SPSB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)4.88514541
2central nervous system myelination (GO:0022010)4.82834611
3axon ensheathment in central nervous system (GO:0032291)4.82834611
4virion attachment to host cell (GO:0019062)4.72960384
5adhesion of symbiont to host cell (GO:0044650)4.72960384
6regulation of vitamin metabolic process (GO:0030656)4.24344170
7adhesion of symbiont to host (GO:0044406)3.99954923
8positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.97502768
9regulation of membrane protein ectodomain proteolysis (GO:0051043)3.90073201
10ensheathment of neurons (GO:0007272)3.81779774
11axon ensheathment (GO:0008366)3.81779774
12myelination (GO:0042552)3.78930462
13low-density lipoprotein particle clearance (GO:0034383)3.70834977
14negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.62429582
15cell adhesion mediated by integrin (GO:0033627)3.59787721
16regulation of cytokine secretion involved in immune response (GO:0002739)3.42673294
17cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.36650901
18collagen fibril organization (GO:0030199)3.31095489
19glycosphingolipid catabolic process (GO:0046479)3.29835856
20regulation of cholesterol storage (GO:0010885)3.24231373
21activation of MAPKKK activity (GO:0000185)3.22665322
22positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.22280323
23branching involved in labyrinthine layer morphogenesis (GO:0060670)3.19359583
24peripheral nervous system axon ensheathment (GO:0032292)3.16495386
25myelination in peripheral nervous system (GO:0022011)3.16495386
26positive regulation of chemokine biosynthetic process (GO:0045080)3.15343626
27regulation of mononuclear cell migration (GO:0071675)3.10919815
28growth hormone receptor signaling pathway (GO:0060396)3.08291070
29creatine metabolic process (GO:0006600)3.07246960
30regulation of chronic inflammatory response (GO:0002676)3.06719602
31negative regulation of lipid storage (GO:0010888)3.05782545
32negative regulation of nitric oxide biosynthetic process (GO:0045019)3.05524968
33positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.03756576
34myelin maintenance (GO:0043217)3.01685686
35glycolipid catabolic process (GO:0019377)3.01130845
36regulation of heterotypic cell-cell adhesion (GO:0034114)2.97746529
37regulation of T-helper 1 cell differentiation (GO:0045625)2.97311469
38regulation of chemokine biosynthetic process (GO:0045073)2.95914449
39positive regulation of heat generation (GO:0031652)2.94742661
40positive regulation of extracellular matrix organization (GO:1903055)2.94699228
41cellular response to growth hormone stimulus (GO:0071378)2.93995003
42lipopolysaccharide-mediated signaling pathway (GO:0031663)2.93107393
43regulation of fever generation (GO:0031620)2.91695382
44oligosaccharide catabolic process (GO:0009313)2.91461862
45regulation of podosome assembly (GO:0071801)2.87551501
46positive regulation of endothelial cell apoptotic process (GO:2000353)2.85293461
47barbed-end actin filament capping (GO:0051016)2.84644058
48regulation of extracellular matrix disassembly (GO:0010715)2.82992936
49negative regulation of protein localization to cell surface (GO:2000009)2.80849036
50fibrinolysis (GO:0042730)2.80418293
51decidualization (GO:0046697)2.77427376
52cellular response to thyroid hormone stimulus (GO:0097067)2.75946488
53keratan sulfate catabolic process (GO:0042340)2.75815419
54membrane raft organization (GO:0031579)2.73588850
55regulation of nitric oxide biosynthetic process (GO:0045428)2.67274825
56chondrocyte development (GO:0002063)2.64742307
57cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.63253779
58protein heterotrimerization (GO:0070208)2.61928419
59skin morphogenesis (GO:0043589)2.61893615
60regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.60817800
61myeloid dendritic cell differentiation (GO:0043011)2.59632786
62oligodendrocyte differentiation (GO:0048709)2.59577954
63extracellular matrix assembly (GO:0085029)2.59241900
64dermatan sulfate biosynthetic process (GO:0030208)2.58522883
65NIK/NF-kappaB signaling (GO:0038061)2.57673558
66substrate-dependent cell migration (GO:0006929)2.57273470
67type I interferon signaling pathway (GO:0060337)2.56276347
68cellular response to type I interferon (GO:0071357)2.56276347
69ceramide catabolic process (GO:0046514)2.56156990
70germinal center formation (GO:0002467)2.54421708
71response to type I interferon (GO:0034340)2.54241724
72extracellular fibril organization (GO:0043206)2.54043676
73retina vasculature morphogenesis in camera-type eye (GO:0061299)2.53902043
74glomerular filtration (GO:0003094)2.53879278
75response to peptidoglycan (GO:0032494)2.53155530
76eye photoreceptor cell differentiation (GO:0001754)2.53111209
77photoreceptor cell differentiation (GO:0046530)2.53111209
78response to lipoprotein particle (GO:0055094)2.52644774
79positive regulation of nitric oxide biosynthetic process (GO:0045429)2.52417352
80negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.50413341
81astrocyte development (GO:0014002)2.47390035
82negative regulation of interleukin-12 production (GO:0032695)2.46832486
83positive regulation of actin filament depolymerization (GO:0030836)2.46783271
84limb bud formation (GO:0060174)2.46766652
85endothelial cell morphogenesis (GO:0001886)2.46478572
86estrogen biosynthetic process (GO:0006703)2.46328945
87cellular response to epinephrine stimulus (GO:0071872)2.45768909
88response to thyroid hormone (GO:0097066)2.45216160
89protein localization to endosome (GO:0036010)2.44971417
90negative regulation of cytokine production involved in immune response (GO:0002719)2.43323303
91response to follicle-stimulating hormone (GO:0032354)2.42855465
92actin filament depolymerization (GO:0030042)2.42846189
93branching involved in salivary gland morphogenesis (GO:0060445)2.42679694
94response to laminar fluid shear stress (GO:0034616)2.42188127
95membrane lipid catabolic process (GO:0046466)2.41155198
96positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.40829444
97positive regulation of astrocyte differentiation (GO:0048711)2.40266053
98cartilage condensation (GO:0001502)2.40035840
99cell aggregation (GO:0098743)2.40035840
100renal filtration (GO:0097205)2.38778398
101plasma lipoprotein particle clearance (GO:0034381)2.37863035
102regulation of early endosome to late endosome transport (GO:2000641)2.37738825
103endocytic recycling (GO:0032456)2.37427836
104apoptotic cell clearance (GO:0043277)2.37362337
105bone trabecula formation (GO:0060346)2.35588337
106negative regulation of neurotransmitter secretion (GO:0046929)2.33364979
107pinocytosis (GO:0006907)2.32279196
108platelet-derived growth factor receptor signaling pathway (GO:0048008)2.32115851
109negative regulation of fibrinolysis (GO:0051918)2.31466427
110dermatan sulfate metabolic process (GO:0030205)2.31281385
111sphingolipid catabolic process (GO:0030149)2.30312656
112cortical actin cytoskeleton organization (GO:0030866)2.29328726
113positive regulation of p38MAPK cascade (GO:1900745)2.28954984
114chondrocyte proliferation (GO:0035988)2.28563046
115leukocyte migration involved in inflammatory response (GO:0002523)2.28435366
116protein targeting to plasma membrane (GO:0072661)2.28405864
117regulation of p38MAPK cascade (GO:1900744)2.28292205
118peptidyl-tyrosine autophosphorylation (GO:0038083)2.27082783
119monocyte chemotaxis (GO:0002548)2.26849535
120response to redox state (GO:0051775)2.26570982
121positive regulation of lipid storage (GO:0010884)2.25356926
122collagen catabolic process (GO:0030574)2.24139591
123cyclooxygenase pathway (GO:0019371)2.23373759
124regulation of chemokine-mediated signaling pathway (GO:0070099)2.23140052
125ovulation from ovarian follicle (GO:0001542)2.22464829
126regulation of immunoglobulin secretion (GO:0051023)2.22204966
127astrocyte differentiation (GO:0048708)2.21673787
128positive regulation of protein kinase C signaling (GO:0090037)2.21097690
129acute-phase response (GO:0006953)2.20661527
130interleukin-6-mediated signaling pathway (GO:0070102)2.20388341
131collagen metabolic process (GO:0032963)2.19771648
132regulation of macrophage cytokine production (GO:0010935)2.19732232
133positive regulation of fat cell differentiation (GO:0045600)2.19611943
134glial cell migration (GO:0008347)2.19444587
135desmosome organization (GO:0002934)2.18456210
136regulation of plasminogen activation (GO:0010755)2.18057807
137hemidesmosome assembly (GO:0031581)2.18023514
138dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.17916533
139cellular response to catecholamine stimulus (GO:0071870)2.17833381
140cellular response to monoamine stimulus (GO:0071868)2.17833381
141basement membrane organization (GO:0071711)2.17561943
142positive regulation of natural killer cell differentiation (GO:0032825)2.17372844
143cellular response to lipopolysaccharide (GO:0071222)2.17024819
144fat-soluble vitamin biosynthetic process (GO:0042362)2.16181100
145response to progesterone (GO:0032570)2.15761984
146cortical cytoskeleton organization (GO:0030865)2.15175336
147negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.14446720
148positive regulation of cholesterol efflux (GO:0010875)2.13592195
149ovulation (GO:0030728)2.13476039
150negative regulation of hemostasis (GO:1900047)2.13473668
151negative regulation of blood coagulation (GO:0030195)2.13473668
152epithelial cell-cell adhesion (GO:0090136)2.13080408
153regulation of apoptotic process involved in morphogenesis (GO:1902337)2.12851112
154hyaluronan catabolic process (GO:0030214)2.12744609
155regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.12541305
156positive regulation of type 2 immune response (GO:0002830)2.12283751
157modulation by symbiont of host cellular process (GO:0044068)2.11960096
158regulation of interferon-alpha production (GO:0032647)2.11908184
159pathway-restricted SMAD protein phosphorylation (GO:0060389)2.11790694
160fibril organization (GO:0097435)2.11768219
161regulation of lipid storage (GO:0010883)2.11659130
162positive regulation of osteoblast proliferation (GO:0033690)2.10021348
163positive regulation of glial cell differentiation (GO:0045687)2.09777310
164asymmetric protein localization (GO:0008105)2.09188172
165multicellular organismal catabolic process (GO:0044243)2.08517439
166Rap protein signal transduction (GO:0032486)2.08345705
167myelin assembly (GO:0032288)2.07820719
168regulation of T-helper 2 cell differentiation (GO:0045628)2.07773754
169multicellular organismal macromolecule metabolic process (GO:0044259)2.07750980
170response to epinephrine (GO:0071871)2.07628682
171regulation of cardiac muscle cell contraction (GO:0086004)2.07145799
172plasma membrane repair (GO:0001778)2.06930204
173extracellular matrix organization (GO:0030198)2.06331869
174extracellular structure organization (GO:0043062)2.05435160
175response to catecholamine (GO:0071869)2.05249518
176response to monoamine (GO:0071867)2.05249518
177regulation of T cell tolerance induction (GO:0002664)2.03854924
178positive regulation of smooth muscle cell migration (GO:0014911)2.03069513
179negative regulation of inclusion body assembly (GO:0090084)2.01866329
180stress fiber assembly (GO:0043149)2.01832500
181amino acid import (GO:0043090)2.01066760
182fatty acid elongation (GO:0030497)2.01062456
183import into cell (GO:0098657)1.99059102
184membrane protein ectodomain proteolysis (GO:0006509)1.98576891
185endodermal cell differentiation (GO:0035987)1.98412824
186negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)1.97952560
187glomerular basement membrane development (GO:0032836)1.97761276

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.03285308
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.46642706
3NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.76030330
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.29474024
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.26849805
6* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.23284050
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.17681448
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.15529831
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.14468061
10* ELK3_25401928_ChIP-Seq_HUVEC_Human2.12349126
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.09036281
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.99728196
13CDX2_19796622_ChIP-Seq_MESCs_Mouse1.94707044
14ESR2_21235772_ChIP-Seq_MCF-7_Human1.92778067
15RXR_22158963_ChIP-Seq_LIVER_Mouse1.92757663
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92054263
17EGR1_19374776_ChIP-ChIP_THP-1_Human1.91056212
18RARG_19884340_ChIP-ChIP_MEFs_Mouse1.89670724
19* EP300_21415370_ChIP-Seq_HL-1_Mouse1.89012408
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.86372782
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83812065
22* LXR_22292898_ChIP-Seq_THP-1_Human1.81651301
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.75751811
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.75627511
25IRF8_27001747_Chip-Seq_BMDM_Mouse1.74289148
26AR_21572438_ChIP-Seq_LNCaP_Human1.72351529
27* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.71406371
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.70219056
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.69655979
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.67365626
31* RACK7_27058665_Chip-Seq_MCF-7_Human1.67308939
32IRF8_21731497_ChIP-ChIP_J774_Mouse1.66742345
33* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.65407215
34* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.65407215
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.65224374
36CJUN_26792858_Chip-Seq_BT549_Human1.64825052
37* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.61015036
38EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.60635226
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.60284754
40WT1_19549856_ChIP-ChIP_CCG9911_Human1.59029125
41PPARA_22158963_ChIP-Seq_LIVER_Mouse1.58564547
42LXR_22158963_ChIP-Seq_LIVER_Mouse1.56930726
43SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.56392537
44* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.53885708
45NRF2_20460467_ChIP-Seq_MEFs_Mouse1.53675120
46NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.53675120
47* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52412002
48* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.51042753
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.50706078
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.50580468
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.49819537
52* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.49530943
53SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.48799412
54SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.48799412
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.46309708
56* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42234141
57DROSHA_22980978_ChIP-Seq_HELA_Human1.41455775
58ZNF263_19887448_ChIP-Seq_K562_Human1.41326405
59TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38489033
60GATA2_21666600_ChIP-Seq_HMVEC_Human1.36816197
61RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.32988745
62EZH2_27304074_Chip-Seq_ESCs_Mouse1.31308192
63JARID2_20075857_ChIP-Seq_MESCs_Mouse1.31076758
64EZH2_27294783_Chip-Seq_ESCs_Mouse1.30690331
65BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30444912
66WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30317088
67ESR1_21235772_ChIP-Seq_MCF-7_Human1.29352417
68* TBX20_22328084_ChIP-Seq_HEART_Mouse1.29180683
69* TBX20_22080862_ChIP-Seq_HEART_Mouse1.29180683
70* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28939438
71FOXO3_23340844_ChIP-Seq_DLD1_Human1.28661509
72P63_26484246_Chip-Seq_KERATINOCYTES_Human1.28249530
73CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.27466086
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26903816
75SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26812290
76* UBF1/2_26484160_Chip-Seq_HMECs_Human1.26598429
77JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26377632
78RNF2_27304074_Chip-Seq_ESCs_Mouse1.23691971
79STAT4_19710469_ChIP-ChIP_TH1__Mouse1.22748410
80* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22213684
81* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21904805
82SOX2_20726797_ChIP-Seq_SW620_Human1.20984582
83NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.20553491
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19175156
85* CLOCK_20551151_ChIP-Seq_293T_Human1.18634596
86* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17357264
87HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15687128
88* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.15107244
89JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14658955
90* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13950462
91* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.13617938
92* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.12396595
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11853583
94ATF3_27146783_Chip-Seq_COLON_Human1.11555279
95* TCF7_22412390_ChIP-Seq_EML_Mouse1.11421295
96* VDR_24787735_ChIP-Seq_THP-1_Human1.11410595
97* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10228061
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10148228
99PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10015815
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09306655
101SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.09038481
102* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08794803
103* VDR_21846776_ChIP-Seq_THP-1_Human1.07684909
104* VDR_24763502_ChIP-Seq_THP-1_Human1.06131410
105NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06047554
106PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05835510
107SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05808293
108* KDM2B_26808549_Chip-Seq_DND41_Human1.05647679
109TP53_16413492_ChIP-PET_HCT116_Human1.03847769
110CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02835784
111TP53_18474530_ChIP-ChIP_U2OS_Human1.02722041
112STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.99001394
113* KDM2B_26808549_Chip-Seq_K562_Human0.98987379
114TP53_22127205_ChIP-Seq_IMR90_Human0.98141830
115CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96174242
116RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94752357
117STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94161832
118* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93955930
119SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93353203
120AHR_22903824_ChIP-Seq_MCF-7_Human0.93299080
121NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.93254245
122STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93184035
123CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93097138
124GATA1_19941826_ChIP-Seq_K562_Human0.93085740
125* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92226425
126* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91717984
127SMAD3_21741376_ChIP-Seq_HESCs_Human0.91570982
128* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90654326
129NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90367482
130* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90201265
131MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.89621302
132PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89547391
133ESR1_20079471_ChIP-ChIP_T-47D_Human0.89289971
134ERG_21242973_ChIP-ChIP_JURKAT_Human0.89242929
135GBX2_23144817_ChIP-Seq_PC3_Human0.88562879
136EZH2_22144423_ChIP-Seq_EOC_Human0.88560170
137RUNX1_27514584_Chip-Seq_MCF-7_Human0.87182313
138* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.86634473
139PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86293761
140CDX2_20551321_ChIP-Seq_CACO-2_Human0.86204627
141TP63_23658742_ChIP-Seq_EP156T_Human0.85980830
142* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.85464496
143TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85442806
144RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.84863434
145SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84828514
146TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84241702
147BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84227448
148* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83730958
149NFIB_24661679_ChIP-Seq_LUNG_Mouse0.83605119
150ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82973299
151* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82435521
152CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81700241
153EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.81424090
154PIAS1_25552417_ChIP-Seq_VCAP_Human0.81291902
155SMAD3_21741376_ChIP-Seq_EPCs_Human0.81056039
156RUNX_20019798_ChIP-Seq_JUKART_Human0.80952605
157ER_23166858_ChIP-Seq_MCF-7_Human0.80351939
158RING1B_27294783_Chip-Seq_ESCs_Mouse0.79503116
159* SMAD4_21741376_ChIP-Seq_HESCs_Human0.79411701
160* TP53_23651856_ChIP-Seq_MEFs_Mouse0.79224483
161* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.78749496
162TP53_20018659_ChIP-ChIP_R1E_Mouse0.78011886
163ARNT_22903824_ChIP-Seq_MCF-7_Human0.77865326

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.83482971
2MP0003303_peritoneal_inflammation4.12197671
3MP0009840_abnormal_foam_cell3.62243178
4MP0005503_abnormal_tendon_morphology3.53123831
5MP0005623_abnormal_meninges_morphology3.28694318
6MP0002139_abnormal_hepatobiliary_system3.28150417
7MP0005275_abnormal_skin_tensile2.77392949
8MP0000920_abnormal_myelination2.66753224
9MP0003279_aneurysm2.62185179
10MP0003300_gastrointestinal_ulcer2.61059347
11MP0003950_abnormal_plasma_membrane2.41048734
12MP0005451_abnormal_body_composition2.40631386
13MP0004272_abnormal_basement_membrane2.39323503
14MP0003724_increased_susceptibility_to2.36713931
15MP0006082_CNS_inflammation2.36603377
16MP0003453_abnormal_keratinocyte_physiol2.25276873
17MP0004134_abnormal_chest_morphology2.24905251
18MP0001348_abnormal_lacrimal_gland2.22660479
19MP0003436_decreased_susceptibility_to2.21792846
20MP0003091_abnormal_cell_migration2.14752686
21MP0001958_emphysema2.14655823
22MP0004510_myositis2.09890068
23MP0003191_abnormal_cellular_cholesterol2.02152621
24MP0002148_abnormal_hypersensitivity_rea1.96747147
25MP0002933_joint_inflammation1.93685514
26MP0000751_myopathy1.91108005
27MP0002295_abnormal_pulmonary_circulatio1.90749214
28MP0008004_abnormal_stomach_pH1.88274380
29MP0004947_skin_inflammation1.86932761
30MP0003075_altered_response_to1.85922398
31MP0009384_cardiac_valve_regurgitation1.85897767
32MP0009785_altered_susceptibility_to1.80104513
33MP0004858_abnormal_nervous_system1.72831807
34MP0001299_abnormal_eye_distance/1.72044347
35MP0003566_abnormal_cell_adhesion1.71991038
36MP0009250_abnormal_appendicular_skeleto1.70778568
37MP0009780_abnormal_chondrocyte_physiolo1.68189171
38MP0000013_abnormal_adipose_tissue1.66975003
39MP0000749_muscle_degeneration1.66549377
40MP0002108_abnormal_muscle_morphology1.63910597
41MP0002332_abnormal_exercise_endurance1.63149863
42MP0002837_dystrophic_cardiac_calcinosis1.62451360
43MP0005508_abnormal_skeleton_morphology1.57938056
44MP0003634_abnormal_glial_cell1.48448229
45MP0003329_amyloid_beta_deposits1.46005174
46MP0000858_altered_metastatic_potential1.44895210
47MP0003448_altered_tumor_morphology1.44624295
48MP0003690_abnormal_glial_cell1.44487830
49MP0002254_reproductive_system_inflammat1.43922743
50MP0001542_abnormal_bone_strength1.43289243
51MP0004084_abnormal_cardiac_muscle1.42286863
52MP0010352_gastrointestinal_tract_polyps1.40417730
53MP0005171_absent_coat_pigmentation1.39920542
54MP0009764_decreased_sensitivity_to1.39125507
55MP0003705_abnormal_hypodermis_morpholog1.38993037
56MP0003045_fibrosis1.38210888
57MP0005165_increased_susceptibility_to1.37856242
58MP0005410_abnormal_fertilization1.37193930
59MP0002419_abnormal_innate_immunity1.35607543
60MP0002998_abnormal_bone_remodeling1.34778696
61MP0005387_immune_system_phenotype1.33505572
62MP0001790_abnormal_immune_system1.33505572
63MP0000733_abnormal_muscle_development1.33477974
64MP0005000_abnormal_immune_tolerance1.32298290
65MP0004036_abnormal_muscle_relaxation1.30648281
66MP0005166_decreased_susceptibility_to1.25276524
67MP0005167_abnormal_blood-brain_barrier1.23611776
68MP0000163_abnormal_cartilage_morphology1.23576441
69MP0000750_abnormal_muscle_regeneration1.23257195
70MP0001853_heart_inflammation1.23235636
71MP0000604_amyloidosis1.21544089
72MP0005025_abnormal_response_to1.20232223
73MP0004185_abnormal_adipocyte_glucose1.18309379
74MP0001533_abnormal_skeleton_physiology1.17951435
75MP0000767_abnormal_smooth_muscle1.17924432
76MP0004145_abnormal_muscle_electrophysio1.17638425
77MP0005076_abnormal_cell_differentiation1.17362113
78MP0010155_abnormal_intestine_physiology1.16814296
79MP0002138_abnormal_hepatobiliary_system1.14721621
80MP0005365_abnormal_bile_salt1.14465972
81MP0002282_abnormal_trachea_morphology1.14438145
82MP0004087_abnormal_muscle_fiber1.13955445
83MP0002163_abnormal_gland_morphology1.13008427
84MP0001849_ear_inflammation1.12820604
85MP0005023_abnormal_wound_healing1.12282402
86MP0002896_abnormal_bone_mineralization1.12103626
87MP0005058_abnormal_lysosome_morphology1.11668412
88MP0000003_abnormal_adipose_tissue1.10541473
89MP0005390_skeleton_phenotype1.10046101
90MP0006138_congestive_heart_failure1.09323324
91MP0004742_abnormal_vestibular_system1.06955257
92MP0005360_urolithiasis1.06851410
93MP0008775_abnormal_heart_ventricle1.05396020
94MP0005330_cardiomyopathy1.05351773
95MP0005369_muscle_phenotype1.04980364
96MP0002972_abnormal_cardiac_muscle1.03971222
97MP0008469_abnormal_protein_level1.03602264
98MP0002115_abnormal_skeleton_extremities1.03280730
99MP0005375_adipose_tissue_phenotype1.00815345
100MP0001845_abnormal_inflammatory_respons1.00496904
101MP0000759_abnormal_skeletal_muscle1.00086054
102MP0000747_muscle_weakness0.97818983
103MP0002877_abnormal_melanocyte_morpholog0.97585147
104MP0002796_impaired_skin_barrier0.97474109
105MP0000462_abnormal_digestive_system0.97266204
106MP0001879_abnormal_lymphatic_vessel0.96413676
107MP0005257_abnormal_intraocular_pressure0.95404679
108MP0001661_extended_life_span0.95326453
109MP0000249_abnormal_blood_vessel0.94764391
110MP0005379_endocrine/exocrine_gland_phen0.94496734
111MP0002106_abnormal_muscle_physiology0.94246247
112MP0010234_abnormal_vibrissa_follicle0.93468866
113MP0001346_abnormal_lacrimal_gland0.91967105
114MP0001835_abnormal_antigen_presentation0.91623123
115MP0002060_abnormal_skin_morphology0.91220281
116MP0003385_abnormal_body_wall0.90195199
117MP0005620_abnormal_muscle_contractility0.89410814
118MP0002909_abnormal_adrenal_gland0.88173115
119MP0001216_abnormal_epidermal_layer0.87812311
120MP0002452_abnormal_antigen_presenting0.87779598
121MP0003828_pulmonary_edema0.86321181
122MP0009333_abnormal_splenocyte_physiolog0.86200865
123MP0000343_altered_response_to0.85958798
124MP0009278_abnormal_bone_marrow0.85411767
125MP0005164_abnormal_response_to0.85306055
126MP0002113_abnormal_skeleton_development0.84803809
127MP0000685_abnormal_immune_system0.84525621
128MP0006054_spinal_hemorrhage0.84068805
129MP0004270_analgesia0.82551483
130MP0005666_abnormal_adipose_tissue0.82434220
131MP0001851_eye_inflammation0.80755252
132MP0003868_abnormal_feces_composition0.79979945
133MP0002723_abnormal_immune_serum0.79416895
134MP0003195_calcinosis0.78982073
135MP0004883_abnormal_blood_vessel0.78655301
136MP0000762_abnormal_tongue_morphology0.78638027
137MP0001243_abnormal_dermal_layer0.78531168
138MP0003795_abnormal_bone_structure0.77759573
139MP0010368_abnormal_lymphatic_system0.77323407
140MP0002168_other_aberrant_phenotype0.76383454
141MP0004885_abnormal_endolymph0.76253908
142MP0005464_abnormal_platelet_physiology0.74830210
143MP0002269_muscular_atrophy0.74736188
144MP0005670_abnormal_white_adipose0.74551880
145MP0003172_abnormal_lysosome_physiology0.74483339
146MP0002405_respiratory_system_inflammati0.73142599
147MP0009763_increased_sensitivity_to0.72761153
148MP0004233_abnormal_muscle_weight0.72207141
149MP0005595_abnormal_vascular_smooth0.69315865
150MP0000678_abnormal_parathyroid_gland0.68702852
151MP0005388_respiratory_system_phenotype0.68052393
152MP0002133_abnormal_respiratory_system0.68052393
153MP0005385_cardiovascular_system_phenoty0.66503270
154MP0001544_abnormal_cardiovascular_syste0.66503270
155MP0001485_abnormal_pinna_reflex0.65087257

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)5.39500676
2Abnormality of glycosphingolipid metabolism (HP:0004343)5.39500676
3Abnormality of glycolipid metabolism (HP:0010969)5.39500676
4Premature rupture of membranes (HP:0001788)5.23908894
5Epiphyseal dysplasia (HP:0002656)4.28348923
6Systemic lupus erythematosus (HP:0002725)4.16248435
7Hypoplastic ischia (HP:0003175)3.69888973
8Dysostosis multiplex (HP:0000943)3.69140138
9Muscle fiber splitting (HP:0003555)3.60249319
10Nuclear cataract (HP:0100018)3.53783129
11Neurofibrillary tangles (HP:0002185)3.45790764
12Hyporeflexia of lower limbs (HP:0002600)3.37119883
13Loss of speech (HP:0002371)3.35602967
14Protrusio acetabuli (HP:0003179)3.35223209
15Abnormality of the ischium (HP:0003174)3.23206224
16Myocardial infarction (HP:0001658)3.22023012
17Vacuolated lymphocytes (HP:0001922)3.18097423
18Aortic dissection (HP:0002647)3.11070868
19Abnormality of mucopolysaccharide metabolism (HP:0011020)3.07524380
20Abnormality of polysaccharide metabolism (HP:0011012)3.07524380
21Abnormality of glycosaminoglycan metabolism (HP:0004371)3.07524380
22Broad metatarsal (HP:0001783)3.06805682
23Cupped ribs (HP:0000887)3.03745501
24Complement deficiency (HP:0004431)3.02461834
25Urinary glycosaminoglycan excretion (HP:0003541)3.02454827
26Mucopolysacchariduria (HP:0008155)3.02454827
27Axonal loss (HP:0003447)3.00126758
28Vascular tortuosity (HP:0004948)2.96671756
29Small epiphyses (HP:0010585)2.92288100
30Irregular epiphyses (HP:0010582)2.91924635
31Arterial tortuosity (HP:0005116)2.91906774
32Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.90865354
33Increased cerebral lipofuscin (HP:0011813)2.84200107
34Abnormality of complement system (HP:0005339)2.83279286
35Interstitial pulmonary disease (HP:0006530)2.76357417
36Glomerulonephritis (HP:0000099)2.70333009
37Cervical subluxation (HP:0003308)2.68726691
38Shallow orbits (HP:0000586)2.60851357
39Neonatal short-limb short stature (HP:0008921)2.60361609
40Abnormality of monocarboxylic acid metabolism (HP:0010996)2.59939919
41Wormian bones (HP:0002645)2.58079789
42Scapular winging (HP:0003691)2.51725658
43Vitreoretinal degeneration (HP:0000655)2.50823247
44Cerebral aneurysm (HP:0004944)2.50000715
45Asymmetric septal hypertrophy (HP:0001670)2.49974235
46Cerebral inclusion bodies (HP:0100314)2.48932084
47Spondylolisthesis (HP:0003302)2.47574628
48Vertebral compression fractures (HP:0002953)2.47517270
49Abnormality of macrophages (HP:0004311)2.47297366
50Aortic aneurysm (HP:0004942)2.44300713
51Soft skin (HP:0000977)2.43973356
52Abnormality of dentin (HP:0010299)2.42928435
53Hydroxyprolinuria (HP:0003080)2.41518574
54Abnormality of proline metabolism (HP:0010907)2.41518574
55Deep venous thrombosis (HP:0002625)2.40784420
56Spinal rigidity (HP:0003306)2.39822971
57Osteoarthritis (HP:0002758)2.39070709
58Increased connective tissue (HP:0009025)2.38455334
59Bell-shaped thorax (HP:0001591)2.34242083
60Amyloidosis (HP:0011034)2.33747974
61Orchitis (HP:0100796)2.32674147
62Supranuclear gaze palsy (HP:0000605)2.29229486
63Abnormality of the nasal mucosa (HP:0000433)2.27810844
64Malnutrition (HP:0004395)2.27211176
65Ulnar bowing (HP:0003031)2.25159792
66Abnormality of the calf musculature (HP:0001430)2.25132493
67Distal lower limb muscle weakness (HP:0009053)2.24947494
68Mitral stenosis (HP:0001718)2.24760972
69Flat acetabular roof (HP:0003180)2.24056990
70Abnormality of the Achilles tendon (HP:0005109)2.23658501
71Ovoid vertebral bodies (HP:0003300)2.21351671
72Aplasia involving bones of the upper limbs (HP:0009823)2.21251576
73Aplasia of the phalanges of the hand (HP:0009802)2.21251576
74Aplasia involving bones of the extremities (HP:0009825)2.21251576
75Esophageal varix (HP:0002040)2.20891148
76Achilles tendon contracture (HP:0001771)2.20130500
77Thin bony cortex (HP:0002753)2.20094719
78Increased variability in muscle fiber diameter (HP:0003557)2.17989801
79Peritonitis (HP:0002586)2.17092101
80Atrophic scars (HP:0001075)2.17063323
81Difficulty running (HP:0009046)2.14265878
82Purpura (HP:0000979)2.13164794
83Hypoplasia of the iris (HP:0007676)2.12671981
84Delayed epiphyseal ossification (HP:0002663)2.10812295
85Mild short stature (HP:0003502)2.10719895
86Platyspondyly (HP:0000926)2.10208325
87Abnormality of the vertebral endplates (HP:0005106)2.09675533
88Abnormal vertebral ossification (HP:0100569)2.08920873
89Blue sclerae (HP:0000592)2.07966134
90Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.07780400
91Degeneration of the lateral corticospinal tracts (HP:0002314)2.07780400
92Sensory axonal neuropathy (HP:0003390)2.07423157
93Round ear (HP:0100830)2.07063259
94Increased neuronal autofluorescent lipopigment (HP:0002074)2.06658100
95Persistence of primary teeth (HP:0006335)2.06524999
96Fragile skin (HP:0001030)2.06065394
97Onion bulb formation (HP:0003383)2.05950647
98Coxa vara (HP:0002812)2.03120429
99Disinhibition (HP:0000734)2.02699691
100Xanthomatosis (HP:0000991)2.02688658
101Metaphyseal cupping (HP:0003021)2.01553180
102Limited hip movement (HP:0008800)2.00574923
103Nephritis (HP:0000123)2.00335428
104Flat capital femoral epiphysis (HP:0003370)1.99478941
105Apathy (HP:0000741)1.99291597
106EMG: myopathic abnormalities (HP:0003458)1.98999701
107Overgrowth (HP:0001548)1.98676446
108Myositis (HP:0100614)1.98563134
109Osteolytic defects of the hand bones (HP:0009699)1.98412499
110Osteolytic defects of the phalanges of the hand (HP:0009771)1.98412499
111Hypoalphalipoproteinemia (HP:0003233)1.98137687
112Short hallux (HP:0010109)1.97620649
113Distal upper limb amyotrophy (HP:0007149)1.97144839
114Upper limb amyotrophy (HP:0009129)1.97144839
115Irregular vertebral endplates (HP:0003301)1.96957183
116Retrobulbar optic neuritis (HP:0100654)1.96234541
117Optic neuritis (HP:0100653)1.96234541
118Abnormality of femoral epiphyses (HP:0006499)1.96161256
119Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.96161256
120Coronal craniosynostosis (HP:0004440)1.94992131
121Hyperparathyroidism (HP:0000843)1.94930099
122Hyperextensible skin (HP:0000974)1.94507049
123Premature skin wrinkling (HP:0100678)1.94201266
124Metaphyseal dysplasia (HP:0100255)1.94157176
125Pulmonary artery stenosis (HP:0004415)1.93313174
126Gowers sign (HP:0003391)1.92538291
127Distal lower limb amyotrophy (HP:0008944)1.92498600
128Type 1 muscle fiber predominance (HP:0003803)1.92469154
129Right ventricular cardiomyopathy (HP:0011663)1.91633852
130Polygenic inheritance (HP:0010982)1.91584757
131Abnormality of the distal phalanges of the toes (HP:0010182)1.90504428
132Bone pain (HP:0002653)1.89184549
133Stridor (HP:0010307)1.89157850
134Abnormal tarsal ossification (HP:0008369)1.88773307
135Thoracolumbar scoliosis (HP:0002944)1.88146665
136Joint stiffness (HP:0001387)1.87700758
137Foot dorsiflexor weakness (HP:0009027)1.87632926
138Intrahepatic cholestasis (HP:0001406)1.86219769
139Diminished motivation (HP:0000745)1.85535843
140Increased serum ferritin (HP:0003281)1.84648210
141Mildly elevated creatine phosphokinase (HP:0008180)1.84458234
142Tetraparesis (HP:0002273)1.84420189
143Prolonged neonatal jaundice (HP:0006579)1.84399060
144Bladder diverticulum (HP:0000015)1.84396664
145Wide anterior fontanel (HP:0000260)1.83664355
146Hypoplasia of the odontoid process (HP:0003311)1.83600070
147Beaking of vertebral bodies (HP:0004568)1.82703146
148Hip contracture (HP:0003273)1.81762050
149Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.81725665
150Bronchomalacia (HP:0002780)1.80882725
151Autoimmune thrombocytopenia (HP:0001973)1.80496525
152Nasal polyposis (HP:0100582)1.80235604
153Difficulty climbing stairs (HP:0003551)1.79523840
154Absent frontal sinuses (HP:0002688)1.79503964
155Protuberant abdomen (HP:0001538)1.78664548
156Cardiovascular calcification (HP:0011915)1.77725507
157Hemorrhage of the eye (HP:0011885)1.77510150
158Peripheral hypomyelination (HP:0007182)1.77371356
159Short nail (HP:0001799)1.77299487
160Disproportionate short-trunk short stature (HP:0003521)1.76974164
161Aneurysm (HP:0002617)1.74155146
162Abnormality of the vasculature of the conjunctiva (HP:0008054)1.72960295
163Progressive neurologic deterioration (HP:0002344)1.71605096
164Eczematoid dermatitis (HP:0000976)1.71061459
165Skin nodule (HP:0200036)1.69333170
166Stroke (HP:0001297)1.68242733
167Metaphyseal irregularity (HP:0003025)1.67819221
168Vascular calcification (HP:0004934)1.66962127
169Ankle contracture (HP:0006466)1.66103027
170Natal tooth (HP:0000695)1.66099588
171Hematochezia (HP:0002573)1.65041893
172Dilatation of the ascending aorta (HP:0005111)1.63180302
173Thoracic kyphosis (HP:0002942)1.62467969

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.82552742
2EPHB14.30505415
3STK393.69744399
4TAOK22.70288877
5ERN12.65010042
6NME22.49196794
7LIMK12.41345925
8DDR22.36366444
9TTN2.33125169
10ICK2.14320756
11WNK42.09284580
12EPHA32.03400015
13TESK12.02265787
14MAPK151.96875022
15GRK71.95519940
16DMPK1.92787713
17PKN11.92636665
18MET1.82305925
19WNK11.70582067
20PRKD31.68163773
21OXSR11.66190935
22SIK11.62963426
23MAP2K31.57068938
24ROCK21.55457629
25PDK21.54609573
26BCR1.53502885
27IRAK11.50499152
28MAP3K111.47997283
29PAK31.46618121
30NTRK11.45616951
31BMX1.43120544
32PAK41.42944172
33TRIB31.42119712
34TAOK11.40185830
35ABL21.38698418
36PHKG21.37634896
37PHKG11.37634896
38TRPM71.35326317
39MAP3K141.34242218
40NEK61.31233405
41PTK2B1.29738422
42TYRO31.27196993
43MST1R1.27102387
44PTK21.26822877
45TYK21.23841127
46PDGFRA1.22387400
47PRPF4B1.21721909
48PIK3CG1.21034112
49MYLK1.14756346
50ROCK11.11121062
51MAP3K11.10111959
52PDGFRB1.08902833
53LMTK21.08654770
54PIM21.04696753
55FGFR21.04225563
56PAK21.02902843
57FGFR41.02714075
58SMG11.02057692
59MATK1.00708094
60MAPKAPK50.98051055
61PRKD10.93734798
62CHUK0.93583577
63ZAP700.93338546
64FER0.91394824
65TESK20.91350975
66IKBKE0.91203614
67TBK10.91094667
68CAMK2D0.91085072
69MUSK0.90297630
70JAK10.88037981
71TGFBR20.83385143
72PIK3CA0.82921785
73BLK0.81333241
74EPHA20.79224831
75PRKCE0.79193329
76NEK90.75172224
77INSR0.74959406
78IRAK40.73692268
79GSK3A0.72847476
80EPHB20.72527968
81PTK60.72034108
82CLK10.69800617
83CSK0.68472749
84JAK30.68023161
85ILK0.67739788
86PRKG20.67676929
87MAP3K60.67546743
88HIPK20.67514798
89STK100.67469230
90NLK0.67222938
91PRKCQ0.67157466
92PAK60.67055916
93LATS20.66143565
94RET0.65723636
95TNIK0.63464028
96FGR0.63084886
97MAPKAPK30.62120418
98MAPK120.61945774
99STK240.61558202
100MARK20.60154920
101MAP3K30.60141779
102CAMK2B0.59293877
103RIPK10.58713336
104IKBKB0.58604390
105PDPK10.57975020
106MAPK70.57503019
107CAMK2G0.57310085
108MTOR0.56278693
109RPS6KA20.55815341
110MOS0.54422700
111BMPR20.54339026
112ERBB40.53991611
113MAP3K50.53375254
114CDK60.53221649
115UHMK10.52672951
116SGK4940.51594045
117SGK2230.51594045
118CDC42BPA0.50881952
119MAPK40.49913889
120MAP2K20.49391555
121PRKCH0.49128299
122CDK90.48448898
123MAP3K20.48169494
124PRKAA20.48168568
125ARAF0.47853870
126MST40.46858025
127INSRR0.46478678
128IRAK20.45572670
129CSNK1A1L0.44488297
130CAMK1G0.43911363
131DAPK30.43643711
132CAMK2A0.43578978
133MAP2K10.43429474
134CDK120.41679237
135PAK10.40957178
136CASK0.40234757
137MAP3K130.39809650
138PKN20.39721731
139MELK0.37564171
140STK380.36983584
141PRKD20.36501917
142MAPKAPK20.34707993
143RPS6KC10.33530011
144RPS6KL10.33530011
145MAP3K80.30495424

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.57607681
2Complement and coagulation cascades_Homo sapiens_hsa046102.04748641
3Dilated cardiomyopathy_Homo sapiens_hsa054141.98934385
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.88902139
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.88669992
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.81433615
7Focal adhesion_Homo sapiens_hsa045101.79745592
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.73323634
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.73147118
10Staphylococcus aureus infection_Homo sapiens_hsa051501.61750196
11Malaria_Homo sapiens_hsa051441.57606169
12Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.57529440
13African trypanosomiasis_Homo sapiens_hsa051431.47932219
14Ether lipid metabolism_Homo sapiens_hsa005651.47616202
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46029510
16Bladder cancer_Homo sapiens_hsa052191.43787544
17Sphingolipid metabolism_Homo sapiens_hsa006001.43404053
18Viral myocarditis_Homo sapiens_hsa054161.42341106
19Axon guidance_Homo sapiens_hsa043601.37844966
20Renal cell carcinoma_Homo sapiens_hsa052111.37050941
21Protein digestion and absorption_Homo sapiens_hsa049741.35054696
22Leishmaniasis_Homo sapiens_hsa051401.27689571
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.27494114
24Ovarian steroidogenesis_Homo sapiens_hsa049131.25478083
25Hepatitis C_Homo sapiens_hsa051601.24455524
26Galactose metabolism_Homo sapiens_hsa000521.21217729
27PPAR signaling pathway_Homo sapiens_hsa033201.18865740
28Influenza A_Homo sapiens_hsa051641.18686601
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.18169958
30Steroid biosynthesis_Homo sapiens_hsa001001.16442217
31Other glycan degradation_Homo sapiens_hsa005111.16322783
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.15322856
33Rheumatoid arthritis_Homo sapiens_hsa053231.15158417
34Proteoglycans in cancer_Homo sapiens_hsa052051.14877602
35Amoebiasis_Homo sapiens_hsa051461.14583528
36Regulation of actin cytoskeleton_Homo sapiens_hsa048101.14212172
37Tuberculosis_Homo sapiens_hsa051521.13403637
38Dorso-ventral axis formation_Homo sapiens_hsa043201.12787875
39Legionellosis_Homo sapiens_hsa051341.12717992
40Fatty acid elongation_Homo sapiens_hsa000621.11709627
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10046150
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.09423492
43Lysosome_Homo sapiens_hsa041421.07980991
44Phenylalanine metabolism_Homo sapiens_hsa003601.05934944
45Prion diseases_Homo sapiens_hsa050201.03534604
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.03079323
47Autoimmune thyroid disease_Homo sapiens_hsa053201.02743681
48Tight junction_Homo sapiens_hsa045301.02307575
49TGF-beta signaling pathway_Homo sapiens_hsa043501.01357703
50Osteoclast differentiation_Homo sapiens_hsa043800.99513290
51Toxoplasmosis_Homo sapiens_hsa051450.99486916
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99448885
53Sulfur metabolism_Homo sapiens_hsa009200.99425212
54PI3K-Akt signaling pathway_Homo sapiens_hsa041510.96134746
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92724756
56Ras signaling pathway_Homo sapiens_hsa040140.92404981
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.91428934
58Endocytosis_Homo sapiens_hsa041440.89781730
59Allograft rejection_Homo sapiens_hsa053300.89590046
60Vibrio cholerae infection_Homo sapiens_hsa051100.89217725
61Adherens junction_Homo sapiens_hsa045200.88729130
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87274721
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.86274606
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.84123932
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.82898572
66Acute myeloid leukemia_Homo sapiens_hsa052210.81996551
67Hippo signaling pathway_Homo sapiens_hsa043900.81767553
68Fructose and mannose metabolism_Homo sapiens_hsa000510.81130294
69TNF signaling pathway_Homo sapiens_hsa046680.80978973
70Cardiac muscle contraction_Homo sapiens_hsa042600.80801641
71MAPK signaling pathway_Homo sapiens_hsa040100.79642346
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78605225
73Shigellosis_Homo sapiens_hsa051310.78555173
74Asthma_Homo sapiens_hsa053100.77731901
75Phagosome_Homo sapiens_hsa041450.76503013
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76133840
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.76037325
78Chronic myeloid leukemia_Homo sapiens_hsa052200.75835474
79Hepatitis B_Homo sapiens_hsa051610.75481846
80Hedgehog signaling pathway_Homo sapiens_hsa043400.75263487
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74725319
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74542879
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73688748
84Notch signaling pathway_Homo sapiens_hsa043300.73586929
85cAMP signaling pathway_Homo sapiens_hsa040240.73569810
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.72893629
87Hematopoietic cell lineage_Homo sapiens_hsa046400.72226594
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70573959
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70435641
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69719588
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.69103463
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69072693
93ErbB signaling pathway_Homo sapiens_hsa040120.68839926
94Rap1 signaling pathway_Homo sapiens_hsa040150.67874311
95Salmonella infection_Homo sapiens_hsa051320.67600265
96Insulin resistance_Homo sapiens_hsa049310.67245047
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67023342
98Prolactin signaling pathway_Homo sapiens_hsa049170.66242599
99Measles_Homo sapiens_hsa051620.64840444
100Chemokine signaling pathway_Homo sapiens_hsa040620.63729265
101Renin secretion_Homo sapiens_hsa049240.63493534
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62787800
103Gastric acid secretion_Homo sapiens_hsa049710.62720533
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62312517
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.61855869
106Graft-versus-host disease_Homo sapiens_hsa053320.61682950
107Chemical carcinogenesis_Homo sapiens_hsa052040.61467268
108Oxytocin signaling pathway_Homo sapiens_hsa049210.61444534
109Cholinergic synapse_Homo sapiens_hsa047250.61102671
110NF-kappa B signaling pathway_Homo sapiens_hsa040640.60344419
111Arachidonic acid metabolism_Homo sapiens_hsa005900.60335060
112Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59523246
113Platelet activation_Homo sapiens_hsa046110.59047157
114Tyrosine metabolism_Homo sapiens_hsa003500.57588895
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57483378
116Estrogen signaling pathway_Homo sapiens_hsa049150.57219153
117Serotonergic synapse_Homo sapiens_hsa047260.56516493
118Type II diabetes mellitus_Homo sapiens_hsa049300.56416259
119Gap junction_Homo sapiens_hsa045400.56363182
120VEGF signaling pathway_Homo sapiens_hsa043700.55756979
121Salivary secretion_Homo sapiens_hsa049700.55184583
122Cocaine addiction_Homo sapiens_hsa050300.54768228
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53920768
124Pertussis_Homo sapiens_hsa051330.53455643
125T cell receptor signaling pathway_Homo sapiens_hsa046600.53385627
126Prostate cancer_Homo sapiens_hsa052150.52714240
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52447567
128Toll-like receptor signaling pathway_Homo sapiens_hsa046200.51402656
129Histidine metabolism_Homo sapiens_hsa003400.51304183
130Pancreatic cancer_Homo sapiens_hsa052120.51243033
131Herpes simplex infection_Homo sapiens_hsa051680.51238321
132Apoptosis_Homo sapiens_hsa042100.50770527
133Glutamatergic synapse_Homo sapiens_hsa047240.50691786
134Long-term depression_Homo sapiens_hsa047300.50446034
135Circadian entrainment_Homo sapiens_hsa047130.49741610
136MicroRNAs in cancer_Homo sapiens_hsa052060.49573915
137Choline metabolism in cancer_Homo sapiens_hsa052310.49495555
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.49346074
139Starch and sucrose metabolism_Homo sapiens_hsa005000.49185517
140Small cell lung cancer_Homo sapiens_hsa052220.48562519
141Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47709094
142Mineral absorption_Homo sapiens_hsa049780.47077438
143Glutathione metabolism_Homo sapiens_hsa004800.42150678
144Drug metabolism - other enzymes_Homo sapiens_hsa009830.42031570
145Steroid hormone biosynthesis_Homo sapiens_hsa001400.41973869
146Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41198251
147Bile secretion_Homo sapiens_hsa049760.40658285
148Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40657729
149Insulin signaling pathway_Homo sapiens_hsa049100.39344221
150Pentose phosphate pathway_Homo sapiens_hsa000300.38472990
151B cell receptor signaling pathway_Homo sapiens_hsa046620.36728282

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