SPRYD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.29675194
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.04874953
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.63909868
4locomotory exploration behavior (GO:0035641)5.45080096
5synaptic vesicle exocytosis (GO:0016079)5.23864765
6glutamate secretion (GO:0014047)5.13310346
7synaptic vesicle docking involved in exocytosis (GO:0016081)5.05939327
8regulation of synaptic vesicle exocytosis (GO:2000300)4.94323045
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.65081879
10regulation of synaptic vesicle transport (GO:1902803)4.41193241
11vocalization behavior (GO:0071625)4.40099378
12neurotransmitter secretion (GO:0007269)4.27893624
13regulation of neuronal synaptic plasticity (GO:0048168)4.24747254
14neuromuscular process controlling posture (GO:0050884)4.23811278
15layer formation in cerebral cortex (GO:0021819)4.19041111
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.13124286
17activation of protein kinase A activity (GO:0034199)4.12260989
18proline transport (GO:0015824)4.08222761
19regulation of glutamate receptor signaling pathway (GO:1900449)4.05566711
20regulation of synapse structural plasticity (GO:0051823)4.04272959
21exploration behavior (GO:0035640)4.02696336
22L-amino acid import (GO:0043092)3.97743739
23neuromuscular process controlling balance (GO:0050885)3.95656659
24sodium ion export (GO:0071436)3.93041358
25regulation of long-term neuronal synaptic plasticity (GO:0048169)3.92940166
26synaptic vesicle endocytosis (GO:0048488)3.91027836
27positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.81197704
28cerebellar granule cell differentiation (GO:0021707)3.80558128
29amino acid import (GO:0043090)3.78736121
30gamma-aminobutyric acid transport (GO:0015812)3.78352439
31cellular potassium ion homeostasis (GO:0030007)3.74909111
32protein localization to synapse (GO:0035418)3.70803284
33neuronal action potential propagation (GO:0019227)3.67926237
34positive regulation of neurotransmitter secretion (GO:0001956)3.67706415
35positive regulation of synaptic transmission, GABAergic (GO:0032230)3.65171513
36glycine transport (GO:0015816)3.57900078
37cell migration in hindbrain (GO:0021535)3.54195834
38potassium ion homeostasis (GO:0055075)3.53613767
39cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.52963737
40long-term memory (GO:0007616)3.44787956
41cell communication by electrical coupling (GO:0010644)3.33864439
42ionotropic glutamate receptor signaling pathway (GO:0035235)3.32581179
43regulation of cAMP-dependent protein kinase activity (GO:2000479)3.32074068
44negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.31330610
45neuronal ion channel clustering (GO:0045161)3.28795779
46positive regulation of synapse maturation (GO:0090129)3.27642226
47regulation of synaptic plasticity (GO:0048167)3.26198164
48neurotransmitter transport (GO:0006836)3.25022262
49membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.24170317
50negative regulation of dendrite morphogenesis (GO:0050774)3.23893966
51neuromuscular process (GO:0050905)3.21141138
52potassium ion import (GO:0010107)3.20160522
53regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.19098701
54signal complex assembly (GO:0007172)3.18232887
55neurotransmitter-gated ion channel clustering (GO:0072578)3.17384930
56regulation of ARF protein signal transduction (GO:0032012)3.17227674
57vesicle transport along microtubule (GO:0047496)3.14972966
58regulation of voltage-gated calcium channel activity (GO:1901385)3.14495443
59cerebellar Purkinje cell layer development (GO:0021680)3.10722484
60positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.10530887
61synaptic transmission, glutamatergic (GO:0035249)3.10502036
62regulation of excitatory postsynaptic membrane potential (GO:0060079)3.08659956
63regulation of neurotransmitter secretion (GO:0046928)3.06455268
64dendritic spine morphogenesis (GO:0060997)3.05524396
65regulation of neurotransmitter levels (GO:0001505)3.05470076
66detection of calcium ion (GO:0005513)3.05427411
67negative regulation of synaptic transmission, GABAergic (GO:0032229)3.01279276
68regulation of synapse maturation (GO:0090128)2.98240443
69regulation of dendritic spine morphogenesis (GO:0061001)2.97940258
70vesicle docking involved in exocytosis (GO:0006904)2.96488886
71dendrite morphogenesis (GO:0048813)2.96369328
72regulation of clathrin-mediated endocytosis (GO:2000369)2.95584636
73positive regulation of membrane potential (GO:0045838)2.95508157
74positive regulation of dendritic spine morphogenesis (GO:0061003)2.95271779
75regulation of postsynaptic membrane potential (GO:0060078)2.92949015
76cerebellar Purkinje cell differentiation (GO:0021702)2.92322710
77organelle transport along microtubule (GO:0072384)2.92104693
78neuron-neuron synaptic transmission (GO:0007270)2.90254569
79dendritic spine organization (GO:0097061)2.89831338
80regulation of early endosome to late endosome transport (GO:2000641)2.89415027
81regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.88112730
82neuron cell-cell adhesion (GO:0007158)2.87898628
83G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.87887506
84regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.87516857
85negative regulation of microtubule polymerization (GO:0031115)2.86425292
86regulation of ARF GTPase activity (GO:0032312)2.85869392
87regulation of neurotransmitter transport (GO:0051588)2.84990437
88glutamate receptor signaling pathway (GO:0007215)2.83963363
89positive regulation of dendritic spine development (GO:0060999)2.83335927
90membrane depolarization during action potential (GO:0086010)2.82539231
91regulation of vesicle fusion (GO:0031338)2.81401590
92prepulse inhibition (GO:0060134)2.80392715
93negative regulation of protein oligomerization (GO:0032460)2.80116637
94axon cargo transport (GO:0008088)2.79902813
95cytoskeletal anchoring at plasma membrane (GO:0007016)2.79133488
96alanine transport (GO:0032328)2.78032848
97regulation of exocytosis (GO:0017157)2.76357022
98dopamine receptor signaling pathway (GO:0007212)2.75886779
99regulation of calcium ion-dependent exocytosis (GO:0017158)2.73550886
100positive regulation of neurotransmitter transport (GO:0051590)2.72116911
101auditory behavior (GO:0031223)2.71577765
102response to auditory stimulus (GO:0010996)2.71571809
103signal release (GO:0023061)2.70611736
104innervation (GO:0060384)2.70367390
105positive regulation of protein dephosphorylation (GO:0035307)2.70050195
106positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.69408129
107regulation of synaptic transmission, glutamatergic (GO:0051966)2.69192813
108long-term synaptic potentiation (GO:0060291)2.68632510
109positive regulation of synaptic transmission (GO:0050806)2.68486886
110positive regulation of Rap GTPase activity (GO:0032854)2.68084102
111cellular sodium ion homeostasis (GO:0006883)2.67877932
112regulation of synaptic transmission (GO:0050804)2.67597969
113protein localization to endosome (GO:0036010)2.65333962
114acidic amino acid transport (GO:0015800)2.64625240
115myelin maintenance (GO:0043217)2.64314762
116synaptic vesicle transport (GO:0048489)2.60938795
117establishment of synaptic vesicle localization (GO:0097480)2.60938795
118positive regulation of fibroblast migration (GO:0010763)2.60926387
119positive regulation of exocytosis (GO:0045921)2.60879419
120dicarboxylic acid transport (GO:0006835)2.60545175
121vesicle docking (GO:0048278)2.59099043
122mating behavior (GO:0007617)2.59071987
123response to morphine (GO:0043278)2.57558205
124positive regulation of vesicle fusion (GO:0031340)2.56203823
125chemosensory behavior (GO:0007635)2.53727344
126response to gravity (GO:0009629)2.48920576
127cell communication involved in cardiac conduction (GO:0086065)2.45306529
128regulation of dendritic spine development (GO:0060998)2.43547373
129central nervous system myelination (GO:0022010)2.41805863
130axon ensheathment in central nervous system (GO:0032291)2.41805863
131peptidyl-tyrosine autophosphorylation (GO:0038083)2.38780661
132acid secretion (GO:0046717)2.38394102
133regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.38206310

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.79740205
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.27166635
3RARB_27405468_Chip-Seq_BRAIN_Mouse2.93891720
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.64842515
5REST_21632747_ChIP-Seq_MESCs_Mouse2.64310280
6ERG_21242973_ChIP-ChIP_JURKAT_Human2.48546582
7REST_18959480_ChIP-ChIP_MESCs_Mouse2.45187015
8DROSHA_22980978_ChIP-Seq_HELA_Human2.40766282
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.30109461
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.24422560
11SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.18832510
12ZFP281_18757296_ChIP-ChIP_E14_Mouse2.13848832
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.11285716
14IKZF1_21737484_ChIP-ChIP_HCT116_Human2.10988520
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.09437532
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.06142099
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.06142099
18KDM2B_26808549_Chip-Seq_K562_Human2.05323120
19JARID2_20064375_ChIP-Seq_MESCs_Mouse1.98320536
20LXR_22292898_ChIP-Seq_THP-1_Human1.96378299
21SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88844506
22DNAJC2_21179169_ChIP-ChIP_NT2_Human1.88544747
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85171248
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.82937751
25KDM2B_26808549_Chip-Seq_SUP-B15_Human1.82240575
26RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.81922690
27EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.80941466
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.80071752
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.79794599
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.79055697
31ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.78153932
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.76158253
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.75255175
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75098201
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.72469063
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.71833200
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.68917938
38SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.66615006
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.66252584
40ZFP281_27345836_Chip-Seq_ESCs_Mouse1.57978301
41SRY_22984422_ChIP-ChIP_TESTIS_Rat1.55481849
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54584775
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.54113536
44KDM2B_26808549_Chip-Seq_DND41_Human1.51295362
45* TET1_21490601_ChIP-Seq_MESCs_Mouse1.50032071
46GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.47261833
47TP63_17297297_ChIP-ChIP_HaCaT_Human1.42373273
48CTCF_27219007_Chip-Seq_Bcells_Human1.37675932
49PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.35570295
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34408926
51SMC4_20622854_ChIP-Seq_HELA_Human1.33896200
52ZNF263_19887448_ChIP-Seq_K562_Human1.33784085
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.32050338
54RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.30239169
55CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30193480
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.27955027
57AR_21572438_ChIP-Seq_LNCaP_Human1.26963087
58GBX2_23144817_ChIP-Seq_PC3_Human1.25317291
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.24962354
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24370327
61TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24136887
62WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23511229
63KDM2B_26808549_Chip-Seq_JURKAT_Human1.22817541
64CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22120918
65EED_16625203_ChIP-ChIP_MESCs_Mouse1.21910108
66RING1B_27294783_Chip-Seq_ESCs_Mouse1.20647934
67TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.19368607
68DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16879701
69SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15906287
70RACK7_27058665_Chip-Seq_MCF-7_Human1.14656822
71CREB1_26743006_Chip-Seq_LNCaP_Human1.14377400
72TCF7_22412390_ChIP-Seq_EML_Mouse1.14265825
73* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13755070
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.11604141
75SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10736106
76OCT4_19829295_ChIP-Seq_ESCs_Human1.10202194
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06711747
78P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06660100
79AR_19668381_ChIP-Seq_PC3_Human1.05953560
80KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05444126
81PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04985864
82KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04261589
83KLF4_19829295_ChIP-Seq_ESCs_Human1.02385381
84GATA1_19941827_ChIP-Seq_MEL_Mouse1.01402795
85NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00830186
86TET1_21451524_ChIP-Seq_MESCs_Mouse1.00408294
87OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99852145
88P68_20966046_ChIP-Seq_HELA_Human0.96891925
89GATA2_21666600_ChIP-Seq_HMVEC_Human0.96874765
90ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96721855
91SOX2_21211035_ChIP-Seq_LN229_Gbm0.94267481
92PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.93432206
93SA1_27219007_Chip-Seq_Bcells_Human0.92678169
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91423762
95RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90991542
96TP53_20018659_ChIP-ChIP_R1E_Mouse0.90802910
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90553489
98NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90175847
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89021153
100TP53_23651856_ChIP-Seq_MEFs_Mouse0.88997104
101SMAD4_21741376_ChIP-Seq_ESCs_Human0.88663388
102ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88483531
103GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.88275525
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87990521
105E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.87364157
106BCOR_27268052_Chip-Seq_Bcells_Human0.87215899
107GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.87106451
108CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86764851
109SMC1_22415368_ChIP-Seq_MEFs_Mouse0.86334236
110FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85836159
111RAD21_21589869_ChIP-Seq_MESCs_Mouse0.85562607
112JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.85247007
113ZNF274_21170338_ChIP-Seq_K562_Hela0.84925848
114SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.84629008
115* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84588564
116TP63_22573176_ChIP-Seq_HFKS_Human0.81630682
117SA1_27219007_Chip-Seq_ERYTHROID_Human0.79626151
118ELF1_20517297_ChIP-Seq_JURKAT_Human0.78837552
119ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.78518515
120P53_22127205_ChIP-Seq_FIBROBLAST_Human0.78476077
121MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.78366498
122NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.77959029
123NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.77343555
124MITF_21258399_ChIP-Seq_MELANOMA_Human0.77131500
125SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.76024523
126YAP1_20516196_ChIP-Seq_MESCs_Mouse0.75338992
127SMAD4_21741376_ChIP-Seq_HESCs_Human0.74922595

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.91459234
2MP0003635_abnormal_synaptic_transmissio4.00569247
3MP0004270_analgesia3.77032647
4MP0002063_abnormal_learning/memory/cond3.25694683
5MP0003880_abnormal_central_pattern3.05082791
6MP0009046_muscle_twitch3.01422114
7MP0009745_abnormal_behavioral_response2.97968475
8MP0002064_seizures2.97201340
9MP0002822_catalepsy2.97126633
10MP0001968_abnormal_touch/_nociception2.92417387
11MP0002572_abnormal_emotion/affect_behav2.71367945
12MP0002734_abnormal_mechanical_nocicepti2.60722373
13MP0004858_abnormal_nervous_system2.58478370
14MP0002733_abnormal_thermal_nociception2.57408584
15MP0002909_abnormal_adrenal_gland2.53098297
16MP0003329_amyloid_beta_deposits2.43076398
17MP0001970_abnormal_pain_threshold2.40634850
18MP0002735_abnormal_chemical_nociception2.39593476
19MP0009780_abnormal_chondrocyte_physiolo2.32056412
20MP0003283_abnormal_digestive_organ2.29221812
21MP0002272_abnormal_nervous_system2.22707310
22MP0005423_abnormal_somatic_nervous2.12201209
23MP0002736_abnormal_nociception_after2.09562909
24MP0004811_abnormal_neuron_physiology2.09429194
25MP0001501_abnormal_sleep_pattern1.94586138
26MP0000920_abnormal_myelination1.92572475
27MP0004233_abnormal_muscle_weight1.89991473
28MP0008569_lethality_at_weaning1.87896367
29MP0001440_abnormal_grooming_behavior1.87738489
30MP0001486_abnormal_startle_reflex1.73768453
31MP0000955_abnormal_spinal_cord1.73277388
32MP0002184_abnormal_innervation1.64996471
33MP0003172_abnormal_lysosome_physiology1.63517652
34MP0000013_abnormal_adipose_tissue1.62832857
35MP0002067_abnormal_sensory_capabilities1.61223398
36MP0003879_abnormal_hair_cell1.59712340
37MP0003633_abnormal_nervous_system1.59226764
38MP0005386_behavior/neurological_phenoty1.57022502
39MP0004924_abnormal_behavior1.57022502
40MP0005646_abnormal_pituitary_gland1.49210179
41MP0010386_abnormal_urinary_bladder1.43046596
42MP0008961_abnormal_basal_metabolism1.41544061
43MP0002557_abnormal_social/conspecific_i1.40310390
44MP0002066_abnormal_motor_capabilities/c1.39065246
45MP0003075_altered_response_to1.37746047
46MP0002882_abnormal_neuron_morphology1.29279202
47MP0000604_amyloidosis1.27344644
48MP0005645_abnormal_hypothalamus_physiol1.24970197
49MP0003191_abnormal_cellular_cholesterol1.24963847
50MP0004885_abnormal_endolymph1.23960879
51MP0005166_decreased_susceptibility_to1.23839195
52MP0003631_nervous_system_phenotype1.22854762
53MP0000778_abnormal_nervous_system1.22517019
54MP0008260_abnormal_autophagy1.21567568
55MP0000751_myopathy1.20308398
56MP0003183_abnormal_peptide_metabolism1.19229287
57MP0008874_decreased_physiological_sensi1.14153669
58MP0003045_fibrosis1.13576551
59MP0001502_abnormal_circadian_rhythm1.12978332
60MP0002653_abnormal_ependyma_morphology1.11324137
61MP0003123_paternal_imprinting1.10884348
62MP0006276_abnormal_autonomic_nervous1.04114207
63MP0001958_emphysema0.99515243
64MP0003634_abnormal_glial_cell0.98739946
65MP0004130_abnormal_muscle_cell0.95917318
66MP0005167_abnormal_blood-brain_barrier0.94448814
67MP0002152_abnormal_brain_morphology0.93936205
68MP0008872_abnormal_physiological_respon0.92865287
69MP0005623_abnormal_meninges_morphology0.90464836
70MP0001348_abnormal_lacrimal_gland0.89582642
71MP0004142_abnormal_muscle_tone0.89203575
72MP0009840_abnormal_foam_cell0.88619489
73MP0002069_abnormal_eating/drinking_beha0.87192962
74MP0002229_neurodegeneration0.86508805
75MP0000681_abnormal_thyroid_gland0.85965989
76MP0004145_abnormal_muscle_electrophysio0.85258502
77MP0005058_abnormal_lysosome_morphology0.84812207
78MP0003279_aneurysm0.84765935
79MP0010234_abnormal_vibrissa_follicle0.84535847
80MP0005535_abnormal_body_temperature0.83801972
81MP0002269_muscular_atrophy0.83790783
82MP0003787_abnormal_imprinting0.83145894
83MP0005165_increased_susceptibility_to0.82473378
84MP0000639_abnormal_adrenal_gland0.81202155
85MP0001765_abnormal_ion_homeostasis0.80651498
86MP0003122_maternal_imprinting0.75831176
87MP0002295_abnormal_pulmonary_circulatio0.74646273
88MP0000569_abnormal_digit_pigmentation0.74424249
89MP0001177_atelectasis0.74115758
90MP0000747_muscle_weakness0.74110009
91MP0006082_CNS_inflammation0.73757244
92MP0003436_decreased_susceptibility_to0.73116936
93MP0003632_abnormal_nervous_system0.71994717
94MP0005409_darkened_coat_color0.70312520
95MP0006072_abnormal_retinal_apoptosis0.70076971
96MP0003690_abnormal_glial_cell0.68528504
97MP0000678_abnormal_parathyroid_gland0.67232577
98MP0003300_gastrointestinal_ulcer0.66376185
99MP0001905_abnormal_dopamine_level0.62640185
100MP0000003_abnormal_adipose_tissue0.62477238
101MP0003137_abnormal_impulse_conducting0.61945215
102MP0002876_abnormal_thyroid_physiology0.61355485
103MP0003091_abnormal_cell_migration0.59789588
104MP0004085_abnormal_heartbeat0.58093916
105MP0002089_abnormal_postnatal_growth/wei0.57811188
106MP0003303_peritoneal_inflammation0.57798370
107MP0001533_abnormal_skeleton_physiology0.57503773
108MP0002090_abnormal_vision0.56944051
109MP0001963_abnormal_hearing_physiology0.56358064
110MP0009278_abnormal_bone_marrow0.56179978
111MP0005171_absent_coat_pigmentation0.56156993
112MP0004510_myositis0.55339894
113MP0002837_dystrophic_cardiac_calcinosis0.55130620
114MP0003453_abnormal_keratinocyte_physiol0.54574404
115MP0003956_abnormal_body_size0.54440426
116MP0003953_abnormal_hormone_level0.54317638
117MP0010769_abnormal_survival0.53793259
118MP0008438_abnormal_cutaneous_collagen0.53486495
119MP0001346_abnormal_lacrimal_gland0.53028178
120MP0001984_abnormal_olfaction0.52815285
121MP0002078_abnormal_glucose_homeostasis0.51803823
122MP0001943_abnormal_respiration0.51420901
123MP0004947_skin_inflammation0.51102186
124MP0010768_mortality/aging0.50992063
125MP0003705_abnormal_hypodermis_morpholog0.50377261
126MP0003566_abnormal_cell_adhesion0.50074517
127MP0000579_abnormal_nail_morphology0.49929451
128MP0004742_abnormal_vestibular_system0.49034109
129MP0001849_ear_inflammation0.48999557

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.95532722
2Focal motor seizures (HP:0011153)4.94888580
3Visual hallucinations (HP:0002367)4.94566182
4Focal seizures (HP:0007359)4.30341383
5Annular pancreas (HP:0001734)3.95749805
6Abnormality of the lower motor neuron (HP:0002366)3.89140976
7Action tremor (HP:0002345)3.83261586
8Atonic seizures (HP:0010819)3.75850967
9Supranuclear gaze palsy (HP:0000605)3.64985005
10Ankle clonus (HP:0011448)3.51593651
11Epileptic encephalopathy (HP:0200134)3.44218197
12Absence seizures (HP:0002121)3.24501405
13Papilledema (HP:0001085)3.23297408
14Febrile seizures (HP:0002373)3.21078311
15Depression (HP:0000716)3.10174444
16Progressive cerebellar ataxia (HP:0002073)3.09719374
17Hypercortisolism (HP:0001578)3.02865913
18Tetraplegia (HP:0002445)2.98920152
19Generalized tonic-clonic seizures (HP:0002069)2.95397805
20Mutism (HP:0002300)2.92681621
21Dialeptic seizures (HP:0011146)2.81557182
22Turricephaly (HP:0000262)2.79634972
23Pheochromocytoma (HP:0002666)2.76992800
24Torticollis (HP:0000473)2.74999447
25Dysdiadochokinesis (HP:0002075)2.72299075
26Postural instability (HP:0002172)2.71525233
27Impaired vibration sensation in the lower limbs (HP:0002166)2.67422094
28Rigidity (HP:0002063)2.65275829
29Delusions (HP:0000746)2.61309453
30Abnormal eating behavior (HP:0100738)2.59773401
31Urinary bladder sphincter dysfunction (HP:0002839)2.54829833
32Ventricular fibrillation (HP:0001663)2.54146948
33Dysmetria (HP:0001310)2.52118253
34Impaired social interactions (HP:0000735)2.50786128
35Abnormal social behavior (HP:0012433)2.50786128
36Poor eye contact (HP:0000817)2.50062289
37Diminished motivation (HP:0000745)2.47301170
38Focal dystonia (HP:0004373)2.45202574
39Anxiety (HP:0000739)2.43670336
40Dysostosis multiplex (HP:0000943)2.42953124
41Hemiplegia (HP:0002301)2.41401500
42Mucopolysacchariduria (HP:0008155)2.38501691
43Urinary glycosaminoglycan excretion (HP:0003541)2.38501691
44Cerebral hypomyelination (HP:0006808)2.37545982
45Cerebral inclusion bodies (HP:0100314)2.34677756
46Urinary urgency (HP:0000012)2.33990062
47Intention tremor (HP:0002080)2.30759510
48Dysmetric saccades (HP:0000641)2.28955908
49Obstructive sleep apnea (HP:0002870)2.27027727
50Craniofacial dystonia (HP:0012179)2.26291513
51Bundle branch block (HP:0011710)2.26190896
52Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.26181936
53Growth hormone excess (HP:0000845)2.26139517
54Truncal ataxia (HP:0002078)2.25300558
55Insomnia (HP:0100785)2.24753975
56Abnormality of liposaccharide metabolism (HP:0010968)2.24721011
57Abnormality of glycosphingolipid metabolism (HP:0004343)2.24721011
58Abnormality of glycolipid metabolism (HP:0010969)2.24721011
59Abnormality of mucopolysaccharide metabolism (HP:0011020)2.24712085
60Abnormality of polysaccharide metabolism (HP:0011012)2.24712085
61Abnormality of glycosaminoglycan metabolism (HP:0004371)2.24712085
62Agitation (HP:0000713)2.24378570
63Neuroendocrine neoplasm (HP:0100634)2.23941299
64Hyperparathyroidism (HP:0000843)2.23845737
65Clonus (HP:0002169)2.23722093
66Megalencephaly (HP:0001355)2.23708395
67Impaired smooth pursuit (HP:0007772)2.23650927
68Resting tremor (HP:0002322)2.23226645
69Bradykinesia (HP:0002067)2.22352631
70Status epilepticus (HP:0002133)2.21360333
71Neoplasm of the peripheral nervous system (HP:0100007)2.20526474
72Pointed chin (HP:0000307)2.18571768
73Rapidly progressive (HP:0003678)2.17817410
74EEG with generalized epileptiform discharges (HP:0011198)2.17699994
75Hypsarrhythmia (HP:0002521)2.17294159
76Peripheral hypomyelination (HP:0007182)2.16805265
77Neurofibrillary tangles (HP:0002185)2.16563434
78Slow saccadic eye movements (HP:0000514)2.15017442
79Termporal pattern (HP:0011008)2.14918490
80Insidious onset (HP:0003587)2.14918490
81Failure to thrive in infancy (HP:0001531)2.14640854
82Epileptiform EEG discharges (HP:0011182)2.14574247
83Distal upper limb amyotrophy (HP:0007149)2.14444346
84Upper limb amyotrophy (HP:0009129)2.14444346
85Neuronal loss in central nervous system (HP:0002529)2.12128594
86Dementia (HP:0000726)2.11848692
87Spastic gait (HP:0002064)2.09427473
88Genetic anticipation (HP:0003743)2.07173572
89Axonal loss (HP:0003447)2.05013282
90Cerebral aneurysm (HP:0004944)2.04648103
91Fetal akinesia sequence (HP:0001989)2.02397758
92Scanning speech (HP:0002168)2.01386957
93Amblyopia (HP:0000646)2.00117602
94Hypokinesia (HP:0002375)1.99681886
95Abnormality of the periventricular white matter (HP:0002518)1.98474026
96Abnormal atrioventricular conduction (HP:0005150)1.98244336
97Hand muscle atrophy (HP:0009130)1.96855946
98Lower limb amyotrophy (HP:0007210)1.95364947
99Limb dystonia (HP:0002451)1.93832902
100Nuclear cataract (HP:0100018)1.93204282
101Loss of speech (HP:0002371)1.92838020
102Gaze-evoked nystagmus (HP:0000640)1.92310855
103Abnormality of saccadic eye movements (HP:0000570)1.92089579
104Diminished movement (HP:0002374)1.92073703
105Male infertility (HP:0003251)1.91674861
106Achilles tendon contracture (HP:0001771)1.91077867
107Stridor (HP:0010307)1.89468232
108Heart block (HP:0012722)1.89253355
109Abnormality of ocular smooth pursuit (HP:0000617)1.88507900
110Abnormal gallbladder physiology (HP:0012438)1.87853079
111Cholecystitis (HP:0001082)1.87853079
112Apathy (HP:0000741)1.87747606
113Increased cerebral lipofuscin (HP:0011813)1.87742741
114Spinal canal stenosis (HP:0003416)1.87250009
115Dysautonomia (HP:0002459)1.85686637
116Abnormality of pain sensation (HP:0010832)1.85224659
117Impaired pain sensation (HP:0007328)1.85224659
118Lower limb muscle weakness (HP:0007340)1.83842161
119Abnormality of binocular vision (HP:0011514)1.83391143
120Diplopia (HP:0000651)1.83391143
121Increased circulating renin level (HP:0000848)1.82847781
122Stereotypic behavior (HP:0000733)1.82335863
123Sleep apnea (HP:0010535)1.82213856
124Impaired vibratory sensation (HP:0002495)1.81880835
125Akinesia (HP:0002304)1.81411148
126Hypoventilation (HP:0002791)1.81364914
127Distal lower limb muscle weakness (HP:0009053)1.80685588
128Postural tremor (HP:0002174)1.80535185
129Abnormal EKG (HP:0003115)1.80419998
130Lower limb asymmetry (HP:0100559)1.80135962
131Broad-based gait (HP:0002136)1.78368216
132Hemiparesis (HP:0001269)1.77452855
133Amyotrophic lateral sclerosis (HP:0007354)1.76568465
134Atrioventricular block (HP:0001678)1.75418531
135Interstitial pulmonary disease (HP:0006530)1.74367275

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.28343055
2NTRK33.35363860
3EPHA42.65921229
4KSR22.62667786
5PRKD32.41349452
6NTRK12.40541541
7DAPK22.37940931
8MARK12.26685378
9MINK12.25955869
10PAK62.25652627
11DAPK12.21180732
12TESK12.18801821
13LATS22.17044899
14ICK2.13325171
15TYRO32.09772613
16DDR22.08166595
17MAP3K42.05356173
18PINK11.86744942
19CAMKK11.86363447
20TAOK11.79575935
21MAP3K61.67080652
22UHMK11.66059400
23NTRK21.64395706
24ERN11.62780424
25TRIB31.62417818
26STK381.57085237
27PHKG21.47558310
28PHKG11.47558310
29MAPK151.38136966
30MAP3K21.36179355
31CDK51.35608660
32MAP2K41.35154551
33ARAF1.34747354
34RIPK11.31230415
35PDGFRA1.28380290
36GRK51.23066988
37MAP3K111.22621430
38MATK1.20813337
39LMTK21.20589517
40SMG11.18594222
41MAP2K71.18171860
42BMX1.16884012
43ALK1.14983265
44RET1.13356571
45TAOK21.10739814
46NEK11.08788271
47MAP3K121.07353338
48FGR1.05741115
49KSR11.05089550
50PRKCH1.04524272
51MAPK121.03034550
52SCYL21.01739656
53PRKD21.00806027
54NEK60.99880962
55BMPR20.99771877
56SIK20.96599858
57CDC42BPA0.95181206
58PRPF4B0.94593089
59RAF10.88415482
60IRAK30.88219492
61MAP3K10.87548821
62CAMKK20.86968662
63MAP3K130.84638540
64RIPK40.84516863
65CDK150.82914852
66EPHB10.82458931
67PRKCG0.82457666
68PRKG20.81698789
69CDK180.80466310
70CDK140.79994129
71MARK20.77825581
72MAP3K30.75414612
73SIK10.75153591
74FES0.74819361
75CDK11A0.71150868
76JAK10.70165099
77PAK30.68968288
78PLK20.68142443
79CDK190.67675186
80STK110.67053354
81CAMK2A0.63784893
82MOS0.61096972
83PDK10.60410804
84SGK30.59870206
85PDPK10.59381249
86ROCK20.59156204
87MAP2K10.57781829
88TNK20.57390237
89FER0.55311285
90BRSK10.54946798
91IRAK20.53459770
92PTK20.53411988
93HIPK20.51149825
94PKN20.50967961
95MAPKAPK30.50033303
96PRKCZ0.49843143
97CAMK2B0.48410771
98RPS6KA20.47446010
99MAP2K60.47267357
100SGK10.47228271
101PTK2B0.47097508
102CAMK10.47091624
103MAPK130.47008250
104RPS6KA30.45975513
105DMPK0.45785113
106DAPK30.45425548
107TBK10.43947268
108MAPK100.43548542
109PRKAA10.42881606
110SGK2230.40532210
111SGK4940.40532210
112CAMK2G0.40084422
113SGK20.39271659
114EPHA20.36969028
115DYRK1A0.36659240
116PRKD10.36321844
117AKT30.36137362
118CAMK40.35776601
119MAP2K30.35589258
120CSNK1G20.35437981
121BRAF0.35385244
122CAMK2D0.33449859
123FYN0.32488320
124DYRK1B0.31539690
125LIMK10.26586660
126JAK20.25615401

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.31751292
2Olfactory transduction_Homo sapiens_hsa047402.50278453
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.47743696
4Nicotine addiction_Homo sapiens_hsa050332.35418724
5GABAergic synapse_Homo sapiens_hsa047272.27494466
6Long-term potentiation_Homo sapiens_hsa047202.24895287
7Circadian entrainment_Homo sapiens_hsa047132.17096512
8Amphetamine addiction_Homo sapiens_hsa050312.05862357
9Insulin secretion_Homo sapiens_hsa049112.03958204
10Glutamatergic synapse_Homo sapiens_hsa047241.93995686
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.91440159
12Morphine addiction_Homo sapiens_hsa050321.90582141
13Dopaminergic synapse_Homo sapiens_hsa047281.90540772
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.83189372
15Salivary secretion_Homo sapiens_hsa049701.80017802
16Gastric acid secretion_Homo sapiens_hsa049711.72437544
17Cholinergic synapse_Homo sapiens_hsa047251.70869304
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.70104679
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.57656629
20GnRH signaling pathway_Homo sapiens_hsa049121.56943086
21Nitrogen metabolism_Homo sapiens_hsa009101.56207471
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.54938771
23Gap junction_Homo sapiens_hsa045401.50929357
24Vitamin B6 metabolism_Homo sapiens_hsa007501.48294757
25Long-term depression_Homo sapiens_hsa047301.44823685
26Cocaine addiction_Homo sapiens_hsa050301.43517254
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42567738
28Oxytocin signaling pathway_Homo sapiens_hsa049211.42387658
29Estrogen signaling pathway_Homo sapiens_hsa049151.39651837
30Fatty acid biosynthesis_Homo sapiens_hsa000611.36314351
31Renin secretion_Homo sapiens_hsa049241.34329855
32mTOR signaling pathway_Homo sapiens_hsa041501.34212275
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30342913
34Type II diabetes mellitus_Homo sapiens_hsa049301.29832336
35Taste transduction_Homo sapiens_hsa047421.28249338
36Glioma_Homo sapiens_hsa052141.26284458
37Dorso-ventral axis formation_Homo sapiens_hsa043201.11407987
38ErbB signaling pathway_Homo sapiens_hsa040121.09947166
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09129603
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08855365
41Serotonergic synapse_Homo sapiens_hsa047261.08262254
42VEGF signaling pathway_Homo sapiens_hsa043701.07845515
43Calcium signaling pathway_Homo sapiens_hsa040201.07080010
44Collecting duct acid secretion_Homo sapiens_hsa049661.07009013
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.03903315
46cAMP signaling pathway_Homo sapiens_hsa040241.03601327
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01349560
48Oocyte meiosis_Homo sapiens_hsa041141.00700889
49Glycosaminoglycan degradation_Homo sapiens_hsa005310.94325762
50Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93454631
51Neurotrophin signaling pathway_Homo sapiens_hsa047220.90237995
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88872797
53Melanogenesis_Homo sapiens_hsa049160.88426506
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.87514711
55Circadian rhythm_Homo sapiens_hsa047100.86276384
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84932504
57Choline metabolism in cancer_Homo sapiens_hsa052310.84642563
58Thyroid hormone synthesis_Homo sapiens_hsa049180.83976507
59Vibrio cholerae infection_Homo sapiens_hsa051100.83286375
60Endocytosis_Homo sapiens_hsa041440.83192979
61Insulin signaling pathway_Homo sapiens_hsa049100.83003192
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81846675
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81308529
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80100497
65Arginine biosynthesis_Homo sapiens_hsa002200.78038783
66Endometrial cancer_Homo sapiens_hsa052130.77450160
67Pancreatic secretion_Homo sapiens_hsa049720.76118877
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.76048290
69Bile secretion_Homo sapiens_hsa049760.75510804
70MAPK signaling pathway_Homo sapiens_hsa040100.74763640
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74608082
72Glucagon signaling pathway_Homo sapiens_hsa049220.73184876
73Other glycan degradation_Homo sapiens_hsa005110.71852506
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69575110
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68622527
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67633676
77Prion diseases_Homo sapiens_hsa050200.67144848
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64939790
79Axon guidance_Homo sapiens_hsa043600.64622313
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63886538
81Non-small cell lung cancer_Homo sapiens_hsa052230.60183362
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.59992643
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.57582173
84Rap1 signaling pathway_Homo sapiens_hsa040150.56618110
85Dilated cardiomyopathy_Homo sapiens_hsa054140.55982990
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55905497
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55523434
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55083059
89Colorectal cancer_Homo sapiens_hsa052100.53291937
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52686988
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52508929
92Bladder cancer_Homo sapiens_hsa052190.51790497
93Prolactin signaling pathway_Homo sapiens_hsa049170.51623909
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49642465
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49479133
96Mineral absorption_Homo sapiens_hsa049780.49294694
97Ras signaling pathway_Homo sapiens_hsa040140.49200862
98Osteoclast differentiation_Homo sapiens_hsa043800.47764199
99Amoebiasis_Homo sapiens_hsa051460.46022370
100Renal cell carcinoma_Homo sapiens_hsa052110.44687059
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44418619
102Tuberculosis_Homo sapiens_hsa051520.44132208
103Inositol phosphate metabolism_Homo sapiens_hsa005620.43704310
104Phagosome_Homo sapiens_hsa041450.42658746
105Type I diabetes mellitus_Homo sapiens_hsa049400.42335017
106Salmonella infection_Homo sapiens_hsa051320.42312378
107Hippo signaling pathway_Homo sapiens_hsa043900.42087088
108AMPK signaling pathway_Homo sapiens_hsa041520.41539782
109Lysosome_Homo sapiens_hsa041420.41529485
110HIF-1 signaling pathway_Homo sapiens_hsa040660.41316142
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41255491
112Fructose and mannose metabolism_Homo sapiens_hsa000510.39922604
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.38099620
114Wnt signaling pathway_Homo sapiens_hsa043100.37376813
115Chemokine signaling pathway_Homo sapiens_hsa040620.37105513
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36289637
117Histidine metabolism_Homo sapiens_hsa003400.35937004
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.35263336
119Phenylalanine metabolism_Homo sapiens_hsa003600.32753208

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