SPZ1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a bHLH-zip transcription factor which functions in the mitogen-activate protein kinase (MAPK) signaling pathway. Because of its role in the upregulation of cell proliferation and tumorigenesis, this gene may serve as a target for Ras-induced tumor treatments. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.88926993
2axonemal dynein complex assembly (GO:0070286)9.71442466
3reproduction (GO:0000003)9.44584392
4motile cilium assembly (GO:0044458)9.22395709
5cilium or flagellum-dependent cell motility (GO:0001539)9.12548432
6response to pheromone (GO:0019236)8.96910031
7regulation of cilium movement (GO:0003352)8.85149019
8cilium movement (GO:0003341)8.08032280
9single fertilization (GO:0007338)7.51949221
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.42559633
11sperm capacitation (GO:0048240)7.38643586
12negative regulation of inclusion body assembly (GO:0090084)7.29351780
13synaptonemal complex organization (GO:0070193)7.03319645
14male meiosis (GO:0007140)6.92045662
15synaptonemal complex assembly (GO:0007130)6.89742993
16spermatogenesis (GO:0007283)6.81141584
17protein targeting to Golgi (GO:0000042)6.81064463
18male gamete generation (GO:0048232)6.78709051
19rRNA methylation (GO:0031167)6.78708083
20microtubule depolymerization (GO:0007019)6.77961112
21piRNA metabolic process (GO:0034587)6.77923979
22organic cation transport (GO:0015695)6.58560254
23establishment of protein localization to Golgi (GO:0072600)6.58354959
24phosphatidylethanolamine biosynthetic process (GO:0006646)6.48270971
25fertilization (GO:0009566)6.37078762
26retrograde transport, vesicle recycling within Golgi (GO:0000301)6.34015710
27gamete generation (GO:0007276)6.24616754
28regulation of inclusion body assembly (GO:0090083)6.08327648
29phosphatidylethanolamine metabolic process (GO:0046337)6.03671521
30centriole replication (GO:0007099)5.89490164
31rRNA modification (GO:0000154)5.71309676
32calcium ion-dependent exocytosis (GO:0017156)5.59284157
33germ cell development (GO:0007281)5.47758283
34regulation of Rab GTPase activity (GO:0032313)5.41691836
35positive regulation of Rab GTPase activity (GO:0032851)5.41691836
36cellular process involved in reproduction in multicellular organism (GO:0022412)5.41243087
37cellular ketone body metabolic process (GO:0046950)5.38029232
38chromosome condensation (GO:0030261)5.30404219
39regulation of microtubule-based movement (GO:0060632)5.24186505
40glycerol ether metabolic process (GO:0006662)5.19840944
41ventricular system development (GO:0021591)5.19194480
42centriole assembly (GO:0098534)5.10106896
43DNA packaging (GO:0006323)5.01194411
44spermatid nucleus differentiation (GO:0007289)4.99438467
45protein localization to Golgi apparatus (GO:0034067)4.99106929
46regulation of transcription involved in cell fate commitment (GO:0060850)4.99080945
47cell recognition (GO:0008037)4.96633348
48multicellular organismal reproductive process (GO:0048609)4.93189470
49male meiosis I (GO:0007141)4.87117296
50ether metabolic process (GO:0018904)4.80421503
51regulation of centriole replication (GO:0046599)4.79301869
52ketone body metabolic process (GO:1902224)4.74129509
53microtubule severing (GO:0051013)4.70052682
54seminiferous tubule development (GO:0072520)4.66641879
55chromosome organization involved in meiosis (GO:0070192)4.66214965
56DNA methylation involved in gamete generation (GO:0043046)4.35588972
57sexual reproduction (GO:0019953)4.30122491
58left/right pattern formation (GO:0060972)4.28870387
59chaperone-mediated protein complex assembly (GO:0051131)4.17123576
60meiotic nuclear division (GO:0007126)4.15710283
61single strand break repair (GO:0000012)4.14854776
62antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.05090977
63musculoskeletal movement (GO:0050881)4.04801615
64multicellular organismal movement (GO:0050879)4.04801615
65multicellular organismal development (GO:0007275)3.95585881
66meiosis I (GO:0007127)3.92005609
67regulation of somitogenesis (GO:0014807)3.91718843
68negative regulation of Rho protein signal transduction (GO:0035024)3.91605175
69coenzyme catabolic process (GO:0009109)3.71162523
70genitalia morphogenesis (GO:0035112)3.66198757
71monoubiquitinated protein deubiquitination (GO:0035520)3.62799178
72response to acidic pH (GO:0010447)3.54939221
73microtubule nucleation (GO:0007020)3.49567268
74protein polyglutamylation (GO:0018095)3.48751416
75microtubule polymerization or depolymerization (GO:0031109)3.48721587
76sequestering of actin monomers (GO:0042989)3.46030330
77protein K11-linked deubiquitination (GO:0035871)3.45026501
78cerebral cortex neuron differentiation (GO:0021895)3.44744384
79protein refolding (GO:0042026)3.38045915
80peptidyl-threonine dephosphorylation (GO:0035970)3.35165333
81glycolytic process (GO:0006096)3.34368358
82regulation of spindle checkpoint (GO:0090231)3.33715700
83Golgi to endosome transport (GO:0006895)3.33067136
84regulation of T-helper 2 cell differentiation (GO:0045628)3.31593595
85cellular response to pH (GO:0071467)3.29324394
86meiotic cell cycle (GO:0051321)3.29131188
87membrane protein intracellular domain proteolysis (GO:0031293)3.26646280
88regulation of interleukin-13 production (GO:0032656)3.20537171
89nucleus organization (GO:0006997)3.18587490
90mitotic sister chromatid cohesion (GO:0007064)3.15199601
91cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.15164621
92nucleoside diphosphate phosphorylation (GO:0006165)3.11502120
93histone H3-K9 demethylation (GO:0033169)3.09493566
94polyol catabolic process (GO:0046174)3.09364485
95carnitine transport (GO:0015879)3.06509080
96amino-acid betaine transport (GO:0015838)3.06509080
97homeostasis of number of cells within a tissue (GO:0048873)3.04813156
98detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.03326471
99protein localization to cilium (GO:0061512)3.02681935
100protein depolymerization (GO:0051261)3.00594016
101alditol metabolic process (GO:0019400)2.98159666
102polyamine biosynthetic process (GO:0006596)2.93002221
103GTP biosynthetic process (GO:0006183)2.91837422
104mitochondrial fission (GO:0000266)2.88924652
105regulation of phosphoprotein phosphatase activity (GO:0043666)2.88078092
106carnitine transmembrane transport (GO:1902603)2.87092891
107DNA conformation change (GO:0071103)2.86685836
108cranial nerve morphogenesis (GO:0021602)2.83783712
109interferon-gamma secretion (GO:0072643)2.83545766
110RNA localization (GO:0006403)2.81944527
111meiotic cell cycle process (GO:1903046)2.80843108
112mitotic G1 DNA damage checkpoint (GO:0031571)2.77324258
113negative regulation of gene expression, epigenetic (GO:0045814)2.76951017
114cilium organization (GO:0044782)2.76185659
115microtubule-based movement (GO:0007018)2.74434266
116protein-DNA complex disassembly (GO:0032986)2.74413655
117nucleosome disassembly (GO:0006337)2.74413655
118positive regulation of endothelial cell differentiation (GO:0045603)2.73864852
119positive regulation of macrophage activation (GO:0043032)2.73409276
120NAD biosynthetic process (GO:0009435)2.70984337
121glomerular visceral epithelial cell development (GO:0072015)2.70572157
122RNA destabilization (GO:0050779)2.69977357
123regulation of cilium assembly (GO:1902017)2.68875667
124synapsis (GO:0007129)2.66376620
125chromatin silencing (GO:0006342)2.65273013
126cilium assembly (GO:0042384)2.65122416
127lactate metabolic process (GO:0006089)2.64188130
128cellular component assembly involved in morphogenesis (GO:0010927)2.62335088
129UTP biosynthetic process (GO:0006228)2.62187011
130cilium morphogenesis (GO:0060271)2.59546575
131intraciliary transport (GO:0042073)2.56593344
132negative regulation of organelle assembly (GO:1902116)2.55234243
133axoneme assembly (GO:0035082)2.55172544
134mitochondrion degradation (GO:0000422)2.53277622
135positive regulation of glycolytic process (GO:0045821)2.47084500
136glycerol metabolic process (GO:0006071)2.44425601
137sperm motility (GO:0030317)14.4594313
138fusion of sperm to egg plasma membrane (GO:0007342)13.6694670
139cell wall macromolecule catabolic process (GO:0016998)12.5570074
140cell wall macromolecule metabolic process (GO:0044036)12.5570074
141acrosome reaction (GO:0007340)12.2616602
142sperm-egg recognition (GO:0035036)11.5144551
143acrosome assembly (GO:0001675)11.4744670
144multicellular organism reproduction (GO:0032504)10.9157350
145binding of sperm to zona pellucida (GO:0007339)10.5106963
146plasma membrane fusion (GO:0045026)10.4158144
147cell-cell recognition (GO:0009988)10.3023017
148epithelial cilium movement (GO:0003351)10.0131286

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.18316766
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.71007101
3EZH2_22144423_ChIP-Seq_EOC_Human4.25290440
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.04326849
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.58170466
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.33539600
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.30548305
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.86123895
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.79108892
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.66832135
11VDR_22108803_ChIP-Seq_LS180_Human2.52380262
12CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.28745751
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.28739201
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.13892694
15GATA1_26923725_Chip-Seq_HPCs_Mouse2.12879622
16VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.12872634
17ELF1_20517297_ChIP-Seq_JURKAT_Human2.10654791
18EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.04722441
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.04149822
20ZNF274_21170338_ChIP-Seq_K562_Hela2.01119267
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98915500
22DROSHA_22980978_ChIP-Seq_HELA_Human1.91457395
23ERA_21632823_ChIP-Seq_H3396_Human1.90710387
24RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.89521457
25RAC3_21632823_ChIP-Seq_H3396_Human1.88245492
26EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.86673305
27FUS_26573619_Chip-Seq_HEK293_Human1.83471700
28KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.82211161
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.79757694
30STAT1_17558387_ChIP-Seq_HELA_Human1.76018201
31FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75137191
32ELK4_26923725_Chip-Seq_MESODERM_Mouse1.73254464
33TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.70996547
34MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.69501712
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66724043
36SOX2_22085726_ChIP-Seq_NPCs_Mouse1.65925714
37CTCF_27219007_Chip-Seq_Bcells_Human1.64821150
38MYC_19829295_ChIP-Seq_ESCs_Human1.62542117
39BCL6_27268052_Chip-Seq_Bcells_Human1.62145974
40TAF2_19829295_ChIP-Seq_ESCs_Human1.62026175
41E2F1_20622854_ChIP-Seq_HELA_Human1.61068510
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60993616
43ER_23166858_ChIP-Seq_MCF-7_Human1.59817850
44WDR5_24793694_ChIP-Seq_LNCAP_Human1.56671206
45GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.55472244
46PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.54607626
47GATA3_21867929_ChIP-Seq_CD8_Mouse1.53131903
48SMAD4_21741376_ChIP-Seq_EPCs_Human1.52842258
49RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.52385753
50SMC4_20622854_ChIP-Seq_HELA_Human1.52367907
51ARNT_22903824_ChIP-Seq_MCF-7_Human1.52238774
52OCT4_20526341_ChIP-Seq_ESCs_Human1.51245261
53PHF8_20622854_ChIP-Seq_HELA_Human1.47604805
54AUTS2_25519132_ChIP-Seq_293T-REX_Human1.47010163
55TDRD3_21172665_ChIP-Seq_MCF-7_Human1.47000083
56BCOR_27268052_Chip-Seq_Bcells_Human1.46991141
57AR_25329375_ChIP-Seq_VCAP_Human1.46798581
58P68_20966046_ChIP-Seq_HELA_Human1.45855280
59HNFA_21074721_ChIP-Seq_CACO-2_Human1.45771271
60KDM2B_26808549_Chip-Seq_REH_Human1.45587242
61RBPJ_21746931_ChIP-Seq_IB4_Human1.43974580
62TAL1_26923725_Chip-Seq_HPCs_Mouse1.43167409
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42645013
64CBP_20019798_ChIP-Seq_JUKART_Human1.42645013
65* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.41352024
66ETV2_25802403_ChIP-Seq_MESCs_Mouse1.41206863
67FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.41094241
68CBX2_22325352_ChIP-Seq_293T-Rex_Human1.40269457
69CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.38475765
70ETV1_20927104_ChIP-Seq_GIST48_Human1.38290876
71PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.37043532
72TP63_22573176_ChIP-Seq_HFKS_Human1.36389439
73P53_21459846_ChIP-Seq_SAOS-2_Human1.35920860
74TP53_18474530_ChIP-ChIP_U2OS_Human1.35497603
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.33697109
76SMAD3_21741376_ChIP-Seq_ESCs_Human1.32774940
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.32655881
78LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.32642319
79CEBPB_22108803_ChIP-Seq_LS180_Human1.32295579
80P300_27268052_Chip-Seq_Bcells_Human1.31294140
81SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31055646
82GATA3_21867929_ChIP-Seq_TH1_Mouse1.30862273
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28937334
84REST_21632747_ChIP-Seq_MESCs_Mouse1.28566847
85SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.27624440
86GATA3_21878914_ChIP-Seq_MCF-7_Human1.25794182
87NFE2_27457419_Chip-Seq_LIVER_Mouse1.25020477
88KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.23919342
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22486309
90P300_19829295_ChIP-Seq_ESCs_Human1.22188325
91GF1_26923725_Chip-Seq_HPCs_Mouse1.21972637
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21741905
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.21586824
94CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21279480
95PHF8_20622853_ChIP-Seq_HELA_Human1.20775934
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20488581
97RAD21_21589869_ChIP-Seq_MESCs_Mouse1.20208737
98CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20207814
99P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.20013761
100SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.19988182
101ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19820679
102PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18930586
103PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18877061
104CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17909419
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17845828
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17845828
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17841856
108SMRT_27268052_Chip-Seq_Bcells_Human1.17439368
109TAF15_26573619_Chip-Seq_HEK293_Human1.17215244
110SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16789987
111SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16346317
112TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15959408
113SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.15084717
114LXR_22292898_ChIP-Seq_THP-1_Human1.15072844
115GATA6_21074721_ChIP-Seq_CACO-2_Human1.14274649
116SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14199889
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14160878
118AR_21572438_ChIP-Seq_LNCaP_Human1.14093787
119SPI1_26923725_Chip-Seq_HPCs_Mouse1.12875494
120PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12256070
121ERG_20517297_ChIP-Seq_VCAP_Human1.12080962
122TP63_19390658_ChIP-ChIP_HaCaT_Human1.11683515
123RUNX_20019798_ChIP-Seq_JUKART_Human1.11488478
124RUNX2_22187159_ChIP-Seq_PCA_Human1.10776687
125SMAD4_21741376_ChIP-Seq_HESCs_Human1.10451349
126NFYA_21822215_ChIP-Seq_K562_Human1.09018801
127PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.08628756
128RUNX1_26923725_Chip-Seq_HPCs_Mouse1.08224342
129RXRA_24833708_ChIP-Seq_LIVER_Mouse1.07191807
130NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06419995
131GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.05729601
132SA1_27219007_Chip-Seq_Bcells_Human1.05709631
133CRX_20693478_ChIP-Seq_RETINA_Mouse1.05690266
134MYC_27129775_Chip-Seq_CORNEA_Mouse1.05443870
135NANOG_18555785_Chip-Seq_ESCs_Mouse1.05274732
136STAT3_23295773_ChIP-Seq_U87_Human1.04229594
137SMAD4_21799915_ChIP-Seq_A2780_Human1.03699776
138ESET_19884257_ChIP-Seq_ESCs_Mouse1.03573312
139* SOX2_19829295_ChIP-Seq_ESCs_Human1.02457306
140* NANOG_19829295_ChIP-Seq_ESCs_Human1.02457306
141OCT1_27270436_Chip-Seq_PROSTATE_Human1.02390774
142GATA1_19941827_ChIP-Seq_MEL86_Mouse1.02216148
143PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02022877
144TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01829443
145CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01703133
146EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01635640
147JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.01493013
148NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00071640
149RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99810592
150RARA_24833708_ChIP-Seq_LIVER_Mouse0.99343936
151YY1_22570637_ChIP-Seq_MALME-3M_Human0.98636344
152TET1_21451524_ChIP-Seq_MESCs_Mouse0.97268963
153SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95356736
154SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95152030
155CTCF_20526341_ChIP-Seq_ESCs_Human0.94476036
156OCT4_18555785_Chip-Seq_ESCs_Mouse0.94303346
157NFYB_21822215_ChIP-Seq_K562_Human0.94015826
158SOX11_22085726_ChIP-Seq_ESNs_Mouse0.93983322
159P53_22387025_ChIP-Seq_ESCs_Mouse0.92948676
160LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92889922
161PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92709258
162FLI1_21867929_ChIP-Seq_CD8_Mouse0.92080941
163MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91629963
164RNF2_27304074_Chip-Seq_NSC_Mouse0.90470325
165NANOG_20526341_ChIP-Seq_ESCs_Human0.89305209
166CMYC_18555785_Chip-Seq_ESCs_Mouse0.88699086
167STAT3_18555785_ChIP-Seq_MESCs_Mouse0.88628545
168EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88310594
169OCT4_21477851_ChIP-Seq_ESCs_Mouse0.88303922
170TBL1_22424771_ChIP-Seq_293T_Human0.87949698
171SOX9_26525672_Chip-Seq_HEART_Mouse0.87675508
172TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87593828

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.10838392
2MP0001929_abnormal_gametogenesis5.56732831
3MP0008877_abnormal_DNA_methylation3.99753304
4MP0002210_abnormal_sex_determination3.37075985
5MP0002161_abnormal_fertility/fecundity3.35405656
6MP0005670_abnormal_white_adipose3.02438106
7MP0001348_abnormal_lacrimal_gland2.90572367
8MP0001145_abnormal_male_reproductive2.85381248
9MP0000653_abnormal_sex_gland2.47602258
10MP0000678_abnormal_parathyroid_gland2.43913508
11MP0003718_maternal_effect2.41565945
12MP0002653_abnormal_ependyma_morphology2.28575818
13MP0005423_abnormal_somatic_nervous2.14633274
14MP0005410_abnormal_fertilization16.5892031
15MP0002132_abnormal_respiratory_system1.90547188
16MP0009053_abnormal_anal_canal1.74010652
17MP0005379_endocrine/exocrine_gland_phen1.67763805
18MP0001485_abnormal_pinna_reflex1.60585704
19MP0002822_catalepsy1.57242621
20MP0005310_abnormal_salivary_gland1.55662392
21MP0001486_abnormal_startle_reflex1.54456491
22MP0002160_abnormal_reproductive_system1.53611821
23MP0003646_muscle_fatigue1.45330196
24MP0005623_abnormal_meninges_morphology1.40951034
25MP0002249_abnormal_larynx_morphology1.40079577
26MP0002735_abnormal_chemical_nociception1.38090709
27MP0004233_abnormal_muscle_weight1.33741901
28MP0005451_abnormal_body_composition1.29223221
29MP0004510_myositis1.27035274
30MP0002282_abnormal_trachea_morphology1.22048062
31MP0001765_abnormal_ion_homeostasis1.18976668
32MP0004859_abnormal_synaptic_plasticity1.18283263
33MP0001963_abnormal_hearing_physiology1.12628152
34MP0002127_abnormal_cardiovascular_syste1.09700369
35MP0002138_abnormal_hepatobiliary_system1.07345490
36MP0005248_abnormal_Harderian_gland1.06755234
37MP0005395_other_phenotype1.02999842
38MP0000026_abnormal_inner_ear0.97369879
39MP0008995_early_reproductive_senescence0.96145715
40MP0005647_abnormal_sex_gland0.95941276
41MP0005167_abnormal_blood-brain_barrier0.94626572
42MP0000955_abnormal_spinal_cord0.94579387
43MP0001984_abnormal_olfaction0.91811403
44MP0002229_neurodegeneration0.89945853
45MP0008058_abnormal_DNA_repair0.87468117
46MP0001879_abnormal_lymphatic_vessel0.86991350
47MP0002733_abnormal_thermal_nociception0.83735033
48MP0000681_abnormal_thyroid_gland0.82033190
49MP0002234_abnormal_pharynx_morphology0.79597163
50MP0002067_abnormal_sensory_capabilities0.78643274
51MP0005389_reproductive_system_phenotype0.76713030
52MP0005377_hearing/vestibular/ear_phenot0.74835829
53MP0003878_abnormal_ear_physiology0.74835829
54MP0008569_lethality_at_weaning0.74249424
55MP0003115_abnormal_respiratory_system0.73350228
56MP0003880_abnormal_central_pattern0.72496140
57MP0000049_abnormal_middle_ear0.71024805
58MP0002557_abnormal_social/conspecific_i0.70593232
59MP0004085_abnormal_heartbeat0.69962919
60MP0009046_muscle_twitch0.69356595
61MP0001905_abnormal_dopamine_level0.68818030
62MP0005636_abnormal_mineral_homeostasis0.67920623
63MP0002272_abnormal_nervous_system0.67771568
64MP0005666_abnormal_adipose_tissue0.67014431
65MP0001666_abnormal_nutrient_absorption0.66812106
66MP0004484_altered_response_of0.66673770
67MP0001501_abnormal_sleep_pattern0.66154468
68MP0003119_abnormal_digestive_system0.65469668
69MP0005367_renal/urinary_system_phenotyp0.63825722
70MP0000516_abnormal_urinary_system0.63825722
71MP0003011_delayed_dark_adaptation0.62206713
72MP0002572_abnormal_emotion/affect_behav0.57751090
73MP0009745_abnormal_behavioral_response0.57392722
74MP0001970_abnormal_pain_threshold0.57101243
75MP0000613_abnormal_salivary_gland0.54277238
76MP0010094_abnormal_chromosome_stability0.54253603
77MP0001440_abnormal_grooming_behavior0.53638417
78MP0000569_abnormal_digit_pigmentation0.52836879
79MP0005408_hypopigmentation0.52197079
80MP0003699_abnormal_female_reproductive0.51398623
81MP0001764_abnormal_homeostasis0.51360834
82MP0004036_abnormal_muscle_relaxation0.50760705
83MP0003329_amyloid_beta_deposits0.50100296
84MP0009697_abnormal_copulation0.49532061
85MP0000358_abnormal_cell_content/0.49436890
86MP0001324_abnormal_eye_pigmentation0.48777922
87MP0000249_abnormal_blood_vessel0.48421516
88MP0000003_abnormal_adipose_tissue0.48263932
89MP0005083_abnormal_biliary_tract0.47949692
90MP0005397_hematopoietic_system_phenotyp0.46544302
91MP0001545_abnormal_hematopoietic_system0.46544302
92MP0001293_anophthalmia0.44976783
93MP0003111_abnormal_nucleus_morphology0.44570870
94MP0002269_muscular_atrophy0.44502205
95MP0002734_abnormal_mechanical_nocicepti0.44265858
96MP0002736_abnormal_nociception_after0.43489863
97MP0005535_abnormal_body_temperature0.43150499
98MP0003137_abnormal_impulse_conducting0.40925765
99MP0003635_abnormal_synaptic_transmissio0.40376219
100MP0009115_abnormal_fat_cell0.40077541
101MP0000470_abnormal_stomach_morphology0.39311163
102MP0009278_abnormal_bone_marrow0.38897179
103MP0003950_abnormal_plasma_membrane0.38885827
104MP0002928_abnormal_bile_duct0.38576235
105MP0006276_abnormal_autonomic_nervous0.38297250
106MP0000534_abnormal_ureter_morphology0.38290127
107MP0010368_abnormal_lymphatic_system0.37525488
108MP0003936_abnormal_reproductive_system0.36946298
109MP0009764_decreased_sensitivity_to0.36705682
110MP0005253_abnormal_eye_physiology0.36348750
111MP0000230_abnormal_systemic_arterial0.36050425
112MP0005551_abnormal_eye_electrophysiolog0.34692680
113MP0006292_abnormal_olfactory_placode0.33830262
114MP0006036_abnormal_mitochondrial_physio0.33644100
115MP0001730_embryonic_growth_arrest0.33375418
116MP0003786_premature_aging0.33172529
117MP0010329_abnormal_lipoprotein_level0.32937822
118MP0002971_abnormal_brown_adipose0.31681352
119MP0001119_abnormal_female_reproductive0.30760251
120MP0008007_abnormal_cellular_replicative0.30583156
121MP0005391_vision/eye_phenotype0.30060808
122MP0003879_abnormal_hair_cell0.29112969
123MP0008057_abnormal_DNA_replication0.28053782
124MP0002139_abnormal_hepatobiliary_system0.27907708
125MP0002102_abnormal_ear_morphology0.27603315
126MP0003942_abnormal_urinary_system0.27534089
127MP0001849_ear_inflammation0.26075793
128MP0004019_abnormal_vitamin_homeostasis0.25298974
129MP0003861_abnormal_nervous_system0.24148366
130MP0010307_abnormal_tumor_latency0.24000075
131MP0001727_abnormal_embryo_implantation0.23570314
132MP0000604_amyloidosis0.23515454
133MP0004811_abnormal_neuron_physiology0.23263453
134MP0003633_abnormal_nervous_system0.22791645
135MP0002169_no_abnormal_phenotype0.22771402
136MP0002873_normal_phenotype0.22510427
137MP0005375_adipose_tissue_phenotype0.22067480
138MP0004133_heterotaxia0.21936065
139MP0001968_abnormal_touch/_nociception0.21198489
140MP0003948_abnormal_gas_homeostasis0.21000549
141MP0002152_abnormal_brain_morphology0.19957483
142MP0004742_abnormal_vestibular_system0.19666525
143MP0002295_abnormal_pulmonary_circulatio0.18862621
144MP0003631_nervous_system_phenotype0.18635086
145MP0002092_abnormal_eye_morphology0.18469571
146MP0008961_abnormal_basal_metabolism0.18323255
147MP0002084_abnormal_developmental_patter0.17074923
148MP0004270_analgesia0.16165037
149MP0001672_abnormal_embryogenesis/_devel0.15695152
150MP0005380_embryogenesis_phenotype0.15695152
151MP0006035_abnormal_mitochondrial_morpho0.15437781
152MP0000313_abnormal_cell_death0.15388583
153MP0009672_abnormal_birth_weight0.15042005
154MP0001661_extended_life_span0.14832551
155MP0000751_myopathy0.14549730
156MP0004145_abnormal_muscle_electrophysio0.14439049
157MP0005365_abnormal_bile_salt0.14349209
158MP0004043_abnormal_pH_regulation0.14244181
159MP0000001_mammalian_phenotype0.14224808
160MP0003077_abnormal_cell_cycle0.13810865
161MP0002693_abnormal_pancreas_physiology0.13353353
162MP0003787_abnormal_imprinting0.13080492
163MP0001697_abnormal_embryo_size0.13017001
164MP0000462_abnormal_digestive_system0.12985131

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.36699769
2Abnormal respiratory motile cilium morphology (HP:0005938)9.36699769
3Abnormal respiratory motile cilium physiology (HP:0012261)9.34507188
4Severe visual impairment (HP:0001141)8.26820103
5Abnormal ciliary motility (HP:0012262)7.45139177
6Rhinitis (HP:0012384)7.37222369
7Chronic bronchitis (HP:0004469)7.29942188
8Infertility (HP:0000789)7.07954102
9Nasal polyposis (HP:0100582)6.32067643
10Attenuation of retinal blood vessels (HP:0007843)5.29424695
11Abnormality of the nasal mucosa (HP:0000433)5.19472090
12Bony spicule pigmentary retinopathy (HP:0007737)5.17488752
13Male infertility (HP:0003251)5.16216583
14Resting tremor (HP:0002322)4.74682301
15Bronchitis (HP:0012387)4.58747126
16Chronic hepatic failure (HP:0100626)4.46344662
17Hyperkalemia (HP:0002153)4.43080810
18Bronchiectasis (HP:0002110)4.36407514
19Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.27253689
20Abnormality of macular pigmentation (HP:0008002)4.26103830
21Hypoplastic ischia (HP:0003175)4.16922301
22Nephronophthisis (HP:0000090)4.07985897
23Abnormal rod and cone electroretinograms (HP:0008323)4.02911823
24Enlarged epiphyses (HP:0010580)3.95519876
25Potter facies (HP:0002009)3.93355545
26Facial shape deformation (HP:0011334)3.93355545
27Abnormal spermatogenesis (HP:0008669)3.80360594
28Aplasia/Hypoplasia of the earlobes (HP:0009906)3.75847989
29Cone-rod dystrophy (HP:0000548)3.74066576
30Abnormality of the ischium (HP:0003174)3.69583892
31Recurrent sinusitis (HP:0011108)3.41988226
32Hypoplasia of the thymus (HP:0000778)3.37803942
33Recurrent otitis media (HP:0000403)3.30408601
34Postural instability (HP:0002172)3.20258431
35Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.14217209
36Abnormality of the renal medulla (HP:0100957)3.07332986
37Unilateral renal agenesis (HP:0000122)3.00342416
38Abnormality of the costochondral junction (HP:0000919)2.89995923
39Tubulointerstitial nephritis (HP:0001970)2.84928128
40Progressive sensorineural hearing impairment (HP:0000408)2.81533584
41Impulsivity (HP:0100710)2.79816593
42Recurrent bronchitis (HP:0002837)2.77950418
43Abnormality of the aortic arch (HP:0012303)2.75431049
44Amelogenesis imperfecta (HP:0000705)2.72507770
45Progressive cerebellar ataxia (HP:0002073)2.71149215
46Hypoalphalipoproteinemia (HP:0003233)2.67907841
47Generalized aminoaciduria (HP:0002909)2.65963015
48Portal hypertension (HP:0001409)2.56056657
49Abnormality of potassium homeostasis (HP:0011042)2.55233127
50Tubular atrophy (HP:0000092)2.53699635
51Abnormality of midbrain morphology (HP:0002418)2.49059285
52Molar tooth sign on MRI (HP:0002419)2.49059285
53Abnormality of the parathyroid morphology (HP:0011766)2.44856419
54Ventricular tachycardia (HP:0004756)2.43952945
55Abnormal gallbladder physiology (HP:0012438)2.43825905
56Cholecystitis (HP:0001082)2.43825905
57Epiphyseal dysplasia (HP:0002656)2.43535612
58Tubulointerstitial abnormality (HP:0001969)2.39947042
59Menstrual irregularities (HP:0000858)2.37119951
60Gonadotropin excess (HP:0000837)2.36408712
61Abnormality of dental color (HP:0011073)2.35650986
62Abnormality of the hepatic vasculature (HP:0006707)2.33449140
63Azoospermia (HP:0000027)2.32403078
64Renovascular hypertension (HP:0100817)2.24824030
65Insulin-resistant diabetes mellitus (HP:0000831)2.23147874
66Medial flaring of the eyebrow (HP:0010747)2.20826754
67Polyuria (HP:0000103)2.19943539
68Dyschromatopsia (HP:0007641)2.19715341
69Hypophosphatemic rickets (HP:0004912)2.19008424
70Widely patent fontanelles and sutures (HP:0004492)2.18974342
71Abnormality of the pubic bones (HP:0003172)2.09331696
72Osteomalacia (HP:0002749)2.07493038
73Tetany (HP:0001281)2.05414315
74Abnormality of the epiphysis of the femoral head (HP:0010574)2.04640516
75Horizontal nystagmus (HP:0000666)2.02987646
76Spastic tetraparesis (HP:0001285)2.00602299
77Dynein arm defect of respiratory motile cilia (HP:0012255)13.7285068
78Absent/shortened dynein arms (HP:0200106)13.7285068
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9780585
80Hyponatremia (HP:0002902)1.97403894
81Flattened epiphyses (HP:0003071)1.96916061
82Pendular nystagmus (HP:0012043)1.95460121
83Choroideremia (HP:0001139)1.93518477
84Decreased central vision (HP:0007663)1.92941916
85Recurrent pneumonia (HP:0006532)1.92706040
86Myokymia (HP:0002411)1.92322073
87Bradycardia (HP:0001662)1.91213020
88Abnormality of femoral epiphyses (HP:0006499)1.90793318
89Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.90793318
90Tubulointerstitial fibrosis (HP:0005576)1.90688306
91Intellectual disability, moderate (HP:0002342)1.89700780
92Recurrent corneal erosions (HP:0000495)1.86446361
93Progressive hearing impairment (HP:0001730)1.86147714
94Spastic paraparesis (HP:0002313)1.81690217
95Hyperuricemia (HP:0002149)1.81248596
96Increased purine levels (HP:0004368)1.81248596
97Abnormality of the femoral head (HP:0003368)1.80564020
98Heterotopia (HP:0002282)1.79489809
99Renal Fanconi syndrome (HP:0001994)1.77168699
100Hyperthyroidism (HP:0000836)1.75485946
101Photophobia (HP:0000613)1.75348615
102Abnormal connection of the cardiac segments (HP:0011545)1.74974930
103Postaxial foot polydactyly (HP:0001830)1.73588760
104Hemorrhage of the eye (HP:0011885)1.72854008
105Stage 5 chronic kidney disease (HP:0003774)1.70472925
106Abnormal biliary tract physiology (HP:0012439)1.69875037
107Bile duct proliferation (HP:0001408)1.69875037
108Abnormal drinking behavior (HP:0030082)1.67384789
109Polydipsia (HP:0001959)1.67384789
110Abnormality of renal excretion (HP:0011036)1.60557950
111Congenital hepatic fibrosis (HP:0002612)1.58721990
112Abnormality of the renal cortex (HP:0011035)1.58372950
113Hypoplasia of the capital femoral epiphysis (HP:0003090)1.57515015
114Short ribs (HP:0000773)1.55420444
115Asymmetric septal hypertrophy (HP:0001670)1.54896984
116Bell-shaped thorax (HP:0001591)1.53380552
117Neurofibrillary tangles (HP:0002185)1.50906119
118Decreased electroretinogram (ERG) amplitude (HP:0000654)1.50811971
119Congenital malformation of the right heart (HP:0011723)1.50107529
120Double outlet right ventricle (HP:0001719)1.50107529
121Abnormality of the dental root (HP:0006486)1.49901552
122Taurodontia (HP:0000679)1.49901552
123Abnormality of permanent molar morphology (HP:0011071)1.49901552
124Oculomotor apraxia (HP:0000657)1.47580598
125Bundle branch block (HP:0011710)1.46727446
126Fibular hypoplasia (HP:0003038)1.43641559
127Abnormality of the lower motor neuron (HP:0002366)1.43569658
128Abnormality of dentin (HP:0010299)1.42454358
129Abnormality of the dental pulp (HP:0006479)1.39159684
130Abnormality of molar morphology (HP:0011070)1.37879782
131Abnormality of molar (HP:0011077)1.37879782
132Cystic liver disease (HP:0006706)1.36136318
133Aplasia/Hypoplasia of the lens (HP:0008063)1.35737323
134Postaxial hand polydactyly (HP:0001162)1.34491103
135Renal dysplasia (HP:0000110)1.33960233
136Abnormal urine output (HP:0012590)1.32502630
137Deformed sella turcica (HP:0002681)1.31465136
138Constricted visual fields (HP:0001133)1.27861424
139Facial cleft (HP:0002006)1.27767625
140Hemiparesis (HP:0001269)1.25404211
141Cerebral inclusion bodies (HP:0100314)1.25343974
142Amyotrophic lateral sclerosis (HP:0007354)1.25230973
143Exercise-induced myalgia (HP:0003738)1.24530599
144Easy fatigability (HP:0003388)1.23620680
145Absent epiphyses (HP:0010577)1.22849229
146Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.22849229
147Absent frontal sinuses (HP:0002688)1.22636069
148Hypercholesterolemia (HP:0003124)1.22083060
149Broad distal phalanx of finger (HP:0009836)1.22001729
150Microglossia (HP:0000171)1.21203396
151Pancreatic fibrosis (HP:0100732)1.21017439
152Sensory axonal neuropathy (HP:0003390)1.20284811
153Chronic sinusitis (HP:0011109)1.19444395
154Truncal obesity (HP:0001956)1.19061881
155Myoglobinuria (HP:0002913)1.18376401
156Abnormality of the neuromuscular junction (HP:0003398)1.16420846
157Fatigable weakness (HP:0003473)1.16420846
158Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.14371453
159Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.13215620
160Rhabdomyolysis (HP:0003201)1.12156064
161Aplasia/Hypoplasia of the tongue (HP:0010295)1.11835567
162J-shaped sella turcica (HP:0002680)1.11424212
163Nephropathy (HP:0000112)1.10971561
164Congenital primary aphakia (HP:0007707)1.10833263

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.20318088
2PDK48.20318088
3TESK16.15851862
4PDK25.31140657
5PRKD35.19453435
6DDR25.03884751
7ICK4.47958581
8INSRR3.70512633
9PLK23.21960633
10BRD43.09593967
11MAP4K22.60119152
12PTK2B2.20231024
13WNK42.11614768
14PNCK2.06931893
15STK391.99605168
16PIK3CG1.84878422
17STK381.82796344
18DYRK1B1.66094465
19NEK21.61672533
20MST1R1.56828445
21FRK1.35667216
22CDK71.32065080
23PDK11.20649696
24AKT31.12200401
25MAP3K91.08803239
26DYRK31.00308735
27TYRO30.93785331
28KSR20.87299867
29WNK10.82337679
30MAPK150.82196298
31MAP2K20.75581480
32PDPK10.74594067
33RPS6KA20.71779171
34UHMK10.70623684
35MAP3K20.69363068
36CAMK1D0.69323911
37PASK0.68306788
38IRAK10.68207058
39STK30.67155612
40RIPK40.66994197
41TTK0.65873615
42MAP3K110.65870311
43CAMK1G0.65514714
44EEF2K0.65463430
45TESK20.63618136
46CAMK10.63598763
47CCNB10.63567353
48MAP2K60.63199408
49SIK20.62095013
50ACVR1B0.61603949
51PRKAA20.60383097
52CHEK20.60329154
53LATS20.58105899
54STK38L0.54795884
55PINK10.52430364
56BMPR1B0.45388849
57PAK10.44677041
58ROCK10.44418088
59LMTK20.44153931
60MAP3K80.43808787
61MAPK10.43087107
62RPS6KL10.43041488
63RPS6KC10.43041488
64CHEK10.42538890
65RPS6KA60.40941132
66SGK2230.40051389
67SGK4940.40051389
68MUSK0.39888680
69CAMK40.39604328
70NTRK20.39433982
71NTRK30.38765649
72PAK20.34269096
73IRAK20.33625982
74PRKCG0.33211370
75MET0.30872117
76WEE10.30267270
77MAP3K100.29397198
78ATM0.29266931
79SGK10.28685125
80PLK40.28014684
81MTOR0.27890132
82MARK20.27506630
83MARK10.26940036
84CDK190.26367703
85PAK40.24534330
86MAP3K40.24429639
87CDC70.24419041
88MAPKAPK50.24248719
89ATR0.23586436
90NEK60.23435991
91OXSR10.23060326
92MAPK140.22703881
93BRSK20.22532820
94CAMKK10.21463159
95PRKAA10.21404257
96JAK30.19401695
97TIE10.18629618
98PLK10.17369656
99PRKCZ0.17165988
100MAPK100.16801092
101FER0.15709018
102CDK150.15257746
103ADRBK20.14938174
104AKT10.13968009
105ZAK0.13731810
106MAPK110.13512838
107PRKCE0.13289755
108BRSK10.13031382
109PRKACA0.13018189
110RPS6KB10.12713009
111CDK180.12410281
112PRKCQ0.11734393
113CDK11A0.11604031
114CDK120.11316952
115BRAF0.10908514
116IKBKB0.09241319
117MARK30.09077544
118ARAF0.08619095
119SGK20.08619084
120GSK3B0.08258269
121CDK140.07182287
122MAP3K70.07164215
123CSNK2A10.06977206
124MAP3K130.06826662
125CSNK1D0.06711622
126RPS6KA10.06685381
127PRKG20.06607208
128CDK60.06316016
129STK100.06133738
130PAK60.05465282
131CDK20.05452432
132CDK10.04862461
133CDK40.03030289
134PIM10.02621857
135PRKG10.02244027
136CSNK2A20.02143008
137MAPK80.02109580
138STK110.01988626
139PRKACG0.01928978
140CAMK2A0.01312701
141CDK30.00812288
142PRKCB0.00731661
143MAP3K50.00536563
144CSF1R0.00365998
145PKN10.00084483
146MAP3K1-0.0305693
147PRKDC-0.0288891
148EGFR-0.0282581
149PDGFRB-0.0270358
150PRKACB-0.0231946
151RPS6KA3-0.0187819
152WNK3-0.0078083
153PRKCA-0.0074099
154AURKA-0.0068183
155PRKCD-0.0018403
156LATS1-0.0015769

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.55131311
2Fatty acid biosynthesis_Homo sapiens_hsa000614.70367058
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.60792803
4Olfactory transduction_Homo sapiens_hsa047404.06325804
5Vitamin B6 metabolism_Homo sapiens_hsa007503.77523096
6Pyruvate metabolism_Homo sapiens_hsa006203.37900705
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.05513081
8Linoleic acid metabolism_Homo sapiens_hsa005912.93834042
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.84590923
10Butanoate metabolism_Homo sapiens_hsa006502.83493013
11Propanoate metabolism_Homo sapiens_hsa006402.58892417
12Glucagon signaling pathway_Homo sapiens_hsa049222.56709318
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.46567500
14Carbohydrate digestion and absorption_Homo sapiens_hsa049732.40662189
15Basal transcription factors_Homo sapiens_hsa030222.26154603
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.11134738
17Glycerolipid metabolism_Homo sapiens_hsa005611.96085628
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.92656836
19PPAR signaling pathway_Homo sapiens_hsa033201.90999855
20Selenocompound metabolism_Homo sapiens_hsa004501.88301672
21Glycerophospholipid metabolism_Homo sapiens_hsa005641.69713694
22Oocyte meiosis_Homo sapiens_hsa041141.67776393
23Fructose and mannose metabolism_Homo sapiens_hsa000511.64603576
24Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.63011044
25Pentose phosphate pathway_Homo sapiens_hsa000301.59647936
26Mineral absorption_Homo sapiens_hsa049781.58127884
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.50230533
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.47854757
29Dorso-ventral axis formation_Homo sapiens_hsa043201.46900960
30Type I diabetes mellitus_Homo sapiens_hsa049401.46266957
31Phenylalanine metabolism_Homo sapiens_hsa003601.45575050
32Fatty acid degradation_Homo sapiens_hsa000711.43324522
33Type II diabetes mellitus_Homo sapiens_hsa049301.43125328
34Amphetamine addiction_Homo sapiens_hsa050311.42720832
35Fatty acid metabolism_Homo sapiens_hsa012121.42016527
36Allograft rejection_Homo sapiens_hsa053301.41081413
37Fat digestion and absorption_Homo sapiens_hsa049751.38703490
38Carbon metabolism_Homo sapiens_hsa012001.37146599
39Ether lipid metabolism_Homo sapiens_hsa005651.35195992
40Autoimmune thyroid disease_Homo sapiens_hsa053201.29869944
41Arginine and proline metabolism_Homo sapiens_hsa003301.29689988
42Graft-versus-host disease_Homo sapiens_hsa053321.23568587
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.23238355
44Fanconi anemia pathway_Homo sapiens_hsa034601.22715197
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21406927
46Cardiac muscle contraction_Homo sapiens_hsa042601.21266566
47Phototransduction_Homo sapiens_hsa047441.16326655
48Antigen processing and presentation_Homo sapiens_hsa046121.12031093
49mRNA surveillance pathway_Homo sapiens_hsa030151.06831463
50Purine metabolism_Homo sapiens_hsa002301.05575962
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03237545
52Renin secretion_Homo sapiens_hsa049241.02754150
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98231588
54Biosynthesis of amino acids_Homo sapiens_hsa012300.96120298
55Viral myocarditis_Homo sapiens_hsa054160.95295840
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94345896
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93698578
58Glutathione metabolism_Homo sapiens_hsa004800.93632548
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92774322
60RNA transport_Homo sapiens_hsa030130.92434375
61Hedgehog signaling pathway_Homo sapiens_hsa043400.89453204
62Collecting duct acid secretion_Homo sapiens_hsa049660.88169947
63Huntingtons disease_Homo sapiens_hsa050160.87395886
64Morphine addiction_Homo sapiens_hsa050320.86260330
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.83000349
66Nicotine addiction_Homo sapiens_hsa050330.81304719
67Insulin secretion_Homo sapiens_hsa049110.80952977
68Arachidonic acid metabolism_Homo sapiens_hsa005900.79400295
69Chemical carcinogenesis_Homo sapiens_hsa052040.78246026
70Arginine biosynthesis_Homo sapiens_hsa002200.77344815
71Bile secretion_Homo sapiens_hsa049760.77032444
72Thyroid hormone synthesis_Homo sapiens_hsa049180.76524062
73Estrogen signaling pathway_Homo sapiens_hsa049150.73073287
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.72824015
75Long-term potentiation_Homo sapiens_hsa047200.68571274
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67130715
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64704779
78Glutamatergic synapse_Homo sapiens_hsa047240.63608674
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.60824369
80Tyrosine metabolism_Homo sapiens_hsa003500.60722712
81Influenza A_Homo sapiens_hsa051640.58389029
82Legionellosis_Homo sapiens_hsa051340.57086901
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55926703
84Pancreatic secretion_Homo sapiens_hsa049720.52004476
85Salivary secretion_Homo sapiens_hsa049700.51593537
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.51419879
87Retinol metabolism_Homo sapiens_hsa008300.51235582
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50648389
89Protein digestion and absorption_Homo sapiens_hsa049740.50561138
90Renin-angiotensin system_Homo sapiens_hsa046140.49751148
91ABC transporters_Homo sapiens_hsa020100.46896053
92Calcium signaling pathway_Homo sapiens_hsa040200.46763359
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46435076
94Serotonergic synapse_Homo sapiens_hsa047260.45835057
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44571797
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44449661
97AMPK signaling pathway_Homo sapiens_hsa041520.44259810
98Inositol phosphate metabolism_Homo sapiens_hsa005620.43417394
99Endocytosis_Homo sapiens_hsa041440.43288636
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.41503900
101Cholinergic synapse_Homo sapiens_hsa047250.41182750
102Tight junction_Homo sapiens_hsa045300.40968392
103Synaptic vesicle cycle_Homo sapiens_hsa047210.40458869
104Nitrogen metabolism_Homo sapiens_hsa009100.40416770
105Gastric acid secretion_Homo sapiens_hsa049710.40156014
106GABAergic synapse_Homo sapiens_hsa047270.39970956
107MAPK signaling pathway_Homo sapiens_hsa040100.39224491
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38118427
109Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38092876
110Metabolic pathways_Homo sapiens_hsa011000.36331093
111Pyrimidine metabolism_Homo sapiens_hsa002400.36323090
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35989323
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34819673
114VEGF signaling pathway_Homo sapiens_hsa043700.34454641
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34258406
116ECM-receptor interaction_Homo sapiens_hsa045120.33591053
117cAMP signaling pathway_Homo sapiens_hsa040240.31693901
118Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30335261
119Sulfur metabolism_Homo sapiens_hsa009200.28772127
120Taste transduction_Homo sapiens_hsa047420.28519233
121Acute myeloid leukemia_Homo sapiens_hsa052210.26835760
122Tryptophan metabolism_Homo sapiens_hsa003800.26157770
123Systemic lupus erythematosus_Homo sapiens_hsa053220.25323373
124Prolactin signaling pathway_Homo sapiens_hsa049170.23644159
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23114512
126Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21665848
127Viral carcinogenesis_Homo sapiens_hsa052030.20281022
128Circadian entrainment_Homo sapiens_hsa047130.19982502
129Jak-STAT signaling pathway_Homo sapiens_hsa046300.19826788
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.19711804
131Steroid hormone biosynthesis_Homo sapiens_hsa001400.18884679
132Oxytocin signaling pathway_Homo sapiens_hsa049210.18873053
133beta-Alanine metabolism_Homo sapiens_hsa004100.17184558
134Cocaine addiction_Homo sapiens_hsa050300.16651993
135Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15876593
136HIF-1 signaling pathway_Homo sapiens_hsa040660.09714923
137Alcoholism_Homo sapiens_hsa050340.08636764
138Wnt signaling pathway_Homo sapiens_hsa043100.08620807
139B cell receptor signaling pathway_Homo sapiens_hsa046620.06653945
140Cell cycle_Homo sapiens_hsa041100.05678173
141RNA degradation_Homo sapiens_hsa030180.05630620
142Basal cell carcinoma_Homo sapiens_hsa052170.05579837
143Insulin resistance_Homo sapiens_hsa049310.03200089

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