ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	poly(A)+ mRNA export from nucleus (GO:0016973)	8.76677085
2	phosphatidylinositol acyl-chain remodeling (GO:0036149)	7.13298248
3	multicellular organism reproduction (GO:0032504)	6.64883167
4	sperm motility (GO:0030317)	6.37763658
5	phosphatidylserine acyl-chain remodeling (GO:0036150)	6.27781906
6	acrosome reaction (GO:0007340)	6.21028477
7	spermatid development (GO:0007286)	5.63890864
8	regulation of translational fidelity (GO:0006450)	5.37076442
9	regulation of meiosis I (GO:0060631)	5.24060204
10	modulation by virus of host process (GO:0019054)	5.18849576
11	male meiosis (GO:0007140)	5.09403318
12	sperm-egg recognition (GO:0035036)	5.07713784
13	negative regulation of viral entry into host cell (GO:0046597)	5.04693949
14	single fertilization (GO:0007338)	4.83156882
15	piRNA metabolic process (GO:0034587)	4.78214394
16	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	4.77866446
17	cilium or flagellum-dependent cell motility (GO:0001539)	4.64467272
18	reproduction (GO:0000003)	4.63511417
19	binding of sperm to zona pellucida (GO:0007339)	4.62387121
20	positive regulation of catecholamine secretion (GO:0033605)	4.60090447
21	epithelial cilium movement (GO:0003351)	4.59647555
22	protein polyglutamylation (GO:0018095)	4.52437249
23	regulation of phosphoprotein phosphatase activity (GO:0043666)	4.40870273
24	mitochondrion degradation (GO:0000422)	4.38717122
25	axonemal dynein complex assembly (GO:0070286)	4.37514098
26	cell-cell recognition (GO:0009988)	4.29244305
27	regulation of translational elongation (GO:0006448)	4.25490758
28	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	4.19107939
29	organic cation transport (GO:0015695)	4.13083836
30	phosphatidylcholine acyl-chain remodeling (GO:0036151)	4.05280650
31	neutrophil activation involved in immune response (GO:0002283)	3.99633008
32	DNA methylation involved in gamete generation (GO:0043046)	3.96135810
33	fusion of sperm to egg plasma membrane (GO:0007342)	3.94559742
34	motile cilium assembly (GO:0044458)	3.87713409
35	synapsis (GO:0007129)	3.86412877
36	cellular response to zinc ion (GO:0071294)	3.77639285
37	coenzyme catabolic process (GO:0009109)	3.75950567
38	basic amino acid transport (GO:0015802)	3.75382144
39	modulation by symbiont of host cellular process (GO:0044068)	3.69264881
40	rRNA methylation (GO:0031167)	3.68538614
41	regulation of viral entry into host cell (GO:0046596)	3.65779829
42	cellular ketone body metabolic process (GO:0046950)	3.65204339
43	rRNA modification (GO:0000154)	3.64486442
44	cilium movement (GO:0003341)	3.63777210
45	amino acid salvage (GO:0043102)	3.60096720
46	L-methionine salvage (GO:0071267)	3.60096720
47	L-methionine biosynthetic process (GO:0071265)	3.60096720
48	response to pheromone (GO:0019236)	3.57042475
49	centriole replication (GO:0007099)	3.46261136
50	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.45202836
51	response to acidic pH (GO:0010447)	3.44740060
52	seminiferous tubule development (GO:0072520)	3.43232527
53	cilium morphogenesis (GO:0060271)	3.43080652
54	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	3.38146334
55	relaxation of smooth muscle (GO:0044557)	3.34604026
56	negative regulation of viral release from host cell (GO:1902187)	3.34580177
57	fertilization (GO:0009566)	3.33442103
58	DNA double-strand break processing (GO:0000729)	3.32733727
59	phosphatidylserine metabolic process (GO:0006658)	3.32234711
60	ketone body metabolic process (GO:1902224)	3.31257864
61	centriole assembly (GO:0098534)	3.24261463
62	cellular response to pH (GO:0071467)	3.23208762
63	male sex determination (GO:0030238)	3.21010281
64	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.20325294
65	histone exchange (GO:0043486)	3.16260453
66	germ cell development (GO:0007281)	3.14609188
67	single strand break repair (GO:0000012)	3.13124986
68	calcium ion-dependent exocytosis (GO:0017156)	3.12083807
69	plasma membrane fusion (GO:0045026)	3.10102122
70	positive regulation of meiotic cell cycle (GO:0051446)	3.09384502
71	positive regulation of meiosis (GO:0045836)	2.97938817
72	regulation of oxidative phosphorylation (GO:0002082)	2.92040255
73	cellular biogenic amine biosynthetic process (GO:0042401)	2.90726816
74	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.89002966
75	ATP synthesis coupled proton transport (GO:0015986)	2.89002966
76	RNA destabilization (GO:0050779)	2.87622324
77	male gamete generation (GO:0048232)	2.87238229
78	amine biosynthetic process (GO:0009309)	2.84923927
79	proteasome assembly (GO:0043248)	2.84156931
80	spermatogenesis (GO:0007283)	2.83700834
81	indolalkylamine metabolic process (GO:0006586)	2.81397565
82	S-adenosylmethionine metabolic process (GO:0046500)	2.80033427
83	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.78296220
84	polyamine biosynthetic process (GO:0006596)	2.70595945
85	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.69801356
86	microtubule depolymerization (GO:0007019)	2.69062908
87	smoothened signaling pathway (GO:0007224)	2.67661878
88	cilium organization (GO:0044782)	2.66833913
89	gamete generation (GO:0007276)	2.66377370
90	Leydig cell differentiation (GO:0033327)	2.65419547
91	tryptophan catabolic process (GO:0006569)	2.64469743
92	indole-containing compound catabolic process (GO:0042436)	2.64469743
93	indolalkylamine catabolic process (GO:0046218)	2.64469743
94	regulation of oxidative stress-induced neuron death (GO:1903203)	2.62908881
95	oogenesis (GO:0048477)	2.62897561
96	activation of protein kinase B activity (GO:0032148)	2.61971787
97	cilium assembly (GO:0042384)	2.61454758
98	platelet dense granule organization (GO:0060155)	2.60114594
99	protein neddylation (GO:0045116)	2.59694781
100	positive regulation of glycolytic process (GO:0045821)	2.58243366

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	6.49662613
2	IGF1R_20145208_ChIP-Seq_DFB_Human	4.61757406
3	VDR_22108803_ChIP-Seq_LS180_Human	2.99013047
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.87918368
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.82685629
6	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.68361247
7	FUS_26573619_Chip-Seq_HEK293_Human	2.63727216
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.55388255
9	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.48748436
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.46352747
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.44752667
12	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.24180790
13	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.20972097
14	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.14613415
15	P300_19829295_ChIP-Seq_ESCs_Human	2.04642687
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.97110096
17	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.94032937
18	CBP_20019798_ChIP-Seq_JUKART_Human	1.94032937
19	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.93945803
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.92982534
21	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.90182332
22	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.85589711
23	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.85589711
24	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.81860480
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.80193840
26	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.71710552
27	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.70177772
28	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.68891658
29	EWS_26573619_Chip-Seq_HEK293_Human	1.66703555
30	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.66228308
31	AR_25329375_ChIP-Seq_VCAP_Human	1.62222029
32	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.56961385
33	CDX2_22108803_ChIP-Seq_LS180_Human	1.55079064
34	BCAT_22108803_ChIP-Seq_LS180_Human	1.51026260
35	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.49503430
36	ERA_21632823_ChIP-Seq_H3396_Human	1.48948777
37	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.48675186
38	SOX2_19829295_ChIP-Seq_ESCs_Human	1.46669751
39	NANOG_19829295_ChIP-Seq_ESCs_Human	1.46669751
40	NANOG_20526341_ChIP-Seq_ESCs_Human	1.44512408
41	HOXB7_26014856_ChIP-Seq_BT474_Human	1.42205378
42	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.41452919
43	MYC_19829295_ChIP-Seq_ESCs_Human	1.41069373
44	SMAD4_21799915_ChIP-Seq_A2780_Human	1.40551407
45	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.35986605
46	TCF4_22108803_ChIP-Seq_LS180_Human	1.34526164
47	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.34475496
48	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.34051840
49	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.32676676
50	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.31854410
51	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.31491301
52	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.30280214
53	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.28975428
54	PHF8_20622853_ChIP-Seq_HELA_Human	1.28222985
55	ELK1_19687146_ChIP-ChIP_HELA_Human	1.28016791
56	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.27749879
57	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.27301396
58	TAF15_26573619_Chip-Seq_HEK293_Human	1.26137063
59	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.25764868
60	TBL1_22424771_ChIP-Seq_293T_Human	1.24231594
61	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.23164172
62	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.22973665
63	MYC_18940864_ChIP-ChIP_HL60_Human	1.21952515
64	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.21742739
65	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.20918964
66	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.20366938
67	TP53_22573176_ChIP-Seq_HFKS_Human	1.19070450
68	TCF4_23295773_ChIP-Seq_U87_Human	1.14433917
69	RBPJ_21746931_ChIP-Seq_IB4_Human	1.13953071
70	ETV1_20927104_ChIP-Seq_GIST48_Human	1.13426896
71	STAT3_23295773_ChIP-Seq_U87_Human	1.13311591
72	NFYB_21822215_ChIP-Seq_K562_Human	1.12966281
73	TP53_18474530_ChIP-ChIP_U2OS_Human	1.12344808
74	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.11877345
75	RUNX2_22187159_ChIP-Seq_PCA_Human	1.11761752
76	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.11396325
77	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.09562689
78	AR_20517297_ChIP-Seq_VCAP_Human	1.09377087
79	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.09114789
80	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08997588
81	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.06424975
82	NFYA_21822215_ChIP-Seq_K562_Human	1.05978711
83	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.05881620
84	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.05858313
85	NCOR_22424771_ChIP-Seq_293T_Human	1.05421695
86	EZH2_22144423_ChIP-Seq_EOC_Human	1.04592615
87	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.03614979
88	IRF1_19129219_ChIP-ChIP_H3396_Human	1.02964208
89	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.02913210
90	VDR_23849224_ChIP-Seq_CD4+_Human	1.00946163
91	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.00300465
92	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.00222186
93	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.99912183
94	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.99554813
95	AR_21572438_ChIP-Seq_LNCaP_Human	0.98874320
96	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.98284934
97	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.98182720
98	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.97977406
99	ERG_20517297_ChIP-Seq_VCAP_Human	0.97892239
100	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95785031

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	6.04718391
2	MP0002138_abnormal_hepatobiliary_system	3.50673481
3	MP0006054_spinal_hemorrhage	3.38837315
4	MP0002160_abnormal_reproductive_system	2.95964626
5	MP0003315_abnormal_perineum_morphology	2.86315096
6	MP0005360_urolithiasis	2.84583235
7	MP0002254_reproductive_system_inflammat	2.47920078
8	MP0010386_abnormal_urinary_bladder	2.42655574
9	MP0003698_abnormal_male_reproductive	2.37612891
10	MP0005646_abnormal_pituitary_gland	2.26842105
11	MP0006072_abnormal_retinal_apoptosis	2.21647522
12	MP0001929_abnormal_gametogenesis	2.20672029
13	MP0002837_dystrophic_cardiac_calcinosis	2.19128296
14	MP0008004_abnormal_stomach_pH	2.18397489
15	MP0003136_yellow_coat_color	2.15553685
16	MP0001984_abnormal_olfaction	2.10699172
17	MP0004145_abnormal_muscle_electrophysio	2.06053469
18	MP0003195_calcinosis	1.95629284
19	MP0001486_abnormal_startle_reflex	1.90083176
20	MP0002102_abnormal_ear_morphology	1.87899515
21	MP0005174_abnormal_tail_pigmentation	1.76711830
22	MP0005389_reproductive_system_phenotype	1.72768094
23	MP0002653_abnormal_ependyma_morphology	1.71520459
24	MP0005253_abnormal_eye_physiology	1.68155560
25	MP0005171_absent_coat_pigmentation	1.66788209
26	MP0008877_abnormal_DNA_methylation	1.66582084
27	MP0005551_abnormal_eye_electrophysiolog	1.66375038
28	MP0006036_abnormal_mitochondrial_physio	1.57759720
29	MP0001188_hyperpigmentation	1.50845624
30	MP0001485_abnormal_pinna_reflex	1.50683620
31	MP0001905_abnormal_dopamine_level	1.49558657
32	MP0002210_abnormal_sex_determination	1.47655433
33	MP0003806_abnormal_nucleotide_metabolis	1.42284062
34	MP0000631_abnormal_neuroendocrine_gland	1.40797401
35	MP0009697_abnormal_copulation	1.38434740
36	MP0001727_abnormal_embryo_implantation	1.37517105
37	MP0003718_maternal_effect	1.36305908
38	MP0002277_abnormal_respiratory_mucosa	1.36150356
39	MP0003011_delayed_dark_adaptation	1.36115972
40	MP0002132_abnormal_respiratory_system	1.35444919
41	MP0000372_irregular_coat_pigmentation	1.30926146
42	MP0001145_abnormal_male_reproductive	1.30002530
43	MP0005647_abnormal_sex_gland	1.29509315
44	MP0000749_muscle_degeneration	1.28940644
45	MP0000653_abnormal_sex_gland	1.27613034
46	MP0000538_abnormal_urinary_bladder	1.24938150
47	MP0005248_abnormal_Harderian_gland	1.22494181
48	MP0001968_abnormal_touch/_nociception	1.22489415
49	MP0005187_abnormal_penis_morphology	1.20246699
50	MP0002090_abnormal_vision	1.17336513
51	MP0002282_abnormal_trachea_morphology	1.17094691
52	MP0002161_abnormal_fertility/fecundity	1.16556308
53	MP0009046_muscle_twitch	1.15780142
54	MP0008995_early_reproductive_senescence	1.15538725
55	MP0001764_abnormal_homeostasis	1.12684798
56	MP0001501_abnormal_sleep_pattern	1.09891398
57	MP0001919_abnormal_reproductive_system	1.09891171
58	MP0002736_abnormal_nociception_after	1.05424430
59	MP0003880_abnormal_central_pattern	1.04518243
60	MP0000613_abnormal_salivary_gland	1.04218511
61	MP0003786_premature_aging	1.02323518
62	MP0004085_abnormal_heartbeat	1.00167004
63	MP0005367_renal/urinary_system_phenotyp	0.97884560
64	MP0000516_abnormal_urinary_system	0.97884560
65	MP0009745_abnormal_behavioral_response	0.97837387
66	MP0005084_abnormal_gallbladder_morpholo	0.95432842
67	MP0008872_abnormal_physiological_respon	0.94720929
68	MP0002638_abnormal_pupillary_reflex	0.93463010
69	MP0002938_white_spotting	0.92838043
70	MP0004742_abnormal_vestibular_system	0.91035188
71	MP0003936_abnormal_reproductive_system	0.90929642
72	MP0003878_abnormal_ear_physiology	0.90878739
73	MP0005377_hearing/vestibular/ear_phenot	0.90878739
74	MP0003045_fibrosis	0.90550352
75	MP0002272_abnormal_nervous_system	0.89490291
76	MP0006276_abnormal_autonomic_nervous	0.88507842
77	MP0003137_abnormal_impulse_conducting	0.84381058
78	MP0005499_abnormal_olfactory_system	0.80633503
79	MP0005394_taste/olfaction_phenotype	0.80633503
80	MP0000026_abnormal_inner_ear	0.80238387
81	MP0004134_abnormal_chest_morphology	0.79806765
82	MP0004381_abnormal_hair_follicle	0.78388991
83	MP0000049_abnormal_middle_ear	0.78228243
84	MP0002752_abnormal_somatic_nervous	0.77810270
85	MP0003633_abnormal_nervous_system	0.76943843
86	MP0005075_abnormal_melanosome_morpholog	0.76074216
87	MP0001119_abnormal_female_reproductive	0.75958647
88	MP0009250_abnormal_appendicular_skeleto	0.75870868
89	MP0008058_abnormal_DNA_repair	0.75797974
90	MP0003646_muscle_fatigue	0.74988495
91	MP0001963_abnormal_hearing_physiology	0.74287867
92	MP0006292_abnormal_olfactory_placode	0.74283068
93	MP0005085_abnormal_gallbladder_physiolo	0.73407142
94	MP0000647_abnormal_sebaceous_gland	0.73010905
95	MP0002229_neurodegeneration	0.69251902
96	MP0005395_other_phenotype	0.67037612
97	MP0002184_abnormal_innervation	0.66685039
98	MP0005391_vision/eye_phenotype	0.66228710
99	MP0005595_abnormal_vascular_smooth	0.65587754
100	MP0003567_abnormal_fetal_cardiomyocyte	0.65071504

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Agnosia (HP:0010524)	8.02485439
2	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	7.79266439
3	Disinhibition (HP:0000734)	5.30501216
4	Axonal loss (HP:0003447)	4.95530664
5	Hypoplasia of the uterus (HP:0000013)	4.54661140
6	Absent/shortened dynein arms (HP:0200106)	4.16204041
7	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.16204041
8	Progressive external ophthalmoplegia (HP:0000590)	3.97432672
9	Aplasia/hypoplasia of the uterus (HP:0008684)	3.87688245
10	Inappropriate behavior (HP:0000719)	3.69830370
11	Abnormal ciliary motility (HP:0012262)	3.47416928
12	True hermaphroditism (HP:0010459)	3.40464595
13	Pancreatic cysts (HP:0001737)	3.30585307
14	Chronic hepatic failure (HP:0100626)	3.27703515
15	Male pseudohermaphroditism (HP:0000037)	3.25089193
16	Neck muscle weakness (HP:0000467)	3.22881920
17	Pancreatic fibrosis (HP:0100732)	3.21468824
18	Abnormal respiratory motile cilium physiology (HP:0012261)	3.18196493
19	Abnormal respiratory motile cilium morphology (HP:0005938)	3.10991277
20	Abnormal respiratory epithelium morphology (HP:0012253)	3.10991277
21	Upper motor neuron abnormality (HP:0002127)	3.08847850
22	Personality changes (HP:0000751)	3.04413909
23	Sex reversal (HP:0012245)	2.97280516
24	Abnormal sex determination (HP:0012244)	2.97280516
25	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.94914358
26	Absent thumb (HP:0009777)	2.92766547
27	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.83925428
28	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.83925428
29	Occipital encephalocele (HP:0002085)	2.67642451
30	Type II lissencephaly (HP:0007260)	2.63521620
31	Mask-like facies (HP:0000298)	2.58617352
32	Bone cyst (HP:0012062)	2.56698977
33	Abnormality of midbrain morphology (HP:0002418)	2.51338086
34	Molar tooth sign on MRI (HP:0002419)	2.51338086
35	Hypothermia (HP:0002045)	2.50866422
36	Generalized aminoaciduria (HP:0002909)	2.44635130
37	Attenuation of retinal blood vessels (HP:0007843)	2.42908642
38	Lipid accumulation in hepatocytes (HP:0006561)	2.42343012
39	Acute necrotizing encephalopathy (HP:0006965)	2.41140815
40	Bile duct proliferation (HP:0001408)	2.36794260
41	Abnormal biliary tract physiology (HP:0012439)	2.36794260
42	Gonadal dysgenesis (HP:0000133)	2.35926485
43	Abnormal rod and cone electroretinograms (HP:0008323)	2.26201109
44	Nephronophthisis (HP:0000090)	2.26145129
45	Polyphagia (HP:0002591)	2.24994509
46	Progressive macrocephaly (HP:0004481)	2.24481379
47	Abnormality of the renal cortex (HP:0011035)	2.21194912
48	Sclerocornea (HP:0000647)	2.20851242
49	Cystic liver disease (HP:0006706)	2.19513564
50	Reduced antithrombin III activity (HP:0001976)	2.17984364
51	Infertility (HP:0000789)	2.15955841
52	Glycosuria (HP:0003076)	2.15829371
53	Abnormality of urine glucose concentration (HP:0011016)	2.15829371
54	Renal cortical cysts (HP:0000803)	2.15505214
55	Oculomotor apraxia (HP:0000657)	2.13156764
56	Resting tremor (HP:0002322)	2.11108211
57	Congenital sensorineural hearing impairment (HP:0008527)	2.10845380
58	Mitochondrial inheritance (HP:0001427)	2.10374427
59	Amyotrophic lateral sclerosis (HP:0007354)	2.10041562
60	Sensory axonal neuropathy (HP:0003390)	2.09942953
61	Renal Fanconi syndrome (HP:0001994)	2.09166632
62	Cerebellar dysplasia (HP:0007033)	2.08908462
63	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.06458552
64	Acute encephalopathy (HP:0006846)	2.05450044
65	Abnormality of macular pigmentation (HP:0008002)	2.05250142
66	Syncope (HP:0001279)	2.02194755
67	Abnormal drinking behavior (HP:0030082)	2.01437728
68	Polydipsia (HP:0001959)	2.01437728
69	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.00922776
70	Abnormality of the renal medulla (HP:0100957)	1.99434594
71	Anencephaly (HP:0002323)	1.98083321
72	Median cleft lip (HP:0000161)	1.97845630
73	Poor head control (HP:0002421)	1.97823721
74	Abnormality of the ileum (HP:0001549)	1.97465526
75	Tubulointerstitial nephritis (HP:0001970)	1.96986572
76	Abnormal mitochondria in muscle tissue (HP:0008316)	1.95508087
77	Facial hemangioma (HP:0000329)	1.95406982
78	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.93719451
79	3-Methylglutaconic aciduria (HP:0003535)	1.89261192
80	Retinal dysplasia (HP:0007973)	1.88689279
81	Congenital, generalized hypertrichosis (HP:0004540)	1.87623955
82	Meckel diverticulum (HP:0002245)	1.84740716
83	Hypoglycemic coma (HP:0001325)	1.84496328
84	Multiple enchondromatosis (HP:0005701)	1.83891043
85	Rhinitis (HP:0012384)	1.83880885
86	Increased CSF lactate (HP:0002490)	1.82174575
87	Abnormality of the columella (HP:0009929)	1.80895461
88	Basal ganglia calcification (HP:0002135)	1.77651634
89	Increased hepatocellular lipid droplets (HP:0006565)	1.76229730
90	Hepatic necrosis (HP:0002605)	1.75568228
91	Facial cleft (HP:0002006)	1.74851871
92	Cerebral edema (HP:0002181)	1.74587703
93	Aqueductal stenosis (HP:0002410)	1.72672851
94	Spastic paraparesis (HP:0002313)	1.71459867
95	Bony spicule pigmentary retinopathy (HP:0007737)	1.69234272
96	Severe visual impairment (HP:0001141)	1.66541818
97	Optic disc pallor (HP:0000543)	1.66441991
98	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.66055102
99	Abnormality of the basal ganglia (HP:0002134)	1.65726090
100	Abnormality of the motor neurons (HP:0002450)	1.65321773

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	6.96718094
2	EIF2AK1	3.66153012
3	MARK3	3.37033148
4	FRK	3.25514015
5	ZAK	2.74828624
6	MAP4K2	2.53598183
7	TLK1	2.34590362
8	BCKDK	2.28835721
9	NEK2	2.03308923
10	PLK4	2.02745377
11	STK38L	1.92876870
12	SCYL2	1.92771585
13	CSNK1G3	1.91089468
14	INSRR	1.79264072
15	BMPR1B	1.78060887
16	MYLK	1.73637496
17	MAP3K4	1.73396804
18	CSNK1G1	1.72340725
19	WNK3	1.69101570
20	CSNK1A1L	1.62101633
21	RPS6KA5	1.54597170
22	CSNK1G2	1.52811556
23	LATS1	1.44599432
24	VRK1	1.43875429
25	GRK1	1.43746244
26	MAPKAPK3	1.43276573
27	MAP2K7	1.42002220
28	TRIM28	1.39615202
29	OBSCN	1.35427661
30	NUAK1	1.23509952
31	PTK2B	1.19011824
32	ADRBK2	1.15508178
33	DYRK2	1.11290937
34	EIF2AK3	1.10356759
35	STK39	1.09533811
36	PNCK	1.07283471
37	MST4	1.04428715
38	PLK2	1.02961786
39	ACVR1B	1.02646078
40	MAPK13	1.01226861
41	PRKCQ	0.97061924
42	MAPK15	0.96659506
43	STK16	0.93780282
44	OXSR1	0.92554125
45	DYRK3	0.88823683
46	CDK3	0.87173762
47	MAPKAPK5	0.86651740
48	TNIK	0.84973995
49	TRPM7	0.84678906
50	DYRK1A	0.83437142
51	CASK	0.78860847
52	PHKG2	0.75765111
53	PHKG1	0.75765111
54	WNK4	0.73426592
55	FGFR2	0.71480700
56	TIE1	0.64615310
57	SGK494	0.64445196
58	SGK223	0.64445196
59	PLK3	0.61200434
60	MAP3K1	0.61008897
61	MUSK	0.58711183
62	MAP2K6	0.58149105
63	WEE1	0.53975034
64	FGFR1	0.53928356
65	CSNK1D	0.51788504
66	EPHA4	0.49461911
67	PAK3	0.49174297
68	EEF2K	0.48663954
69	BRSK2	0.47916237
70	RPS6KB2	0.47799266
71	PRKG1	0.47703848
72	TGFBR1	0.46698235
73	PRKCE	0.46470913
74	BUB1	0.44093501
75	CDK14	0.41204863
76	PLK1	0.39422303
77	STK38	0.36884231
78	SYK	0.36130666
79	STK3	0.35132241
80	CSNK1A1	0.35087777
81	MKNK2	0.33649166
82	PIK3CG	0.33420701
83	PRKCG	0.32710541
84	PKN1	0.32019969
85	AKT3	0.30883010
86	ADRBK1	0.29563858
87	PRKACA	0.29356977
88	ATM	0.28906427
89	NLK	0.28463361
90	CSNK2A1	0.28307817
91	NME1	0.27650504
92	PIK3CA	0.27296277
93	PRKG2	0.26780299
94	PBK	0.26756920
95	CSNK2A2	0.26077985
96	RPS6KB1	0.24569467
97	PDK2	0.23702089
98	ROCK1	0.22511395
99	SRPK1	0.22228385
100	VRK2	0.21887007

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	4.11446224
2	Linoleic acid metabolism_Homo sapiens_hsa00591	3.93096316
3	Nitrogen metabolism_Homo sapiens_hsa00910	3.54910927
4	Sulfur relay system_Homo sapiens_hsa04122	3.03080572
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.68117445
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.38043000
7	Parkinsons disease_Homo sapiens_hsa05012	2.36238256
8	Ether lipid metabolism_Homo sapiens_hsa00565	2.25432684
9	Propanoate metabolism_Homo sapiens_hsa00640	2.22891457
10	RNA polymerase_Homo sapiens_hsa03020	2.21520087
11	mRNA surveillance pathway_Homo sapiens_hsa03015	1.85100019
12	Butanoate metabolism_Homo sapiens_hsa00650	1.81400166
13	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.80443895
14	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.77621620
15	Olfactory transduction_Homo sapiens_hsa04740	1.69579548
16	Phototransduction_Homo sapiens_hsa04744	1.69190970
17	Ribosome_Homo sapiens_hsa03010	1.69017706
18	Protein export_Homo sapiens_hsa03060	1.63912999
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.62803538
20	Chemical carcinogenesis_Homo sapiens_hsa05204	1.60797934
21	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.58697983
22	Huntingtons disease_Homo sapiens_hsa05016	1.54502095
23	Alzheimers disease_Homo sapiens_hsa05010	1.47740286
24	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.47295953
25	Proteasome_Homo sapiens_hsa03050	1.45667601
26	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.43838180
27	RNA transport_Homo sapiens_hsa03013	1.41238264
28	Sulfur metabolism_Homo sapiens_hsa00920	1.35653098
29	Gap junction_Homo sapiens_hsa04540	1.29163325
30	Basal transcription factors_Homo sapiens_hsa03022	1.23610185
31	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.20702564
32	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.16938480
33	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.16475997
34	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.14454596
35	Glutathione metabolism_Homo sapiens_hsa00480	1.13901719
36	Regulation of autophagy_Homo sapiens_hsa04140	1.10192599
37	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.09106877
38	Tryptophan metabolism_Homo sapiens_hsa00380	1.09007701
39	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.07368403
40	RNA degradation_Homo sapiens_hsa03018	1.05132861
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.04427635
42	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.01494235
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.00028209
44	Circadian rhythm_Homo sapiens_hsa04710	0.98455159
45	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.94929964
46	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.94089611
47	Folate biosynthesis_Homo sapiens_hsa00790	0.93847404
48	Cardiac muscle contraction_Homo sapiens_hsa04260	0.93122242
49	Collecting duct acid secretion_Homo sapiens_hsa04966	0.92772296
50	Purine metabolism_Homo sapiens_hsa00230	0.92225055
51	Homologous recombination_Homo sapiens_hsa03440	0.91144120
52	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.82919053
53	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.82337309
54	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.82036995
55	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.79075930
56	Taste transduction_Homo sapiens_hsa04742	0.77304320
57	Pyruvate metabolism_Homo sapiens_hsa00620	0.77278410
58	beta-Alanine metabolism_Homo sapiens_hsa00410	0.75400675
59	Pyrimidine metabolism_Homo sapiens_hsa00240	0.70766900
60	Metabolic pathways_Homo sapiens_hsa01100	0.69682308
61	Type I diabetes mellitus_Homo sapiens_hsa04940	0.69209237
62	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.69100953
63	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.68536179
64	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.68080512
65	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.66709813
66	Allograft rejection_Homo sapiens_hsa05330	0.66550289
67	Retinol metabolism_Homo sapiens_hsa00830	0.66127260
68	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.64900651
69	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.64070802
70	Graft-versus-host disease_Homo sapiens_hsa05332	0.63236474
71	Alcoholism_Homo sapiens_hsa05034	0.62909860
72	Nucleotide excision repair_Homo sapiens_hsa03420	0.62745382
73	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.61667610
74	Selenocompound metabolism_Homo sapiens_hsa00450	0.61320180
75	Arginine biosynthesis_Homo sapiens_hsa00220	0.60918411
76	Oocyte meiosis_Homo sapiens_hsa04114	0.59643024
77	Phagosome_Homo sapiens_hsa04145	0.58884941
78	Nicotine addiction_Homo sapiens_hsa05033	0.57023837
79	Peroxisome_Homo sapiens_hsa04146	0.56768986
80	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.56374322
81	Fatty acid degradation_Homo sapiens_hsa00071	0.55819120
82	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.54962831
83	Caffeine metabolism_Homo sapiens_hsa00232	0.53235433
84	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.53114978
85	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.51122960
86	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.48200997
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.43440734
88	Tyrosine metabolism_Homo sapiens_hsa00350	0.41237115
89	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.40689355
90	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.40186583
91	Fat digestion and absorption_Homo sapiens_hsa04975	0.39072338
92	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.35237146
93	Fatty acid metabolism_Homo sapiens_hsa01212	0.35222352
94	Phenylalanine metabolism_Homo sapiens_hsa00360	0.35067358
95	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.32238242
96	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.31782717
97	Rheumatoid arthritis_Homo sapiens_hsa05323	0.28531628
98	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.25225419
99	PPAR signaling pathway_Homo sapiens_hsa03320	0.24910166
100	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.24252808

SPTY2D1-AS1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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