SPTBN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.65339364
2locomotory exploration behavior (GO:0035641)6.63749872
3regulation of short-term neuronal synaptic plasticity (GO:0048172)6.54717019
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.25041784
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.78228179
6vocalization behavior (GO:0071625)5.75267991
7synaptic vesicle docking involved in exocytosis (GO:0016081)5.52311096
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.51536062
9glutamate secretion (GO:0014047)5.43774213
10synaptic vesicle exocytosis (GO:0016079)5.32072972
11regulation of glutamate receptor signaling pathway (GO:1900449)5.18277694
12regulation of synaptic vesicle exocytosis (GO:2000300)5.06753486
13cytoskeletal anchoring at plasma membrane (GO:0007016)5.02998473
14exploration behavior (GO:0035640)4.92511633
15regulation of neuronal synaptic plasticity (GO:0048168)4.90631749
16regulation of long-term neuronal synaptic plasticity (GO:0048169)4.87594868
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.87253627
18regulation of synapse structural plasticity (GO:0051823)4.85522323
19layer formation in cerebral cortex (GO:0021819)4.73499675
20protein localization to synapse (GO:0035418)4.71300435
21dendritic spine morphogenesis (GO:0060997)4.66634595
22neurotransmitter secretion (GO:0007269)4.64230502
23neuronal action potential propagation (GO:0019227)4.54775544
24regulation of synaptic vesicle transport (GO:1902803)4.53381537
25neurotransmitter-gated ion channel clustering (GO:0072578)4.51573618
26synaptic transmission, glutamatergic (GO:0035249)4.48354558
27long-term memory (GO:0007616)4.30467267
28gamma-aminobutyric acid transport (GO:0015812)4.28717455
29glutamate receptor signaling pathway (GO:0007215)4.25278905
30positive regulation of membrane potential (GO:0045838)4.11839543
31regulation of dendritic spine morphogenesis (GO:0061001)4.06052388
32membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.05826699
33neuron-neuron synaptic transmission (GO:0007270)4.04580741
34regulation of excitatory postsynaptic membrane potential (GO:0060079)4.01943345
35positive regulation of synapse maturation (GO:0090129)4.00734909
36cellular potassium ion homeostasis (GO:0030007)3.97984965
37neuromuscular process controlling balance (GO:0050885)3.96878543
38proline transport (GO:0015824)3.92699297
39sodium ion export (GO:0071436)3.91318452
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.90720843
41neuron cell-cell adhesion (GO:0007158)3.86326697
42activation of protein kinase A activity (GO:0034199)3.80471571
43regulation of synaptic plasticity (GO:0048167)3.79882357
44regulation of postsynaptic membrane potential (GO:0060078)3.75863937
45amino acid import (GO:0043090)3.66345529
46auditory behavior (GO:0031223)3.62317667
47positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.59132168
48neurotransmitter transport (GO:0006836)3.59111755
49prepulse inhibition (GO:0060134)3.54938180
50cell migration in hindbrain (GO:0021535)3.53970259
51dendrite morphogenesis (GO:0048813)3.51728165
52negative regulation of dendrite morphogenesis (GO:0050774)3.51325106
53regulation of ARF protein signal transduction (GO:0032012)3.50458729
54dendritic spine organization (GO:0097061)3.46782050
55regulation of neurotransmitter secretion (GO:0046928)3.46166600
56transmission of nerve impulse (GO:0019226)3.45544858
57G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.42525506
58cerebellar Purkinje cell differentiation (GO:0021702)3.42263613
59regulation of neurotransmitter levels (GO:0001505)3.41550549
60potassium ion homeostasis (GO:0055075)3.40252825
61positive regulation of neurotransmitter secretion (GO:0001956)3.39216119
62cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.38743763
63regulation of synaptic transmission, glutamatergic (GO:0051966)3.35855022
64positive regulation of dendritic spine development (GO:0060999)3.34814107
65synaptic vesicle endocytosis (GO:0048488)3.34501839
66regulation of dendritic spine development (GO:0060998)3.32771665
67peptidyl-tyrosine autophosphorylation (GO:0038083)3.31947481
68long-term synaptic potentiation (GO:0060291)3.31710932
69response to auditory stimulus (GO:0010996)3.31029364
70glycine transport (GO:0015816)3.29851604
71regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.29347178
72cell communication by electrical coupling (GO:0010644)3.29077517
73cerebellar Purkinje cell layer development (GO:0021680)3.28757243
74positive regulation of neurotransmitter transport (GO:0051590)3.27517348
75positive regulation of dendritic spine morphogenesis (GO:0061003)3.24807902
76cell differentiation in hindbrain (GO:0021533)3.24362344
77neuron recognition (GO:0008038)3.22422437
78L-amino acid import (GO:0043092)3.22110054
79regulation of neurotransmitter transport (GO:0051588)3.20813695
80G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.19387981
81neuromuscular process controlling posture (GO:0050884)3.19021475
82membrane depolarization (GO:0051899)3.18993959
83cerebellar granule cell differentiation (GO:0021707)3.16923520
84positive regulation of synaptic transmission, GABAergic (GO:0032230)3.16484844
85regulation of vesicle fusion (GO:0031338)3.16323017
86neuronal ion channel clustering (GO:0045161)3.15714987
87positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.14527141
88apical protein localization (GO:0045176)3.12820839
89membrane depolarization during action potential (GO:0086010)3.11661057
90neuromuscular process (GO:0050905)3.09353352
91chemosensory behavior (GO:0007635)3.09344002
92axonal fasciculation (GO:0007413)3.07921215
93regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.06126638
94axon ensheathment in central nervous system (GO:0032291)3.06056148
95central nervous system myelination (GO:0022010)3.06056148
96learning (GO:0007612)3.05767370
97gamma-aminobutyric acid signaling pathway (GO:0007214)3.03636071
98membrane hyperpolarization (GO:0060081)3.03401859
99social behavior (GO:0035176)3.02889619
100intraspecies interaction between organisms (GO:0051703)3.02889619
101vesicle transport along microtubule (GO:0047496)3.01648896
102regulation of synaptic transmission (GO:0050804)3.01345596
103innervation (GO:0060384)3.00617606
104desmosome organization (GO:0002934)2.99735518
105behavioral defense response (GO:0002209)2.98413249
106behavioral fear response (GO:0001662)2.98413249
107positive regulation of synaptic transmission (GO:0050806)2.97987533
108postsynaptic membrane organization (GO:0001941)2.97469520
109cell communication involved in cardiac conduction (GO:0086065)2.96917991
110long term synaptic depression (GO:0060292)2.96551354
111regulation of synapse maturation (GO:0090128)2.95057006
112cellular sodium ion homeostasis (GO:0006883)2.91726790
113regulation of voltage-gated calcium channel activity (GO:1901385)2.91191636
114mating behavior (GO:0007617)2.85102915
115positive regulation of dendrite development (GO:1900006)2.82078308
116potassium ion import (GO:0010107)2.81901732
117cell-cell junction maintenance (GO:0045217)2.77015454
118establishment of mitochondrion localization (GO:0051654)2.76444543
119establishment of skin barrier (GO:0061436)2.69612544
120mitochondrion transport along microtubule (GO:0047497)2.68469926
121establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.68469926
122regulation of dendrite morphogenesis (GO:0048814)2.65511523
123neuromuscular synaptic transmission (GO:0007274)2.62070234
124visual learning (GO:0008542)2.54045358

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.77931091
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.03942734
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01794841
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00510826
5RARB_27405468_Chip-Seq_BRAIN_Mouse2.99808551
6DROSHA_22980978_ChIP-Seq_HELA_Human2.89956839
7REST_21632747_ChIP-Seq_MESCs_Mouse2.82553677
8GBX2_23144817_ChIP-Seq_PC3_Human2.81906460
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.77587234
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.77587234
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.65381232
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.63796571
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.57490119
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56908008
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.53034923
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.51188341
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42524721
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.42499475
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38790549
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.35220914
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.34356175
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.32644450
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.30659109
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.22271564
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.19703149
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.07721568
27* ESR2_21235772_ChIP-Seq_MCF-7_Human2.03227712
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.02782113
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01557832
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.94605652
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.89518421
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.87264294
33ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.82459832
34AR_21572438_ChIP-Seq_LNCaP_Human1.73936266
35* SMC4_20622854_ChIP-Seq_HELA_Human1.63191763
36* RACK7_27058665_Chip-Seq_MCF-7_Human1.57223388
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56992223
38CREB1_26743006_Chip-Seq_LNCaP_Human1.56217598
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53446289
40DNAJC2_21179169_ChIP-ChIP_NT2_Human1.52711680
41* KDM2B_26808549_Chip-Seq_K562_Human1.46010131
42RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.45683836
43P68_20966046_ChIP-Seq_HELA_Human1.38858278
44SMAD4_21799915_ChIP-Seq_A2780_Human1.37547894
45RING1B_27294783_Chip-Seq_ESCs_Mouse1.37503802
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36493402
47ZNF263_19887448_ChIP-Seq_K562_Human1.35839382
48KDM2B_26808549_Chip-Seq_DND41_Human1.35018084
49ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34947836
50CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.33945846
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33768859
52* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.32655222
53SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32039807
54WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31029810
55OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.30465626
56* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30201069
57WT1_25993318_ChIP-Seq_PODOCYTE_Human1.27834937
58AR_19668381_ChIP-Seq_PC3_Human1.25580795
59GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24037646
60* SOX2_21211035_ChIP-Seq_LN229_Gbm1.23441493
61UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23252604
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23191933
63ZNF274_21170338_ChIP-Seq_K562_Hela1.21050877
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18353835
65RING1B_27294783_Chip-Seq_NPCs_Mouse1.17025204
66KDM2B_26808549_Chip-Seq_JURKAT_Human1.16022858
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15982429
68TCF7_22412390_ChIP-Seq_EML_Mouse1.14850040
69SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14009183
70RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11934794
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11209117
72ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10732093
73* RUNX1_27514584_Chip-Seq_MCF-7_Human1.09292511
74ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09181473
75EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09095374
76ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08969987
77MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.08872142
78PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08432534
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08204979
80* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07929621
81STAT3_23295773_ChIP-Seq_U87_Human1.07478701
82TET1_21451524_ChIP-Seq_MESCs_Mouse1.06752469
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06203183
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04821735
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.04245422
86* AR_25329375_ChIP-Seq_VCAP_Human1.03537629
87P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03202412
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03038008
89TP53_20018659_ChIP-ChIP_R1E_Mouse1.02173413
90SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02129070
91GATA1_26923725_Chip-Seq_HPCs_Mouse1.01884703
92SA1_27219007_Chip-Seq_ERYTHROID_Human1.01064348
93SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00684561
94OCT4_19829295_ChIP-Seq_ESCs_Human1.00096902
95CTCF_27219007_Chip-Seq_Bcells_Human0.98744735
96TET1_21490601_ChIP-Seq_MESCs_Mouse0.97971775
97YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97469649
98* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97360920
99SMAD3_21741376_ChIP-Seq_HESCs_Human0.96944885
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96204393
101ARNT_22903824_ChIP-Seq_MCF-7_Human0.96189785
102SMAD4_21741376_ChIP-Seq_HESCs_Human0.95803438
103SMAD_19615063_ChIP-ChIP_OVARY_Human0.95093516
104AHR_22903824_ChIP-Seq_MCF-7_Human0.94323799
105ESR1_21235772_ChIP-Seq_MCF-7_Human0.94057092
106SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93362653
107* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93205713
108CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93082857
109* TP63_22573176_ChIP-Seq_HFKS_Human0.92776018
110TCF4_23295773_ChIP-Seq_U87_Human0.92736388
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92387745
112TAF15_26573619_Chip-Seq_HEK293_Human0.92292743
113SMAD3_21741376_ChIP-Seq_ESCs_Human0.91782035
114TP53_23651856_ChIP-Seq_MEFs_Mouse0.91315283
115RXR_22108803_ChIP-Seq_LS180_Human0.90788319
116RUNX1_26923725_Chip-Seq_HPCs_Mouse0.89966739
117P300_19829295_ChIP-Seq_ESCs_Human0.89866571
118CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89668693
119DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89322626
120TP53_16413492_ChIP-PET_HCT116_Human0.89095119
121CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88317057
122ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87585727
123SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87294583
124PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87020622
125ISL1_27105846_Chip-Seq_CPCs_Mouse0.86901967
126TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.86872025
127VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.86851482
128KLF4_19829295_ChIP-Seq_ESCs_Human0.85672998
129PKCTHETA_26484144_Chip-Seq_BREAST_Human0.84719392
130OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84659170
131TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84529220
132SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84417531
133NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83759817
134CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83749023
135PIAS1_25552417_ChIP-Seq_VCAP_Human0.81615010
136LXR_22292898_ChIP-Seq_THP-1_Human0.81322157
137AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80956227
138CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80650033
139ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.80292565
140CBX2_27304074_Chip-Seq_ESCs_Mouse0.79218578
141BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78613433
142SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78047695

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.80619804
2MP0003635_abnormal_synaptic_transmissio4.47653842
3MP0003880_abnormal_central_pattern4.28139551
4MP0004270_analgesia4.08804635
5MP0002063_abnormal_learning/memory/cond3.59078905
6MP0002822_catalepsy3.55194990
7MP0009745_abnormal_behavioral_response3.54511286
8MP0002064_seizures3.20544268
9MP0009046_muscle_twitch3.18026228
10MP0005423_abnormal_somatic_nervous2.87508631
11MP0001968_abnormal_touch/_nociception2.83311452
12MP0002572_abnormal_emotion/affect_behav2.82260919
13MP0002734_abnormal_mechanical_nocicepti2.68221036
14MP0001486_abnormal_startle_reflex2.61131543
15MP0002272_abnormal_nervous_system2.55744373
16MP0000566_synostosis2.29403062
17MP0009780_abnormal_chondrocyte_physiolo2.26592289
18MP0000537_abnormal_urethra_morphology2.24258833
19MP0001501_abnormal_sleep_pattern2.22292082
20MP0008569_lethality_at_weaning2.20119114
21MP0000579_abnormal_nail_morphology2.17661886
22MP0003329_amyloid_beta_deposits2.08802969
23MP0001440_abnormal_grooming_behavior2.06932453
24MP0002736_abnormal_nociception_after2.05324076
25MP0002735_abnormal_chemical_nociception2.05191153
26MP0004858_abnormal_nervous_system1.99801644
27MP0003705_abnormal_hypodermis_morpholog1.96837940
28MP0002733_abnormal_thermal_nociception1.93412345
29MP0004811_abnormal_neuron_physiology1.91851964
30MP0002909_abnormal_adrenal_gland1.88924397
31MP0001970_abnormal_pain_threshold1.86400185
32MP0002067_abnormal_sensory_capabilities1.81637002
33MP0002557_abnormal_social/conspecific_i1.74088248
34MP0002184_abnormal_innervation1.73956448
35MP0003123_paternal_imprinting1.73649328
36MP0002796_impaired_skin_barrier1.72288710
37MP0004885_abnormal_endolymph1.71981312
38MP0003879_abnormal_hair_cell1.71324307
39MP0000778_abnormal_nervous_system1.69295763
40MP0004924_abnormal_behavior1.69055787
41MP0005386_behavior/neurological_phenoty1.69055787
42MP0001348_abnormal_lacrimal_gland1.62619965
43MP0000955_abnormal_spinal_cord1.59567999
44MP0003633_abnormal_nervous_system1.49128250
45MP0002066_abnormal_motor_capabilities/c1.43686169
46MP0002249_abnormal_larynx_morphology1.43476084
47MP0005646_abnormal_pituitary_gland1.38980599
48MP0002882_abnormal_neuron_morphology1.37016017
49MP0003075_altered_response_to1.28137229
50MP0001346_abnormal_lacrimal_gland1.27569936
51MP0001984_abnormal_olfaction1.26292037
52MP0003631_nervous_system_phenotype1.26063876
53MP0000569_abnormal_digit_pigmentation1.19655436
54MP0008872_abnormal_physiological_respon1.13366362
55MP0003787_abnormal_imprinting1.12567659
56MP0002152_abnormal_brain_morphology1.11374308
57MP0001177_atelectasis1.10222032
58MP0010234_abnormal_vibrissa_follicle1.10138023
59MP0001502_abnormal_circadian_rhythm1.09593891
60MP0005076_abnormal_cell_differentiation1.09071733
61MP0003122_maternal_imprinting1.06955599
62MP0008961_abnormal_basal_metabolism1.06480606
63MP0003283_abnormal_digestive_organ1.06044236
64MP0003690_abnormal_glial_cell1.05993582
65MP0000604_amyloidosis1.04588672
66MP0008874_decreased_physiological_sensi1.04350161
67MP0004142_abnormal_muscle_tone1.02573159
68MP0002009_preneoplasia1.01191793
69MP0005623_abnormal_meninges_morphology1.00740830
70MP0002069_abnormal_eating/drinking_beha0.99965673
71MP0003632_abnormal_nervous_system0.96065278
72MP0005645_abnormal_hypothalamus_physiol0.94751970
73MP0002089_abnormal_postnatal_growth/wei0.91023520
74MP0006276_abnormal_autonomic_nervous0.90850908
75MP0005535_abnormal_body_temperature0.90758400
76MP0005167_abnormal_blood-brain_barrier0.90005774
77MP0005501_abnormal_skin_physiology0.89689995
78MP0004145_abnormal_muscle_electrophysio0.88015463
79MP0001905_abnormal_dopamine_level0.86050827
80MP0002229_neurodegeneration0.85988038
81MP0001849_ear_inflammation0.83203951
82MP0002234_abnormal_pharynx_morphology0.83032661
83MP0000678_abnormal_parathyroid_gland0.82320537
84MP0009672_abnormal_birth_weight0.81997040
85MP0000920_abnormal_myelination0.81393288
86MP0001529_abnormal_vocalization0.81298866
87MP0004185_abnormal_adipocyte_glucose0.79220034
88MP0000751_myopathy0.78218106
89MP0004085_abnormal_heartbeat0.77891452
90MP0002090_abnormal_vision0.77129742
91MP0003634_abnormal_glial_cell0.75285754
92MP0000534_abnormal_ureter_morphology0.74579044
93MP0004510_myositis0.73991834
94MP0000013_abnormal_adipose_tissue0.73128683
95MP0004742_abnormal_vestibular_system0.71369680
96MP0003315_abnormal_perineum_morphology0.69899209
97MP0001299_abnormal_eye_distance/0.69443441
98MP0005187_abnormal_penis_morphology0.67187796
99MP0002098_abnormal_vibrissa_morphology0.66417798
100MP0005670_abnormal_white_adipose0.66254959
101MP0010771_integument_phenotype0.65626765
102MP0005394_taste/olfaction_phenotype0.65048253
103MP0005499_abnormal_olfactory_system0.65048253
104MP0003137_abnormal_impulse_conducting0.63557761
105MP0001963_abnormal_hearing_physiology0.62379205
106MP0004043_abnormal_pH_regulation0.61817915
107MP0005377_hearing/vestibular/ear_phenot0.61414722
108MP0003878_abnormal_ear_physiology0.61414722
109MP0005551_abnormal_eye_electrophysiolog0.61336617
110MP0010678_abnormal_skin_adnexa0.60801953
111MP0004130_abnormal_muscle_cell0.60473264
112MP0002638_abnormal_pupillary_reflex0.58127333
113MP0003172_abnormal_lysosome_physiology0.58109267
114MP0001188_hyperpigmentation0.54865797
115MP0002752_abnormal_somatic_nervous0.54400463
116MP0010769_abnormal_survival0.54319690
117MP0005166_decreased_susceptibility_to0.54118350
118MP0010386_abnormal_urinary_bladder0.53932097
119MP0003861_abnormal_nervous_system0.53020748
120MP0000631_abnormal_neuroendocrine_gland0.51841386
121MP0004215_abnormal_myocardial_fiber0.51479619
122MP0003956_abnormal_body_size0.50857496
123MP0005409_darkened_coat_color0.50575142
124MP0010768_mortality/aging0.50461741
125MP0004233_abnormal_muscle_weight0.50037501
126MP0002082_postnatal_lethality0.49823614
127MP0010770_preweaning_lethality0.49823614
128MP0004484_altered_response_of0.49331844
129MP0001485_abnormal_pinna_reflex0.48957786
130MP0001664_abnormal_digestion0.48846270

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.34934774
2* Myokymia (HP:0002411)6.68897752
3Focal seizures (HP:0007359)5.76982473
4Visual hallucinations (HP:0002367)5.52035943
5Action tremor (HP:0002345)4.88830705
6Progressive cerebellar ataxia (HP:0002073)4.53847868
7Epileptic encephalopathy (HP:0200134)4.41958100
8Febrile seizures (HP:0002373)4.02052765
9Atonic seizures (HP:0010819)3.98072926
10Poor eye contact (HP:0000817)3.86428244
11Absence seizures (HP:0002121)3.81096393
12Ankle clonus (HP:0011448)3.80407728
13Impaired vibration sensation in the lower limbs (HP:0002166)3.78572743
14Abnormality of the lower motor neuron (HP:0002366)3.76919269
15Generalized tonic-clonic seizures (HP:0002069)3.76350239
16Broad-based gait (HP:0002136)3.70671410
17Supranuclear gaze palsy (HP:0000605)3.65660563
18Impaired social interactions (HP:0000735)3.52100658
19Abnormal social behavior (HP:0012433)3.52100658
20Depression (HP:0000716)3.48324764
21Papilledema (HP:0001085)3.46745403
22Dialeptic seizures (HP:0011146)3.45315427
23Urinary bladder sphincter dysfunction (HP:0002839)3.37998866
24Mutism (HP:0002300)3.24412541
25Postural instability (HP:0002172)3.23897650
26Torticollis (HP:0000473)3.18500277
27Anxiety (HP:0000739)3.12770553
28Genetic anticipation (HP:0003743)3.06931614
29Scanning speech (HP:0002168)3.04916028
30Annular pancreas (HP:0001734)3.04521385
31* Dysmetria (HP:0001310)3.03922636
32Hyperacusis (HP:0010780)3.01931496
33Focal dystonia (HP:0004373)3.00229326
34Truncal ataxia (HP:0002078)2.97841867
35Dysmetric saccades (HP:0000641)2.97748541
36Hemiplegia (HP:0002301)2.97643437
37Urinary urgency (HP:0000012)2.97311930
38Abnormal eating behavior (HP:0100738)2.90503561
39* Gaze-evoked nystagmus (HP:0000640)2.90204679
40Bronchomalacia (HP:0002780)2.85864953
41Spastic gait (HP:0002064)2.83003110
42Amblyopia (HP:0000646)2.81617119
43Ventricular fibrillation (HP:0001663)2.80711103
44Aplasia involving bones of the extremities (HP:0009825)2.77268189
45Aplasia involving bones of the upper limbs (HP:0009823)2.77268189
46Aplasia of the phalanges of the hand (HP:0009802)2.77268189
47* Dysdiadochokinesis (HP:0002075)2.76803037
48Hemiparesis (HP:0001269)2.75781179
49Stereotypic behavior (HP:0000733)2.73945579
50Megalencephaly (HP:0001355)2.73557818
51Hyperventilation (HP:0002883)2.66211947
52Craniofacial dystonia (HP:0012179)2.64391113
53Neurofibrillary tangles (HP:0002185)2.64055349
54Status epilepticus (HP:0002133)2.63876178
55Abnormality of binocular vision (HP:0011514)2.62954693
56Diplopia (HP:0000651)2.62954693
57Cerebral inclusion bodies (HP:0100314)2.58797092
58Bradykinesia (HP:0002067)2.57876964
59* Intention tremor (HP:0002080)2.54208941
60Drooling (HP:0002307)2.53569063
61Excessive salivation (HP:0003781)2.53569063
62Pointed chin (HP:0000307)2.52935005
63Bundle branch block (HP:0011710)2.46690075
64Epileptiform EEG discharges (HP:0011182)2.41842968
65Obstructive sleep apnea (HP:0002870)2.39121914
66* Impaired smooth pursuit (HP:0007772)2.38876631
67EEG with generalized epileptiform discharges (HP:0011198)2.36813477
68Abnormality of the corticospinal tract (HP:0002492)2.35838109
69Insomnia (HP:0100785)2.35831405
70Turricephaly (HP:0000262)2.35191552
71Amyotrophic lateral sclerosis (HP:0007354)2.33453287
72Hypsarrhythmia (HP:0002521)2.32244025
73Clonus (HP:0002169)2.28351068
74Shallow orbits (HP:0000586)2.27268986
75Termporal pattern (HP:0011008)2.24892441
76Insidious onset (HP:0003587)2.24892441
77Fetal akinesia sequence (HP:0001989)2.24333100
78Broad face (HP:0000283)2.23456427
79* Abnormality of ocular smooth pursuit (HP:0000617)2.21786267
80Lower limb muscle weakness (HP:0007340)2.21377267
81Tetraplegia (HP:0002445)2.21169224
82Progressive inability to walk (HP:0002505)2.18407322
83Lower limb asymmetry (HP:0100559)2.15890223
84Sleep apnea (HP:0010535)2.12918802
85Germ cell neoplasia (HP:0100728)2.12191955
86Generalized myoclonic seizures (HP:0002123)2.10838241
87Ankyloglossia (HP:0010296)2.10513247
88Akinesia (HP:0002304)2.10154755
89Resting tremor (HP:0002322)2.09018434
90* Impaired vibratory sensation (HP:0002495)2.04874899
91Abnormality of the salivary glands (HP:0010286)2.02423242
92Incomplete penetrance (HP:0003829)2.01860250
93Abnormality of the distal phalanx of the thumb (HP:0009617)1.99882457
94Bowel incontinence (HP:0002607)1.99792844
95Abnormality of the periventricular white matter (HP:0002518)1.98623270
96Lower limb amyotrophy (HP:0007210)1.98294803
97Neuronal loss in central nervous system (HP:0002529)1.98050809
98Agitation (HP:0000713)1.97101289
99Apathy (HP:0000741)1.96817870
100Absent speech (HP:0001344)1.95426175
101Spastic tetraparesis (HP:0001285)1.91893122
102Cerebral hypomyelination (HP:0006808)1.91721302
103Intellectual disability, profound (HP:0002187)1.91682011
104Rigidity (HP:0002063)1.90405271
105Inappropriate behavior (HP:0000719)1.90068907
106Abnormality of the aortic arch (HP:0012303)1.88707388
107Precocious puberty (HP:0000826)1.86667898
108Peripheral hypomyelination (HP:0007182)1.81775030
109Limb dystonia (HP:0002451)1.80404185
110Achilles tendon contracture (HP:0001771)1.79472580
111Abnormal EKG (HP:0003115)1.78959400
112Hammertoe (HP:0001765)1.78888488
113Hyperthyroidism (HP:0000836)1.78422153
114Pili torti (HP:0003777)1.78313341
115Advanced eruption of teeth (HP:0006288)1.77701854
116Overriding aorta (HP:0002623)1.77318510
117Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.77002117
118Distal upper limb amyotrophy (HP:0007149)1.76730792
119Upper limb amyotrophy (HP:0009129)1.76730792
120* Gait ataxia (HP:0002066)1.76727507
121Abnormal large intestine physiology (HP:0012700)1.76444935
122Renovascular hypertension (HP:0100817)1.74715401
123Abnormality of nail color (HP:0100643)1.74598149
124Morphological abnormality of the pyramidal tract (HP:0002062)1.73949098
125Partial duplication of thumb phalanx (HP:0009944)1.73757412
126Rapidly progressive (HP:0003678)1.73611019
127Inability to walk (HP:0002540)1.72192576
128Abnormality of the Achilles tendon (HP:0005109)1.72141152
129Delusions (HP:0000746)1.72078431
130Blue irides (HP:0000635)1.71564038
131Alacrima (HP:0000522)1.71073182
132Urethral obstruction (HP:0000796)1.70069082
133Macroorchidism (HP:0000053)1.68876107
134Tracheomalacia (HP:0002779)1.67839293
135Septate vagina (HP:0001153)1.66055504
136Elfin facies (HP:0004428)1.62904528
137Hand muscle atrophy (HP:0009130)1.62699804
138Neonatal death (HP:0003811)1.60954514
139Heterotopia (HP:0002282)1.60352865
140Distal sensory impairment (HP:0002936)1.59789513
141Thickened helices (HP:0000391)1.59627045

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.83750918
2MAP3K94.23568749
3NTRK34.15121115
4MARK13.42487000
5DAPK23.26031700
6CAMK1D3.24986371
7EEF2K2.92989871
8PRKD32.72389778
9MAP3K42.61431519
10PAK62.46779672
11CAMKK12.44823672
12KSR22.35305506
13NTRK22.16656467
14* MINK12.13721661
15ICK1.96615083
16MAP2K71.94923622
17NTRK11.93148021
18CDK121.84789240
19MAP2K41.76981019
20RIPK41.73853718
21DAPK11.72627574
22KSR11.66038265
23CDK51.62610159
24SMG11.61416201
25STK381.60979757
26TYRO31.45754660
27SIK21.44738903
28TAOK11.39458375
29PRPF4B1.39367414
30MAP3K21.38476427
31SIK11.32293401
32CAMKK21.31616348
33RIPK11.29593251
34PRKCG1.22880894
35TNIK1.18837954
36MAP3K131.14298779
37CDK191.10990387
38FES1.09807576
39GRK51.08611816
40ARAF1.07949650
41STK111.07419214
42CAMK11.07363112
43MAPK131.07171772
44EPHA21.04457358
45ALK1.03149343
46MTOR1.02911202
47MAP3K121.02625396
48LATS21.01025597
49PLK20.98449485
50UHMK10.97842470
51PHKG10.97744936
52PHKG20.97744936
53PRKCH0.97037598
54RET0.93103736
55BRAF0.91867390
56CDK150.91136182
57CDK180.89706179
58PINK10.89627245
59SGK2230.87483790
60SGK4940.87483790
61RAF10.85974416
62CDK140.81630127
63PDK10.81623893
64MARK20.80582897
65PNCK0.80148272
66CAMK2A0.79900315
67PKN20.79655734
68CDK11A0.79078290
69SGK30.78688706
70PRKD20.78539219
71TESK10.77246679
72MST1R0.74197099
73PDPK10.72856568
74SGK20.72305079
75SGK10.71013347
76LMTK20.69746777
77PTK2B0.67030747
78PAK30.66772312
79CAMK2B0.66090049
80MAP3K70.63933944
81DYRK1A0.62294091
82CAMK40.61534988
83AKT30.61329307
84IRAK20.61212543
85PRKCZ0.61057553
86CSNK1G20.61023794
87BRSK10.60945413
88SCYL20.59250168
89NEK10.57872992
90PRKCI0.57641422
91MAP3K10.56605365
92RPS6KA30.56016776
93PTK20.55824757
94BMPR20.55222775
95FYN0.52772508
96CAMK1G0.51566803
97ERBB20.51091521
98CASK0.50892323
99PRKAA10.49562294
100DAPK30.49524515
101CDC42BPA0.49221163
102OXSR10.49087434
103TRIB30.47606338
104MAPK80.46893369
105GSK3B0.45348271
106MAP3K110.44555103
107MAPK100.43909805
108DMPK0.42969571
109NEK60.41715982
110TNK20.41273903
111BRD40.40244108
112CAMK2G0.39368328
113MET0.39289352
114CSNK1E0.38821579
115MAP2K10.38172797
116FGFR20.38082292
117WNK10.37341247
118RPS6KB10.34840959
119PRKCB0.32010522
120MAP2K60.31697111
121RPS6KA20.31105090
122FER0.31024882
123PRKCE0.30222416
124MAPK120.30012674
125MAP3K60.29832340
126PDGFRA0.29412896

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.34390888
2Synaptic vesicle cycle_Homo sapiens_hsa047213.00366916
3Olfactory transduction_Homo sapiens_hsa047402.81414608
4Long-term potentiation_Homo sapiens_hsa047202.75203234
5Circadian entrainment_Homo sapiens_hsa047132.74697027
6Glutamatergic synapse_Homo sapiens_hsa047242.67725597
7GABAergic synapse_Homo sapiens_hsa047272.55734485
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.50696138
9Amphetamine addiction_Homo sapiens_hsa050312.41561415
10Morphine addiction_Homo sapiens_hsa050322.38666022
11Nitrogen metabolism_Homo sapiens_hsa009102.29212268
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.24609065
13Salivary secretion_Homo sapiens_hsa049702.20804707
14Dopaminergic synapse_Homo sapiens_hsa047282.08861755
15Aldosterone synthesis and secretion_Homo sapiens_hsa049252.02089399
16Insulin secretion_Homo sapiens_hsa049111.97667526
17Gastric acid secretion_Homo sapiens_hsa049711.97408761
18Cholinergic synapse_Homo sapiens_hsa047251.96992944
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.71036935
20Oxytocin signaling pathway_Homo sapiens_hsa049211.67763286
21Long-term depression_Homo sapiens_hsa047301.67574131
22Vitamin B6 metabolism_Homo sapiens_hsa007501.64216455
23Renin secretion_Homo sapiens_hsa049241.54778692
24Calcium signaling pathway_Homo sapiens_hsa040201.53743597
25Cocaine addiction_Homo sapiens_hsa050301.53550067
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.52989091
27GnRH signaling pathway_Homo sapiens_hsa049121.50143077
28Taste transduction_Homo sapiens_hsa047421.47159205
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.42673622
30Gap junction_Homo sapiens_hsa045401.35355161
31Type II diabetes mellitus_Homo sapiens_hsa049301.34435712
32Serotonergic synapse_Homo sapiens_hsa047261.32310848
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31979322
34cAMP signaling pathway_Homo sapiens_hsa040241.26738047
35Glioma_Homo sapiens_hsa052141.26507262
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24039752
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22316848
38Estrogen signaling pathway_Homo sapiens_hsa049151.21355596
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06465070
40ErbB signaling pathway_Homo sapiens_hsa040121.03866499
41Melanogenesis_Homo sapiens_hsa049161.02774587
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01840897
43Axon guidance_Homo sapiens_hsa043601.00138060
44Phospholipase D signaling pathway_Homo sapiens_hsa040720.93698927
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92835699
46Bile secretion_Homo sapiens_hsa049760.91659847
47Pancreatic secretion_Homo sapiens_hsa049720.89358552
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.88866285
49Thyroid hormone synthesis_Homo sapiens_hsa049180.86435596
50Oocyte meiosis_Homo sapiens_hsa041140.85669028
51Notch signaling pathway_Homo sapiens_hsa043300.84148539
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.82282179
53Dorso-ventral axis formation_Homo sapiens_hsa043200.80783055
54AMPK signaling pathway_Homo sapiens_hsa041520.80555280
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78622357
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77015420
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75355393
58Arginine biosynthesis_Homo sapiens_hsa002200.75264809
59Choline metabolism in cancer_Homo sapiens_hsa052310.74961854
60Tight junction_Homo sapiens_hsa045300.74495509
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.72566632
62VEGF signaling pathway_Homo sapiens_hsa043700.72171041
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70263798
64Collecting duct acid secretion_Homo sapiens_hsa049660.70134325
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68938181
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.68350103
67mTOR signaling pathway_Homo sapiens_hsa041500.67270662
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67247018
69Hippo signaling pathway_Homo sapiens_hsa043900.64711457
70Dilated cardiomyopathy_Homo sapiens_hsa054140.63013075
71MAPK signaling pathway_Homo sapiens_hsa040100.62940302
72Lysine degradation_Homo sapiens_hsa003100.62411658
73Glucagon signaling pathway_Homo sapiens_hsa049220.62207349
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60995531
75Biosynthesis of amino acids_Homo sapiens_hsa012300.60619403
76Arginine and proline metabolism_Homo sapiens_hsa003300.58165857
77Cardiac muscle contraction_Homo sapiens_hsa042600.57866748
78Rap1 signaling pathway_Homo sapiens_hsa040150.57862440
79Non-small cell lung cancer_Homo sapiens_hsa052230.57688650
80Endometrial cancer_Homo sapiens_hsa052130.55170883
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54630979
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54615599
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.52292492
84Adherens junction_Homo sapiens_hsa045200.52188444
85Endocytosis_Homo sapiens_hsa041440.52143630
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50686934
87Ras signaling pathway_Homo sapiens_hsa040140.49391599
88Inositol phosphate metabolism_Homo sapiens_hsa005620.49108070
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46888420
90Thyroid cancer_Homo sapiens_hsa052160.46152788
91Prion diseases_Homo sapiens_hsa050200.45592934
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44919467
93Insulin signaling pathway_Homo sapiens_hsa049100.43279724
94Fatty acid metabolism_Homo sapiens_hsa012120.41474763
95Alcoholism_Homo sapiens_hsa050340.40402594
96Chronic myeloid leukemia_Homo sapiens_hsa052200.39865087
97Phototransduction_Homo sapiens_hsa047440.38844247
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38370972
99Vibrio cholerae infection_Homo sapiens_hsa051100.37632460
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37630009
101Circadian rhythm_Homo sapiens_hsa047100.37476595
102Renal cell carcinoma_Homo sapiens_hsa052110.36196327
103MicroRNAs in cancer_Homo sapiens_hsa052060.35675274
104Phenylalanine metabolism_Homo sapiens_hsa003600.35591575
105Chemokine signaling pathway_Homo sapiens_hsa040620.34786019
106Butanoate metabolism_Homo sapiens_hsa006500.34219101
107Ovarian steroidogenesis_Homo sapiens_hsa049130.34085285
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33613714
109Basal cell carcinoma_Homo sapiens_hsa052170.33211694
110African trypanosomiasis_Homo sapiens_hsa051430.32829448
111Proteoglycans in cancer_Homo sapiens_hsa052050.32470844
112Hedgehog signaling pathway_Homo sapiens_hsa043400.32242653
113Wnt signaling pathway_Homo sapiens_hsa043100.31804612
114Type I diabetes mellitus_Homo sapiens_hsa049400.31785125
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.31640438
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29405990
117Fatty acid biosynthesis_Homo sapiens_hsa000610.28390385
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.27857368
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27775817
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27646096

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