:0002791)2.30059119
70Degeneration of the lateral corticospinal tracts (HP:0002314)2.29213565
71Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.29213565
72Intention tremor (HP:0002080)2.28975796
73Urinary urgency (HP:0000012)2.27567778
74Cerebral inclusion bodies (HP:0100314)2.24523700
75Bony spicule pigmentary retinopathy (HP:0007737)2.23251360
76Neurofibrillary tangles (HP:0002185)2.21783799
77Absent speech (HP:0001344)2.20130410
78Barrel-shaped chest (HP:0001552)2.19249333
79Acute necrotizing encephalopathy (HP:0006965)2.18703381
80Postural tremor (HP:0002174)2.18003701
81Congenital primary aphakia (HP:0007707)2.16114768
82Truncal obesity (HP:0001956)2.15761946
83Abnormality of ocular smooth pursuit (HP:0000617)2.14719899
84Polyphagia (HP:0002591)2.13308197
85Abnormal mitochondria in muscle tissue (HP:0008316)2.12585002
86Epileptiform EEG discharges (HP:0011182)2.10530794
87Specific learning disability (HP:0001328)2.08511085
88Horizontal nystagmus (HP:0000666)2.08469563
89Abnormality of B cell number (HP:0010975)2.08276611
90Status epilepticus (HP:0002133)2.07427650
91Choroideremia (HP:0001139)2.07179183
92Long nose (HP:0003189)2.06644871
93Hemiplegia (HP:0002301)2.06231690
94Testicular neoplasm (HP:0010788)2.06154014
95Mutism (HP:0002300)2.05618665
96Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.05036520
97Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.03429645
98Bradykinesia (HP:0002067)2.02143271
99Progressive macrocephaly (HP:0004481)2.01423963
100EEG with generalized epileptiform discharges (HP:0011198)2.00620967
101Psychosis (HP:0000709)1.99756441
102Hypothermia (HP:0002045)1.98804239
103Medial flaring of the eyebrow (HP:0010747)1.96073551
104Dysmetric saccades (HP:0000641)1.95780047
105Generalized myoclonic seizures (HP:0002123)1.95048066
106Aqueductal stenosis (HP:0002410)1.94583698
107Agitation (HP:0000713)1.94038837
108Abnormality of salivation (HP:0100755)1.93873064
109Genital tract atresia (HP:0001827)1.93735810
110Vaginal atresia (HP:0000148)1.93312590
111Scotoma (HP:0000575)1.92791901
112Aplasia/Hypoplasia of the sternum (HP:0006714)1.92651686
113Inappropriate behavior (HP:0000719)1.92144196
114Optic disc pallor (HP:0000543)1.91661458
115Clumsiness (HP:0002312)1.91519159
116Pancreatic cysts (HP:0001737)1.90980885
117Ulnar claw (HP:0001178)1.90870869
118Retinal dysplasia (HP:0007973)1.90804219
119True hermaphroditism (HP:0010459)1.90636043
120Exotropia (HP:0000577)1.89559337
121Abnormal rod and cone electroretinograms (HP:0008323)1.89537991
122Failure to thrive in infancy (HP:0001531)1.89321868
123Postural instability (HP:0002172)1.89119008
124Fetal akinesia sequence (HP:0001989)1.88542775
125Poor speech (HP:0002465)1.87546416
126Abnormal hair whorl (HP:0010721)1.87435348
127Hypsarrhythmia (HP:0002521)1.87025656
128Gait ataxia (HP:0002066)1.86229739
129Decreased circulating renin level (HP:0003351)1.86023511
130Delusions (HP:0000746)1.85635918
131Nephrogenic diabetes insipidus (HP:0009806)1.85562792
132Morphological abnormality of the pyramidal tract (HP:0002062)1.83199687
133Impaired vibratory sensation (HP:0002495)1.82824984
134Incomplete penetrance (HP:0003829)1.81026348
135Lower limb muscle weakness (HP:0007340)1.80696939
136Pancreatic fibrosis (HP:0100732)1.80297145
137Neuronal loss in central nervous system (HP:0002529)1.80280613
138Gonadotropin excess (HP:0000837)1.78111631
139Decreased central vision (HP:0007663)1.77283741
140Midline defect of the nose (HP:0004122)1.76894608
141Keratoconus (HP:0000563)1.74716369
142Increased corneal curvature (HP:0100692)1.74716369
143Abnormal delayed hypersensitivity skin test (HP:0002963)1.72641062
144Hepatoblastoma (HP:0002884)1.68897442
145Hypoplastic iliac wings (HP:0002866)1.66923576
146Abnormal auditory evoked potentials (HP:0006958)1.66318870
147Prolonged QT interval (HP:0001657)1.64553085
148Macroorchidism (HP:0000053)1.64262109
149Widely spaced teeth (HP:0000687)1.64018047
150Small hand (HP:0200055)1.63757652
151Type II lissencephaly (HP:0007260)1.63680696
152Hypopigmentation of the fundus (HP:0007894)1.62939278
153Abnormality of midbrain morphology (HP:0002418)1.62038873
154Molar tooth sign on MRI (HP:0002419)1.62038873
155Clonus (HP:0002169)1.60856410
156Syncope (HP:0001279)1.59483179
157Glioma (HP:0009733)1.59144414
158Partial agenesis of the corpus callosum (HP:0001338)1.57011983
159Lissencephaly (HP:0001339)1.56696838
160Menstrual irregularities (HP:0000858)1.55868001
161Sclerocornea (HP:0000647)1.55403726
162Short chin (HP:0000331)1.54322705

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK196.23553613
2FRK6.08166109
3NTRK34.04241947
4EPHA42.98494602
5MAP3K42.94921503
6MINK12.75633010
7MAP3K92.64029857
8MAP2K72.52746507
9CASK2.48743402
10MARK12.26902990
11MAP3K122.22411976
12MAP2K42.14547706
13NTRK12.06230355
14PNCK2.05119757
15MAP3K62.03948371
16TNK21.99261871
17MAP3K141.94201579
18BMPR1B1.87561324
19RIPK41.77980764
20ACVR1B1.65592693
21EIF2AK21.64272805
22NTRK21.62738048
23PAK61.60324064
24ARAF1.52988562
25KSR21.50816155
26OXSR11.44520184
27KSR11.42727796
28TAOK31.42211468
29TIE11.42164910
30GRK51.40473045
31PLK21.39339618
32PRKCG1.39333634
33NME11.31842945
34CDK51.28767103
35MAPK131.28340211
36EIF2AK31.23849046
37STK391.22698920
38TNIK1.22499634
39BCR1.20425164
40CAMK2A1.14954207
41MKNK21.14525055
42PHKG21.12595233
43PHKG11.12595233
44DAPK21.12435291
45YES11.11823106
46IRAK11.10432814
47WNK11.08258074
48UHMK11.06149092
49BRSK21.00016771
50SGK2230.99509473
51SGK4940.99509473
52CAMK2B0.98778150
53PRPF4B0.97380907
54FES0.97259404
55CDK11A0.96372642
56TEC0.95657792
57CDK140.93901798
58CAMKK20.93585591
59DAPK10.92847983
60CAMKK10.90792643
61LATS20.90318129
62CDK180.88529838
63STK380.88507128
64CDK150.84254576
65SIK20.84074141
66LMTK20.83960089
67DYRK20.83825808
68MAP2K60.81240107
69CSNK1G20.80294419
70CAMK2D0.78599832
71PRKD30.77871578
72STK38L0.76803968
73CAMK1D0.75579887
74PTK2B0.75499082
75FGR0.75049646
76PAK30.74149751
77LIMK10.73785413
78GRK70.72659723
79AKT30.72628800
80MAP3K70.71793500
81CAMK2G0.71322780
82CAMK1G0.70957458
83ROCK20.70297990
84INSRR0.70027842
85SGK20.69152925
86PRKCE0.68980107
87PIK3CA0.68055205
88CSNK1G10.66576355
89SIK30.66390002
90NUAK10.66300474
91CSNK1G30.66135959
92MAP2K30.65982211
93PLK30.64648842
94DYRK1A0.64316948
95GRK10.64138525
96ADRBK10.62819226
97CSNK1D0.62155058
98MAP3K20.61410601
99FER0.60217460
100BMPR20.59893048
101PRKCH0.59744499
102NEK60.58058861
103MAP2K20.57911783
104CAMK10.57547593
105MAPK120.56673156
106STK110.55653215
107TYRO30.55648141
108PINK10.55540769
109NLK0.55422066
110TLK10.53505473
111PKN10.53356278
112SCYL20.50824907
113RET0.50149933
114SGK10.49123907
115BRAF0.48809029
116STK160.48681214
117WNK40.47945915
118MAP4K20.47739601
119ITK0.47517782
120WNK30.47505715
121FGFR30.47065907
122PRKCZ0.46837512
123IKBKE0.46547096
124MAPKAPK50.46166077
125MAP3K130.46073921
126MAP2K10.45518225
127PRKG20.45418140
128ADRBK20.45273045
129MARK20.44182671
130RIPK10.44024324
131FGFR20.41940098
132PRKACA0.41510674
133CSNK1A1L0.41040674
134RPS6KB10.40943384
135SGK30.40921099
136RAF10.40053676
137DMPK0.39750625
138PRKG10.39741059
139ZAK0.39078480
140FYN0.38700555
141IRAK20.38360672
142CAMK40.38323099
143CSNK1E0.37586379

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.07824529
2Synaptic vesicle cycle_Homo sapiens_hsa047213.48767745
3Phototransduction_Homo sapiens_hsa047443.12828032
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.88661519
5GABAergic synapse_Homo sapiens_hsa047272.75295696
6Glutamatergic synapse_Homo sapiens_hsa047242.58239958
7Long-term potentiation_Homo sapiens_hsa047202.47710855
8Circadian entrainment_Homo sapiens_hsa047132.46811619
9Morphine addiction_Homo sapiens_hsa050322.44191643
10Olfactory transduction_Homo sapiens_hsa047402.34803648
11Dopaminergic synapse_Homo sapiens_hsa047282.23160083
12Amphetamine addiction_Homo sapiens_hsa050312.21245781
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.10378586
14Collecting duct acid secretion_Homo sapiens_hsa049662.04551579
15Long-term depression_Homo sapiens_hsa047302.01686416
16Taste transduction_Homo sapiens_hsa047421.98226410
17Salivary secretion_Homo sapiens_hsa049701.94672001
18Serotonergic synapse_Homo sapiens_hsa047261.92056434
19Cholinergic synapse_Homo sapiens_hsa047251.77579232
20Oxidative phosphorylation_Homo sapiens_hsa001901.77256642
21Insulin secretion_Homo sapiens_hsa049111.71555106
22Nitrogen metabolism_Homo sapiens_hsa009101.66038845
23Gastric acid secretion_Homo sapiens_hsa049711.61816187
24Renin secretion_Homo sapiens_hsa049241.58171332
25Cardiac muscle contraction_Homo sapiens_hsa042601.53745057
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49095629
27Cocaine addiction_Homo sapiens_hsa050301.47767281
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47686712
29Circadian rhythm_Homo sapiens_hsa047101.46949402
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.46788725
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40988981
32Calcium signaling pathway_Homo sapiens_hsa040201.39583745
33Alzheimers disease_Homo sapiens_hsa050101.39156941
34Parkinsons disease_Homo sapiens_hsa050121.33698827
35Oxytocin signaling pathway_Homo sapiens_hsa049211.33528321
36Gap junction_Homo sapiens_hsa045401.30560078
37Vibrio cholerae infection_Homo sapiens_hsa051101.29053072
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.29042518
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22893679
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21167473
41GnRH signaling pathway_Homo sapiens_hsa049121.20044804
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19413670
43NOD-like receptor signaling pathway_Homo sapiens_hsa046211.12074643
44Axon guidance_Homo sapiens_hsa043601.10127023
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06066899
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06018758
47cAMP signaling pathway_Homo sapiens_hsa040241.03938379
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94933831
49Huntingtons disease_Homo sapiens_hsa050160.89987449
50Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.89920500
51Estrogen signaling pathway_Homo sapiens_hsa049150.88623790
52Melanogenesis_Homo sapiens_hsa049160.83482592
53ErbB signaling pathway_Homo sapiens_hsa040120.83398310
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83255100
55Selenocompound metabolism_Homo sapiens_hsa004500.81403048
56Lysine degradation_Homo sapiens_hsa003100.80378014
57Pancreatic secretion_Homo sapiens_hsa049720.79656959
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.77443335
59African trypanosomiasis_Homo sapiens_hsa051430.76314856
60Glioma_Homo sapiens_hsa052140.76049877
61Oocyte meiosis_Homo sapiens_hsa041140.75461783
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.75331904
63Type II diabetes mellitus_Homo sapiens_hsa049300.74886060
64Thyroid hormone synthesis_Homo sapiens_hsa049180.74784334
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70173338
66Fatty acid biosynthesis_Homo sapiens_hsa000610.69988193
67Ovarian steroidogenesis_Homo sapiens_hsa049130.69892178
68Mineral absorption_Homo sapiens_hsa049780.69735247
69Platelet activation_Homo sapiens_hsa046110.69249551
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65409678
71Glycerolipid metabolism_Homo sapiens_hsa005610.64591052
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63890771
73Chemokine signaling pathway_Homo sapiens_hsa040620.58216245
74FoxO signaling pathway_Homo sapiens_hsa040680.57956259
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57274604
76Choline metabolism in cancer_Homo sapiens_hsa052310.57254590
77MAPK signaling pathway_Homo sapiens_hsa040100.56907806
78Alcoholism_Homo sapiens_hsa050340.56878509
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56245655
80Dilated cardiomyopathy_Homo sapiens_hsa054140.53937835
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53674565
82Dorso-ventral axis formation_Homo sapiens_hsa043200.51982367
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50629963
84Ether lipid metabolism_Homo sapiens_hsa005650.50528482
85Ras signaling pathway_Homo sapiens_hsa040140.50046677
86mTOR signaling pathway_Homo sapiens_hsa041500.49373591
87Renin-angiotensin system_Homo sapiens_hsa046140.49117419
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48370474
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47716405
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46746599
91ABC transporters_Homo sapiens_hsa020100.46602774
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.46193587
93Inositol phosphate metabolism_Homo sapiens_hsa005620.46037870
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45034676
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44152652
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44004750
97Sulfur metabolism_Homo sapiens_hsa009200.43929417
98Endocytosis_Homo sapiens_hsa041440.42173968
99Linoleic acid metabolism_Homo sapiens_hsa005910.41908358
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38673025
101VEGF signaling pathway_Homo sapiens_hsa043700.38556025
102Prolactin signaling pathway_Homo sapiens_hsa049170.38519263
103Rheumatoid arthritis_Homo sapiens_hsa053230.37848330
104Rap1 signaling pathway_Homo sapiens_hsa040150.37586081
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.37476685
106Regulation of autophagy_Homo sapiens_hsa041400.36976767
107Tuberculosis_Homo sapiens_hsa051520.36671662
108Glucagon signaling pathway_Homo sapiens_hsa049220.36532302
109Osteoclast differentiation_Homo sapiens_hsa043800.36115760
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35316077
111Basal transcription factors_Homo sapiens_hsa030220.35018754
112Phagosome_Homo sapiens_hsa041450.34735057
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34015495
114Arginine biosynthesis_Homo sapiens_hsa002200.33292568
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32942408
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32655337
117Bile secretion_Homo sapiens_hsa049760.32439820
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32116717
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31700418
120Butanoate metabolism_Homo sapiens_hsa006500.31610316
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29163725
122Wnt signaling pathway_Homo sapiens_hsa043100.29007216
123Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26319870
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.25981351
125Fatty acid elongation_Homo sapiens_hsa000620.24585435
126Renal cell carcinoma_Homo sapiens_hsa052110.24265033
127Melanoma_Homo sapiens_hsa052180.23746383
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22580827
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.22049986
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21594734
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21427002

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