SPTSSB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Serine palmitoyltransferase (SPT; EC 2.3.1.50) catalyzes the first committed and rate-limiting step in sphingolipid biosynthesis. SSSPTB is a small SPT subunit that stimulates SPT activity and confers acyl-CoA preference to the SPT catalytic heterodimer of SPTLC1 (MIM 605712) and either SPTLC2 (MIM 605713) or SPTLC3 (MIM 611120) (Han et al., 2009 [PubMed 19416851]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of branching involved in prostate gland morphogenesis (GO:0060687)8.28482976
2hepatocyte apoptotic process (GO:0097284)7.91826070
3digestion (GO:0007586)7.88916257
4extracellular fibril organization (GO:0043206)7.57281153
5O-glycan processing (GO:0016266)7.02387092
6positive regulation of keratinocyte differentiation (GO:0045618)7.01367916
7bundle of His cell to Purkinje myocyte communication (GO:0086069)6.97340483
8regulation of cell proliferation involved in kidney development (GO:1901722)6.94042699
9glutathione derivative biosynthetic process (GO:1901687)6.93932232
10glutathione derivative metabolic process (GO:1901685)6.93932232
11regulation of centriole replication (GO:0046599)6.80297137
12striated muscle atrophy (GO:0014891)6.47563679
13sphingoid metabolic process (GO:0046519)6.42136549
14digestive system process (GO:0022600)6.40187112
15fibril organization (GO:0097435)6.35373606
16sulfation (GO:0051923)6.30006996
17protein autoprocessing (GO:0016540)5.99320215
18skeletal muscle adaptation (GO:0043501)5.72358999
19response to iron ion (GO:0010039)5.70583251
20negative regulation of organelle assembly (GO:1902116)5.63445475
21kidney morphogenesis (GO:0060993)5.54006941
22muscle atrophy (GO:0014889)5.52262613
23embryonic camera-type eye morphogenesis (GO:0048596)5.47092663
24diol metabolic process (GO:0034311)5.21578881
25response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.13740639
26purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.11682711
273-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.11682711
28glandular epithelial cell differentiation (GO:0002067)5.09537055
29cardiac right ventricle morphogenesis (GO:0003215)5.08277919
30regulation of proton transport (GO:0010155)4.92387614
31positive regulation of epidermal cell differentiation (GO:0045606)4.91193399
32protein O-linked glycosylation (GO:0006493)4.86677088
33vagina development (GO:0060068)4.86033106
34embryonic eye morphogenesis (GO:0048048)4.81210666
35desmosome organization (GO:0002934)4.78318696
36mesonephros development (GO:0001823)4.74198551
37cell proliferation involved in metanephros development (GO:0072203)4.69495970
38phospholipid scrambling (GO:0017121)4.66637779
39sphingosine metabolic process (GO:0006670)4.65634403
40regulation of establishment or maintenance of cell polarity (GO:0032878)4.55600218
41TOR signaling (GO:0031929)4.55381113
42regulation of establishment of cell polarity (GO:2000114)4.53385070
43one-carbon compound transport (GO:0019755)4.46492264
44intestinal epithelial cell development (GO:0060576)4.40308547
45production of molecular mediator of immune response (GO:0002440)4.40087043
46positive regulation of translational initiation (GO:0045948)4.28741561
47regulation of water loss via skin (GO:0033561)4.27026975
48intestinal absorption (GO:0050892)4.26502832
49ER overload response (GO:0006983)4.23906307
50ear development (GO:0043583)4.20457161
51regulation of keratinocyte differentiation (GO:0045616)4.19674327
52negative regulation of digestive system process (GO:0060457)4.17860613
53L-alpha-amino acid transmembrane transport (GO:1902475)4.17361709
54COPI coating of Golgi vesicle (GO:0048205)4.15145591
55Golgi transport vesicle coating (GO:0048200)4.15145591
56phosphatidylserine acyl-chain remodeling (GO:0036150)4.08665633
57negative regulation of kidney development (GO:0090185)4.08221241
58peptidyl-threonine dephosphorylation (GO:0035970)4.08134661
59regulation of phospholipase A2 activity (GO:0032429)4.07196435
60cellular zinc ion homeostasis (GO:0006882)4.03563140
61hypotonic response (GO:0006971)4.01414467
62norepinephrine metabolic process (GO:0042415)3.99627728
63sulfur amino acid catabolic process (GO:0000098)3.96171770
64L-fucose catabolic process (GO:0042355)3.95288941
65fucose catabolic process (GO:0019317)3.95288941
66L-fucose metabolic process (GO:0042354)3.95288941
67ventricular cardiac muscle cell action potential (GO:0086005)3.93274121
68regulation of histone H3-K27 methylation (GO:0061085)3.92250810
69branching involved in mammary gland duct morphogenesis (GO:0060444)3.86190242
70dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.84323232
71glutathione metabolic process (GO:0006749)3.79801820
72antibacterial humoral response (GO:0019731)3.76600199
73positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.70840187
74mesenchyme morphogenesis (GO:0072132)3.70643898
75regulation of skeletal muscle contraction (GO:0014819)3.70128206
76post-embryonic morphogenesis (GO:0009886)3.64519139
77thyroid hormone metabolic process (GO:0042403)3.64233739
78female genitalia development (GO:0030540)3.57079595
79regulation of glomerulus development (GO:0090192)3.53997794
80response to food (GO:0032094)3.53488353
81antimicrobial humoral response (GO:0019730)3.52330297
82maternal placenta development (GO:0001893)3.50014204
83phosphatidylserine metabolic process (GO:0006658)3.49500183
84phosphatidylinositol acyl-chain remodeling (GO:0036149)3.48608025
85regulation of centrosome duplication (GO:0010824)3.47512656
86cell proliferation involved in kidney development (GO:0072111)3.42168423
87peptidyl-arginine omega-N-methylation (GO:0035247)3.41666025
88cell communication involved in cardiac conduction (GO:0086065)3.40697654
89cyclooxygenase pathway (GO:0019371)3.38171711
90lung secretory cell differentiation (GO:0061140)3.37915276
91innate immune response in mucosa (GO:0002227)3.32881162
92positive regulation of Rho protein signal transduction (GO:0035025)3.31428028
93regulation of heart rate by cardiac conduction (GO:0086091)3.31097818
94insulin-like growth factor receptor signaling pathway (GO:0048009)3.31073223
95hemidesmosome assembly (GO:0031581)3.30230127
96cell differentiation involved in embryonic placenta development (GO:0060706)3.30226039
97zinc ion transmembrane transport (GO:0071577)3.29312667
98phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.29193440
99branching involved in salivary gland morphogenesis (GO:0060445)3.26730877
100ethanol metabolic process (GO:0006067)3.26323627
101epithelial cell-cell adhesion (GO:0090136)3.25663639
102negative regulation of cell size (GO:0045792)3.25172310
103positive regulation of epidermis development (GO:0045684)3.24374802
104xenobiotic catabolic process (GO:0042178)3.22607147
105embryonic skeletal joint morphogenesis (GO:0060272)3.20788801
106regulation of fatty acid beta-oxidation (GO:0031998)3.19461845
107negative regulation of focal adhesion assembly (GO:0051895)3.13906174
108negative regulation of cell junction assembly (GO:1901889)3.13906174
109negative regulation of adherens junction organization (GO:1903392)3.13906174
110xenobiotic metabolic process (GO:0006805)3.13560718
111positive regulation of peptidyl-threonine phosphorylation (GO:0010800)3.13044759
112viral mRNA export from host cell nucleus (GO:0046784)3.11936113
113phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.11721360
114primary alcohol catabolic process (GO:0034310)3.11101660
115negative regulation of Ras GTPase activity (GO:0034261)3.10560448
116negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.10378010
117COPII vesicle coating (GO:0048208)3.10098053
118epithelial cell maturation (GO:0002070)3.10043155
119negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.08041556
120face development (GO:0060324)3.07740194
121regulation of pH (GO:0006885)3.07709393
122positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.05037025
123sodium ion export (GO:0071436)3.03513761
124cardiac ventricle morphogenesis (GO:0003208)3.03388129
125amyloid precursor protein catabolic process (GO:0042987)3.02855736
126tight junction assembly (GO:0070830)3.01417247
127cellular response to arsenic-containing substance (GO:0071243)3.01408187
128thyroid hormone generation (GO:0006590)3.00540730
129acrosome reaction (GO:0007340)2.99580692
130cardiac conduction (GO:0061337)2.99375494
131flavonoid metabolic process (GO:0009812)2.98486790
132leukotriene metabolic process (GO:0006691)2.98278556
133regulation of apoptotic process involved in morphogenesis (GO:1902337)2.98110089
134regulation of mesenchymal cell apoptotic process (GO:2001053)2.96067193
135regulation of interleukin-13 production (GO:0032656)2.95946983
136establishment of skin barrier (GO:0061436)2.95908087
137cytoskeletal anchoring at plasma membrane (GO:0007016)2.95705147
138peptidyl-arginine methylation (GO:0018216)2.92524269
139peptidyl-arginine N-methylation (GO:0035246)2.92524269
140positive regulation of nitric-oxide synthase activity (GO:0051000)2.91089326
141embryonic foregut morphogenesis (GO:0048617)2.89861194
142regulation of cardioblast differentiation (GO:0051890)2.88478514
143negative regulation of embryonic development (GO:0045992)2.87139798
144positive regulation of insulin receptor signaling pathway (GO:0046628)2.86572303
145positive regulation of smooth muscle cell migration (GO:0014911)2.85481847
146embryonic retina morphogenesis in camera-type eye (GO:0060059)2.85384895
147endocrine hormone secretion (GO:0060986)2.84254357
148trophectodermal cell differentiation (GO:0001829)2.84237073
149positive regulation of response to extracellular stimulus (GO:0032106)2.84013396
150positive regulation of response to nutrient levels (GO:0032109)2.84013396
151positive regulation of macroautophagy (GO:0016239)2.83863988
152retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.82982543
153positive regulation of hormone metabolic process (GO:0032352)2.82817079
154positive regulation of skeletal muscle tissue development (GO:0048643)2.78302830
155hormone catabolic process (GO:0042447)2.77843829
156alditol phosphate metabolic process (GO:0052646)2.76526672
157regulation of ruffle assembly (GO:1900027)2.75293557
158regulation of centrosome cycle (GO:0046605)2.75109322
159biotin metabolic process (GO:0006768)2.74793061
160response to water (GO:0009415)2.74269054
161adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.73321948
162cellular response to estrogen stimulus (GO:0071391)2.71672771
163outflow tract septum morphogenesis (GO:0003148)2.71052133
164positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.68908695
165multicellular organismal water homeostasis (GO:0050891)2.68327088
166zinc ion homeostasis (GO:0055069)2.67793132
167positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.66903753
168regulation of transforming growth factor beta1 production (GO:0032908)2.65381139
169response to phenylpropanoid (GO:0080184)2.63471755
170nitric oxide biosynthetic process (GO:0006809)2.63315305
171acid secretion (GO:0046717)2.62540560
172mucosal immune response (GO:0002385)2.61689665
173detection of bacterium (GO:0016045)2.60636013
174cellular response to superoxide (GO:0071451)2.59869703
175cellular response to oxygen radical (GO:0071450)2.59869703
176removal of superoxide radicals (GO:0019430)2.59869703
177monovalent inorganic cation homeostasis (GO:0055067)2.59740051
178L-serine transport (GO:0015825)2.58583649
179potassium ion homeostasis (GO:0055075)2.57701517
180endocardial cushion development (GO:0003197)2.57516484
181intermediate filament organization (GO:0045109)2.56383289
182positive regulation of Cdc42 GTPase activity (GO:0043089)2.51678741
183epithelial cell differentiation involved in prostate gland development (GO:0060742)2.49835059
184columnar/cuboidal epithelial cell differentiation (GO:0002065)2.49572898
185cellular glucuronidation (GO:0052695)2.49264023
186arachidonic acid secretion (GO:0050482)2.48769633
187icosanoid secretion (GO:0032309)2.48769633
188protein localization to cell surface (GO:0034394)2.46124113
189regulation of transforming growth factor beta2 production (GO:0032909)2.46032365
190organ or tissue specific immune response (GO:0002251)2.44100339
191maintenance of gastrointestinal epithelium (GO:0030277)14.0078722
192epithelial structure maintenance (GO:0010669)11.1463082

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_15608294_ChIP-ChIP_MCF-7_Human4.48806465
2SOX2_27498859_Chip-Seq_STOMACH_Mouse4.46967986
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.29473072
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.94316146
5ESR1_21235772_ChIP-Seq_MCF-7_Human3.38666115
6ESR2_21235772_ChIP-Seq_MCF-7_Human3.22426188
7ER_23166858_ChIP-Seq_MCF-7_Human3.17733626
8STAT6_21828071_ChIP-Seq_BEAS2B_Human3.10908047
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.00615100
10TDRD3_21172665_ChIP-Seq_MCF-7_Human2.86233660
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.75928857
12PKCTHETA_26484144_Chip-Seq_BREAST_Human2.69335265
13SOX2_20726797_ChIP-Seq_SW620_Human2.58234811
14GATA4_25053715_ChIP-Seq_YYC3_Human2.49284754
15PPAR_26484153_Chip-Seq_NCI-H1993_Human2.47514152
16HIF1A_21447827_ChIP-Seq_MCF-7_Human2.46355570
17TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.37912388
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.24754609
19CDX2_20551321_ChIP-Seq_CACO-2_Human2.20606765
20PADI4_21655091_ChIP-ChIP_MCF-7_Human2.15765437
21ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.14729591
22TRIM28_21343339_ChIP-Seq_HEK293_Human2.12803641
23RARG_19884340_ChIP-ChIP_MEFs_Mouse2.04309356
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97065413
25AHR_22903824_ChIP-Seq_MCF-7_Human1.97012362
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.95679546
27GATA6_25053715_ChIP-Seq_YYC3_Human1.90379443
28ZNF217_24962896_ChIP-Seq_MCF-7_Human1.89433156
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.86189670
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75636145
31KLF5_25053715_ChIP-Seq_YYC3_Human1.72099380
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.68029809
33GATA3_24758297_ChIP-Seq_MCF-7_Human1.63444506
34FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.62218969
35SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.61022238
36SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.61022238
37P63_26484246_Chip-Seq_KERATINOCYTES_Human1.57673546
38KDM5A_27292631_Chip-Seq_BREAST_Human1.57387539
39PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.56091028
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53274281
41EP300_21415370_ChIP-Seq_HL-1_Mouse1.52440056
42ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.51902713
43ELF5_23300383_ChIP-Seq_T47D_Human1.51412016
44RUNX1_27514584_Chip-Seq_MCF-7_Human1.47630093
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46426528
46ARNT_22903824_ChIP-Seq_MCF-7_Human1.45987343
47CJUN_26792858_Chip-Seq_BT549_Human1.44424587
48FOXO3_23340844_ChIP-Seq_DLD1_Human1.42854569
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42457054
50ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.42128665
51KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39990937
52RACK7_27058665_Chip-Seq_MCF-7_Human1.39693446
53DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38002756
54AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.36614456
55ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.33086819
56BCAT_22108803_ChIP-Seq_LS180_Human1.32595221
57ZNF263_19887448_ChIP-Seq_K562_Human1.31845055
58KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31812908
59SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.31440724
60CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.31274827
61NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.29291930
62NRF2_20460467_ChIP-Seq_MEFs_Mouse1.29291930
63RXR_22108803_ChIP-Seq_LS180_Human1.29152061
64CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27261917
65FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27071574
66MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26320022
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.25441734
68PPARA_22158963_ChIP-Seq_LIVER_Mouse1.23860067
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23759496
70VDR_22108803_ChIP-Seq_LS180_Human1.21569958
71IGF1R_20145208_ChIP-Seq_DFB_Human1.20342994
72ZNF274_21170338_ChIP-Seq_K562_Hela1.19192972
73BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18760820
74HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18384246
75FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18097815
76FOXM1_23109430_ChIP-Seq_U2OS_Human1.16810099
77MYC_18555785_ChIP-Seq_MESCs_Mouse1.15455287
78RXR_22158963_ChIP-Seq_LIVER_Mouse1.14156237
79NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14094185
80LXR_22292898_ChIP-Seq_THP-1_Human1.14088492
81NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14058131
82JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13802577
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11637867
84JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11279920
85ATF3_27146783_Chip-Seq_COLON_Human1.10648142
86DCP1A_22483619_ChIP-Seq_HELA_Human1.10101857
87TCF4_18268006_ChIP-ChIP_LS174T_Human1.10085573
88* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07901140
89E2F7_22180533_ChIP-Seq_HELA_Human1.05624170
90LXR_22158963_ChIP-Seq_LIVER_Mouse1.03944698
91EGR1_19032775_ChIP-ChIP_M12_Human1.03371973
92CHD1_26751641_Chip-Seq_LNCaP_Human1.00103200
93STAT1_20625510_ChIP-Seq_HELA_Human0.99996050
94TP53_16413492_ChIP-PET_HCT116_Human0.99499878
95HOXB7_26014856_ChIP-Seq_BT474_Human0.99111062
96CLOCK_20551151_ChIP-Seq_293T_Human0.98842021
97TP53_18474530_ChIP-ChIP_U2OS_Human0.98575065
98BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.98124138
99ERG_21242973_ChIP-ChIP_JURKAT_Human0.98074737
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97079268
101PIAS1_25552417_ChIP-Seq_VCAP_Human0.96753378
102SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95423507
103KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.94981691
104KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.94981691
105KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.94981691
106FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.94530414
107FOXA2_19822575_ChIP-Seq_HepG2_Human0.94322150
108GATA1_22025678_ChIP-Seq_K562_Human0.94003640
109GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92888148
110TP63_23658742_ChIP-Seq_EP156T_Human0.92677741
111SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92131119
112NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91632042
113CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89454190
114MYCN_18555785_ChIP-Seq_MESCs_Mouse0.89201066
115ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89121832
116SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88968226
117RNF2_18974828_ChIP-Seq_MESCs_Mouse0.88908410
118EZH2_18974828_ChIP-Seq_MESCs_Mouse0.88908410
119CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88434247
120SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.87154230
121TFEB_21752829_ChIP-Seq_HELA_Human0.86984109
122HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86784655
123AR_21572438_ChIP-Seq_LNCaP_Human0.86563817
124MTF2_20144788_ChIP-Seq_MESCs_Mouse0.85627150
125EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.85557418
126FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.85515997
127NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85204029
128CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.84967446
129TP63_22573176_ChIP-Seq_HFKS_Human0.83677792
130CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83433848
131MYC_19079543_ChIP-ChIP_MESCs_Mouse0.83227094
132PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83127345
133SRY_22984422_ChIP-ChIP_TESTIS_Rat0.81366444
134FOXA1_25552417_ChIP-Seq_VCAP_Human0.81017835
135XRN2_22483619_ChIP-Seq_HELA_Human0.79558618
136ZFP281_18757296_ChIP-ChIP_E14_Mouse0.79485064
137KDM2B_26808549_Chip-Seq_K562_Human0.78763290
138SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.78195085
139POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.78075404
140JARID2_20075857_ChIP-Seq_MESCs_Mouse0.77600423
141TCF7_22412390_ChIP-Seq_EML_Mouse0.76756966
142TCF4_22108803_ChIP-Seq_LS180_Human0.76063387
143TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75770913
144Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.75679606
145RAD21_21589869_ChIP-Seq_MESCs_Mouse0.75431864
146AR_21909140_ChIP-Seq_LNCAP_Human0.74276815
147MYC_19030024_ChIP-ChIP_MESCs_Mouse0.73907545
148TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73283680
149SALL1_21062744_ChIP-ChIP_HESCs_Human0.73172648
150CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.72410217
151TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.72330826
152STAT3_1855785_ChIP-Seq_MESCs_Mouse0.72053946
153KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.71403556
154GABP_19822575_ChIP-Seq_HepG2_Human0.70888528
155TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.68262348
156GATA3_21867929_ChIP-Seq_CD8_Mouse0.68120360
157NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.67103210
158PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.65284799
159JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.65230286
160ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.64283675
161FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.62280765

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001873_stomach_inflammation5.34438496
2MP0001664_abnormal_digestion4.95283828
3MP0010386_abnormal_urinary_bladder3.71408085
4MP0000470_abnormal_stomach_morphology3.44880442
5MP0010234_abnormal_vibrissa_follicle3.28771427
6MP0005076_abnormal_cell_differentiation3.17610266
7MP0004233_abnormal_muscle_weight2.96695540
8MP0000516_abnormal_urinary_system2.87654522
9MP0005367_renal/urinary_system_phenotyp2.87654522
10MP0003123_paternal_imprinting2.73127318
11MP0000427_abnormal_hair_cycle2.62889999
12MP0003806_abnormal_nucleotide_metabolis2.62337018
13MP0004381_abnormal_hair_follicle2.55379560
14MP0002877_abnormal_melanocyte_morpholog2.45759787
15MP0005423_abnormal_somatic_nervous2.20194020
16MP0006054_spinal_hemorrhage2.15676313
17MP0004264_abnormal_extraembryonic_tissu2.07333157
18MP0001663_abnormal_digestive_system2.05567153
19MP0000537_abnormal_urethra_morphology2.04375916
20MP0008004_abnormal_stomach_pH14.9232010
21MP0005381_digestive/alimentary_phenotyp1.93403248
22MP0005075_abnormal_melanosome_morpholog1.88398910
23MP0000627_abnormal_mammary_gland1.74474101
24MP0003787_abnormal_imprinting1.72506849
25MP0002009_preneoplasia1.57460532
26MP0005646_abnormal_pituitary_gland1.53702168
27MP0002796_impaired_skin_barrier1.53327346
28MP0009672_abnormal_birth_weight1.52534317
29MP0001727_abnormal_embryo_implantation1.50688071
30MP0000462_abnormal_digestive_system1.50321959
31MP0001666_abnormal_nutrient_absorption1.46724371
32MP0001944_abnormal_pancreas_morphology1.45850337
33MP0005275_abnormal_skin_tensile1.43698311
34MP0003705_abnormal_hypodermis_morpholog1.40263141
35MP0003283_abnormal_digestive_organ1.38978984
36MP0005409_darkened_coat_color1.38670698
37MP0002249_abnormal_larynx_morphology1.37980953
38MP0005165_increased_susceptibility_to1.35763678
39MP0003880_abnormal_central_pattern1.30675218
40MP0003942_abnormal_urinary_system1.28958380
41MP0000477_abnormal_intestine_morphology1.26313222
42MP0002693_abnormal_pancreas_physiology1.25649743
43MP0002751_abnormal_autonomic_nervous1.25426989
44MP0003936_abnormal_reproductive_system1.23369129
45MP0002234_abnormal_pharynx_morphology1.22732424
46MP0003693_abnormal_embryo_hatching1.21603905
47MP0001881_abnormal_mammary_gland1.21358843
48MP0008057_abnormal_DNA_replication1.17283946
49MP0004270_analgesia1.14996619
50MP0009703_decreased_birth_body1.12987230
51MP0004782_abnormal_surfactant_physiolog1.12693317
52MP0001348_abnormal_lacrimal_gland1.11777662
53MP0009384_cardiac_valve_regurgitation1.10391590
54MP0002060_abnormal_skin_morphology1.07635554
55MP0000467_abnormal_esophagus_morphology1.02703242
56MP0005083_abnormal_biliary_tract1.01679513
57MP0003453_abnormal_keratinocyte_physiol1.00360544
58MP0000371_diluted_coat_color1.00025987
59MP0003941_abnormal_skin_development0.95912064
60MP0002160_abnormal_reproductive_system0.95064213
61MP0002184_abnormal_innervation0.94582613
62MP0001186_pigmentation_phenotype0.93146488
63MP0003183_abnormal_peptide_metabolism0.92934299
64MP0002909_abnormal_adrenal_gland0.91861232
65MP0008872_abnormal_physiological_respon0.90805545
66MP0002089_abnormal_postnatal_growth/wei0.90730900
67MP0000534_abnormal_ureter_morphology0.90575703
68MP0001919_abnormal_reproductive_system0.88171398
69MP0010678_abnormal_skin_adnexa0.88109361
70MP0005451_abnormal_body_composition0.86245087
71MP0005085_abnormal_gallbladder_physiolo0.85827415
72MP0003011_delayed_dark_adaptation0.85710109
73MP0005058_abnormal_lysosome_morphology0.85324747
74MP0005501_abnormal_skin_physiology0.85231764
75MP0004957_abnormal_blastocyst_morpholog0.83971966
76MP0000538_abnormal_urinary_bladder0.83873176
77MP0000750_abnormal_muscle_regeneration0.83764090
78MP0001340_abnormal_eyelid_morphology0.78734830
79MP0005220_abnormal_exocrine_pancreas0.76235758
80MP0003186_abnormal_redox_activity0.75997227
81MP0004185_abnormal_adipocyte_glucose0.75683077
82MP0001697_abnormal_embryo_size0.75546919
83MP0003315_abnormal_perineum_morphology0.74844889
84MP0000579_abnormal_nail_morphology0.73927894
85MP0004197_abnormal_fetal_growth/weight/0.73763170
86MP0001216_abnormal_epidermal_layer0.73673619
87MP0008875_abnormal_xenobiotic_pharmacok0.73507696
88MP0005379_endocrine/exocrine_gland_phen0.73286758
89MP0001243_abnormal_dermal_layer0.72814844
90MP0010307_abnormal_tumor_latency0.72388908
91MP0002075_abnormal_coat/hair_pigmentati0.71340560
92MP0005636_abnormal_mineral_homeostasis0.70760200
93MP0003566_abnormal_cell_adhesion0.70481230
94MP0010155_abnormal_intestine_physiology0.70283664
95MP0002098_abnormal_vibrissa_morphology0.69432710
96MP0004484_altered_response_of0.69419851
97MP0010771_integument_phenotype0.69265163
98MP0003866_abnormal_defecation0.65590212
99MP0001529_abnormal_vocalization0.65575209
100MP0000013_abnormal_adipose_tissue0.61699256
101MP0003638_abnormal_response/metabolism_0.61256992
102MP0004947_skin_inflammation0.59548531
103MP0002332_abnormal_exercise_endurance0.59222484
104MP0003953_abnormal_hormone_level0.59070074
105MP0004858_abnormal_nervous_system0.59069262
106MP0001756_abnormal_urination0.58963608
107MP0001765_abnormal_ion_homeostasis0.57553225
108MP0002088_abnormal_embryonic_growth/wei0.57502326
109MP0002078_abnormal_glucose_homeostasis0.57165410
110MP0003329_amyloid_beta_deposits0.56921682
111MP0000377_abnormal_hair_follicle0.55678331
112MP0002254_reproductive_system_inflammat0.55234650
113MP0000490_abnormal_crypts_of0.55090152
114MP0004036_abnormal_muscle_relaxation0.54708123
115MP0005365_abnormal_bile_salt0.54170095
116MP0002822_catalepsy0.53544602
117MP0000762_abnormal_tongue_morphology0.51835667
118MP0004145_abnormal_muscle_electrophysio0.49290775
119MP0005503_abnormal_tendon_morphology0.49019490
120MP0000613_abnormal_salivary_gland0.46677401
121MP0000647_abnormal_sebaceous_gland0.45979997
122MP0004147_increased_porphyrin_level0.44688971
123MP0001849_ear_inflammation0.44398644
124MP0005408_hypopigmentation0.42494856
125MP0003868_abnormal_feces_composition0.40606762
126MP0005266_abnormal_metabolism0.40244577
127MP0002837_dystrophic_cardiac_calcinosis0.39700766
128MP0009053_abnormal_anal_canal0.38394834
129MP0002166_altered_tumor_susceptibility0.37243733
130MP0005248_abnormal_Harderian_gland0.37241922
131MP0003191_abnormal_cellular_cholesterol0.36478527
132MP0010329_abnormal_lipoprotein_level0.36307043
133MP0003075_altered_response_to0.36107649
134MP0003656_abnormal_erythrocyte_physiolo0.35457163
135MP0005166_decreased_susceptibility_to0.34818450
136MP0000465_gastrointestinal_hemorrhage0.30785053
137MP0008438_abnormal_cutaneous_collagen0.30221246
138MP0000367_abnormal_coat/_hair0.30185654
139MP0001958_emphysema0.29747691
140MP0000751_myopathy0.29384037
141MP0010352_gastrointestinal_tract_polyps0.28534726
142MP0009780_abnormal_chondrocyte_physiolo0.28186757
143MP0009931_abnormal_skin_appearance0.27134165
144MP0003119_abnormal_digestive_system0.26916599
145MP0001191_abnormal_skin_condition0.26057517
146MP0002006_tumorigenesis0.25845461
147MP0000003_abnormal_adipose_tissue0.25262470
148MP0008873_increased_physiological_sensi0.24920826
149MP0004272_abnormal_basement_membrane0.24100080
150MP0000383_abnormal_hair_follicle0.23933101
151MP0003252_abnormal_bile_duct0.23892344
152MP0009643_abnormal_urine_homeostasis0.23500029
153MP0005620_abnormal_muscle_contractility0.23498182

Predicted human phenotypes

RankGene SetZ-score
1J-shaped sella turcica (HP:0002680)9.43558041
2Right ventricular cardiomyopathy (HP:0011663)9.00729006
3Absent frontal sinuses (HP:0002688)6.63910161
4Asymmetry of the thorax (HP:0001555)6.61997881
5Microglossia (HP:0000171)6.60487521
6Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)5.32447265
7Breast carcinoma (HP:0003002)5.15761736
8Septate vagina (HP:0001153)5.05302653
9Deformed sella turcica (HP:0002681)4.95404035
10Chromosomal breakage induced by crosslinking agents (HP:0003221)4.85712272
11Aortic aneurysm (HP:0004942)4.84901978
12Abnormal number of erythroid precursors (HP:0012131)4.74375292
13Abnormality of the frontal sinuses (HP:0002687)4.64178219
14Woolly hair (HP:0002224)4.56562447
15Aortic dissection (HP:0002647)4.53421422
16Abnormality of cells of the erythroid lineage (HP:0012130)4.43266539
17Aplasia/Hypoplasia involving the sinuses (HP:0009120)4.40338117
18Chromsome breakage (HP:0040012)4.38761656
19Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.12482112
20Concave nail (HP:0001598)4.03493733
21Malnutrition (HP:0004395)3.89171077
22Thyroid carcinoma (HP:0002890)3.62481424
23Papillary thyroid carcinoma (HP:0002895)3.62010518
24Cutaneous melanoma (HP:0012056)3.59973188
25Ventricular fibrillation (HP:0001663)3.56734139
26Enlarged penis (HP:0000040)3.50158429
27Abnormality of the sella turcica (HP:0002679)3.41289437
28Abnormality of the 2nd finger (HP:0004100)3.37686705
29Palpitations (HP:0001962)3.29226565
30Syncope (HP:0001279)3.25650283
31Germ cell neoplasia (HP:0100728)3.22570049
32Macroorchidism (HP:0000053)3.20048577
33Esophageal varix (HP:0002040)3.10879934
34Gastrointestinal dysmotility (HP:0002579)3.08073872
35Gout (HP:0001997)2.99666149
36Hypopigmentation of the fundus (HP:0007894)2.97437814
37High pitched voice (HP:0001620)2.94543179
38Buphthalmos (HP:0000557)2.87131231
39Short hallux (HP:0010109)2.82620618
40Ankle contracture (HP:0006466)2.79497912
41Pustule (HP:0200039)2.78336482
42Abnormality of the 1st metacarpal (HP:0010009)2.77598365
43Arterial tortuosity (HP:0005116)2.76083508
44Hypercortisolism (HP:0001578)2.73326564
45Back pain (HP:0003418)2.70710497
46Abnormality of the vitamin B12 metabolism (HP:0004341)2.69449044
47Nephroblastoma (Wilms tumor) (HP:0002667)2.69285650
48Milia (HP:0001056)2.68747140
49Fragile nails (HP:0001808)2.67545849
50Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.67319233
51Goiter (HP:0000853)2.63553190
52Menstrual irregularities (HP:0000858)2.63062460
53Ventricular tachycardia (HP:0004756)2.62090049
54Neoplasm of the heart (HP:0100544)2.58361724
55Pili torti (HP:0003777)2.53207356
56Testicular atrophy (HP:0000029)2.52117439
57Aplasia/Hypoplasia of the hallux (HP:0008362)2.52027728
58Atrophic scars (HP:0001075)2.51888732
59Onycholysis (HP:0001806)2.51811096
60Plantar hyperkeratosis (HP:0007556)2.50946448
61Abnormality of vitamin B metabolism (HP:0004340)2.49006828
62Mesomelia (HP:0003027)2.48588218
63Abnormality of calcium-phosphate metabolism (HP:0100530)2.47336154
64Embryonal renal neoplasm (HP:0011794)2.46773926
65Vascular tortuosity (HP:0004948)2.45559207
66Neoplasm of the thyroid gland (HP:0100031)2.45543181
67Growth hormone excess (HP:0000845)2.40624256
68Scapular winging (HP:0003691)2.38337872
69Abnormality of the middle phalanges of the toes (HP:0010183)2.37934899
70Ventricular arrhythmia (HP:0004308)2.36555887
71Abnormality of vitamin metabolism (HP:0100508)2.35627377
72Type 1 muscle fiber predominance (HP:0003803)2.35569609
73Radial bowing (HP:0002986)2.35435580
74Spinal cord lesions (HP:0100561)2.35269972
75Syringomyelia (HP:0003396)2.35269972
76Frequent falls (HP:0002359)2.34733900
77Symphalangism affecting the phalanges of the hand (HP:0009773)2.34076830
78Deep philtrum (HP:0002002)2.33996298
79Increased variability in muscle fiber diameter (HP:0003557)2.32264450
80Aortic regurgitation (HP:0001659)2.31375444
81Abnormal foot bone ossification (HP:0010675)2.29601760
82Abnormality of the preputium (HP:0100587)2.28717152
83Pheochromocytoma (HP:0002666)2.28360687
84Flat acetabular roof (HP:0003180)2.25000922
85Bundle branch block (HP:0011710)2.22462393
86Amelogenesis imperfecta (HP:0000705)2.21401926
87Vascular calcification (HP:0004934)2.19828039
88Termporal pattern (HP:0011008)2.18931433
89Insidious onset (HP:0003587)2.18931433
90Prostate neoplasm (HP:0100787)2.16660805
91Hyperphosphatemia (HP:0002905)2.14416020
92Meckel diverticulum (HP:0002245)2.14329793
93Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.13773787
94Short 1st metacarpal (HP:0010034)2.13773787
95Abnormality of the gastric mucosa (HP:0004295)2.13104889
96Curly hair (HP:0002212)2.11968636
97Abnormality of skeletal muscle fiber size (HP:0012084)2.11603842
98Stridor (HP:0010307)2.11470533
99Tarsal synostosis (HP:0008368)2.09166029
100Cerebral aneurysm (HP:0004944)2.08294750
101Aneurysm (HP:0002617)2.06568019
102Hoarse voice (HP:0001609)2.06540233
103Intrahepatic cholestasis (HP:0001406)2.06355826
104Fibular aplasia (HP:0002990)2.05909276
105Abnormal tarsal ossification (HP:0008369)2.03191687
106Abnormality of purine metabolism (HP:0004352)2.02904328
107Abnormality of oral frenula (HP:0000190)2.01176952
108Hyperacusis (HP:0010780)2.00962108
109Cardiovascular calcification (HP:0011915)2.00512789
110Mildly elevated creatine phosphokinase (HP:0008180)1.99398210
111Glomerulosclerosis (HP:0000096)1.98251307
112Congenital glaucoma (HP:0001087)1.98144897
113Meningioma (HP:0002858)1.97199870
114Abnormality of the ileum (HP:0001549)1.96906046
115Abnormality of the carotid arteries (HP:0005344)1.94833048
116Bowed forearm bones (HP:0003956)1.94524114
117Bowing of the arm (HP:0006488)1.94524114
118Aplasia/Hypoplasia of the uvula (HP:0010293)1.94056001
119Micronodular cirrhosis (HP:0001413)1.93938663
120Hyperparathyroidism (HP:0000843)1.92914870
121Hypokinesia (HP:0002375)1.92673158
122Abnormality of chromosome stability (HP:0003220)1.91432475
123Abnormality of the proximal phalanges of the hand (HP:0009834)1.90241167
124Conjunctival hamartoma (HP:0100780)1.89260630
125Abnormality of the umbilical cord (HP:0010881)1.88765790
126Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.88060561
127Abnormality of the distal phalanx of the thumb (HP:0009617)1.87861435
128Hyperuricemia (HP:0002149)1.86707075
129Increased purine levels (HP:0004368)1.86707075
130Neuroendocrine neoplasm (HP:0100634)1.86512867
131Testicular neoplasm (HP:0010788)1.86180636
132Long toe (HP:0010511)1.85853513
133Hypotrichosis (HP:0001006)1.85689015
134Thin bony cortex (HP:0002753)1.84688136
135Microretrognathia (HP:0000308)1.83626143
136Facial diplegia (HP:0001349)1.83371092
137Abnormality of aromatic amino acid family metabolism (HP:0004338)1.83179996
138Sparse lateral eyebrow (HP:0005338)1.81938488
139Synostosis involving bones of the lower limbs (HP:0009138)1.80507605
140Synostosis involving bones of the feet (HP:0009140)1.80507605
141Deformed tarsal bones (HP:0008119)1.80150077
142Spastic diplegia (HP:0001264)1.79972903
143Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.79972592
144Dilatation of the ascending aorta (HP:0005111)1.77915249
145Short humerus (HP:0005792)1.77710385
146Reticulocytosis (HP:0001923)1.77692568
147Short phalanx of the thumb (HP:0009660)1.74638239
148Palmoplantar hyperkeratosis (HP:0000972)1.74613542
149Progressive muscle weakness (HP:0003323)1.73462044
150Agitation (HP:0000713)1.73238301
151Hyperthyroidism (HP:0000836)1.72794717
152Megaloblastic anemia (HP:0001889)1.72646967
153Abnormal cartilage morphology (HP:0002763)1.72543283
154Synostosis involving the elbow (HP:0003938)1.72371625
155Humeroradial synostosis (HP:0003041)1.72371625
156Trismus (HP:0000211)1.72117535
157Fragile skin (HP:0001030)1.71820057
158Uterine leiomyosarcoma (HP:0002891)1.71518681
159Leiomyosarcoma (HP:0100243)1.71518681
160Abdominal distention (HP:0003270)1.70850319
161Focal segmental glomerulosclerosis (HP:0000097)1.69687312
162Aplasia/Hypoplasia of the tongue (HP:0010295)1.68338038
163Rectal prolapse (HP:0002035)1.68205091
164Wrist flexion contracture (HP:0001239)1.67811438
165Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.67592271
166Short thumb (HP:0009778)1.67196364
167Ulnar bowing (HP:0003031)1.67034164
168Hypoparathyroidism (HP:0000829)1.67002892
169Mucopolysacchariduria (HP:0008155)1.66490419
170Urinary glycosaminoglycan excretion (HP:0003541)1.66490419
171Abnormal ossification of hand bones (HP:0005921)1.66117095
172Cupped ribs (HP:0000887)1.65413767
173Embryonal neoplasm (HP:0002898)1.64495169
174Melanoma (HP:0002861)1.64225267
175Spinal cord compression (HP:0002176)1.63570204
176Abnormality of nail color (HP:0100643)1.63546982
177Transitional cell carcinoma of the bladder (HP:0006740)1.62913053
178Advanced eruption of teeth (HP:0006288)1.62585494
179Lymphangioma (HP:0100764)1.61764050
180Tongue fasciculations (HP:0001308)1.61609546
181Broad face (HP:0000283)1.61483191
182Uterine neoplasm (HP:0010784)1.57716244
183Hamartoma of the eye (HP:0010568)1.56572409
184Restlessness (HP:0000711)1.56261995
185Exostoses (HP:0100777)1.56235576
186Congenital malformation of the right heart (HP:0011723)1.54050594
187Double outlet right ventricle (HP:0001719)1.54050594
188Arteriovenous malformation (HP:0100026)1.53904313
189Cystic hygroma (HP:0000476)1.52325191

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SCYL26.15820754
2MST1R4.29384673
3SIK14.04308203
4MST43.54610697
5NEK63.48597913
6MYLK3.04502340
7MUSK3.03171335
8TTN3.00041056
9MAP3K22.45142653
10FER2.39996569
11PKN22.21100180
12EIF2AK12.13880453
13SMG12.10344058
14LMTK22.05544338
15LATS12.01148389
16ERBB410.2474872
17KSR21.76014298
18MAP3K91.74312960
19RIPK41.72852378
20FRK1.66226983
21NME21.66058686
22PIK3CG1.62768591
23CHUK1.56173450
24MET1.52916860
25TRIM281.51586782
26TNK21.43583066
27TESK11.42192691
28TRIB31.41946992
29SIK31.38538120
30RPS6KB11.34243661
31EPHA21.32140923
32LRRK21.30271262
33NUAK11.23624682
34FGFR41.23479441
35FGFR21.20919645
36DDR21.20458295
37DMPK1.17346869
38PTK61.14746072
39MAP2K11.12517467
40PIK3CA1.11129353
41SRPK11.10597582
42TAF11.07418197
43LATS21.04268083
44EPHB21.04250326
45EIF2AK21.03467971
46RIPK11.03259861
47PAK31.01056873
48IRAK30.93883696
49MAP2K20.91683170
50LIMK10.91155554
51ERN10.90065682
52VRK20.88195814
53MAP3K30.86564683
54EEF2K0.85223621
55PRKG20.85047236
56CSF1R0.83820751
57GRK60.78594582
58PRKCI0.76028369
59RPS6KB20.75166814
60FYN0.73928188
61RPS6KA40.72506973
62MTOR0.71415743
63MINK10.70344326
64STK390.70148358
65PDGFRB0.70124906
66IKBKB0.68857403
67CAMK2G0.68580302
68CDK70.67309343
69PDK30.67074382
70PDK40.67074382
71ARAF0.66396355
72ROCK20.64558430
73PTK20.64140020
74MAPKAPK30.63702209
75BRD40.62861475
76STK100.61455686
77RPS6KA20.60599053
78PAK20.60299674
79ERBB20.60257833
80BCR0.57707141
81PDK20.56213578
82TAOK10.54293626
83DAPK10.53560997
84PHKG10.51718589
85PHKG20.51718589
86TRPM70.51301619
87FGFR30.51257455
88RAF10.51230489
89NEK10.50230129
90SRC0.49373751
91ROCK10.48477377
92PAK40.45485471
93MAPKAPK20.45055614
94RET0.44850141
95CAMK2B0.43462736
96WNK40.41948556
97TBK10.40731791
98STK38L0.39909898
99PDPK10.39824696
100MAP3K10.38983191
101TESK20.38743047
102TSSK60.36648153
103PDGFRA0.36442310
104BMX0.36245294
105MAP3K120.36004975
106CAMK2D0.35927302
107NME10.35216639
108PRKCZ0.35180625
109CSNK1D0.34857368
110EIF2AK30.34053580
111KSR10.33148940
112MAP2K40.32494638
113NTRK10.31707032
114CDK190.31356080
115GRK10.30456819
116PAK10.30182567
117PDK10.29721552
118OXSR10.29645970
119MAPKAPK50.29119427
120EPHB10.26955557
121EPHA40.26841678
122MAP3K80.26815803
123HIPK20.26604555
124PRKCE0.25304129
125JAK10.25147907
126CDC42BPA0.25089357
127BMPR20.24842877
128CLK10.22930938
129MELK0.22854647
130IKBKE0.22790203
131CDK80.22255448
132CAMKK10.22219754
133STK380.21900170
134ERBB30.21789946
135CASK0.21720169
136STK30.21487876
137RPS6KA10.21440188
138CDK50.21409087
139YES10.21381651
140MAPK80.21093751
141PBK0.21002635
142FGFR10.20881370
143DAPK30.20839505
144BCKDK0.19672156
145AURKB0.19550389
146MAP2K60.19480543
147ILK0.19217062
148MAPK90.18096570
149FLT30.17920769
150PRKD30.16626720
151AKT20.15583413
152ICK0.15320217
153CSNK1E0.15129533
154ALK0.14473585
155CDK60.14015165

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.74672382
2Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.26795539
3Sulfur metabolism_Homo sapiens_hsa009204.20292053
4Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.95752697
5Gastric acid secretion_Homo sapiens_hsa049713.92349352
6Chemical carcinogenesis_Homo sapiens_hsa052043.54582548
7Collecting duct acid secretion_Homo sapiens_hsa049663.15924547
8Glutathione metabolism_Homo sapiens_hsa004802.89577276
9Vitamin B6 metabolism_Homo sapiens_hsa007502.57119324
10mTOR signaling pathway_Homo sapiens_hsa041502.48151498
11Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.46240275
12Acute myeloid leukemia_Homo sapiens_hsa052212.22234087
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.10363332
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.07913261
15Thyroid hormone signaling pathway_Homo sapiens_hsa049192.04369420
16Longevity regulating pathway - mammal_Homo sapiens_hsa042112.02251276
17Fat digestion and absorption_Homo sapiens_hsa049751.94931546
18Linoleic acid metabolism_Homo sapiens_hsa005911.87693879
19Mineral absorption_Homo sapiens_hsa049781.87256311
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.71726739
21AMPK signaling pathway_Homo sapiens_hsa041521.70541201
22Non-small cell lung cancer_Homo sapiens_hsa052231.70007967
23Inositol phosphate metabolism_Homo sapiens_hsa005621.68553751
24Central carbon metabolism in cancer_Homo sapiens_hsa052301.66973058
25Insulin signaling pathway_Homo sapiens_hsa049101.65161994
26Glioma_Homo sapiens_hsa052141.55845090
27Proteasome_Homo sapiens_hsa030501.53938817
28Renal cell carcinoma_Homo sapiens_hsa052111.47869466
29Hepatitis C_Homo sapiens_hsa051601.46636816
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.45581640
31Ether lipid metabolism_Homo sapiens_hsa005651.44897114
32TGF-beta signaling pathway_Homo sapiens_hsa043501.42501182
33Insulin resistance_Homo sapiens_hsa049311.41470518
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.41040842
35Pancreatic secretion_Homo sapiens_hsa049721.37786575
36Choline metabolism in cancer_Homo sapiens_hsa052311.37249281
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.35928881
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.31745761
39Sphingolipid metabolism_Homo sapiens_hsa006001.31157420
40Phenylalanine metabolism_Homo sapiens_hsa003601.26933677
41Selenocompound metabolism_Homo sapiens_hsa004501.25662548
42N-Glycan biosynthesis_Homo sapiens_hsa005101.25413280
43Vascular smooth muscle contraction_Homo sapiens_hsa042701.21665690
44Tight junction_Homo sapiens_hsa045301.17980036
45Steroid biosynthesis_Homo sapiens_hsa001001.17662517
46Melanoma_Homo sapiens_hsa052181.15503860
47Histidine metabolism_Homo sapiens_hsa003401.14353908
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.13903634
49Chronic myeloid leukemia_Homo sapiens_hsa052201.10428751
50Vitamin digestion and absorption_Homo sapiens_hsa049771.08406208
51Bladder cancer_Homo sapiens_hsa052191.08090571
52Folate biosynthesis_Homo sapiens_hsa007901.01498975
53Bile secretion_Homo sapiens_hsa049761.00253871
54Retinol metabolism_Homo sapiens_hsa008300.99710494
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96989785
56RNA transport_Homo sapiens_hsa030130.96754659
57Prolactin signaling pathway_Homo sapiens_hsa049170.96372312
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95071016
59Fatty acid degradation_Homo sapiens_hsa000710.93964550
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92733058
61Prostate cancer_Homo sapiens_hsa052150.92192215
62Glucagon signaling pathway_Homo sapiens_hsa049220.92191063
63Thyroid cancer_Homo sapiens_hsa052160.91828602
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91014478
65Thyroid hormone synthesis_Homo sapiens_hsa049180.89993733
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88934835
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.84738611
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81865247
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81841928
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81458681
71beta-Alanine metabolism_Homo sapiens_hsa004100.78383517
72Type II diabetes mellitus_Homo sapiens_hsa049300.76214991
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.75862733
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75640377
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75005352
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73946989
77Adherens junction_Homo sapiens_hsa045200.73005625
78Nitrogen metabolism_Homo sapiens_hsa009100.72427430
79Synaptic vesicle cycle_Homo sapiens_hsa047210.72306217
80Fanconi anemia pathway_Homo sapiens_hsa034600.71739600
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71332551
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70613188
83Pyruvate metabolism_Homo sapiens_hsa006200.67847457
84Vibrio cholerae infection_Homo sapiens_hsa051100.65755295
85Ovarian steroidogenesis_Homo sapiens_hsa049130.63956808
86Arachidonic acid metabolism_Homo sapiens_hsa005900.62789598
87Salivary secretion_Homo sapiens_hsa049700.62717754
88Propanoate metabolism_Homo sapiens_hsa006400.62522877
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62399143
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.61713576
91HIF-1 signaling pathway_Homo sapiens_hsa040660.60462040
92Glycerolipid metabolism_Homo sapiens_hsa005610.59189355
93Butanoate metabolism_Homo sapiens_hsa006500.58620564
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.56253413
95mRNA surveillance pathway_Homo sapiens_hsa030150.56123607
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55392259
97Dorso-ventral axis formation_Homo sapiens_hsa043200.55118444
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54031339
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53020555
100Tyrosine metabolism_Homo sapiens_hsa003500.52588183
101Endocytosis_Homo sapiens_hsa041440.52441778
102Oxidative phosphorylation_Homo sapiens_hsa001900.52424808
103ECM-receptor interaction_Homo sapiens_hsa045120.52368326
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51090603
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50483226
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.49846313
107GnRH signaling pathway_Homo sapiens_hsa049120.49805073
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.49609641
109PPAR signaling pathway_Homo sapiens_hsa033200.49498026
110Sulfur relay system_Homo sapiens_hsa041220.49474241
111Focal adhesion_Homo sapiens_hsa045100.47319285
112Proteoglycans in cancer_Homo sapiens_hsa052050.47099299
113FoxO signaling pathway_Homo sapiens_hsa040680.46540976
114Fatty acid elongation_Homo sapiens_hsa000620.45161200
115Fructose and mannose metabolism_Homo sapiens_hsa000510.44660094
116Carbon metabolism_Homo sapiens_hsa012000.44569930
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.44335728
118Hippo signaling pathway_Homo sapiens_hsa043900.43750148
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.43384352
120Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42845965
121Spliceosome_Homo sapiens_hsa030400.42182409
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41998772
123Pancreatic cancer_Homo sapiens_hsa052120.41497731
124Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40760290
125MicroRNAs in cancer_Homo sapiens_hsa052060.40667692
126Long-term potentiation_Homo sapiens_hsa047200.38585034
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38388549
128Hepatitis B_Homo sapiens_hsa051610.37304216
129Amphetamine addiction_Homo sapiens_hsa050310.36731509
130Lysosome_Homo sapiens_hsa041420.36574453
131Melanogenesis_Homo sapiens_hsa049160.35001250
132Starch and sucrose metabolism_Homo sapiens_hsa005000.33596506
133Salmonella infection_Homo sapiens_hsa051320.33093081
134Cardiac muscle contraction_Homo sapiens_hsa042600.32632099
135Estrogen signaling pathway_Homo sapiens_hsa049150.32448849
136Insulin secretion_Homo sapiens_hsa049110.32229700
137Colorectal cancer_Homo sapiens_hsa052100.32054730
138Renin secretion_Homo sapiens_hsa049240.31564025
139Fatty acid metabolism_Homo sapiens_hsa012120.31215400
140Pentose phosphate pathway_Homo sapiens_hsa000300.30851666
141Oxytocin signaling pathway_Homo sapiens_hsa049210.29358465
142Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28285878
143Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28204280
144Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.27659432
145Endometrial cancer_Homo sapiens_hsa052130.27044007
146Alzheimers disease_Homo sapiens_hsa050100.26992830
147VEGF signaling pathway_Homo sapiens_hsa043700.26179745
148Axon guidance_Homo sapiens_hsa043600.25559336
149Dilated cardiomyopathy_Homo sapiens_hsa054140.25124444
150Arginine biosynthesis_Homo sapiens_hsa002200.24964689
151Long-term depression_Homo sapiens_hsa047300.24706534
152Gap junction_Homo sapiens_hsa045400.24210860
153Platelet activation_Homo sapiens_hsa046110.22911997
154Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20931706
155Shigellosis_Homo sapiens_hsa051310.20325675
156Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.20249736
157ErbB signaling pathway_Homo sapiens_hsa040120.20051217
158Amoebiasis_Homo sapiens_hsa051460.19777337
159Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.19487597

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