SPTB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes a member of the spectrin gene family. Spectrin proteins, along with ankyrin, play a role in cell membrane organization and stability. The protein encoded by this locus functions in stability of erythrocyte membranes, and mutations in this gene have been associated with spherocytosis type 2, hereditary elliptocytosis, and neonatal hemolytic anemia. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)9.45436747
2actin-myosin filament sliding (GO:0033275)9.45436747
3protoporphyrinogen IX metabolic process (GO:0046501)8.48893867
4actin-mediated cell contraction (GO:0070252)7.66790777
5oxygen transport (GO:0015671)7.29222605
6skeletal muscle contraction (GO:0003009)7.02539014
7protoporphyrinogen IX biosynthetic process (GO:0006782)6.99264747
8gas transport (GO:0015669)6.91830561
9regulation of skeletal muscle contraction (GO:0014819)6.88389712
10regulation of relaxation of muscle (GO:1901077)6.51556737
11striated muscle contraction (GO:0006941)6.25842474
12response to stimulus involved in regulation of muscle adaptation (GO:0014874)6.02697149
13* porphyrin-containing compound biosynthetic process (GO:0006779)5.84556646
14response to inactivity (GO:0014854)5.73476510
15actin filament-based movement (GO:0030048)5.63085690
16creatine metabolic process (GO:0006600)5.31229902
17* tetrapyrrole biosynthetic process (GO:0033014)5.21470815
18sodium ion export (GO:0071436)5.09557494
19receptor recycling (GO:0001881)5.03056369
20heme biosynthetic process (GO:0006783)4.94642841
21response to methylmercury (GO:0051597)4.88405198
22locomotory exploration behavior (GO:0035641)4.67813509
23synaptic vesicle maturation (GO:0016188)4.66304573
24regulation of short-term neuronal synaptic plasticity (GO:0048172)4.62734022
25cardiac muscle hypertrophy (GO:0003300)4.55645593
26actomyosin structure organization (GO:0031032)4.52212124
27erythrocyte development (GO:0048821)4.51548426
28skeletal muscle adaptation (GO:0043501)4.51148480
29regulation of actin filament-based movement (GO:1903115)4.44497598
30cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.40828920
31striated muscle hypertrophy (GO:0014897)4.38136479
32muscle contraction (GO:0006936)4.35271822
33* porphyrin-containing compound metabolic process (GO:0006778)4.34215878
34regulation of ARF protein signal transduction (GO:0032012)4.28723854
35response to insecticide (GO:0017085)4.26733489
36skeletal muscle fiber development (GO:0048741)4.22727282
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.17901077
38positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.14248010
39positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.10836787
40regulation of response to osmotic stress (GO:0047484)4.10235743
41cerebellar Purkinje cell differentiation (GO:0021702)4.05453081
42erythrocyte maturation (GO:0043249)4.02120182
43myotube cell development (GO:0014904)3.96694591
44muscle system process (GO:0003012)3.94766030
45muscle hypertrophy (GO:0014896)3.90422120
46cell communication by electrical coupling (GO:0010644)3.90119520
47striated muscle adaptation (GO:0014888)3.89126777
48response to muscle activity (GO:0014850)3.88416752
49negative regulation of organelle assembly (GO:1902116)3.81494148
50vocalization behavior (GO:0071625)3.80615694
51regulation of synapse structural plasticity (GO:0051823)3.79303835
52iron ion import (GO:0097286)3.76151299
53neuronal action potential propagation (GO:0019227)3.76059743
54glycine transport (GO:0015816)3.74224953
55cellular potassium ion homeostasis (GO:0030007)3.71401888
56regulation of striated muscle contraction (GO:0006942)3.65625936
57ionotropic glutamate receptor signaling pathway (GO:0035235)3.65116217
58positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.64964857
59regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.63568903
60regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.58546026
61activation of protein kinase A activity (GO:0034199)3.58478287
62positive regulation of fibroblast migration (GO:0010763)3.57731350
63cytoskeletal anchoring at plasma membrane (GO:0007016)3.54547001
64heme metabolic process (GO:0042168)3.54544400
65regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.51357531
66synaptic vesicle docking involved in exocytosis (GO:0016081)3.50714794
67potassium ion import (GO:0010107)3.43760511
68myeloid cell development (GO:0061515)3.43025213
69plasma membrane repair (GO:0001778)3.41610992
70skeletal muscle tissue regeneration (GO:0043403)3.41274409
71muscle fiber development (GO:0048747)3.40884035
72negative regulation of erythrocyte differentiation (GO:0045647)3.38230834
73striated muscle atrophy (GO:0014891)3.38201305
74regulation of synaptic vesicle exocytosis (GO:2000300)3.38155985
75regulation of glutamate receptor signaling pathway (GO:1900449)3.37961132
76positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.37878965
77cardiac muscle hypertrophy in response to stress (GO:0014898)3.33514503
78muscle hypertrophy in response to stress (GO:0003299)3.33514503
79cardiac muscle adaptation (GO:0014887)3.33514503
80synaptic vesicle exocytosis (GO:0016079)3.31927670
81regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.31446842
82cell communication involved in cardiac conduction (GO:0086065)3.30857682
83skeletal muscle tissue development (GO:0007519)3.30849468
84regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.30806207
85membrane depolarization during action potential (GO:0086010)3.29416133
86neuromuscular process controlling balance (GO:0050885)3.29123388
87cardiac muscle contraction (GO:0060048)3.28122792
88adult heart development (GO:0007512)3.27730407
89negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.27587076
90glutamate secretion (GO:0014047)3.27325644
91positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.26369540
92regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.25947415
93cellular response to dexamethasone stimulus (GO:0071549)3.23262400
94carnitine transmembrane transport (GO:1902603)3.23078755
95glycogen catabolic process (GO:0005980)3.21837951
96long-term memory (GO:0007616)3.21337445
97negative regulation of potassium ion transport (GO:0043267)3.20128323
98negative regulation of potassium ion transmembrane transport (GO:1901380)3.19657952
99regulation of long-term neuronal synaptic plasticity (GO:0048169)3.19417010
100cardiac myofibril assembly (GO:0055003)3.18716505
101regulation of synaptic vesicle transport (GO:1902803)3.16828946
102positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.16609220
103muscle adaptation (GO:0043500)3.16278945
104neurotransmitter secretion (GO:0007269)3.15780103
105regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.15560720
106regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.14768444
107glutamate receptor signaling pathway (GO:0007215)3.13909168
108platelet formation (GO:0030220)3.12855278
109carnitine shuttle (GO:0006853)3.12340822
110regulation of neuronal synaptic plasticity (GO:0048168)3.11302366
111hemoglobin metabolic process (GO:0020027)3.10907236
112muscle tissue morphogenesis (GO:0060415)3.10828325
113regulation of calcium ion transmembrane transporter activity (GO:1901019)3.10127972
114regulation of calcium ion transmembrane transport (GO:1903169)3.10127972
115exploration behavior (GO:0035640)3.09543658
116positive regulation of myotube differentiation (GO:0010831)3.08575889
117regulation of membrane repolarization (GO:0060306)3.08387295
118glucan catabolic process (GO:0009251)3.07897225
119sarcoplasmic reticulum calcium ion transport (GO:0070296)3.06629357
120myofibril assembly (GO:0030239)3.06122537
121positive regulation of synapse maturation (GO:0090129)3.05761945
122cardiac muscle tissue morphogenesis (GO:0055008)3.05011881
123fatty acid transmembrane transport (GO:1902001)3.04984314
124neuromuscular process controlling posture (GO:0050884)3.03233249
125response to epinephrine (GO:0071871)3.01047660
126* tetrapyrrole metabolic process (GO:0033013)3.00991014
127import into cell (GO:0098657)3.00249112
128synaptic transmission, glutamatergic (GO:0035249)2.99953422
129sarcomere organization (GO:0045214)2.99754974
130positive regulation of potassium ion transmembrane transport (GO:1901381)2.99222159
131gamma-aminobutyric acid transport (GO:0015812)2.96583544
132protein targeting to plasma membrane (GO:0072661)2.95906047
133cardiac muscle cell development (GO:0055013)2.95463753
134glucan biosynthetic process (GO:0009250)2.95096447
135glycogen biosynthetic process (GO:0005978)2.95096447
136response to dexamethasone (GO:0071548)2.94877248
137NADH metabolic process (GO:0006734)2.94210570
138muscle cell cellular homeostasis (GO:0046716)2.93305710
139cerebellar granule cell differentiation (GO:0021707)2.92838428
140layer formation in cerebral cortex (GO:0021819)2.92746638
141negative regulation of calcium ion transmembrane transport (GO:1903170)2.92088699
142negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.92088699
143regulation of the force of heart contraction (GO:0002026)2.90992912
144cellular response to epinephrine stimulus (GO:0071872)2.90288379
145amino-acid betaine transport (GO:0015838)2.89947496
146carnitine transport (GO:0015879)2.89947496
147negative regulation of cytosolic calcium ion concentration (GO:0051481)2.89708394
148negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.88666446
149erythrocyte differentiation (GO:0030218)2.88008929
150* actin filament capping (GO:0051693)2.86601772
151regulation of cell communication by electrical coupling (GO:0010649)2.86195759
152response to lead ion (GO:0010288)2.82057033
153regulation of excitatory postsynaptic membrane potential (GO:0060079)2.81977591
154neuron-neuron synaptic transmission (GO:0007270)2.81336158
155bicarbonate transport (GO:0015701)2.80701854
156synaptic vesicle endocytosis (GO:0048488)2.79430340
157neurotransmitter-gated ion channel clustering (GO:0072578)2.76555541
158cell differentiation in hindbrain (GO:0021533)2.75377601
159regulation of cAMP-dependent protein kinase activity (GO:2000479)2.74528523
160regulation of clathrin-mediated endocytosis (GO:2000369)2.73372913
161protein localization to synapse (GO:0035418)2.71390453

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human5.83637127
2GATA1_19941826_ChIP-Seq_K562_Human4.15426417
3EZH2_22144423_ChIP-Seq_EOC_Human4.05792170
4GATA1_19941827_ChIP-Seq_MEL_Mouse3.34147424
5TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse3.01968709
6KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse2.94226940
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.91179198
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.73076382
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.55369464
10DROSHA_22980978_ChIP-Seq_HELA_Human2.38038238
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.37188098
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.36430968
13KDM2B_26808549_Chip-Seq_K562_Human2.22030830
14* GATA2_19941826_ChIP-Seq_K562_Human2.19544407
15IKZF1_21737484_ChIP-ChIP_HCT116_Human2.18817809
16EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.09976277
17ZNF263_19887448_ChIP-Seq_K562_Human2.06523696
18GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.02697660
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.99555486
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.98949725
21REST_21632747_ChIP-Seq_MESCs_Mouse1.96953490
22JARID2_20064375_ChIP-Seq_MESCs_Mouse1.91032367
23KDM2B_26808549_Chip-Seq_SUP-B15_Human1.88177810
24KDM2B_26808549_Chip-Seq_DND41_Human1.88141049
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.87285382
26* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.86555167
27SCL_19346495_ChIP-Seq_HPC-7_Human1.84223309
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82600154
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.80417529
30ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.79032271
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.75504492
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.72651539
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72317465
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72317465
35* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.70055627
36* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.65889807
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.62548047
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59209967
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.58043051
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55776543
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50248100
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.48782377
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46915235
44* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44987120
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44957397
46GATA1_22383799_ChIP-Seq_G1ME_Mouse1.43312958
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39831804
48KDM2B_26808549_Chip-Seq_JURKAT_Human1.38448151
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.36955958
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35499169
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34327453
52ZFP281_18757296_ChIP-ChIP_E14_Mouse1.31181040
53SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.29079347
54LXR_22292898_ChIP-Seq_THP-1_Human1.25666392
55CREB1_26743006_Chip-Seq_LNCaP_Human1.23421156
56GATA4_21415370_ChIP-Seq_HL-1_Mouse1.23330759
57PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.22842303
58SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.22349200
59IGF1R_20145208_ChIP-Seq_DFB_Human1.21797476
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21026347
61TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.19994623
62EZH2_27304074_Chip-Seq_ESCs_Mouse1.19919813
63TCF7_22412390_ChIP-Seq_EML_Mouse1.19693093
64LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18260029
65EED_16625203_ChIP-ChIP_MESCs_Mouse1.17749244
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17649453
67WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17320399
68CTCF_27219007_Chip-Seq_Bcells_Human1.15691047
69P68_20966046_ChIP-Seq_HELA_Human1.15666186
70DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14532937
71CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14358886
72GATA1_19941827_ChIP-Seq_MEL86_Mouse1.12795474
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12297367
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12029688
75TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10337742
76AR_19668381_ChIP-Seq_PC3_Human1.09761480
77NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.09164362
78RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08843207
79OCT4_19829295_ChIP-Seq_ESCs_Human1.08370094
80SPI1_23127762_ChIP-Seq_K562_Human1.08163104
81WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08055013
82CTCF_21964334_ChIP-Seq_BJAB-B_Human1.06277485
83CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04342506
84ELF1_20517297_ChIP-Seq_JURKAT_Human1.03863931
85GBX2_23144817_ChIP-Seq_PC3_Human1.02939496
86CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02007877
87ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01958022
88CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01690972
89RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01641613
90MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.01158289
91TBX20_22080862_ChIP-Seq_HEART_Mouse1.00842153
92TBX20_22328084_ChIP-Seq_HEART_Mouse1.00842153
93SMC4_20622854_ChIP-Seq_HELA_Human0.99927739
94ESR1_20079471_ChIP-ChIP_T-47D_Human0.98410654
95SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98306901
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97692277
97AR_21572438_ChIP-Seq_LNCaP_Human0.97399146
98SPI1_20517297_ChIP-Seq_HL60_Human0.97257715
99RING1B_27294783_Chip-Seq_ESCs_Mouse0.95440604
100MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.95002310
101BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94657900
102HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94149570
103EP300_21415370_ChIP-Seq_HL-1_Mouse0.93504096
104NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.93443631
105SOX2_21211035_ChIP-Seq_LN229_Gbm0.92874813
106NCOR1_26117541_ChIP-Seq_K562_Human0.92474960
107TET1_21490601_ChIP-Seq_MESCs_Mouse0.91947090
108SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91898383
109* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.90188296
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90082941
111NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89963924
112TDRD3_21172665_ChIP-Seq_MCF-7_Human0.88965084
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86697920
114NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.86111408
115P300_27058665_Chip-Seq_ZR-75-30cells_Human0.85946626
116MYC_22102868_ChIP-Seq_BL_Human0.84874557
117GATA1_26923725_Chip-Seq_HPCs_Mouse0.83771343
118GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.83129667
119GATA2_22383799_ChIP-Seq_G1ME_Mouse0.81065918
120CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80058215
121TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79514192
122* FOXM1_23109430_ChIP-Seq_U2OS_Human0.79185033
123YAP1_20516196_ChIP-Seq_MESCs_Mouse0.77669495
124GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.75049323
125ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.74340821
126MAF_26560356_Chip-Seq_TH1_Human0.74071996
127GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.73802367
128SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.72726706
129GF1_26923725_Chip-Seq_HPCs_Mouse0.72202918
130OCT1_27270436_Chip-Seq_PROSTATE_Human0.71878740
131SMAD4_21741376_ChIP-Seq_ESCs_Human0.70460597
132* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.69998578
133MYC_27129775_Chip-Seq_CORNEA_Mouse0.69203117
134LXR_22158963_ChIP-Seq_LIVER_Mouse0.69158983
135DPY_21335234_ChIP-Seq_ESCs_Mouse0.69032647
136CTCF_21964334_Chip-Seq_Bcells_Human0.67924415

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo6.15928154
2MP0004859_abnormal_synaptic_plasticity5.42332025
3MP0004147_increased_porphyrin_level5.28562070
4MP0003646_muscle_fatigue3.03979853
5MP0002837_dystrophic_cardiac_calcinosis2.95353918
6MP0003635_abnormal_synaptic_transmissio2.88204104
7MP0000751_myopathy2.80312367
8MP0004215_abnormal_myocardial_fiber2.69893278
9MP0000749_muscle_degeneration2.52877143
10MP0005451_abnormal_body_composition2.52692037
11MP0009046_muscle_twitch2.52540599
12MP0004145_abnormal_muscle_electrophysio2.51271510
13MP0002822_catalepsy2.41648975
14MP0004084_abnormal_cardiac_muscle2.32332988
15MP0009745_abnormal_behavioral_response2.31553772
16MP0005083_abnormal_biliary_tract2.29108763
17MP0002064_seizures2.21898510
18MP0008569_lethality_at_weaning2.16845565
19MP0002063_abnormal_learning/memory/cond2.14864537
20MP0004270_analgesia2.14130814
21MP0003880_abnormal_central_pattern2.10567090
22MP0004036_abnormal_muscle_relaxation2.03994103
23MP0008775_abnormal_heart_ventricle2.01155713
24MP0001440_abnormal_grooming_behavior1.84143942
25MP0002272_abnormal_nervous_system1.80453285
26MP0001968_abnormal_touch/_nociception1.79943471
27MP0000747_muscle_weakness1.69835571
28MP0002734_abnormal_mechanical_nocicepti1.68829712
29MP0004484_altered_response_of1.65214480
30MP0004087_abnormal_muscle_fiber1.62956984
31MP0005423_abnormal_somatic_nervous1.61652916
32MP0002572_abnormal_emotion/affect_behav1.61408804
33MP0004130_abnormal_muscle_cell1.60317556
34MP0003137_abnormal_impulse_conducting1.58615121
35MP0005620_abnormal_muscle_contractility1.58323816
36MP0005330_cardiomyopathy1.55627059
37MP0004510_myositis1.55079452
38MP0004085_abnormal_heartbeat1.51981854
39MP0002972_abnormal_cardiac_muscle1.45581719
40MP0002067_abnormal_sensory_capabilities1.44908681
41MP0002909_abnormal_adrenal_gland1.44885824
42MP0002735_abnormal_chemical_nociception1.43087986
43MP0002269_muscular_atrophy1.42605121
44MP0001486_abnormal_startle_reflex1.41403020
45MP0002106_abnormal_muscle_physiology1.40191133
46MP0003879_abnormal_hair_cell1.39739515
47MP0008872_abnormal_physiological_respon1.38467943
48MP0000759_abnormal_skeletal_muscle1.37704591
49MP0004811_abnormal_neuron_physiology1.36503112
50MP0002108_abnormal_muscle_morphology1.35426671
51MP0002736_abnormal_nociception_after1.34270182
52MP0003045_fibrosis1.34167375
53MP0000733_abnormal_muscle_development1.32537998
54MP0001661_extended_life_span1.27507316
55MP0003787_abnormal_imprinting1.27010913
56MP0005386_behavior/neurological_phenoty1.26473617
57MP0004924_abnormal_behavior1.26473617
58MP0001970_abnormal_pain_threshold1.24150858
59MP0000013_abnormal_adipose_tissue1.21107529
60MP0004233_abnormal_muscle_weight1.19522592
61MP0003329_amyloid_beta_deposits1.18978555
62MP0004885_abnormal_endolymph1.18819523
63MP0005266_abnormal_metabolism1.17863675
64MP0002127_abnormal_cardiovascular_syste1.17141835
65MP0002733_abnormal_thermal_nociception1.16205540
66MP0005369_muscle_phenotype1.13389569
67MP0008961_abnormal_basal_metabolism1.12497168
68MP0003633_abnormal_nervous_system1.11335045
69MP0003950_abnormal_plasma_membrane1.08521339
70MP0002066_abnormal_motor_capabilities/c1.07518769
71MP0003221_abnormal_cardiomyocyte_apopto1.07418159
72MP0001501_abnormal_sleep_pattern1.06333699
73MP0009780_abnormal_chondrocyte_physiolo1.05353130
74MP0005385_cardiovascular_system_phenoty0.98852038
75MP0001544_abnormal_cardiovascular_syste0.98852038
76MP0000955_abnormal_spinal_cord0.98381850
77MP0002332_abnormal_exercise_endurance0.97510766
78MP0008770_decreased_survivor_rate0.96512493
79MP0003631_nervous_system_phenotype0.94227485
80MP0002229_neurodegeneration0.92456184
81MP0010630_abnormal_cardiac_muscle0.91859960
82MP0002557_abnormal_social/conspecific_i0.91805312
83MP0006036_abnormal_mitochondrial_physio0.90449727
84MP0002971_abnormal_brown_adipose0.88610416
85MP0006138_congestive_heart_failure0.88423406
86MP0002184_abnormal_innervation0.88322866
87MP0002882_abnormal_neuron_morphology0.87837543
88MP0004858_abnormal_nervous_system0.85593206
89MP0000003_abnormal_adipose_tissue0.83676190
90MP0006276_abnormal_autonomic_nervous0.82893703
91MP0004043_abnormal_pH_regulation0.82470240
92MP0001529_abnormal_vocalization0.80883095
93MP0004142_abnormal_muscle_tone0.80081352
94MP0005397_hematopoietic_system_phenotyp0.78573520
95MP0001545_abnormal_hematopoietic_system0.78573520
96MP0000750_abnormal_muscle_regeneration0.76172757
97MP0003075_altered_response_to0.74078473
98MP0002152_abnormal_brain_morphology0.72133691
99MP0008874_decreased_physiological_sensi0.69840933
100MP0005535_abnormal_body_temperature0.67609446
101MP0005167_abnormal_blood-brain_barrier0.64896547
102MP0005636_abnormal_mineral_homeostasis0.64543191
103MP0005310_abnormal_salivary_gland0.63235266
104MP0005666_abnormal_adipose_tissue0.62780970
105MP0000920_abnormal_myelination0.61561454
106MP0005646_abnormal_pituitary_gland0.61332076
107MP0000266_abnormal_heart_morphology0.61047439
108MP0003632_abnormal_nervous_system0.60941071
109MP0005375_adipose_tissue_phenotype0.60750901
110MP0003283_abnormal_digestive_organ0.59441629
111MP0004185_abnormal_adipocyte_glucose0.57931728
112MP0002090_abnormal_vision0.57373367
113MP0002877_abnormal_melanocyte_morpholog0.56966553
114MP0003828_pulmonary_edema0.55952147
115MP0009278_abnormal_bone_marrow0.53735975
116MP0008260_abnormal_autophagy0.51554725
117MP0008995_early_reproductive_senescence0.50482538
118MP0002638_abnormal_pupillary_reflex0.50036240
119MP0006035_abnormal_mitochondrial_morpho0.47205813
120MP0002078_abnormal_glucose_homeostasis0.46815875
121MP0003303_peritoneal_inflammation0.43541304
122MP0005187_abnormal_penis_morphology0.42444511
123MP0000372_irregular_coat_pigmentation0.38187571
124MP0001986_abnormal_taste_sensitivity0.35471221
125MP0005452_abnormal_adipose_tissue0.34814375
126MP0005670_abnormal_white_adipose0.33476161
127MP0002128_abnormal_blood_circulation0.31185634
128MP0005584_abnormal_enzyme/coenzyme_acti0.30283263
129MP0003948_abnormal_gas_homeostasis0.28032757

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)9.12349173
2Muscle fiber inclusion bodies (HP:0100299)8.91206948
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)8.81999227
4* Poikilocytosis (HP:0004447)6.92560047
5Type 1 muscle fiber predominance (HP:0003803)6.88879351
6Abnormality of the heme biosynthetic pathway (HP:0010472)6.79038175
7Reticulocytosis (HP:0001923)6.33704718
8Distal arthrogryposis (HP:0005684)5.88577812
9Acanthocytosis (HP:0001927)5.75639434
10Myopathic facies (HP:0002058)5.30292744
11Focal seizures (HP:0007359)4.52049905
12Cholelithiasis (HP:0001081)4.47611833
13Round ear (HP:0100830)4.36086746
14Ulnar deviation of the wrist (HP:0003049)4.26687971
15Febrile seizures (HP:0002373)4.23215580
16Myokymia (HP:0002411)4.15413967
17Sudden death (HP:0001699)3.99146173
18Increased connective tissue (HP:0009025)3.98778948
19Exercise-induced myalgia (HP:0003738)3.96273964
20Focal motor seizures (HP:0011153)3.96199772
21Abnormal gallbladder morphology (HP:0012437)3.92815301
22Centrally nucleated skeletal muscle fibers (HP:0003687)3.84955675
23Diaphragmatic weakness (HP:0009113)3.82378586
24Insomnia (HP:0100785)3.81782800
25Poor eye contact (HP:0000817)3.77527647
26Rhabdomyolysis (HP:0003201)3.75911283
27Epileptic encephalopathy (HP:0200134)3.71743806
28Neck muscle weakness (HP:0000467)3.69024112
29Dysmetric saccades (HP:0000641)3.68293060
30Calcaneovalgus deformity (HP:0001848)3.56580597
31Abnormal social behavior (HP:0012433)3.54671391
32Impaired social interactions (HP:0000735)3.54671391
33Abnormality of skeletal muscle fiber size (HP:0012084)3.53141616
34Visual hallucinations (HP:0002367)3.52932558
35Exercise-induced muscle cramps (HP:0003710)3.49996239
36Generalized tonic-clonic seizures (HP:0002069)3.47999164
37Depression (HP:0000716)3.42750117
38Fetal akinesia sequence (HP:0001989)3.42242471
39Rimmed vacuoles (HP:0003805)3.38475625
40Hemiparesis (HP:0001269)3.33508200
41Paralysis (HP:0003470)3.29258496
42Bundle branch block (HP:0011710)3.27962540
43Malignant hyperthermia (HP:0002047)3.23634150
44Action tremor (HP:0002345)3.22531962
45Abnormality of reticulocytes (HP:0004312)3.22036292
46Ventricular fibrillation (HP:0001663)3.18567157
47Calf muscle hypertrophy (HP:0008981)3.18359014
48Status epilepticus (HP:0002133)3.17954185
49Frequent falls (HP:0002359)3.15664506
50Deformed tarsal bones (HP:0008119)3.09557361
51Muscle hypertrophy of the lower extremities (HP:0008968)3.09299557
52Absent phalangeal crease (HP:0006109)3.03267257
53Lower limb amyotrophy (HP:0007210)2.94665169
54Polycythemia (HP:0001901)2.93694587
55Hypochromic microcytic anemia (HP:0004840)2.91580618
56Dysdiadochokinesis (HP:0002075)2.85914664
57Distal lower limb muscle weakness (HP:0009053)2.81584060
58Atrial fibrillation (HP:0005110)2.81095927
59Postural instability (HP:0002172)2.79548594
60Areflexia of lower limbs (HP:0002522)2.79178307
61Hyperkalemia (HP:0002153)2.77021356
62Muscle stiffness (HP:0003552)2.71370234
63Generalized muscle weakness (HP:0003324)2.70508589
64Anxiety (HP:0000739)2.69776257
65Progressive cerebellar ataxia (HP:0002073)2.69284882
66Difficulty running (HP:0009046)2.68629058
67Primary atrial arrhythmia (HP:0001692)2.68245998
68Prolonged QT interval (HP:0001657)2.67532231
69Abnormality of the calf musculature (HP:0001430)2.65442032
70Hyporeflexia of lower limbs (HP:0002600)2.59669263
71Abnormality of the left ventricular outflow tract (HP:0011103)2.56230022
72Subaortic stenosis (HP:0001682)2.56230022
73Supraventricular tachycardia (HP:0004755)2.54434746
74Abnormal finger flexion creases (HP:0006143)2.50750200
75Resting tremor (HP:0002322)2.50468084
76Abnormality of the gallbladder (HP:0005264)2.49876844
77Asymmetric septal hypertrophy (HP:0001670)2.49870077
78Gaze-evoked nystagmus (HP:0000640)2.48617940
79EMG: myopathic abnormalities (HP:0003458)2.47922365
80Supraventricular arrhythmia (HP:0005115)2.47244138
81Myotonia (HP:0002486)2.46158695
82Truncal ataxia (HP:0002078)2.44776998
83Cholecystitis (HP:0001082)2.41917006
84Abnormal gallbladder physiology (HP:0012438)2.41917006
85Microcytic anemia (HP:0001935)2.41490321
86Myoglobinuria (HP:0002913)2.39489339
87Abnormal hemoglobin (HP:0011902)2.37529035
88Long clavicles (HP:0000890)2.37078513
89Dilated cardiomyopathy (HP:0001644)2.36336411
90Muscle fiber splitting (HP:0003555)2.34305011
91Syncope (HP:0001279)2.33757971
92Toxemia of pregnancy (HP:0100603)2.32840148
93Diplopia (HP:0000651)2.31826484
94Abnormality of binocular vision (HP:0011514)2.31826484
95Abnormality of the foot musculature (HP:0001436)2.29572268
96Abnormal EKG (HP:0003115)2.28280421
97Lipoatrophy (HP:0100578)2.28003925
98Abnormality of the calcaneus (HP:0008364)2.27796433
99Heart block (HP:0012722)2.26978209
100Mildly elevated creatine phosphokinase (HP:0008180)2.26110158
101Ankle clonus (HP:0011448)2.25580931
102Bulbar palsy (HP:0001283)2.24789124
103Foot dorsiflexor weakness (HP:0009027)2.23563689
104Absence seizures (HP:0002121)2.23426828
105Abnormality of the neuromuscular junction (HP:0003398)2.23184336
106Fatigable weakness (HP:0003473)2.23184336
107Abnormality of the lower motor neuron (HP:0002366)2.23139464
108Impaired smooth pursuit (HP:0007772)2.22514663
109Abnormal atrioventricular conduction (HP:0005150)2.21271216
110Ventricular arrhythmia (HP:0004308)2.21225896
111Global brain atrophy (HP:0002283)2.17989352
112Atonic seizures (HP:0010819)2.16491672
113Dysmetria (HP:0001310)2.16005901
114Dialeptic seizures (HP:0011146)2.12181843
115Intention tremor (HP:0002080)2.11176733
116Urinary bladder sphincter dysfunction (HP:0002839)2.10983055
117Impaired vibration sensation in the lower limbs (HP:0002166)2.10770664
118Broad-based gait (HP:0002136)2.10502571
119Ventricular tachycardia (HP:0004756)2.10320625
120Weak cry (HP:0001612)2.09398740
121* Hyperbilirubinemia (HP:0002904)2.08399908
122Heterotopia (HP:0002282)2.05784487
123Supranuclear gaze palsy (HP:0000605)2.05609034
124Abnormality of ocular smooth pursuit (HP:0000617)2.04786140
125Gowers sign (HP:0003391)2.04342578
126Bilateral sensorineural hearing impairment (HP:0008619)2.02898832
127Increased variability in muscle fiber diameter (HP:0003557)2.02358820
128Bradykinesia (HP:0002067)2.01003532
129Osteomalacia (HP:0002749)1.99759218
130Distal lower limb amyotrophy (HP:0008944)1.99469247
131Severe muscular hypotonia (HP:0006829)1.98907207
132Tetraparesis (HP:0002273)1.98669059
133Atrioventricular block (HP:0001678)1.97697764
134Slender build (HP:0001533)1.96965393
135Hemiplegia (HP:0002301)1.94620347
136Muscular dystrophy (HP:0003560)1.94427353
137Scapular winging (HP:0003691)1.91632165
138EMG: neuropathic changes (HP:0003445)1.89074712
139Difficulty climbing stairs (HP:0003551)1.89053208
140Hypochromic anemia (HP:0001931)1.88553212
141Urinary urgency (HP:0000012)1.88449675
142Popliteal pterygium (HP:0009756)1.87045587
143Impaired vibratory sensation (HP:0002495)1.79338283
144Scanning speech (HP:0002168)1.78860135
145Childhood onset (HP:0011463)1.77123889
146Petechiae (HP:0000967)1.76471552
147Hip contracture (HP:0003273)1.75890315
148Nonprogressive disorder (HP:0003680)1.74772136
149Annular pancreas (HP:0001734)1.74534805
150Ileus (HP:0002595)1.67177708
151Metatarsus adductus (HP:0001840)1.66088200
152Type 2 muscle fiber atrophy (HP:0003554)1.64040918
153Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.59865303
154Proximal amyotrophy (HP:0007126)1.58928636

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.03468224
2EPHA42.74614719
3MAP2K32.71591053
4EIF2AK12.49659570
5DAPK22.33870496
6PHKG22.27970833
7PHKG12.27970833
8TAOK12.18854120
9MAP3K92.14311517
10TRIB32.09827928
11PIK3CG2.09312448
12CAMKK12.03531440
13MAP3K41.92718150
14PRKD31.86336217
15OBSCN1.77688922
16TRPM71.77505364
17LMTK21.76472933
18TTN1.74450952
19PAK61.70632787
20SGK31.70326675
21MINK11.64208316
22NEK11.62564301
23STK41.62159311
24RIPK11.62090383
25KSR21.61407839
26TAOK21.59026720
27STK381.57333694
28PINK11.49130371
29WNK11.48425778
30MUSK1.47338945
31SGK21.40919933
32RIPK41.36571395
33MAP2K41.32384433
34DMPK1.31855611
35SGK2231.30221726
36SGK4941.30221726
37PKN21.27884209
38CDK51.23968482
39BRSK11.23018330
40CAMKK21.20397606
41SGK11.20387703
42PRPF4B1.18301054
43CDC42BPA1.17083387
44PRKAA11.12836052
45MAP3K71.12702176
46NTRK11.08955629
47MARK11.07728355
48GRK51.04498451
49PRKCH1.04230666
50RET1.03928844
51SIK21.03524283
52NTRK21.03489002
53ALK1.02054004
54BMX1.01593852
55PDPK11.00636376
56EEF2K1.00424990
57CAMK10.97990642
58SCYL20.97765582
59UHMK10.97338729
60PDK10.97004271
61STK110.96192832
62CCNB10.96119029
63ICK0.93236401
64PTK2B0.92589943
65MAP2K70.88041073
66CAMK40.86848087
67RPS6KA30.85572886
68TNK20.82638657
69MAP3K30.79904876
70MAPKAPK30.79822527
71NME10.79764497
72KSR10.78855784
73DYRK1B0.78297411
74RPS6KA20.75270807
75DAPK10.72732396
76MAPK110.70216133
77CAMK1G0.69596886
78MAPK120.69253552
79CDK150.66968462
80PIM10.66309070
81PRKCG0.65112182
82JAK20.64905241
83CDK190.64575151
84AKT20.64508525
85MAP3K20.64404106
86MAP3K10.63581212
87ROCK10.62990640
88MAP3K130.62292181
89CDK180.62150773
90MAP2K60.62058736
91CDK120.59018454
92MARK30.58597302
93SYK0.58339009
94CDK140.58265156
95CDK11A0.57950978
96DAPK30.57539534
97CAMK2G0.57473575
98PRKD20.57449735
99MAP3K100.56994397
100RPS6KA50.56329392
101ERBB20.56002253
102PRKACG0.54713921
103RAF10.54713399
104MOS0.54312725
105MAPK130.54197101
106PRKAA20.53711591
107MARK20.53309017
108PDK40.52585791
109PDK30.52585791
110PRKD10.51758406
111MAP2K10.51495085
112TLK10.50672093
113TYRO30.50659740
114MAPK100.49785723
115ROCK20.49115432
116CAMK2A0.49044360
117ZAK0.47215285
118RPS6KL10.47102570
119MAP3K110.46974586
120RPS6KC10.46661867
121HIPK20.45255485
122BRAF0.44582132
123MAP3K50.43209691
124MAP3K60.42616830
125RPS6KA60.42536028
126RPS6KB10.42290291
127MAPK40.41866082
128PRKG10.40604613
129PKN10.40154679
130CAMK2D0.40144107
131PIK3CA0.40047739
132DYRK1A0.38627990
133GRK60.34937894
134PRKACA0.33084079
135CAMK2B0.31559703
136CLK10.31289378
137MAPK70.31143161
138MTOR0.25256038
139EPHA30.23152362
140AKT10.22640582

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.61224625
2Nicotine addiction_Homo sapiens_hsa050332.43186696
3Synaptic vesicle cycle_Homo sapiens_hsa047212.41213961
4Olfactory transduction_Homo sapiens_hsa047402.25956330
5Circadian entrainment_Homo sapiens_hsa047132.20853557
6Long-term potentiation_Homo sapiens_hsa047202.20360252
7Salivary secretion_Homo sapiens_hsa049702.13757754
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.13446705
9Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.13300438
10GABAergic synapse_Homo sapiens_hsa047272.08151968
11Glutamatergic synapse_Homo sapiens_hsa047241.95077028
12Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.94831941
13Morphine addiction_Homo sapiens_hsa050321.94537853
14Cardiac muscle contraction_Homo sapiens_hsa042601.92402009
15Dilated cardiomyopathy_Homo sapiens_hsa054141.92312219
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.86108336
17Gastric acid secretion_Homo sapiens_hsa049711.85348785
18Amphetamine addiction_Homo sapiens_hsa050311.70386011
19Oxytocin signaling pathway_Homo sapiens_hsa049211.67795860
20Insulin secretion_Homo sapiens_hsa049111.65394849
21Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.64845234
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62516221
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.61906110
24Calcium signaling pathway_Homo sapiens_hsa040201.61255946
25Alcoholism_Homo sapiens_hsa050341.58526294
26Systemic lupus erythematosus_Homo sapiens_hsa053221.52364543
27Dopaminergic synapse_Homo sapiens_hsa047281.51615339
28Type II diabetes mellitus_Homo sapiens_hsa049301.47969733
29Cholinergic synapse_Homo sapiens_hsa047251.47898607
30Vitamin B6 metabolism_Homo sapiens_hsa007501.43607572
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.38525458
32Renin secretion_Homo sapiens_hsa049241.34072800
33Malaria_Homo sapiens_hsa051441.30519226
34Gap junction_Homo sapiens_hsa045401.29220267
35Long-term depression_Homo sapiens_hsa047301.28297401
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27527375
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.27502989
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.27056585
39Carbon metabolism_Homo sapiens_hsa012001.26499343
40GnRH signaling pathway_Homo sapiens_hsa049121.24227764
41cAMP signaling pathway_Homo sapiens_hsa040241.24112884
42Regulation of autophagy_Homo sapiens_hsa041401.23902162
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22993319
44Glioma_Homo sapiens_hsa052141.19929212
45Nitrogen metabolism_Homo sapiens_hsa009101.18803082
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.18078610
47Taste transduction_Homo sapiens_hsa047421.17495467
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17380273
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16740771
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.16549120
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.14835246
52Collecting duct acid secretion_Homo sapiens_hsa049661.11901341
53Longevity regulating pathway - mammal_Homo sapiens_hsa042111.06459544
54Fructose and mannose metabolism_Homo sapiens_hsa000511.05972363
55Non-small cell lung cancer_Homo sapiens_hsa052231.05056291
56Pentose phosphate pathway_Homo sapiens_hsa000301.01568135
57Pancreatic secretion_Homo sapiens_hsa049721.00504820
58Cocaine addiction_Homo sapiens_hsa050301.00446746
59Dorso-ventral axis formation_Homo sapiens_hsa043200.98485016
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95359118
61Estrogen signaling pathway_Homo sapiens_hsa049150.94547950
62mTOR signaling pathway_Homo sapiens_hsa041500.94458012
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.93849923
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93625978
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91877239
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91801257
67Glucagon signaling pathway_Homo sapiens_hsa049220.90551867
68Insulin signaling pathway_Homo sapiens_hsa049100.89769675
69Arginine and proline metabolism_Homo sapiens_hsa003300.87473431
70Oocyte meiosis_Homo sapiens_hsa041140.84255097
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83352460
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.82870526
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.80168392
74Bile secretion_Homo sapiens_hsa049760.79727540
75ABC transporters_Homo sapiens_hsa020100.78706456
76AMPK signaling pathway_Homo sapiens_hsa041520.78487185
77Circadian rhythm_Homo sapiens_hsa047100.76589346
78Serotonergic synapse_Homo sapiens_hsa047260.75764462
79ErbB signaling pathway_Homo sapiens_hsa040120.74617639
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69533036
81Insulin resistance_Homo sapiens_hsa049310.66840714
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.65598643
83MAPK signaling pathway_Homo sapiens_hsa040100.64655694
84Pyruvate metabolism_Homo sapiens_hsa006200.64501375
85Choline metabolism in cancer_Homo sapiens_hsa052310.64216067
86Endocytosis_Homo sapiens_hsa041440.63518872
87Melanogenesis_Homo sapiens_hsa049160.62343133
88Inositol phosphate metabolism_Homo sapiens_hsa005620.61269997
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60608839
90VEGF signaling pathway_Homo sapiens_hsa043700.60553821
91Thyroid hormone synthesis_Homo sapiens_hsa049180.60014981
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59071803
93Chronic myeloid leukemia_Homo sapiens_hsa052200.58678925
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56900756
95Endometrial cancer_Homo sapiens_hsa052130.53740423
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.51963878
97Platelet activation_Homo sapiens_hsa046110.51528936
98Acute myeloid leukemia_Homo sapiens_hsa052210.51296238
99Renal cell carcinoma_Homo sapiens_hsa052110.50540367
100Pancreatic cancer_Homo sapiens_hsa052120.50020351
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47885628
102Biosynthesis of amino acids_Homo sapiens_hsa012300.47516249
103Focal adhesion_Homo sapiens_hsa045100.45846867
104FoxO signaling pathway_Homo sapiens_hsa040680.45072592
105Bladder cancer_Homo sapiens_hsa052190.44834903
106HIF-1 signaling pathway_Homo sapiens_hsa040660.42891944
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41718044
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.41691077
109Lysine degradation_Homo sapiens_hsa003100.38300979
110Starch and sucrose metabolism_Homo sapiens_hsa005000.37437542
111Prolactin signaling pathway_Homo sapiens_hsa049170.37075070
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32101824
113Arginine biosynthesis_Homo sapiens_hsa002200.30821599
114Rap1 signaling pathway_Homo sapiens_hsa040150.29767883
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29130983
116Tight junction_Homo sapiens_hsa045300.28951842

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