

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.18806159 |
| 2 | interferon-gamma production (GO:0032609) | 4.03633574 |
| 3 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 4.03002882 |
| 4 | positive regulation of gamma-delta T cell activation (GO:0046645) | 3.93098824 |
| 5 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 3.61063321 |
| 6 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 3.61063321 |
| 7 | antigen processing and presentation of endogenous antigen (GO:0019883) | 3.54233254 |
| 8 | ER overload response (GO:0006983) | 3.48275130 |
| 9 | hepatocyte apoptotic process (GO:0097284) | 3.36102136 |
| 10 | COPII vesicle coating (GO:0048208) | 3.33195305 |
| 11 | regulation of gamma-delta T cell activation (GO:0046643) | 3.32306672 |
| 12 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.30251569 |
| 13 | NIK/NF-kappaB signaling (GO:0038061) | 3.26957276 |
| 14 | JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397) | 3.26843374 |
| 15 | T-helper cell differentiation (GO:0042093) | 3.24266052 |
| 16 | CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294) | 3.24266052 |
| 17 | cellular response to arsenic-containing substance (GO:0071243) | 3.22496327 |
| 18 | positive regulation by symbiont of host defense response (GO:0052509) | 3.21070401 |
| 19 | modulation by symbiont of host defense response (GO:0052031) | 3.21070401 |
| 20 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 3.21070401 |
| 21 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 3.21070401 |
| 22 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 3.21070401 |
| 23 | modulation by symbiont of host immune response (GO:0052553) | 3.21070401 |
| 24 | tolerance induction (GO:0002507) | 3.16796761 |
| 25 | response to muramyl dipeptide (GO:0032495) | 3.13017361 |
| 26 | positive thymic T cell selection (GO:0045059) | 3.12662457 |
| 27 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.11227982 |
| 28 | histone H3-K36 demethylation (GO:0070544) | 3.06306724 |
| 29 | regulation of vitamin D biosynthetic process (GO:0060556) | 3.06036387 |
| 30 | nuclear pore organization (GO:0006999) | 3.01690851 |
| 31 | positive regulation of p38MAPK cascade (GO:1900745) | 2.94702976 |
| 32 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 2.89416957 |
| 33 | detection of molecule of bacterial origin (GO:0032490) | 2.89121932 |
| 34 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 2.87322221 |
| 35 | growth hormone receptor signaling pathway (GO:0060396) | 2.86770083 |
| 36 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 2.86613386 |
| 37 | alpha-beta T cell differentiation involved in immune response (GO:0002293) | 2.86282440 |
| 38 | alpha-beta T cell activation involved in immune response (GO:0002287) | 2.86282440 |
| 39 | T cell differentiation involved in immune response (GO:0002292) | 2.86282440 |
| 40 | detection of other organism (GO:0098543) | 2.83356296 |
| 41 | regulation of interferon-alpha production (GO:0032647) | 2.82483372 |
| 42 | nuclear pore complex assembly (GO:0051292) | 2.81717916 |
| 43 | positive regulation of interferon-alpha production (GO:0032727) | 2.79676472 |
| 44 | necroptotic process (GO:0070266) | 2.77754981 |
| 45 | germinal center formation (GO:0002467) | 2.76802059 |
| 46 | negative T cell selection (GO:0043383) | 2.76502713 |
| 47 | negative thymic T cell selection (GO:0045060) | 2.76482045 |
| 48 | regulation of nitric-oxide synthase biosynthetic process (GO:0051769) | 2.75551438 |
| 49 | monoubiquitinated protein deubiquitination (GO:0035520) | 2.75274523 |
| 50 | neutrophil activation involved in immune response (GO:0002283) | 2.74754439 |
| 51 | regulation of T cell tolerance induction (GO:0002664) | 2.74277576 |
| 52 | positive regulation of protein homooligomerization (GO:0032464) | 2.73923037 |
| 53 | regulation of interferon-beta biosynthetic process (GO:0045357) | 2.72565567 |
| 54 | regulation of RNA export from nucleus (GO:0046831) | 2.71855689 |
| 55 | negative regulation of B cell proliferation (GO:0030889) | 2.71774889 |
| 56 | B cell homeostasis (GO:0001782) | 2.71081000 |
| 57 | membrane raft organization (GO:0031579) | 2.68680323 |
| 58 | COPI coating of Golgi vesicle (GO:0048205) | 2.67097545 |
| 59 | Golgi transport vesicle coating (GO:0048200) | 2.67097545 |
| 60 | positive regulation of interferon-beta production (GO:0032728) | 2.65640763 |
| 61 | neutrophil activation (GO:0042119) | 2.62320832 |
| 62 | ribosome assembly (GO:0042255) | 2.61986520 |
| 63 | myeloid dendritic cell activation (GO:0001773) | 2.61813047 |
| 64 | thymic T cell selection (GO:0045061) | 2.60203829 |
| 65 | myeloid dendritic cell differentiation (GO:0043011) | 2.59268891 |
| 66 | embryonic process involved in female pregnancy (GO:0060136) | 2.58606358 |
| 67 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369) | 2.57974516 |
| 68 | granulocyte activation (GO:0036230) | 2.57771770 |
| 69 | immunoglobulin mediated immune response (GO:0016064) | 2.56215427 |
| 70 | cytoplasmic mRNA processing body assembly (GO:0033962) | 2.56027023 |
| 71 | regulation of p38MAPK cascade (GO:1900744) | 2.54644874 |
| 72 | iron ion import (GO:0097286) | 2.52856533 |
| 73 | regulation of interferon-beta production (GO:0032648) | 2.51852823 |
| 74 | positive regulation of B cell differentiation (GO:0045579) | 2.51551899 |
| 75 | positive regulation of isotype switching (GO:0045830) | 2.51037890 |
| 76 | regulation of response to interferon-gamma (GO:0060330) | 2.50460049 |
| 77 | cellular response to interleukin-15 (GO:0071350) | 2.49940768 |
| 78 | positive regulation of interleukin-12 production (GO:0032735) | 2.49900608 |
| 79 | nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423) | 2.49194680 |
| 80 | negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665) | 2.48531934 |
| 81 | leukocyte aggregation (GO:0070486) | 2.48052419 |
| 82 | mRNA transcription (GO:0009299) | 2.47190645 |
| 83 | macrophage activation involved in immune response (GO:0002281) | 2.46926679 |
| 84 | interferon-gamma-mediated signaling pathway (GO:0060333) | 2.46784054 |
| 85 | response to interleukin-15 (GO:0070672) | 2.46396082 |
| 86 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 2.46374645 |
| 87 | response to type I interferon (GO:0034340) | 2.46193283 |
| 88 | CD4-positive, alpha-beta T cell differentiation (GO:0043367) | 2.46054288 |
| 89 | leukocyte cell-cell adhesion (GO:0007159) | 2.45932320 |
| 90 | intestinal epithelial cell development (GO:0060576) | 2.45521601 |
| 91 | leukocyte tethering or rolling (GO:0050901) | 2.44769773 |
| 92 | positive T cell selection (GO:0043368) | 2.44746023 |
| 93 | tyrosine phosphorylation of STAT protein (GO:0007260) | 2.44266085 |
| 94 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 2.43854148 |
| 95 | pore complex assembly (GO:0046931) | 2.42590573 |
| 96 | T cell activation involved in immune response (GO:0002286) | 2.42578515 |
| 97 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 2.41549384 |
| 98 | definitive hemopoiesis (GO:0060216) | 2.40848386 |
| 99 | regulation of interleukin-8 biosynthetic process (GO:0045414) | 2.40743587 |
| 100 | regulation of alpha-beta T cell proliferation (GO:0046640) | 2.40603333 |
| 101 | type I interferon signaling pathway (GO:0060337) | 2.40464126 |
| 102 | cellular response to type I interferon (GO:0071357) | 2.40464126 |
| 103 | positive regulation of tumor necrosis factor biosynthetic process (GO:0042535) | 2.40161611 |
| 104 | negative regulation of bone resorption (GO:0045779) | 2.39900638 |
| 105 | cellular response to growth hormone stimulus (GO:0071378) | 2.39415247 |
| 106 | regulation of B cell differentiation (GO:0045577) | 2.39276521 |
| 107 | I-kappaB phosphorylation (GO:0007252) | 2.39263058 |
| 108 | positive regulation of keratinocyte differentiation (GO:0045618) | 2.39037549 |
| 109 | T cell selection (GO:0045058) | 2.38509521 |
| 110 | regulation of B cell proliferation (GO:0030888) | 2.38285320 |
| 111 | response to protozoan (GO:0001562) | 2.38182967 |
| 112 | regulation of fibroblast apoptotic process (GO:2000269) | 2.37630640 |
| 113 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 2.36108027 |
| 114 | response to host (GO:0075136) | 2.35549142 |
| 115 | dendritic cell migration (GO:0036336) | 2.35351444 |
| 116 | negative regulation of osteoblast proliferation (GO:0033689) | 2.34793613 |
| 117 | positive regulation of interleukin-2 production (GO:0032743) | 2.33116781 |
| 118 | negative regulation of interleukin-12 production (GO:0032695) | 2.32937224 |
| 119 | response to host immune response (GO:0052572) | 2.32797084 |
| 120 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 2.32797084 |
| 121 | response to peptidoglycan (GO:0032494) | 2.32560557 |
| 122 | response to arsenic-containing substance (GO:0046685) | 2.31779408 |
| 123 | lymph node development (GO:0048535) | 2.31540554 |
| 124 | negative regulation of lipid storage (GO:0010888) | 2.30870885 |
| 125 | regulation of nucleobase-containing compound transport (GO:0032239) | 2.30412182 |
| 126 | alpha-beta T cell activation (GO:0046631) | 2.29718638 |
| 127 | detection of bacterium (GO:0016045) | 2.29317490 |
| 128 | cellular response to ethanol (GO:0071361) | 2.29277909 |
| 129 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 2.29099955 |
| 130 | mRNA transcription from RNA polymerase II promoter (GO:0042789) | 2.29012164 |
| 131 | cellular extravasation (GO:0045123) | 2.28708985 |
| 132 | T cell migration (GO:0072678) | 2.28462038 |
| 133 | cytoplasmic pattern recognition receptor signaling pathway (GO:0002753) | 2.27557985 |
| 134 | detection of external biotic stimulus (GO:0098581) | 2.27354532 |
| 135 | regulation of vitamin metabolic process (GO:0030656) | 2.27027848 |
| 136 | programmed necrotic cell death (GO:0097300) | 2.26664982 |
| 137 | mature B cell differentiation (GO:0002335) | 2.26305999 |
| 138 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 2.26186997 |
| 139 | response to host defenses (GO:0052200) | 2.26186997 |
| 140 | defense response to protozoan (GO:0042832) | 2.25862164 |
| 141 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 2.24549213 |
| 142 | B cell mediated immunity (GO:0019724) | 2.24180768 |
| 143 | mitotic sister chromatid cohesion (GO:0007064) | 2.23026233 |
| 144 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 2.21922536 |
| 145 | necrotic cell death (GO:0070265) | 2.21562368 |
| 146 | hypotonic response (GO:0006971) | 2.21131827 |
| 147 | positive regulation of cytokine biosynthetic process (GO:0042108) | 2.20947513 |
| 148 | response to dsRNA (GO:0043331) | 2.20730514 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 5.50542754 |
| 2 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 4.67907524 |
| 3 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 4.64540421 |
| 4 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 4.21213856 |
| 5 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 3.37959182 |
| 6 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 3.29725096 |
| 7 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 3.23004536 |
| 8 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 3.12609436 |
| 9 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.01486315 |
| 10 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.96753253 |
| 11 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.77510150 |
| 12 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.74449003 |
| 13 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.61739270 |
| 14 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.55785415 |
| 15 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.53558156 |
| 16 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 2.51867744 |
| 17 | * FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 2.50557972 |
| 18 | MYB_26560356_Chip-Seq_TH2_Human | 2.45974765 |
| 19 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.45498072 |
| 20 | RUNX_20019798_ChIP-Seq_JUKART_Human | 2.25986397 |
| 21 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.14469760 |
| 22 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 2.13715922 |
| 23 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 2.11603524 |
| 24 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 2.08825183 |
| 25 | * MYB_26560356_Chip-Seq_TH1_Human | 2.07323713 |
| 26 | TFEB_21752829_ChIP-Seq_HELA_Human | 2.00515314 |
| 27 | MYC_22102868_ChIP-Seq_BL_Human | 1.96551165 |
| 28 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.95039022 |
| 29 | MAF_26560356_Chip-Seq_TH1_Human | 1.94139449 |
| 30 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.89158485 |
| 31 | * STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.88950610 |
| 32 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.81067948 |
| 33 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.79732619 |
| 34 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.72833516 |
| 35 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.71498644 |
| 36 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.70840739 |
| 37 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.64448896 |
| 38 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.63388983 |
| 39 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.61972612 |
| 40 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.61477461 |
| 41 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.56484740 |
| 42 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.55398962 |
| 43 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.54174273 |
| 44 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.53921390 |
| 45 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.50189620 |
| 46 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.48758825 |
| 47 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.47304660 |
| 48 | GATA1_22025678_ChIP-Seq_K562_Human | 1.47036727 |
| 49 | * VDR_23849224_ChIP-Seq_CD4+_Human | 1.46931051 |
| 50 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.45284561 |
| 51 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.44417742 |
| 52 | UTX_26944678_Chip-Seq_JUKART_Human | 1.41625728 |
| 53 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.39129600 |
| 54 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.36849638 |
| 55 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.36534777 |
| 56 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.35660775 |
| 57 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.35660775 |
| 58 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.32515620 |
| 59 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.30742688 |
| 60 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.28512644 |
| 61 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.27267055 |
| 62 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.26328361 |
| 63 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.23422252 |
| 64 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.23211475 |
| 65 | * CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.22387277 |
| 66 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.22374460 |
| 67 | GATA3_26560356_Chip-Seq_TH2_Human | 1.22309178 |
| 68 | * GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.21514383 |
| 69 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.21236622 |
| 70 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.20596488 |
| 71 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 1.20556756 |
| 72 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.20494608 |
| 73 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.19860506 |
| 74 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.19700029 |
| 75 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.18931665 |
| 76 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.18101801 |
| 77 | * CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.17986975 |
| 78 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.17550668 |
| 79 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.15804199 |
| 80 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.14415377 |
| 81 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.14326980 |
| 82 | ELF5_23300383_ChIP-Seq_T47D_Human | 1.13179316 |
| 83 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 1.10661617 |
| 84 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.10658119 |
| 85 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.10477404 |
| 86 | ATF3_27146783_Chip-Seq_COLON_Human | 1.09532195 |
| 87 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.09479042 |
| 88 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.09313785 |
| 89 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.06949783 |
| 90 | * DCP1A_22483619_ChIP-Seq_HELA_Human | 1.06142443 |
| 91 | * NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.06009418 |
| 92 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.05986733 |
| 93 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.05893018 |
| 94 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.04395504 |
| 95 | CHD1_26751641_Chip-Seq_LNCaP_Human | 1.04304009 |
| 96 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.03474304 |
| 97 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.03147370 |
| 98 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.02342363 |
| 99 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.01909838 |
| 100 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.01180803 |
| 101 | CJUN_26792858_Chip-Seq_BT549_Human | 1.00800025 |
| 102 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.00624520 |
| 103 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.99769963 |
| 104 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 0.98314125 |
| 105 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.97190998 |
| 106 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 0.96919491 |
| 107 | * CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.96646785 |
| 108 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.94677765 |
| 109 | * RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 0.94647773 |
| 110 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.93711778 |
| 111 | UBF1/2_26484160_Chip-Seq_HMECs_Human | 0.93648301 |
| 112 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.93619492 |
| 113 | RXR_22108803_ChIP-Seq_LS180_Human | 0.93566361 |
| 114 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.93520713 |
| 115 | * TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.93306316 |
| 116 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.93088635 |
| 117 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 0.92463121 |
| 118 | GATA4_25053715_ChIP-Seq_YYC3_Human | 0.92257300 |
| 119 | GATA6_25053715_ChIP-Seq_YYC3_Human | 0.91850114 |
| 120 | * DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.91702473 |
| 121 | BRD4_25478319_ChIP-Seq_HGPS_Human | 0.91668841 |
| 122 | SPI1_23127762_ChIP-Seq_K562_Human | 0.91597107 |
| 123 | * GATA2_22383799_ChIP-Seq_G1ME_Mouse | 0.91423678 |
| 124 | * KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.90812953 |
| 125 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.90744067 |
| 126 | * FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human | 0.89963565 |
| 127 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.89736248 |
| 128 | GATA2_19941826_ChIP-Seq_K562_Human | 0.89494653 |
| 129 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.88774326 |
| 130 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.88600217 |
| 131 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.88425224 |
| 132 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 0.88052513 |
| 133 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.87239189 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008057_abnormal_DNA_replication | 3.29752734 |
| 2 | MP0001835_abnormal_antigen_presentation | 2.91594939 |
| 3 | MP0005671_abnormal_response_to | 2.58764908 |
| 4 | MP0003300_gastrointestinal_ulcer | 2.51019669 |
| 5 | MP0003436_decreased_susceptibility_to | 2.41541927 |
| 6 | MP0001790_abnormal_immune_system | 2.37218274 |
| 7 | MP0005387_immune_system_phenotype | 2.37218274 |
| 8 | MP0003303_peritoneal_inflammation | 2.33423981 |
| 9 | MP0005000_abnormal_immune_tolerance | 2.32786681 |
| 10 | MP0003724_increased_susceptibility_to | 2.24492593 |
| 11 | MP0001800_abnormal_humoral_immune | 2.24040619 |
| 12 | MP0002166_altered_tumor_susceptibility | 2.23499845 |
| 13 | MP0004947_skin_inflammation | 2.19971585 |
| 14 | MP0003183_abnormal_peptide_metabolism | 2.13914597 |
| 15 | MP0005310_abnormal_salivary_gland | 2.13068070 |
| 16 | MP0002452_abnormal_antigen_presenting | 2.10725793 |
| 17 | MP0000685_abnormal_immune_system | 2.07490113 |
| 18 | MP0009785_altered_susceptibility_to | 2.03286117 |
| 19 | MP0002723_abnormal_immune_serum | 2.02549081 |
| 20 | MP0002405_respiratory_system_inflammati | 2.02506545 |
| 21 | MP0003656_abnormal_erythrocyte_physiolo | 2.00115885 |
| 22 | MP0002148_abnormal_hypersensitivity_rea | 1.99728816 |
| 23 | MP0010155_abnormal_intestine_physiology | 1.92530314 |
| 24 | MP0002006_tumorigenesis | 1.92422672 |
| 25 | MP0002419_abnormal_innate_immunity | 1.92392477 |
| 26 | MP0003763_abnormal_thymus_physiology | 1.92367652 |
| 27 | MP0001873_stomach_inflammation | 1.92115983 |
| 28 | MP0002009_preneoplasia | 1.86690808 |
| 29 | MP0001819_abnormal_immune_cell | 1.84627867 |
| 30 | MP0002420_abnormal_adaptive_immunity | 1.84330400 |
| 31 | MP0002138_abnormal_hepatobiliary_system | 1.82207085 |
| 32 | MP0006082_CNS_inflammation | 1.76733175 |
| 33 | MP0010352_gastrointestinal_tract_polyps | 1.76729236 |
| 34 | MP0005451_abnormal_body_composition | 1.76179797 |
| 35 | MP0003828_pulmonary_edema | 1.68153204 |
| 36 | MP0005025_abnormal_response_to | 1.66019545 |
| 37 | MP0005076_abnormal_cell_differentiation | 1.65127214 |
| 38 | MP0002877_abnormal_melanocyte_morpholog | 1.60403479 |
| 39 | MP0001533_abnormal_skeleton_physiology | 1.59443982 |
| 40 | MP0000465_gastrointestinal_hemorrhage | 1.58767637 |
| 41 | MP0002398_abnormal_bone_marrow | 1.58713832 |
| 42 | MP0004510_myositis | 1.55695408 |
| 43 | MP0001845_abnormal_inflammatory_respons | 1.53318885 |
| 44 | MP0003950_abnormal_plasma_membrane | 1.51701249 |
| 45 | MP0000716_abnormal_immune_system | 1.50442801 |
| 46 | MP0003221_abnormal_cardiomyocyte_apopto | 1.48982225 |
| 47 | MP0002933_joint_inflammation | 1.45402249 |
| 48 | MP0004808_abnormal_hematopoietic_stem | 1.41915860 |
| 49 | MP0004381_abnormal_hair_follicle | 1.41773454 |
| 50 | MP0002277_abnormal_respiratory_mucosa | 1.41176580 |
| 51 | MP0003566_abnormal_cell_adhesion | 1.39525718 |
| 52 | MP0002254_reproductive_system_inflammat | 1.34964543 |
| 53 | MP0001853_heart_inflammation | 1.34723702 |
| 54 | MP0002722_abnormal_immune_system | 1.33185047 |
| 55 | MP0002998_abnormal_bone_remodeling | 1.33062482 |
| 56 | MP0005397_hematopoietic_system_phenotyp | 1.29248142 |
| 57 | MP0001545_abnormal_hematopoietic_system | 1.29248142 |
| 58 | MP0005464_abnormal_platelet_physiology | 1.29080966 |
| 59 | MP0002396_abnormal_hematopoietic_system | 1.28968981 |
| 60 | MP0000689_abnormal_spleen_morphology | 1.27201504 |
| 61 | MP0003448_altered_tumor_morphology | 1.26728422 |
| 62 | MP0009333_abnormal_splenocyte_physiolog | 1.26562173 |
| 63 | MP0009278_abnormal_bone_marrow | 1.25015191 |
| 64 | MP0010307_abnormal_tumor_latency | 1.22798982 |
| 65 | MP0002429_abnormal_blood_cell | 1.20741226 |
| 66 | MP0003453_abnormal_keratinocyte_physiol | 1.20483464 |
| 67 | MP0000569_abnormal_digit_pigmentation | 1.19133363 |
| 68 | MP0006054_spinal_hemorrhage | 1.19044745 |
| 69 | MP0010234_abnormal_vibrissa_follicle | 1.18920464 |
| 70 | MP0008260_abnormal_autophagy | 1.18808684 |
| 71 | MP0000858_altered_metastatic_potential | 1.18691724 |
| 72 | MP0008995_early_reproductive_senescence | 1.17965870 |
| 73 | MP0000490_abnormal_crypts_of | 1.15944345 |
| 74 | MP0003091_abnormal_cell_migration | 1.15861753 |
| 75 | MP0002796_impaired_skin_barrier | 1.15182527 |
| 76 | MP0000703_abnormal_thymus_morphology | 1.12034404 |
| 77 | MP0009840_abnormal_foam_cell | 1.10715235 |
| 78 | MP0003866_abnormal_defecation | 1.10549138 |
| 79 | MP0010678_abnormal_skin_adnexa | 1.05894236 |
| 80 | MP0009764_decreased_sensitivity_to | 1.04743076 |
| 81 | MP0003045_fibrosis | 1.03720719 |
| 82 | MP0002060_abnormal_skin_morphology | 1.03146615 |
| 83 | MP0008438_abnormal_cutaneous_collagen | 1.02983472 |
| 84 | MP0008469_abnormal_protein_level | 1.01652827 |
| 85 | MP0005390_skeleton_phenotype | 1.01245553 |
| 86 | MP0003795_abnormal_bone_structure | 1.01067874 |
| 87 | MP0009384_cardiac_valve_regurgitation | 0.99565510 |
| 88 | MP0002132_abnormal_respiratory_system | 0.98869033 |
| 89 | MP0001216_abnormal_epidermal_layer | 0.96571973 |
| 90 | MP0005275_abnormal_skin_tensile | 0.96327159 |
| 91 | MP0003077_abnormal_cell_cycle | 0.96308495 |
| 92 | MP0005164_abnormal_response_to | 0.96134106 |
| 93 | MP0005023_abnormal_wound_healing | 0.95984858 |
| 94 | MP0001851_eye_inflammation | 0.95700701 |
| 95 | MP0003172_abnormal_lysosome_physiology | 0.93902354 |
| 96 | MP0000015_abnormal_ear_pigmentation | 0.91864959 |
| 97 | MP0002332_abnormal_exercise_endurance | 0.88712655 |
| 98 | MP0002928_abnormal_bile_duct | 0.87506378 |
| 99 | MP0000627_abnormal_mammary_gland | 0.85965908 |
| 100 | MP0005621_abnormal_cell_physiology | 0.85042615 |
| 101 | MP0001542_abnormal_bone_strength | 0.83828317 |
| 102 | MP0003693_abnormal_embryo_hatching | 0.82636085 |
| 103 | MP0000371_diluted_coat_color | 0.82498501 |
| 104 | MP0003786_premature_aging | 0.80188403 |
| 105 | MP0001727_abnormal_embryo_implantation | 0.79871865 |
| 106 | MP0001191_abnormal_skin_condition | 0.79224185 |
| 107 | MP0000350_abnormal_cell_proliferation | 0.78037708 |
| 108 | MP0002693_abnormal_pancreas_physiology | 0.76607313 |
| 109 | MP0008007_abnormal_cellular_replicative | 0.76549578 |
| 110 | MP0001879_abnormal_lymphatic_vessel | 0.76078700 |
| 111 | MP0002019_abnormal_tumor_incidence | 0.75875336 |
| 112 | MP0005501_abnormal_skin_physiology | 0.75820848 |
| 113 | MP0009931_abnormal_skin_appearance | 0.75493168 |
| 114 | MP0000249_abnormal_blood_vessel | 0.75467392 |
| 115 | MP0001243_abnormal_dermal_layer | 0.75463023 |
| 116 | MP0004883_abnormal_blood_vessel | 0.74437234 |
| 117 | MP0002136_abnormal_kidney_physiology | 0.74123726 |
| 118 | MP0000343_altered_response_to | 0.73627454 |
| 119 | MP0004264_abnormal_extraembryonic_tissu | 0.73315560 |
| 120 | MP0001881_abnormal_mammary_gland | 0.73229826 |
| 121 | MP0004233_abnormal_muscle_weight | 0.73132259 |
| 122 | MP0003191_abnormal_cellular_cholesterol | 0.72521742 |
| 123 | MP0003252_abnormal_bile_duct | 0.70592669 |
| 124 | MP0002163_abnormal_gland_morphology | 0.68216966 |
| 125 | MP0000767_abnormal_smooth_muscle | 0.68164309 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Optic neuritis (HP:0100653) | 4.44606111 |
| 2 | Retrobulbar optic neuritis (HP:0100654) | 4.44606111 |
| 3 | Orchitis (HP:0100796) | 4.22388492 |
| 4 | Myositis (HP:0100614) | 4.03162596 |
| 5 | Eczematoid dermatitis (HP:0000976) | 3.72096365 |
| 6 | Subacute progressive viral hepatitis (HP:0006572) | 3.30339131 |
| 7 | Cutaneous melanoma (HP:0012056) | 3.26242859 |
| 8 | IgM deficiency (HP:0002850) | 3.10033530 |
| 9 | Keratoconjunctivitis sicca (HP:0001097) | 3.06350856 |
| 10 | Stomatitis (HP:0010280) | 3.05282991 |
| 11 | Arterial thrombosis (HP:0004420) | 2.93345936 |
| 12 | Recurrent fungal infections (HP:0002841) | 2.88986574 |
| 13 | Recurrent abscess formation (HP:0002722) | 2.82803082 |
| 14 | Periodontitis (HP:0000704) | 2.79351574 |
| 15 | Osteolytic defects of the hand bones (HP:0009699) | 2.76719865 |
| 16 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 2.76719865 |
| 17 | Keratoconjunctivitis (HP:0001096) | 2.74014304 |
| 18 | Viral hepatitis (HP:0006562) | 2.72203737 |
| 19 | Persistence of primary teeth (HP:0006335) | 2.71338603 |
| 20 | Recurrent bacterial skin infections (HP:0005406) | 2.67343811 |
| 21 | Abnormal foot bone ossification (HP:0010675) | 2.64274468 |
| 22 | Curly hair (HP:0002212) | 2.57902437 |
| 23 | Micronodular cirrhosis (HP:0001413) | 2.57031862 |
| 24 | Vasculitis (HP:0002633) | 2.55898942 |
| 25 | Abnormality of T cell number (HP:0011839) | 2.55608220 |
| 26 | Albinism (HP:0001022) | 2.54253523 |
| 27 | Myocardial infarction (HP:0001658) | 2.54245223 |
| 28 | Pulmonary infiltrates (HP:0002113) | 2.54041168 |
| 29 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.52707537 |
| 30 | Autoimmune thrombocytopenia (HP:0001973) | 2.51012796 |
| 31 | Recurrent viral infections (HP:0004429) | 2.49912755 |
| 32 | Lip pit (HP:0100267) | 2.48815482 |
| 33 | Abnormality of the fingertips (HP:0001211) | 2.48264780 |
| 34 | Hematochezia (HP:0002573) | 2.43868709 |
| 35 | T lymphocytopenia (HP:0005403) | 2.43852929 |
| 36 | Amaurosis fugax (HP:0100576) | 2.40705808 |
| 37 | Aortic aneurysm (HP:0004942) | 2.40244885 |
| 38 | Papillary thyroid carcinoma (HP:0002895) | 2.39762264 |
| 39 | Absent frontal sinuses (HP:0002688) | 2.39248509 |
| 40 | Recurrent bronchitis (HP:0002837) | 2.36452163 |
| 41 | Chronic diarrhea (HP:0002028) | 2.34293087 |
| 42 | Increased IgE level (HP:0003212) | 2.31511354 |
| 43 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 2.29380870 |
| 44 | Abnormality of glycolipid metabolism (HP:0010969) | 2.29380870 |
| 45 | Abnormality of liposaccharide metabolism (HP:0010968) | 2.29380870 |
| 46 | Abnormality of nail color (HP:0100643) | 2.28379836 |
| 47 | Cerebral aneurysm (HP:0004944) | 2.27274161 |
| 48 | Neoplasm of the tracheobronchial system (HP:0100552) | 2.25933444 |
| 49 | IgA deficiency (HP:0002720) | 2.25226993 |
| 50 | Abnormality of the distal phalanges of the toes (HP:0010182) | 2.25204349 |
| 51 | Pustule (HP:0200039) | 2.23492297 |
| 52 | Nasal polyposis (HP:0100582) | 2.23337270 |
| 53 | Spondylolisthesis (HP:0003302) | 2.23286114 |
| 54 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.20815352 |
| 55 | Gingivitis (HP:0000230) | 2.19811375 |
| 56 | Eosinophilia (HP:0001880) | 2.17669222 |
| 57 | Interstitial pulmonary disease (HP:0006530) | 2.17072962 |
| 58 | Alveolar cell carcinoma (HP:0006519) | 2.13638363 |
| 59 | Squamous cell carcinoma (HP:0002860) | 2.12394245 |
| 60 | Autoimmune hemolytic anemia (HP:0001890) | 2.11403349 |
| 61 | Tetraparesis (HP:0002273) | 2.10680209 |
| 62 | Spontaneous hematomas (HP:0007420) | 2.10673618 |
| 63 | Hemoptysis (HP:0002105) | 2.08183549 |
| 64 | Urticaria (HP:0001025) | 2.07780626 |
| 65 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.07693082 |
| 66 | Abnormality of macrophages (HP:0004311) | 2.07655461 |
| 67 | Cellulitis (HP:0100658) | 2.07597330 |
| 68 | Thyroid carcinoma (HP:0002890) | 2.07256131 |
| 69 | Prostate neoplasm (HP:0100787) | 2.06517682 |
| 70 | Abnormality of T cells (HP:0002843) | 2.05757978 |
| 71 | Fatigue (HP:0012378) | 2.05406059 |
| 72 | Hepatitis (HP:0012115) | 2.04921384 |
| 73 | Thyroiditis (HP:0100646) | 2.04439029 |
| 74 | Vertebral compression fractures (HP:0002953) | 2.04286084 |
| 75 | Spinal cord lesions (HP:0100561) | 2.03482713 |
| 76 | Syringomyelia (HP:0003396) | 2.03482713 |
| 77 | Leukocytosis (HP:0001974) | 2.03181470 |
| 78 | Encephalitis (HP:0002383) | 2.02996145 |
| 79 | Mediastinal lymphadenopathy (HP:0100721) | 2.02979056 |
| 80 | Cheilitis (HP:0100825) | 2.02661418 |
| 81 | Gastrointestinal infarctions (HP:0005244) | 2.02537484 |
| 82 | Abnormality of eosinophils (HP:0001879) | 2.01247347 |
| 83 | Onycholysis (HP:0001806) | 1.99706119 |
| 84 | Chronic otitis media (HP:0000389) | 1.97151633 |
| 85 | Abnormality of the nasal septum (HP:0000419) | 1.97033975 |
| 86 | Abnormality of T cell physiology (HP:0011840) | 1.96225103 |
| 87 | Sparse lateral eyebrow (HP:0005338) | 1.95332765 |
| 88 | Meningitis (HP:0001287) | 1.94856787 |
| 89 | Prominent nose (HP:0000448) | 1.92867605 |
| 90 | Entropion (HP:0000621) | 1.92588339 |
| 91 | Somatic mutation (HP:0001428) | 1.92442976 |
| 92 | Increased CSF protein (HP:0002922) | 1.92146520 |
| 93 | Anorexia (HP:0002039) | 1.91680043 |
| 94 | IgG deficiency (HP:0004315) | 1.91497396 |
| 95 | Lymphopenia (HP:0001888) | 1.91253903 |
| 96 | Neonatal hypoglycemia (HP:0001998) | 1.87932836 |
| 97 | Submucous cleft hard palate (HP:0000176) | 1.87112403 |
| 98 | Lymphoma (HP:0002665) | 1.87066821 |
| 99 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 1.86417107 |
| 100 | Asymmetry of the thorax (HP:0001555) | 1.86388185 |
| 101 | Acute hepatic failure (HP:0006554) | 1.85975524 |
| 102 | Abnormality of proline metabolism (HP:0010907) | 1.85491474 |
| 103 | Hydroxyprolinuria (HP:0003080) | 1.85491474 |
| 104 | Lower limb hyperreflexia (HP:0002395) | 1.85133016 |
| 105 | Aplasia cutis congenita (HP:0001057) | 1.84581208 |
| 106 | Deep philtrum (HP:0002002) | 1.84476665 |
| 107 | Aplasia/Hypoplasia of the frontal sinuses (HP:0009119) | 1.84371141 |
| 108 | Osteomyelitis (HP:0002754) | 1.83960316 |
| 109 | Recurrent skin infections (HP:0001581) | 1.83877047 |
| 110 | Abnormality of the nasal mucosa (HP:0000433) | 1.83817049 |
| 111 | Aortic dissection (HP:0002647) | 1.83630648 |
| 112 | Coarse hair (HP:0002208) | 1.82988900 |
| 113 | Gastrointestinal stroma tumor (HP:0100723) | 1.82466308 |
| 114 | Acute myeloid leukemia (HP:0004808) | 1.82208451 |
| 115 | Chronic obstructive pulmonary disease (HP:0006510) | 1.81811694 |
| 116 | Obstructive lung disease (HP:0006536) | 1.81811694 |
| 117 | Verrucae (HP:0200043) | 1.81049877 |
| 118 | Papilloma (HP:0012740) | 1.81049877 |
| 119 | Metaphyseal dysplasia (HP:0100255) | 1.81028828 |
| 120 | Keratitis (HP:0000491) | 1.80159376 |
| 121 | Chronic mucocutaneous candidiasis (HP:0002728) | 1.79968575 |
| 122 | Recurrent cutaneous fungal infections (HP:0011370) | 1.79968575 |
| 123 | Increased IgM level (HP:0003496) | 1.79806197 |
| 124 | Abnormality of oral frenula (HP:0000190) | 1.79458482 |
| 125 | Thoracolumbar scoliosis (HP:0002944) | 1.79344751 |
| 126 | Inflammation of the large intestine (HP:0002037) | 1.78950903 |
| 127 | Recurrent sinusitis (HP:0011108) | 1.78445799 |
| 128 | Abnormal pancreas size (HP:0012094) | 1.78141666 |
| 129 | Glomerulopathy (HP:0100820) | 1.76088012 |
| 130 | Thick nail (HP:0001805) | 1.76031796 |
| 131 | Hypoplastic ischia (HP:0003175) | 1.75977992 |
| 132 | Arthralgia (HP:0002829) | 1.74963661 |
| 133 | Joint swelling (HP:0001386) | 1.74935564 |
| 134 | Melanoma (HP:0002861) | 1.74501791 |
| 135 | Colitis (HP:0002583) | 1.73975978 |
| 136 | Emphysema (HP:0002097) | 1.73942826 |
| 137 | Granulocytopenia (HP:0001913) | 1.73523747 |
| 138 | Vacuolated lymphocytes (HP:0001922) | 1.71415339 |
| 139 | Skin ulcer (HP:0200042) | 1.71173280 |
| 140 | Deep palmar crease (HP:0006191) | 1.69786206 |
| 141 | Alopecia of scalp (HP:0002293) | 1.68466663 |
| 142 | Gangrene (HP:0100758) | 1.68396074 |
| 143 | Basal cell carcinoma (HP:0002671) | 1.68025236 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EPHA3 | 5.39846380 |
| 2 | EIF2AK3 | 3.38641465 |
| 3 | PRPF4B | 3.23878467 |
| 4 | MAP3K14 | 3.10107353 |
| 5 | MAP4K1 | 2.78184069 |
| 6 | TXK | 2.67937659 |
| 7 | IRAK3 | 2.42392888 |
| 8 | TAOK3 | 2.37561556 |
| 9 | TBK1 | 2.22071717 |
| 10 | JAK3 | 2.19567097 |
| 11 | IRAK4 | 2.13971920 |
| 12 | BLK | 2.06042277 |
| 13 | NUAK1 | 2.03460314 |
| 14 | FRK | 2.01741585 |
| 15 | IKBKE | 1.94543287 |
| 16 | CHUK | 1.88312791 |
| 17 | IKBKB | 1.87215789 |
| 18 | JAK1 | 1.84616807 |
| 19 | TEC | 1.81544173 |
| 20 | ITK | 1.81010758 |
| 21 | STK10 | 1.80306770 |
| 22 | TGFBR2 | 1.79121733 |
| 23 | EIF2AK1 | 1.77554471 |
| 24 | TYK2 | 1.76250526 |
| 25 | AKT3 | 1.66701217 |
| 26 | LATS1 | 1.57548574 |
| 27 | BRD4 | 1.57417264 |
| 28 | TAOK2 | 1.54046331 |
| 29 | FGFR3 | 1.53070675 |
| 30 | PIM1 | 1.50467989 |
| 31 | IRAK1 | 1.48586394 |
| 32 | MST4 | 1.44884693 |
| 33 | RIPK1 | 1.43269845 |
| 34 | CDK12 | 1.42739637 |
| 35 | FGFR4 | 1.41053373 |
| 36 | ZAP70 | 1.38389599 |
| 37 | ERN1 | 1.38384344 |
| 38 | MAP3K12 | 1.36668259 |
| 39 | STK3 | 1.32978768 |
| 40 | SCYL2 | 1.29540735 |
| 41 | MAPK15 | 1.28343344 |
| 42 | EPHA2 | 1.27929885 |
| 43 | RPS6KA4 | 1.27007296 |
| 44 | NLK | 1.25999158 |
| 45 | MAP3K13 | 1.24901474 |
| 46 | PDK2 | 1.24620246 |
| 47 | TRPM7 | 1.21858465 |
| 48 | BTK | 1.19156017 |
| 49 | MAP3K3 | 1.18867679 |
| 50 | ACVR1B | 1.17396899 |
| 51 | STK38L | 1.17102360 |
| 52 | STK24 | 1.13929972 |
| 53 | EPHB1 | 1.11755821 |
| 54 | CSK | 1.08874726 |
| 55 | MAP3K1 | 1.02569373 |
| 56 | YES1 | 1.00334787 |
| 57 | LATS2 | 0.99186578 |
| 58 | TSSK6 | 0.99120775 |
| 59 | PIM2 | 0.95990980 |
| 60 | NEK9 | 0.91363579 |
| 61 | SMG1 | 0.89714796 |
| 62 | EEF2K | 0.86822446 |
| 63 | PBK | 0.85281609 |
| 64 | LCK | 0.83456263 |
| 65 | HCK | 0.81172609 |
| 66 | MAP2K3 | 0.80147061 |
| 67 | PTK6 | 0.79445378 |
| 68 | MELK | 0.78832672 |
| 69 | HIPK2 | 0.78632412 |
| 70 | JAK2 | 0.78010799 |
| 71 | CDK9 | 0.75306815 |
| 72 | CDK6 | 0.74404487 |
| 73 | RPS6KB2 | 0.74253653 |
| 74 | KIT | 0.70883362 |
| 75 | KSR1 | 0.68817688 |
| 76 | SYK | 0.68660470 |
| 77 | PASK | 0.68421950 |
| 78 | MAP3K10 | 0.67289369 |
| 79 | WNK1 | 0.66342448 |
| 80 | STK4 | 0.65540023 |
| 81 | LYN | 0.64222381 |
| 82 | RIPK4 | 0.62060644 |
| 83 | TAF1 | 0.59126656 |
| 84 | MARK3 | 0.58312653 |
| 85 | ERBB3 | 0.57001836 |
| 86 | SIK1 | 0.56842909 |
| 87 | MOS | 0.55993717 |
| 88 | MST1R | 0.55777057 |
| 89 | CSF1R | 0.55286130 |
| 90 | NEK6 | 0.54547641 |
| 91 | PDGFRB | 0.52102956 |
| 92 | RPS6KA5 | 0.52041895 |
| 93 | ZAK | 0.51923979 |
| 94 | INSRR | 0.51356341 |
| 95 | MAPK7 | 0.50799911 |
| 96 | MAPKAPK2 | 0.50590099 |
| 97 | CLK1 | 0.50561940 |
| 98 | EIF2AK2 | 0.49550330 |
| 99 | MTOR | 0.49306789 |
| 100 | KSR2 | 0.47751478 |
| 101 | SIK3 | 0.47748195 |
| 102 | BMPR2 | 0.47239124 |
| 103 | LRRK2 | 0.46759025 |
| 104 | RAF1 | 0.44296067 |
| 105 | CDK4 | 0.43971235 |
| 106 | CAMKK2 | 0.43538875 |
| 107 | MATK | 0.42146795 |
| 108 | GSK3A | 0.41801964 |
| 109 | ERBB4 | 0.41639124 |
| 110 | BRSK2 | 0.40725010 |
| 111 | TRIM28 | 0.40022441 |
| 112 | ABL1 | 0.39930646 |
| 113 | ERBB2 | 0.39647696 |
| 114 | SGK3 | 0.39518054 |
| 115 | PIK3CA | 0.38858597 |
| 116 | IRAK2 | 0.38725823 |
| 117 | PLK4 | 0.36237774 |
| 118 | MKNK2 | 0.36150378 |
| 119 | CDK3 | 0.36089465 |
| 120 | GRK6 | 0.35515614 |
| 121 | PRKAA2 | 0.34030294 |
| 122 | CAMK1D | 0.33718399 |
| 123 | IGF1R | 0.33693944 |
| 124 | RPS6KA6 | 0.33333579 |
| 125 | MAP3K2 | 0.32908951 |
| 126 | RPS6KA1 | 0.31438741 |
| 127 | PRKCQ | 0.31334678 |
| 128 | PIK3CG | 0.31284946 |
| 129 | MAP3K5 | 0.29127053 |
| 130 | NEK2 | 0.26396663 |
| 131 | TAOK1 | 0.26285412 |
| 132 | MAP3K8 | 0.26206441 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.70650199 |
| 2 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.68926276 |
| 3 | Leishmaniasis_Homo sapiens_hsa05140 | 2.28278686 |
| 4 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.26946006 |
| 5 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.26628864 |
| 6 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.21610125 |
| 7 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.08226189 |
| 8 | Measles_Homo sapiens_hsa05162 | 2.05011381 |
| 9 | Allograft rejection_Homo sapiens_hsa05330 | 1.95557361 |
| 10 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.90573439 |
| 11 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.86736871 |
| 12 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.78164660 |
| 13 | Legionellosis_Homo sapiens_hsa05134 | 1.75375445 |
| 14 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.72667291 |
| 15 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.70219603 |
| 16 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.70155303 |
| 17 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.68958271 |
| 18 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.63151128 |
| 19 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.61880230 |
| 20 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.61153071 |
| 21 | Malaria_Homo sapiens_hsa05144 | 1.60532256 |
| 22 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.52028154 |
| 23 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.46257779 |
| 24 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.41794014 |
| 25 | Apoptosis_Homo sapiens_hsa04210 | 1.41576269 |
| 26 | Influenza A_Homo sapiens_hsa05164 | 1.38386102 |
| 27 | Hepatitis B_Homo sapiens_hsa05161 | 1.38231576 |
| 28 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.37970579 |
| 29 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.32963965 |
| 30 | Thyroid cancer_Homo sapiens_hsa05216 | 1.28732867 |
| 31 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.25766563 |
| 32 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.25636165 |
| 33 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.25367791 |
| 34 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.25152997 |
| 35 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 1.21926831 |
| 36 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.19789184 |
| 37 | Tuberculosis_Homo sapiens_hsa05152 | 1.16542990 |
| 38 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.14393599 |
| 39 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.13175193 |
| 40 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.12840999 |
| 41 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.11556734 |
| 42 | Bladder cancer_Homo sapiens_hsa05219 | 1.09726789 |
| 43 | Pertussis_Homo sapiens_hsa05133 | 1.09503895 |
| 44 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.08206637 |
| 45 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.08171703 |
| 46 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.08125204 |
| 47 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.04711717 |
| 48 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 1.02997496 |
| 49 | Asthma_Homo sapiens_hsa05310 | 0.96683729 |
| 50 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.96310006 |
| 51 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.94881865 |
| 52 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.94815446 |
| 53 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.93861273 |
| 54 | Hepatitis C_Homo sapiens_hsa05160 | 0.93504401 |
| 55 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.92054137 |
| 56 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.91776424 |
| 57 | Circadian rhythm_Homo sapiens_hsa04710 | 0.90807688 |
| 58 | Prostate cancer_Homo sapiens_hsa05215 | 0.89128510 |
| 59 | Lysosome_Homo sapiens_hsa04142 | 0.88417514 |
| 60 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.86942335 |
| 61 | HTLV-I infection_Homo sapiens_hsa05166 | 0.85452588 |
| 62 | Amoebiasis_Homo sapiens_hsa05146 | 0.85038359 |
| 63 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.84638750 |
| 64 | Shigellosis_Homo sapiens_hsa05131 | 0.82561890 |
| 65 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.80580768 |
| 66 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.80164866 |
| 67 | Viral myocarditis_Homo sapiens_hsa05416 | 0.79286164 |
| 68 | Platelet activation_Homo sapiens_hsa04611 | 0.77715334 |
| 69 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.75604615 |
| 70 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.74387775 |
| 71 | Salmonella infection_Homo sapiens_hsa05132 | 0.73929083 |
| 72 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.73099790 |
| 73 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.72638966 |
| 74 | RNA transport_Homo sapiens_hsa03013 | 0.72244579 |
| 75 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.71480840 |
| 76 | Basal transcription factors_Homo sapiens_hsa03022 | 0.70488606 |
| 77 | Other glycan degradation_Homo sapiens_hsa00511 | 0.69165196 |
| 78 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.67070972 |
| 79 | Focal adhesion_Homo sapiens_hsa04510 | 0.66816284 |
| 80 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.66773649 |
| 81 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.65603256 |
| 82 | Protein export_Homo sapiens_hsa03060 | 0.65313325 |
| 83 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.65071266 |
| 84 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.64563539 |
| 85 | Spliceosome_Homo sapiens_hsa03040 | 0.64048014 |
| 86 | Insulin resistance_Homo sapiens_hsa04931 | 0.63101964 |
| 87 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.61930276 |
| 88 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.61132734 |
| 89 | Adherens junction_Homo sapiens_hsa04520 | 0.60453846 |
| 90 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.59506834 |
| 91 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.58332955 |
| 92 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.56174725 |
| 93 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.55017263 |
| 94 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.54965895 |
| 95 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.54592091 |
| 96 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.53985739 |
| 97 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.53534872 |
| 98 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.51800248 |
| 99 | Phagosome_Homo sapiens_hsa04145 | 0.51090428 |
| 100 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.50020564 |
| 101 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.49793512 |
| 102 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.48836243 |
| 103 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.47683273 |
| 104 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.46955521 |
| 105 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.44887395 |
| 106 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.44850987 |
| 107 | Colorectal cancer_Homo sapiens_hsa05210 | 0.44453782 |
| 108 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.42636136 |
| 109 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.41797950 |
| 110 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.41423148 |
| 111 | Pathways in cancer_Homo sapiens_hsa05200 | 0.40391168 |
| 112 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.39330615 |
| 113 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.39140569 |
| 114 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.38960389 |
| 115 | Cell cycle_Homo sapiens_hsa04110 | 0.38823824 |
| 116 | Endometrial cancer_Homo sapiens_hsa05213 | 0.38018219 |
| 117 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.37946989 |
| 118 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.37299884 |

