SPTSSA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Serine palmitoyltransferase (SPT; EC 2.3.1.50) catalyzes the first committed and rate-limiting step in sphingolipid biosynthesis. SSSPTA is a small SPT subunit that stimulates SPT activity and confers acyl-CoA preference to the SPT catalytic heterodimer of SPTLC1 (MIM 605712) and either SPTLC2 (MIM 605713) or SPTLC3 (MIM 611120) (Han et al., 2009 [PubMed 19416851]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.99030079
2viral transcription (GO:0019083)6.06128572
3translational termination (GO:0006415)5.83432018
4SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.77204186
5cotranslational protein targeting to membrane (GO:0006613)5.72120700
6protein targeting to ER (GO:0045047)5.66222944
7protein localization to endoplasmic reticulum (GO:0070972)5.43893969
8establishment of protein localization to endoplasmic reticulum (GO:0072599)5.39887209
9ribosomal small subunit biogenesis (GO:0042274)5.39378821
10translational elongation (GO:0006414)4.91377909
11viral life cycle (GO:0019058)4.62897249
12L-phenylalanine metabolic process (GO:0006558)4.49301603
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.49301603
14signal peptide processing (GO:0006465)4.43679213
15cellular protein complex disassembly (GO:0043624)4.34334435
16DNA deamination (GO:0045006)4.25748445
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.25388465
18maturation of SSU-rRNA (GO:0030490)4.23883955
19negative regulation of protein activation cascade (GO:2000258)4.15185698
20regulation of protein activation cascade (GO:2000257)4.02867966
21translational initiation (GO:0006413)4.02257384
22regulation of complement activation (GO:0030449)3.99793175
23negative regulation of complement activation (GO:0045916)3.95988545
24platelet dense granule organization (GO:0060155)3.90319838
25L-phenylalanine catabolic process (GO:0006559)3.86940633
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.86940633
27blood coagulation, intrinsic pathway (GO:0007597)3.83287109
28protein targeting to membrane (GO:0006612)3.81412292
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.80654149
30very-low-density lipoprotein particle assembly (GO:0034379)3.76433547
31ribosomal large subunit biogenesis (GO:0042273)3.76202177
32regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.69598589
33protein complex disassembly (GO:0043241)3.63306048
34protein maturation by protein folding (GO:0022417)3.58029565
35intestinal cholesterol absorption (GO:0030299)3.56327040
36antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.55014308
37antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.55014308
38COPI coating of Golgi vesicle (GO:0048205)3.51117730
39Golgi transport vesicle coating (GO:0048200)3.51117730
40regulation of fibrinolysis (GO:0051917)3.50850095
41negative regulation of fibrinolysis (GO:0051918)3.47992068
42translation (GO:0006412)3.47128960
43macromolecular complex disassembly (GO:0032984)3.40868183
44protein carboxylation (GO:0018214)3.38433276
45peptidyl-glutamic acid carboxylation (GO:0017187)3.38433276
46low-density lipoprotein particle remodeling (GO:0034374)3.31994332
47desmosome organization (GO:0002934)3.28372818
48regulation of cholesterol esterification (GO:0010872)3.23218831
49respiratory chain complex IV assembly (GO:0008535)3.20695059
50nuclear-transcribed mRNA catabolic process (GO:0000956)3.20208960
51deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.18787616
52proteasome assembly (GO:0043248)3.16569815
53telomere maintenance via semi-conservative replication (GO:0032201)3.10302127
54daunorubicin metabolic process (GO:0044597)3.06567279
55polyketide metabolic process (GO:0030638)3.06567279
56doxorubicin metabolic process (GO:0044598)3.06567279
57mRNA catabolic process (GO:0006402)3.06223959
58antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.04311692
59GPI anchor biosynthetic process (GO:0006506)3.04213152
60antigen processing and presentation of endogenous antigen (GO:0019883)3.02823175
61response to interferon-beta (GO:0035456)3.00579799
62surfactant homeostasis (GO:0043129)3.00354276
63bundle of His cell to Purkinje myocyte communication (GO:0086069)2.99968884
64fibrinolysis (GO:0042730)2.96603972
65antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.93827006
66high-density lipoprotein particle remodeling (GO:0034375)2.92052884
67neutrophil activation involved in immune response (GO:0002283)2.91931359
68negative regulation of norepinephrine secretion (GO:0010700)2.88959327
69triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.87408722
70regulation of cholesterol biosynthetic process (GO:0045540)2.87039267
71fucose catabolic process (GO:0019317)2.84962027
72L-fucose metabolic process (GO:0042354)2.84962027
73L-fucose catabolic process (GO:0042355)2.84962027
74plasma lipoprotein particle assembly (GO:0034377)2.83993756
75mannosylation (GO:0097502)2.82680750
76fatty acid elongation (GO:0030497)2.80716189
77mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.80669601
78protein-lipid complex remodeling (GO:0034368)2.79875078
79macromolecular complex remodeling (GO:0034367)2.79875078
80plasma lipoprotein particle remodeling (GO:0034369)2.79875078
81reverse cholesterol transport (GO:0043691)2.79082586
82ribonucleoprotein complex biogenesis (GO:0022613)2.77898157
83intestinal absorption (GO:0050892)2.77291950
84COPII vesicle coating (GO:0048208)2.77257170
85RNA catabolic process (GO:0006401)2.77175044
86proline biosynthetic process (GO:0006561)2.74969411
87lymphoid progenitor cell differentiation (GO:0002320)2.74715165
88definitive hemopoiesis (GO:0060216)2.74503718
89telomere maintenance via recombination (GO:0000722)2.73033290
90L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.71501379
91DNA strand elongation involved in DNA replication (GO:0006271)2.68658219
92termination of RNA polymerase III transcription (GO:0006386)2.65953941
93transcription elongation from RNA polymerase III promoter (GO:0006385)2.65953941
94L-ascorbic acid metabolic process (GO:0019852)2.63415214
95cholesterol efflux (GO:0033344)2.62774366
96regulation of apoptotic cell clearance (GO:2000425)2.62489851
97ER overload response (GO:0006983)2.62343224
98aminoglycoside antibiotic metabolic process (GO:0030647)2.61783969
99nucleotide-sugar biosynthetic process (GO:0009226)2.61652810
100cholesterol biosynthetic process (GO:0006695)2.60492868
101establishment of protein localization to membrane (GO:0090150)2.59262352
102cytochrome complex assembly (GO:0017004)2.59082875
103DNA strand elongation (GO:0022616)2.58481242
104proline metabolic process (GO:0006560)2.51787868
105cellular zinc ion homeostasis (GO:0006882)2.51252649
106antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.50395024
107regulation of respiratory burst (GO:0060263)2.49975696
108cellular component biogenesis (GO:0044085)2.49750602
109mast cell activation (GO:0045576)2.48943746
110negative regulation of coagulation (GO:0050819)2.48652734
111sterol biosynthetic process (GO:0016126)2.48595000
112negative regulation of hemostasis (GO:1900047)2.48142189
113negative regulation of blood coagulation (GO:0030195)2.48142189
114negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.47619307
115intestinal epithelial cell development (GO:0060576)2.46109969
116positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.45812405
117negative regulation of humoral immune response (GO:0002921)2.45340070
118GPI anchor metabolic process (GO:0006505)2.45279512
119regulation of cholesterol homeostasis (GO:2000188)2.44721202
120protein targeting (GO:0006605)2.44644279
121regulation of integrin-mediated signaling pathway (GO:2001044)2.43991594
122exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.43097099
1234-hydroxyproline metabolic process (GO:0019471)2.42882840
124formation of translation preinitiation complex (GO:0001731)2.42853464
125regulation of cellular amino acid metabolic process (GO:0006521)2.41842272
126mitochondrial respiratory chain complex I assembly (GO:0032981)2.41790814
127NADH dehydrogenase complex assembly (GO:0010257)2.41790814
128mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.41790814
129ribosome assembly (GO:0042255)2.41471586
130positive regulation of chemokine secretion (GO:0090197)2.40832207
131chemical homeostasis within a tissue (GO:0048875)2.40801728
132preassembly of GPI anchor in ER membrane (GO:0016254)2.40629888
133positive regulation of cellular amine metabolic process (GO:0033240)2.40396137
134plasma lipoprotein particle organization (GO:0071827)2.39950885
135gap junction assembly (GO:0016264)2.39935615
136negative regulation of transcription by competitive promoter binding (GO:0010944)2.39809580
137sphingoid metabolic process (GO:0046519)2.39773026
138pseudouridine synthesis (GO:0001522)2.39755442
139nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.39335781
140DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.38552942
141zinc ion transmembrane transport (GO:0071577)2.36805505
142protein-lipid complex assembly (GO:0065005)2.36611756
143plasma lipoprotein particle clearance (GO:0034381)2.36500068
144protein neddylation (GO:0045116)2.36055435
145amyloid precursor protein catabolic process (GO:0042987)2.35798688
146regulation of metalloenzyme activity (GO:0048552)2.35719483
147positive regulation of B cell differentiation (GO:0045579)2.35089160
148positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.35009031
149peptidyl-histidine modification (GO:0018202)2.34973720
150sterol transport (GO:0015918)2.34668759
151cholesterol transport (GO:0030301)2.34668759
152alpha-linolenic acid metabolic process (GO:0036109)2.34166418
153signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.33774551
154intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.33774551
155mitotic recombination (GO:0006312)2.33768376
156regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.33255798
157positive regulation of T cell mediated cytotoxicity (GO:0001916)2.33237809
158positive regulation of respiratory burst (GO:0060267)2.33029270
159purine ribonucleotide transport (GO:0015868)2.32748638
160cysteine metabolic process (GO:0006534)2.32525783
161primary alcohol catabolic process (GO:0034310)2.32524260
162fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.31998357
163negative regulation of ligase activity (GO:0051352)2.31596624
164negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.31596624
165purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.31592358
166rRNA processing (GO:0006364)2.31207100
167cellular copper ion homeostasis (GO:0006878)2.30481548
168tyrosine metabolic process (GO:0006570)2.30227650
169protein complex biogenesis (GO:0070271)2.30094566
170retinal metabolic process (GO:0042574)2.30068703
171antigen processing and presentation via MHC class Ib (GO:0002475)2.29958622
172signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.29949600
173signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.29949600
174signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.29949600
175negative regulation of wound healing (GO:0061045)2.29637472
176regulation of mitochondrial translation (GO:0070129)2.29355999
177fructose metabolic process (GO:0006000)2.29029271
178cellular glucuronidation (GO:0052695)2.28622442
179C-terminal protein lipidation (GO:0006501)2.28343350
180Arp2/3 complex-mediated actin nucleation (GO:0034314)2.28223262
181negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.28095134
182long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.26262157
183tricarboxylic acid cycle (GO:0006099)2.24325242
184nucleobase-containing small molecule interconversion (GO:0015949)2.24091464
185maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.22780226
186protein hydroxylation (GO:0018126)2.21931473
187establishment of integrated proviral latency (GO:0075713)2.21832249
188water-soluble vitamin biosynthetic process (GO:0042364)2.21123365
189uronic acid metabolic process (GO:0006063)2.20456981
190glucuronate metabolic process (GO:0019585)2.20456981
191glycoside metabolic process (GO:0016137)2.19682149
192peptidyl-proline hydroxylation (GO:0019511)2.19400330
193UDP-N-acetylglucosamine metabolic process (GO:0006047)2.18948163
194pteridine-containing compound biosynthetic process (GO:0042559)2.18347558
195membrane budding (GO:0006900)2.18259542
196protein activation cascade (GO:0072376)2.17742535

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.64229447
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.07790132
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.39616171
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.30048279
5AR_21909140_ChIP-Seq_LNCAP_Human3.25601745
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.23918990
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.18208193
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.96372446
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.92590202
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.88827399
11ZNF263_19887448_ChIP-Seq_K562_Human2.88709715
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.84969182
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.83988893
14SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.73216391
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.69903663
16E2F7_22180533_ChIP-Seq_HELA_Human2.68275658
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.63360150
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.58758930
19CLOCK_20551151_ChIP-Seq_293T_Human2.56069883
20HIF1A_21447827_ChIP-Seq_MCF-7_Human2.53157069
21PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.44186373
22RXR_22158963_ChIP-Seq_LIVER_Mouse2.37289511
23ESR1_21235772_ChIP-Seq_MCF-7_Human2.36401847
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35246579
25SCL_19346495_ChIP-Seq_HPC-7_Human2.35037324
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.33926184
27ETS1_20019798_ChIP-Seq_JURKAT_Human2.31332151
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.31136203
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.29160451
30IRF8_21731497_ChIP-ChIP_J774_Mouse2.25328339
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.20959941
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18622934
33ERG_20887958_ChIP-Seq_HPC-7_Mouse2.17868930
34VDR_23849224_ChIP-Seq_CD4+_Human2.17241071
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.14977800
36MYC_18358816_ChIP-ChIP_MESCs_Mouse2.14364995
37HOXB4_20404135_ChIP-ChIP_EML_Mouse2.12559698
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.09489881
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01914662
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.98810934
41SPI1_23547873_ChIP-Seq_NB4_Human1.98644267
42GATA1_22025678_ChIP-Seq_K562_Human1.98460711
43TP63_17297297_ChIP-ChIP_HaCaT_Human1.93615768
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.92300781
45ESR1_15608294_ChIP-ChIP_MCF-7_Human1.89888462
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.87865675
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.86104604
48LXR_22158963_ChIP-Seq_LIVER_Mouse1.85225496
49ELK1_19687146_ChIP-ChIP_HELA_Human1.84230647
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.83750629
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.83587221
52TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83405755
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.80536931
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.79799544
55PPARA_22158963_ChIP-Seq_LIVER_Mouse1.76939701
56FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.75469104
57FOXP3_21729870_ChIP-Seq_TREG_Human1.74739350
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.73949749
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.73011485
60MYC_19030024_ChIP-ChIP_MESCs_Mouse1.70116109
61GATA4_25053715_ChIP-Seq_YYC3_Human1.69768046
62STAT4_19710469_ChIP-ChIP_TH1__Mouse1.69621476
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.69543975
64DCP1A_22483619_ChIP-Seq_HELA_Human1.68972789
65SOX2_20726797_ChIP-Seq_SW620_Human1.66153449
66CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.65977666
67XRN2_22483619_ChIP-Seq_HELA_Human1.64958104
68BP1_19119308_ChIP-ChIP_Hs578T_Human1.64060992
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.62812133
70SALL4_18804426_ChIP-ChIP_XEN_Mouse1.61692512
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.60962917
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.60439300
73GATA3_24758297_ChIP-Seq_MCF-7_Human1.55389224
74SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.55321916
75MYC_19079543_ChIP-ChIP_MESCs_Mouse1.54596982
76PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.53880326
77NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.52221318
78SOX17_20123909_ChIP-Seq_XEN_Mouse1.51897250
79SOX2_27498859_Chip-Seq_STOMACH_Mouse1.47920287
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.47089009
81TRIM28_21343339_ChIP-Seq_HEK293_Human1.44493074
82SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.44342613
83STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44212157
84CDX2_20551321_ChIP-Seq_CACO-2_Human1.41717929
85TTF2_22483619_ChIP-Seq_HELA_Human1.39332057
86NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37931923
87NELFA_20434984_ChIP-Seq_ESCs_Mouse1.37015122
88GATA6_25053715_ChIP-Seq_YYC3_Human1.36802517
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.35215010
90EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.34887698
91MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34497546
92FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.34252386
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.34164778
94GABP_19822575_ChIP-Seq_HepG2_Human1.33969677
95SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32533161
96ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31196270
97FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.31121480
98ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.30038144
99MYB_26560356_Chip-Seq_TH2_Human1.29459082
100LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.28095220
101E2F4_17652178_ChIP-ChIP_JURKAT_Human1.28041715
102GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26979126
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.26962929
104IRF8_27001747_Chip-Seq_BMDM_Mouse1.25477843
105FOXM1_26456572_ChIP-Seq_MCF-7_Human1.23413069
106IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.23231740
107ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22637570
108NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22483878
109CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20372972
110ELF5_23300383_ChIP-Seq_T47D_Human1.18315992
111GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18050726
112NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17782531
113FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17710497
114RUNX1_22412390_ChIP-Seq_EML_Mouse1.16423197
115EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16133622
116RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15942893
117FOXA2_19822575_ChIP-Seq_HepG2_Human1.14314785
118PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13406535
119ELK1_22589737_ChIP-Seq_MCF10A_Human1.13378798
120VDR_24763502_ChIP-Seq_THP-1_Human1.12722533
121TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.12042798
122ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09739939
123STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09676807
124ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09447465
125SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.09205464
126HNF4A_19822575_ChIP-Seq_HepG2_Human1.08995914
127CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08961950
128KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.08779875
129KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07958122
130GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07097790
131ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.06108068
132NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05729874
133TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05502493
134VDR_21846776_ChIP-Seq_THP-1_Human1.05242311
135TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04929591
136PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04545298
137BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03023217
138FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.03011487
139HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02450005
140SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02361684
141SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02361684
142EOMES_21245162_ChIP-Seq_HESCs_Human1.02311466
143MYB_26560356_Chip-Seq_TH1_Human1.00292767
144FOXM1_23109430_ChIP-Seq_U2OS_Human1.00086606
145CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99961322
146STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99099073
147MYC_18940864_ChIP-ChIP_HL60_Human0.98883423
148ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97197527
149MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96780163
150CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96262385
151HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92849682
152PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92838475
153CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90504210
154THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90329579
155IRF1_19129219_ChIP-ChIP_H3396_Human0.90022224
156PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.89971183
157CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88471323
158YY1_21170310_ChIP-Seq_MESCs_Mouse0.87560102
159HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87188967
160CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86963619
161PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85298867

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.52429674
2MP0002139_abnormal_hepatobiliary_system3.53880978
3MP0009379_abnormal_foot_pigmentation3.33360890
4MP0001835_abnormal_antigen_presentation3.14699969
5MP0005365_abnormal_bile_salt2.97515858
6MP0009780_abnormal_chondrocyte_physiolo2.91384558
7MP0006054_spinal_hemorrhage2.85689305
8MP0002396_abnormal_hematopoietic_system2.77890211
9MP0009785_altered_susceptibility_to2.77168189
10MP0003724_increased_susceptibility_to2.57355867
11MP0002148_abnormal_hypersensitivity_rea2.46730100
12MP0003868_abnormal_feces_composition2.46639418
13MP0008875_abnormal_xenobiotic_pharmacok2.45111989
14MP0005085_abnormal_gallbladder_physiolo2.42315116
15MP0000465_gastrointestinal_hemorrhage2.40698992
16MP0003941_abnormal_skin_development2.40478610
17MP0005671_abnormal_response_to2.36820062
18MP0003122_maternal_imprinting2.36095023
19MP0004381_abnormal_hair_follicle2.30535743
20MP0010329_abnormal_lipoprotein_level2.28492858
21MP0005025_abnormal_response_to2.28329006
22MP0003123_paternal_imprinting2.28309019
23MP0002877_abnormal_melanocyte_morpholog2.20111634
24MP0000685_abnormal_immune_system2.19848667
25MP0005075_abnormal_melanosome_morpholog2.17513832
26MP0002166_altered_tumor_susceptibility2.07831313
27MP0003763_abnormal_thymus_physiology2.04987689
28MP0005000_abnormal_immune_tolerance2.04088006
29MP0003195_calcinosis1.98984500
30MP0004272_abnormal_basement_membrane1.96364028
31MP0002419_abnormal_innate_immunity1.95962476
32MP0004264_abnormal_extraembryonic_tissu1.95327795
33MP0003436_decreased_susceptibility_to1.93898862
34MP0005464_abnormal_platelet_physiology1.91963669
35MP0002723_abnormal_immune_serum1.88695606
36MP0003186_abnormal_redox_activity1.88643497
37MP0002420_abnormal_adaptive_immunity1.82927000
38MP0002452_abnormal_antigen_presenting1.82036868
39MP0001819_abnormal_immune_cell1.79896328
40MP0001800_abnormal_humoral_immune1.79615919
41MP0005174_abnormal_tail_pigmentation1.79307915
42MP0003566_abnormal_cell_adhesion1.76880802
43MP0009333_abnormal_splenocyte_physiolog1.74935708
44MP0003693_abnormal_embryo_hatching1.69312832
45MP0004147_increased_porphyrin_level1.66659104
46MP0000490_abnormal_crypts_of1.63634301
47MP0001545_abnormal_hematopoietic_system1.60160747
48MP0005397_hematopoietic_system_phenotyp1.60160747
49MP0005332_abnormal_amino_acid1.58503527
50MP0002006_tumorigenesis1.54551163
51MP0010155_abnormal_intestine_physiology1.53998871
52MP0005360_urolithiasis1.53570104
53MP0001853_heart_inflammation1.53362908
54MP0002796_impaired_skin_barrier1.53121594
55MP0005387_immune_system_phenotype1.53085967
56MP0001790_abnormal_immune_system1.53085967
57MP0002398_abnormal_bone_marrow1.52128492
58MP0000372_irregular_coat_pigmentation1.49015915
59MP0000716_abnormal_immune_system1.45875288
60MP0002095_abnormal_skin_pigmentation1.43739265
61MP0004947_skin_inflammation1.43131856
62MP0005083_abnormal_biliary_tract1.42839455
63MP0002909_abnormal_adrenal_gland1.40760463
64MP0003656_abnormal_erythrocyte_physiolo1.39614154
65MP0000689_abnormal_spleen_morphology1.38639899
66MP0006082_CNS_inflammation1.36540136
67MP0002722_abnormal_immune_system1.35885092
68MP0002132_abnormal_respiratory_system1.35475096
69MP0001845_abnormal_inflammatory_respons1.35323077
70MP0002009_preneoplasia1.35050952
71MP0002429_abnormal_blood_cell1.33492300
72MP0001873_stomach_inflammation1.33143125
73MP0008469_abnormal_protein_level1.30962201
74MP0005257_abnormal_intraocular_pressure1.29841638
75MP0002405_respiratory_system_inflammati1.28011668
76MP0003806_abnormal_nucleotide_metabolis1.25995148
77MP0003315_abnormal_perineum_morphology1.25587579
78MP0005058_abnormal_lysosome_morphology1.25213715
79MP0002060_abnormal_skin_morphology1.24654125
80MP0008932_abnormal_embryonic_tissue1.22408041
81MP0003191_abnormal_cellular_cholesterol1.20520169
82MP0000566_synostosis1.20082348
83MP0003718_maternal_effect1.19474203
84MP0000383_abnormal_hair_follicle1.19361744
85MP0003866_abnormal_defecation1.18975116
86MP0003011_delayed_dark_adaptation1.18746119
87MP0004957_abnormal_blastocyst_morpholog1.17487600
88MP0005501_abnormal_skin_physiology1.17368073
89MP0005409_darkened_coat_color1.16180450
90MP0008007_abnormal_cellular_replicative1.15010316
91MP0001216_abnormal_epidermal_layer1.13132229
92MP0003950_abnormal_plasma_membrane1.12845993
93MP0010352_gastrointestinal_tract_polyps1.11797668
94MP0002118_abnormal_lipid_homeostasis1.11759868
95MP0001533_abnormal_skeleton_physiology1.08938969
96MP0000920_abnormal_myelination1.08907713
97MP0006035_abnormal_mitochondrial_morpho1.07324335
98MP0000013_abnormal_adipose_tissue1.06829154
99MP0000627_abnormal_mammary_gland1.06669861
100MP0008438_abnormal_cutaneous_collagen1.05808322
101MP0002933_joint_inflammation1.05619893
102MP0001881_abnormal_mammary_gland1.04666486
103MP0005408_hypopigmentation1.04503156
104MP0004808_abnormal_hematopoietic_stem1.04474566
105MP0001764_abnormal_homeostasis1.04222258
106MP0001986_abnormal_taste_sensitivity1.03640429
107MP0005187_abnormal_penis_morphology1.03282938
108MP0003638_abnormal_response/metabolism_1.03017424
109MP0000609_abnormal_liver_physiology1.02943649
110MP0001851_eye_inflammation1.00557164
111MP0000358_abnormal_cell_content/0.98884979
112MP0000579_abnormal_nail_morphology0.97522003
113MP0004782_abnormal_surfactant_physiolog0.94766384
114MP0002098_abnormal_vibrissa_morphology0.93567403
115MP0003453_abnormal_keratinocyte_physiol0.92668614
116MP0002938_white_spotting0.92244074
117MP0000858_altered_metastatic_potential0.91001182
118MP0009697_abnormal_copulation0.90711795
119MP0010094_abnormal_chromosome_stability0.90337686
120MP0009672_abnormal_birth_weight0.89949855
121MP0001666_abnormal_nutrient_absorption0.89571846
122MP0000343_altered_response_to0.89561890
123MP0000647_abnormal_sebaceous_gland0.89216863
124MP0000003_abnormal_adipose_tissue0.89207837
125MP0004019_abnormal_vitamin_homeostasis0.88970038
126MP0000681_abnormal_thyroid_gland0.88957016
127MP0000703_abnormal_thymus_morphology0.88875825
128MP0001756_abnormal_urination0.88621345
129MP0003183_abnormal_peptide_metabolism0.86131244
130MP0003890_abnormal_embryonic-extraembry0.85933972
131MP0001730_embryonic_growth_arrest0.85480209
132MP0005451_abnormal_body_composition0.85311478
133MP0002019_abnormal_tumor_incidence0.84655885
134MP0002160_abnormal_reproductive_system0.83462661
135MP0005084_abnormal_gallbladder_morpholo0.83377299
136MP0002089_abnormal_postnatal_growth/wei0.83228094
137MP0000467_abnormal_esophagus_morphology0.83065856
138MP0005275_abnormal_skin_tensile0.82753302
139MP0010678_abnormal_skin_adnexa0.82425328
140MP0005248_abnormal_Harderian_gland0.82273747
141MP0005636_abnormal_mineral_homeostasis0.82163093
142MP0001191_abnormal_skin_condition0.81883756
143MP0010771_integument_phenotype0.81784144
144MP0001915_intracranial_hemorrhage0.81615808
145MP0001697_abnormal_embryo_size0.80747864
146MP0000537_abnormal_urethra_morphology0.80566509
147MP0000377_abnormal_hair_follicle0.80284287
148MP0001661_extended_life_span0.79764694
149MP0003252_abnormal_bile_duct0.79687455
150MP0009840_abnormal_foam_cell0.79501273
151MP0006036_abnormal_mitochondrial_physio0.78960402
152MP0009763_increased_sensitivity_to0.78378421
153MP0002697_abnormal_eye_size0.77042955
154MP0005220_abnormal_exocrine_pancreas0.76857470
155MP0001243_abnormal_dermal_layer0.75897390
156MP0009643_abnormal_urine_homeostasis0.75727528
157MP0009931_abnormal_skin_appearance0.75370316
158MP0002086_abnormal_extraembryonic_tissu0.73797530
159MP0003984_embryonic_growth_retardation0.72972376
160MP0000639_abnormal_adrenal_gland0.71647771
161MP0002896_abnormal_bone_mineralization0.70797914
162MP0002088_abnormal_embryonic_growth/wei0.69721786
163MP0005380_embryogenesis_phenotype0.69465368
164MP0001672_abnormal_embryogenesis/_devel0.69465368
165MP0003942_abnormal_urinary_system0.69245840
166MP0010368_abnormal_lymphatic_system0.69194193
167MP0009053_abnormal_anal_canal0.69038060
168MP0003136_yellow_coat_color0.68591527
169MP0005410_abnormal_fertilization0.67301070
170MP0002295_abnormal_pulmonary_circulatio0.66775654
171MP0005076_abnormal_cell_differentiation0.65991747
172MP0002090_abnormal_vision0.64531463

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.51105503
2Abnormality of cells of the erythroid lineage (HP:0012130)5.35499957
3Abnormal number of erythroid precursors (HP:0012131)5.09054087
4Prolonged partial thromboplastin time (HP:0003645)4.79219589
5Reticulocytopenia (HP:0001896)4.26173516
6Thrombocytosis (HP:0001894)3.90627300
7Elevated erythrocyte sedimentation rate (HP:0003565)3.86529966
8Increased serum pyruvate (HP:0003542)3.75764317
9Hypobetalipoproteinemia (HP:0003563)3.73187113
10Abnormality of glycolysis (HP:0004366)3.65247252
11Aplastic anemia (HP:0001915)3.62451208
12Type I transferrin isoform profile (HP:0003642)3.59231809
13Reduced antithrombin III activity (HP:0001976)3.55388299
14Vascular calcification (HP:0004934)3.37919888
15IgM deficiency (HP:0002850)3.34678070
16Macrocytic anemia (HP:0001972)3.29442350
17Petechiae (HP:0000967)3.29337915
18Vacuolated lymphocytes (HP:0001922)3.26237240
19Asymmetry of the thorax (HP:0001555)3.25435602
20Glomerulonephritis (HP:0000099)3.20273366
21Complement deficiency (HP:0004431)3.19687567
22Pallor (HP:0000980)3.19395139
23Abnormality of the common coagulation pathway (HP:0010990)3.15975318
24Recurrent abscess formation (HP:0002722)3.15052843
25Hypoglycemic coma (HP:0001325)3.14786343
26Abnormality of methionine metabolism (HP:0010901)3.07612731
27Chronic otitis media (HP:0000389)3.04196018
28Abnormal protein glycosylation (HP:0012346)3.03300147
29Abnormal glycosylation (HP:0012345)3.03300147
30Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.03300147
31Abnormal protein N-linked glycosylation (HP:0012347)3.03300147
32Myositis (HP:0100614)3.00828448
33Hepatocellular necrosis (HP:0001404)2.99149030
34Hepatic necrosis (HP:0002605)2.98703746
353-Methylglutaconic aciduria (HP:0003535)2.96467895
36Right ventricular cardiomyopathy (HP:0011663)2.94767184
37Parakeratosis (HP:0001036)2.92347511
38Aplasia/Hypoplasia of the sacrum (HP:0008517)2.92224736
39Renal Fanconi syndrome (HP:0001994)2.90223874
40Increased hepatocellular lipid droplets (HP:0006565)2.89793290
41Cardiovascular calcification (HP:0011915)2.88437549
42Abnormality of monocarboxylic acid metabolism (HP:0010996)2.86825724
43Recurrent bacterial skin infections (HP:0005406)2.86077529
44Xanthomatosis (HP:0000991)2.84429770
45Menorrhagia (HP:0000132)2.84199033
46Lipid accumulation in hepatocytes (HP:0006561)2.81597160
47Erythema (HP:0010783)2.81555077
48Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.81098173
49Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.74138520
50Decreased activity of mitochondrial respiratory chain (HP:0008972)2.74138520
51Intrahepatic cholestasis (HP:0001406)2.70389871
52Joint hemorrhage (HP:0005261)2.63172951
53Mitochondrial inheritance (HP:0001427)2.62729185
54Exertional dyspnea (HP:0002875)2.62714251
55Abnormality of alanine metabolism (HP:0010916)2.59878902
56Hyperalaninemia (HP:0003348)2.59878902
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.59878902
58Hypercholesterolemia (HP:0003124)2.59114140
59Abnormality of macrophages (HP:0004311)2.51089428
60Congenital ichthyosiform erythroderma (HP:0007431)2.49575663
61Hypolipoproteinemia (HP:0010981)2.48700696
62Abnormality of the heme biosynthetic pathway (HP:0010472)2.46998921
63Abnormal tarsal ossification (HP:0008369)2.43493083
64Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.43224263
65Abnormality of complement system (HP:0005339)2.43041439
66Increased intramyocellular lipid droplets (HP:0012240)2.41638740
67Generalized aminoaciduria (HP:0002909)2.35016176
68Megaloblastic anemia (HP:0001889)2.31947038
69Recurrent bronchitis (HP:0002837)2.31733161
70Purpura (HP:0000979)2.31547708
71Abnormality of T cell physiology (HP:0011840)2.30930672
72Systemic lupus erythematosus (HP:0002725)2.29019510
73Proximal tubulopathy (HP:0000114)2.27660013
74Patchy hypopigmentation of hair (HP:0011365)2.27519070
75Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.26977288
76Hepatosplenomegaly (HP:0001433)2.26839786
77Increased muscle lipid content (HP:0009058)2.26105344
78Spontaneous abortion (HP:0005268)2.22620953
79Increased CSF lactate (HP:0002490)2.21945302
80Small epiphyses (HP:0010585)2.20508328
81Abnormality of carpal bone ossification (HP:0006257)2.19985117
82Abnormality of the intrinsic pathway (HP:0010989)2.19495282
83Conjugated hyperbilirubinemia (HP:0002908)2.19430860
84Microcytic anemia (HP:0001935)2.19329511
85Pancytopenia (HP:0001876)2.19015084
86Abnormality of serum amino acid levels (HP:0003112)2.18244757
87B lymphocytopenia (HP:0010976)2.16991695
88Abnormality of B cell number (HP:0010975)2.16991695
89Flat acetabular roof (HP:0003180)2.16276868
90Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.16257327
91Abnormal hemoglobin (HP:0011902)2.15649800
92Hypoplasia of the capital femoral epiphysis (HP:0003090)2.13252969
93Septate vagina (HP:0001153)2.10633982
94IgG deficiency (HP:0004315)2.10006592
95Acute necrotizing encephalopathy (HP:0006965)2.09530779
96Fat malabsorption (HP:0002630)2.09469703
97Hyperammonemia (HP:0001987)2.08356884
98Abnormality of aspartate family amino acid metabolism (HP:0010899)2.06451761
99Epidermoid cyst (HP:0200040)2.05910473
100Eczematoid dermatitis (HP:0000976)2.05573001
101Prolonged bleeding time (HP:0003010)2.04996771
102Recurrent skin infections (HP:0001581)2.03754765
103Gout (HP:0001997)2.03230019
104Respiratory difficulties (HP:0002880)2.00708090
105Abnormal mitochondria in muscle tissue (HP:0008316)1.98878804
106Mitral stenosis (HP:0001718)1.98463973
107Neuroendocrine neoplasm (HP:0100634)1.97531629
108Abnormality of secondary sexual hair (HP:0009888)1.97446338
109Abnormality of the axillary hair (HP:0100134)1.97446338
110Beaking of vertebral bodies (HP:0004568)1.97252512
111Progressive neurologic deterioration (HP:0002344)1.95738838
112Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.95503390
113Microglossia (HP:0000171)1.94969302
114Autoimmune hemolytic anemia (HP:0001890)1.94667563
115Conjunctival hamartoma (HP:0100780)1.94093683
116Sparse eyelashes (HP:0000653)1.93523143
117Pheochromocytoma (HP:0002666)1.92692237
118Type 2 muscle fiber atrophy (HP:0003554)1.92656854
119Back pain (HP:0003418)1.92257962
120Hypothermia (HP:0002045)1.91903534
121Increased neuronal autofluorescent lipopigment (HP:0002074)1.91412071
122Abnormality of the prostate (HP:0008775)1.90789408
123Hypoproteinemia (HP:0003075)1.90296000
124Cerebral edema (HP:0002181)1.89428054
125Congenital, generalized hypertrichosis (HP:0004540)1.89307488
126Acute encephalopathy (HP:0006846)1.88474899
127Termporal pattern (HP:0011008)1.88456263
128Insidious onset (HP:0003587)1.88456263
129Microretrognathia (HP:0000308)1.88310778
130Acanthocytosis (HP:0001927)1.88289371
131White forelock (HP:0002211)1.86971618
132Abnormality of aromatic amino acid family metabolism (HP:0004338)1.86819821
133Epistaxis (HP:0000421)1.85427843
134Increased serum lactate (HP:0002151)1.85401217
135Gangrene (HP:0100758)1.84846853
136Abnormality of T cells (HP:0002843)1.84759570
137Microvesicular hepatic steatosis (HP:0001414)1.83858933
138Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.82554625
139Spontaneous hematomas (HP:0007420)1.82536396
140Papillary thyroid carcinoma (HP:0002895)1.81510348
141Postural tremor (HP:0002174)1.80325306
142Muscle fiber atrophy (HP:0100295)1.80267105
143Abnormality of renal resorption (HP:0011038)1.79128089
144Orchitis (HP:0100796)1.79077593
145Rickets (HP:0002748)1.79069369
146Hypergammaglobulinemia (HP:0010702)1.78292424
147Absent rod-and cone-mediated responses on ERG (HP:0007688)1.78062209
148Hypophosphatemic rickets (HP:0004912)1.77918087
149Lethargy (HP:0001254)1.77707200
150Irregular epiphyses (HP:0010582)1.76810279
151Pancreatic islet-cell hyperplasia (HP:0004510)1.76451213
152Glycosuria (HP:0003076)1.76126687
153Abnormality of urine glucose concentration (HP:0011016)1.76126687
154Symptomatic seizures (HP:0011145)1.75927745
155Hepatocellular carcinoma (HP:0001402)1.75604602
156Oral leukoplakia (HP:0002745)1.75326280
157Abnormal cartilage morphology (HP:0002763)1.75093386
158Neutropenia (HP:0001875)1.74743142
159Skin rash (HP:0000988)1.73451983
160Skin nodule (HP:0200036)1.73045974
161Uterine neoplasm (HP:0010784)1.71627604
162Recurrent viral infections (HP:0004429)1.71626726
163Lactic acidosis (HP:0003128)1.70373149
164Poor head control (HP:0002421)1.69874344
165Overlapping toe (HP:0001845)1.69780399
166Brittle hair (HP:0002299)1.69655272
167Hypoglycemic seizures (HP:0002173)1.67127400
168Meningitis (HP:0001287)1.66342581
169Retrobulbar optic neuritis (HP:0100654)1.65402545
170Optic neuritis (HP:0100653)1.65402545
171Nausea (HP:0002018)1.65036071
172Palpitations (HP:0001962)1.63444340
173Neonatal death (HP:0003811)1.63110923
174Glomerulosclerosis (HP:0000096)1.62099931
175Testicular neoplasm (HP:0010788)1.62083410
176Nephritis (HP:0000123)1.61754263
177Pterygium (HP:0001059)1.61297894
178Epiphyseal stippling (HP:0010655)1.59932540
179Hyperlipoproteinemia (HP:0010980)1.59414556
180Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.58272622

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.97428529
2STK163.18910055
3EPHA22.92711308
4KIT2.46717846
5PAK42.38490698
6FLT32.37224897
7PIM22.26350230
8TEC2.19342760
9MST42.12482823
10MAP4K12.07689828
11PDK22.01396557
12NEK11.96139966
13IRAK41.94951953
14EIF2AK31.94669763
15BTK1.89014144
16FGFR41.85008573
17PBK1.83677690
18MAPKAPK51.83482143
19VRK11.82113904
20WEE11.71822855
21STK38L1.71750631
22VRK21.71128355
23LMTK21.70110310
24ACVR1B1.68307914
25PIK3CA1.68298769
26TGFBR11.67466979
27SCYL21.66921814
28TNIK1.64037680
29LATS21.61425827
30BLK1.57437708
31KDR1.55437183
32CDK191.55254758
33TXK1.50440564
34BUB11.50424105
35FER1.50185255
36CSF1R1.49346099
37BRSK21.48560879
38BCKDK1.42184147
39TRIM281.40837893
40TTK1.39337537
41ZAP701.38416591
42STK241.36426194
43PKN21.34165770
44TBK11.34145055
45NLK1.31333079
46PASK1.30570721
47TGFBR21.30535429
48BCR1.29830352
49EIF2AK11.28287285
50JAK31.24618951
51MAP3K121.23509666
52STK31.22496985
53WNK41.22140280
54TAOK31.21921400
55IKBKE1.19597479
56RIPK11.19576636
57IRAK31.18774122
58TYK21.18614359
59MUSK1.18159935
60TESK21.17729653
61RPS6KB21.17356254
62TIE11.15548664
63TSSK61.15510102
64MST1R1.13094203
65MKNK11.12244155
66DYRK31.11934425
67PLK31.10534836
68LATS11.09563466
69FGFR11.07752571
70ERBB31.06663680
71TRPM71.05812607
72FGFR21.05583903
73ADRBK21.05364020
74PTK21.03682468
75IKBKB1.03349658
76FGFR31.03050183
77LRRK21.02598445
78SYK1.02586850
79MAPKAPK30.99838197
80BRSK10.98537877
81ITK0.98272531
82MAP3K20.97965011
83MAP3K140.97365422
84MAP3K30.96188562
85BMPR1B0.95490890
86MAP2K30.90385594
87PDGFRA0.89021747
88LYN0.87855813
89MYLK0.86923877
90CSNK1G30.85551000
91PIK3CG0.85384195
92PTK60.84223364
93PHKG10.84117844
94PHKG20.84117844
95LCK0.83310098
96SRPK10.81822264
97ARAF0.80678560
98STK390.79805526
99NME10.79640739
100MAPK150.78374447
101RPS6KA40.78065925
102MAP2K60.76817619
103CDK80.75508077
104GRK10.74581354
105ERBB40.74069504
106LIMK10.73786750
107SIK10.73288280
108NEK60.70674601
109EIF2AK20.70382984
110EPHB10.70219024
111AKT20.69977470
112INSRR0.68650758
113ILK0.68363593
114MAP2K20.68233081
115RPS6KA50.68150846
116MATK0.67354052
117CCNB10.66194809
118CLK10.64680172
119MET0.62871777
120ICK0.59603617
121OXSR10.59473489
122ERN10.59293401
123CSNK1G10.59024033
124BMX0.58975729
125TAF10.58363885
126ABL20.57500263
127NEK90.57363266
128DYRK20.57313751
129PRKCI0.56978902
130RPS6KB10.55414891
131PIM10.55358923
132AURKB0.55349657
133GRK50.54944191
134TESK10.54274689
135STK100.54032503
136CSNK1E0.53752268
137MAP3K90.53719050
138TLK10.52360294
139MAP3K110.51944125
140CSNK1A1L0.51139304
141CDK70.50540588
142IRAK10.49915834
143PLK20.49825450
144CSNK2A10.47782592
145MAPK40.47697338
146PLK10.47416654
147MAPKAPK20.46616546
148PRKG20.46515845
149CASK0.44548136
150CAMK2D0.44465991
151NUAK10.44426276
152TRIB30.43657939
153CDK60.41848260
154RPS6KA60.41008201
155YES10.39868818
156CSNK2A20.38947047
157MAP2K10.36241996
158DMPK0.36014123
159PNCK0.32996571
160CSNK1A10.31245674
161GSK3A0.30250913
162SIK30.30232120
163CSNK1G20.30144170

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.05839232
2Protein export_Homo sapiens_hsa030603.95259037
3DNA replication_Homo sapiens_hsa030303.02612038
4Proteasome_Homo sapiens_hsa030502.88915896
5Complement and coagulation cascades_Homo sapiens_hsa046102.50590103
6RNA polymerase_Homo sapiens_hsa030202.41545044
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.39155285
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.26543344
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.25708035
10Mismatch repair_Homo sapiens_hsa034302.14386341
11Folate biosynthesis_Homo sapiens_hsa007902.10449807
12Fatty acid elongation_Homo sapiens_hsa000622.00884868
13Pyrimidine metabolism_Homo sapiens_hsa002401.96300536
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.89849481
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83676531
16Homologous recombination_Homo sapiens_hsa034401.82540653
17Nitrogen metabolism_Homo sapiens_hsa009101.76173453
18Base excision repair_Homo sapiens_hsa034101.73832002
19Pyruvate metabolism_Homo sapiens_hsa006201.69597987
20Fatty acid metabolism_Homo sapiens_hsa012121.61248944
21Nucleotide excision repair_Homo sapiens_hsa034201.59326744
22Propanoate metabolism_Homo sapiens_hsa006401.58486764
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.54005819
24Fatty acid degradation_Homo sapiens_hsa000711.52514410
25Primary immunodeficiency_Homo sapiens_hsa053401.48905584
26Spliceosome_Homo sapiens_hsa030401.48875473
27Oxidative phosphorylation_Homo sapiens_hsa001901.46905105
28Non-homologous end-joining_Homo sapiens_hsa034501.44524324
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44287647
30Carbon metabolism_Homo sapiens_hsa012001.43898632
31Biosynthesis of amino acids_Homo sapiens_hsa012301.41033566
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.40865025
33Phenylalanine metabolism_Homo sapiens_hsa003601.40421424
34Other glycan degradation_Homo sapiens_hsa005111.39729869
35Sphingolipid metabolism_Homo sapiens_hsa006001.39560680
36Arginine biosynthesis_Homo sapiens_hsa002201.37986359
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.36417041
38Tyrosine metabolism_Homo sapiens_hsa003501.35488805
39Parkinsons disease_Homo sapiens_hsa050121.33926291
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.33314108
41Vitamin B6 metabolism_Homo sapiens_hsa007501.33216151
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.29957921
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28793888
44Caffeine metabolism_Homo sapiens_hsa002321.28726749
45Fat digestion and absorption_Homo sapiens_hsa049751.28200734
46Glutathione metabolism_Homo sapiens_hsa004801.27572477
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.26792924
48Arginine and proline metabolism_Homo sapiens_hsa003301.26685770
49Starch and sucrose metabolism_Homo sapiens_hsa005001.26669854
50Steroid biosynthesis_Homo sapiens_hsa001001.26555488
51Butanoate metabolism_Homo sapiens_hsa006501.23008127
52Histidine metabolism_Homo sapiens_hsa003401.22574417
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.19559995
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19058886
55Intestinal immune network for IgA production_Homo sapiens_hsa046721.19007573
56Fructose and mannose metabolism_Homo sapiens_hsa000511.18525280
57N-Glycan biosynthesis_Homo sapiens_hsa005101.17501911
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17003652
59Arachidonic acid metabolism_Homo sapiens_hsa005901.16294275
60PPAR signaling pathway_Homo sapiens_hsa033201.12926037
61Fatty acid biosynthesis_Homo sapiens_hsa000611.11209795
62Hematopoietic cell lineage_Homo sapiens_hsa046401.09575523
63Galactose metabolism_Homo sapiens_hsa000521.07980010
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06309540
65Antigen processing and presentation_Homo sapiens_hsa046121.06153815
66Mineral absorption_Homo sapiens_hsa049781.05569244
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05261802
68Legionellosis_Homo sapiens_hsa051341.03269829
69Basal transcription factors_Homo sapiens_hsa030221.02925751
70RNA degradation_Homo sapiens_hsa030181.02201867
71One carbon pool by folate_Homo sapiens_hsa006700.99972527
72Sulfur metabolism_Homo sapiens_hsa009200.99680129
73Sulfur relay system_Homo sapiens_hsa041220.99198845
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99144161
75Purine metabolism_Homo sapiens_hsa002300.98187075
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98115422
77beta-Alanine metabolism_Homo sapiens_hsa004100.95587927
78Tryptophan metabolism_Homo sapiens_hsa003800.95471583
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94667475
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93932065
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.93496130
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92468439
83Leishmaniasis_Homo sapiens_hsa051400.91836310
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90041156
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.90030288
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89164779
87Herpes simplex infection_Homo sapiens_hsa051680.86847816
88Linoleic acid metabolism_Homo sapiens_hsa005910.86214810
89Allograft rejection_Homo sapiens_hsa053300.84934549
90Alzheimers disease_Homo sapiens_hsa050100.83773502
91Ether lipid metabolism_Homo sapiens_hsa005650.82310148
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.81900170
93Vibrio cholerae infection_Homo sapiens_hsa051100.80141431
94Pertussis_Homo sapiens_hsa051330.79781740
95Pentose phosphate pathway_Homo sapiens_hsa000300.78042282
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77649302
97Huntingtons disease_Homo sapiens_hsa050160.76289149
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.75957616
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75060466
100Malaria_Homo sapiens_hsa051440.74855776
101Chemical carcinogenesis_Homo sapiens_hsa052040.74137743
102Measles_Homo sapiens_hsa051620.74037143
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.73652046
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71443975
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69769302
106Peroxisome_Homo sapiens_hsa041460.68773573
107Lysosome_Homo sapiens_hsa041420.67913679
108Metabolic pathways_Homo sapiens_hsa011000.60410728
109Bile secretion_Homo sapiens_hsa049760.59326562
110Fanconi anemia pathway_Homo sapiens_hsa034600.58984938
111Retinol metabolism_Homo sapiens_hsa008300.58287928
112Cell cycle_Homo sapiens_hsa041100.57846858
113Cyanoamino acid metabolism_Homo sapiens_hsa004600.57292185
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56818136
115Staphylococcus aureus infection_Homo sapiens_hsa051500.56777682
116p53 signaling pathway_Homo sapiens_hsa041150.56758188
117Asthma_Homo sapiens_hsa053100.56534724
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55689856
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55349742
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54529980
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.54490468
122Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54289991
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54218641
124Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50152840
125Shigellosis_Homo sapiens_hsa051310.48261045
126RNA transport_Homo sapiens_hsa030130.48090541
127Regulation of autophagy_Homo sapiens_hsa041400.47547023
128Graft-versus-host disease_Homo sapiens_hsa053320.46647811
129Selenocompound metabolism_Homo sapiens_hsa004500.46590666
130Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45766945
131ECM-receptor interaction_Homo sapiens_hsa045120.44946483
132Autoimmune thyroid disease_Homo sapiens_hsa053200.44638422
133Epstein-Barr virus infection_Homo sapiens_hsa051690.43886419
134Tight junction_Homo sapiens_hsa045300.43742653
135Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43541465
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41157508
137Rheumatoid arthritis_Homo sapiens_hsa053230.40861549
138Systemic lupus erythematosus_Homo sapiens_hsa053220.40709100
139Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40625754
140Renin-angiotensin system_Homo sapiens_hsa046140.39777520
141Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36442129
142Vitamin digestion and absorption_Homo sapiens_hsa049770.36396683
143Thyroid hormone synthesis_Homo sapiens_hsa049180.35756122
144Thyroid cancer_Homo sapiens_hsa052160.31593990
145Collecting duct acid secretion_Homo sapiens_hsa049660.31117779
146Circadian rhythm_Homo sapiens_hsa047100.29719999

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