SPSB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal suppressor of cytokine signaling (SOCS) box. This protein plays a role in cell signaling. This gene is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1GDP-mannose metabolic process (GO:0019673)9.15199141
2cellular response to ATP (GO:0071318)7.47726662
3DNA strand renaturation (GO:0000733)7.42926193
4adenosine receptor signaling pathway (GO:0001973)6.97177803
5negative regulation of cell aging (GO:0090344)6.69822687
6G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)6.61101949
7regulation of skeletal muscle contraction (GO:0014819)6.46358536
8meiotic chromosome segregation (GO:0045132)6.38075495
9rRNA methylation (GO:0031167)5.99601020
10purinergic nucleotide receptor signaling pathway (GO:0035590)5.71321963
11rRNA modification (GO:0000154)5.58743921
12lens fiber cell differentiation (GO:0070306)5.29764562
13UV protection (GO:0009650)5.14108098
14negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.13665905
15purine ribonucleotide transport (GO:0015868)4.96611191
16adenine nucleotide transport (GO:0051503)4.69919954
17sulfur amino acid catabolic process (GO:0000098)4.63371947
18mitotic cell cycle arrest (GO:0071850)4.60961259
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.59186081
20L-phenylalanine metabolic process (GO:0006558)4.59186081
21mannose metabolic process (GO:0006013)4.52010471
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.49425840
23L-phenylalanine catabolic process (GO:0006559)4.49425840
24purinergic receptor signaling pathway (GO:0035587)4.44667985
25positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.43198776
26positive regulation of protein kinase C signaling (GO:0090037)4.41293008
27G-protein coupled purinergic receptor signaling pathway (GO:0035588)4.37453487
28regulation of cytokine production involved in inflammatory response (GO:1900015)4.35517568
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.35217175
30nucleoside transmembrane transport (GO:1901642)4.27943910
31nucleotide-sugar biosynthetic process (GO:0009226)4.25743453
32response to ATP (GO:0033198)4.19001520
33regulation of synapse structural plasticity (GO:0051823)4.09227796
34cysteine metabolic process (GO:0006534)4.03884463
35nucleotide transmembrane transport (GO:1901679)4.03833367
36glyoxylate metabolic process (GO:0046487)3.90074727
37sensory perception of taste (GO:0050909)3.89058624
38alpha-linolenic acid metabolic process (GO:0036109)3.86955814
39folic acid metabolic process (GO:0046655)3.85101972
40aromatic amino acid family catabolic process (GO:0009074)3.84916806
41sphingomyelin metabolic process (GO:0006684)3.84501094
42tRNA modification (GO:0006400)3.83054078
43peptidyl-glutamic acid carboxylation (GO:0017187)3.76595353
44protein carboxylation (GO:0018214)3.76595353
45positive regulation of heat generation (GO:0031652)3.76063567
46sphingosine metabolic process (GO:0006670)3.74890238
47DNA replication checkpoint (GO:0000076)3.70902668
48transepithelial transport (GO:0070633)3.70359216
49purine nucleotide transport (GO:0015865)3.63136899
50pseudouridine synthesis (GO:0001522)3.60025056
51aldehyde catabolic process (GO:0046185)3.57174363
52negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.57015740
53regulation of cell aging (GO:0090342)3.53130942
54drug transmembrane transport (GO:0006855)3.48567802
55drug transport (GO:0015893)3.45373086
56protein insertion into membrane (GO:0051205)3.45098588
57iron-sulfur cluster assembly (GO:0016226)3.44853923
58metallo-sulfur cluster assembly (GO:0031163)3.44853923
59triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.42363839
60ribosomal small subunit biogenesis (GO:0042274)3.40772969
61cellular glucuronidation (GO:0052695)3.40559268
62tryptophan catabolic process (GO:0006569)3.39671698
63indole-containing compound catabolic process (GO:0042436)3.39671698
64indolalkylamine catabolic process (GO:0046218)3.39671698
65bile acid biosynthetic process (GO:0006699)3.39470853
66negative regulation of interleukin-8 production (GO:0032717)3.37890880
67diol metabolic process (GO:0034311)3.36623437
68primary alcohol catabolic process (GO:0034310)3.35517624
69amino-acid betaine metabolic process (GO:0006577)3.34928701
70regulation of cholesterol homeostasis (GO:2000188)3.34427656
71lysine metabolic process (GO:0006553)3.33206526
72lysine catabolic process (GO:0006554)3.33206526
73tryptophan metabolic process (GO:0006568)3.30301357
74urate metabolic process (GO:0046415)3.28908382
75nucleoside transport (GO:0015858)3.28229602
76uronic acid metabolic process (GO:0006063)3.27955818
77glucuronate metabolic process (GO:0019585)3.27955818
78base-excision repair, AP site formation (GO:0006285)3.24693831
79phosphatidylglycerol biosynthetic process (GO:0006655)3.24591325
80kynurenine metabolic process (GO:0070189)3.24286478
81COPI coating of Golgi vesicle (GO:0048205)3.20992505
82Golgi transport vesicle coating (GO:0048200)3.20992505
83regulation of nuclear cell cycle DNA replication (GO:0033262)3.20704991
84melanin biosynthetic process (GO:0042438)3.20620997
85peptidyl-histidine modification (GO:0018202)3.19398026
86histone phosphorylation (GO:0016572)3.18253737
87negative regulation of tumor necrosis factor production (GO:0032720)3.18078003
88plasma lipoprotein particle clearance (GO:0034381)3.18070805
89serine family amino acid catabolic process (GO:0009071)3.17643532
90complement activation, alternative pathway (GO:0006957)3.17506553
91granulocyte differentiation (GO:0030851)3.16668143
92proline biosynthetic process (GO:0006561)3.15959569
93folic acid transport (GO:0015884)3.14335386
94pyrimidine nucleoside salvage (GO:0043097)3.14093072
95pyrimidine-containing compound salvage (GO:0008655)3.14093072
96regulation of interferon-beta biosynthetic process (GO:0045357)3.13725542
97drug catabolic process (GO:0042737)3.13216162
98nucleotide salvage (GO:0043173)3.12906520
99ethanol metabolic process (GO:0006067)3.08286379
100negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)3.07843015
101antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.05180920
102antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.05180920
103valine metabolic process (GO:0006573)3.04889166
104cellular ketone body metabolic process (GO:0046950)3.04839739
105cellular modified amino acid catabolic process (GO:0042219)3.04055885
106iron coordination entity transport (GO:1901678)3.03452222
107ethanol oxidation (GO:0006069)3.02538125
108modulation by virus of host process (GO:0019054)3.01050351
109dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.00855092
110interferon-gamma production (GO:0032609)2.98488077
111carnitine metabolic process (GO:0009437)2.96497333
112urea metabolic process (GO:0019627)2.94979525
113urea cycle (GO:0000050)2.94979525
114homocysteine metabolic process (GO:0050667)2.94978728
115low-density lipoprotein particle clearance (GO:0034383)2.94749949
116detection of light stimulus involved in visual perception (GO:0050908)2.93516534
117detection of light stimulus involved in sensory perception (GO:0050962)2.93516534
118regulation of protein activation cascade (GO:2000257)2.93364767
119fatty acid beta-oxidation (GO:0006635)2.92784332
120high-density lipoprotein particle remodeling (GO:0034375)2.92608489
121nucleoside salvage (GO:0043174)2.92438289
122cellular response to virus (GO:0098586)2.90733261
123melanin metabolic process (GO:0006582)2.89031432
124purine deoxyribonucleotide catabolic process (GO:0009155)2.89012012
125fatty acid oxidation (GO:0019395)2.88821913
126aromatic amino acid family metabolic process (GO:0009072)2.87376587
127phosphatidylethanolamine biosynthetic process (GO:0006646)2.86800819
128serine family amino acid metabolic process (GO:0009069)2.86496371
129lipid oxidation (GO:0034440)2.86211428
130purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.86163454
131ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.86163454
132nucleoside bisphosphate biosynthetic process (GO:0033866)2.86163454
133tricarboxylic acid metabolic process (GO:0072350)2.83687789
134regulation of complement activation (GO:0030449)2.83575754
135bile acid metabolic process (GO:0008206)2.81825026
136RNA modification (GO:0009451)2.81144543
137regulation of triglyceride catabolic process (GO:0010896)2.80370067
138positive regulation of triglyceride lipase activity (GO:0061365)2.80135950
139positive regulation of lipoprotein lipase activity (GO:0051006)2.80135950
140exogenous drug catabolic process (GO:0042738)2.79604826
141nitrogen cycle metabolic process (GO:0071941)2.78933430
142flavonoid metabolic process (GO:0009812)2.77736076
143regulation of protein kinase A signaling (GO:0010738)2.77400865
144cofactor catabolic process (GO:0051187)2.77286305
145estrogen biosynthetic process (GO:0006703)2.76730748
146lipoprotein metabolic process (GO:0042157)2.76542248
147regulation of cholesterol metabolic process (GO:0090181)2.76513795
148RNA methylation (GO:0001510)2.76214772
1494-hydroxyproline metabolic process (GO:0019471)2.75699796
150grooming behavior (GO:0007625)2.75136487
151phosphate ion homeostasis (GO:0055062)2.74198407
152trivalent inorganic anion homeostasis (GO:0072506)2.74198407
153antigen processing and presentation of endogenous antigen (GO:0019883)2.74020374
154pentose-phosphate shunt (GO:0006098)2.73911463
155regulation of cholesterol esterification (GO:0010872)2.73180540
156misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.72688049
157NADP metabolic process (GO:0006739)2.71416557
158organic cation transport (GO:0015695)2.70530378
159negative regulation of fibrinolysis (GO:0051918)2.70457998
160positive regulation of triglyceride metabolic process (GO:0090208)2.70403907
161fatty acid catabolic process (GO:0009062)2.69848311
162cardiolipin metabolic process (GO:0032048)2.69187872
163regulation of cholesterol storage (GO:0010885)2.69109180
164phospholipid efflux (GO:0033700)2.67650601
165ketone body metabolic process (GO:1902224)2.67439139
166sex determination (GO:0007530)2.67421728
167positive regulation of protein homooligomerization (GO:0032464)2.66458320
168cellular anion homeostasis (GO:0030002)2.66056845
169regulation of type I interferon-mediated signaling pathway (GO:0060338)2.65000988
170renal absorption (GO:0070293)2.64898259
171alpha-amino acid catabolic process (GO:1901606)2.64826701
172cellular amino acid catabolic process (GO:0009063)2.64093383
173type B pancreatic cell proliferation (GO:0044342)2.63833198
174NADPH regeneration (GO:0006740)2.61986548
175tyrosine metabolic process (GO:0006570)2.61606090
176serine family amino acid biosynthetic process (GO:0009070)2.61571149
177killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.60485362
178disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.60485362
179monocarboxylic acid catabolic process (GO:0072329)2.60044631
180response to peptidoglycan (GO:0032494)2.59707391
181fructose metabolic process (GO:0006000)2.59289102
182reverse cholesterol transport (GO:0043691)2.58990591
183bile acid and bile salt transport (GO:0015721)2.58350951
184positive regulation of fatty acid biosynthetic process (GO:0045723)2.57928377
185positive regulation of triglyceride biosynthetic process (GO:0010867)2.57910733
186peptide catabolic process (GO:0043171)2.57798225
187carboxylic acid catabolic process (GO:0046395)2.56216034
188organic acid catabolic process (GO:0016054)2.56216034
189coenzyme catabolic process (GO:0009109)2.55617594
190regulated secretory pathway (GO:0045055)2.55442813
191negative regulation of cholesterol transport (GO:0032375)2.55279114
192negative regulation of sterol transport (GO:0032372)2.55279114
193sphingoid metabolic process (GO:0046519)2.55015505
194gonadal mesoderm development (GO:0007506)2.54649399
195keratan sulfate metabolic process (GO:0042339)2.54527455
196plasma lipoprotein particle assembly (GO:0034377)2.54337681
197cornea development in camera-type eye (GO:0061303)2.53558097

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.84217870
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.20930219
3PPARA_22158963_ChIP-Seq_LIVER_Mouse3.96560116
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.33832209
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.18245400
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.06890826
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.96668947
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.87266515
9P68_20966046_ChIP-Seq_HELA_Human2.51307329
10XRN2_22483619_ChIP-Seq_HELA_Human2.46836942
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.38271156
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.36858217
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.32542784
14DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.25111453
15* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.21139148
16MAF_26560356_Chip-Seq_TH2_Human2.17567950
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16768032
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.14432531
19CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.14309588
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.99024497
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.94488288
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89047400
23E2F1_20622854_ChIP-Seq_HELA_Human1.85496665
24CTCF_27219007_Chip-Seq_ERYTHROID_Human1.81212112
25PHF8_20622854_ChIP-Seq_HELA_Human1.77404193
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.72682938
27KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.72391175
28* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71429933
29RARB_24833708_ChIP-Seq_LIVER_Mouse1.69917862
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68321537
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.64328929
32MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.63943218
33MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.62166826
34SMC4_20622854_ChIP-Seq_HELA_Human1.61992565
35SA1_27219007_Chip-Seq_ERYTHROID_Human1.61351371
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.59654418
37* FOXP1_21924763_ChIP-Seq_HESCs_Human1.57337843
38SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.56622698
39* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.56445191
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56079629
41SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55593662
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54844031
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.54208145
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53489827
45* CTCF_21964334_Chip-Seq_Bcells_Human1.52795532
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52077880
47IRF8_27001747_Chip-Seq_BMDM_Mouse1.52073696
48* CTCF_27219007_Chip-Seq_Bcells_Human1.51491840
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.50510828
50* RARA_24833708_ChIP-Seq_LIVER_Mouse1.50343757
51* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.49744063
52KDM2B_26808549_Chip-Seq_DND41_Human1.49293168
53STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.46936102
54CLOCK_20551151_ChIP-Seq_293T_Human1.46284448
55Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.46256725
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45909588
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.44540301
58VDR_21846776_ChIP-Seq_THP-1_Human1.43916233
59YY1_22570637_ChIP-Seq_MALME-3M_Human1.43508525
60DCP1A_22483619_ChIP-Seq_HELA_Human1.42626096
61SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42060019
62EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41452866
63GABP_19822575_ChIP-Seq_HepG2_Human1.40085696
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39255284
65* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.38854408
66MYC_18358816_ChIP-ChIP_MESCs_Mouse1.38716164
67* LXR_22292898_ChIP-Seq_THP-1_Human1.38234621
68CTCF_20526341_ChIP-Seq_ESCs_Human1.37740780
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36455797
70* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35299715
71FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.33512459
72STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32496010
73SA1_27219007_Chip-Seq_Bcells_Human1.31431071
74DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.31355794
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.31012333
76CTCF_21964334_ChIP-Seq_BJAB-B_Human1.30599377
77SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30481286
78SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30390431
79TP53_22127205_ChIP-Seq_IMR90_Human1.29802169
80GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29507409
81ETS1_20019798_ChIP-Seq_JURKAT_Human1.28907329
82* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.28808692
83PU.1_20513432_ChIP-Seq_Bcells_Mouse1.27641720
84* TCF7_22412390_ChIP-Seq_EML_Mouse1.27574313
85* CREB1_26743006_Chip-Seq_LNCaP_Human1.26957353
86ELK3_25401928_ChIP-Seq_HUVEC_Human1.26852545
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25660566
88TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.25205121
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25051405
90RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.23912637
91FOXM1_23109430_ChIP-Seq_U2OS_Human1.22852588
92LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22322341
93EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.21492626
94TP63_17297297_ChIP-ChIP_HaCaT_Human1.21015250
95* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20829294
96NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.20708604
97ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.20116113
98GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19642981
99THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17421981
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17172576
101* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16940424
102VDR_24763502_ChIP-Seq_THP-1_Human1.16870824
103E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16863375
104NCOR1_26117541_ChIP-Seq_K562_Human1.16446291
105CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16266942
106SPI1_23547873_ChIP-Seq_NB4_Human1.16262130
107CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16225497
108* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.15484059
109RUNX1_22412390_ChIP-Seq_EML_Mouse1.14841869
110ERA_21632823_ChIP-Seq_H3396_Human1.13538974
111TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.13440221
112PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12850621
113CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12477194
114E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11078853
115SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10706280
116ETS1_21867929_ChIP-Seq_TH2_Mouse1.10618250
117BCL6_27268052_Chip-Seq_Bcells_Human1.08988255
118CIITA_25753668_ChIP-Seq_RAJI_Human1.08531209
119KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08194761
120SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08169020
121* RACK7_27058665_Chip-Seq_MCF-7_Human1.07734440
122EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06999921
123PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06873233
124ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06859609
125LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06761994
126MAF_26560356_Chip-Seq_TH1_Human1.06641094
127CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06505951
128TET1_21451524_ChIP-Seq_MESCs_Mouse1.05878200
129TFEB_21752829_ChIP-Seq_HELA_Human1.05772609
130CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04702534
131* ATF3_27146783_Chip-Seq_COLON_Human1.04606272
132IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04002949
133SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02765313
134TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02118867
135P300_27268052_Chip-Seq_Bcells_Human1.01705707
136NOTCH1_21737748_ChIP-Seq_TLL_Human1.01327224
137PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99311538
138BCOR_27268052_Chip-Seq_Bcells_Human0.98748107
139ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.98012039
140MYC_22102868_ChIP-Seq_BL_Human0.97914896
141TRIM28_21343339_ChIP-Seq_HEK293_Human0.96773352
142PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96613489
143GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96483497
144SRF_21415370_ChIP-Seq_HL-1_Mouse0.95332777
145ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94908601
146SCL_19346495_ChIP-Seq_HPC-7_Human0.94276208
147ELF1_20517297_ChIP-Seq_JURKAT_Human0.94071702
148SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93843451
149* UTX_26944678_Chip-Seq_JUKART_Human0.92742604
150* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.91869409
151RXRA_24833708_ChIP-Seq_LIVER_Mouse0.91741989
152CTCF_26484167_Chip-Seq_Bcells_Mouse0.91075791
153JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.88795474
154* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88481608
155TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88251190
156CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87509535
157P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87429831
158SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87123487
159NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.86868098
160STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.85976182
161EGR1_19374776_ChIP-ChIP_THP-1_Human0.85647075

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity5.81305491
2MP0005171_absent_coat_pigmentation5.72733314
3MP0005174_abnormal_tail_pigmentation4.88637769
4MP0002139_abnormal_hepatobiliary_system4.69146690
5MP0003136_yellow_coat_color4.68179695
6MP0005360_urolithiasis4.45894951
7MP0005423_abnormal_somatic_nervous4.35236293
8MP0005365_abnormal_bile_salt3.35687311
9MP0009840_abnormal_foam_cell3.16121621
10MP0008875_abnormal_xenobiotic_pharmacok3.07761457
11MP0005085_abnormal_gallbladder_physiolo3.01650172
12MP0003806_abnormal_nucleotide_metabolis2.91329589
13MP0005058_abnormal_lysosome_morphology2.75163548
14MP0003191_abnormal_cellular_cholesterol2.57619157
15MP0001188_hyperpigmentation2.46077062
16MP0005083_abnormal_biliary_tract2.40296894
17MP0003252_abnormal_bile_duct2.39136976
18MP0001661_extended_life_span2.31168353
19MP0005409_darkened_coat_color2.28960456
20MP0005332_abnormal_amino_acid2.21369559
21MP0003436_decreased_susceptibility_to2.18271349
22MP0003453_abnormal_keratinocyte_physiol2.15032489
23MP0002138_abnormal_hepatobiliary_system2.13876895
24MP0000750_abnormal_muscle_regeneration2.09294922
25MP0010329_abnormal_lipoprotein_level2.07310885
26MP0003195_calcinosis2.06818107
27MP0000015_abnormal_ear_pigmentation2.06091342
28MP0003111_abnormal_nucleus_morphology1.92478222
29MP0003693_abnormal_embryo_hatching1.88241652
30MP0009643_abnormal_urine_homeostasis1.88087706
31MP0004381_abnormal_hair_follicle1.86374844
32MP0003172_abnormal_lysosome_physiology1.78980209
33MP0004019_abnormal_vitamin_homeostasis1.77756217
34MP0000685_abnormal_immune_system1.76498764
35MP0003186_abnormal_redox_activity1.75233443
36MP0009785_altered_susceptibility_to1.69633806
37MP0001666_abnormal_nutrient_absorption1.68582367
38MP0000609_abnormal_liver_physiology1.65910868
39MP0006082_CNS_inflammation1.65094992
40MP0005319_abnormal_enzyme/_coenzyme1.64812861
41MP0003183_abnormal_peptide_metabolism1.64677393
42MP0000751_myopathy1.60908463
43MP0001835_abnormal_antigen_presentation1.60821917
44MP0003724_increased_susceptibility_to1.60436039
45MP0005076_abnormal_cell_differentiation1.56841583
46MP0005330_cardiomyopathy1.54373146
47MP0001502_abnormal_circadian_rhythm1.53435056
48MP0005464_abnormal_platelet_physiology1.49556825
49MP0003705_abnormal_hypodermis_morpholog1.48440550
50MP0010234_abnormal_vibrissa_follicle1.47240243
51MP0003303_peritoneal_inflammation1.46366239
52MP0005501_abnormal_skin_physiology1.44449841
53MP0001968_abnormal_touch/_nociception1.43610648
54MP0008469_abnormal_protein_level1.43467804
55MP0002118_abnormal_lipid_homeostasis1.40349649
56MP0002419_abnormal_innate_immunity1.39946284
57MP0000013_abnormal_adipose_tissue1.39907570
58MP0002160_abnormal_reproductive_system1.38853377
59MP0000538_abnormal_urinary_bladder1.37341327
60MP0003300_gastrointestinal_ulcer1.36250940
61MP0005636_abnormal_mineral_homeostasis1.35640877
62MP0001533_abnormal_skeleton_physiology1.35527607
63MP0000003_abnormal_adipose_tissue1.35006897
64MP0003656_abnormal_erythrocyte_physiolo1.31536592
65MP0005584_abnormal_enzyme/coenzyme_acti1.30404707
66MP0004957_abnormal_blastocyst_morpholog1.26797895
67MP0005025_abnormal_response_to1.26131116
68MP0002638_abnormal_pupillary_reflex1.25659002
69MP0004130_abnormal_muscle_cell1.24704157
70MP0009278_abnormal_bone_marrow1.22239169
71MP0005220_abnormal_exocrine_pancreas1.22151905
72MP0001756_abnormal_urination1.21514691
73MP0004947_skin_inflammation1.16948248
74MP0002136_abnormal_kidney_physiology1.14639637
75MP0002933_joint_inflammation1.13524736
76MP0000604_amyloidosis1.12318356
77MP0001845_abnormal_inflammatory_respons1.11333763
78MP0001764_abnormal_homeostasis1.10668004
79MP0004782_abnormal_surfactant_physiolog1.09243109
80MP0003077_abnormal_cell_cycle1.08109043
81MP0005257_abnormal_intraocular_pressure1.07867841
82MP0000598_abnormal_liver_morphology1.06702759
83MP0002877_abnormal_melanocyte_morpholog1.05880301
84MP0008438_abnormal_cutaneous_collagen1.05859659
85MP0005000_abnormal_immune_tolerance1.05202267
86MP0000858_altered_metastatic_potential1.04250787
87MP0001790_abnormal_immune_system1.03489052
88MP0005387_immune_system_phenotype1.03489052
89MP0003448_altered_tumor_morphology1.02778523
90MP0009764_decreased_sensitivity_to1.02465349
91MP0005670_abnormal_white_adipose1.02345427
92MP0001873_stomach_inflammation1.01394120
93MP0005084_abnormal_gallbladder_morpholo1.00066518
94MP0003868_abnormal_feces_composition0.97757723
95MP0002452_abnormal_antigen_presenting0.96360096
96MP0002019_abnormal_tumor_incidence0.92700188
97MP0003878_abnormal_ear_physiology0.92567360
98MP0005377_hearing/vestibular/ear_phenot0.92567360
99MP0001765_abnormal_ion_homeostasis0.92558740
100MP0004043_abnormal_pH_regulation0.91814893
101MP0005451_abnormal_body_composition0.91456060
102MP0010155_abnormal_intestine_physiology0.91440797
103MP0002148_abnormal_hypersensitivity_rea0.91262605
104MP0001800_abnormal_humoral_immune0.91222075
105MP0004185_abnormal_adipocyte_glucose0.90543879
106MP0005023_abnormal_wound_healing0.90469079
107MP0003075_altered_response_to0.90095723
108MP0002736_abnormal_nociception_after0.89809464
109MP0009763_increased_sensitivity_to0.89535534
110MP0009931_abnormal_skin_appearance0.89095258
111MP0003011_delayed_dark_adaptation0.88916551
112MP0002254_reproductive_system_inflammat0.88503777
113MP0002723_abnormal_immune_serum0.88413283
114MP0000470_abnormal_stomach_morphology0.88224439
115* MP0009642_abnormal_blood_homeostasis0.87903846
116MP0006054_spinal_hemorrhage0.86785528
117MP0001919_abnormal_reproductive_system0.84764235
118MP0002277_abnormal_respiratory_mucosa0.81578385
119MP0003566_abnormal_cell_adhesion0.80164890
120MP0002132_abnormal_respiratory_system0.79776644
121MP0000747_muscle_weakness0.79621038
122MP0003279_aneurysm0.79372916
123MP0005166_decreased_susceptibility_to0.77149699
124MP0002405_respiratory_system_inflammati0.76646340
125MP0009333_abnormal_splenocyte_physiolog0.76178283
126MP0005671_abnormal_response_to0.75111415
127MP0000343_altered_response_to0.74759029
128MP0001819_abnormal_immune_cell0.74678334
129MP0001853_heart_inflammation0.74356202
130MP0001545_abnormal_hematopoietic_system0.74256051
131MP0005397_hematopoietic_system_phenotyp0.74256051
132MP0002420_abnormal_adaptive_immunity0.73876554
133MP0000367_abnormal_coat/_hair0.72626094
134MP0002928_abnormal_bile_duct0.71667696
135MP0004264_abnormal_extraembryonic_tissu0.70563319
136MP0002078_abnormal_glucose_homeostasis0.70535251
137MP0005410_abnormal_fertilization0.68997588
138MP0000358_abnormal_cell_content/0.68996218
139MP0005375_adipose_tissue_phenotype0.68838493
140MP0001664_abnormal_digestion0.68363916
141MP0002135_abnormal_kidney_morphology0.68203979
142MP0008260_abnormal_autophagy0.68179271
143MP0001663_abnormal_digestive_system0.66958812
144MP0000689_abnormal_spleen_morphology0.66383272
145MP0001542_abnormal_bone_strength0.65678747
146MP0010386_abnormal_urinary_bladder0.65344399
147MP0005389_reproductive_system_phenotype0.63358612
148* MP0002429_abnormal_blood_cell0.62180055
149MP0000678_abnormal_parathyroid_gland0.59656645
150MP0008874_decreased_physiological_sensi0.58712315
151MP0010094_abnormal_chromosome_stability0.58011922
152MP0000313_abnormal_cell_death0.56602560
153MP0010771_integument_phenotype0.55939281
154MP0001191_abnormal_skin_condition0.55183884
155MP0006036_abnormal_mitochondrial_physio0.55087046
156MP0001958_emphysema0.53500952
157MP0001905_abnormal_dopamine_level0.53446808
158MP0000716_abnormal_immune_system0.53069468
159MP0002735_abnormal_chemical_nociception0.52838996
160MP0006035_abnormal_mitochondrial_morpho0.51500659
161MP0002075_abnormal_coat/hair_pigmentati0.51442652

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)6.29307159
2Rib fusion (HP:0000902)5.52623005
3Poikiloderma (HP:0001029)5.38159723
4Rectovaginal fistula (HP:0000143)5.04256863
5Rectal fistula (HP:0100590)5.04256863
6Vaginal fistula (HP:0004320)5.00931984
7Intestinal fistula (HP:0100819)4.76870619
8Abnormality of aromatic amino acid family metabolism (HP:0004338)4.63962317
9Attenuation of retinal blood vessels (HP:0007843)4.55047057
10Dyschromatopsia (HP:0007641)4.54606119
11Ulnar bowing (HP:0003031)4.52262556
12Thin bony cortex (HP:0002753)4.36866919
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.03177178
14Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.00923764
15Annular pancreas (HP:0001734)3.96508374
16Xanthomatosis (HP:0000991)3.90768078
17Facial diplegia (HP:0001349)3.83723937
18Turricephaly (HP:0000262)3.80722524
19Akinesia (HP:0002304)3.72549255
20Hemorrhage of the eye (HP:0011885)3.69645430
21Popliteal pterygium (HP:0009756)3.68615903
22Squamous cell carcinoma (HP:0002860)3.63473922
23Aplasia of the musculature (HP:0100854)3.58981780
24Vacuolated lymphocytes (HP:0001922)3.56997176
25Mesangial abnormality (HP:0001966)3.55504109
26Facial hemangioma (HP:0000329)3.50570429
27Dysostosis multiplex (HP:0000943)3.48481111
28Intrahepatic cholestasis (HP:0001406)3.48436881
29Abnormality of monocarboxylic acid metabolism (HP:0010996)3.46921019
30Mucopolysacchariduria (HP:0008155)3.42362241
31Urinary glycosaminoglycan excretion (HP:0003541)3.42362241
32Congenital stationary night blindness (HP:0007642)3.40024588
33Delayed epiphyseal ossification (HP:0002663)3.36219035
34Recurrent gram-negative bacterial infections (HP:0005420)3.34486652
35Systemic lupus erythematosus (HP:0002725)3.33360953
36Flat acetabular roof (HP:0003180)3.26650722
37Deep venous thrombosis (HP:0002625)3.24590971
38Generalized aminoaciduria (HP:0002909)3.22881575
39Hypoglycemic coma (HP:0001325)3.21618578
40Coronal craniosynostosis (HP:0004440)3.21078707
41Abnormality of glutamine family amino acid metabolism (HP:0010902)3.18970347
42Renal Fanconi syndrome (HP:0001994)3.12913381
43Abnormality of polysaccharide metabolism (HP:0011012)3.11921951
44Abnormality of glycosaminoglycan metabolism (HP:0004371)3.11921951
45Abnormality of mucopolysaccharide metabolism (HP:0011020)3.11921951
46Abnormal albumin level (HP:0012116)3.09352257
47Hypoalbuminemia (HP:0003073)3.09352257
48Anteriorly placed anus (HP:0001545)3.06427991
49Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.03595440
50Eczematoid dermatitis (HP:0000976)3.01300107
51Abnormality of the costochondral junction (HP:0000919)2.98688608
52Fetal akinesia sequence (HP:0001989)2.98325994
53Protuberant abdomen (HP:0001538)2.94920506
54Bony spicule pigmentary retinopathy (HP:0007737)2.94302679
55Abnormality of fatty-acid metabolism (HP:0004359)2.90467548
56Patellar aplasia (HP:0006443)2.90434928
57Hyperlipoproteinemia (HP:0010980)2.90428800
58Complement deficiency (HP:0004431)2.88593142
59Joint stiffness (HP:0001387)2.84561597
60Abnormal tarsal ossification (HP:0008369)2.82383703
61Short chin (HP:0000331)2.78505250
62Increased cerebral lipofuscin (HP:0011813)2.75778062
63Hypobetalipoproteinemia (HP:0003563)2.73846619
64Increased hepatocellular lipid droplets (HP:0006565)2.73657453
65Amniotic constriction ring (HP:0009775)2.73131615
66Abnormality of placental membranes (HP:0011409)2.73131615
67Decreased electroretinogram (ERG) amplitude (HP:0000654)2.72790059
68Aplasia/Hypoplasia of the patella (HP:0006498)2.72508592
69Beaking of vertebral bodies (HP:0004568)2.71831038
70Absent thumb (HP:0009777)2.70689230
71Ketosis (HP:0001946)2.69558559
72Abnormality of complement system (HP:0005339)2.69484541
73Male infertility (HP:0003251)2.69412553
74Joint hemorrhage (HP:0005261)2.66385400
75Prolonged partial thromboplastin time (HP:0003645)2.65742862
76Lipid accumulation in hepatocytes (HP:0006561)2.65595002
77Premature graying of hair (HP:0002216)2.65004562
78Polydipsia (HP:0001959)2.63971177
79Abnormal drinking behavior (HP:0030082)2.63971177
80Axonal loss (HP:0003447)2.62469542
81Abnormality of the common coagulation pathway (HP:0010990)2.61227253
82Abnormality of the intrinsic pathway (HP:0010989)2.61172278
83Recurrent bacterial skin infections (HP:0005406)2.60514835
84Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.60444023
85Bowing of the arm (HP:0006488)2.59859123
86Bowed forearm bones (HP:0003956)2.59859123
87Recurrent abscess formation (HP:0002722)2.58650272
88Increased intramyocellular lipid droplets (HP:0012240)2.57187227
89Myocardial infarction (HP:0001658)2.56420202
90Abnormality of purine metabolism (HP:0004352)2.56042622
91Hypophosphatemic rickets (HP:0004912)2.55934433
92Hyperammonemia (HP:0001987)2.55187751
93Increased neuronal autofluorescent lipopigment (HP:0002074)2.51284369
94Choroideremia (HP:0001139)2.50690973
95Abnormality of macrophages (HP:0004311)2.49587104
96Increased muscle lipid content (HP:0009058)2.49567407
97Chorioretinal atrophy (HP:0000533)2.49278219
98Abnormality of glycosphingolipid metabolism (HP:0004343)2.48565002
99Abnormality of glycolipid metabolism (HP:0010969)2.48565002
100Abnormality of liposaccharide metabolism (HP:0010968)2.48565002
101Decreased central vision (HP:0007663)2.48261257
102Gout (HP:0001997)2.44222527
103Abnormality of sulfur amino acid metabolism (HP:0004339)2.44119463
104Atrioventricular block (HP:0001678)2.41700321
105Late onset (HP:0003584)2.41694558
106Abnormality of dicarboxylic acid metabolism (HP:0010995)2.40614370
107Dicarboxylic aciduria (HP:0003215)2.40614370
108Abdominal distention (HP:0003270)2.39150330
109Vertebral compression fractures (HP:0002953)2.35743515
110Glomerulonephritis (HP:0000099)2.35635040
111Myopathic facies (HP:0002058)2.33829771
112Hypolipoproteinemia (HP:0010981)2.33000004
113Ketoacidosis (HP:0001993)2.32871535
114Enlarged epiphyses (HP:0010580)2.32026464
115Abnormality of nucleobase metabolism (HP:0010932)2.29049520
116Choanal stenosis (HP:0000452)2.28781293
117Widely patent fontanelles and sutures (HP:0004492)2.28067656
118Abnormality of proline metabolism (HP:0010907)2.27970009
119Hydroxyprolinuria (HP:0003080)2.27970009
120Hyperbilirubinemia (HP:0002904)2.27047690
121Reduced antithrombin III activity (HP:0001976)2.26979267
122Hypoalphalipoproteinemia (HP:0003233)2.26030692
123Flat occiput (HP:0005469)2.22761538
124Basal cell carcinoma (HP:0002671)2.22430372
125Malnutrition (HP:0004395)2.21332471
126Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.19573226
127Abnormal enzyme/coenzyme activity (HP:0012379)2.17068729
128Hypoglycemic seizures (HP:0002173)2.16599474
129Sensorimotor neuropathy (HP:0007141)2.15147862
130Abnormal trabecular bone morphology (HP:0100671)2.14997135
131Cheilitis (HP:0100825)2.14886469
132Zonular cataract (HP:0010920)2.14821734
133Pathologic fracture (HP:0002756)2.13672015
134Aplasia/Hypoplasia involving the musculature (HP:0001460)2.13340554
135Capillary hemangiomas (HP:0005306)2.12657944
136Respiratory difficulties (HP:0002880)2.10616237
137Hyperglycinuria (HP:0003108)2.09768202
138Neonatal onset (HP:0003623)2.07646525
139Abnormality of alkaline phosphatase activity (HP:0004379)2.06775391
140Fat malabsorption (HP:0002630)2.06106941
141Abnormal foot bone ossification (HP:0010675)2.06103861
142Abnormal epiphyseal ossification (HP:0010656)2.05947391
143Thoracic kyphosis (HP:0002942)2.04708761
144Abnormality of aspartate family amino acid metabolism (HP:0010899)2.04697743
145Nasal polyposis (HP:0100582)2.03589650
146Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.02343073
147Birth length less than 3rd percentile (HP:0003561)2.01781543
148Hypercholesterolemia (HP:0003124)2.01709287
149Proximal tubulopathy (HP:0000114)2.01643946
150Elevated alkaline phosphatase (HP:0003155)2.01355095
151Petechiae (HP:0000967)1.99788129
152Nausea (HP:0002018)1.97176194
153Abnormality of the nasal mucosa (HP:0000433)1.95276898
154Cervical subluxation (HP:0003308)1.94569301
155Cupped ribs (HP:0000887)1.94488574
156Breast hypoplasia (HP:0003187)1.93865634
157Loss of speech (HP:0002371)1.93626236
158Tetraparesis (HP:0002273)1.93361320
159Ovoid vertebral bodies (HP:0003300)1.92451426
160Irritability (HP:0000737)1.92421182
161Exertional dyspnea (HP:0002875)1.91483939
162Symptomatic seizures (HP:0011145)1.91179061
163Abnormal platelet function (HP:0011869)1.91119118
164Impaired platelet aggregation (HP:0003540)1.91119118
165Opisthotonus (HP:0002179)1.90993246
166Mitral stenosis (HP:0001718)1.90491511
167Diminished movement (HP:0002374)1.90190469
168Gingival bleeding (HP:0000225)1.89063479
169Vascular calcification (HP:0004934)1.88604147
170Abnormality of transition element cation homeostasis (HP:0011030)1.87588132
171Increased serum ferritin (HP:0003281)1.87332411
172Short humerus (HP:0005792)1.87041745
173J-shaped sella turcica (HP:0002680)1.85581241
174Polyuria (HP:0000103)1.84604317
175Progressive muscle weakness (HP:0003323)1.83522475
176Abnormality of glycine metabolism (HP:0010895)1.83411059
177Abnormality of serine family amino acid metabolism (HP:0010894)1.83411059
178Thoracolumbar scoliosis (HP:0002944)1.82621830
179Interstitial pulmonary disease (HP:0006530)1.82527887
180Neonatal respiratory distress (HP:0002643)1.82131748
181Abnormal number of erythroid precursors (HP:0012131)1.81793219
182Pustule (HP:0200039)1.80861832
183Villous atrophy (HP:0011473)1.76334311
184Abnormality of small intestinal villus morphology (HP:0011472)1.76334311
185Aplasia/hypoplasia of the humerus (HP:0006507)1.74860849
186Abnormality of renal resorption (HP:0011038)1.73908549
187Hypoplasia of the radius (HP:0002984)1.72212174
188Absent radius (HP:0003974)1.71301271
189Epiphyseal stippling (HP:0010655)1.71187291
190Increased number of teeth (HP:0011069)1.70928714

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.68084666
2TLK13.82528900
3TRIB33.35175735
4BCKDK3.10148536
5FLT32.70602172
6ZAK2.61407764
7TESK12.52243568
8NME22.38857354
9PKN22.30519525
10SMG12.15980906
11SIK12.12462086
12STK162.08293955
13PIK3CG1.97240762
14MAPK151.96024341
15TBK11.95565418
16PIM21.93368838
17FGFR41.90603515
18KIT1.87723944
19ZAP701.85442546
20TAOK31.84379522
21MUSK1.80845059
22TGFBR21.70540282
23TESK21.65884361
24MAP4K11.60335908
25TYK21.57249341
26MAP3K31.53491527
27BLK1.50786871
28MAP2K31.50346440
29LRRK21.49916217
30MAP2K21.45118537
31KDR1.42903152
32PRKG21.41582017
33BTK1.38434225
34ACVR1B1.33700720
35EPHB11.31891268
36CSF1R1.31444071
37SIK21.28993107
38PTK61.27835831
39PAK41.27010263
40ARAF1.24117436
41DYRK1B1.22296473
42PBK1.19152516
43ICK1.16250349
44ABL21.13341515
45JAK31.12848298
46NEK91.11999215
47MAP3K101.11705998
48MAP3K111.11668566
49VRK21.09909999
50MAPKAPK31.08776711
51NEK21.08033764
52STK101.06637524
53IRAK21.05588734
54CDK41.03939352
55CDK120.99970645
56AURKA0.99379654
57IKBKB0.98987643
58SCYL20.92638254
59EPHA30.92479185
60MATK0.92076234
61PRKD20.92050285
62INSRR0.91075304
63IRAK30.89173818
64JAK10.86149684
65WNK40.85836570
66MYLK0.83428807
67EPHA20.83317569
68CCNB10.82937405
69GRK60.82359564
70MAP3K140.82171302
71MST1R0.80731956
72IRAK40.80678393
73ADRBK10.77871081
74RPS6KA40.76959540
75JAK20.76891291
76RPS6KC10.76595691
77RPS6KL10.76595691
78MELK0.75993037
79RPS6KA60.75810170
80TAOK20.73458480
81PTK20.71474400
82WNK30.69001920
83CSK0.67774729
84RIPK10.67354302
85PAK10.64572731
86RPS6KA20.64411941
87TTN0.63944696
88RPS6KA50.62975049
89MAPK110.62540378
90PIM10.61165611
91DDR20.59474847
92SYK0.59262517
93PRKD10.59039872
94MAPKAPK20.57852701
95MAP3K10.57730745
96CHEK20.57207316
97IRAK10.57164609
98TAOK10.56839991
99BRSK20.56644406
100IKBKE0.56292930
101LYN0.55859847
102DAPK30.55755718
103DYRK30.55067145
104MAPK120.53806720
105MAP2K60.53510050
106ADRBK20.52460649
107BUB10.50537757
108AKT20.50515623
109MAP3K80.48492462
110PRKCD0.48158112
111DAPK20.47796580
112RAF10.47422446
113MAPK40.47267811
114STK110.47171592
115EEF2K0.46942742
116MTOR0.46637086
117HCK0.46511018
118TGFBR10.46405194
119MET0.45347172
120LMTK20.45263569
121LCK0.45224604
122PDK20.45209273
123MAP2K10.45079727
124MARK30.44584249
125TEC0.44411025
126FRK0.44346122
127PAK20.43495101
128LIMK10.42144346
129TNK20.41962861
130CDK11A0.40887190
131PRPF4B0.40678308
132PDK40.40460844
133PDK30.40460844
134CHUK0.40039950
135ILK0.39544184
136CAMKK20.38688905
137PDPK10.38267881
138PLK10.37433391
139CDK150.36706341
140RPS6KB20.36172520
141BMX0.35332918
142GSK3A0.33786597
143PRKD30.33690853
144CDK60.33283912
145WNK10.31140794
146HIPK20.29488553
147CDK180.28986502
148RPS6KA10.28685039
149VRK10.26718467
150PRKCQ0.25518488
151PRKCI0.25064691
152PDK10.23885119
153CDK70.23582064
154BRAF0.22656112
155STK40.22537121

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.63219509
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.05377887
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.98305106
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.95308896
5Sulfur metabolism_Homo sapiens_hsa009202.71840045
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.69631784
7Fatty acid degradation_Homo sapiens_hsa000712.44029492
8Tryptophan metabolism_Homo sapiens_hsa003802.07021448
9Peroxisome_Homo sapiens_hsa041462.05713484
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.99905071
11Sulfur relay system_Homo sapiens_hsa041221.98208328
12Folate biosynthesis_Homo sapiens_hsa007901.98090599
13Complement and coagulation cascades_Homo sapiens_hsa046101.96464887
14Histidine metabolism_Homo sapiens_hsa003401.89684827
15Selenocompound metabolism_Homo sapiens_hsa004501.88489571
16Caffeine metabolism_Homo sapiens_hsa002321.87918284
17Staphylococcus aureus infection_Homo sapiens_hsa051501.87377649
18Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.84958459
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.84391968
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.82565281
21Other glycan degradation_Homo sapiens_hsa005111.79814384
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.73615029
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.70404930
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69226414
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.68465040
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.67901657
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.67216133
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.65680092
29RNA polymerase_Homo sapiens_hsa030201.63106819
30Fanconi anemia pathway_Homo sapiens_hsa034601.61820761
31Chemical carcinogenesis_Homo sapiens_hsa052041.61408694
32Base excision repair_Homo sapiens_hsa034101.60923082
33Butanoate metabolism_Homo sapiens_hsa006501.59323802
34Arginine biosynthesis_Homo sapiens_hsa002201.58207950
35Lysosome_Homo sapiens_hsa041421.57320381
36PPAR signaling pathway_Homo sapiens_hsa033201.54670396
37Pentose phosphate pathway_Homo sapiens_hsa000301.50840392
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.50509370
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.49847795
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.49312232
41Nitrogen metabolism_Homo sapiens_hsa009101.48232130
42beta-Alanine metabolism_Homo sapiens_hsa004101.42900151
43Propanoate metabolism_Homo sapiens_hsa006401.42103319
44Fatty acid metabolism_Homo sapiens_hsa012121.42043694
45Starch and sucrose metabolism_Homo sapiens_hsa005001.38522283
46Pyruvate metabolism_Homo sapiens_hsa006201.38438731
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34718593
48Phenylalanine metabolism_Homo sapiens_hsa003601.34715270
49Carbon metabolism_Homo sapiens_hsa012001.21888137
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19774044
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.19058780
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18035114
53Glutathione metabolism_Homo sapiens_hsa004801.16723363
54Fructose and mannose metabolism_Homo sapiens_hsa000511.15971640
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09986880
56Fat digestion and absorption_Homo sapiens_hsa049751.09512862
57Galactose metabolism_Homo sapiens_hsa000521.09327021
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.08635540
59Pyrimidine metabolism_Homo sapiens_hsa002401.07807157
60Biosynthesis of amino acids_Homo sapiens_hsa012301.06498067
61Steroid hormone biosynthesis_Homo sapiens_hsa001401.05886429
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04915182
63Steroid biosynthesis_Homo sapiens_hsa001001.03393056
64Retinol metabolism_Homo sapiens_hsa008300.98726836
65Tyrosine metabolism_Homo sapiens_hsa003500.96924757
66Bile secretion_Homo sapiens_hsa049760.96368874
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95449740
68Protein export_Homo sapiens_hsa030600.94645654
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92553825
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91170165
71Vitamin digestion and absorption_Homo sapiens_hsa049770.88983767
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88454969
73Ribosome_Homo sapiens_hsa030100.88004514
74ABC transporters_Homo sapiens_hsa020100.86133204
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85490180
76Arginine and proline metabolism_Homo sapiens_hsa003300.83409246
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.82977753
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80180449
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77307432
80Hedgehog signaling pathway_Homo sapiens_hsa043400.77174018
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73085869
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69077435
83Circadian rhythm_Homo sapiens_hsa047100.68873844
84Legionellosis_Homo sapiens_hsa051340.67903239
85Leishmaniasis_Homo sapiens_hsa051400.66028513
86Primary immunodeficiency_Homo sapiens_hsa053400.65008129
87Endocytosis_Homo sapiens_hsa041440.63855458
88Hepatitis C_Homo sapiens_hsa051600.63468920
89Homologous recombination_Homo sapiens_hsa034400.61471121
90One carbon pool by folate_Homo sapiens_hsa006700.58221608
91Glycerolipid metabolism_Homo sapiens_hsa005610.57387405
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.56837063
93Metabolic pathways_Homo sapiens_hsa011000.55390830
94Phagosome_Homo sapiens_hsa041450.54428951
95Antigen processing and presentation_Homo sapiens_hsa046120.52939580
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52321744
97Inositol phosphate metabolism_Homo sapiens_hsa005620.50620024
98VEGF signaling pathway_Homo sapiens_hsa043700.47880017
99Taste transduction_Homo sapiens_hsa047420.47536408
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46885923
101mTOR signaling pathway_Homo sapiens_hsa041500.46075212
102Basal transcription factors_Homo sapiens_hsa030220.45177000
103N-Glycan biosynthesis_Homo sapiens_hsa005100.44562612
104Lysine degradation_Homo sapiens_hsa003100.43204288
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.42700035
106Renin-angiotensin system_Homo sapiens_hsa046140.42580535
107Fatty acid elongation_Homo sapiens_hsa000620.42345927
108Pertussis_Homo sapiens_hsa051330.42296810
109Regulation of autophagy_Homo sapiens_hsa041400.42127954
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41857068
111Arachidonic acid metabolism_Homo sapiens_hsa005900.41567116
112Ovarian steroidogenesis_Homo sapiens_hsa049130.41528395
113Malaria_Homo sapiens_hsa051440.41342564
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.41063344
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41017439
116DNA replication_Homo sapiens_hsa030300.40609926
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40092702
118Notch signaling pathway_Homo sapiens_hsa043300.38687063
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37458957
120Osteoclast differentiation_Homo sapiens_hsa043800.37270719
121Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36118231
122Linoleic acid metabolism_Homo sapiens_hsa005910.35374963
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35279566
124Sphingolipid metabolism_Homo sapiens_hsa006000.34492187
125Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34082410
126Purine metabolism_Homo sapiens_hsa002300.33316856
127TNF signaling pathway_Homo sapiens_hsa046680.33258907
128Tuberculosis_Homo sapiens_hsa051520.32753522
129Bladder cancer_Homo sapiens_hsa052190.32181553
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.31889078
131Mineral absorption_Homo sapiens_hsa049780.31046751
132Insulin resistance_Homo sapiens_hsa049310.30962693
133Acute myeloid leukemia_Homo sapiens_hsa052210.30910000
134Apoptosis_Homo sapiens_hsa042100.30749034
135Systemic lupus erythematosus_Homo sapiens_hsa053220.29888708
136NF-kappa B signaling pathway_Homo sapiens_hsa040640.28668939
137Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28088192
138Huntingtons disease_Homo sapiens_hsa050160.26836017
139Toll-like receptor signaling pathway_Homo sapiens_hsa046200.25294206
140Cell cycle_Homo sapiens_hsa041100.25064987
141Hematopoietic cell lineage_Homo sapiens_hsa046400.25061475
142Nucleotide excision repair_Homo sapiens_hsa034200.24798799
143Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22680740
144Herpes simplex infection_Homo sapiens_hsa051680.22469389
145Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22112144
146Alcoholism_Homo sapiens_hsa050340.21269947
147Viral carcinogenesis_Homo sapiens_hsa052030.19164190
148Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19034831
149Hepatitis B_Homo sapiens_hsa051610.18584129
150Influenza A_Homo sapiens_hsa051640.17915855
151p53 signaling pathway_Homo sapiens_hsa041150.16726451
152HTLV-I infection_Homo sapiens_hsa051660.16215300
153Basal cell carcinoma_Homo sapiens_hsa052170.15461748
154B cell receptor signaling pathway_Homo sapiens_hsa046620.15022358
155Jak-STAT signaling pathway_Homo sapiens_hsa046300.14237129

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