SPTBN5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular visceral epithelial cell development (GO:0072015)6.37350157
2glomerular epithelial cell development (GO:0072310)5.54616057
3germinal center formation (GO:0002467)5.08570731
4glomerular basement membrane development (GO:0032836)4.22173838
5regulation of germinal center formation (GO:0002634)3.89733192
6semaphorin-plexin signaling pathway (GO:0071526)3.78716886
7mannose metabolic process (GO:0006013)3.69489137
8negative regulation of T-helper cell differentiation (GO:0045623)3.54488637
9negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.54488637
10plasma membrane repair (GO:0001778)3.47661580
11negative regulation of Rho protein signal transduction (GO:0035024)3.45255687
12mitochondrion distribution (GO:0048311)3.36916902
13endothelial cell chemotaxis (GO:0035767)3.34852031
14positive regulation of cellular amide metabolic process (GO:0034250)3.31624500
15cell morphogenesis involved in neuron differentiation (GO:0048667)3.28275082
16cell-substrate junction assembly (GO:0007044)3.21650320
17regulation of ARF GTPase activity (GO:0032312)3.20977169
18response to muramyl dipeptide (GO:0032495)3.18895903
19post-embryonic morphogenesis (GO:0009886)3.15203917
20positive regulation of p38MAPK cascade (GO:1900745)3.09402241
21regulation of platelet aggregation (GO:0090330)3.07848315
22cell adhesion mediated by integrin (GO:0033627)3.04475339
23negative regulation of erythrocyte differentiation (GO:0045647)3.04196892
24protein localization to endosome (GO:0036010)3.03205917
25regulation of memory T cell differentiation (GO:0043380)2.98281096
26positive regulation of receptor recycling (GO:0001921)2.98081482
27G-protein coupled receptor internalization (GO:0002031)2.98044099
28negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.95480999
29regulation of glycogen (starch) synthase activity (GO:2000465)2.94548815
30membrane depolarization during action potential (GO:0086010)2.94281178
31negative regulation of immunoglobulin mediated immune response (GO:0002890)2.93183371
32negative regulation of B cell mediated immunity (GO:0002713)2.93183371
33activation of Rac GTPase activity (GO:0032863)2.87832535
34epithelial cell differentiation involved in kidney development (GO:0035850)2.85358158
35cerebellar Purkinje cell differentiation (GO:0021702)2.83565075
36regulation of T-helper 2 cell differentiation (GO:0045628)2.82561469
37negative regulation of fatty acid transport (GO:2000192)2.82287962
38hemidesmosome assembly (GO:0031581)2.78175964
39positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.76618636
40negative regulation of homotypic cell-cell adhesion (GO:0034111)2.76471156
41positive regulation of protein kinase C signaling (GO:0090037)2.76134579
42regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.74300455
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.74279900
44carnitine shuttle (GO:0006853)2.73215002
45positive regulation by organism of defense response of other organism involved in symbiotic interact2.71013153
46modulation by symbiont of host immune response (GO:0052553)2.71013153
47positive regulation by symbiont of host defense response (GO:0052509)2.71013153
48modulation by symbiont of host defense response (GO:0052031)2.71013153
49modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.71013153
50modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.71013153
51phospholipid scrambling (GO:0017121)2.70324457
52desmosome organization (GO:0002934)2.70312655
53cytoskeletal anchoring at plasma membrane (GO:0007016)2.66057654
54cell volume homeostasis (GO:0006884)2.62808508
55regulation of dendritic cell antigen processing and presentation (GO:0002604)2.60065538
56I-kappaB phosphorylation (GO:0007252)2.58929649
57positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.57139723
58signal complex assembly (GO:0007172)2.56800432
59activation of MAPKKK activity (GO:0000185)2.56666029
60regulation of p38MAPK cascade (GO:1900744)2.56285834
61negative regulation of granulocyte differentiation (GO:0030853)2.56169928
62vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.53937211
63positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.51815236
64endothelium development (GO:0003158)2.51587758
65regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.49824443
66activation of JUN kinase activity (GO:0007257)2.48761209
67positive regulation of fibroblast migration (GO:0010763)2.48687651
68negative regulation of type 2 immune response (GO:0002829)2.48161143
69response to laminar fluid shear stress (GO:0034616)2.47185569
70modulation by symbiont of host cellular process (GO:0044068)2.47145427
71apoptotic process involved in morphogenesis (GO:0060561)2.46102393
72adherens junction assembly (GO:0034333)2.45856745
73lipopolysaccharide-mediated signaling pathway (GO:0031663)2.45645715
74positive regulation of Cdc42 GTPase activity (GO:0043089)2.45152297
75endocytic recycling (GO:0032456)2.44363964
76atrioventricular valve morphogenesis (GO:0003181)2.43416295
77neurofilament cytoskeleton organization (GO:0060052)2.42684467
78peptidyl-tyrosine autophosphorylation (GO:0038083)2.41604628
79regulation of type I interferon-mediated signaling pathway (GO:0060338)2.39961385
80NIK/NF-kappaB signaling (GO:0038061)2.38640809
81bundle of His cell to Purkinje myocyte communication (GO:0086069)2.37222353
82cardiac conduction (GO:0061337)2.37048722
83cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.36278942
84insulin-like growth factor receptor signaling pathway (GO:0048009)2.36194486
85cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.36112888
86positive regulation of histone deacetylation (GO:0031065)2.35996370
87vascular endothelial growth factor signaling pathway (GO:0038084)2.34338828
88acrosome reaction (GO:0007340)2.34193619
89intermediate filament organization (GO:0045109)2.34095437
90macrophage activation involved in immune response (GO:0002281)2.33581622
91response to type I interferon (GO:0034340)2.31588777
92positive regulation of cardiac muscle cell differentiation (GO:2000727)2.31188512
93regulation of membrane protein ectodomain proteolysis (GO:0051043)2.28850260
94regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.28319182
95positive regulation of Rac GTPase activity (GO:0032855)2.28197990
96adenosine receptor signaling pathway (GO:0001973)2.27915261
97regulation of alkaline phosphatase activity (GO:0010692)2.27373175
98negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.27369657
99regulation of vitamin D biosynthetic process (GO:0060556)2.27365462
100response to manganese ion (GO:0010042)2.27350178
101growth hormone receptor signaling pathway (GO:0060396)2.26333427
102epithelial cell differentiation involved in prostate gland development (GO:0060742)2.25999567
103regulation of interferon-beta biosynthetic process (GO:0045357)2.25727861
104positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.25282877
105response to peptidoglycan (GO:0032494)2.24353140
106negative regulation of interleukin-12 production (GO:0032695)2.24190299
107regulation of ARF protein signal transduction (GO:0032012)2.24126266
108carnitine transmembrane transport (GO:1902603)2.23821708
109basement membrane organization (GO:0071711)2.23248256
110positive regulation of cardiac muscle hypertrophy (GO:0010613)2.22803319
111positive regulation of muscle hypertrophy (GO:0014742)2.22803319
112type I interferon signaling pathway (GO:0060337)2.22638000
113cellular response to type I interferon (GO:0071357)2.22638000
114regulation of NFAT protein import into nucleus (GO:0051532)2.22051988
115regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.21394986
116negative regulation of cell killing (GO:0031342)2.21009538
117negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.21009538
118positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.20704866
119cell-substrate adherens junction assembly (GO:0007045)2.19901841
120focal adhesion assembly (GO:0048041)2.19901841
121response to fluid shear stress (GO:0034405)2.19749878
122establishment of skin barrier (GO:0061436)2.19068437
123negative regulation of alpha-beta T cell differentiation (GO:0046639)2.18652840
124regulation of water loss via skin (GO:0033561)2.18173965
125embryonic viscerocranium morphogenesis (GO:0048703)2.17055214
126fatty acid transmembrane transport (GO:1902001)2.16512512
127cAMP biosynthetic process (GO:0006171)2.16084552
128apoptotic cell clearance (GO:0043277)2.15630842
129thymic T cell selection (GO:0045061)2.15553237
130positive regulation of Rap GTPase activity (GO:0032854)2.14497312
131dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.13745404
132positive regulation of blood vessel endothelial cell migration (GO:0043536)2.13531381
133Rho protein signal transduction (GO:0007266)2.13380191
134protein kinase C signaling (GO:0070528)2.13012812
135positive regulation of protein dephosphorylation (GO:0035307)2.12725220
136angiogenesis involved in wound healing (GO:0060055)2.12105310
137cellular response to virus (GO:0098586)2.11853859
138axon extension involved in axon guidance (GO:0048846)2.11803399
139neuron projection extension involved in neuron projection guidance (GO:1902284)2.11803399
140neuronal action potential propagation (GO:0019227)2.11793592
141positive regulation of type 2 immune response (GO:0002830)2.10320782
142positive regulation of odontogenesis (GO:0042482)2.09310602
143negative regulation of Ras protein signal transduction (GO:0046580)2.08504922
144positive regulation of heat generation (GO:0031652)2.08170862
145detection of other organism (GO:0098543)2.07939821
146wound healing, spreading of epidermal cells (GO:0035313)2.07731741
147endodermal cell differentiation (GO:0035987)2.07275843
148positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.06621419
149coronary vasculature morphogenesis (GO:0060977)2.06570436
150negative regulation of myotube differentiation (GO:0010832)2.06255841
151cellular response to ethanol (GO:0071361)2.06203085
152cell communication involved in cardiac conduction (GO:0086065)2.06095674
153barbed-end actin filament capping (GO:0051016)2.05915743
154negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.05747654
155positive regulation of gamma-delta T cell activation (GO:0046645)2.05728458
156regulation of inositol phosphate biosynthetic process (GO:0010919)2.04938798
157positive regulation of cholesterol efflux (GO:0010875)2.04715509
158positive regulation of Rho GTPase activity (GO:0032321)2.04708868
159negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.04176328
160regulation of glutamate receptor signaling pathway (GO:1900449)2.04045793
161muscle atrophy (GO:0014889)2.03999698
162oxygen transport (GO:0015671)2.03797866
163regulation of Cdc42 GTPase activity (GO:0043088)2.03794194
164regulation of integrin activation (GO:0033623)2.03490962
165negative regulation of small GTPase mediated signal transduction (GO:0051058)2.02644848
166microglial cell activation (GO:0001774)2.02633060
167vesicle transport along microtubule (GO:0047496)2.02275010
168amino-acid betaine transport (GO:0015838)2.01979802
169carnitine transport (GO:0015879)2.01979802
170righting reflex (GO:0060013)2.01827203
171regulation of ruffle assembly (GO:1900027)2.01703663
172regulation of calcium ion transmembrane transport (GO:1903169)2.01678924
173regulation of calcium ion transmembrane transporter activity (GO:1901019)2.01678924
174nerve growth factor signaling pathway (GO:0038180)2.01669131
175substrate-dependent cell migration (GO:0006929)2.01274345
176synaptic vesicle docking involved in exocytosis (GO:0016081)2.01128385
177regulation of Rap GTPase activity (GO:0032317)2.00727040
178cell-cell junction maintenance (GO:0045217)2.00513108
179histone H3-K4 trimethylation (GO:0080182)2.00329376
180negative regulation of viral release from host cell (GO:1902187)1.99967235
181synaptic vesicle endocytosis (GO:0048488)1.99913498
182skeletal muscle adaptation (GO:0043501)1.99809506
183negative regulation of toll-like receptor signaling pathway (GO:0034122)1.98709614
184antigen processing and presentation of endogenous peptide antigen (GO:0002483)1.97568618

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.75117282
2LXR_22292898_ChIP-Seq_THP-1_Human2.61098799
3RARG_19884340_ChIP-ChIP_MEFs_Mouse2.45578973
4DROSHA_22980978_ChIP-Seq_HELA_Human2.42753857
5ELK3_25401928_ChIP-Seq_HUVEC_Human2.31739369
6GBX2_23144817_ChIP-Seq_PC3_Human2.20017207
7VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.12780780
8VDR_21846776_ChIP-Seq_THP-1_Human2.12566904
9KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.09766200
10TCF7_22412390_ChIP-Seq_EML_Mouse2.02224119
11RACK7_27058665_Chip-Seq_MCF-7_Human2.00077131
12EZH2_22144423_ChIP-Seq_EOC_Human1.88154663
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.87360780
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81325674
15STAT6_21828071_ChIP-Seq_BEAS2B_Human1.78915731
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78214187
17ESR1_21235772_ChIP-Seq_MCF-7_Human1.73237681
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72974608
19IRF8_22096565_ChIP-ChIP_GC-B_Human1.71443527
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62379367
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.61618650
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57733226
23AHR_22903824_ChIP-Seq_MCF-7_Human1.56934135
24MTF2_20144788_ChIP-Seq_MESCs_Mouse1.56802149
25SMC4_20622854_ChIP-Seq_HELA_Human1.56232142
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55344840
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.54838053
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.54704616
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.54301661
30TP53_16413492_ChIP-PET_HCT116_Human1.53975356
31* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.53473545
32SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.51582692
33UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.50398712
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50165127
35TP63_17297297_ChIP-ChIP_HaCaT_Human1.50024490
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49982199
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.49363614
38KDM2B_26808549_Chip-Seq_JURKAT_Human1.49035939
39CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.48878171
40P68_20966046_ChIP-Seq_HELA_Human1.48054586
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.47681858
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.47059572
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.46857711
44SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.44490282
45P63_26484246_Chip-Seq_KERATINOCYTES_Human1.44345594
46SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43984355
47VDR_24763502_ChIP-Seq_THP-1_Human1.43272258
48GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42533484
49EP300_21415370_ChIP-Seq_HL-1_Mouse1.42474477
50AR_21572438_ChIP-Seq_LNCaP_Human1.40123949
51MYC_22102868_ChIP-Seq_BL_Human1.39755908
52RNF2_18974828_ChIP-Seq_MESCs_Mouse1.37559283
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.37559283
54Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36205357
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35449486
56KDM2B_26808549_Chip-Seq_K562_Human1.35145673
57* RUNX1_27514584_Chip-Seq_MCF-7_Human1.34471266
58ARNT_22903824_ChIP-Seq_MCF-7_Human1.34299702
59* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34263549
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33374331
61JARID2_20064375_ChIP-Seq_MESCs_Mouse1.32726893
62ZFP281_27345836_Chip-Seq_ESCs_Mouse1.32022790
63VDR_24787735_ChIP-Seq_THP-1_Human1.31607641
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31383072
65ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.31271380
66CTCF_27219007_Chip-Seq_Bcells_Human1.31105559
67WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29966478
68TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29742070
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28862364
70CTNNB1_20460455_ChIP-Seq_HCT116_Human1.28690400
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28461097
72SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28421976
73DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28052343
74SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.27842653
75* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26823336
76ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26233915
77SA1_27219007_Chip-Seq_ERYTHROID_Human1.25454461
78* SMAD4_21799915_ChIP-Seq_A2780_Human1.24938676
79SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24909073
80EZH2_27294783_Chip-Seq_ESCs_Mouse1.24081551
81* TP63_22573176_ChIP-Seq_HFKS_Human1.24013434
82SUZ12_27294783_Chip-Seq_ESCs_Mouse1.23372341
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23309990
84IKZF1_21737484_ChIP-ChIP_HCT116_Human1.22906451
85RNF2_27304074_Chip-Seq_ESCs_Mouse1.22862614
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.22348157
87GATA1_19941827_ChIP-Seq_MEL_Mouse1.22014910
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21956831
89MAF_26560356_Chip-Seq_TH1_Human1.21668010
90RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.21068679
91P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20389087
92NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.18894555
93NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.18798455
94FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.18725654
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18714063
96ESR1_20079471_ChIP-ChIP_T-47D_Human1.17648220
97SPI1_23127762_ChIP-Seq_K562_Human1.17242828
98JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16759225
99NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16521832
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16460196
101SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.15814533
102BCOR_27268052_Chip-Seq_Bcells_Human1.15691691
103MAF_26560356_Chip-Seq_TH2_Human1.15152201
104CREB1_26743006_Chip-Seq_LNCaP_Human1.14088590
105SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13958344
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13821707
107MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.13777210
108STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13143388
109CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13001354
110TP53_22127205_ChIP-Seq_IMR90_Human1.12915225
111RARB_27405468_Chip-Seq_BRAIN_Mouse1.12570619
112STAT3_23295773_ChIP-Seq_U87_Human1.12364633
113BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12228298
114RXR_22108803_ChIP-Seq_LS180_Human1.10009917
115SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09573171
116SCL_19346495_ChIP-Seq_HPC-7_Human1.08302366
117SMAD3_21741376_ChIP-Seq_HESCs_Human1.07981224
118RUNX1_22412390_ChIP-Seq_EML_Mouse1.06612301
119EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06190117
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05799215
121* UBF1/2_26484160_Chip-Seq_HMECs_Human1.05745175
122UTX_26944678_Chip-Seq_JUKART_Human1.04240594
123BCL6_27268052_Chip-Seq_Bcells_Human1.03713372
124SMAD3_21741376_ChIP-Seq_EPCs_Human1.03158487
125GATA1_19941826_ChIP-Seq_K562_Human1.03136441
126TCF4_18268006_ChIP-ChIP_LS174T_Human1.02129271
127EZH2_27304074_Chip-Seq_ESCs_Mouse1.01736466
128TP53_23651856_ChIP-Seq_MEFs_Mouse1.01478409
129IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01212378
130SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01202086
131NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01066393
132EED_16625203_ChIP-ChIP_MESCs_Mouse1.01059216
133SMAD3_21741376_ChIP-Seq_ESCs_Human1.00918952
134SOX2_21211035_ChIP-Seq_LN229_Gbm1.00816677
135TET1_21451524_ChIP-Seq_MESCs_Mouse1.00572790
136TET1_21490601_ChIP-Seq_MESCs_Mouse0.98525196
137SMAD4_21741376_ChIP-Seq_HESCs_Human0.97965530
138SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97371825
139SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97371825
140TCF4_23295773_ChIP-Seq_U87_Human0.97302656
141SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96724478
142TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96671792
143MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96663276
144IRF8_27001747_Chip-Seq_BMDM_Mouse0.96504437
145ELF1_20517297_ChIP-Seq_JURKAT_Human0.96249981
146PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96130617
147TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95454901
148GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95294821
149AR_19668381_ChIP-Seq_PC3_Human0.94796235
150YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93824225
151GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93537777
152FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93319104
153IRF8_21731497_ChIP-ChIP_J774_Mouse0.92884694
154PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92818624
155PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91990393
156TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91579893
157BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91552364
158PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90977980
159REST_21632747_ChIP-Seq_MESCs_Mouse0.90830542
160PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90394148
161ATF3_27146783_Chip-Seq_COLON_Human0.90269789
162NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90233561
163NANOG_18555785_Chip-Seq_ESCs_Mouse0.89998655
164TBX20_22328084_ChIP-Seq_HEART_Mouse0.89799792
165TBX20_22080862_ChIP-Seq_HEART_Mouse0.89799792
166OCT4_19829295_ChIP-Seq_ESCs_Human0.89521952
167ERG_21242973_ChIP-ChIP_JURKAT_Human0.89104214
168TP53_18474530_ChIP-ChIP_U2OS_Human0.88666331
169KLF5_25053715_ChIP-Seq_YYC3_Human0.88507432
170WT1_19549856_ChIP-ChIP_CCG9911_Human0.87427290
171KDM2B_26808549_Chip-Seq_DND41_Human0.86643953
172SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85683051
173TBL1_22424771_ChIP-Seq_293T_Human0.84470415
174E2F1_18555785_Chip-Seq_ESCs_Mouse0.84141348
175TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.83105656

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.77962445
2MP0003705_abnormal_hypodermis_morpholog3.61784148
3MP0005623_abnormal_meninges_morphology3.53950738
4MP0001968_abnormal_touch/_nociception3.46316024
5MP0000751_myopathy3.40866408
6MP0002736_abnormal_nociception_after2.91958259
7MP0003045_fibrosis2.90461452
8MP0002735_abnormal_chemical_nociception2.88465365
9MP0004510_myositis2.88253367
10MP0000579_abnormal_nail_morphology2.67706574
11MP0004859_abnormal_synaptic_plasticity2.65386600
12MP0003453_abnormal_keratinocyte_physiol2.45610917
13MP0001849_ear_inflammation2.33436148
14MP0005409_darkened_coat_color2.25280389
15MP0000749_muscle_degeneration2.23351125
16MP0003436_decreased_susceptibility_to2.23150000
17MP0010368_abnormal_lymphatic_system2.19402239
18MP0005451_abnormal_body_composition2.17197651
19MP0004130_abnormal_muscle_cell2.13299895
20MP0003279_aneurysm2.11592806
21MP0003303_peritoneal_inflammation2.06367917
22MP0009046_muscle_twitch2.04764952
23MP0000747_muscle_weakness2.04120822
24MP0004381_abnormal_hair_follicle2.02079870
25MP0009840_abnormal_foam_cell1.98907499
26MP0003724_increased_susceptibility_to1.98223818
27MP0003183_abnormal_peptide_metabolism1.90714821
28MP0005670_abnormal_white_adipose1.90509850
29MP0004270_analgesia1.87551188
30MP0003091_abnormal_cell_migration1.85619587
31MP0004858_abnormal_nervous_system1.84988446
32MP0002933_joint_inflammation1.82316301
33MP0002796_impaired_skin_barrier1.80338789
34MP0003787_abnormal_imprinting1.80325880
35MP0006082_CNS_inflammation1.73144727
36MP0008004_abnormal_stomach_pH1.68041938
37MP0003566_abnormal_cell_adhesion1.68016362
38MP0005167_abnormal_blood-brain_barrier1.67139833
39MP0003191_abnormal_cellular_cholesterol1.66677099
40MP0004145_abnormal_muscle_electrophysio1.65195469
41MP0008961_abnormal_basal_metabolism1.64345451
42MP0002733_abnormal_thermal_nociception1.64002459
43MP0009278_abnormal_bone_marrow1.61473838
44MP0002234_abnormal_pharynx_morphology1.60010394
45MP0002067_abnormal_sensory_capabilities1.58776499
46MP0002734_abnormal_mechanical_nocicepti1.54946098
47MP0003172_abnormal_lysosome_physiology1.54329894
48MP0003300_gastrointestinal_ulcer1.53431631
49MP0003635_abnormal_synaptic_transmissio1.51665193
50MP0000383_abnormal_hair_follicle1.50433402
51MP0005023_abnormal_wound_healing1.48006722
52MP0001348_abnormal_lacrimal_gland1.46900507
53MP0004185_abnormal_adipocyte_glucose1.46016956
54MP0010678_abnormal_skin_adnexa1.34683231
55MP0005275_abnormal_skin_tensile1.34544844
56MP0005000_abnormal_immune_tolerance1.34530950
57MP0002419_abnormal_innate_immunity1.32566541
58MP0005025_abnormal_response_to1.30936649
59MP0004084_abnormal_cardiac_muscle1.30299843
60MP0002998_abnormal_bone_remodeling1.30252949
61MP0001790_abnormal_immune_system1.28732996
62MP0005387_immune_system_phenotype1.28732996
63MP0002060_abnormal_skin_morphology1.28200273
64MP0008260_abnormal_autophagy1.27390700
65MP0002168_other_aberrant_phenotype1.26964745
66MP0000759_abnormal_skeletal_muscle1.26638912
67MP0002148_abnormal_hypersensitivity_rea1.25619949
68MP0001970_abnormal_pain_threshold1.25600650
69MP0003828_pulmonary_edema1.25220333
70MP0004087_abnormal_muscle_fiber1.24071794
71MP0010155_abnormal_intestine_physiology1.22726382
72MP0001533_abnormal_skeleton_physiology1.21605202
73MP0002106_abnormal_muscle_physiology1.20795466
74MP0006138_congestive_heart_failure1.19403308
75MP0003075_altered_response_to1.18712969
76MP0005410_abnormal_fertilization1.18422516
77MP0002064_seizures1.17488624
78MP0000465_gastrointestinal_hemorrhage1.16430777
79MP0002089_abnormal_postnatal_growth/wei1.15759339
80MP0004036_abnormal_muscle_relaxation1.15524359
81MP0002269_muscular_atrophy1.15186205
82MP0001486_abnormal_startle_reflex1.14331163
83MP0001216_abnormal_epidermal_layer1.12893026
84MP0000858_altered_metastatic_potential1.11612236
85MP0001853_heart_inflammation1.09625612
86MP0003763_abnormal_thymus_physiology1.09597397
87MP0009745_abnormal_behavioral_response1.08741790
88MP0009785_altered_susceptibility_to1.08350602
89MP0005310_abnormal_salivary_gland1.07333859
90MP0005058_abnormal_lysosome_morphology1.06206179
91MP0000750_abnormal_muscle_regeneration1.06116362
92MP0002452_abnormal_antigen_presenting1.04841385
93MP0001440_abnormal_grooming_behavior1.04353918
94MP0005595_abnormal_vascular_smooth1.04158028
95MP0005166_decreased_susceptibility_to1.03115626
96MP0002138_abnormal_hepatobiliary_system1.02873989
97MP0001800_abnormal_humoral_immune1.01764835
98MP0005666_abnormal_adipose_tissue1.00583300
99MP0001958_emphysema1.00209281
100MP0002723_abnormal_immune_serum1.00136791
101MP0002063_abnormal_learning/memory/cond0.99788322
102MP0005369_muscle_phenotype0.99021973
103MP0003646_muscle_fatigue0.98999217
104MP0002332_abnormal_exercise_endurance0.98960529
105MP0001661_extended_life_span0.97515728
106MP0004484_altered_response_of0.97288307
107MP0003879_abnormal_hair_cell0.97239734
108MP0008438_abnormal_cutaneous_collagen0.96727133
109MP0001835_abnormal_antigen_presentation0.95755060
110MP0003633_abnormal_nervous_system0.94928372
111MP0010234_abnormal_vibrissa_follicle0.94728536
112MP0008569_lethality_at_weaning0.93612145
113MP0004947_skin_inflammation0.93238878
114MP0001501_abnormal_sleep_pattern0.90676851
115MP0005375_adipose_tissue_phenotype0.90277910
116MP0003329_amyloid_beta_deposits0.89897115
117MP0000249_abnormal_blood_vessel0.87794797
118MP0000604_amyloidosis0.87699111
119MP0002572_abnormal_emotion/affect_behav0.87176228
120MP0005076_abnormal_cell_differentiation0.86738789
121MP0000013_abnormal_adipose_tissue0.85928788
122MP0005671_abnormal_response_to0.85530867
123MP0005330_cardiomyopathy0.85174038
124MP0001819_abnormal_immune_cell0.84748573
125MP0005501_abnormal_skin_physiology0.84052968
126MP0001873_stomach_inflammation0.82954410
127MP0000920_abnormal_myelination0.82827293
128MP0003634_abnormal_glial_cell0.82820098
129MP0002420_abnormal_adaptive_immunity0.82523490
130MP0002108_abnormal_muscle_morphology0.82335213
131MP0002098_abnormal_vibrissa_morphology0.80828733
132MP0009931_abnormal_skin_appearance0.80306891
133MP0004142_abnormal_muscle_tone0.80272444
134MP0004272_abnormal_basement_membrane0.80206609
135MP0000462_abnormal_digestive_system0.79705869
136MP0001879_abnormal_lymphatic_vessel0.79620353
137MP0010630_abnormal_cardiac_muscle0.79487249
138MP0000685_abnormal_immune_system0.79314782
139MP0000678_abnormal_parathyroid_gland0.79175644
140MP0002896_abnormal_bone_mineralization0.78969332
141MP0000955_abnormal_spinal_cord0.78890946
142MP0002272_abnormal_nervous_system0.78799476
143MP0004811_abnormal_neuron_physiology0.78718687
144MP0003448_altered_tumor_morphology0.77948135
145MP0000733_abnormal_muscle_development0.76524219
146MP0001727_abnormal_embryo_implantation0.76410462
147MP0005620_abnormal_muscle_contractility0.75673812
148MP0000427_abnormal_hair_cycle0.75405663
149MP0002405_respiratory_system_inflammati0.74197637
150MP0010307_abnormal_tumor_latency0.74170568
151MP0002972_abnormal_cardiac_muscle0.72880777
152MP0000343_altered_response_to0.72516224
153MP0010771_integument_phenotype0.72476136
154MP0008775_abnormal_heart_ventricle0.72236207
155MP0002254_reproductive_system_inflammat0.71796890
156MP0005257_abnormal_intraocular_pressure0.71030060
157MP0003690_abnormal_glial_cell0.70811135
158MP0001851_eye_inflammation0.70707727
159MP0008874_decreased_physiological_sensi0.69579684
160MP0004215_abnormal_myocardial_fiber0.68763146
161MP0002837_dystrophic_cardiac_calcinosis0.65187177
162MP0000003_abnormal_adipose_tissue0.64580137
163MP0000767_abnormal_smooth_muscle0.62739050

Predicted human phenotypes

RankGene SetZ-score
1Upper limb muscle weakness (HP:0003484)5.79011371
2Ulnar claw (HP:0001178)5.62230877
3Obstructive sleep apnea (HP:0002870)4.46706101
4Lower limb amyotrophy (HP:0007210)4.28705334
5Segmental peripheral demyelination/remyelination (HP:0003481)4.17256471
6Distal lower limb amyotrophy (HP:0008944)3.94131886
7Cervical subluxation (HP:0003308)3.85315572
8Onion bulb formation (HP:0003383)3.54692130
9Termporal pattern (HP:0011008)3.54286216
10Insidious onset (HP:0003587)3.54286216
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.46379258
12Thin bony cortex (HP:0002753)3.39526222
13Increased CSF protein (HP:0002922)3.38435249
14Broad face (HP:0000283)3.33431483
15Hyporeflexia of lower limbs (HP:0002600)3.27350885
16Decreased number of peripheral myelinated nerve fibers (HP:0003380)3.22873052
17Difficulty running (HP:0009046)3.21705018
18Abnormality of the parathyroid morphology (HP:0011766)3.21036603
19Decreased motor nerve conduction velocity (HP:0003431)3.01868112
20Febrile seizures (HP:0002373)3.01861444
21Muscle fiber splitting (HP:0003555)2.96493943
22Dysostosis multiplex (HP:0000943)2.90499727
23Difficulty climbing stairs (HP:0003551)2.89371360
24Neurofibrillary tangles (HP:0002185)2.85896524
25Impaired proprioception (HP:0010831)2.83625717
26Distal lower limb muscle weakness (HP:0009053)2.82090037
27Chromsome breakage (HP:0040012)2.80173376
28Foot dorsiflexor weakness (HP:0009027)2.75807603
29Peripheral demyelination (HP:0011096)2.73487556
30Flat acetabular roof (HP:0003180)2.71806743
31Ankle clonus (HP:0011448)2.69137314
32Hammertoe (HP:0001765)2.64565094
33Action tremor (HP:0002345)2.63935965
34Steppage gait (HP:0003376)2.61847067
35Abnormality of nail color (HP:0100643)2.59127778
36Abnormality of mucopolysaccharide metabolism (HP:0011020)2.53437094
37Abnormality of polysaccharide metabolism (HP:0011012)2.53437094
38Abnormality of glycosaminoglycan metabolism (HP:0004371)2.53437094
39Mucopolysacchariduria (HP:0008155)2.51480811
40Urinary glycosaminoglycan excretion (HP:0003541)2.51480811
41Malnutrition (HP:0004395)2.46738673
42Increased connective tissue (HP:0009025)2.45861028
43Bundle branch block (HP:0011710)2.45705339
44Abnormality of the foot musculature (HP:0001436)2.44645462
45Urethral obstruction (HP:0000796)2.44241635
46Joint stiffness (HP:0001387)2.36787951
47Nuclear cataract (HP:0100018)2.34959738
48Fragile skin (HP:0001030)2.31549390
49Cerebral aneurysm (HP:0004944)2.29936691
50Focal segmental glomerulosclerosis (HP:0000097)2.29292958
51Mesangial abnormality (HP:0001966)2.28466134
52Plantar hyperkeratosis (HP:0007556)2.23959206
53Cerebral inclusion bodies (HP:0100314)2.22128712
54Mediastinal lymphadenopathy (HP:0100721)2.21562520
55Rapidly progressive (HP:0003678)2.20977005
56Exercise-induced myalgia (HP:0003738)2.19654958
57Focal seizures (HP:0007359)2.18954612
58Abnormality of liposaccharide metabolism (HP:0010968)2.13818049
59Abnormality of glycosphingolipid metabolism (HP:0004343)2.13818049
60Abnormality of glycolipid metabolism (HP:0010969)2.13818049
61Myotonia (HP:0002486)2.12955567
62Prostate neoplasm (HP:0100787)2.12911705
63Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.12598949
64Colitis (HP:0002583)2.12568538
65Distal sensory impairment (HP:0002936)2.12530307
66Eczematoid dermatitis (HP:0000976)2.11542902
67Increased cerebral lipofuscin (HP:0011813)2.11094112
68Asymmetric septal hypertrophy (HP:0001670)2.10695209
69Exotropia (HP:0000577)2.10033494
70Disproportionate tall stature (HP:0001519)2.09391111
71Annular pancreas (HP:0001734)2.08406638
72Urinary urgency (HP:0000012)2.07993810
73Shallow orbits (HP:0000586)2.07352478
74Atrophic scars (HP:0001075)2.05613627
75Right ventricular cardiomyopathy (HP:0011663)2.05531824
76Progressive sensorineural hearing impairment (HP:0000408)2.05095168
77Urinary bladder sphincter dysfunction (HP:0002839)2.04355711
78Onycholysis (HP:0001806)2.03301423
79Hemorrhage of the eye (HP:0011885)2.03100801
80Stage 5 chronic kidney disease (HP:0003774)2.00794779
81Pustule (HP:0200039)1.99913209
82Epiphyseal dysplasia (HP:0002656)1.99532906
83Nephritis (HP:0000123)1.98434614
84Neonatal respiratory distress (HP:0002643)1.97179675
85Frequent falls (HP:0002359)1.97019050
86Abnormality of the fingertips (HP:0001211)1.96733463
87Delayed epiphyseal ossification (HP:0002663)1.96417036
88Abnormal vertebral ossification (HP:0100569)1.96140724
89Focal motor seizures (HP:0011153)1.95863060
90Submucous cleft hard palate (HP:0000176)1.94623376
91Alopecia of scalp (HP:0002293)1.94521443
92Fragile nails (HP:0001808)1.94384605
93Nail dystrophy (HP:0008404)1.94321755
94J-shaped sella turcica (HP:0002680)1.93425493
95Aneurysm (HP:0002617)1.91451618
96Hypoplastic ischia (HP:0003175)1.91168410
97Spontaneous hematomas (HP:0007420)1.90921202
98Thoracic kyphosis (HP:0002942)1.90107987
99Enlarged epiphyses (HP:0010580)1.89904281
100Protuberant abdomen (HP:0001538)1.87908168
101Stridor (HP:0010307)1.87100455
102Limited hip movement (HP:0008800)1.85434755
103Progressive hearing impairment (HP:0001730)1.83086953
104Mask-like facies (HP:0000298)1.82964403
105Metaphyseal cupping (HP:0003021)1.82910827
106Impaired vibration sensation in the lower limbs (HP:0002166)1.82306604
107Thin ribs (HP:0000883)1.81729697
108Tetany (HP:0001281)1.81267758
109Sudden death (HP:0001699)1.80810241
110Abnormality of macrophages (HP:0004311)1.80808227
111Pili torti (HP:0003777)1.80280004
112Mildly elevated creatine phosphokinase (HP:0008180)1.79786939
113Loss of speech (HP:0002371)1.79475647
114Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.79087938
115Abnormality of vision evoked potentials (HP:0000649)1.78604276
116Vertebral clefting (HP:0008428)1.78316147
117Supranuclear gaze palsy (HP:0000605)1.78241868
118Neuronal loss in central nervous system (HP:0002529)1.77407801
119Glomerulonephritis (HP:0000099)1.77302398
120Stomatitis (HP:0010280)1.76101426
121Increased IgE level (HP:0003212)1.75471299
122Hyperacusis (HP:0010780)1.75356474
123Mitral valve prolapse (HP:0001634)1.75119768
124Abnormality of the thoracic spine (HP:0100711)1.75073740
125Vitreoretinal degeneration (HP:0000655)1.75004416
126Abnormal blistering of the skin (HP:0008066)1.74928115
127Abnormality of the peritoneum (HP:0002585)1.74614803
128Interstitial pulmonary disease (HP:0006530)1.73986502
129Increased neuronal autofluorescent lipopigment (HP:0002074)1.73983219
130Hand muscle atrophy (HP:0009130)1.73825781
131Systemic lupus erythematosus (HP:0002725)1.73682135
132Lower limb muscle weakness (HP:0007340)1.73393016
133Ulnar bowing (HP:0003031)1.73037946
134Premature rupture of membranes (HP:0001788)1.72640138
135Lip pit (HP:0100267)1.72417380
136Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.71672767
137Progressive cerebellar ataxia (HP:0002073)1.70204086
138Increased variability in muscle fiber diameter (HP:0003557)1.70040175
139Milia (HP:0001056)1.69533800
140Hemiplegia (HP:0002301)1.69417614
141Hypoplasia of dental enamel (HP:0006297)1.69234998
142Abnormality of the neuromuscular junction (HP:0003398)1.68693718
143Fatigable weakness (HP:0003473)1.68693718
144Distal arthrogryposis (HP:0005684)1.68605882
145Resting tremor (HP:0002322)1.68311627
146Abnormality of the ischium (HP:0003174)1.68074370
147Polygenic inheritance (HP:0010982)1.64969800
148Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.64712685
149Flat capital femoral epiphysis (HP:0003370)1.64620906
150Hematochezia (HP:0002573)1.64139041
151Dislocated radial head (HP:0003083)1.63595470
152Lymphangioma (HP:0100764)1.63411801
153Protrusio acetabuli (HP:0003179)1.63137491
154Global brain atrophy (HP:0002283)1.62773502
155Long toe (HP:0010511)1.62114140
156Postural tremor (HP:0002174)1.62073320
157Upper limb amyotrophy (HP:0009129)1.61614324
158Distal upper limb amyotrophy (HP:0007149)1.61614324
159Axonal loss (HP:0003447)1.61477173
160Flattened epiphyses (HP:0003071)1.61330355
161Abnormality of the radial head (HP:0003995)1.60949930
162Chin dimple (HP:0010751)1.60861610
163Syncope (HP:0001279)1.60660623
164Nephroblastoma (Wilms tumor) (HP:0002667)1.60480633
165Elfin facies (HP:0004428)1.59931238
166Autoimmune thrombocytopenia (HP:0001973)1.59239069
167Esophageal varix (HP:0002040)1.59114088
168Gingivitis (HP:0000230)1.58925239
169Hypoplasia of the odontoid process (HP:0003311)1.58752144
170EMG: neuropathic changes (HP:0003445)1.58398355
171Orchitis (HP:0100796)1.58130946
172Postural instability (HP:0002172)1.58079367
173Thick nail (HP:0001805)1.57830165
174Glomerulosclerosis (HP:0000096)1.56007089
175Embryonal renal neoplasm (HP:0011794)1.55933603
176Persistence of primary teeth (HP:0006335)1.55848190
177Slow saccadic eye movements (HP:0000514)1.54332359
178Bradycardia (HP:0001662)1.53726729
179Atonic seizures (HP:0010819)1.53696296
180Abnormality of calcium-phosphate metabolism (HP:0100530)1.53658157
181Abnormality of the calf musculature (HP:0001430)1.52338495

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.87475763
2NTRK33.08358605
3GRK12.81780851
4MAP3K132.75583859
5CAMK1D2.63276805
6SIK12.60306044
7RIPK42.55094431
8CAMK1G2.53978782
9CASK2.48968791
10TIE12.38845522
11DDR22.22035052
12PRPF4B2.15663703
13MST1R2.09496996
14ERN12.07348466
15MAPK151.99693448
16TTN1.96202817
17LMTK21.84935183
18MAP3K141.77151548
19EPHA21.75419287
20TNK21.74950553
21MAP4K11.68387545
22TRIB31.63993267
23PTK2B1.61581157
24DAPK21.57186888
25JAK11.55529266
26SIK21.52767583
27OBSCN1.51904164
28MAP3K41.48764184
29PHKG21.46841321
30PHKG11.46841321
31RET1.44322014
32CDK121.41900358
33TAOK31.40739803
34ZAP701.37523834
35TBK11.30903509
36WNK11.30155720
37EPHB11.29850443
38SIK31.29138651
39PAK61.27055394
40CSK1.25674816
41PKN21.25107778
42PRKD21.22771705
43ARAF1.21965270
44ICK1.20219097
45FGFR41.20184712
46FGR1.18084503
47CDK191.17812894
48TGFBR21.17243566
49MAP2K31.14553171
50SMG11.14351231
51INSRR1.13784886
52RIPK11.11046751
53MAP3K71.09479093
54CDC42BPA1.09234407
55FER1.08400794
56DMPK1.05375222
57KSR21.04681769
58MAP3K31.04212422
59PDK11.02029001
60MAP3K111.00363571
61PTK60.99853031
62IRAK30.99766932
63FES0.99707924
64KDR0.99049489
65PDGFRA0.98077267
66NME20.97361416
67TYK20.97066018
68MET0.95840581
69PDPK10.93146591
70EPHA30.92712638
71PTK20.86897539
72JAK30.85899334
73TAOK10.85006120
74MAP2K40.82502227
75IKBKE0.82172141
76SGK10.82079755
77MAP3K20.81541612
78EEF2K0.80914545
79TYRO30.80604316
80ERBB20.79642734
81PLK20.79631460
82MAP2K60.77966042
83CHUK0.75724168
84PRKD30.74964740
85MAPK70.74815383
86CDK50.73868312
87SGK20.73716814
88MAPK120.73588104
89PDK30.72907633
90PDK40.72907633
91RPS6KL10.72757506
92RPS6KC10.72757506
93HIPK20.71638508
94NTRK10.70792984
95SGK30.68147675
96MINK10.66997942
97TRPM70.66574191
98WNK40.66506944
99BMX0.66285967
100CSF1R0.66285156
101TAOK20.66204475
102MAPK100.65821981
103OXSR10.65131906
104CAMKK20.63398319
105MARK20.61781392
106PKN10.61132886
107HCK0.60886150
108MAP3K60.60846682
109RPS6KA60.60803209
110IKBKB0.59836177
111ITK0.59406884
112PAK20.59266787
113STK110.58885899
114SGK2230.58885723
115SGK4940.58885723
116MOS0.58404882
117PAK40.58092958
118PIK3CA0.58043708
119MAP3K10.57512363
120JAK20.56102682
121PRKCH0.55694939
122BTK0.55552296
123MAP2K70.55395710
124CAMKK10.54955176
125EPHB20.54921365
126PDK20.54227789
127ROCK10.53754133
128RPS6KA20.53706233
129PRKAA20.53034265
130STK380.52367576
131PRKCE0.51833039
132PDGFRB0.51021327
133MTOR0.50172700
134BRD40.49269642
135MATK0.48810493
136PIM20.47377837
137FYN0.46827393
138LCK0.46777705
139PIK3CG0.46306922
140INSR0.45796294
141DAPK10.44925275
142LATS20.44482057
143BLK0.42836831
144PRKD10.42143032
145MUSK0.41875396
146KIT0.40472028

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.46034175
2Glycosaminoglycan degradation_Homo sapiens_hsa005312.10822021
3Synaptic vesicle cycle_Homo sapiens_hsa047211.84636548
4Notch signaling pathway_Homo sapiens_hsa043301.79800273
5Type II diabetes mellitus_Homo sapiens_hsa049301.79340732
6Dorso-ventral axis formation_Homo sapiens_hsa043201.73590447
7Phosphatidylinositol signaling system_Homo sapiens_hsa040701.53125017
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.50557968
9Collecting duct acid secretion_Homo sapiens_hsa049661.49344554
10TNF signaling pathway_Homo sapiens_hsa046681.48177549
11Dilated cardiomyopathy_Homo sapiens_hsa054141.47727308
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.44626851
13Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41722046
14Olfactory transduction_Homo sapiens_hsa047401.40006262
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.34950116
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.34607367
17Acute myeloid leukemia_Homo sapiens_hsa052211.33706489
18Gastric acid secretion_Homo sapiens_hsa049711.29104223
19Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.29021632
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.28288485
21Malaria_Homo sapiens_hsa051441.28217496
22Renin secretion_Homo sapiens_hsa049241.24975234
23Oxytocin signaling pathway_Homo sapiens_hsa049211.24859172
24Osteoclast differentiation_Homo sapiens_hsa043801.23714939
25ECM-receptor interaction_Homo sapiens_hsa045121.22029422
26Salivary secretion_Homo sapiens_hsa049701.20461764
27Prion diseases_Homo sapiens_hsa050201.20139692
28Calcium signaling pathway_Homo sapiens_hsa040201.18048975
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17805193
30Morphine addiction_Homo sapiens_hsa050321.17792197
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.15361334
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.14932268
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.13853664
34B cell receptor signaling pathway_Homo sapiens_hsa046621.13454586
35Focal adhesion_Homo sapiens_hsa045101.13299068
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12318561
37Circadian entrainment_Homo sapiens_hsa047131.10269305
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09365327
39ErbB signaling pathway_Homo sapiens_hsa040121.08565296
40Insulin secretion_Homo sapiens_hsa049111.07198151
41Axon guidance_Homo sapiens_hsa043601.06560235
42Glioma_Homo sapiens_hsa052141.05662308
43Regulation of actin cytoskeleton_Homo sapiens_hsa048101.05551028
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04920363
45cAMP signaling pathway_Homo sapiens_hsa040241.04625085
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04417987
47Bladder cancer_Homo sapiens_hsa052191.04255489
48Hepatitis C_Homo sapiens_hsa051601.02504330
49Amoebiasis_Homo sapiens_hsa051461.02418484
50Insulin signaling pathway_Homo sapiens_hsa049101.01780233
51VEGF signaling pathway_Homo sapiens_hsa043701.00735816
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99614758
53Small cell lung cancer_Homo sapiens_hsa052220.98989103
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98851689
55Long-term potentiation_Homo sapiens_hsa047200.98638607
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.97869040
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.97859879
58Cholinergic synapse_Homo sapiens_hsa047250.97135891
59Amphetamine addiction_Homo sapiens_hsa050310.96279237
60mTOR signaling pathway_Homo sapiens_hsa041500.95772127
61Staphylococcus aureus infection_Homo sapiens_hsa051500.93842138
62Inositol phosphate metabolism_Homo sapiens_hsa005620.93739714
63Insulin resistance_Homo sapiens_hsa049310.93350204
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.92175843
65Nicotine addiction_Homo sapiens_hsa050330.91947853
66Glutamatergic synapse_Homo sapiens_hsa047240.91250696
67Chemokine signaling pathway_Homo sapiens_hsa040620.88928401
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.87915526
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86381438
70Lysosome_Homo sapiens_hsa041420.86195796
71Estrogen signaling pathway_Homo sapiens_hsa049150.85775721
72Protein digestion and absorption_Homo sapiens_hsa049740.85449680
73MAPK signaling pathway_Homo sapiens_hsa040100.84999486
74Dopaminergic synapse_Homo sapiens_hsa047280.84559819
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83887161
76Rap1 signaling pathway_Homo sapiens_hsa040150.83801826
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.83792906
78Renal cell carcinoma_Homo sapiens_hsa052110.83483570
79Tuberculosis_Homo sapiens_hsa051520.82686219
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81820198
81Platelet activation_Homo sapiens_hsa046110.81680767
82GnRH signaling pathway_Homo sapiens_hsa049120.81503854
83Taste transduction_Homo sapiens_hsa047420.81180817
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80015251
85Toxoplasmosis_Homo sapiens_hsa051450.79914005
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79501937
87African trypanosomiasis_Homo sapiens_hsa051430.78397185
88Glucagon signaling pathway_Homo sapiens_hsa049220.78179121
89Melanoma_Homo sapiens_hsa052180.77850354
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77756101
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77664916
92Endometrial cancer_Homo sapiens_hsa052130.77481723
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77313203
94Chronic myeloid leukemia_Homo sapiens_hsa052200.77051842
95Prolactin signaling pathway_Homo sapiens_hsa049170.76235282
96Pancreatic cancer_Homo sapiens_hsa052120.76129021
97Phagosome_Homo sapiens_hsa041450.76073453
98Ras signaling pathway_Homo sapiens_hsa040140.75753804
99Proteoglycans in cancer_Homo sapiens_hsa052050.73567241
100Pertussis_Homo sapiens_hsa051330.71537895
101Non-small cell lung cancer_Homo sapiens_hsa052230.70890349
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.70505992
103Salmonella infection_Homo sapiens_hsa051320.70481981
104Phototransduction_Homo sapiens_hsa047440.70372069
105Endocytosis_Homo sapiens_hsa041440.69889978
106Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69809426
107Rheumatoid arthritis_Homo sapiens_hsa053230.69611442
108Ovarian steroidogenesis_Homo sapiens_hsa049130.69518143
109T cell receptor signaling pathway_Homo sapiens_hsa046600.68785299
110ABC transporters_Homo sapiens_hsa020100.68719817
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68573433
112Measles_Homo sapiens_hsa051620.68389613
113Hepatitis B_Homo sapiens_hsa051610.68145178
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67515112
115Sphingolipid metabolism_Homo sapiens_hsa006000.66427778
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66203909
117Lysine degradation_Homo sapiens_hsa003100.66016440
118Apoptosis_Homo sapiens_hsa042100.65397029
119Graft-versus-host disease_Homo sapiens_hsa053320.65175909
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.65062875
121Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64706288
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64600044
123FoxO signaling pathway_Homo sapiens_hsa040680.64545075
124Leishmaniasis_Homo sapiens_hsa051400.64279517
125Choline metabolism in cancer_Homo sapiens_hsa052310.63425804
126Influenza A_Homo sapiens_hsa051640.63273228
127Allograft rejection_Homo sapiens_hsa053300.63048547
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.62728027
129Hematopoietic cell lineage_Homo sapiens_hsa046400.60895945
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.58868019
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55975111
132HIF-1 signaling pathway_Homo sapiens_hsa040660.55552997

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