SPRYD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine metabolic process (GO:0006558)5.46279398
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.46279398
3L-phenylalanine catabolic process (GO:0006559)5.39242669
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.39242669
5glycine metabolic process (GO:0006544)4.95125112
6aromatic amino acid family catabolic process (GO:0009074)4.80070624
7behavioral response to nicotine (GO:0035095)4.73738722
8drug catabolic process (GO:0042737)4.65345235
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.60426016
10glyoxylate metabolic process (GO:0046487)4.59747782
11fucose catabolic process (GO:0019317)4.44869939
12L-fucose metabolic process (GO:0042354)4.44869939
13L-fucose catabolic process (GO:0042355)4.44869939
14serine family amino acid catabolic process (GO:0009071)4.42690829
15serine family amino acid biosynthetic process (GO:0009070)4.40788637
16cysteine metabolic process (GO:0006534)4.40553479
17kynurenine metabolic process (GO:0070189)4.40292434
18exogenous drug catabolic process (GO:0042738)4.38529840
19water-soluble vitamin biosynthetic process (GO:0042364)4.32968491
20oxidative demethylation (GO:0070989)4.32550438
21indole-containing compound catabolic process (GO:0042436)4.31601285
22indolalkylamine catabolic process (GO:0046218)4.31601285
23tryptophan catabolic process (GO:0006569)4.31601285
24ketone body metabolic process (GO:1902224)4.27122118
25lysine catabolic process (GO:0006554)4.22696221
26lysine metabolic process (GO:0006553)4.22696221
27negative regulation of fibrinolysis (GO:0051918)4.21668895
28bile acid biosynthetic process (GO:0006699)4.17105095
29serine family amino acid metabolic process (GO:0009069)4.16891492
30regulation of triglyceride catabolic process (GO:0010896)4.10276978
31sulfur amino acid catabolic process (GO:0000098)4.09018283
32tryptophan metabolic process (GO:0006568)4.06003083
33urea cycle (GO:0000050)4.00029068
34urea metabolic process (GO:0019627)4.00029068
35alpha-linolenic acid metabolic process (GO:0036109)3.94953722
36regulation of fibrinolysis (GO:0051917)3.91004603
37DNA deamination (GO:0045006)3.89418150
38folic acid metabolic process (GO:0046655)3.87751414
39high-density lipoprotein particle remodeling (GO:0034375)3.87726226
40amino-acid betaine metabolic process (GO:0006577)3.85508023
41respiratory chain complex IV assembly (GO:0008535)3.78834896
42regulation of protein activation cascade (GO:2000257)3.76733450
43alpha-amino acid catabolic process (GO:1901606)3.71887758
44mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.71086935
45mitochondrial respiratory chain complex I assembly (GO:0032981)3.71086935
46NADH dehydrogenase complex assembly (GO:0010257)3.71086935
47fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.69679228
48protein carboxylation (GO:0018214)3.67487647
49peptidyl-glutamic acid carboxylation (GO:0017187)3.67487647
50aromatic amino acid family metabolic process (GO:0009072)3.67480534
51protein complex biogenesis (GO:0070271)3.67211442
52nitrogen cycle metabolic process (GO:0071941)3.67192282
53aldehyde catabolic process (GO:0046185)3.66565958
54homocysteine metabolic process (GO:0050667)3.61247183
55L-serine metabolic process (GO:0006563)3.60151134
56imidazole-containing compound metabolic process (GO:0052803)3.59205982
57regulation of nuclear cell cycle DNA replication (GO:0033262)3.57749341
58mitochondrial respiratory chain complex assembly (GO:0033108)3.49250975
59regulation of complement activation (GO:0030449)3.48417881
60bile acid metabolic process (GO:0008206)3.47716401
61regulation of cholesterol esterification (GO:0010872)3.44533293
62complement activation, alternative pathway (GO:0006957)3.42877321
63cellular amino acid catabolic process (GO:0009063)3.42457007
64folic acid-containing compound biosynthetic process (GO:0009396)3.42322636
65preassembly of GPI anchor in ER membrane (GO:0016254)3.36852499
66cytochrome complex assembly (GO:0017004)3.36354748
67plasma lipoprotein particle remodeling (GO:0034369)3.35423033
68protein-lipid complex remodeling (GO:0034368)3.35423033
69macromolecular complex remodeling (GO:0034367)3.35423033
70negative regulation of cholesterol transport (GO:0032375)3.35334866
71negative regulation of sterol transport (GO:0032372)3.35334866
72ethanol oxidation (GO:0006069)3.33377882
73response to pheromone (GO:0019236)3.32881518
74reverse cholesterol transport (GO:0043691)3.32242578
75tyrosine metabolic process (GO:0006570)3.31763099
76triglyceride homeostasis (GO:0070328)3.29894529
77acylglycerol homeostasis (GO:0055090)3.29894529
78sulfur amino acid biosynthetic process (GO:0000097)3.28038651
79tetrahydrofolate metabolic process (GO:0046653)3.27086428
80one-carbon metabolic process (GO:0006730)3.26206081
81alkaloid metabolic process (GO:0009820)3.23556679
82cellular ketone body metabolic process (GO:0046950)3.23186470
83valine metabolic process (GO:0006573)3.21605236
842-oxoglutarate metabolic process (GO:0006103)3.19761272
85L-methionine salvage (GO:0071267)3.17324548
86L-methionine biosynthetic process (GO:0071265)3.17324548
87amino acid salvage (GO:0043102)3.17324548
88coenzyme catabolic process (GO:0009109)3.16936859
89rRNA modification (GO:0000154)3.16870251
90nucleobase biosynthetic process (GO:0046112)3.14098340
91aspartate family amino acid catabolic process (GO:0009068)3.13025645
92heme transport (GO:0015886)3.10099864
93detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.09309634
94plasma lipoprotein particle clearance (GO:0034381)3.07360030
95blood coagulation, intrinsic pathway (GO:0007597)3.07107751
96pteridine-containing compound biosynthetic process (GO:0042559)3.07040381
97folic acid-containing compound metabolic process (GO:0006760)3.05802856
98phospholipid efflux (GO:0033700)3.05569297
99ubiquinone biosynthetic process (GO:0006744)3.05479959
100negative regulation of telomere maintenance (GO:0032205)3.05430732
101organic acid catabolic process (GO:0016054)3.05349246
102carboxylic acid catabolic process (GO:0046395)3.05349246
103branched-chain amino acid catabolic process (GO:0009083)3.04566197
104acetyl-CoA metabolic process (GO:0006084)3.04235399
105purine nucleobase biosynthetic process (GO:0009113)3.04120531
106bile acid and bile salt transport (GO:0015721)3.03429431
107cellular modified amino acid catabolic process (GO:0042219)3.02962474
108sulfur amino acid metabolic process (GO:0000096)3.00903598
109negative regulation of fatty acid biosynthetic process (GO:0045717)3.00596089
110methionine biosynthetic process (GO:0009086)3.00496089
111arginine metabolic process (GO:0006525)3.00327868
112cofactor catabolic process (GO:0051187)2.98296743
113indole-containing compound metabolic process (GO:0042430)2.97893525
114sulfation (GO:0051923)2.97607230
115glutamate metabolic process (GO:0006536)2.96824698
116aspartate family amino acid metabolic process (GO:0009066)2.96086313
117detection of light stimulus involved in sensory perception (GO:0050962)2.95760297
118detection of light stimulus involved in visual perception (GO:0050908)2.95760297
119L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.94538015
120replication fork processing (GO:0031297)2.94487366
121indolalkylamine metabolic process (GO:0006586)2.94483346
122regulation of translation, ncRNA-mediated (GO:0045974)2.94390759
123negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.94390759
124negative regulation of translation, ncRNA-mediated (GO:0040033)2.94390759
125benzene-containing compound metabolic process (GO:0042537)2.93640040
126plasma lipoprotein particle assembly (GO:0034377)2.92335521
127cellular biogenic amine catabolic process (GO:0042402)2.90871054
128amine catabolic process (GO:0009310)2.90871054
129carnitine metabolic process (GO:0009437)2.89272870
130NAD biosynthetic process (GO:0009435)2.89091529
131pseudouridine synthesis (GO:0001522)2.88387355
132pteridine-containing compound metabolic process (GO:0042558)2.88243656
133cellular glucuronidation (GO:0052695)2.88076468
134reciprocal DNA recombination (GO:0035825)2.87425239
135reciprocal meiotic recombination (GO:0007131)2.87425239
136positive regulation of lipoprotein lipase activity (GO:0051006)2.86543207
137positive regulation of triglyceride lipase activity (GO:0061365)2.86543207
138ubiquinone metabolic process (GO:0006743)2.85665247
139S-adenosylmethionine metabolic process (GO:0046500)2.85395877
140omega-hydroxylase P450 pathway (GO:0097267)2.85095391
141mannosylation (GO:0097502)2.76089650
142negative regulation of DNA-dependent DNA replication (GO:2000104)2.74664583
143peptidyl-histidine modification (GO:0018202)2.73810455
144protein-cofactor linkage (GO:0018065)2.73573057
145epoxygenase P450 pathway (GO:0019373)2.73156638
146platelet dense granule organization (GO:0060155)2.71164477
147quinone biosynthetic process (GO:1901663)2.69148738
148prenylation (GO:0097354)2.67229855
149protein prenylation (GO:0018342)2.67229855
150regulation of hexokinase activity (GO:1903299)2.66045346
151regulation of glucokinase activity (GO:0033131)2.66045346
152cellular response to ATP (GO:0071318)2.62585463
153purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.59863122
1543-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.59863122
155drug metabolic process (GO:0017144)2.59075894
156double-strand break repair via homologous recombination (GO:0000724)2.58814827
157recombinational repair (GO:0000725)2.58691581
158tRNA modification (GO:0006400)2.58491174
159protein import into peroxisome matrix (GO:0016558)2.57934975
160positive regulation of fatty acid transport (GO:2000193)2.57703005
161methionine metabolic process (GO:0006555)2.55806989
162mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.54770316
163flavonoid metabolic process (GO:0009812)2.52548213
164rRNA catabolic process (GO:0016075)2.49740745
165basic amino acid transport (GO:0015802)2.49018622
166tRNA processing (GO:0008033)2.48738859
167negative regulation of reactive oxygen species metabolic process (GO:2000378)2.48723888
168energy coupled proton transport, down electrochemical gradient (GO:0015985)2.48596512
169ATP synthesis coupled proton transport (GO:0015986)2.48596512

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.19093542
2ZNF274_21170338_ChIP-Seq_K562_Hela4.40520327
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.06419428
4E2F7_22180533_ChIP-Seq_HELA_Human3.80210260
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.74655606
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.53131580
7VDR_22108803_ChIP-Seq_LS180_Human3.50793493
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.42301860
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.41884839
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.40823739
11EGR1_23403033_ChIP-Seq_LIVER_Mouse3.40110995
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.90800643
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.89076502
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.77401781
15* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.66948642
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.64302769
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.49018964
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.42822777
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.40747958
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.40614601
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.37294393
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.33747144
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.31891669
24* NOTCH1_21737748_ChIP-Seq_TLL_Human2.28288693
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.26215266
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.24173874
27* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.21697829
28EWS_26573619_Chip-Seq_HEK293_Human2.17600519
29IRF1_19129219_ChIP-ChIP_H3396_Human2.16404581
30GBX2_23144817_ChIP-Seq_PC3_Human2.13088492
31ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06705063
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.01347228
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.99507277
34IGF1R_20145208_ChIP-Seq_DFB_Human1.99338470
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.97988330
36FUS_26573619_Chip-Seq_HEK293_Human1.92674396
37* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91310945
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90287571
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.86001970
40ER_23166858_ChIP-Seq_MCF-7_Human1.85055394
41HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.84820499
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84034536
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81095455
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80830709
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.79338239
46TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78812946
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.76436449
48* MYC_18940864_ChIP-ChIP_HL60_Human1.76088733
49DCP1A_22483619_ChIP-Seq_HELA_Human1.74338826
50RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74280483
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.73688618
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.71782881
53TAF15_26573619_Chip-Seq_HEK293_Human1.70582519
54STAT3_1855785_ChIP-Seq_MESCs_Mouse1.67997061
55XRN2_22483619_ChIP-Seq_HELA_Human1.67578987
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67098975
57TP53_22573176_ChIP-Seq_HFKS_Human1.66168362
58E2F4_17652178_ChIP-ChIP_JURKAT_Human1.65015652
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.63133117
60FOXP3_21729870_ChIP-Seq_TREG_Human1.61719892
61* VDR_23849224_ChIP-Seq_CD4+_Human1.60440127
62GABP_19822575_ChIP-Seq_HepG2_Human1.59557243
63P300_19829295_ChIP-Seq_ESCs_Human1.52940473
64FOXM1_23109430_ChIP-Seq_U2OS_Human1.52512922
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52321680
66AR_21909140_ChIP-Seq_LNCAP_Human1.50480968
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47642150
68* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45471160
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.44997502
70FOXA1_25329375_ChIP-Seq_VCAP_Human1.42017522
71FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42017522
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40236127
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39376761
74NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.38563044
75ERA_21632823_ChIP-Seq_H3396_Human1.37492434
76ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37473383
77THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37221484
78* GATA3_21878914_ChIP-Seq_MCF-7_Human1.36771328
79AR_20517297_ChIP-Seq_VCAP_Human1.36658422
80MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36609124
81BCAT_22108803_ChIP-Seq_LS180_Human1.36230229
82GATA1_22025678_ChIP-Seq_K562_Human1.35510567
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35301166
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34780069
85NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32654397
86CBP_20019798_ChIP-Seq_JUKART_Human1.30611899
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30611899
88NCOR_22424771_ChIP-Seq_293T_Human1.30598512
89ETV2_25802403_ChIP-Seq_MESCs_Mouse1.27798054
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27575586
91STAT3_23295773_ChIP-Seq_U87_Human1.27138208
92PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26321120
93* YY1_21170310_ChIP-Seq_MESCs_Mouse1.26143850
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25161410
95FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23890193
96ZNF263_19887448_ChIP-Seq_K562_Human1.22977147
97HOXB7_26014856_ChIP-Seq_BT474_Human1.22784925
98ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22723919
99SOX2_19829295_ChIP-Seq_ESCs_Human1.22541958
100NANOG_19829295_ChIP-Seq_ESCs_Human1.22541958
101GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21030527
102EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20708950
103PIAS1_25552417_ChIP-Seq_VCAP_Human1.19257911
104TP63_19390658_ChIP-ChIP_HaCaT_Human1.18847857
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18467411
106BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17987661
107HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17644491
108FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17288330
109KDM5A_27292631_Chip-Seq_BREAST_Human1.17159832
110TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16623189
111HTT_18923047_ChIP-ChIP_STHdh_Human1.16546298
112BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16438961
113P53_21459846_ChIP-Seq_SAOS-2_Human1.15512662
114FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12728177
115MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12029989
116SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11820960
117AR_25329375_ChIP-Seq_VCAP_Human1.11495819
118PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10845590
119ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10388957
120SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10012111
121PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09445639
122REST_21632747_ChIP-Seq_MESCs_Mouse1.08788117
123MYC_19829295_ChIP-Seq_ESCs_Human1.08695232
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08687584
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08687584
126TCF4_23295773_ChIP-Seq_U87_Human1.08512633
127TCF4_22108803_ChIP-Seq_LS180_Human1.08341623
128TTF2_22483619_ChIP-Seq_HELA_Human1.07719817
129TAF2_19829295_ChIP-Seq_ESCs_Human1.07411563
130NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06291565
131ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05847042
132NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05042486
133CBX2_27304074_Chip-Seq_ESCs_Mouse1.04554787
134SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.04266402
135ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03463469
136CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03257679
137E2F1_21310950_ChIP-Seq_MCF-7_Human1.03192906
138KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02435799
139ELK1_19687146_ChIP-ChIP_HELA_Human1.00552410
140CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99142524
141TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.99036236
142OCT4_20526341_ChIP-Seq_ESCs_Human0.98395402
143CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97501962
144NANOG_20526341_ChIP-Seq_ESCs_Human0.97342517
145CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96996745
146KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96881317
147CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96229210
148TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95728378
149BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95109153
150NFE2_27457419_Chip-Seq_LIVER_Mouse0.94810266
151ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94511722
152AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94480322
153SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93896874
154CLOCK_20551151_ChIP-Seq_293T_Human0.93082625
155EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.92665401
156CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92664729
157SMAD4_21799915_ChIP-Seq_A2780_Human0.92340635
158* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92051331
159SMAD4_21741376_ChIP-Seq_EPCs_Human0.90910330
160FOXH1_21741376_ChIP-Seq_EPCs_Human0.90422679
161PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90368046
162HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88432308
163* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88325909
164SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88013105
165CIITA_25753668_ChIP-Seq_RAJI_Human0.87745951
166POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.86618239
167OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85323536
168STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.84060624
169* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.82710684
170SOX2_18692474_ChIP-Seq_MEFs_Mouse0.81776922
171TFEB_21752829_ChIP-Seq_HELA_Human0.80643551
172MYC_22102868_ChIP-Seq_BL_Human0.79855904
173RXRA_24833708_ChIP-Seq_LIVER_Mouse0.79716149
174NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.79480060
175MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.78139757
176SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.77542032
177GATA1_22383799_ChIP-Seq_G1ME_Mouse0.77497252
178FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.76011776
179DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.75901035
180* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.75659235
181ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.74654952
182ELK1_22589737_ChIP-Seq_MCF10A_Human0.71971596

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.58308097
2MP0005360_urolithiasis5.85702500
3MP0003806_abnormal_nucleotide_metabolis5.52250148
4MP0005085_abnormal_gallbladder_physiolo5.17591518
5MP0005365_abnormal_bile_salt4.92389200
6MP0008875_abnormal_xenobiotic_pharmacok3.85201510
7MP0009840_abnormal_foam_cell2.99056274
8MP0005083_abnormal_biliary_tract2.95558865
9MP0010329_abnormal_lipoprotein_level2.75199080
10MP0003136_yellow_coat_color2.61147102
11MP0003252_abnormal_bile_duct2.51186035
12MP0005332_abnormal_amino_acid2.45587065
13MP0001986_abnormal_taste_sensitivity2.35103790
14MP0002876_abnormal_thyroid_physiology2.28417156
15MP0005551_abnormal_eye_electrophysiolog2.15289873
16MP0001666_abnormal_nutrient_absorption2.13177949
17MP0003195_calcinosis2.12267139
18MP0003186_abnormal_redox_activity2.11884600
19MP0008877_abnormal_DNA_methylation2.11059480
20MP0005645_abnormal_hypothalamus_physiol2.05647808
21MP0004043_abnormal_pH_regulation2.04287556
22MP0006036_abnormal_mitochondrial_physio2.03902611
23MP0003693_abnormal_embryo_hatching2.00149450
24MP0008872_abnormal_physiological_respon1.97140413
25MP0001968_abnormal_touch/_nociception1.94215140
26MP0003656_abnormal_erythrocyte_physiolo1.93362676
27MP0001764_abnormal_homeostasis1.93197129
28MP0000609_abnormal_liver_physiology1.92919207
29MP0005319_abnormal_enzyme/_coenzyme1.92027073
30MP0003191_abnormal_cellular_cholesterol1.84965299
31MP0002102_abnormal_ear_morphology1.76857509
32MP0006292_abnormal_olfactory_placode1.74523229
33MP0004142_abnormal_muscle_tone1.72030584
34MP0009697_abnormal_copulation1.64950167
35MP0002736_abnormal_nociception_after1.60556527
36MP0006072_abnormal_retinal_apoptosis1.58797561
37MP0004957_abnormal_blastocyst_morpholog1.58601657
38MP0002638_abnormal_pupillary_reflex1.57477790
39MP0005646_abnormal_pituitary_gland1.57441647
40MP0002118_abnormal_lipid_homeostasis1.55975964
41MP0004019_abnormal_vitamin_homeostasis1.55436035
42MP0004133_heterotaxia1.54521110
43MP0006035_abnormal_mitochondrial_morpho1.53042743
44MP0009046_muscle_twitch1.50841444
45MP0005174_abnormal_tail_pigmentation1.46374674
46MP0002938_white_spotting1.44535411
47MP0000427_abnormal_hair_cycle1.44199693
48MP0005253_abnormal_eye_physiology1.43949140
49MP0009745_abnormal_behavioral_response1.43516113
50MP0005584_abnormal_enzyme/coenzyme_acti1.41434112
51MP0000372_irregular_coat_pigmentation1.41334102
52MP0000598_abnormal_liver_morphology1.38135817
53MP0004145_abnormal_muscle_electrophysio1.36829549
54MP0001485_abnormal_pinna_reflex1.36397767
55MP0004147_increased_porphyrin_level1.32660048
56MP0002160_abnormal_reproductive_system1.31564271
57MP0003868_abnormal_feces_composition1.29851517
58MP0002653_abnormal_ependyma_morphology1.27184104
59MP0010386_abnormal_urinary_bladder1.23509634
60MP0005266_abnormal_metabolism1.22772815
61MP0009643_abnormal_urine_homeostasis1.22024301
62MP0002138_abnormal_hepatobiliary_system1.21255224
63MP0003111_abnormal_nucleus_morphology1.19816362
64MP0000631_abnormal_neuroendocrine_gland1.18220361
65MP0003787_abnormal_imprinting1.17247924
66MP0003718_maternal_effect1.16939432
67MP0005379_endocrine/exocrine_gland_phen1.16700029
68MP0004084_abnormal_cardiac_muscle1.16642747
69MP0010094_abnormal_chromosome_stability1.16550892
70MP0002928_abnormal_bile_duct1.15647948
71MP0002269_muscular_atrophy1.15167505
72MP0001501_abnormal_sleep_pattern1.12040112
73MP0003705_abnormal_hypodermis_morpholog1.11487079
74MP0003077_abnormal_cell_cycle1.09033119
75MP0005389_reproductive_system_phenotype1.08940925
76MP0002234_abnormal_pharynx_morphology1.06979981
77MP0002163_abnormal_gland_morphology1.06249009
78MP0008961_abnormal_basal_metabolism1.04744422
79MP0002272_abnormal_nervous_system1.04282217
80MP0000538_abnormal_urinary_bladder1.02920423
81MP0009053_abnormal_anal_canal1.01845204
82MP0002735_abnormal_chemical_nociception1.01104788
83MP0005376_homeostasis/metabolism_phenot1.00346787
84MP0002837_dystrophic_cardiac_calcinosis0.99826347
85MP0005451_abnormal_body_composition0.99507340
86MP0000383_abnormal_hair_follicle0.98619341
87MP0003011_delayed_dark_adaptation0.96576280
88MP0000569_abnormal_digit_pigmentation0.96570289
89MP0001919_abnormal_reproductive_system0.95933441
90MP0002064_seizures0.94745093
91MP0009763_increased_sensitivity_to0.94403330
92MP0003221_abnormal_cardiomyocyte_apopto0.94169445
93MP0008007_abnormal_cellular_replicative0.93265239
94MP0002132_abnormal_respiratory_system0.91900110
95MP0008469_abnormal_protein_level0.90264377
96MP0005636_abnormal_mineral_homeostasis0.90113530
97MP0006276_abnormal_autonomic_nervous0.89903272
98MP0001730_embryonic_growth_arrest0.89712589
99MP0002557_abnormal_social/conspecific_i0.89613269
100MP0003646_muscle_fatigue0.89544546
101MP0005408_hypopigmentation0.88010734
102MP0005330_cardiomyopathy0.87119291
103MP0000230_abnormal_systemic_arterial0.84815789
104MP0008995_early_reproductive_senescence0.83687451
105MP0002572_abnormal_emotion/affect_behav0.83608212
106MP0004885_abnormal_endolymph0.83407911
107MP0000749_muscle_degeneration0.82676983
108MP0001324_abnormal_eye_pigmentation0.82274021
109MP0002396_abnormal_hematopoietic_system0.81272536
110MP0005220_abnormal_exocrine_pancreas0.80764792
111MP0003567_abnormal_fetal_cardiomyocyte0.80453273
112MP0005386_behavior/neurological_phenoty0.79591772
113MP0004924_abnormal_behavior0.79591772
114MP0004742_abnormal_vestibular_system0.79521224
115MP0008058_abnormal_DNA_repair0.79371339
116MP0009379_abnormal_foot_pigmentation0.79016199
117MP0008775_abnormal_heart_ventricle0.78925797
118MP0003890_abnormal_embryonic-extraembry0.78397218
119MP0002909_abnormal_adrenal_gland0.78254111
120MP0005195_abnormal_posterior_eye0.78076454
121MP0005187_abnormal_penis_morphology0.77761288
122MP0001970_abnormal_pain_threshold0.77293545
123MP0001984_abnormal_olfaction0.76836116
124MP0002277_abnormal_respiratory_mucosa0.75889288
125MP0003698_abnormal_male_reproductive0.75815606
126MP0001853_heart_inflammation0.75667385
127MP0004036_abnormal_muscle_relaxation0.75152727
128MP0001944_abnormal_pancreas_morphology0.75044193
129MP0005410_abnormal_fertilization0.74235009
130MP0009642_abnormal_blood_homeostasis0.74060055
131MP0000358_abnormal_cell_content/0.71657187
132MP0008057_abnormal_DNA_replication0.68794781
133MP0010352_gastrointestinal_tract_polyps0.68760093
134MP0009764_decreased_sensitivity_to0.68048930
135MP0005397_hematopoietic_system_phenotyp0.67784322
136MP0001545_abnormal_hematopoietic_system0.67784322
137MP0003436_decreased_susceptibility_to0.66781026
138MP0008873_increased_physiological_sensi0.65946483
139MP0005023_abnormal_wound_healing0.64501366
140MP0009672_abnormal_birth_weight0.64236366
141MP0009765_abnormal_xenobiotic_induced0.63858381
142MP0005670_abnormal_white_adipose0.63725236
143MP0001756_abnormal_urination0.63461672
144MP0005464_abnormal_platelet_physiology0.62005480
145MP0004130_abnormal_muscle_cell0.61411289
146MP0006054_spinal_hemorrhage0.61090394
147MP0003786_premature_aging0.60755381
148MP0005084_abnormal_gallbladder_morpholo0.58306488
149MP0005395_other_phenotype0.58005017
150MP0005647_abnormal_sex_gland0.57449983
151MP0008932_abnormal_embryonic_tissue0.56919352
152MP0002078_abnormal_glucose_homeostasis0.55529885
153MP0002019_abnormal_tumor_incidence0.54385082
154MP0002080_prenatal_lethality0.53625315
155MP0000350_abnormal_cell_proliferation0.53276984
156MP0002088_abnormal_embryonic_growth/wei0.51908537
157MP0003984_embryonic_growth_retardation0.51860803
158MP0001672_abnormal_embryogenesis/_devel0.50794906
159MP0005380_embryogenesis_phenotype0.50794906
160MP0001697_abnormal_embryo_size0.50324085
161MP0005385_cardiovascular_system_phenoty0.49610973
162MP0001544_abnormal_cardiovascular_syste0.49610973
163MP0004087_abnormal_muscle_fiber0.47025603
164MP0002970_abnormal_white_adipose0.46644447
165MP0001243_abnormal_dermal_layer0.46501155
166MP0001661_extended_life_span0.46399063

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.00947063
2Hypobetalipoproteinemia (HP:0003563)5.65317274
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.48968014
4Intrahepatic cholestasis (HP:0001406)5.36533423
5Deep venous thrombosis (HP:0002625)5.13997375
6Xanthomatosis (HP:0000991)4.62138392
7Prolonged partial thromboplastin time (HP:0003645)4.58937125
8Hyperammonemia (HP:0001987)4.41490661
9Hyperglycinemia (HP:0002154)4.20964107
10Hypolipoproteinemia (HP:0010981)4.09533905
11Abnormality of pyrimidine metabolism (HP:0004353)3.93259218
12Hyperlipoproteinemia (HP:0010980)3.92490725
13Hyperglycinuria (HP:0003108)3.91255207
14Congenital stationary night blindness (HP:0007642)3.90517086
15Pancreatic cysts (HP:0001737)3.84055712
16Hypoglycemic coma (HP:0001325)3.82709286
17Abnormality of glycine metabolism (HP:0010895)3.71860275
18Abnormality of serine family amino acid metabolism (HP:0010894)3.71860275
19Abnormality of methionine metabolism (HP:0010901)3.63273990
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.57243896
21Abnormality of fatty-acid metabolism (HP:0004359)3.53514247
22Abnormality of sulfur amino acid metabolism (HP:0004339)3.49922660
23Ketosis (HP:0001946)3.47045172
24Abnormality of midbrain morphology (HP:0002418)3.45745515
25Molar tooth sign on MRI (HP:0002419)3.45745515
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.39044916
27Pancreatic fibrosis (HP:0100732)3.34719530
28Abnormality of serum amino acid levels (HP:0003112)3.34404019
29Hypoalphalipoproteinemia (HP:0003233)3.30250507
30Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.28335023
31Abnormality of alanine metabolism (HP:0010916)3.28335023
32Hyperalaninemia (HP:0003348)3.28335023
33Hyperbilirubinemia (HP:0002904)3.24844135
34Complement deficiency (HP:0004431)3.24043433
35Cerebral edema (HP:0002181)3.21830514
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.20497719
37Abnormality of the common coagulation pathway (HP:0010990)3.19951167
38Lethargy (HP:0001254)3.14689627
39Large for gestational age (HP:0001520)3.13585964
40Nephronophthisis (HP:0000090)3.13496075
41Abnormality of dicarboxylic acid metabolism (HP:0010995)3.12589327
42Dicarboxylic aciduria (HP:0003215)3.12589327
43Hepatic necrosis (HP:0002605)3.11262520
44True hermaphroditism (HP:0010459)3.08022095
45Fat malabsorption (HP:0002630)3.06360756
46Abnormality of glutamine family amino acid metabolism (HP:0010902)3.05378536
47Abnormality of the intrinsic pathway (HP:0010989)3.01308648
48Hyperventilation (HP:0002883)3.01215114
49Abnormality of the renal cortex (HP:0011035)3.00973905
50Joint hemorrhage (HP:0005261)2.95921929
51Attenuation of retinal blood vessels (HP:0007843)2.93512459
52Epidermoid cyst (HP:0200040)2.86234539
53Delayed CNS myelination (HP:0002188)2.84511653
54Chronic hepatic failure (HP:0100626)2.83871403
55Abnormality of nucleobase metabolism (HP:0010932)2.77905469
56Abnormality of the renal medulla (HP:0100957)2.70198090
57Polydipsia (HP:0001959)2.69293339
58Abnormal drinking behavior (HP:0030082)2.69293339
59Metabolic acidosis (HP:0001942)2.67684197
60Nausea (HP:0002018)2.65024642
61Generalized aminoaciduria (HP:0002909)2.64772674
62Type II lissencephaly (HP:0007260)2.61748540
63Increased serum pyruvate (HP:0003542)2.57537058
64Abnormality of glycolysis (HP:0004366)2.57537058
65Hepatocellular necrosis (HP:0001404)2.51250416
66Hypercholesterolemia (HP:0003124)2.50520824
67Rhabdomyolysis (HP:0003201)2.50387683
68Multiple enchondromatosis (HP:0005701)2.50157846
69Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.48069555
70Decreased activity of mitochondrial respiratory chain (HP:0008972)2.48069555
71Hepatocellular carcinoma (HP:0001402)2.47479189
72Abnormal biliary tract physiology (HP:0012439)2.42585895
73Bile duct proliferation (HP:0001408)2.42585895
74Abnormality of complement system (HP:0005339)2.41120945
75Birth length less than 3rd percentile (HP:0003561)2.39856134
76Steatorrhea (HP:0002570)2.38721876
77Ragged-red muscle fibers (HP:0003200)2.38587228
78Tubular atrophy (HP:0000092)2.38117652
79Ketoacidosis (HP:0001993)2.37175757
80Spastic diplegia (HP:0001264)2.37045616
81Gout (HP:0001997)2.36816034
82Gaze-evoked nystagmus (HP:0000640)2.35343096
83Medial flaring of the eyebrow (HP:0010747)2.35080915
84Patellar aplasia (HP:0006443)2.34248532
85Hypochromic microcytic anemia (HP:0004840)2.34099567
86Opisthotonus (HP:0002179)2.33253383
87Increased serum lactate (HP:0002151)2.32402848
88Genetic anticipation (HP:0003743)2.32299571
89Hypothermia (HP:0002045)2.31304158
90Abnormal cartilage morphology (HP:0002763)2.31140143
91Acute encephalopathy (HP:0006846)2.30938929
92Abolished electroretinogram (ERG) (HP:0000550)2.28558944
93Abnormality of the pons (HP:0007361)2.28501635
94Methylmalonic acidemia (HP:0002912)2.26069272
95Pendular nystagmus (HP:0012043)2.25970499
96Cholelithiasis (HP:0001081)2.25149240
97CNS demyelination (HP:0007305)2.23737174
98Vomiting (HP:0002013)2.23565194
99Abnormality of the heme biosynthetic pathway (HP:0010472)2.23501449
100Concave nail (HP:0001598)2.23140685
101Lactic acidosis (HP:0003128)2.23011851
102Cystic liver disease (HP:0006706)2.21130793
103Inability to walk (HP:0002540)2.20991122
104Methylmalonic aciduria (HP:0012120)2.20708522
105Abnormality of purine metabolism (HP:0004352)2.20228594
106Aplasia/Hypoplasia of the patella (HP:0006498)2.18910514
107Polyuria (HP:0000103)2.18315565
108Hypoplasia of the pons (HP:0012110)2.18139293
109Progressive cerebellar ataxia (HP:0002073)2.17061543
110Abnormal gallbladder morphology (HP:0012437)2.16564884
111Conjugated hyperbilirubinemia (HP:0002908)2.13700810
112Oral leukoplakia (HP:0002745)2.13016884
113Fair hair (HP:0002286)2.10690353
114Myoglobinuria (HP:0002913)2.09938355
115Proximal tubulopathy (HP:0000114)2.09646669
116Megaloblastic anemia (HP:0001889)2.08625867
117Furrowed tongue (HP:0000221)2.08297569
118Progressive inability to walk (HP:0002505)2.07808425
119Spontaneous abortion (HP:0005268)2.07612905
120Hypomagnesemia (HP:0002917)2.05971738
121Abnormal gallbladder physiology (HP:0012438)2.03641027
122Cholecystitis (HP:0001082)2.03641027
123Poikilocytosis (HP:0004447)2.03250986
124Abnormality of transition element cation homeostasis (HP:0011030)2.02984203
125Sclerocornea (HP:0000647)2.02541348
126Abnormality of iron homeostasis (HP:0011031)2.00914598
127Congenital, generalized hypertrichosis (HP:0004540)2.00762808
128Abnormal number of erythroid precursors (HP:0012131)1.99208294
129Lipid accumulation in hepatocytes (HP:0006561)1.99077013
130Increased CSF lactate (HP:0002490)1.98385679
131Decreased electroretinogram (ERG) amplitude (HP:0000654)1.97984599
132Brushfield spots (HP:0001088)1.97058240
133Tachypnea (HP:0002789)1.95200050
134Skin nodule (HP:0200036)1.94492161
135Progressive macrocephaly (HP:0004481)1.93915478
136Abnormality of urine glucose concentration (HP:0011016)1.93280198
137Glycosuria (HP:0003076)1.93280198
138Late onset (HP:0003584)1.93090536
1393-Methylglutaconic aciduria (HP:0003535)1.92324129
140Clumsiness (HP:0002312)1.91784807
141Broad-based gait (HP:0002136)1.91302618
142Increased serum ferritin (HP:0003281)1.90277223
143Congenital hepatic fibrosis (HP:0002612)1.89937458
144Irritability (HP:0000737)1.89403792
145Malnutrition (HP:0004395)1.89309750
146Reticulocytosis (HP:0001923)1.87745788
147Abnormal rod and cone electroretinograms (HP:0008323)1.87352129
148Anencephaly (HP:0002323)1.86851545
149Abnormal mitochondria in muscle tissue (HP:0008316)1.86390261
150Increased muscle lipid content (HP:0009058)1.84748873
151Decreased central vision (HP:0007663)1.84527086
152Renal cortical cysts (HP:0000803)1.84060916
153Severe muscular hypotonia (HP:0006829)1.83124423
154Absent thumb (HP:0009777)1.82278852
155Optic disc pallor (HP:0000543)1.82110184
156Lissencephaly (HP:0001339)1.81271422
157Acanthocytosis (HP:0001927)1.79876565
158Rib fusion (HP:0000902)1.78900822
159Mitochondrial inheritance (HP:0001427)1.77980951
160Abnormal urine output (HP:0012590)1.77473499
161Protruding tongue (HP:0010808)1.77408178
162Acute necrotizing encephalopathy (HP:0006965)1.77392029
163Male pseudohermaphroditism (HP:0000037)1.77299425
164Bony spicule pigmentary retinopathy (HP:0007737)1.76986658
165Duplicated collecting system (HP:0000081)1.75835314
166Microvesicular hepatic steatosis (HP:0001414)1.75662714
167Abnormality of homocysteine metabolism (HP:0010919)1.75092154
168Homocystinuria (HP:0002156)1.75092154
169Myocardial infarction (HP:0001658)1.74782665
170Neonatal onset (HP:0003623)1.73867562
171Gait imbalance (HP:0002141)1.73811547
172Abnormal protein N-linked glycosylation (HP:0012347)1.72425657
173Abnormal protein glycosylation (HP:0012346)1.72425657
174Abnormal glycosylation (HP:0012345)1.72425657

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.17084323
2BCKDK5.21507656
3BUB13.80214268
4BMPR1B3.54932928
5EIF2AK13.46080068
6PIK3CG3.09097518
7WEE12.93827010
8ADRBK22.87479543
9FLT32.87093758
10NEK12.84568840
11NME22.59883829
12MAP4K22.50283013
13WNK42.35545841
14GRK12.33875756
15NUAK12.29490062
16WNK32.28915205
17PKN22.21166687
18STK162.16518345
19INSRR2.15033766
20MAP2K31.99963439
21MAP3K111.94672346
22ERN11.90592998
23MKNK21.72796369
24MAP3K101.71274981
25STK391.70984542
26OXSR11.70677341
27MST1R1.65670316
28EIF2AK31.62924556
29VRK21.58829116
30RPS6KB21.54507353
31PDK41.54411440
32PDK31.54411440
33SRPK11.53233609
34KDR1.48824134
35TESK21.47985941
36MAPK151.42088266
37FGFR41.40845344
38PIM21.39302439
39NEK91.38280616
40TSSK61.36123339
41EPHA21.35839017
42BRSK21.33638773
43MAP3K31.31899920
44MAPK131.31884234
45ACVR1B1.30574489
46SIK11.29247618
47TRIB31.28801124
48OBSCN1.26586032
49PAK31.24023792
50AKT31.23954755
51PLK41.20363369
52CAMKK21.19059203
53DAPK21.17280127
54RPS6KA41.15753822
55PLK11.12932707
56TAF11.12579053
57ABL21.08081465
58MAP3K41.07440367
59ADRBK11.06849331
60IRAK31.06235103
61PHKG21.04684396
62PHKG11.04684396
63CASK1.04572111
64TAOK21.02304045
65MAPKAPK31.00370813
66NEK20.97897451
67MAP3K80.97425888
68TTK0.96261080
69TXK0.95878120
70TYK20.92957169
71MAPK110.92281989
72BRD40.91975530
73CDK40.91560434
74CDK70.91112940
75PRKCG0.88683891
76TGFBR10.84471539
77AURKB0.83777064
78TNIK0.82061104
79CAMK1D0.81819122
80MUSK0.81074791
81CDC70.79280994
82DYRK30.78945735
83RPS6KA50.78830187
84DYRK20.77468009
85MAP2K60.77384653
86PDK20.77313918
87MYLK0.74758797
88PRKCE0.73040715
89TLK10.72824056
90VRK10.71875771
91ERBB40.71785251
92SCYL20.71488925
93GRK60.70902846
94FGFR20.69976997
95IKBKB0.69658453
96PBK0.69371041
97AURKA0.68092769
98MAP3K50.67994943
99CSNK1G10.67752113
100MET0.67314087
101STK38L0.67210770
102TTN0.64115989
103NME10.62215447
104PASK0.62112132
105STK100.61625305
106TEC0.61015710
107STK40.60955366
108CSNK1A1L0.60498564
109PRKAA20.60402972
110PRKAA10.60365090
111KIT0.59865072
112BRSK10.59574522
113PINK10.59561827
114ATR0.59199762
115MAP2K70.57967719
116CHEK20.57934635
117LRRK20.57682035
118CSNK2A10.57502781
119PIM10.57322594
120TIE10.57317184
121BRAF0.56127526
122PAK40.55745473
123CSNK1G30.54790234
124CSNK1G20.54590352
125CHUK0.53823822
126CSNK2A20.53798026
127MATK0.53644981
128MAP4K10.52586402
129PNCK0.52446810
130CSNK1A10.50495561
131CAMK1G0.48844275
132STK240.48810369
133ZAK0.47555859
134TRPM70.47471677
135PIK3CA0.47373586
136PRKCQ0.45577477
137CAMK10.45287903
138MAP3K140.44638898
139ZAP700.44331335
140TRIM280.44129972
141STK110.44071730
142PRKACA0.43877472
143MST40.41864065
144MAPKAPK50.41672829
145MAP2K40.40851057
146MKNK10.40655165
147MAPK40.39720799
148EIF2AK20.39268468
149CSNK1D0.39224444
150PKN10.38610508
151NLK0.38123302
152PLK30.36814961
153NTRK30.36290338
154TBK10.36104444
155CHEK10.35629519
156TNK20.35263681
157STK30.34775220
158ILK0.34122003
159CAMK2A0.33590461
160PRKCA0.33266880
161MELK0.33219928
162FER0.33139723
163ATM0.32427719
164MAPK120.31509680
165AKT20.30417155
166PRKCI0.30080328
167IRAK40.29903037
168TAOK30.29154492

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.31205304
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.99399026
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.71374922
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.55896490
5Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.50449713
6Arginine biosynthesis_Homo sapiens_hsa002202.36739789
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.31678241
8Fatty acid degradation_Homo sapiens_hsa000712.22808448
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.21864465
10Nitrogen metabolism_Homo sapiens_hsa009102.10814247
11Tryptophan metabolism_Homo sapiens_hsa003802.06632655
12One carbon pool by folate_Homo sapiens_hsa006701.99372397
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.97877324
14Drug metabolism - other enzymes_Homo sapiens_hsa009831.95279949
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.93965064
16Propanoate metabolism_Homo sapiens_hsa006401.92991920
17Selenocompound metabolism_Homo sapiens_hsa004501.92747559
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.89874993
19Proteasome_Homo sapiens_hsa030501.88483819
20Folate biosynthesis_Homo sapiens_hsa007901.88140075
21Complement and coagulation cascades_Homo sapiens_hsa046101.87392542
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.86874634
23Biosynthesis of amino acids_Homo sapiens_hsa012301.80781552
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.80731804
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78528197
26Peroxisome_Homo sapiens_hsa041461.78289719
27Carbon metabolism_Homo sapiens_hsa012001.75192910
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.71814266
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62527357
30Butanoate metabolism_Homo sapiens_hsa006501.59218473
31Pyruvate metabolism_Homo sapiens_hsa006201.56188116
32Phototransduction_Homo sapiens_hsa047441.55999442
33Sulfur relay system_Homo sapiens_hsa041221.54714486
34Caffeine metabolism_Homo sapiens_hsa002321.54604097
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.49877840
36Fatty acid metabolism_Homo sapiens_hsa012121.48397234
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48190561
38DNA replication_Homo sapiens_hsa030301.46676545
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.44750878
40Chemical carcinogenesis_Homo sapiens_hsa052041.44279962
41beta-Alanine metabolism_Homo sapiens_hsa004101.42132933
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.39469760
43Ribosome_Homo sapiens_hsa030101.39190120
44Fanconi anemia pathway_Homo sapiens_hsa034601.32445959
45PPAR signaling pathway_Homo sapiens_hsa033201.31478518
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.31263046
47Phenylalanine metabolism_Homo sapiens_hsa003601.29978976
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29760797
49Histidine metabolism_Homo sapiens_hsa003401.29481375
50Pentose phosphate pathway_Homo sapiens_hsa000301.25895720
51Basal transcription factors_Homo sapiens_hsa030221.25668200
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25287115
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17777101
54Mismatch repair_Homo sapiens_hsa034301.17668614
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17541192
56Tyrosine metabolism_Homo sapiens_hsa003501.16409034
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16403783
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16312516
59Cyanoamino acid metabolism_Homo sapiens_hsa004601.15165378
60Steroid hormone biosynthesis_Homo sapiens_hsa001401.13445977
61Pyrimidine metabolism_Homo sapiens_hsa002401.13101240
62Retinol metabolism_Homo sapiens_hsa008301.11492028
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10819298
64Arginine and proline metabolism_Homo sapiens_hsa003301.07786845
65Fat digestion and absorption_Homo sapiens_hsa049751.05643971
66Fatty acid elongation_Homo sapiens_hsa000621.04911409
67Glutathione metabolism_Homo sapiens_hsa004801.04256629
68Vitamin B6 metabolism_Homo sapiens_hsa007501.03831155
69Arachidonic acid metabolism_Homo sapiens_hsa005901.03703204
70Starch and sucrose metabolism_Homo sapiens_hsa005001.01211288
71RNA polymerase_Homo sapiens_hsa030201.01147215
72Sulfur metabolism_Homo sapiens_hsa009201.00954385
73Staphylococcus aureus infection_Homo sapiens_hsa051501.00061613
74Ether lipid metabolism_Homo sapiens_hsa005650.89720603
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88652765
76Nicotine addiction_Homo sapiens_hsa050330.88509867
77Fructose and mannose metabolism_Homo sapiens_hsa000510.81225644
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.81186591
79RNA transport_Homo sapiens_hsa030130.80331518
80Alzheimers disease_Homo sapiens_hsa050100.77476071
81Base excision repair_Homo sapiens_hsa034100.77146073
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71625446
83Bile secretion_Homo sapiens_hsa049760.68329161
84Metabolic pathways_Homo sapiens_hsa011000.68137605
85Taste transduction_Homo sapiens_hsa047420.67055792
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.65229891
87Nucleotide excision repair_Homo sapiens_hsa034200.64178171
88Galactose metabolism_Homo sapiens_hsa000520.64042624
89Steroid biosynthesis_Homo sapiens_hsa001000.63814804
90Vitamin digestion and absorption_Homo sapiens_hsa049770.63258686
91Cardiac muscle contraction_Homo sapiens_hsa042600.63161827
92Parkinsons disease_Homo sapiens_hsa050120.61274097
93Spliceosome_Homo sapiens_hsa030400.60257274
94Non-homologous end-joining_Homo sapiens_hsa034500.59062054
95Homologous recombination_Homo sapiens_hsa034400.58895054
96Regulation of autophagy_Homo sapiens_hsa041400.58611192
97ABC transporters_Homo sapiens_hsa020100.57441110
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57074486
99Oxidative phosphorylation_Homo sapiens_hsa001900.51992612
100Circadian rhythm_Homo sapiens_hsa047100.46916456
101Insulin secretion_Homo sapiens_hsa049110.45858486
102Lysine degradation_Homo sapiens_hsa003100.45398584
103Glycerolipid metabolism_Homo sapiens_hsa005610.44534558
104Ovarian steroidogenesis_Homo sapiens_hsa049130.42339317
105Serotonergic synapse_Homo sapiens_hsa047260.39883414
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39866946
107Protein export_Homo sapiens_hsa030600.39439852
108Purine metabolism_Homo sapiens_hsa002300.38475887
109Collecting duct acid secretion_Homo sapiens_hsa049660.38322035
110Morphine addiction_Homo sapiens_hsa050320.37073592
111Olfactory transduction_Homo sapiens_hsa047400.35485951
112Huntingtons disease_Homo sapiens_hsa050160.31510561
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25347318
114RNA degradation_Homo sapiens_hsa030180.24137059
115Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.23899576
116Cell cycle_Homo sapiens_hsa041100.23322354
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.18662468
118Systemic lupus erythematosus_Homo sapiens_hsa053220.17971750
119p53 signaling pathway_Homo sapiens_hsa041150.16771978
120Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.16244090
121Linoleic acid metabolism_Homo sapiens_hsa005910.14441050
122Insulin resistance_Homo sapiens_hsa049310.12800554
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.12784361
124Legionellosis_Homo sapiens_hsa051340.12015636
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11062881

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