SQLE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* cholesterol biosynthetic process (GO:0006695)8.71172933
2* sterol biosynthetic process (GO:0016126)7.70270743
3fatty acid elongation (GO:0030497)7.32848530
4axon ensheathment in central nervous system (GO:0032291)6.49393410
5central nervous system myelination (GO:0022010)6.49393410
6isoprenoid biosynthetic process (GO:0008299)5.94040896
7long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)5.73192867
8establishment of mitochondrion localization (GO:0051654)5.31920369
9pyrimidine nucleobase catabolic process (GO:0006208)5.14376808
10fatty-acyl-CoA biosynthetic process (GO:0046949)5.02035977
11long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.80389763
12response to lipoprotein particle (GO:0055094)4.33708359
13ensheathment of neurons (GO:0007272)4.23364508
14axon ensheathment (GO:0008366)4.23364508
15nuclear pore complex assembly (GO:0051292)4.23228928
16myelination (GO:0042552)4.19971352
17long-chain fatty acid biosynthetic process (GO:0042759)4.14931457
18apical protein localization (GO:0045176)4.13459513
19acyl-CoA biosynthetic process (GO:0071616)4.08857243
20thioester biosynthetic process (GO:0035384)4.08857243
21mitochondrion transport along microtubule (GO:0047497)4.03741098
22establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.03741098
23fatty-acyl-CoA metabolic process (GO:0035337)3.99962308
24nuclear pore organization (GO:0006999)3.89190713
25cellular response to cholesterol (GO:0071397)3.82359752
26nucleobase catabolic process (GO:0046113)3.81971841
27asymmetric protein localization (GO:0008105)3.75156139
28DNA unwinding involved in DNA replication (GO:0006268)3.73651708
29response to methylmercury (GO:0051597)3.66723097
30DNA topological change (GO:0006265)3.62342772
31* cholesterol metabolic process (GO:0008203)3.57216491
32myelin maintenance (GO:0043217)3.49087575
33sister chromatid segregation (GO:0000819)3.44902813
34mitotic sister chromatid segregation (GO:0000070)3.39758344
35protein localization to kinetochore (GO:0034501)3.36530767
36very long-chain fatty acid metabolic process (GO:0000038)3.34378621
37establishment of integrated proviral latency (GO:0075713)3.29097419
38* sterol metabolic process (GO:0016125)3.28375624
39mitotic metaphase plate congression (GO:0007080)3.27631369
40limb bud formation (GO:0060174)3.25904099
41negative regulation of neurotransmitter transport (GO:0051589)3.20089874
42mitotic chromosome condensation (GO:0007076)3.19782231
43regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.17123547
44* alcohol biosynthetic process (GO:0046165)3.15886148
45regulation of collateral sprouting (GO:0048670)3.14593460
46L-serine metabolic process (GO:0006563)3.10933562
47protein localization to chromosome, centromeric region (GO:0071459)3.10922468
48dendrite morphogenesis (GO:0048813)3.09886380
49pore complex assembly (GO:0046931)3.09760764
50alpha-linolenic acid metabolic process (GO:0036109)3.08574624
51axonal fasciculation (GO:0007413)3.08561605
52negative regulation of neurotransmitter secretion (GO:0046929)3.06980942
53layer formation in cerebral cortex (GO:0021819)3.06967000
54regulation of translational fidelity (GO:0006450)3.04509416
55regulation of centriole replication (GO:0046599)3.04047816
56* steroid biosynthetic process (GO:0006694)3.04043323
57cellular response to sterol (GO:0036315)3.01467481
58DNA strand elongation involved in DNA replication (GO:0006271)2.98851618
59oligodendrocyte differentiation (GO:0048709)2.98259502
60cerebral cortex radially oriented cell migration (GO:0021799)2.97902123
61neuron cell-cell adhesion (GO:0007158)2.95660628
62CENP-A containing nucleosome assembly (GO:0034080)2.95372076
63chromatin remodeling at centromere (GO:0031055)2.95213021
64DNA strand elongation (GO:0022616)2.92198032
65coenzyme A metabolic process (GO:0015936)2.92083104
66detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.91857151
67detection of temperature stimulus involved in sensory perception (GO:0050961)2.91857151
68dendritic spine morphogenesis (GO:0060997)2.89024914
69negative regulation of axonogenesis (GO:0050771)2.87934610
70Golgi transport vesicle coating (GO:0048200)2.87809001
71COPI coating of Golgi vesicle (GO:0048205)2.87809001
72mitotic sister chromatid cohesion (GO:0007064)2.87771720
73substantia nigra development (GO:0021762)2.87015108
74metaphase plate congression (GO:0051310)2.86265708
75negative regulation of microtubule polymerization (GO:0031115)2.84174102
76response to follicle-stimulating hormone (GO:0032354)2.84082290
77peptidyl-arginine omega-N-methylation (GO:0035247)2.83596752
78DNA ligation (GO:0006266)2.83570234
79glycerophospholipid catabolic process (GO:0046475)2.80842500
80neuron recognition (GO:0008038)2.80176415
81cell migration in hindbrain (GO:0021535)2.78991413
82DNA replication-independent nucleosome assembly (GO:0006336)2.77948684
83DNA replication-independent nucleosome organization (GO:0034724)2.77948684
84eye photoreceptor cell differentiation (GO:0001754)2.76887937
85photoreceptor cell differentiation (GO:0046530)2.76887937
86heterochromatin organization (GO:0070828)2.76533162
87regulation of sister chromatid cohesion (GO:0007063)2.76173790
88ATP-dependent chromatin remodeling (GO:0043044)2.75685997
89astrocyte differentiation (GO:0048708)2.75258476
90erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.72868567
91L-phenylalanine catabolic process (GO:0006559)2.72868567
92positive regulation of oligodendrocyte differentiation (GO:0048714)2.72524193
93positive regulation of actin filament depolymerization (GO:0030836)2.70321874
94organelle transport along microtubule (GO:0072384)2.68511104
95regulation of cholesterol biosynthetic process (GO:0045540)2.68048777
96acetyl-CoA metabolic process (GO:0006084)2.67336415
97triglyceride biosynthetic process (GO:0019432)2.66398636
98peptidyl-arginine methylation (GO:0018216)2.64022181
99peptidyl-arginine N-methylation (GO:0035246)2.64022181
100axon development (GO:0061564)2.62799222
101coenzyme catabolic process (GO:0009109)2.62203442
102negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.62039827
103mitotic nuclear envelope disassembly (GO:0007077)2.60313448
104tRNA aminoacylation for protein translation (GO:0006418)2.60151696
105DNA replication checkpoint (GO:0000076)2.60145863
106central nervous system projection neuron axonogenesis (GO:0021952)2.59560429
107paraxial mesoderm development (GO:0048339)2.59003536
108formation of translation preinitiation complex (GO:0001731)2.58991577
109proline biosynthetic process (GO:0006561)2.58890409
110polarized epithelial cell differentiation (GO:0030859)2.58789926
111thioester metabolic process (GO:0035383)2.58255092
112acyl-CoA metabolic process (GO:0006637)2.58255092
113heme transport (GO:0015886)2.57943483
114neuroblast proliferation (GO:0007405)2.57470133
115cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.57239853
116DNA replication-dependent nucleosome assembly (GO:0006335)2.56830011
117DNA replication-dependent nucleosome organization (GO:0034723)2.56830011
118regulation of centrosome cycle (GO:0046605)2.56561548
119lens fiber cell development (GO:0070307)2.55398465
120double-strand break repair via nonhomologous end joining (GO:0006303)2.55353412
121non-recombinational repair (GO:0000726)2.55353412
122IMP biosynthetic process (GO:0006188)2.53193344
123amino acid activation (GO:0043038)2.52083163
124tRNA aminoacylation (GO:0043039)2.52083163
125neutral lipid biosynthetic process (GO:0046460)2.52068104
126acylglycerol biosynthetic process (GO:0046463)2.52068104
127DNA replication initiation (GO:0006270)2.51073314
128histone exchange (GO:0043486)2.50164257
129detection of temperature stimulus (GO:0016048)2.49553323
130peripheral nervous system axon ensheathment (GO:0032292)2.49280777
131myelination in peripheral nervous system (GO:0022011)2.49280777
132semaphorin-plexin signaling pathway (GO:0071526)2.48652682
133peptidyl-cysteine modification (GO:0018198)2.48535131
134negative regulation of axon extension (GO:0030517)2.48498672
135DNA damage response, detection of DNA damage (GO:0042769)2.48390561
136magnesium ion transport (GO:0015693)2.47706565
137response to cholesterol (GO:0070723)2.47607376
138histone arginine methylation (GO:0034969)2.46649427
139nuclear envelope disassembly (GO:0051081)2.45794831
140membrane disassembly (GO:0030397)2.45794831
141telomere maintenance via semi-conservative replication (GO:0032201)2.45742129
142protein localization to chromosome (GO:0034502)2.45535793
143protein palmitoylation (GO:0018345)2.45534028
144establishment of viral latency (GO:0019043)2.45179233
145mitotic spindle checkpoint (GO:0071174)2.45139429
146regulation of chromosome segregation (GO:0051983)2.44904630
147negative regulation of chromosome segregation (GO:0051985)2.44875558
148spindle checkpoint (GO:0031577)2.44541882
149purine nucleobase biosynthetic process (GO:0009113)2.41142339
150ER overload response (GO:0006983)2.40636064
151negative regulation of mitotic sister chromatid separation (GO:2000816)2.40555149
152negative regulation of sister chromatid segregation (GO:0033046)2.40555149
153negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.40555149
154negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.40555149
155negative regulation of mitotic sister chromatid segregation (GO:0033048)2.40555149
156iron coordination entity transport (GO:1901678)2.40068727
157DNA duplex unwinding (GO:0032508)2.39318945
158positive regulation of pseudopodium assembly (GO:0031274)2.38999019
159regulation of centrosome duplication (GO:0010824)2.38252393
160negative regulation of mRNA processing (GO:0050686)2.37817502
161regulation of RNA export from nucleus (GO:0046831)2.37775889
162glial cell differentiation (GO:0010001)2.37396687
163DNA geometric change (GO:0032392)2.36429570
164positive regulation of dendritic spine morphogenesis (GO:0061003)2.36052760
165chromosome condensation (GO:0030261)2.35544609
166regulation of cholesterol homeostasis (GO:2000188)2.34930031
167terpenoid biosynthetic process (GO:0016114)2.34880552
168kinetochore organization (GO:0051383)2.34258947
169protein complex localization (GO:0031503)2.33663278
170regulation of extent of cell growth (GO:0061387)2.33601073
171establishment of chromosome localization (GO:0051303)2.33275255
172chromosome segregation (GO:0007059)2.33098856
173negative regulation of DNA recombination (GO:0045910)2.32384817
174chondrocyte development (GO:0002063)2.32366867
175mitotic spindle organization (GO:0007052)2.32339129
176serine family amino acid biosynthetic process (GO:0009070)2.32172550
177* organic hydroxy compound biosynthetic process (GO:1901617)2.31887350
178nucleosome disassembly (GO:0006337)2.31255269
179protein-DNA complex disassembly (GO:0032986)2.31255269
180mitotic spindle assembly checkpoint (GO:0007094)2.31253252
181nucleobase biosynthetic process (GO:0046112)2.30320912
182pre-miRNA processing (GO:0031054)2.29977481
183L-phenylalanine metabolic process (GO:0006558)2.29580089
184erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.29580089
185positive regulation of protein depolymerization (GO:1901881)2.28809770
186astrocyte development (GO:0014002)2.28273132
187G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.27893628
188spindle assembly checkpoint (GO:0071173)2.27609481
189DNA conformation change (GO:0071103)2.25957873
190RNA-dependent DNA replication (GO:0006278)2.25491705
191DNA strand renaturation (GO:0000733)2.23869307
192negative regulation of mRNA metabolic process (GO:1903312)2.23692890
193regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.23473471

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.99250320
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.04241277
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.65305727
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.42901622
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.11830041
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.01356688
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.99368113
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.84886783
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.78578019
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.78450077
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.62776374
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.54680363
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.53046560
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.51949057
15* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.48912842
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.39933546
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.37598740
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33977281
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.25998048
20GBX2_23144817_ChIP-Seq_PC3_Human2.25435619
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.25183806
22OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.25119780
23AR_21572438_ChIP-Seq_LNCaP_Human2.22058703
24WT1_19549856_ChIP-ChIP_CCG9911_Human2.18728094
25MYCN_18555785_ChIP-Seq_MESCs_Mouse2.17750366
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12956934
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.12631410
28E2F1_21310950_ChIP-Seq_MCF-7_Human2.10404533
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.00681630
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98844961
31XRN2_22483619_ChIP-Seq_HELA_Human1.98178946
32ZFX_18555785_ChIP-Seq_MESCs_Mouse1.95203980
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.91059324
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90828076
35TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.83717050
36TP63_17297297_ChIP-ChIP_HaCaT_Human1.82702501
37ELK1_19687146_ChIP-ChIP_HELA_Human1.80539207
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.79716274
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78731263
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77390998
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.76761765
42DCP1A_22483619_ChIP-Seq_HELA_Human1.76602606
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.75895894
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74596976
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.72112951
46CLOCK_20551151_ChIP-Seq_293T_Human1.71368762
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.70565840
48* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.69896657
49TTF2_22483619_ChIP-Seq_HELA_Human1.65639538
50GABP_19822575_ChIP-Seq_HepG2_Human1.65109908
51PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.65028771
52SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.63700632
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63667591
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.61246885
55SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.60431344
56* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.57821116
57STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.57697174
58CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.56102003
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56031888
60JARID2_20064375_ChIP-Seq_MESCs_Mouse1.54104958
61SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.53891788
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52216591
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52168888
64EED_16625203_ChIP-ChIP_MESCs_Mouse1.50023966
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.49923250
66MTF2_20144788_ChIP-Seq_MESCs_Mouse1.49602317
67SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.48116693
68SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.47202317
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.44690217
70ZNF274_21170338_ChIP-Seq_K562_Hela1.44625104
71JARID2_20075857_ChIP-Seq_MESCs_Mouse1.43666318
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43070909
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42306309
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42146739
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40924592
76EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40924592
77ESR1_15608294_ChIP-ChIP_MCF-7_Human1.40367151
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.38531560
79SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.38378323
80FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37794352
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.37649172
82NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36837405
83EZH2_27294783_Chip-Seq_ESCs_Mouse1.36593477
84RNF2_27304074_Chip-Seq_ESCs_Mouse1.35890609
85NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35767187
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35537289
87WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35448120
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34988460
89OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.34355096
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.34164429
91NANOG_16153702_ChIP-ChIP_HESCs_Human1.33062469
92ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32425029
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31344560
94HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29842950
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29792933
96SOX2_16153702_ChIP-ChIP_HESCs_Human1.28726082
97* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.26849413
98EZH2_22144423_ChIP-Seq_EOC_Human1.25817085
99NANOG_21062744_ChIP-ChIP_HESCs_Human1.25752802
100KDM5A_27292631_Chip-Seq_BREAST_Human1.25719043
101CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.25055609
102RING1B_27294783_Chip-Seq_NPCs_Mouse1.24777139
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23659199
104SUZ12_27294783_Chip-Seq_ESCs_Mouse1.23123722
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22037805
106SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.21650281
107PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20801435
108NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20474719
109NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20474719
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20266009
111CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19343194
112* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18376584
113* SOX17_20123909_ChIP-Seq_XEN_Mouse1.16610396
114SOX2_21211035_ChIP-Seq_LN229_Gbm1.16309837
115POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15787949
116TP63_19390658_ChIP-ChIP_HaCaT_Human1.15557657
117ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14706429
118FUS_26573619_Chip-Seq_HEK293_Human1.14257296
119TAF15_26573619_Chip-Seq_HEK293_Human1.13927850
120REST_21632747_ChIP-Seq_MESCs_Mouse1.12859411
121TP53_18474530_ChIP-ChIP_U2OS_Human1.12296604
122CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.11309265
123STAT3_23295773_ChIP-Seq_U87_Human1.10093046
124NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09895732
125E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09123729
126ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08294215
127* POU3F1_26484290_ChIP-Seq_ESCss_Mouse1.08246974
128SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07506018
129HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07490794
130YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07200921
131PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06860987
132* REST_19997604_ChIP-ChIP_NEURONS_Mouse1.06774083
133* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06546652
134CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06431656
135FOXP3_21729870_ChIP-Seq_TREG_Human1.05643440
136P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05597481
137EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.05206224
138ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03608415
139ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03390419
140DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02016041
141* ZNF263_19887448_ChIP-Seq_K562_Human1.00677588
142GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00618264
143ERG_21242973_ChIP-ChIP_JURKAT_Human0.99881975
144* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99149099
145SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99101728
146ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.98937548
147RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98925823
148EOMES_21245162_ChIP-Seq_HESCs_Human0.98782850
149AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98454796
150PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98333807
151MYC_18940864_ChIP-ChIP_HL60_Human0.97097294
152SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97016969
153P300_19829295_ChIP-Seq_ESCs_Human0.96667834
154NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96264114
155CHD1_26751641_Chip-Seq_LNCaP_Human0.95905089
156POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95770390
157HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95663424
158CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95481372
159* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95329580
160HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94609659
161REST_18959480_ChIP-ChIP_MESCs_Mouse0.94583674
162JUN_21703547_ChIP-Seq_K562_Human0.94226077
163E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.94181010
164AHR_22903824_ChIP-Seq_MCF-7_Human0.92585061
165WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92512014
166AR_21909140_ChIP-Seq_LNCAP_Human0.92487083
167IGF1R_20145208_ChIP-Seq_DFB_Human0.91737317
168VDR_23849224_ChIP-Seq_CD4+_Human0.91343262
169* ER_23166858_ChIP-Seq_MCF-7_Human0.91262697
170SMAD3_21741376_ChIP-Seq_ESCs_Human0.90354867
171TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89704187
172TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.89337247
173YY1_21170310_ChIP-Seq_MESCs_Mouse0.88540101
174ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88384643
175SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.87490348
176HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84853490
177TCF3_18692474_ChIP-Seq_MEFs_Mouse0.83935473
178NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.80723609
179EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.80403074
180POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.79788269

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004270_analgesia3.34203623
2MP0003329_amyloid_beta_deposits2.97336030
3MP0000778_abnormal_nervous_system2.82493679
4MP0003693_abnormal_embryo_hatching2.82458872
5MP0004957_abnormal_blastocyst_morpholog2.68119818
6MP0002139_abnormal_hepatobiliary_system2.63400352
7MP0000920_abnormal_myelination2.58425503
8MP0003941_abnormal_skin_development2.56238913
9MP0010094_abnormal_chromosome_stability2.49243391
10MP0003111_abnormal_nucleus_morphology2.42617064
11MP0000566_synostosis2.41572861
12MP0008932_abnormal_embryonic_tissue2.39057023
13MP0004885_abnormal_endolymph2.29157486
14MP0001299_abnormal_eye_distance/2.26381065
15MP0004858_abnormal_nervous_system2.13817559
16MP0000462_abnormal_digestive_system2.09789179
17MP0000537_abnormal_urethra_morphology2.08768142
18MP0003634_abnormal_glial_cell1.92334200
19MP0009780_abnormal_chondrocyte_physiolo1.90264507
20MP0003077_abnormal_cell_cycle1.89674821
21MP0001529_abnormal_vocalization1.84047987
22MP0008058_abnormal_DNA_repair1.83482382
23MP0002734_abnormal_mechanical_nocicepti1.82301359
24MP0004134_abnormal_chest_morphology1.81851924
25MP0003315_abnormal_perineum_morphology1.78042858
26MP0003632_abnormal_nervous_system1.65551273
27MP0001730_embryonic_growth_arrest1.64326838
28MP0005083_abnormal_biliary_tract1.62780517
29MP0000647_abnormal_sebaceous_gland1.60465538
30MP0000955_abnormal_spinal_cord1.59616568
31MP0002733_abnormal_thermal_nociception1.58345138
32MP0006292_abnormal_olfactory_placode1.56964299
33MP0003937_abnormal_limbs/digits/tail_de1.56343119
34MP0003121_genomic_imprinting1.55655423
35MP0008438_abnormal_cutaneous_collagen1.52835813
36MP0001348_abnormal_lacrimal_gland1.51202209
37MP0002084_abnormal_developmental_patter1.51105057
38MP0005423_abnormal_somatic_nervous1.50222033
39MP0003806_abnormal_nucleotide_metabolis1.49798619
40MP0003123_paternal_imprinting1.48513536
41MP0001672_abnormal_embryogenesis/_devel1.48471664
42MP0005380_embryogenesis_phenotype1.48471664
43MP0010678_abnormal_skin_adnexa1.46198620
44MP0005394_taste/olfaction_phenotype1.46031378
45MP0005499_abnormal_olfactory_system1.46031378
46MP0000579_abnormal_nail_morphology1.45494153
47MP0009697_abnormal_copulation1.44234593
48MP0008789_abnormal_olfactory_epithelium1.43775399
49MP0000604_amyloidosis1.42823429
50MP0002085_abnormal_embryonic_tissue1.42798606
51MP0010234_abnormal_vibrissa_follicle1.42609615
52MP0008007_abnormal_cellular_replicative1.40033764
53MP0003718_maternal_effect1.38115873
54MP0004742_abnormal_vestibular_system1.35842046
55MP0001697_abnormal_embryo_size1.33693158
56MP0003984_embryonic_growth_retardation1.32033671
57MP0004197_abnormal_fetal_growth/weight/1.31463661
58MP0009840_abnormal_foam_cell1.30391365
59MP0003567_abnormal_fetal_cardiomyocyte1.30282929
60MP0002735_abnormal_chemical_nociception1.29787755
61MP0002088_abnormal_embryonic_growth/wei1.29122453
62MP0005623_abnormal_meninges_morphology1.28849706
63MP0001286_abnormal_eye_development1.27908817
64MP0003755_abnormal_palate_morphology1.27579912
65MP0004272_abnormal_basement_membrane1.27086481
66MP0010030_abnormal_orbit_morphology1.26868620
67MP0002184_abnormal_innervation1.26269645
68MP0003283_abnormal_digestive_organ1.25233510
69MP0009250_abnormal_appendicular_skeleto1.25002985
70MP0003690_abnormal_glial_cell1.24118171
71MP0009703_decreased_birth_body1.23585342
72MP0006276_abnormal_autonomic_nervous1.21483346
73MP0000350_abnormal_cell_proliferation1.21233435
74MP0003861_abnormal_nervous_system1.20876504
75MP0002080_prenatal_lethality1.19661460
76MP0002233_abnormal_nose_morphology1.19235207
77MP0000372_irregular_coat_pigmentation1.19127874
78MP0001177_atelectasis1.18692934
79MP0003942_abnormal_urinary_system1.18142430
80MP0002882_abnormal_neuron_morphology1.16755206
81MP0003136_yellow_coat_color1.16064168
82MP0002111_abnormal_tail_morphology1.15561963
83MP0001485_abnormal_pinna_reflex1.14857930
84MP0002938_white_spotting1.14398215
85MP0002896_abnormal_bone_mineralization1.14102643
86MP0005187_abnormal_penis_morphology1.13845316
87MP0008057_abnormal_DNA_replication1.13651971
88MP0005248_abnormal_Harderian_gland1.12918691
89MP0002234_abnormal_pharynx_morphology1.11584721
90MP0004142_abnormal_muscle_tone1.10569333
91MP0003195_calcinosis1.09842947
92MP0002152_abnormal_brain_morphology1.08143117
93MP0002089_abnormal_postnatal_growth/wei1.07252588
94MP0005171_absent_coat_pigmentation1.07180829
95MP0003705_abnormal_hypodermis_morpholog1.06992379
96MP0001293_anophthalmia1.06326223
97MP0003115_abnormal_respiratory_system1.06035866
98MP0003935_abnormal_craniofacial_develop1.05879407
99MP0008995_early_reproductive_senescence1.05616701
100MP0002653_abnormal_ependyma_morphology1.05383941
101MP0009672_abnormal_birth_weight1.05127656
102MP0002098_abnormal_vibrissa_morphology1.04850977
103MP0003890_abnormal_embryonic-extraembry1.04359844
104MP0009384_cardiac_valve_regurgitation1.04006089
105MP0002282_abnormal_trachea_morphology1.03921856
106MP0001340_abnormal_eyelid_morphology1.03202278
107MP0004859_abnormal_synaptic_plasticity1.02055790
108MP0000534_abnormal_ureter_morphology1.01698055
109MP0000762_abnormal_tongue_morphology1.01587632
110MP0002086_abnormal_extraembryonic_tissu1.01194198
111MP0000383_abnormal_hair_follicle1.01095486
112MP0005501_abnormal_skin_physiology1.00294421
113MP0003635_abnormal_synaptic_transmissio1.00041698
114MP0005076_abnormal_cell_differentiation0.98572544
115MP0003950_abnormal_plasma_membrane0.97362698
116MP0001970_abnormal_pain_threshold0.96753830
117MP0003786_premature_aging0.95025503
118MP0000428_abnormal_craniofacial_morphol0.94587198
119MP0001486_abnormal_startle_reflex0.94242682
120MP0009053_abnormal_anal_canal0.93133209
121MP0002092_abnormal_eye_morphology0.92873902
122MP0003011_delayed_dark_adaptation0.92693662
123MP0004264_abnormal_extraembryonic_tissu0.91307084
124MP0000427_abnormal_hair_cycle0.90874288
125MP0001905_abnormal_dopamine_level0.90665577
126MP0002063_abnormal_learning/memory/cond0.90648099
127MP0004133_heterotaxia0.90642852
128MP0002210_abnormal_sex_determination0.90136727
129MP0000467_abnormal_esophagus_morphology0.89973382
130MP0004811_abnormal_neuron_physiology0.89654994
131MP0001849_ear_inflammation0.89269477
132MP0005257_abnormal_intraocular_pressure0.88456458
133MP0002249_abnormal_larynx_morphology0.87753614
134MP0001188_hyperpigmentation0.87538676
135MP0004233_abnormal_muscle_weight0.87523409
136MP0002116_abnormal_craniofacial_bone0.87401928
137MP0003385_abnormal_body_wall0.87136553
138MP0003122_maternal_imprinting0.86906891
139MP0003631_nervous_system_phenotype0.86667971
140MP0000631_abnormal_neuroendocrine_gland0.86493160
141MP0003880_abnormal_central_pattern0.85679199
142MP0002752_abnormal_somatic_nervous0.84976991
143MP0002751_abnormal_autonomic_nervous0.84272242
144MP0002160_abnormal_reproductive_system0.83639351
145MP0000049_abnormal_middle_ear0.83355108
146MP0005360_urolithiasis0.82589763
147MP0002066_abnormal_motor_capabilities/c0.82350596
148MP0004924_abnormal_behavior0.81992667
149MP0005386_behavior/neurological_phenoty0.81992667
150MP0002081_perinatal_lethality0.81849010
151MP0005408_hypopigmentation0.81166780
152MP0001915_intracranial_hemorrhage0.80686377
153MP0002796_impaired_skin_barrier0.80593404
154MP0002229_neurodegeneration0.80566785
155MP0001440_abnormal_grooming_behavior0.80420499
156MP0002697_abnormal_eye_size0.80404058
157MP0002295_abnormal_pulmonary_circulatio0.80082244
158MP0003119_abnormal_digestive_system0.79965839
159MP0005391_vision/eye_phenotype0.79456437
160MP0001145_abnormal_male_reproductive0.77023868
161MP0008877_abnormal_DNA_methylation0.75850061
162MP0001929_abnormal_gametogenesis0.75216355

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.27155962
2Cerebral inclusion bodies (HP:0100314)4.72619659
3Abnormality of the corticospinal tract (HP:0002492)4.39376641
4Insidious onset (HP:0003587)4.35895265
5Termporal pattern (HP:0011008)4.35895265
6Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.29931054
7Degeneration of the lateral corticospinal tracts (HP:0002314)4.29931054
8Parakeratosis (HP:0001036)3.83596244
9Hypoplastic pelvis (HP:0008839)3.63162927
10Megalencephaly (HP:0001355)3.21481202
11Supranuclear gaze palsy (HP:0000605)3.13197894
12Increased nuchal translucency (HP:0010880)3.11679031
13Abnormality of glycolysis (HP:0004366)3.10534913
14Increased serum pyruvate (HP:0003542)3.10534913
15Abnormal lung lobation (HP:0002101)2.94862673
16Spastic gait (HP:0002064)2.86975034
17Akinesia (HP:0002304)2.84942011
18Chromosomal breakage induced by crosslinking agents (HP:0003221)2.82372509
19Chromsome breakage (HP:0040012)2.78923915
20Overlapping toe (HP:0001845)2.75075420
21Ankle clonus (HP:0011448)2.72368069
22Coronal craniosynostosis (HP:0004440)2.68882929
23Morphological abnormality of the pyramidal tract (HP:0002062)2.66874300
24Abnormality of the labia minora (HP:0012880)2.62129414
25Nephroblastoma (Wilms tumor) (HP:0002667)2.59049581
26Pheochromocytoma (HP:0002666)2.58546545
27Peripheral hypomyelination (HP:0007182)2.58209609
28Myelomeningocele (HP:0002475)2.55825037
29Proximal placement of thumb (HP:0009623)2.44238931
30Embryonal renal neoplasm (HP:0011794)2.42784069
31Epiphyseal dysplasia (HP:0002656)2.41432745
32Deviation of the thumb (HP:0009603)2.40328865
33Relative macrocephaly (HP:0004482)2.38108528
34Microglossia (HP:0000171)2.37588187
35Segmental peripheral demyelination/remyelination (HP:0003481)2.35150140
36Hammertoe (HP:0001765)2.29348617
37Aplasia/Hypoplasia of the sternum (HP:0006714)2.23215402
38Anteriorly placed anus (HP:0001545)2.17708323
39Back pain (HP:0003418)2.17207483
40Neuroendocrine neoplasm (HP:0100634)2.13489832
41Premature rupture of membranes (HP:0001788)2.12985455
42Onion bulb formation (HP:0003383)2.12589642
43Medulloblastoma (HP:0002885)2.11378206
44Generalized hypotonia (HP:0001290)2.10877257
45Facial hemangioma (HP:0000329)2.09254565
46Urinary urgency (HP:0000012)2.08711832
47Autoamputation (HP:0001218)2.08244604
48Spastic paraplegia (HP:0001258)2.07532106
49Meckel diverticulum (HP:0002245)2.06676855
50Hyperglycinemia (HP:0002154)2.06428964
51Buphthalmos (HP:0000557)2.06206329
52High anterior hairline (HP:0009890)2.05370958
53Clonus (HP:0002169)2.04366136
54Turricephaly (HP:0000262)2.04302659
55Irregular epiphyses (HP:0010582)2.03297718
56Vertebral clefting (HP:0008428)2.01312332
57Aplasia involving bones of the upper limbs (HP:0009823)2.01294181
58Aplasia of the phalanges of the hand (HP:0009802)2.01294181
59Aplasia involving bones of the extremities (HP:0009825)2.01294181
60Intrahepatic cholestasis (HP:0001406)2.01210369
61Abnormality of nail color (HP:0100643)1.98829583
62Epidermoid cyst (HP:0200040)1.98720648
63Lower limb muscle weakness (HP:0007340)1.98078121
64Septate vagina (HP:0001153)1.98007903
65Abnormal gallbladder physiology (HP:0012438)1.96547454
66Cholecystitis (HP:0001082)1.96547454
67Congenital ichthyosiform erythroderma (HP:0007431)1.94465056
68Capillary hemangiomas (HP:0005306)1.94078720
69Missing ribs (HP:0000921)1.93373329
70Partial agenesis of the corpus callosum (HP:0001338)1.93134401
71Abnormality of the ileum (HP:0001549)1.93134104
72Amyotrophic lateral sclerosis (HP:0007354)1.92371657
73Papillary thyroid carcinoma (HP:0002895)1.92086986
74Broad alveolar ridges (HP:0000187)1.90906797
75Xanthomatosis (HP:0000991)1.90193635
76Fragile nails (HP:0001808)1.88848242
77Alacrima (HP:0000522)1.87806614
78Scrotal hypoplasia (HP:0000046)1.87385041
79Retinal dysplasia (HP:0007973)1.86614688
80Paraplegia (HP:0010550)1.86113165
81Bifid tongue (HP:0010297)1.79393001
82Bicornuate uterus (HP:0000813)1.77885704
83Hepatoblastoma (HP:0002884)1.77717390
84Protuberant abdomen (HP:0001538)1.77565903
85Sensory axonal neuropathy (HP:0003390)1.77325391
86Hypsarrhythmia (HP:0002521)1.77227320
87Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.77215876
88Vertebral hypoplasia (HP:0008417)1.77215876
89Hemivertebrae (HP:0002937)1.75834269
90Infantile muscular hypotonia (HP:0008947)1.75214037
91Shoulder girdle muscle weakness (HP:0003547)1.74434588
92Adrenal hypoplasia (HP:0000835)1.74275899
93Embryonal neoplasm (HP:0002898)1.73497761
94Distal sensory impairment (HP:0002936)1.73375646
95Multiple enchondromatosis (HP:0005701)1.72640551
96Aplasia/Hypoplasia of the uvula (HP:0010293)1.72254091
97Clumsiness (HP:0002312)1.71728182
98Intention tremor (HP:0002080)1.71084851
99Abnormality of aromatic amino acid family metabolism (HP:0004338)1.70552070
100Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.70422384
101Humeroradial synostosis (HP:0003041)1.70263785
102Synostosis involving the elbow (HP:0003938)1.70263785
103Deep venous thrombosis (HP:0002625)1.70229048
104Stridor (HP:0010307)1.70077592
105Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.69668307
106Duodenal stenosis (HP:0100867)1.69450297
107Small intestinal stenosis (HP:0012848)1.69450297
108EEG with generalized epileptiform discharges (HP:0011198)1.69426578
109Abnormality of the preputium (HP:0100587)1.68890626
110Abnormality of chromosome stability (HP:0003220)1.68358890
111Horseshoe kidney (HP:0000085)1.67621645
112Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.67544593
113Cerebral hypomyelination (HP:0006808)1.67402547
114Spastic diplegia (HP:0001264)1.67263006
115Small epiphyses (HP:0010585)1.67227525
116Spastic tetraparesis (HP:0001285)1.66239183
117Pterygium (HP:0001059)1.66234893
118Premature skin wrinkling (HP:0100678)1.65594821
119Abnormality of the phalanges of the 2nd finger (HP:0009541)1.65449697
120Absent eyelashes (HP:0000561)1.64618127
121Hypoplasia of the capital femoral epiphysis (HP:0003090)1.64440604
122Delayed epiphyseal ossification (HP:0002663)1.63613037
123Hypoplastic female external genitalia (HP:0012815)1.62888722
124Meningocele (HP:0002435)1.62811559
125Absent radius (HP:0003974)1.62612513
12611 pairs of ribs (HP:0000878)1.62338366
127Bifid scrotum (HP:0000048)1.62247604
128Pachygyria (HP:0001302)1.60328375
129Rhabdomyosarcoma (HP:0002859)1.60068254
130Choanal atresia (HP:0000453)1.59053446
131Lissencephaly (HP:0001339)1.58467316
132Aplasia involving forearm bones (HP:0009822)1.57955152
133Absent forearm bone (HP:0003953)1.57955152
134Abnormality of the duodenum (HP:0002246)1.57516784
135Hypoplasia of the brainstem (HP:0002365)1.57147853
136Aplasia/Hypoplasia of the brainstem (HP:0007362)1.57147853
137Volvulus (HP:0002580)1.56941243
138Aqueductal stenosis (HP:0002410)1.56341090
139Abnormality of the alveolar ridges (HP:0006477)1.55388251
140Labial hypoplasia (HP:0000066)1.54584391
141Abnormality of cochlea (HP:0000375)1.54560220
142Bronchomalacia (HP:0002780)1.54470344
143Epileptiform EEG discharges (HP:0011182)1.52974027
144Vitreoretinal degeneration (HP:0000655)1.52766056
145Thyroid carcinoma (HP:0002890)1.52605324
146Decreased motor nerve conduction velocity (HP:0003431)1.52044164
147Short clavicles (HP:0000894)1.51897048
148Birth length less than 3rd percentile (HP:0003561)1.51706025
149Aplasia/Hypoplasia of the clavicles (HP:0006710)1.51290523
150Esophageal atresia (HP:0002032)1.51209448
151Colon cancer (HP:0003003)1.51006624
152Abnormal auditory evoked potentials (HP:0006958)1.50896892
153Peritonitis (HP:0002586)1.50668674
154Ependymoma (HP:0002888)1.50539417
155Abnormality of the carotid arteries (HP:0005344)1.49629256
156Cortical dysplasia (HP:0002539)1.49586042
157Absent eyebrow (HP:0002223)1.49022807
158Type II lissencephaly (HP:0007260)1.48247136
159Abnormality of the vitreous humor (HP:0004327)1.48119531
160Cutaneous finger syndactyly (HP:0010554)1.47717761
161Curly hair (HP:0002212)1.46778245
162Breech presentation (HP:0001623)1.46711139
163Cutaneous syndactyly (HP:0012725)1.46537593
164Hand muscle atrophy (HP:0009130)1.46439420
165Heterotopia (HP:0002282)1.46241787
166Absent epiphyses (HP:0010577)1.45798858
167Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.45798858
168Postnatal microcephaly (HP:0005484)1.45538099
169Asymmetry of the thorax (HP:0001555)1.44227609
170Renal hypoplasia (HP:0000089)1.44051561
171Facial cleft (HP:0002006)1.43394361
172Midline defect of the nose (HP:0004122)1.42615428
173Onycholysis (HP:0001806)1.42594526
174Anophthalmia (HP:0000528)1.40717945
175Aplasia/hypoplasia of the humerus (HP:0006507)1.38978505
176Leiomyosarcoma (HP:0100243)1.36579089
177Uterine leiomyosarcoma (HP:0002891)1.36579089
178Skull defect (HP:0001362)1.36170096

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.72312995
2STK393.39633416
3SRPK13.14159666
4TTK3.11074578
5NEK12.98593137
6TSSK62.98040385
7EPHB12.82033751
8DYRK22.75330945
9BCR2.67388290
10NTRK12.67003205
11LIMK12.65582213
12MET2.50450201
13WEE12.29117367
14EIF2AK12.27688660
15FGFR22.05363708
16TRIM282.02996322
17PLK41.96574307
18CSNK1G31.92665464
19OXSR11.91207659
20TESK21.88558704
21UHMK11.87448516
22MAP3K91.83937796
23WNK41.77216679
24CSNK1A1L1.76652261
25CSNK1G21.74942930
26DDR21.72145037
27MAP3K21.69648775
28PBK1.68153704
29LATS21.65022877
30PAK31.64194276
31PNCK1.61638997
32ERBB41.59561115
33NTRK21.50554741
34KSR21.46898441
35EIF2AK31.45673778
36PAK61.45603724
37MAP3K101.45102017
38MKNK21.44332093
39CSNK1G11.39289672
40PKN11.38337660
41EEF2K1.35843856
42PLK11.35367417
43BRSK21.30023763
44CASK1.29337070
45TYRO31.25971956
46CDK141.24741697
47LATS11.24278283
48KSR11.23031500
49ICK1.22364958
50SCYL21.19243079
51ERBB31.18717343
52MINK11.17525522
53MAPK131.17243756
54MAPKAPK51.16472350
55TESK11.14145463
56PASK1.13422067
57CAMK1G1.12704877
58CDK71.12555756
59CHEK21.12245367
60ATR1.11030586
61PKN21.10634610
62PHKG21.09005657
63PHKG11.09005657
64NEK21.08866941
65PLK21.08823080
66EPHA31.07890252
67SIK11.06508462
68CDK121.06266116
69RPS6KA41.06073989
70MAP2K71.02820318
71CDK151.01910822
72PTK21.01565895
73CDK180.99201683
74DYRK30.97849081
75RET0.97587905
76FGR0.96699706
77PAK40.96396236
78CHEK10.95022076
79AURKB0.94920961
80BRD40.93764010
81BRSK10.93690345
82RPS6KB20.92922175
83EPHB20.89651954
84CDK11A0.89315965
85ROCK20.88843666
86CAMK1D0.87314628
87TAF10.86219112
88ATM0.85919326
89PDGFRA0.81363624
90CDK50.81142124
91MARK20.79473595
92CCNB10.78858344
93FGFR10.77794741
94BMPR1B0.75388427
95CDK10.74872303
96SMG10.74658945
97BRAF0.72588008
98FER0.72219344
99VRK20.71466497
100VRK10.69945001
101ZAK0.69297432
102WNK10.67811401
103PDGFRB0.65470559
104GSK3A0.64662852
105FGFR40.63969087
106MAP3K40.63898002
107YES10.63023996
108CDK20.62691772
109CSNK1D0.61801483
110DYRK1A0.61003848
111CDK190.60870078
112SGK2230.60705996
113SGK4940.60705996
114RAF10.60265917
115CLK10.60252338
116CAMK2B0.59445515
117ERBB20.58443934
118AURKA0.58281720
119MST1R0.58245266
120PLK30.57739485
121PAK20.56184642
122MAP3K80.54714334
123EIF2AK20.54523433
124NTRK30.54140066
125PRKDC0.51237945
126STK160.49639154
127CDC70.49586916
128STK30.48887263
129PRKCE0.48825307
130BMX0.48702503
131CSNK1E0.48518625
132MKNK10.48090452
133CDK60.47655990
134PRKCI0.46167652
135MTOR0.46006349
136ALK0.45375607
137PRKD30.44898379
138PRKCZ0.44544735
139AKT20.44127611
140STK38L0.43546718
141MAP2K20.42776081
142MAP2K10.42464666
143CDK80.41978185
144WNK30.41893782
145CSNK2A20.41574476
146CDK30.41178204
147CAMK2A0.40780672
148EPHA20.40621877
149ABL20.39934402
150PRKCG0.39868272
151MAPK90.39746249
152PAK10.39500562
153ADRBK10.38357218
154FYN0.37282041
155LMTK20.36994954
156BUB10.35502848
157CAMK2D0.34849176

Predicted pathways (KEGG)

RankGene SetZ-score
1* Steroid biosynthesis_Homo sapiens_hsa001006.86547021
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009006.73575024
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.12879485
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.58928030
5Fatty acid elongation_Homo sapiens_hsa000623.00441750
6Butanoate metabolism_Homo sapiens_hsa006502.62024947
7DNA replication_Homo sapiens_hsa030302.36629847
8Mismatch repair_Homo sapiens_hsa034302.24301490
9Sulfur metabolism_Homo sapiens_hsa009202.05423741
10Spliceosome_Homo sapiens_hsa030402.02664073
11RNA transport_Homo sapiens_hsa030131.97372599
12Cell cycle_Homo sapiens_hsa041101.80845966
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.76075721
14Non-homologous end-joining_Homo sapiens_hsa034501.73333417
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.71907799
16Base excision repair_Homo sapiens_hsa034101.68993444
17Axon guidance_Homo sapiens_hsa043601.67898518
18Ether lipid metabolism_Homo sapiens_hsa005651.66988692
19One carbon pool by folate_Homo sapiens_hsa006701.59991681
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.59187201
21Fatty acid metabolism_Homo sapiens_hsa012121.57166623
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.54943799
23mRNA surveillance pathway_Homo sapiens_hsa030151.54530313
24Nucleotide excision repair_Homo sapiens_hsa034201.46192135
25Fatty acid biosynthesis_Homo sapiens_hsa000611.44330405
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.42059216
27Nitrogen metabolism_Homo sapiens_hsa009101.39656401
28Fanconi anemia pathway_Homo sapiens_hsa034601.36318900
29Carbon metabolism_Homo sapiens_hsa012001.35105604
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.30442963
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.30278643
32Homologous recombination_Homo sapiens_hsa034401.23665518
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22912582
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.11910190
35Basal transcription factors_Homo sapiens_hsa030221.11435732
36Vitamin B6 metabolism_Homo sapiens_hsa007501.11378212
37Proteasome_Homo sapiens_hsa030501.10376336
38Hedgehog signaling pathway_Homo sapiens_hsa043401.09396802
39Sphingolipid metabolism_Homo sapiens_hsa006001.07256120
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07142590
41Renal cell carcinoma_Homo sapiens_hsa052111.04937399
42Histidine metabolism_Homo sapiens_hsa003401.01549932
43RNA degradation_Homo sapiens_hsa030181.00476750
44RNA polymerase_Homo sapiens_hsa030200.98336544
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.94796761
46Protein export_Homo sapiens_hsa030600.94218942
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93815643
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91744491
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89859065
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89189862
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88826378
52Thyroid cancer_Homo sapiens_hsa052160.86722545
53Vibrio cholerae infection_Homo sapiens_hsa051100.86554914
54Hippo signaling pathway_Homo sapiens_hsa043900.84788888
55Adherens junction_Homo sapiens_hsa045200.83216538
56Lysine degradation_Homo sapiens_hsa003100.82716681
57Tight junction_Homo sapiens_hsa045300.82264774
58Basal cell carcinoma_Homo sapiens_hsa052170.81690178
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80492963
60Pyruvate metabolism_Homo sapiens_hsa006200.79761764
61Dorso-ventral axis formation_Homo sapiens_hsa043200.79731840
62Pyrimidine metabolism_Homo sapiens_hsa002400.79336248
63Bile secretion_Homo sapiens_hsa049760.76369102
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.74351650
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74167535
66Linoleic acid metabolism_Homo sapiens_hsa005910.71100788
67Tryptophan metabolism_Homo sapiens_hsa003800.70794944
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70064439
69Cocaine addiction_Homo sapiens_hsa050300.68809540
70Tyrosine metabolism_Homo sapiens_hsa003500.68080209
71Fat digestion and absorption_Homo sapiens_hsa049750.66674538
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.65991266
73Arginine and proline metabolism_Homo sapiens_hsa003300.65520771
74Serotonergic synapse_Homo sapiens_hsa047260.65434424
75Long-term depression_Homo sapiens_hsa047300.61722844
76Pentose phosphate pathway_Homo sapiens_hsa000300.61698846
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61685198
78p53 signaling pathway_Homo sapiens_hsa041150.61617414
79Gap junction_Homo sapiens_hsa045400.61386161
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.61160563
81Peroxisome_Homo sapiens_hsa041460.61079845
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60571771
83ErbB signaling pathway_Homo sapiens_hsa040120.60201364
84Prion diseases_Homo sapiens_hsa050200.57048137
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56673146
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55735707
87Dopaminergic synapse_Homo sapiens_hsa047280.55368967
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54776702
89TGF-beta signaling pathway_Homo sapiens_hsa043500.54766614
90Glioma_Homo sapiens_hsa052140.53936851
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52982660
92Arginine biosynthesis_Homo sapiens_hsa002200.52870203
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52157368
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51364952
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50563188
96Ovarian steroidogenesis_Homo sapiens_hsa049130.50491674
97* Metabolic pathways_Homo sapiens_hsa011000.49011736
98Alcoholism_Homo sapiens_hsa050340.48604649
99Propanoate metabolism_Homo sapiens_hsa006400.48106694
100Bladder cancer_Homo sapiens_hsa052190.48071883
101Synaptic vesicle cycle_Homo sapiens_hsa047210.47716414
102Folate biosynthesis_Homo sapiens_hsa007900.47659122
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46911355
104Fatty acid degradation_Homo sapiens_hsa000710.46852100
105Selenocompound metabolism_Homo sapiens_hsa004500.45776215
106Melanogenesis_Homo sapiens_hsa049160.45002683
107Phenylalanine metabolism_Homo sapiens_hsa003600.44987539
108Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44192286
109ECM-receptor interaction_Homo sapiens_hsa045120.42014488
110Estrogen signaling pathway_Homo sapiens_hsa049150.41645453
111GABAergic synapse_Homo sapiens_hsa047270.41519399
112Endocytosis_Homo sapiens_hsa041440.40825865
113Cholinergic synapse_Homo sapiens_hsa047250.40627573
114Purine metabolism_Homo sapiens_hsa002300.40405053
115Endometrial cancer_Homo sapiens_hsa052130.39497457
116Glutathione metabolism_Homo sapiens_hsa004800.37677939
117Fructose and mannose metabolism_Homo sapiens_hsa000510.35922738
118Insulin secretion_Homo sapiens_hsa049110.35301923
119Glutamatergic synapse_Homo sapiens_hsa047240.35219089
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35132621
121N-Glycan biosynthesis_Homo sapiens_hsa005100.34777081
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.33789300
123Vitamin digestion and absorption_Homo sapiens_hsa049770.33206709
124Phagosome_Homo sapiens_hsa041450.32246404
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32141851
126Ras signaling pathway_Homo sapiens_hsa040140.32115769
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.32002804
128Biosynthesis of amino acids_Homo sapiens_hsa012300.31537345
129Mineral absorption_Homo sapiens_hsa049780.31352683
130Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.31089911
131AMPK signaling pathway_Homo sapiens_hsa041520.30900375
132Retinol metabolism_Homo sapiens_hsa008300.30752291
133MicroRNAs in cancer_Homo sapiens_hsa052060.30586135
134Huntingtons disease_Homo sapiens_hsa050160.29934497
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29074110
136Wnt signaling pathway_Homo sapiens_hsa043100.28221372
137Prostate cancer_Homo sapiens_hsa052150.28185426
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27951690
139Chemical carcinogenesis_Homo sapiens_hsa052040.27927691
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26994360
141PPAR signaling pathway_Homo sapiens_hsa033200.26956718
142Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26681600
143Ribosome_Homo sapiens_hsa030100.26029684
144Colorectal cancer_Homo sapiens_hsa052100.25942671
145Oocyte meiosis_Homo sapiens_hsa041140.25522459
146Phospholipase D signaling pathway_Homo sapiens_hsa040720.25051984
147Melanoma_Homo sapiens_hsa052180.22844865
148Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.22239716

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