SPX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a hormone involved in modulation of cardiovascular and renal function. It has also been shown in rats to cause weight loss. Several transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)7.70977037
2protein neddylation (GO:0045116)7.68827758
3regulation of platelet activation (GO:0010543)6.71613674
4neutrophil activation involved in immune response (GO:0002283)6.56208907
5daunorubicin metabolic process (GO:0044597)6.47535637
6polyketide metabolic process (GO:0030638)6.47535637
7doxorubicin metabolic process (GO:0044598)6.47535637
8adenosine receptor signaling pathway (GO:0001973)5.94573099
9blood coagulation, intrinsic pathway (GO:0007597)5.88447445
10platelet aggregation (GO:0070527)5.62387406
11negative regulation of norepinephrine secretion (GO:0010700)5.62167841
12negative regulation of platelet activation (GO:0010544)5.55348387
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.51443571
14negative regulation of synaptic transmission, GABAergic (GO:0032229)5.10623420
15regulation of integrin-mediated signaling pathway (GO:2001044)5.03318771
16negative regulation of thymocyte apoptotic process (GO:0070244)4.98686063
17positive regulation of endothelial cell differentiation (GO:0045603)4.93825311
18presynaptic membrane assembly (GO:0097105)4.92640732
19leukocyte migration involved in inflammatory response (GO:0002523)4.87794374
20lipoxygenase pathway (GO:0019372)4.80419536
21startle response (GO:0001964)4.80121187
22negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.73894813
23regulation of integrin activation (GO:0033623)4.59335917
24platelet degranulation (GO:0002576)4.50547613
25presynaptic membrane organization (GO:0097090)4.47414011
26G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.46357859
27regulation of lipoprotein metabolic process (GO:0050746)4.42170607
28angiogenesis involved in wound healing (GO:0060055)4.38307092
29response to pheromone (GO:0019236)4.37809796
30regulation of homotypic cell-cell adhesion (GO:0034110)4.36068297
31negative regulation of protein localization to cell surface (GO:2000009)4.23324685
32serotonin receptor signaling pathway (GO:0007210)4.22442411
33polyamine biosynthetic process (GO:0006596)4.20174155
34low-density lipoprotein particle remodeling (GO:0034374)4.16788977
35positive regulation of mast cell activation (GO:0033005)4.14591976
36positive regulation of hemostasis (GO:1900048)4.01518994
37positive regulation of blood coagulation (GO:0030194)4.01518994
38positive regulation of cAMP-mediated signaling (GO:0043950)3.97000013
39platelet activation (GO:0030168)3.96801156
40positive regulation of macrophage differentiation (GO:0045651)3.94921613
41purinergic nucleotide receptor signaling pathway (GO:0035590)3.93889119
42mesenchymal cell differentiation involved in kidney development (GO:0072161)3.92579192
43mesenchymal cell differentiation involved in renal system development (GO:2001012)3.92579192
44neuron cell-cell adhesion (GO:0007158)3.92563191
45regulation of Golgi to plasma membrane protein transport (GO:0042996)3.89029039
46aminoglycoside antibiotic metabolic process (GO:0030647)3.88080126
47fusion of sperm to egg plasma membrane (GO:0007342)3.86628651
48postsynaptic membrane organization (GO:0001941)3.81533127
49positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.78860459
50homotypic cell-cell adhesion (GO:0034109)3.77049384
51megakaryocyte development (GO:0035855)3.75945650
52regulation of macrophage derived foam cell differentiation (GO:0010743)3.74464241
53positive regulation of Rho protein signal transduction (GO:0035025)3.70652926
54negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.69388699
55cerebral cortex radially oriented cell migration (GO:0021799)3.68668059
56regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.68102519
57relaxation of smooth muscle (GO:0044557)3.64781319
58long-chain fatty acid biosynthetic process (GO:0042759)3.62816401
59positive regulation of receptor recycling (GO:0001921)3.62758825
60synaptic transmission, glutamatergic (GO:0035249)3.60844429
61platelet formation (GO:0030220)3.59411119
62regulation of norepinephrine secretion (GO:0014061)3.59108429
63ionotropic glutamate receptor signaling pathway (GO:0035235)3.59029764
64inner ear receptor stereocilium organization (GO:0060122)3.58952491
65regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.58936139
66negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.58899620
67positive regulation of coagulation (GO:0050820)3.57812578
68neutrophil activation (GO:0042119)3.56737225
69G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.53859614
70negative regulation of catecholamine secretion (GO:0033604)3.52278087
71purinergic receptor signaling pathway (GO:0035587)3.45340807
72extracellular fibril organization (GO:0043206)3.45186592
73auditory receptor cell stereocilium organization (GO:0060088)3.44423930
74beta-amyloid metabolic process (GO:0050435)3.43932345
75vocalization behavior (GO:0071625)3.38339401
76negative regulation of neurotransmitter transport (GO:0051589)3.36633695
77regulation of endothelial cell differentiation (GO:0045601)3.36524970
78drinking behavior (GO:0042756)3.35771603
79extracellular regulation of signal transduction (GO:1900115)3.32056442
80extracellular negative regulation of signal transduction (GO:1900116)3.32056442
81negative regulation of mast cell activation (GO:0033004)3.30746664
82regulation of inositol phosphate biosynthetic process (GO:0010919)3.30304077
83negative regulation of muscle contraction (GO:0045932)3.30184469
84regulation of cAMP-dependent protein kinase activity (GO:2000479)3.29953081
85opioid receptor signaling pathway (GO:0038003)3.28964181
86negative regulation of neural precursor cell proliferation (GO:2000178)3.28432642
87urinary tract smooth muscle contraction (GO:0014848)3.26955763
88regulation of MHC class II biosynthetic process (GO:0045346)3.26613783
89regulation of blood coagulation (GO:0030193)3.23364362
90regulation of hemostasis (GO:1900046)3.23364362
91cell differentiation involved in metanephros development (GO:0072202)3.21887882
92negative regulation of T cell apoptotic process (GO:0070233)3.21500219
93dopamine transport (GO:0015872)3.19651107
94relaxation of muscle (GO:0090075)3.19540297
95phospholipid homeostasis (GO:0055091)3.17475152
96detection of molecule of bacterial origin (GO:0032490)3.15508561
97neuron-neuron synaptic transmission (GO:0007270)3.15240673
98activation of protein kinase A activity (GO:0034199)3.14543711
99termination of G-protein coupled receptor signaling pathway (GO:0038032)3.12294416
100cyclooxygenase pathway (GO:0019371)3.11278813
101nonmotile primary cilium assembly (GO:0035058)3.10907926
102negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.10650022
103granulocyte activation (GO:0036230)3.09855051
104regulation of female receptivity (GO:0045924)3.09809757
105negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.08368164
106regulation of glutamate receptor signaling pathway (GO:1900449)3.07624416
107positive regulation of heat generation (GO:0031652)3.07368135
108sleep (GO:0030431)3.06080817
109glutamate receptor signaling pathway (GO:0007215)3.04194727
110regulation of receptor recycling (GO:0001919)3.01922463
111termination of signal transduction (GO:0023021)3.01844425
112cellular biogenic amine biosynthetic process (GO:0042401)2.99089721
113high-density lipoprotein particle remodeling (GO:0034375)2.98444310
114negative regulation of calcium ion transmembrane transport (GO:1903170)2.97892231
115negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.97892231
116synaptic vesicle docking involved in exocytosis (GO:0016081)2.97256871
117mitochondrial calcium ion transport (GO:0006851)2.97031912
118positive regulation of synapse assembly (GO:0051965)2.96174102
119regulation of cholesterol efflux (GO:0010874)2.95919718
120energy homeostasis (GO:0097009)2.94078477
121erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.94077114
122L-phenylalanine catabolic process (GO:0006559)2.94077114
123negative regulation of stress fiber assembly (GO:0051497)2.92638700
124kidney morphogenesis (GO:0060993)2.92071621
125regulation of coagulation (GO:0050818)2.90528320
126reverse cholesterol transport (GO:0043691)2.89847722
127protoporphyrinogen IX biosynthetic process (GO:0006782)2.88615808
128positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.88291080
129regulation of fever generation (GO:0031620)2.86533956
130histone H3-K4 trimethylation (GO:0080182)2.85799076
131aggressive behavior (GO:0002118)2.85543906
132plasma membrane fusion (GO:0045026)2.85378189
133autophagic vacuole fusion (GO:0000046)2.83514803
134cell differentiation involved in kidney development (GO:0061005)2.83065019
135reflex (GO:0060004)2.81730314
136negative regulation of calcium ion transport into cytosol (GO:0010523)2.80776441
137regulation of memory T cell differentiation (GO:0043380)2.79641083
138regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.79506493
139amine biosynthetic process (GO:0009309)2.78762824
140cardiolipin metabolic process (GO:0032048)2.78341869
141vesicle targeting (GO:0006903)2.78122348
142dentate gyrus development (GO:0021542)2.77092583
143monoamine transport (GO:0015844)2.76858366
144regulation of synapse maturation (GO:0090128)2.76761191
145fibril organization (GO:0097435)2.76108609
146skeletal muscle tissue regeneration (GO:0043403)2.75432172
147positive regulation of cardiac muscle hypertrophy (GO:0010613)2.75006970
148positive regulation of muscle hypertrophy (GO:0014742)2.75006970
149positive regulation of uterine smooth muscle contraction (GO:0070474)2.71603828
150regulation of DNA endoreduplication (GO:0032875)2.68511672
151neurotransmitter-gated ion channel clustering (GO:0072578)2.68498852
152mannosylation (GO:0097502)2.68411869
153mechanosensory behavior (GO:0007638)2.67811633
154sequestering of extracellular ligand from receptor (GO:0035581)2.66225775
155neuronal action potential propagation (GO:0019227)2.64311474
156cytochrome complex assembly (GO:0017004)2.62867981
157regulation of timing of cell differentiation (GO:0048505)2.60658955
158negative regulation of homotypic cell-cell adhesion (GO:0034111)2.60320417
159gamma-aminobutyric acid signaling pathway (GO:0007214)2.60219297
160forebrain neuron differentiation (GO:0021879)2.59237142
161regulation of synaptic transmission, GABAergic (GO:0032228)2.59208776
162positive regulation of action potential (GO:0045760)2.58753887
163prostate gland growth (GO:0060736)2.58234880
164DNA strand renaturation (GO:0000733)2.57843342
165positive regulation of cellular amide metabolic process (GO:0034250)2.57047012
166mesenchymal cell differentiation (GO:0048762)2.56930394
167negative regulation of stem cell proliferation (GO:2000647)2.56738495
168superoxide anion generation (GO:0042554)2.56454822
169negative regulation of systemic arterial blood pressure (GO:0003085)2.53269220
170regulation of respiratory system process (GO:0044065)2.52860040
171phagosome maturation (GO:0090382)2.52638926
172developmental pigmentation (GO:0048066)2.52374147
173righting reflex (GO:0060013)2.51379698
174detection of calcium ion (GO:0005513)2.51270464
175protein localization to cilium (GO:0061512)2.50003541
176cellular anion homeostasis (GO:0030002)2.49510983
177response to cocaine (GO:0042220)2.48997612
178G-protein coupled receptor internalization (GO:0002031)2.48224756
179response to auditory stimulus (GO:0010996)2.47916348
180regulation of synaptic transmission, glutamatergic (GO:0051966)2.46615467
181substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.46571213
182substrate-independent telencephalic tangential migration (GO:0021826)2.46571213
183G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.44971857
184cranial nerve structural organization (GO:0021604)2.44568641
185limb bud formation (GO:0060174)2.42817224
186negative regulation of T cell mediated immunity (GO:0002710)2.40935435
187regulation of synapse assembly (GO:0051963)2.38462637
188regulation of activation of Janus kinase activity (GO:0010533)2.36627906
189regulation of platelet aggregation (GO:0090330)2.36168419
190auditory behavior (GO:0031223)2.35964935
191negative regulation of DNA-dependent DNA replication (GO:2000104)2.35438360
192facial nerve structural organization (GO:0021612)2.33784340
193pyrimidine dimer repair (GO:0006290)2.33738924
194behavioral response to ethanol (GO:0048149)2.33207336
195positive regulation of neurotransmitter secretion (GO:0001956)2.32544131
196tRNA methylation (GO:0030488)2.31933702
197cell proliferation in forebrain (GO:0021846)2.31361091
198transferrin transport (GO:0033572)2.31360099

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.92283446
2SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.74829144
3EZH2_22144423_ChIP-Seq_EOC_Human4.30326261
4LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.87128229
5SCL_19346495_ChIP-Seq_HPC-7_Human3.83407336
6GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.00713738
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.94292255
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.78631105
9RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.74474110
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.71324324
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.70164971
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.67341745
13GATA1_19941826_ChIP-Seq_K562_Human2.63438597
14TAF15_26573619_Chip-Seq_HEK293_Human2.56021888
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.54465295
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.52592095
17LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.50407573
18GATA2_19941826_ChIP-Seq_K562_Human2.40246087
19GATA1_19941827_ChIP-Seq_MEL_Mouse2.39396181
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.36081803
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.35425327
22GATA2_21666600_ChIP-Seq_HMVEC_Human2.35291233
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.32479765
24POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31165244
25JARID2_20064375_ChIP-Seq_MESCs_Mouse2.28109175
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.27807145
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.25878723
28CBX2_27304074_Chip-Seq_ESCs_Mouse2.25429532
29GATA1_22025678_ChIP-Seq_K562_Human2.23845075
30PCGF2_27294783_Chip-Seq_ESCs_Mouse2.21980824
31BMI1_23680149_ChIP-Seq_NPCS_Mouse2.18644247
32EZH2_27304074_Chip-Seq_ESCs_Mouse2.15195470
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14161543
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.11401129
35P300_19829295_ChIP-Seq_ESCs_Human2.11088387
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.09137693
37HTT_18923047_ChIP-ChIP_STHdh_Human2.06064737
38TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.03492717
39CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00691735
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.98189567
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.97979233
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.97692386
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.92876141
44GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.91355437
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.88877821
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.88712077
47SPI1_23127762_ChIP-Seq_K562_Human1.87124980
48GATA1_22383799_ChIP-Seq_G1ME_Mouse1.87047865
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.86730586
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.85416779
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.84673140
52ELK4_26923725_Chip-Seq_MESODERM_Mouse1.83222497
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.80447162
54RNF2_18974828_ChIP-Seq_MESCs_Mouse1.80447162
55FUS_26573619_Chip-Seq_HEK293_Human1.79704368
56RNF2_27304074_Chip-Seq_NSC_Mouse1.78804390
57SMAD4_21799915_ChIP-Seq_A2780_Human1.72835425
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.71460539
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.71185530
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.71135328
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.71134977
62CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69146629
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.69040269
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.68908130
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.65363011
66RNF2_27304074_Chip-Seq_ESCs_Mouse1.64014351
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62124008
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.62087285
69GATA1_19941827_ChIP-Seq_MEL86_Mouse1.60101816
70REST_21632747_ChIP-Seq_MESCs_Mouse1.60044595
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59579704
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.58111062
73IGF1R_20145208_ChIP-Seq_DFB_Human1.56249260
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.55623885
75EZH2_27294783_Chip-Seq_ESCs_Mouse1.55228968
76E2F1_18555785_Chip-Seq_ESCs_Mouse1.54880416
77SUZ12_18555785_Chip-Seq_ESCs_Mouse1.54786597
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.54533168
79P53_22387025_ChIP-Seq_ESCs_Mouse1.53778901
80RUNX1_22412390_ChIP-Seq_EML_Mouse1.52023703
81STAT3_18555785_Chip-Seq_ESCs_Mouse1.51400583
82NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.51382251
83NRF2_20460467_ChIP-Seq_MEFs_Mouse1.51382251
84EWS_26573619_Chip-Seq_HEK293_Human1.49030535
85SUZ12_27294783_Chip-Seq_ESCs_Mouse1.48865925
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.48178653
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.47607214
88BP1_19119308_ChIP-ChIP_Hs578T_Human1.45254166
89CMYC_18555785_Chip-Seq_ESCs_Mouse1.45201960
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44680598
91VDR_22108803_ChIP-Seq_LS180_Human1.44480241
92EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.42937190
93NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42905146
94SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.41159270
95ER_23166858_ChIP-Seq_MCF-7_Human1.40559839
96PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39435818
97MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38889538
98P300_18555785_Chip-Seq_ESCs_Mouse1.38729002
99NMYC_18555785_Chip-Seq_ESCs_Mouse1.38082562
100AR_21572438_ChIP-Seq_LNCaP_Human1.37380646
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37089105
102ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36152070
103SOX2_18555785_Chip-Seq_ESCs_Mouse1.34935613
104RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34844474
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33673790
106HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33535001
107IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.32872993
108OCT4_18555785_Chip-Seq_ESCs_Mouse1.30780545
109IRF8_27001747_Chip-Seq_BMDM_Mouse1.28813533
110CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.28307284
111RUNX1_27457419_Chip-Seq_LIVER_Mouse1.26700291
112IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26182460
113SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25595886
114RUNX_20019798_ChIP-Seq_JUKART_Human1.25093867
115KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.24763322
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24685507
117AR_25329375_ChIP-Seq_VCAP_Human1.24453507
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24337172
119RUNX2_22187159_ChIP-Seq_PCA_Human1.24121692
120STAT3_23295773_ChIP-Seq_U87_Human1.21677626
121SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21505407
122ZFX_18555785_Chip-Seq_ESCs_Mouse1.21422088
123PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.21398563
124TCF4_23295773_ChIP-Seq_U87_Human1.21267530
125MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21190025
126STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.20454237
127FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.20446298
128AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18209893
129CTCF_18555785_Chip-Seq_ESCs_Mouse1.17895766
130PU1_27457419_Chip-Seq_LIVER_Mouse1.17163235
131DROSHA_22980978_ChIP-Seq_HELA_Human1.16197332
132ESR1_20079471_ChIP-ChIP_T-47D_Human1.15655562
133JUN_21703547_ChIP-Seq_K562_Human1.15526145
134LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15032402
135ESRRB_18555785_Chip-Seq_ESCs_Mouse1.14851111
136KLF4_18555785_Chip-Seq_ESCs_Mouse1.12616053
137TAL1_26923725_Chip-Seq_HPCs_Mouse1.11285625
138GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11272554
139SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09788682
140TP53_18474530_ChIP-ChIP_U2OS_Human1.08637650
141SMAD1_18555785_Chip-Seq_ESCs_Mouse1.08271722
142KDM2B_26808549_Chip-Seq_REH_Human1.07012871
143CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06876303
144SALL4_22934838_ChIP-ChIP_CD34+_Human1.06675246
145P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05094672
146ETS1_22383799_ChIP-Seq_G1ME_Mouse1.00843138
147FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00301180
148PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99621070
149PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97980299
150NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96756701
151TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94385997
152OCT1_27270436_Chip-Seq_PROSTATE_Human0.94203524
153SPI1_20517297_ChIP-Seq_HL60_Human0.93706397
154OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89691371
155TCF4_18268006_ChIP-ChIP_LS174T_Human0.89645000
156ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89534330
157CRX_20693478_ChIP-Seq_RETINA_Mouse0.86568810
158GF1_26923725_Chip-Seq_HPCs_Mouse0.83063895
159BCAT_22108803_ChIP-Seq_LS180_Human0.81546587
160GATA3_21878914_ChIP-Seq_MCF-7_Human0.80281546
161EGR1_23403033_ChIP-Seq_LIVER_Mouse0.79326998
162JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79004853
163NCOR1_26117541_ChIP-Seq_K562_Human0.78572813
164ERG_20517297_ChIP-Seq_VCAP_Human0.78393649
165SOX2_20726797_ChIP-Seq_SW620_Human0.77163262
166JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75934648
167EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.75306722
168FLI1_21867929_ChIP-Seq_TH2_Mouse0.74657294
169RARG_19884340_ChIP-ChIP_MEFs_Mouse0.73904476
170STAT6_21828071_ChIP-Seq_BEAS2B_Human0.73351156
171SOX2_19829295_ChIP-Seq_ESCs_Human0.73234454
172NANOG_19829295_ChIP-Seq_ESCs_Human0.73234454
173PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.72982207
174CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.72214235

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology9.77684714
2MP0000566_synostosis4.58296263
3MP0006292_abnormal_olfactory_placode3.38593889
4MP0004084_abnormal_cardiac_muscle3.38066186
5MP0000465_gastrointestinal_hemorrhage3.31763317
6MP0005646_abnormal_pituitary_gland3.08196061
7MP0005645_abnormal_hypothalamus_physiol3.04684608
8MP0001188_hyperpigmentation2.91276957
9MP0001986_abnormal_taste_sensitivity2.72238841
10MP0004036_abnormal_muscle_relaxation2.67784265
11MP0003880_abnormal_central_pattern2.64591882
12MP0002736_abnormal_nociception_after2.59849693
13MP0004130_abnormal_muscle_cell2.55932991
14MP0002277_abnormal_respiratory_mucosa2.54274122
15MP0005083_abnormal_biliary_tract2.51539442
16MP0000343_altered_response_to2.50136000
17MP0005171_absent_coat_pigmentation2.49907855
18MP0002163_abnormal_gland_morphology2.45001092
19MP0001968_abnormal_touch/_nociception2.41476793
20MP0010386_abnormal_urinary_bladder2.41406380
21MP0003787_abnormal_imprinting2.35913138
22MP0003303_peritoneal_inflammation2.22121991
23MP0005167_abnormal_blood-brain_barrier2.19353529
24MP0000230_abnormal_systemic_arterial2.16118064
25MP0002735_abnormal_chemical_nociception2.11685463
26MP0003566_abnormal_cell_adhesion2.09664071
27MP0005379_endocrine/exocrine_gland_phen2.09097745
28MP0002638_abnormal_pupillary_reflex2.06031554
29MP0009697_abnormal_copulation2.05610286
30MP0003941_abnormal_skin_development2.04588530
31MP0009745_abnormal_behavioral_response2.03255655
32MP0001486_abnormal_startle_reflex1.99636426
33MP0001502_abnormal_circadian_rhythm1.97700806
34MP0008775_abnormal_heart_ventricle1.87316111
35MP0003828_pulmonary_edema1.83459227
36MP0002572_abnormal_emotion/affect_behav1.83329152
37MP0001879_abnormal_lymphatic_vessel1.80183854
38MP0009046_muscle_twitch1.76539656
39MP0004215_abnormal_myocardial_fiber1.74541331
40MP0002557_abnormal_social/conspecific_i1.72631064
41MP0003183_abnormal_peptide_metabolism1.72426312
42MP0002064_seizures1.69991230
43MP0005423_abnormal_somatic_nervous1.69339025
44MP0006276_abnormal_autonomic_nervous1.66983811
45MP0005409_darkened_coat_color1.66754849
46MP0003635_abnormal_synaptic_transmissio1.66726131
47MP0004742_abnormal_vestibular_system1.65694082
48MP0003638_abnormal_response/metabolism_1.64146150
49MP0008004_abnormal_stomach_pH1.59432644
50MP0008872_abnormal_physiological_respon1.59320752
51MP0005257_abnormal_intraocular_pressure1.59060895
52MP0005084_abnormal_gallbladder_morpholo1.57237167
53MP0004859_abnormal_synaptic_plasticity1.55788149
54MP0001501_abnormal_sleep_pattern1.55425531
55MP0002063_abnormal_learning/memory/cond1.54303183
56MP0001851_eye_inflammation1.50566723
57MP0000015_abnormal_ear_pigmentation1.50420187
58MP0002067_abnormal_sensory_capabilities1.49003492
59MP0001835_abnormal_antigen_presentation1.47018779
60MP0002272_abnormal_nervous_system1.46074167
61MP0005410_abnormal_fertilization1.44266591
62MP0002876_abnormal_thyroid_physiology1.42167727
63MP0001984_abnormal_olfaction1.42105140
64MP0004484_altered_response_of1.36534441
65MP0003878_abnormal_ear_physiology1.36074192
66MP0005377_hearing/vestibular/ear_phenot1.36074192
67MP0002972_abnormal_cardiac_muscle1.35418380
68MP0005058_abnormal_lysosome_morphology1.33538750
69MP0010329_abnormal_lipoprotein_level1.33182572
70MP0000249_abnormal_blood_vessel1.31639016
71MP0000631_abnormal_neuroendocrine_gland1.30969949
72MP0002822_catalepsy1.29414405
73MP0005666_abnormal_adipose_tissue1.25932579
74MP0008874_decreased_physiological_sensi1.25272071
75MP0000678_abnormal_parathyroid_gland1.25088841
76MP0002249_abnormal_larynx_morphology1.21913004
77MP0002184_abnormal_innervation1.21820172
78MP0006138_congestive_heart_failure1.21323799
79MP0005620_abnormal_muscle_contractility1.20244578
80MP0005670_abnormal_white_adipose1.19213892
81MP0003136_yellow_coat_color1.19069759
82MP0010155_abnormal_intestine_physiology1.17794165
83MP0002734_abnormal_mechanical_nocicepti1.17439857
84MP0000778_abnormal_nervous_system1.16700139
85MP0001905_abnormal_dopamine_level1.14817071
86MP0009780_abnormal_chondrocyte_physiolo1.14668153
87MP0000049_abnormal_middle_ear1.13327865
88MP0001545_abnormal_hematopoietic_system1.11422134
89MP0005397_hematopoietic_system_phenotyp1.11422134
90MP0001970_abnormal_pain_threshold1.11180013
91MP0001529_abnormal_vocalization1.10878315
92MP0002132_abnormal_respiratory_system1.09614775
93MP0005385_cardiovascular_system_phenoty1.09118962
94MP0001544_abnormal_cardiovascular_syste1.09118962
95MP0005000_abnormal_immune_tolerance1.08368524
96MP0008058_abnormal_DNA_repair1.08232288
97MP0004924_abnormal_behavior1.07747803
98MP0005386_behavior/neurological_phenoty1.07747803
99MP0002396_abnormal_hematopoietic_system1.07109218
100MP0002398_abnormal_bone_marrow1.04766525
101MP0008877_abnormal_DNA_methylation1.04657433
102MP0009763_increased_sensitivity_to1.04259769
103MP0001963_abnormal_hearing_physiology1.03705132
104MP0001663_abnormal_digestive_system1.03507978
105MP0005535_abnormal_body_temperature1.02271679
106MP0005165_increased_susceptibility_to1.00043292
107MP0000026_abnormal_inner_ear0.99173785
108MP0003879_abnormal_hair_cell0.97757774
109MP0003122_maternal_imprinting0.97672429
110MP0001440_abnormal_grooming_behavior0.97610960
111MP0003724_increased_susceptibility_to0.96955704
112MP0002733_abnormal_thermal_nociception0.96708063
113MP0000372_irregular_coat_pigmentation0.95905602
114MP0004142_abnormal_muscle_tone0.95401179
115MP0004782_abnormal_surfactant_physiolog0.95222577
116MP0002332_abnormal_exercise_endurance0.93577787
117MP0006036_abnormal_mitochondrial_physio0.93219607
118MP0010368_abnormal_lymphatic_system0.93163327
119MP0009642_abnormal_blood_homeostasis0.92661668
120MP0003186_abnormal_redox_activity0.90961456
121MP0004134_abnormal_chest_morphology0.90730833
122MP0009250_abnormal_appendicular_skeleto0.90432474
123MP0005551_abnormal_eye_electrophysiolog0.90341720
124MP0000858_altered_metastatic_potential0.90298697
125MP0003656_abnormal_erythrocyte_physiolo0.89060411
126MP0004947_skin_inflammation0.88639412
127MP0008569_lethality_at_weaning0.88468475
128MP0004133_heterotaxia0.88148434
129MP0000681_abnormal_thyroid_gland0.86538753
130MP0002118_abnormal_lipid_homeostasis0.85586375
131MP0002095_abnormal_skin_pigmentation0.83871906
132MP0001533_abnormal_skeleton_physiology0.81518010
133MP0004510_myositis0.79444631
134MP0002128_abnormal_blood_circulation0.79119664
135MP0002102_abnormal_ear_morphology0.78902166
136MP0009379_abnormal_foot_pigmentation0.76449374
137MP0001765_abnormal_ion_homeostasis0.75776324
138MP0000516_abnormal_urinary_system0.75704209
139MP0005367_renal/urinary_system_phenotyp0.75704209
140MP0000689_abnormal_spleen_morphology0.73699108
141MP0002938_white_spotting0.73619801
142MP0001177_atelectasis0.73519105
143MP0005671_abnormal_response_to0.73354285
144MP0001756_abnormal_urination0.73290149
145MP0003075_altered_response_to0.72955235
146MP0004085_abnormal_heartbeat0.72923250
147MP0004270_analgesia0.72823316
148MP0002723_abnormal_immune_serum0.72162131
149MP0002751_abnormal_autonomic_nervous0.70823845
150MP0009765_abnormal_xenobiotic_induced0.70800060
151MP0009764_decreased_sensitivity_to0.70423837
152MP0005248_abnormal_Harderian_gland0.70047450
153MP0003121_genomic_imprinting0.69287382
154MP0002116_abnormal_craniofacial_bone0.68349047
155MP0001800_abnormal_humoral_immune0.68056488
156MP0005365_abnormal_bile_salt0.67164561
157MP0002429_abnormal_blood_cell0.66646133
158MP0003385_abnormal_body_wall0.65896233
159MP0003011_delayed_dark_adaptation0.65748791
160MP0003866_abnormal_defecation0.64353637
161MP0005381_digestive/alimentary_phenotyp0.64283278
162MP0001664_abnormal_digestion0.62726720
163MP0002452_abnormal_antigen_presenting0.62676654
164MP0005253_abnormal_eye_physiology0.62415826
165MP0002066_abnormal_motor_capabilities/c0.61708658
166MP0003300_gastrointestinal_ulcer0.61401807
167MP0000955_abnormal_spinal_cord0.60815651
168MP0002722_abnormal_immune_system0.60204481
169MP0008057_abnormal_DNA_replication0.60054663
170MP0002148_abnormal_hypersensitivity_rea0.59986608
171MP0002998_abnormal_bone_remodeling0.59735190
172MP0001661_extended_life_span0.59240827
173MP0005174_abnormal_tail_pigmentation0.58420187
174MP0005501_abnormal_skin_physiology0.55625890
175MP0001845_abnormal_inflammatory_respons0.55588388
176MP0005375_adipose_tissue_phenotype0.55016090
177MP0005023_abnormal_wound_healing0.54460807
178MP0005085_abnormal_gallbladder_physiolo0.52408468

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)9.55354587
2Purpura (HP:0000979)8.87186816
3Epistaxis (HP:0000421)7.47347730
4Gingival bleeding (HP:0000225)6.34705795
5Impaired platelet aggregation (HP:0003540)6.03028587
6Abnormal platelet function (HP:0011869)6.03028587
7Hyperlipoproteinemia (HP:0010980)6.01566714
8Acanthocytosis (HP:0001927)4.18010095
9Spontaneous hematomas (HP:0007420)4.08497460
10Focal motor seizures (HP:0011153)4.08163945
11Poikilocytosis (HP:0004447)4.07211243
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.84865509
13Conjunctival telangiectasia (HP:0000524)3.75979133
14Febrile seizures (HP:0002373)3.75723191
15Dyschromatopsia (HP:0007641)3.69440354
16Abnormal pupillary function (HP:0007686)3.39815697
17Paralysis (HP:0003470)3.37715666
18Dynein arm defect of respiratory motile cilia (HP:0012255)3.36476082
19Absent/shortened dynein arms (HP:0200106)3.36476082
20Chromsome breakage (HP:0040012)3.35788317
21Morphological abnormality of the middle ear (HP:0008609)3.29969100
22Abnormality of the common coagulation pathway (HP:0010990)3.17410118
23Bruising susceptibility (HP:0000978)3.16642817
24Abnormality of the vasculature of the conjunctiva (HP:0008054)3.16157546
25Abnormality of lateral ventricle (HP:0030047)3.11479151
26Chronic hepatic failure (HP:0100626)3.04859486
27Increased density of long bones (HP:0006392)2.98109755
28Abnormality of incisor morphology (HP:0011063)2.88875522
29Septo-optic dysplasia (HP:0100842)2.85231964
30Abnormality of the heme biosynthetic pathway (HP:0010472)2.83752068
31Osteomalacia (HP:0002749)2.83130872
32Hyperventilation (HP:0002883)2.78919598
33Abnormal auditory evoked potentials (HP:0006958)2.76502323
34Abnormal hair whorl (HP:0010721)2.72880142
35True hermaphroditism (HP:0010459)2.70712520
36Cerebral palsy (HP:0100021)2.67232062
37Upper limb muscle weakness (HP:0003484)2.65168443
38Epileptic encephalopathy (HP:0200134)2.65023566
39Tubulointerstitial nephritis (HP:0001970)2.64981866
40Medial flaring of the eyebrow (HP:0010747)2.64811789
41Tented upper lip vermilion (HP:0010804)2.62138684
42Protruding tongue (HP:0010808)2.58546720
43Optic nerve hypoplasia (HP:0000609)2.57277418
44Limb dystonia (HP:0002451)2.51040906
45Nephrogenic diabetes insipidus (HP:0009806)2.47409778
46Follicular hyperkeratosis (HP:0007502)2.39769142
47Abnormal respiratory motile cilium morphology (HP:0005938)2.37434142
48Abnormal respiratory epithelium morphology (HP:0012253)2.37434142
49Abnormal ciliary motility (HP:0012262)2.36692618
50Ventricular fibrillation (HP:0001663)2.35752461
51Pancreatic fibrosis (HP:0100732)2.35651593
52Abnormality of molar morphology (HP:0011070)2.34839010
53Abnormality of molar (HP:0011077)2.34839010
54Duplicated collecting system (HP:0000081)2.33220297
55Hepatosplenomegaly (HP:0001433)2.28320371
56Gait imbalance (HP:0002141)2.27574998
57Congenital primary aphakia (HP:0007707)2.26384921
58Joint hemorrhage (HP:0005261)2.25542611
59Xanthomatosis (HP:0000991)2.23543091
60Abnormality of dental color (HP:0011073)2.23426094
61Abnormality of the dental root (HP:0006486)2.23222330
62Taurodontia (HP:0000679)2.23222330
63Abnormality of permanent molar morphology (HP:0011071)2.23222330
64Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.22793011
65Hypoplasia of the fovea (HP:0007750)2.22780478
66Aplasia/Hypoplasia of the fovea (HP:0008060)2.22780478
67Generalized aminoaciduria (HP:0002909)2.22211880
68Muscle fiber splitting (HP:0003555)2.20332117
69Nephronophthisis (HP:0000090)2.19357967
70Abnormality of the renal collecting system (HP:0004742)2.17745221
71Abnormality of the dental pulp (HP:0006479)2.17685021
72Retrobulbar optic neuritis (HP:0100654)2.17083696
73Optic neuritis (HP:0100653)2.17083696
74Bundle branch block (HP:0011710)2.14811068
75Absent eyebrow (HP:0002223)2.13870940
76Intestinal atresia (HP:0011100)2.13541530
77Papillary thyroid carcinoma (HP:0002895)2.12308845
78Tinnitus (HP:0000360)2.12252832
79Thyroid-stimulating hormone excess (HP:0002925)2.11847037
80Decreased central vision (HP:0007663)2.11561975
81Pancreatic cysts (HP:0001737)2.09609158
82Nemaline bodies (HP:0003798)2.08457912
83Joint swelling (HP:0001386)2.08323451
84Hyperthyroidism (HP:0000836)2.05343508
85Patchy hypopigmentation of hair (HP:0011365)2.04501734
86Spontaneous abortion (HP:0005268)2.03341495
87Conical tooth (HP:0000698)2.02867742
88Fibular aplasia (HP:0002990)2.01993983
893-Methylglutaconic aciduria (HP:0003535)2.01687072
90Preaxial hand polydactyly (HP:0001177)2.01013247
91Abnormality of the fovea (HP:0000493)2.00953853
92Atonic seizures (HP:0010819)2.00404269
93Prolonged bleeding time (HP:0003010)11.7393140
94Increased mean platelet volume (HP:0011877)10.8420144
95Menorrhagia (HP:0000132)10.5608854
96Abnormal platelet volume (HP:0011876)10.1287151
97Recurrent corneal erosions (HP:0000495)1.99781232
98Abnormality of the renal medulla (HP:0100957)1.96130212
99Occipital encephalocele (HP:0002085)1.95172743
100Hypothermia (HP:0002045)1.95083650
101Molar tooth sign on MRI (HP:0002419)1.94680329
102Abnormality of midbrain morphology (HP:0002418)1.94680329
103Abnormality of binocular vision (HP:0011514)1.94104274
104Diplopia (HP:0000651)1.94104274
105Nausea (HP:0002018)1.94081708
106Muscle fiber inclusion bodies (HP:0100299)1.93888998
107Stomach cancer (HP:0012126)1.92942683
108Hypophosphatemic rickets (HP:0004912)1.92107547
109Abnormality of calcium-phosphate metabolism (HP:0100530)1.91055344
110Tongue fasciculations (HP:0001308)1.90666523
111Alveolar cell carcinoma (HP:0006519)1.90308497
112Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.89380707
113Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89225009
114Oligohydramnios (HP:0001562)1.88767678
115Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.87827114
116Abnormality of iron homeostasis (HP:0011031)1.87099538
117Aplasia/hypoplasia of the uterus (HP:0008684)1.86949746
118Male infertility (HP:0003251)1.86667833
119White forelock (HP:0002211)1.86641043
120Recurrent pneumonia (HP:0006532)1.85092186
121Distal lower limb amyotrophy (HP:0008944)1.84801348
122Stomatitis (HP:0010280)1.83879645
123Congenital sensorineural hearing impairment (HP:0008527)1.82180659
124Parakeratosis (HP:0001036)1.81980408
125Polycythemia (HP:0001901)1.81875474
126Aplasia/Hypoplasia of the uvula (HP:0010293)1.81831284
127Renal dysplasia (HP:0000110)1.81731094
128Aganglionic megacolon (HP:0002251)1.81616698
129Astigmatism (HP:0000483)1.81538879
130Alopecia of scalp (HP:0002293)1.81120343
131Aplasia/Hypoplasia of the tibia (HP:0005772)1.80286830
132Fibular hypoplasia (HP:0003038)1.80014323
133Growth hormone deficiency (HP:0000824)1.79174699
134J-shaped sella turcica (HP:0002680)1.79108731
135Fair hair (HP:0002286)1.78332666
136Muscle fibrillation (HP:0010546)1.78292723
137Hyperphosphatemia (HP:0002905)1.76945517
138Aplasia cutis congenita (HP:0001057)1.74988555
139Generalized hypopigmentation of hair (HP:0011358)1.73587835
140Abnormal respiratory motile cilium physiology (HP:0012261)1.73385904
141Prostate neoplasm (HP:0100787)1.72474772
142Large eyes (HP:0001090)1.72199587
143Poor coordination (HP:0002370)1.72143123
144Duplication of thumb phalanx (HP:0009942)1.72006010
145Clubbing of toes (HP:0100760)1.71083982
146Abnormality of the septum pellucidum (HP:0007375)1.70946561
147Corneal dystrophy (HP:0001131)1.70162023
148Genital tract atresia (HP:0001827)1.69549195
149Increased IgM level (HP:0003496)1.69410269
150Meckel diverticulum (HP:0002245)1.69371628
151Aplasia/Hypoplasia of the fibula (HP:0006492)1.68775150
152Dysautonomia (HP:0002459)1.68760147
153Abnormality of the parietal bone (HP:0002696)1.68752118
154Biliary tract neoplasm (HP:0100574)1.68654663
155Absent septum pellucidum (HP:0001331)1.66858422
156Progressive sensorineural hearing impairment (HP:0000408)1.66727450
157Hyporeflexia of lower limbs (HP:0002600)1.63909279
158Myocardial infarction (HP:0001658)1.62186693
159Abnormality of transition element cation homeostasis (HP:0011030)1.62066538
160Arterial thrombosis (HP:0004420)1.61010618
161Abnormality of skeletal muscle fiber size (HP:0012084)1.60902577
162Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.59710976
163Abnormality of alanine metabolism (HP:0010916)1.59710976
164Hyperalaninemia (HP:0003348)1.59710976
165Vertigo (HP:0002321)1.56589501
166Episodic fever (HP:0001954)1.56040332
167Abnormality of macrophages (HP:0004311)1.56008832
168Aortic aneurysm (HP:0004942)1.55795344
169Exercise-induced myalgia (HP:0003738)1.53173029
170Polyphagia (HP:0002591)1.50883327
171Lower limb amyotrophy (HP:0007210)1.49752619
172Central scotoma (HP:0000603)1.47726075
173Testicular neoplasm (HP:0010788)1.46681567
174Mitral stenosis (HP:0001718)1.45171558
175Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.44554428
176Basal ganglia calcification (HP:0002135)1.44415729
177Uterine leiomyosarcoma (HP:0002891)1.44404496
178Leiomyosarcoma (HP:0100243)1.44404496
179Increased serum ferritin (HP:0003281)1.44090322
180Abnormality of the prostate (HP:0008775)1.39494210
181Obstructive lung disease (HP:0006536)1.37962126
182Chronic obstructive pulmonary disease (HP:0006510)1.37962126
183Thyroid carcinoma (HP:0002890)1.37359081
184Insidious onset (HP:0003587)1.36164893
185Termporal pattern (HP:0011008)1.36164893
186Intellectual disability, profound (HP:0002187)1.35704004
187Back pain (HP:0003418)1.35221038
188Encephalitis (HP:0002383)1.35154177
189Hypomagnesemia (HP:0002917)1.34652312
190Areflexia of lower limbs (HP:0002522)1.34574363
191Transitional cell carcinoma of the bladder (HP:0006740)1.32651265
192Increased variability in muscle fiber diameter (HP:0003557)1.31366356
193Arthropathy (HP:0003040)1.31156166
194Visual hallucinations (HP:0002367)1.30729309

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.94536720
2MST44.32152572
3MAP2K74.18812295
4BMX4.12103064
5SIK33.87327610
6MYLK3.68634906
7TRIM283.40056476
8EIF2AK13.12536189
9PTK2B2.57752225
10BTK2.56883899
11MAP3K122.55470997
12PIK3CG2.48755055
13MKNK22.43327566
14TXK2.41434894
15SIK22.36155069
16BMPR1B2.23796624
17MAP3K42.23183865
18SGK22.18945915
19PRPF4B2.18922719
20STK162.14907588
21TNIK2.12151641
22CSF1R2.07716893
23NTRK32.03000157
24EPHA41.97960928
25CDK191.93577498
26CCNB11.88733187
27ILK1.88124499
28LMTK21.83823462
29TAOK31.83009184
30ZAP701.79065954
31ADRBK21.74588842
32ARAF1.69410669
33MAP3K141.67517944
34SRPK11.66892299
35BMPR21.64841431
36YES11.60593667
37BLK1.58547490
38ACVR1B1.54735807
39ZAK1.53824211
40CDK81.50117040
41STK31.45187712
42MAPKAPK31.43068653
43SGK2231.37855030
44SGK4941.37855030
45GRK61.33190148
46FGR1.32943724
47MAPK131.32581725
48MKNK11.32541996
49PNCK1.31190054
50SGK31.26100751
51MAP2K41.24690938
52PHKG11.23606246
53PHKG21.23606246
54OBSCN1.21134307
55STK38L1.17604077
56ITK1.16600143
57CDK31.16336535
58MUSK1.16295902
59PAK11.15226854
60HCK1.11486957
61PLK21.11163375
62INSRR1.10534226
63DAPK31.09747747
64TSSK61.06897895
65STK241.04927564
66GRK70.99886081
67MINK10.97765128
68IRAK30.96409103
69AKT30.96217192
70MAPK120.95208995
71TAOK20.94960624
72ERBB30.91368157
73JAK30.90821137
74PLK30.90462319
75MARK10.90032033
76IRAK40.88820408
77BRD40.88256924
78PRKCE0.85951021
79MAP2K30.85800002
80EIF2AK20.82677787
81PDK10.78995801
82MAP3K30.78599927
83DYRK1A0.77924337
84KIT0.76399640
85KSR10.74560988
86TEC0.74085738
87NTRK20.72623911
88CHEK20.72057474
89PRKD10.71904380
90VRK10.70756145
91TNK20.69999272
92PINK10.69924267
93PRKACG0.64174124
94ERBB40.62958149
95PRKCG0.61739208
96MAP2K10.57988071
97CHUK0.56965491
98ERBB20.55299506
99NEK60.54693146
100MAPK70.54585350
101FES0.54507304
102STK390.54493510
103MATK0.54213647
104DAPK10.54081806
105PKN10.54017149
106PDGFRB0.53221036
107RET0.53109292
108PLK40.52804367
109CAMK10.52576686
110IRAK20.52351915
111ATR0.50405989
112PDPK10.49590149
113NEK90.49217799
114GRK10.47919011
115CAMK2A0.47429661
116FER0.47137705
117DAPK20.46983642
118IKBKB0.46948791
119CSNK1A10.46609265
120RIPK40.46342349
121DDR20.45943553
122SGK10.45650713
123PRKCQ0.44106085
124ADRBK10.43634890
125RAF10.43394164
126FYN0.43312614
127MAP3K60.42813037
128PAK30.41928149
129RPS6KB10.41602701
130GRK50.40436841
131MAP3K50.38190149
132CAMK40.37844312
133SIK10.37146058
134PRKG20.36452191
135EPHA20.36240422
136CAMKK20.35759891
137CAMK2G0.35096637
138STK40.34708348
139SYK0.32363796
140PRKG10.31722035
141JAK10.31709187
142ROCK10.31706305
143MARK30.30614424
144CDK70.30035815
145JAK20.29829015
146PRKCB0.29325739
147IRAK10.28698955
148TTN0.28528995
149PIM20.27993218
150PRKCD0.27918395
151LCK0.27614882
152PRKACA0.27458206
153PRKCA0.27452946
154DMPK0.26879448
155PRKD20.26274301
156BRAF0.26025152
157MAP3K130.25614451
158BCR0.25366763
159ATM0.23101855
160LYN0.22949398
161OXSR10.22514973

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046115.70213223
2Nicotine addiction_Homo sapiens_hsa050333.81606357
3Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.38772160
4Collecting duct acid secretion_Homo sapiens_hsa049662.83983626
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.67208166
6Taste transduction_Homo sapiens_hsa047422.45603210
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.44476710
8Synaptic vesicle cycle_Homo sapiens_hsa047212.40830263
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.36564218
10ECM-receptor interaction_Homo sapiens_hsa045122.35256773
11Gap junction_Homo sapiens_hsa045402.27579841
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.17222746
13Type I diabetes mellitus_Homo sapiens_hsa049402.09545072
14Pancreatic secretion_Homo sapiens_hsa049722.08626002
15Morphine addiction_Homo sapiens_hsa050322.07118726
16Nitrogen metabolism_Homo sapiens_hsa009102.01857144
17Rheumatoid arthritis_Homo sapiens_hsa053232.00976634
18Fanconi anemia pathway_Homo sapiens_hsa034601.99517015
19Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.94599832
20Serotonergic synapse_Homo sapiens_hsa047261.91854382
21Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.81852629
22GABAergic synapse_Homo sapiens_hsa047271.75575498
23Glutamatergic synapse_Homo sapiens_hsa047241.65946725
24Circadian entrainment_Homo sapiens_hsa047131.62977593
25Graft-versus-host disease_Homo sapiens_hsa053321.57332636
26Glycerolipid metabolism_Homo sapiens_hsa005611.56877214
27Homologous recombination_Homo sapiens_hsa034401.56364878
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.45167851
29Alcoholism_Homo sapiens_hsa050341.39577457
30African trypanosomiasis_Homo sapiens_hsa051431.37885046
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36343634
32Autoimmune thyroid disease_Homo sapiens_hsa053201.36049168
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.35977692
34Allograft rejection_Homo sapiens_hsa053301.34469329
35Vibrio cholerae infection_Homo sapiens_hsa051101.29816149
36Insulin secretion_Homo sapiens_hsa049111.25934707
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24766653
38Dilated cardiomyopathy_Homo sapiens_hsa054141.22990689
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.20284237
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19762898
41Calcium signaling pathway_Homo sapiens_hsa040201.18535972
42Fatty acid elongation_Homo sapiens_hsa000621.17839490
43Amphetamine addiction_Homo sapiens_hsa050311.16725825
44Regulation of actin cytoskeleton_Homo sapiens_hsa048101.15722523
45Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.15562853
46Circadian rhythm_Homo sapiens_hsa047101.14849160
47Gastric acid secretion_Homo sapiens_hsa049711.13241930
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.12251166
49Endocytosis_Homo sapiens_hsa041441.12219991
50Systemic lupus erythematosus_Homo sapiens_hsa053221.11762339
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11713150
52Phospholipase D signaling pathway_Homo sapiens_hsa040721.10565125
53Long-term depression_Homo sapiens_hsa047301.10132450
54Cocaine addiction_Homo sapiens_hsa050301.09002677
55Oxidative phosphorylation_Homo sapiens_hsa001901.06730019
56B cell receptor signaling pathway_Homo sapiens_hsa046621.06219899
57cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05161164
58Phagosome_Homo sapiens_hsa041451.04958772
59Olfactory transduction_Homo sapiens_hsa047401.04517818
60Phototransduction_Homo sapiens_hsa047441.03658516
61beta-Alanine metabolism_Homo sapiens_hsa004101.02025649
62Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01070711
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00000876
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.98440053
65Hematopoietic cell lineage_Homo sapiens_hsa046400.98287810
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97753187
67Focal adhesion_Homo sapiens_hsa045100.97398208
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.94965642
69RNA degradation_Homo sapiens_hsa030180.93381023
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89987768
71Rap1 signaling pathway_Homo sapiens_hsa040150.89044551
72Shigellosis_Homo sapiens_hsa051310.88817701
73Measles_Homo sapiens_hsa051620.85527640
74Fat digestion and absorption_Homo sapiens_hsa049750.84976935
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84956629
76Sphingolipid metabolism_Homo sapiens_hsa006000.84900704
77Sulfur metabolism_Homo sapiens_hsa009200.83572216
78Cholinergic synapse_Homo sapiens_hsa047250.83103492
79Starch and sucrose metabolism_Homo sapiens_hsa005000.82984492
80Linoleic acid metabolism_Homo sapiens_hsa005910.82808081
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80932135
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80630053
83Long-term potentiation_Homo sapiens_hsa047200.80533344
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80283596
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.80238046
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80156653
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79923650
88Salivary secretion_Homo sapiens_hsa049700.79731114
89Protein export_Homo sapiens_hsa030600.79037213
90Axon guidance_Homo sapiens_hsa043600.77131699
91Choline metabolism in cancer_Homo sapiens_hsa052310.76202311
92Basal transcription factors_Homo sapiens_hsa030220.75572252
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74464179
94PPAR signaling pathway_Homo sapiens_hsa033200.74279331
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72738414
96Dopaminergic synapse_Homo sapiens_hsa047280.72737551
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72315870
98Asthma_Homo sapiens_hsa053100.71889506
99Renin-angiotensin system_Homo sapiens_hsa046140.70834644
100Arginine and proline metabolism_Homo sapiens_hsa003300.70775696
101Primary immunodeficiency_Homo sapiens_hsa053400.70073140
102Wnt signaling pathway_Homo sapiens_hsa043100.69556951
103Melanoma_Homo sapiens_hsa052180.68805740
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.67990820
105Renin secretion_Homo sapiens_hsa049240.66879860
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66485743
107Glutathione metabolism_Homo sapiens_hsa004800.66395809
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65993526
109ErbB signaling pathway_Homo sapiens_hsa040120.64926851
110Malaria_Homo sapiens_hsa051440.64334320
111Non-homologous end-joining_Homo sapiens_hsa034500.64193923
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61875286
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61571307
114cAMP signaling pathway_Homo sapiens_hsa040240.58525579
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56955966
116Ovarian steroidogenesis_Homo sapiens_hsa049130.56242174
117Ether lipid metabolism_Homo sapiens_hsa005650.55061346
118Tuberculosis_Homo sapiens_hsa051520.55038339
119Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54967927
120Ras signaling pathway_Homo sapiens_hsa040140.54895004
121Glioma_Homo sapiens_hsa052140.54861600
122Bile secretion_Homo sapiens_hsa049760.54315415
123MAPK signaling pathway_Homo sapiens_hsa040100.53987778
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52656167
125Regulation of autophagy_Homo sapiens_hsa041400.52623566
126Mineral absorption_Homo sapiens_hsa049780.51583800
127Oxytocin signaling pathway_Homo sapiens_hsa049210.51346499
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.50936208
129Arachidonic acid metabolism_Homo sapiens_hsa005900.50122544
130Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50026588
131Purine metabolism_Homo sapiens_hsa002300.49656295
132Non-small cell lung cancer_Homo sapiens_hsa052230.49243936
133Pentose phosphate pathway_Homo sapiens_hsa000300.47483925
134Alzheimers disease_Homo sapiens_hsa050100.46391987
135Pancreatic cancer_Homo sapiens_hsa052120.46304313
136Renal cell carcinoma_Homo sapiens_hsa052110.44689481
137TNF signaling pathway_Homo sapiens_hsa046680.44658281
138RNA polymerase_Homo sapiens_hsa030200.44430647
139Influenza A_Homo sapiens_hsa051640.42633438
140Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41282656
141Endometrial cancer_Homo sapiens_hsa052130.41082075
142Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40838771
143Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39524582
144Steroid hormone biosynthesis_Homo sapiens_hsa001400.39229726
145ABC transporters_Homo sapiens_hsa020100.37873151
146Type II diabetes mellitus_Homo sapiens_hsa049300.37721410
147Maturity onset diabetes of the young_Homo sapiens_hsa049500.37689555
148Insulin signaling pathway_Homo sapiens_hsa049100.37497127
149Fatty acid biosynthesis_Homo sapiens_hsa000610.37149275
150Vascular smooth muscle contraction_Homo sapiens_hsa042700.37145360
151Chemokine signaling pathway_Homo sapiens_hsa040620.36910582
152Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36829388
153VEGF signaling pathway_Homo sapiens_hsa043700.35048304
154Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34634604
155Small cell lung cancer_Homo sapiens_hsa052220.34130853
156Amoebiasis_Homo sapiens_hsa051460.33645296
157Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33605934
158Viral carcinogenesis_Homo sapiens_hsa052030.33044046
159T cell receptor signaling pathway_Homo sapiens_hsa046600.32156693
160Prolactin signaling pathway_Homo sapiens_hsa049170.32108928
161Huntingtons disease_Homo sapiens_hsa050160.31533009
162Herpes simplex infection_Homo sapiens_hsa051680.31421640
163Mismatch repair_Homo sapiens_hsa034300.30959438
164Leishmaniasis_Homo sapiens_hsa051400.28398894

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