SPRYD7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuronal action potential propagation (GO:0019227)4.20225050
2proteasome assembly (GO:0043248)4.15750675
3protein complex biogenesis (GO:0070271)4.13766450
4synaptic vesicle exocytosis (GO:0016079)4.01949203
5water-soluble vitamin biosynthetic process (GO:0042364)3.98394981
6regulation of synaptic vesicle exocytosis (GO:2000300)3.95316377
7regulation of short-term neuronal synaptic plasticity (GO:0048172)3.86313406
8respiratory chain complex IV assembly (GO:0008535)3.83740937
9mitochondrial respiratory chain complex assembly (GO:0033108)3.81280224
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.80835603
11mitochondrial respiratory chain complex I assembly (GO:0032981)3.80835603
12NADH dehydrogenase complex assembly (GO:0010257)3.80835603
13response to pheromone (GO:0019236)3.72259951
14behavioral response to nicotine (GO:0035095)3.72200486
15L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.62825760
16regulation of synaptic vesicle transport (GO:1902803)3.62436070
17glutamate secretion (GO:0014047)3.60183106
18ATP hydrolysis coupled proton transport (GO:0015991)3.58588198
19energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.58588198
20platelet dense granule organization (GO:0060155)3.58308243
21cellular ketone body metabolic process (GO:0046950)3.54765606
22neuron cell-cell adhesion (GO:0007158)3.50046235
23cytochrome complex assembly (GO:0017004)3.45959927
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.44078584
25phagosome maturation (GO:0090382)3.38035621
26synaptic vesicle maturation (GO:0016188)3.36385025
27positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.34828560
28negative regulation of amino acid transport (GO:0051956)3.33074591
29cullin deneddylation (GO:0010388)3.24824195
30L-methionine salvage (GO:0071267)3.24759395
31L-methionine biosynthetic process (GO:0071265)3.24759395
32amino acid salvage (GO:0043102)3.24759395
33DNA deamination (GO:0045006)3.24072655
34regulation of hexokinase activity (GO:1903299)3.23289193
35regulation of glucokinase activity (GO:0033131)3.23289193
36branched-chain amino acid catabolic process (GO:0009083)3.21519517
37ketone body metabolic process (GO:1902224)3.21312994
38transferrin transport (GO:0033572)3.20965393
39regulation of glutamate secretion (GO:0014048)3.11349053
40protein-cofactor linkage (GO:0018065)3.11293607
41neuromuscular process controlling posture (GO:0050884)3.06335719
42establishment of protein localization to mitochondrial membrane (GO:0090151)3.06251741
43pseudouridine synthesis (GO:0001522)3.05467936
44ionotropic glutamate receptor signaling pathway (GO:0035235)3.05414636
45regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.02296098
46protein localization to synapse (GO:0035418)3.02038733
47neurotransmitter secretion (GO:0007269)3.01049958
48protein deneddylation (GO:0000338)2.99522681
49negative regulation of synaptic transmission, GABAergic (GO:0032229)2.97657032
50RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.96780813
51tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.96780813
52trivalent inorganic cation transport (GO:0072512)2.93453809
53ferric iron transport (GO:0015682)2.93453809
54vocalization behavior (GO:0071625)2.92704508
55gamma-aminobutyric acid signaling pathway (GO:0007214)2.89037538
56chaperone-mediated protein transport (GO:0072321)2.88055582
57protein polyglutamylation (GO:0018095)2.87521817
58glutamate receptor signaling pathway (GO:0007215)2.84146425
59positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.83417782
60regulation of long-term neuronal synaptic plasticity (GO:0048169)2.82956171
61signal peptide processing (GO:0006465)2.81990287
62proton transport (GO:0015992)2.81346787
63maturation of 5.8S rRNA (GO:0000460)2.81130921
64ubiquinone metabolic process (GO:0006743)2.80931933
65regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.79384539
66regulation of mitochondrial translation (GO:0070129)2.79358477
67respiratory electron transport chain (GO:0022904)2.79250217
68nucleotide transmembrane transport (GO:1901679)2.79093961
69positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.79033358
70preassembly of GPI anchor in ER membrane (GO:0016254)2.78195581
71dopamine transport (GO:0015872)2.77798230
72gamma-aminobutyric acid transport (GO:0015812)2.77671480
73hydrogen transport (GO:0006818)2.76304261
74regulation of glutamate receptor signaling pathway (GO:1900449)2.75205221
75electron transport chain (GO:0022900)2.74781733
76membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.73623930
77mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.73003366
78mannosylation (GO:0097502)2.71816699
79inositol phosphate catabolic process (GO:0071545)2.71612674
80neurotransmitter transport (GO:0006836)2.71452168
81behavioral response to cocaine (GO:0048148)2.69122803
82sarcoplasmic reticulum calcium ion transport (GO:0070296)2.67894094
83fucose catabolic process (GO:0019317)2.65656471
84L-fucose metabolic process (GO:0042354)2.65656471
85L-fucose catabolic process (GO:0042355)2.65656471
86regulation of neuronal synaptic plasticity (GO:0048168)2.65616310
87regulation of synapse structural plasticity (GO:0051823)2.64215572
88neuron-neuron synaptic transmission (GO:0007270)2.63612495
89ubiquinone biosynthetic process (GO:0006744)2.62282938
90regulation of neurotransmitter secretion (GO:0046928)2.62088102
91regulation of vesicle fusion (GO:0031338)2.61660798
92eosinophil chemotaxis (GO:0048245)2.61511855
93ATP synthesis coupled proton transport (GO:0015986)2.60990302
94energy coupled proton transport, down electrochemical gradient (GO:0015985)2.60990302
95methionine biosynthetic process (GO:0009086)2.60798344
96positive regulation of synaptic transmission, GABAergic (GO:0032230)2.60425058
97glycerophospholipid catabolic process (GO:0046475)2.58735769
98GPI anchor metabolic process (GO:0006505)2.57335573
99regulation of amino acid transport (GO:0051955)2.56725599
100ATP biosynthetic process (GO:0006754)2.56226571
101serotonin metabolic process (GO:0042428)2.56109523
102locomotory exploration behavior (GO:0035641)2.55785662
103nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.55411668
104intracellular pH reduction (GO:0051452)2.55315786
105hydrogen peroxide biosynthetic process (GO:0050665)2.54795299
106purine nucleoside triphosphate biosynthetic process (GO:0009145)2.54661408
107cellular potassium ion homeostasis (GO:0030007)2.53914617
108negative regulation of dendrite morphogenesis (GO:0050774)2.53683315
109prenylation (GO:0097354)2.53525138
110protein prenylation (GO:0018342)2.53525138
111exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.52914979
112exploration behavior (GO:0035640)2.52700525
113detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.52152981
114protein localization to cilium (GO:0061512)2.51925649
115response to histamine (GO:0034776)2.50985593
116regulation of neuron projection regeneration (GO:0070570)2.50216037
117regulation of axon regeneration (GO:0048679)2.50216037
118vesicle transport along microtubule (GO:0047496)2.49845453
119purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.49456086
120rRNA modification (GO:0000154)2.48874516
121regulation of neurotransmitter levels (GO:0001505)2.47963171
122negative regulation of neurotransmitter transport (GO:0051589)2.47890696
123phosphorylated carbohydrate dephosphorylation (GO:0046838)2.47670246
124inositol phosphate dephosphorylation (GO:0046855)2.47670246
125detection of calcium ion (GO:0005513)2.47437245
126anterograde synaptic vesicle transport (GO:0048490)2.47332825
127regulation of neurotransmitter transport (GO:0051588)2.46728142
128positive regulation of neurotransmitter transport (GO:0051590)2.46182752
129presynaptic membrane assembly (GO:0097105)2.45717446
130piRNA metabolic process (GO:0034587)2.45692055
131presynaptic membrane organization (GO:0097090)2.45268045
132positive regulation of meiosis (GO:0045836)2.44281444
133long-term synaptic potentiation (GO:0060291)2.44198481
134cellular copper ion homeostasis (GO:0006878)2.43275566
135long-chain fatty acid biosynthetic process (GO:0042759)2.42957788
136establishment of synaptic vesicle localization (GO:0097480)2.42179878
137synaptic vesicle transport (GO:0048489)2.42179878
138regulation of neurotransmitter uptake (GO:0051580)2.41871112
139positive regulation of neurotransmitter secretion (GO:0001956)2.41092966
140branched-chain amino acid metabolic process (GO:0009081)2.40319591
141calcium ion-dependent exocytosis (GO:0017156)2.40011923
142C4-dicarboxylate transport (GO:0015740)2.39448705
143synaptic transmission, glutamatergic (GO:0035249)2.39000352
144negative regulation of amine transport (GO:0051953)2.38477145
145transcription elongation from RNA polymerase III promoter (GO:0006385)2.37168556
146termination of RNA polymerase III transcription (GO:0006386)2.37168556
147DNA double-strand break processing (GO:0000729)2.36798165
148neurotransmitter-gated ion channel clustering (GO:0072578)2.36387171
149synaptic transmission, cholinergic (GO:0007271)2.36073598
150C-terminal protein lipidation (GO:0006501)2.35625493
151regulation of cilium movement (GO:0003352)2.35550379
152regulation of synaptic transmission, dopaminergic (GO:0032225)2.35541445
153aspartate family amino acid biosynthetic process (GO:0009067)2.35375871
154anterograde axon cargo transport (GO:0008089)2.34645229
155primary amino compound metabolic process (GO:1901160)2.34030519
156tRNA processing (GO:0008033)2.33770823
157long-term memory (GO:0007616)2.33691734
158regulation of cellular amino acid metabolic process (GO:0006521)2.33419433
159negative regulation of interleukin-17 production (GO:0032700)2.33346229
160pH reduction (GO:0045851)2.33112852
161hydrogen ion transmembrane transport (GO:1902600)2.32120108
162peptidyl-histidine modification (GO:0018202)2.31265483
163neuron recognition (GO:0008038)2.31161766
164positive regulation of mitochondrial fission (GO:0090141)2.30848918
165protein targeting to mitochondrion (GO:0006626)2.30379035
166intracellular protein transmembrane import (GO:0044743)2.30375538
167positive regulation of meiotic cell cycle (GO:0051446)2.30297991
168regulation of excitatory postsynaptic membrane potential (GO:0060079)2.29975172
169proline transport (GO:0015824)2.28927268
170GTP biosynthetic process (GO:0006183)2.28016219
171synaptic transmission, dopaminergic (GO:0001963)2.27876507
172auditory receptor cell stereocilium organization (GO:0060088)2.27689594
173organelle transport along microtubule (GO:0072384)2.27433984
174positive regulation of heat generation (GO:0031652)2.26873516
175protein neddylation (GO:0045116)2.26736887
176establishment of vesicle localization (GO:0051650)2.26280944
177dopamine biosynthetic process (GO:0042416)2.26180320
178response to auditory stimulus (GO:0010996)2.25540386
179membrane depolarization during action potential (GO:0086010)2.24865889
180regulation of synaptic plasticity (GO:0048167)2.24523172
181cellular response to exogenous dsRNA (GO:0071360)2.24204472
182neuronal action potential (GO:0019228)2.23172150

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.16470903
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.43813255
3GBX2_23144817_ChIP-Seq_PC3_Human3.23035746
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.21175674
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.96341986
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.77922059
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.74732956
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.65307453
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.64427037
10TAF15_26573619_Chip-Seq_HEK293_Human2.53666390
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.53221496
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36789070
13VDR_22108803_ChIP-Seq_LS180_Human2.35693713
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.33437943
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.27347926
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.26421165
17REST_21632747_ChIP-Seq_MESCs_Mouse2.26216329
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17395971
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.16393089
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.14800058
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.03542310
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.99319445
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.95281687
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91718472
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.91599015
26P300_19829295_ChIP-Seq_ESCs_Human1.86993116
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85386916
28ELK1_19687146_ChIP-ChIP_HELA_Human1.85008423
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.82562471
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79897610
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79871868
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.75908966
33EWS_26573619_Chip-Seq_HEK293_Human1.75218393
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74648661
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.74238218
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73684170
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.72694329
38EZH2_18974828_ChIP-Seq_MESCs_Mouse1.71856445
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.71856445
40SMAD4_21799915_ChIP-Seq_A2780_Human1.69949731
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69862147
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.69240104
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.66023720
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65343183
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.64967974
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.64504489
47MYC_18940864_ChIP-ChIP_HL60_Human1.64080918
48VDR_23849224_ChIP-Seq_CD4+_Human1.63161008
49IGF1R_20145208_ChIP-Seq_DFB_Human1.61880154
50TP53_22573176_ChIP-Seq_HFKS_Human1.59060380
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56830908
52ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.47924268
53AR_25329375_ChIP-Seq_VCAP_Human1.46357028
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45542484
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.44857116
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42928680
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.42263967
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42213674
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.40916243
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40042437
61CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.39722282
62Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.39300282
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38452546
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37242455
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.37018772
66RNF2_27304074_Chip-Seq_ESCs_Mouse1.35743542
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33329826
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32057358
69RARB_27405468_Chip-Seq_BRAIN_Mouse1.31456913
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.31084710
71IRF8_21731497_ChIP-ChIP_J774_Mouse1.30700424
72ER_23166858_ChIP-Seq_MCF-7_Human1.29298835
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28942110
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28942110
75ZNF274_21170338_ChIP-Seq_K562_Hela1.26932871
76RNF2_27304074_Chip-Seq_NSC_Mouse1.26219845
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24093003
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23935980
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22701113
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.22130609
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.21882367
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21831119
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.21831119
84CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20163739
85AR_21572438_ChIP-Seq_LNCaP_Human1.19750882
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19300238
87FUS_26573619_Chip-Seq_HEK293_Human1.18204631
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15286754
89P53_22387025_ChIP-Seq_ESCs_Mouse1.15172568
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14002635
91EZH2_27294783_Chip-Seq_NPCs_Mouse1.12940028
92NCOR_22424771_ChIP-Seq_293T_Human1.12861114
93PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.11809555
94E2F1_18555785_Chip-Seq_ESCs_Mouse1.11494408
95FOXP3_21729870_ChIP-Seq_TREG_Human1.11362392
96FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11260287
97PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11197786
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10548460
99NFE2_27457419_Chip-Seq_LIVER_Mouse1.10091282
100SMAD_19615063_ChIP-ChIP_OVARY_Human1.09524479
101NOTCH1_21737748_ChIP-Seq_TLL_Human1.09450204
102HTT_18923047_ChIP-ChIP_STHdh_Human1.09147169
103BCAT_22108803_ChIP-Seq_LS180_Human1.08672719
104CBX2_27304074_Chip-Seq_ESCs_Mouse1.08249075
105TCF4_23295773_ChIP-Seq_U87_Human1.08156068
106SALL1_21062744_ChIP-ChIP_HESCs_Human1.07908197
107CMYC_18555785_Chip-Seq_ESCs_Mouse1.07720298
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07218716
109KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07119276
110JUN_21703547_ChIP-Seq_K562_Human1.06242394
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05963233
112AR_20517297_ChIP-Seq_VCAP_Human1.05857423
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05552170
114THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05479173
115PRDM14_20953172_ChIP-Seq_ESCs_Human1.05033679
116MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04999015
117STAT3_18555785_Chip-Seq_ESCs_Mouse1.03896211
118P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03699787
119FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03649490
120SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03065640
121IRF1_19129219_ChIP-ChIP_H3396_Human1.01567385
122RUNX2_22187159_ChIP-Seq_PCA_Human1.01216617
123SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00907696
124NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00728796
125EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00675989
126FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99603280
127SOX2_18555785_Chip-Seq_ESCs_Mouse0.99581074
128RUNX1_27457419_Chip-Seq_LIVER_Mouse0.99304797
129TP53_18474530_ChIP-ChIP_U2OS_Human0.99161300
130AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98561245
131CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98196539
132STAT3_23295773_ChIP-Seq_U87_Human0.98104483
133CRX_20693478_ChIP-Seq_RETINA_Mouse0.97335311
134IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97254424
135CBP_20019798_ChIP-Seq_JUKART_Human0.97254424
136PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97189121
137HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96077726
138RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95925682
139FLI1_21867929_ChIP-Seq_TH2_Mouse0.95681129
140GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95436310
141GABP_19822575_ChIP-Seq_HepG2_Human0.95429956
142KDM2B_26808549_Chip-Seq_REH_Human0.94911664
143NANOG_19829295_ChIP-Seq_ESCs_Human0.94475098
144SOX2_19829295_ChIP-Seq_ESCs_Human0.94475098
145SOX2_21211035_ChIP-Seq_LN229_Gbm0.93901158
146CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93457193
147NMYC_18555785_Chip-Seq_ESCs_Mouse0.93229239
148TCF4_22108803_ChIP-Seq_LS180_Human0.92659381

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.52274050
2MP0004859_abnormal_synaptic_plasticity3.88619298
3MP0009046_muscle_twitch3.07189549
4MP0004270_analgesia2.95358108
5MP0001968_abnormal_touch/_nociception2.92194803
6MP0003635_abnormal_synaptic_transmissio2.90694587
7MP0006276_abnormal_autonomic_nervous2.75923974
8MP0001501_abnormal_sleep_pattern2.75682628
9MP0009745_abnormal_behavioral_response2.74716670
10MP0002064_seizures2.65973244
11MP0002102_abnormal_ear_morphology2.59392508
12MP0002735_abnormal_chemical_nociception2.56403457
13MP0002736_abnormal_nociception_after2.46503882
14MP0002063_abnormal_learning/memory/cond2.43514434
15MP0002822_catalepsy2.37951345
16MP0002734_abnormal_mechanical_nocicepti2.31167661
17MP0002272_abnormal_nervous_system2.23803217
18MP0003195_calcinosis2.17283386
19MP0004147_increased_porphyrin_level2.17035787
20MP0002572_abnormal_emotion/affect_behav2.15838958
21MP0001440_abnormal_grooming_behavior2.14743679
22MP0003646_muscle_fatigue2.14232475
23MP0003329_amyloid_beta_deposits2.00665980
24MP0002733_abnormal_thermal_nociception1.89963222
25MP0006072_abnormal_retinal_apoptosis1.88676982
26MP0001529_abnormal_vocalization1.88579566
27MP0008875_abnormal_xenobiotic_pharmacok1.85009242
28MP0001970_abnormal_pain_threshold1.80144948
29MP0002067_abnormal_sensory_capabilities1.76327043
30MP0010386_abnormal_urinary_bladder1.66438820
31MP0001486_abnormal_startle_reflex1.65142253
32MP0001905_abnormal_dopamine_level1.64363065
33MP0000604_amyloidosis1.63271047
34MP0005423_abnormal_somatic_nervous1.62509280
35MP0001984_abnormal_olfaction1.60173851
36MP0002638_abnormal_pupillary_reflex1.59057835
37MP0005386_behavior/neurological_phenoty1.58123259
38MP0004924_abnormal_behavior1.58123259
39MP0008872_abnormal_physiological_respon1.54863395
40MP0004142_abnormal_muscle_tone1.54483168
41MP0005535_abnormal_body_temperature1.53810611
42MP0008260_abnormal_autophagy1.52277758
43MP0008877_abnormal_DNA_methylation1.50803740
44MP0004510_myositis1.46618061
45MP0003879_abnormal_hair_cell1.45372072
46MP0002184_abnormal_innervation1.42346548
47MP0005253_abnormal_eye_physiology1.41511384
48MP0003718_maternal_effect1.39904034
49MP0003787_abnormal_imprinting1.38749390
50MP0005332_abnormal_amino_acid1.36797194
51MP0005187_abnormal_penis_morphology1.36454909
52MP0001188_hyperpigmentation1.35606106
53MP0004858_abnormal_nervous_system1.34869729
54MP0002332_abnormal_exercise_endurance1.34285913
55MP0006082_CNS_inflammation1.33707180
56MP0003806_abnormal_nucleotide_metabolis1.33644335
57MP0002234_abnormal_pharynx_morphology1.33251977
58MP0002909_abnormal_adrenal_gland1.32696240
59MP0003186_abnormal_redox_activity1.30462344
60MP0002876_abnormal_thyroid_physiology1.28442154
61MP0000427_abnormal_hair_cycle1.28066021
62MP0002938_white_spotting1.26874001
63MP0003786_premature_aging1.24440561
64MP0002160_abnormal_reproductive_system1.24010502
65MP0005646_abnormal_pituitary_gland1.22235742
66MP0003011_delayed_dark_adaptation1.21728273
67MP0008058_abnormal_DNA_repair1.20868333
68MP0004885_abnormal_endolymph1.20684667
69MP0002557_abnormal_social/conspecific_i1.19935275
70MP0008775_abnormal_heart_ventricle1.18563562
71MP0005379_endocrine/exocrine_gland_phen1.17771636
72MP0001502_abnormal_circadian_rhythm1.17387410
73MP0005645_abnormal_hypothalamus_physiol1.16325469
74MP0000372_irregular_coat_pigmentation1.16053487
75MP0004811_abnormal_neuron_physiology1.13463417
76MP0003633_abnormal_nervous_system1.13432796
77MP0000749_muscle_degeneration1.12748288
78MP0004145_abnormal_muscle_electrophysio1.12732807
79MP0004085_abnormal_heartbeat1.10853451
80MP0002090_abnormal_vision1.10703958
81MP0002837_dystrophic_cardiac_calcinosis1.09694082
82MP0006035_abnormal_mitochondrial_morpho1.08961615
83MP0001986_abnormal_taste_sensitivity1.08833253
84MP0002066_abnormal_motor_capabilities/c1.08058994
85MP0003690_abnormal_glial_cell1.07023350
86MP0003724_increased_susceptibility_to1.06847442
87MP0009785_altered_susceptibility_to1.06781372
88MP0002163_abnormal_gland_morphology1.05077962
89MP0003137_abnormal_impulse_conducting1.04787958
90MP0008569_lethality_at_weaning1.04107448
91MP0003136_yellow_coat_color1.03932531
92MP0008995_early_reproductive_senescence1.03229973
93MP0003075_altered_response_to1.02620798
94MP0002229_neurodegeneration0.99281001
95MP0000778_abnormal_nervous_system0.97720679
96MP0000647_abnormal_sebaceous_gland0.96668338
97MP0004133_heterotaxia0.96404230
98MP0005084_abnormal_gallbladder_morpholo0.95925866
99MP0005389_reproductive_system_phenotype0.94855790
100MP0003631_nervous_system_phenotype0.94701793
101MP0002277_abnormal_respiratory_mucosa0.93411620
102MP0000751_myopathy0.93384485
103MP0000631_abnormal_neuroendocrine_gland0.93175332
104MP0004742_abnormal_vestibular_system0.91873436
105MP0004484_altered_response_of0.91561421
106MP0005636_abnormal_mineral_homeostasis0.90476847
107MP0004043_abnormal_pH_regulation0.89854617
108MP0001485_abnormal_pinna_reflex0.89846344
109MP0000920_abnormal_myelination0.89779719
110MP0002148_abnormal_hypersensitivity_rea0.89555965
111MP0005058_abnormal_lysosome_morphology0.89305726
112MP0000569_abnormal_digit_pigmentation0.88786673
113MP0004130_abnormal_muscle_cell0.88375000
114MP0005451_abnormal_body_composition0.87899295
115MP0000538_abnormal_urinary_bladder0.87332684
116MP0009764_decreased_sensitivity_to0.87306727
117MP0002882_abnormal_neuron_morphology0.87064665
118MP0005410_abnormal_fertilization0.86836981
119MP0000955_abnormal_spinal_cord0.86748924
120MP0004036_abnormal_muscle_relaxation0.85875930
121MP0005174_abnormal_tail_pigmentation0.83270086
122MP0006292_abnormal_olfactory_placode0.82584369
123MP0001764_abnormal_homeostasis0.82431839
124MP0006036_abnormal_mitochondrial_physio0.81190285
125MP0005367_renal/urinary_system_phenotyp0.80552701
126MP0000516_abnormal_urinary_system0.80552701
127MP0004215_abnormal_myocardial_fiber0.79620398
128MP0003283_abnormal_digestive_organ0.79065493
129MP0010329_abnormal_lipoprotein_level0.79045169
130MP0003303_peritoneal_inflammation0.75531236
131MP0005167_abnormal_blood-brain_barrier0.74197543
132MP0004381_abnormal_hair_follicle0.73631211
133MP0005409_darkened_coat_color0.73252505
134MP0003634_abnormal_glial_cell0.72877186
135MP0003183_abnormal_peptide_metabolism0.72255831
136MP0005166_decreased_susceptibility_to0.71691901
137MP0002139_abnormal_hepatobiliary_system0.71341626
138MP0002069_abnormal_eating/drinking_beha0.70064501
139MP0000013_abnormal_adipose_tissue0.69619099
140MP0005551_abnormal_eye_electrophysiolog0.66787981
141MP0008874_decreased_physiological_sensi0.66377781
142MP0003122_maternal_imprinting0.66280362
143MP0002254_reproductive_system_inflammat0.63166791
144MP0000230_abnormal_systemic_arterial0.62965470
145MP0009780_abnormal_chondrocyte_physiolo0.62028883

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.46807517
2Myokymia (HP:0002411)4.04979261
3Absence seizures (HP:0002121)3.59701596
4Atonic seizures (HP:0010819)3.52882901
5Focal seizures (HP:0007359)3.51639755
6Visual hallucinations (HP:0002367)3.43090248
7Acute necrotizing encephalopathy (HP:0006965)3.36689542
8Febrile seizures (HP:0002373)3.32760625
9Dialeptic seizures (HP:0011146)3.32697879
10Progressive inability to walk (HP:0002505)3.28798563
11Epileptic encephalopathy (HP:0200134)3.25052501
12Pancreatic cysts (HP:0001737)3.20816680
13Generalized tonic-clonic seizures (HP:0002069)3.11819716
14Abnormal mitochondria in muscle tissue (HP:0008316)3.07917163
15Pheochromocytoma (HP:0002666)3.06018286
16Limb dystonia (HP:0002451)3.02262093
17Pancreatic fibrosis (HP:0100732)2.96546686
18True hermaphroditism (HP:0010459)2.88168910
19Neuroendocrine neoplasm (HP:0100634)2.85372211
20Progressive macrocephaly (HP:0004481)2.84647846
21Abnormality of midbrain morphology (HP:0002418)2.84148331
22Molar tooth sign on MRI (HP:0002419)2.84148331
23Hypothermia (HP:0002045)2.82904441
24Acute encephalopathy (HP:0006846)2.82122523
25Methylmalonic acidemia (HP:0002912)2.81830622
26Mutism (HP:0002300)2.81665450
27Supranuclear gaze palsy (HP:0000605)2.79459831
28Nephronophthisis (HP:0000090)2.73835643
29Mitochondrial inheritance (HP:0001427)2.73720645
30Decreased activity of mitochondrial respiratory chain (HP:0008972)2.71675702
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.71675702
32Renal cortical cysts (HP:0000803)2.69029309
33Increased serum lactate (HP:0002151)2.66934005
34Ketoacidosis (HP:0001993)2.64337597
35Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.63319367
36Renal Fanconi syndrome (HP:0001994)2.54940631
373-Methylglutaconic aciduria (HP:0003535)2.53276515
38Type II lissencephaly (HP:0007260)2.51537650
39Hyperventilation (HP:0002883)2.50229461
40Large for gestational age (HP:0001520)2.49543123
41Abnormality of the renal cortex (HP:0011035)2.47249253
42Respiratory failure (HP:0002878)2.43661814
43Methylmalonic aciduria (HP:0012120)2.40005144
44Polyphagia (HP:0002591)2.38237072
45Inability to walk (HP:0002540)2.34319255
46Progressive cerebellar ataxia (HP:0002073)2.32650445
47Pendular nystagmus (HP:0012043)2.32134805
48Retinal dysplasia (HP:0007973)2.32000308
49Anxiety (HP:0000739)2.30030900
50Delusions (HP:0000746)2.28854250
51Hypoglycemic coma (HP:0001325)2.28493285
52Increased CSF lactate (HP:0002490)2.27927189
53Recurrent gram-negative bacterial infections (HP:0005420)2.26745077
54Poor suck (HP:0002033)2.26728026
55Abnormality of the renal medulla (HP:0100957)2.24821246
56Broad-based gait (HP:0002136)2.24398093
57Abnormal eating behavior (HP:0100738)2.23773543
58Neurofibrillary tangles (HP:0002185)2.22655954
59Cerebral hypomyelination (HP:0006808)2.19981085
60Optic disc pallor (HP:0000543)2.19512493
61Increased serum pyruvate (HP:0003542)2.18902215
62Abnormality of urine glucose concentration (HP:0011016)2.18717807
63Glycosuria (HP:0003076)2.18717807
64Congenital stationary night blindness (HP:0007642)2.18174866
65Lethargy (HP:0001254)2.17738420
66Congenital primary aphakia (HP:0007707)2.10747475
67Exercise intolerance (HP:0003546)2.08746657
68Ankle clonus (HP:0011448)2.07182400
69Increased hepatocellular lipid droplets (HP:0006565)2.06973862
70Abnormality of glycolysis (HP:0004366)2.04036167
71CNS demyelination (HP:0007305)2.01904095
72Abnormality of vitamin B metabolism (HP:0004340)2.00975804
73Action tremor (HP:0002345)2.00847486
74Torticollis (HP:0000473)1.99210682
75Generalized aminoaciduria (HP:0002909)1.99110950
76Severe muscular hypotonia (HP:0006829)1.98994205
77Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.98934519
78Sclerocornea (HP:0000647)1.98594750
79Hemiparesis (HP:0001269)1.97154206
80Ketosis (HP:0001946)1.97059046
81Cerebral edema (HP:0002181)1.96134630
82Hepatocellular necrosis (HP:0001404)1.95383471
83Hypoplasia of the fovea (HP:0007750)1.95041353
84Aplasia/Hypoplasia of the fovea (HP:0008060)1.95041353
85Nephrogenic diabetes insipidus (HP:0009806)1.95014842
86Progressive microcephaly (HP:0000253)1.94866301
87Esotropia (HP:0000565)1.94601970
88Lactic acidosis (HP:0003128)1.91983567
89Parakeratosis (HP:0001036)1.88397950
90Stomatitis (HP:0010280)1.88060113
91Attenuation of retinal blood vessels (HP:0007843)1.87120415
92Gait imbalance (HP:0002141)1.87095806
93Abnormality of aromatic amino acid family metabolism (HP:0004338)1.86206683
94Dynein arm defect of respiratory motile cilia (HP:0012255)1.86178406
95Absent/shortened dynein arms (HP:0200106)1.86178406
96Abnormal rod and cone electroretinograms (HP:0008323)1.85947752
97Exertional dyspnea (HP:0002875)1.85826061
98Oligomenorrhea (HP:0000876)1.85308016
99Epileptiform EEG discharges (HP:0011182)1.84346479
100EEG with generalized epileptiform discharges (HP:0011198)1.84043732
101Blue irides (HP:0000635)1.83162139
102Abnormality of renal resorption (HP:0011038)1.83120843
103Furrowed tongue (HP:0000221)1.82684956
104Abnormal hair whorl (HP:0010721)1.82638798
105Medial flaring of the eyebrow (HP:0010747)1.82553785
106Ulnar claw (HP:0001178)1.82088000
107Cerebral hemorrhage (HP:0001342)1.82041160
108Lissencephaly (HP:0001339)1.81783081
109Agitation (HP:0000713)1.81676497
110Increased muscle lipid content (HP:0009058)1.81282305
111Eczematoid dermatitis (HP:0000976)1.81035138
112Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.80734066
113Focal dystonia (HP:0004373)1.80645625
114Psychosis (HP:0000709)1.80568290
115Generalized myoclonic seizures (HP:0002123)1.80444111
116Increased intramyocellular lipid droplets (HP:0012240)1.80339497
117Craniofacial dystonia (HP:0012179)1.80015035
118Congenital, generalized hypertrichosis (HP:0004540)1.79221460
119Abnormality of macrophages (HP:0004311)1.79099022
120Lipid accumulation in hepatocytes (HP:0006561)1.78875770
121Hypokinesia (HP:0002375)1.78691842
122Hypomagnesemia (HP:0002917)1.78322973
123Hypsarrhythmia (HP:0002521)1.78267836
124Hyperinsulinemic hypoglycemia (HP:0000825)1.78055421
125Cystic liver disease (HP:0006706)1.78008798
126Tetraparesis (HP:0002273)1.77120840
127Muscle hypertrophy of the lower extremities (HP:0008968)1.76903212
128Abnormality of the fovea (HP:0000493)1.76265650
129Abnormality of alanine metabolism (HP:0010916)1.76132644
130Hyperalaninemia (HP:0003348)1.76132644
131Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.76132644
132Recurrent abscess formation (HP:0002722)1.75129245
133Abnormal respiratory epithelium morphology (HP:0012253)1.74265939
134Abnormal respiratory motile cilium morphology (HP:0005938)1.74265939
135Dysmetria (HP:0001310)1.73616807
136Gaze-evoked nystagmus (HP:0000640)1.73041893
137Abnormality of the vitamin B12 metabolism (HP:0004341)1.73002222
138Abnormality of the vocal cords (HP:0008777)1.72959612
139Abnormality of calcium-phosphate metabolism (HP:0100530)1.72886142
140Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.72792882
141Recurrent bacterial skin infections (HP:0005406)1.72426984
142Leukodystrophy (HP:0002415)1.72255185
143Cerebral inclusion bodies (HP:0100314)1.72156061
144Congenital ichthyosiform erythroderma (HP:0007431)1.71342774
145Delayed gross motor development (HP:0002194)1.71072476
146Failure to thrive in infancy (HP:0001531)1.70808308
147Depression (HP:0000716)1.70436890
148CNS hypomyelination (HP:0003429)1.70283968
149Polydipsia (HP:0001959)1.69618323
150Abnormal drinking behavior (HP:0030082)1.69618323
151Fetal akinesia sequence (HP:0001989)1.69372481
152X-linked dominant inheritance (HP:0001423)1.68623972
153Muscular hypotonia of the trunk (HP:0008936)1.67778062
154Axonal loss (HP:0003447)1.67464550
155Excessive salivation (HP:0003781)1.67364142
156Drooling (HP:0002307)1.67364142
157Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.66611458
158Increased neuronal autofluorescent lipopigment (HP:0002074)1.65970727
159Status epilepticus (HP:0002133)1.65853141
160Akinesia (HP:0002304)1.65743068
161Hepatic necrosis (HP:0002605)1.65483887

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ARAF4.01876402
2RIPK43.98067397
3FRK3.63992746
4MAP3K93.57782000
5NTRK33.36623834
6CASK2.78863727
7MAP2K72.71279108
8MAP4K22.64546859
9MAP3K122.43041463
10EPHA42.20545340
11MARK12.13455354
12KSR22.09282067
13MINK12.08890010
14EIF2AK32.03018780
15TRIM281.92660097
16MAP2K41.91546273
17MAP3K41.85226910
18NUAK11.83840939
19GRK51.78505958
20CAMKK21.70246517
21ZAK1.68297582
22GRK11.67207514
23PBK1.66418036
24TLK11.63223571
25BCKDK1.59884124
26LIMK11.56407655
27PINK11.55271231
28PLK21.53199614
29BMPR21.49576178
30NTRK11.44859182
31MAP3K131.44690294
32DAPK21.43909848
33CSNK1G31.40564047
34EIF2AK11.39255275
35BUB11.35618685
36VRK21.35198474
37BRAF1.34723427
38GRK71.33059858
39NME11.31777407
40MUSK1.29900724
41ERBB31.24235918
42CDK191.20748911
43BMPR1B1.20517449
44CSNK1G11.18867924
45KSR11.17278599
46TNIK1.13006325
47PAK61.12048372
48PHKG11.09625707
49PHKG21.09625707
50PLK31.09371739
51RAF11.09259948
52CSNK1A1L1.06845228
53PRKCG1.04617647
54NME21.02700876
55CAMK2A1.01778968
56PRKCE1.00983612
57MAPKAPK31.00880228
58ABL21.00071877
59MAP3K10.99670459
60MAPKAPK50.98825894
61STK160.98660574
62MST1R0.98596203
63CCNB10.97816993
64CAMK2G0.93923032
65OXSR10.93851468
66NEK10.93228340
67MAPK130.93202140
68FES0.93152412
69PIM20.92703145
70CDK50.92594746
71MAP3K20.90676443
72VRK10.90604635
73PNCK0.90380528
74SIK30.90298983
75INSRR0.89223005
76TBK10.88435149
77MAP3K50.85740819
78STK390.85397942
79ADRBK20.83389034
80CAMK2B0.83140140
81MYLK0.83032287
82ACVR1B0.80686934
83STK38L0.77900862
84TAOK30.76920403
85CAMKK10.74628729
86PDK20.72696683
87BLK0.72068643
88TESK10.71714833
89CAMK2D0.71370480
90NTRK20.69714209
91TSSK60.68980564
92WNK40.68112150
93DAPK10.66878673
94FGR0.66780534
95IRAK20.64916140
96PLK40.64391799
97MAP2K60.64053240
98WNK30.63887012
99PRKCI0.62016319
100MOS0.60842935
101PAK30.60557528
102BRSK20.58767716
103IRAK30.57943724
104PDK40.57912552
105PDK30.57912552
106MAP2K10.56746103
107DYRK20.56355749
108MKNK20.55601055
109OBSCN0.55563296
110MAP3K140.54087299
111WEE10.54009065
112BCR0.52858889
113ERBB40.52701291
114PDPK10.52552530
115MAP3K60.52223542
116PLK10.51354624
117SIK20.51049742
118CDK140.51020698
119CSNK1G20.48273326
120MATK0.47337813
121CAMK10.47164137
122MAPK150.46033320
123AKT30.45595584
124LATS20.45564257
125ADRBK10.44507332
126MST40.44306244
127MAP3K110.44081338
128CSNK1A10.43185477
129PTK2B0.42867729
130SGK4940.41513242
131SGK2230.41513242
132SYK0.41284043
133PDK10.40830132
134EIF2AK20.40158600
135FER0.39891889
136TAOK10.39539725
137CDK180.39456467
138MARK30.37758040
139BRSK10.36981449
140PKN10.36019438
141STK30.36009375
142PRKACA0.35978877
143FGFR20.35891185
144PRKCA0.34935704
145RPS6KA50.32590891
146PRKACB0.32367553
147SRPK10.30857330
148CSNK1D0.29736848
149PRKG10.29605110

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.60767400
2Nicotine addiction_Homo sapiens_hsa050333.30444039
3Collecting duct acid secretion_Homo sapiens_hsa049663.21901630
4Oxidative phosphorylation_Homo sapiens_hsa001903.13506845
5Parkinsons disease_Homo sapiens_hsa050122.32279304
6Rheumatoid arthritis_Homo sapiens_hsa053232.20364359
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.19885931
8GABAergic synapse_Homo sapiens_hsa047272.17438126
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.15726688
10Alzheimers disease_Homo sapiens_hsa050102.04045544
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03205387
12Olfactory transduction_Homo sapiens_hsa047401.89523565
13Morphine addiction_Homo sapiens_hsa050321.81602379
14Vibrio cholerae infection_Homo sapiens_hsa051101.79962692
15Circadian entrainment_Homo sapiens_hsa047131.78313850
16Long-term potentiation_Homo sapiens_hsa047201.75987225
17Amphetamine addiction_Homo sapiens_hsa050311.73935219
18RNA polymerase_Homo sapiens_hsa030201.70749878
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.69856659
20Type I diabetes mellitus_Homo sapiens_hsa049401.67410198
21Propanoate metabolism_Homo sapiens_hsa006401.66062641
22Serotonergic synapse_Homo sapiens_hsa047261.64581231
23Vitamin B6 metabolism_Homo sapiens_hsa007501.61317142
24Glutamatergic synapse_Homo sapiens_hsa047241.61086382
25Cardiac muscle contraction_Homo sapiens_hsa042601.60982450
26Dopaminergic synapse_Homo sapiens_hsa047281.58965896
27Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.56164738
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.53548438
29Phagosome_Homo sapiens_hsa041451.50756929
30Selenocompound metabolism_Homo sapiens_hsa004501.48816740
31Huntingtons disease_Homo sapiens_hsa050161.48304323
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.46727980
33Taste transduction_Homo sapiens_hsa047421.45061801
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.38723469
35Insulin secretion_Homo sapiens_hsa049111.38043269
36Salivary secretion_Homo sapiens_hsa049701.37081280
37Nitrogen metabolism_Homo sapiens_hsa009101.36398851
38Long-term depression_Homo sapiens_hsa047301.32808098
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27998920
40Basal transcription factors_Homo sapiens_hsa030221.26467882
41Cholinergic synapse_Homo sapiens_hsa047251.26079746
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22433208
43Cocaine addiction_Homo sapiens_hsa050301.21926354
44Sulfur relay system_Homo sapiens_hsa041221.18572224
45Calcium signaling pathway_Homo sapiens_hsa040201.17575725
46Renin secretion_Homo sapiens_hsa049241.17377816
47Graft-versus-host disease_Homo sapiens_hsa053321.16136403
48Tryptophan metabolism_Homo sapiens_hsa003801.15967612
49RNA degradation_Homo sapiens_hsa030181.13527408
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11181084
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.10660539
52Caffeine metabolism_Homo sapiens_hsa002321.10558892
53Gastric acid secretion_Homo sapiens_hsa049711.09970614
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.08553097
55Linoleic acid metabolism_Homo sapiens_hsa005911.05187430
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04517203
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03718348
58African trypanosomiasis_Homo sapiens_hsa051431.02903466
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02858184
60Homologous recombination_Homo sapiens_hsa034401.02550314
61Proteasome_Homo sapiens_hsa030501.02031672
62Circadian rhythm_Homo sapiens_hsa047101.01070700
63Regulation of autophagy_Homo sapiens_hsa041400.98452223
64One carbon pool by folate_Homo sapiens_hsa006700.95289297
65Oxytocin signaling pathway_Homo sapiens_hsa049210.94785873
66Pyruvate metabolism_Homo sapiens_hsa006200.93524859
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92285373
68Fanconi anemia pathway_Homo sapiens_hsa034600.90010010
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89717839
70Prion diseases_Homo sapiens_hsa050200.88134335
71Metabolic pathways_Homo sapiens_hsa011000.86474898
72Purine metabolism_Homo sapiens_hsa002300.84855233
73Tuberculosis_Homo sapiens_hsa051520.83886549
74GnRH signaling pathway_Homo sapiens_hsa049120.83368635
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.83332872
76beta-Alanine metabolism_Homo sapiens_hsa004100.83115128
77Fatty acid elongation_Homo sapiens_hsa000620.82835785
78Pertussis_Homo sapiens_hsa051330.81304236
79Arginine and proline metabolism_Homo sapiens_hsa003300.80783469
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80060247
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78560033
82Salmonella infection_Homo sapiens_hsa051320.77938778
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76740568
84Pyrimidine metabolism_Homo sapiens_hsa002400.76613840
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76595029
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75880624
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73769242
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73668848
89Lysosome_Homo sapiens_hsa041420.72908323
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72836999
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72483345
92Phototransduction_Homo sapiens_hsa047440.72375456
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72102402
94Sphingolipid metabolism_Homo sapiens_hsa006000.72000134
95Chemical carcinogenesis_Homo sapiens_hsa052040.69656199
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68443964
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68161735
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67873302
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66974243
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65606424
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.64945087
102Type II diabetes mellitus_Homo sapiens_hsa049300.64584922
103cAMP signaling pathway_Homo sapiens_hsa040240.63678794
104Nucleotide excision repair_Homo sapiens_hsa034200.62993921
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61893015
106Asthma_Homo sapiens_hsa053100.60712151
107Gap junction_Homo sapiens_hsa045400.59715351
108Dorso-ventral axis formation_Homo sapiens_hsa043200.59227324
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59190524
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58403509
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.58099058
112Glutathione metabolism_Homo sapiens_hsa004800.56635088
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56045309
114Allograft rejection_Homo sapiens_hsa053300.54646597
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.53647738
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.53597245
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51491991
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50489390
119Fatty acid metabolism_Homo sapiens_hsa012120.49574396
120Folate biosynthesis_Homo sapiens_hsa007900.49529388
121Ether lipid metabolism_Homo sapiens_hsa005650.49143773
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48194428
123Sulfur metabolism_Homo sapiens_hsa009200.47249799
124Retinol metabolism_Homo sapiens_hsa008300.47085406
125Fatty acid degradation_Homo sapiens_hsa000710.46383399
126Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46191217
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45335361
128Butanoate metabolism_Homo sapiens_hsa006500.44745339
129Mineral absorption_Homo sapiens_hsa049780.43182369
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.43074012
131RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43014111
132Primary bile acid biosynthesis_Homo sapiens_hsa001200.42916395
133Pancreatic secretion_Homo sapiens_hsa049720.42283777
134Phenylalanine metabolism_Homo sapiens_hsa003600.41937753
135Legionellosis_Homo sapiens_hsa051340.41743061
136Mismatch repair_Homo sapiens_hsa034300.41268777
137Leishmaniasis_Homo sapiens_hsa051400.41249703
138RNA transport_Homo sapiens_hsa030130.41168091
139Ribosome_Homo sapiens_hsa030100.39675968
140Non-homologous end-joining_Homo sapiens_hsa034500.38963977
141Arginine biosynthesis_Homo sapiens_hsa002200.37481718
142Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35830918
143Estrogen signaling pathway_Homo sapiens_hsa049150.35473749
144Staphylococcus aureus infection_Homo sapiens_hsa051500.34753052
145cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33953827
146Steroid biosynthesis_Homo sapiens_hsa001000.32869316
147Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.32650958
148Peroxisome_Homo sapiens_hsa041460.32480129
149ErbB signaling pathway_Homo sapiens_hsa040120.30625653
150Osteoclast differentiation_Homo sapiens_hsa043800.29849297
151Protein export_Homo sapiens_hsa030600.29237724
152Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27638461

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