SQRDL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.54769417
2L-phenylalanine catabolic process (GO:0006559)6.54769417
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.29374315
4L-phenylalanine metabolic process (GO:0006558)6.29374315
5aromatic amino acid family catabolic process (GO:0009074)5.95285677
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.64494255
7indole-containing compound catabolic process (GO:0042436)5.42025762
8indolalkylamine catabolic process (GO:0046218)5.42025762
9tryptophan catabolic process (GO:0006569)5.42025762
10kynurenine metabolic process (GO:0070189)5.24574909
11alpha-linolenic acid metabolic process (GO:0036109)5.17124106
12tryptophan metabolic process (GO:0006568)5.12385255
13urea metabolic process (GO:0019627)5.11513858
14urea cycle (GO:0000050)5.11513858
15bile acid biosynthetic process (GO:0006699)5.06722224
16* sulfur amino acid catabolic process (GO:0000098)5.00187985
17glyoxylate metabolic process (GO:0046487)4.98075480
18cysteine metabolic process (GO:0006534)4.94305329
19peptidyl-glutamic acid carboxylation (GO:0017187)4.93234858
20protein carboxylation (GO:0018214)4.93234858
21complement activation, alternative pathway (GO:0006957)4.92728091
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.85229429
23high-density lipoprotein particle remodeling (GO:0034375)4.82286673
24nitrogen cycle metabolic process (GO:0071941)4.72237740
25regulation of protein activation cascade (GO:2000257)4.67752396
26negative regulation of fibrinolysis (GO:0051918)4.67636343
27bile acid metabolic process (GO:0008206)4.57044573
28homocysteine metabolic process (GO:0050667)4.56601161
29negative regulation of interleukin-12 production (GO:0032695)4.55988276
30regulation of triglyceride catabolic process (GO:0010896)4.51646621
31regulation of fibrinolysis (GO:0051917)4.43720537
32regulation of complement activation (GO:0030449)4.41618559
33bile acid and bile salt transport (GO:0015721)4.41040700
34lysine metabolic process (GO:0006553)4.39012811
35lysine catabolic process (GO:0006554)4.39012811
36response to peptidoglycan (GO:0032494)4.36116748
37serine family amino acid catabolic process (GO:0009071)4.32906731
38amino-acid betaine metabolic process (GO:0006577)4.32163180
39reverse cholesterol transport (GO:0043691)4.29895050
40aromatic amino acid family metabolic process (GO:0009072)4.28798919
41regulation of cholesterol esterification (GO:0010872)4.27613448
42cellular ketone body metabolic process (GO:0046950)4.27564784
43protein-lipid complex remodeling (GO:0034368)4.26848925
44macromolecular complex remodeling (GO:0034367)4.26848925
45plasma lipoprotein particle remodeling (GO:0034369)4.26848925
46plasma lipoprotein particle clearance (GO:0034381)4.23552103
47phospholipid efflux (GO:0033700)4.20213477
48triglyceride homeostasis (GO:0070328)4.16288859
49acylglycerol homeostasis (GO:0055090)4.16288859
50cellular glucuronidation (GO:0052695)4.11682965
51tyrosine metabolic process (GO:0006570)4.11658877
52regulation of vitamin D biosynthetic process (GO:0060556)4.08716973
53negative regulation of cholesterol transport (GO:0032375)4.04992934
54negative regulation of sterol transport (GO:0032372)4.04992934
55ethanol oxidation (GO:0006069)4.04274159
56alpha-amino acid catabolic process (GO:1901606)4.03428863
57immunoglobulin mediated immune response (GO:0016064)3.95389098
58neutrophil activation involved in immune response (GO:0002283)3.90410882
59positive regulation of gamma-delta T cell activation (GO:0046645)3.83941818
60indolalkylamine metabolic process (GO:0006586)3.83801732
61lipopolysaccharide-mediated signaling pathway (GO:0031663)3.77133524
62coenzyme catabolic process (GO:0009109)3.75498852
63* cellular amino acid catabolic process (GO:0009063)3.74924446
64benzene-containing compound metabolic process (GO:0042537)3.74835686
65macrophage activation involved in immune response (GO:0002281)3.74390731
66cholesterol efflux (GO:0033344)3.74187677
67drug catabolic process (GO:0042737)3.73961727
68amine catabolic process (GO:0009310)3.73602940
69cellular biogenic amine catabolic process (GO:0042402)3.73602940
70uronic acid metabolic process (GO:0006063)3.72623639
71glucuronate metabolic process (GO:0019585)3.72623639
72cellular response to type I interferon (GO:0071357)3.71934058
73type I interferon signaling pathway (GO:0060337)3.71934058
74flavonoid metabolic process (GO:0009812)3.69130507
75phospholipid homeostasis (GO:0055091)3.68974911
76short-chain fatty acid metabolic process (GO:0046459)3.68909012
77low-density lipoprotein particle remodeling (GO:0034374)3.68819614
78ketone body metabolic process (GO:1902224)3.67343968
79response to type I interferon (GO:0034340)3.66279884
80regulation of vitamin metabolic process (GO:0030656)3.65755526
81aldehyde catabolic process (GO:0046185)3.65407629
82plasma lipoprotein particle assembly (GO:0034377)3.64804802
83NIK/NF-kappaB signaling (GO:0038061)3.63696266
84positive regulation of lipid catabolic process (GO:0050996)3.61481851
85fatty acid beta-oxidation (GO:0006635)3.58990556
86fatty acid oxidation (GO:0019395)3.58050365
87imidazole-containing compound metabolic process (GO:0052803)3.57952329
88fibrinolysis (GO:0042730)3.54044620
89cellular modified amino acid catabolic process (GO:0042219)3.52977361
90lipid oxidation (GO:0034440)3.52720489
91regulation of mononuclear cell migration (GO:0071675)3.51560261
92positive regulation of lipoprotein lipase activity (GO:0051006)3.51416029
93positive regulation of triglyceride lipase activity (GO:0061365)3.51416029
94interferon-gamma-mediated signaling pathway (GO:0060333)3.50779979
95cholesterol homeostasis (GO:0042632)3.49836249
96glutamate metabolic process (GO:0006536)3.49517515
97regulation of cholesterol homeostasis (GO:2000188)3.47661827
98positive regulation by symbiont of host defense response (GO:0052509)3.47071494
99modulation by symbiont of host defense response (GO:0052031)3.47071494
100modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.47071494
101modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.47071494
102positive regulation by organism of defense response of other organism involved in symbiotic interact3.47071494
103modulation by symbiont of host immune response (GO:0052553)3.47071494
104negative regulation of cell killing (GO:0031342)3.46620931
105negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.46620931
106drug transmembrane transport (GO:0006855)3.46392897
107cofactor catabolic process (GO:0051187)3.46189716
108* carboxylic acid catabolic process (GO:0046395)3.45810114
109* organic acid catabolic process (GO:0016054)3.45810114
110sterol homeostasis (GO:0055092)3.45337098
111serine family amino acid metabolic process (GO:0009069)3.44462318
112monocarboxylic acid catabolic process (GO:0072329)3.43894813
113glycine metabolic process (GO:0006544)3.43070458
114fatty acid catabolic process (GO:0009062)3.42600747
115very-low-density lipoprotein particle assembly (GO:0034379)3.42386794
116arginine metabolic process (GO:0006525)3.41274360
117regulation of T-helper 1 cell differentiation (GO:0045625)3.40398541
118carnitine metabolic process (GO:0009437)3.40139813
119acetyl-CoA metabolic process (GO:0006084)3.38915613
120regulation of bile acid biosynthetic process (GO:0070857)3.37697468
121antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.36854552
122plasma lipoprotein particle organization (GO:0071827)3.36668629
123regulation of podosome assembly (GO:0071801)3.35835840
124complement activation (GO:0006956)3.34224872
125negative regulation of lipase activity (GO:0060192)3.33554321
126antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.32858224
127protein activation cascade (GO:0072376)3.31856767
128T-helper 1 type immune response (GO:0042088)3.27892986
129detection of other organism (GO:0098543)3.27690335
130myeloid dendritic cell differentiation (GO:0043011)3.26372218
131antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.23505831
132antigen processing and presentation of endogenous antigen (GO:0019883)3.23152672
133regulation of dendritic cell antigen processing and presentation (GO:0002604)3.22043889
134glycosphingolipid catabolic process (GO:0046479)3.20038497
135positive regulation of chemokine biosynthetic process (GO:0045080)3.18015988
136detection of bacterium (GO:0016045)3.10868641
137regulation of cytokine secretion involved in immune response (GO:0002739)3.10661693
138regulation of interferon-alpha production (GO:0032647)3.09641230
139granulocyte activation (GO:0036230)3.07212330
140regulation of interferon-beta biosynthetic process (GO:0045357)3.06898108
141positive regulation of type 2 immune response (GO:0002830)3.05791106
142germinal center formation (GO:0002467)3.01426009
143positive regulation of antigen processing and presentation (GO:0002579)3.00487069
144regulation of antigen processing and presentation (GO:0002577)2.98055296
145defense response to protozoan (GO:0042832)2.97344374
146regulation of T cell tolerance induction (GO:0002664)2.97151182
147negative regulation of cytokine production involved in immune response (GO:0002719)2.96643333
148B cell mediated immunity (GO:0019724)2.96482722
149response to protozoan (GO:0001562)2.96284032
150regulation of chronic inflammatory response (GO:0002676)2.96086155
151detection of molecule of bacterial origin (GO:0032490)2.94950170
152positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.94945022
153positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.93841469
154glycolipid catabolic process (GO:0019377)2.92928978
155myeloid dendritic cell activation (GO:0001773)2.92807970
156regulation of chemokine biosynthetic process (GO:0045073)2.91910800
157oligosaccharide catabolic process (GO:0009313)2.91813829
158positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.89057537
159detection of external biotic stimulus (GO:0098581)2.89057271
160eosinophil chemotaxis (GO:0048245)2.89029968
161positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.87758507
162cellular response to interferon-gamma (GO:0071346)2.86823612
163negative regulation of nitric oxide biosynthetic process (GO:0045019)2.85516327
164monocyte chemotaxis (GO:0002548)2.84263321
165positive regulation of interferon-alpha production (GO:0032727)2.79411212
166regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.78375648
167negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.77710581
168negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.77300847
169response to interferon-gamma (GO:0034341)2.76403628
170positive regulation of NF-kappaB import into nucleus (GO:0042346)2.75573614
171positive regulation of monocyte chemotaxis (GO:0090026)2.73221403
172regulation of gamma-delta T cell activation (GO:0046643)2.72866476
173lymphocyte chemotaxis (GO:0048247)2.71925934
174myeloid cell activation involved in immune response (GO:0002275)2.71107211
175cellular response to thyroid hormone stimulus (GO:0097067)2.71080643
176dendritic cell differentiation (GO:0097028)2.70601388
177neutrophil activation (GO:0042119)2.70343810
178regulation of membrane protein ectodomain proteolysis (GO:0051043)2.69792251
179regulation of interleukin-12 production (GO:0032655)2.68778041
180regulation of tolerance induction (GO:0002643)2.68678261
181cellular extravasation (GO:0045123)2.68412691
182regulation of type 2 immune response (GO:0002828)2.67490480
183regulation of macrophage chemotaxis (GO:0010758)2.63750593
184regulation of T-helper 2 cell differentiation (GO:0045628)2.63240434
185response to muramyl dipeptide (GO:0032495)2.62330549
186negative regulation of myeloid cell apoptotic process (GO:0033033)2.60621582
187macrophage activation (GO:0042116)2.58686748
188cellular response to lipopolysaccharide (GO:0071222)2.58481410
189leukocyte aggregation (GO:0070486)2.57963997
190eosinophil migration (GO:0072677)2.57213733
191respiratory burst (GO:0045730)2.55216148
192T cell migration (GO:0072678)2.55053742
193cellular response to molecule of bacterial origin (GO:0071219)2.53690357
194ceramide catabolic process (GO:0046514)2.53599640
195positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.53576835
196positive regulation of toll-like receptor signaling pathway (GO:0034123)2.52876407
197detection of biotic stimulus (GO:0009595)2.52492354
198positive regulation of heat generation (GO:0031652)2.52104764
199positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.50913983
200regulation of inflammatory response to antigenic stimulus (GO:0002861)2.48934168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.24812181
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.32804429
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.02020837
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.80798301
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.06605978
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.65806904
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.35368434
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.33643954
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.31107676
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.82908356
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.79790522
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.74737287
13* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.70455867
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.56916281
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.50887290
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.43937100
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.35079347
18VDR_24763502_ChIP-Seq_THP-1_Human2.03584155
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.02698287
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.00994649
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.0695145
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.96687471
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95534976
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.95313873
25SPI1_23547873_ChIP-Seq_NB4_Human1.91236202
26SPI1_23127762_ChIP-Seq_K562_Human1.87749861
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.84163266
28VDR_21846776_ChIP-Seq_THP-1_Human1.81255261
29VDR_24787735_ChIP-Seq_THP-1_Human1.79575560
30TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.77565542
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.68930660
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.66877490
33RUNX_20019798_ChIP-Seq_JUKART_Human1.64916377
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.60357899
35* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.59994543
36CLOCK_20551151_ChIP-Seq_293T_Human1.59592738
37MAF_26560356_Chip-Seq_TH1_Human1.58547920
38* MYB_26560356_Chip-Seq_TH2_Human1.53239020
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50676450
40* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.48301719
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.46972164
42* FOXA2_19822575_ChIP-Seq_HepG2_Human1.42605074
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40763338
44LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39277985
45GATA1_22025678_ChIP-Seq_K562_Human1.37630222
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.35937866
47SCL_19346495_ChIP-Seq_HPC-7_Human1.35248570
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.35108522
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32560253
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32295198
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.27800584
52HNF4A_19822575_ChIP-Seq_HepG2_Human1.27784737
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24858871
54PU_27001747_Chip-Seq_BMDM_Mouse1.24681264
55HTT_18923047_ChIP-ChIP_STHdh_Human1.24543176
56PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23778607
57NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23107518
58UTX_26944678_Chip-Seq_JUKART_Human1.22551398
59* MYB_26560356_Chip-Seq_TH1_Human1.22471253
60* GATA4_25053715_ChIP-Seq_YYC3_Human1.20962653
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20554867
62SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19238702
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.17020056
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16765366
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15267089
66TCF7_22412390_ChIP-Seq_EML_Mouse1.12973145
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12093176
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11666398
69RXRA_24833708_ChIP-Seq_LIVER_Mouse1.11259318
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10886639
71GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10614432
72* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08589652
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04950683
74ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04306846
75* MAF_26560356_Chip-Seq_TH2_Human1.03637386
76GATA3_27048872_Chip-Seq_THYMUS_Human1.03119396
77IRF8_27001747_Chip-Seq_BMDM_Mouse1.02863759
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99407827
79IRF8_21731497_ChIP-ChIP_J774_Mouse0.99237978
80KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98703213
81GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98330903
82P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97483441
83* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97294612
84STAT1_20625510_ChIP-Seq_HELA_Human0.96919220
85CDX2_20551321_ChIP-Seq_CACO-2_Human0.95089697
86GATA3_26560356_Chip-Seq_TH2_Human0.94959951
87KDM2B_26808549_Chip-Seq_DND41_Human0.94368403
88KAP1_22055183_ChIP-Seq_ESCs_Mouse0.93755220
89RACK7_27058665_Chip-Seq_MCF-7_Human0.93143425
90* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.93044148
91* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.93044148
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92273209
93* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91880200
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91632331
95TFEB_21752829_ChIP-Seq_HELA_Human0.91099748
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90724099
97* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90598681
98* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88874885
99BCL6_27268052_Chip-Seq_Bcells_Human0.88767776
100* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87707565
101SOX2_20726797_ChIP-Seq_SW620_Human0.84540190
102* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84034344
103* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84034344
104PPAR_26484153_Chip-Seq_NCI-H1993_Human0.81748482
105ESR2_21235772_ChIP-Seq_MCF-7_Human0.81035718
106SALL4_18804426_ChIP-ChIP_XEN_Mouse0.80548888
107RARA_24833708_ChIP-Seq_LIVER_Mouse0.80483854
108AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80461616
109EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.79133463
110RAD21_21589869_ChIP-Seq_MESCs_Mouse0.76657026
111FOXO3_23340844_ChIP-Seq_DLD1_Human0.75799054
112PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.75658627
113* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.74625828
114GATA6_25053715_ChIP-Seq_YYC3_Human0.74625115
115PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.72892589
116PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.72631562
117ESR1_21235772_ChIP-Seq_MCF-7_Human0.72313694
118GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.70707107
119FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.69475474
120STAT1_17558387_ChIP-Seq_HELA_Human0.69390546
121EGR1_19032775_ChIP-ChIP_M12_Human0.68916510
122CEBPB_22108803_ChIP-Seq_LS180_Human0.68848101
123GATA2_21666600_ChIP-Seq_HMVEC_Human0.68728692
124BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.67926224
125* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67701446
126AUTS2_25519132_ChIP-Seq_293T-REX_Human0.67029995
127FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.66843449
128GATA2_19941826_ChIP-Seq_K562_Human0.66581008
129FOXA1_25552417_ChIP-Seq_VCAP_Human0.65771634
130CDX2_19796622_ChIP-Seq_MESCs_Mouse0.65489414
131* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.65060362
132RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.64843873
133BP1_19119308_ChIP-ChIP_Hs578T_Human0.64597931
134* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.64120565
135PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.63266821
136PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.62976851
137CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.61831189
138PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.61740778
139CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.61582101
140RARB_24833708_ChIP-Seq_LIVER_Mouse0.60767304
141TRIM28_21343339_ChIP-Seq_HEK293_Human0.60270076
142* AR_20517297_ChIP-Seq_VCAP_Human0.59740769
143CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.59393374
144LXR_22292898_ChIP-Seq_THP-1_Human0.59318130
145ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.59119175
146ESET_19884257_ChIP-Seq_ESCs_Mouse0.59056521
147FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.57939241
148CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.57902520
149P53_21459846_ChIP-Seq_SAOS-2_Human0.57427157
150MYC_19915707_ChIP-ChIP_AK7_Human0.57227582
151ESR1_20079471_ChIP-ChIP_T-47D_Human0.56537443
152PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.55154965
153SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.54803803
154* GATA1_19941826_ChIP-Seq_K562_Human0.54634015
155LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.54534876
156CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.53247060
157NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.52605942
158PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.52329971

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.29834158
2MP0005360_urolithiasis6.76344272
3MP0005085_abnormal_gallbladder_physiolo5.66851365
4MP0005365_abnormal_bile_salt5.52259684
5MP0008875_abnormal_xenobiotic_pharmacok4.77352710
6MP0003303_peritoneal_inflammation4.17679842
7MP0003806_abnormal_nucleotide_metabolis3.85283681
8MP0003252_abnormal_bile_duct3.55350924
9MP0010329_abnormal_lipoprotein_level3.28531667
10MP0002148_abnormal_hypersensitivity_rea3.14372566
11MP0009840_abnormal_foam_cell3.00227996
12MP0003195_calcinosis2.66576343
13MP0001666_abnormal_nutrient_absorption2.65911054
14MP0005387_immune_system_phenotype2.65247080
15MP0001790_abnormal_immune_system2.65247080
16MP0005083_abnormal_biliary_tract2.62081572
17MP0003191_abnormal_cellular_cholesterol2.61363398
18MP0005000_abnormal_immune_tolerance2.60506739
19MP0005671_abnormal_response_to2.60011980
20MP0005332_abnormal_amino_acid2.56701036
21MP0000685_abnormal_immune_system2.18170143
22MP0004510_myositis2.17552108
23MP0002452_abnormal_antigen_presenting2.13605578
24MP0001800_abnormal_humoral_immune2.13459335
25MP0004019_abnormal_vitamin_homeostasis2.13173750
26MP0002723_abnormal_immune_serum2.09693728
27MP0000609_abnormal_liver_physiology2.07532631
28MP0002118_abnormal_lipid_homeostasis2.04348727
29MP0002138_abnormal_hepatobiliary_system2.00235560
30MP0003172_abnormal_lysosome_physiology1.86598537
31MP0005319_abnormal_enzyme/_coenzyme1.84577330
32MP0001819_abnormal_immune_cell1.82054925
33MP0002420_abnormal_adaptive_immunity1.81991751
34MP0003868_abnormal_feces_composition1.73276482
35MP0002405_respiratory_system_inflammati1.62921194
36MP0001764_abnormal_homeostasis1.62257214
37MP0009333_abnormal_splenocyte_physiolog1.59205342
38MP0005584_abnormal_enzyme/coenzyme_acti1.57505203
39MP0009643_abnormal_urine_homeostasis1.52785252
40MP0009278_abnormal_bone_marrow1.51756100
41MP0002998_abnormal_bone_remodeling1.51308533
42MP0003186_abnormal_redox_activity1.49864111
43MP0003453_abnormal_keratinocyte_physiol1.48810696
44MP0005670_abnormal_white_adipose1.47448530
45MP0000858_altered_metastatic_potential1.46210138
46MP0003448_altered_tumor_morphology1.45362212
47MP0006054_spinal_hemorrhage1.42823105
48MP0005310_abnormal_salivary_gland1.42502936
49MP0008004_abnormal_stomach_pH1.36469777
50MP0003705_abnormal_hypodermis_morpholog1.32536018
51MP0009764_decreased_sensitivity_to1.30782124
52MP0000716_abnormal_immune_system1.27895528
53MP0001545_abnormal_hematopoietic_system1.27556024
54MP0005397_hematopoietic_system_phenotyp1.27556024
55MP0003724_increased_susceptibility_to1.24246374
56MP0009697_abnormal_copulation1.23717696
57MP0005451_abnormal_body_composition1.23624713
58MP0008260_abnormal_autophagy1.20818535
59MP0005636_abnormal_mineral_homeostasis1.19421935
60MP0003763_abnormal_thymus_physiology1.19417432
61MP0003656_abnormal_erythrocyte_physiolo1.17148551
62MP0008469_abnormal_protein_level1.12945965
63MP0000598_abnormal_liver_morphology1.10284806
64MP0002398_abnormal_bone_marrow1.08796666
65MP0004130_abnormal_muscle_cell1.08304139
66MP0003436_decreased_susceptibility_to1.06221687
67MP0000604_amyloidosis1.06161091
68MP0009763_increased_sensitivity_to1.05145037
69MP0003011_delayed_dark_adaptation1.04723937
70MP0003183_abnormal_peptide_metabolism1.04517662
71MP0001873_stomach_inflammation1.03844915
72MP0005647_abnormal_sex_gland0.99705577
73MP0002429_abnormal_blood_cell0.97872086
74MP0003866_abnormal_defecation0.97731572
75MP0002332_abnormal_exercise_endurance0.97591169
76MP0002254_reproductive_system_inflammat0.96922180
77MP0002877_abnormal_melanocyte_morpholog0.96321220
78MP0005165_increased_susceptibility_to0.95691186
79MP0005058_abnormal_lysosome_morphology0.95423421
80MP0005023_abnormal_wound_healing0.95305629
81MP0003828_pulmonary_edema0.95244011
82MP0003091_abnormal_cell_migration0.93481264
83MP0000689_abnormal_spleen_morphology0.92044965
84MP0009642_abnormal_blood_homeostasis0.91569099
85MP0000465_gastrointestinal_hemorrhage0.90964816
86MP0005390_skeleton_phenotype0.88674715
87MP0002971_abnormal_brown_adipose0.88273175
88MP0006036_abnormal_mitochondrial_physio0.87519392
89MP0002722_abnormal_immune_system0.87402059
90MP0005410_abnormal_fertilization0.85493059
91MP0005167_abnormal_blood-brain_barrier0.85039626
92MP0009785_altered_susceptibility_to0.83233175
93MP0005334_abnormal_fat_pad0.82518186
94MP0010368_abnormal_lymphatic_system0.82490213
95MP0002078_abnormal_glucose_homeostasis0.81705112
96MP0005376_homeostasis/metabolism_phenot0.81532072
97MP0005464_abnormal_platelet_physiology0.81149749
98MP0005666_abnormal_adipose_tissue0.80595817
99MP0001756_abnormal_urination0.80505535
100MP0001542_abnormal_bone_strength0.80097781
101MP0005084_abnormal_gallbladder_morpholo0.80021827
102MP0002933_joint_inflammation0.79529986
103MP0006082_CNS_inflammation0.78032417
104MP0004782_abnormal_surfactant_physiolog0.77165206
105MP0003075_altered_response_to0.75681327
106MP0003795_abnormal_bone_structure0.75312845
107MP0003690_abnormal_glial_cell0.74639374
108MP0005408_hypopigmentation0.74559750
109MP0002876_abnormal_thyroid_physiology0.73764544
110MP0001851_eye_inflammation0.73501836
111MP0002136_abnormal_kidney_physiology0.73086365
112MP0002837_dystrophic_cardiac_calcinosis0.72991212
113MP0000490_abnormal_crypts_of0.71305622
114MP0005535_abnormal_body_temperature0.71140101
115MP0005166_decreased_susceptibility_to0.70090688
116MP0001845_abnormal_inflammatory_respons0.68646654
117MP0009765_abnormal_xenobiotic_induced0.68331950
118MP0008874_decreased_physiological_sensi0.68310253
119MP0010352_gastrointestinal_tract_polyps0.67607263
120MP0003045_fibrosis0.67065755
121MP0005220_abnormal_exocrine_pancreas0.66729496
122MP0002277_abnormal_respiratory_mucosa0.66165834
123MP0000920_abnormal_myelination0.65819343
124MP0003300_gastrointestinal_ulcer0.65406422
125MP0001216_abnormal_epidermal_layer0.64402442
126MP0002166_altered_tumor_susceptibility0.64379367
127MP0004043_abnormal_pH_regulation0.63440643
128MP0002419_abnormal_innate_immunity0.63012659
129MP0010234_abnormal_vibrissa_follicle0.62534306
130MP0002006_tumorigenesis0.62066634
131MP0001853_heart_inflammation0.61949002
132MP0005448_abnormal_energy_balance0.61632623
133MP0010155_abnormal_intestine_physiology0.61548635
134MP0005025_abnormal_response_to0.61279188
135MP0001661_extended_life_span0.60218453
136MP0001765_abnormal_ion_homeostasis0.59108040
137MP0005266_abnormal_metabolism0.59102468
138MP0004264_abnormal_extraembryonic_tissu0.58457575
139MP0009115_abnormal_fat_cell0.56496066
140MP0001533_abnormal_skeleton_physiology0.56013977
141MP0000249_abnormal_blood_vessel0.55537580
142MP0005164_abnormal_response_to0.53539683
143MP0008873_increased_physiological_sensi0.50697085
144MP0004947_skin_inflammation0.50353710
145MP0003638_abnormal_response/metabolism_0.47908469
146MP0002928_abnormal_bile_duct0.47319881
147MP0001663_abnormal_digestive_system0.46710005
148MP0000230_abnormal_systemic_arterial0.46032569
149MP0001835_abnormal_antigen_presentation0.45816829
150MP0002060_abnormal_skin_morphology0.45557389
151MP0003953_abnormal_hormone_level0.45042163
152MP0004883_abnormal_blood_vessel0.44582945
153MP0002132_abnormal_respiratory_system0.44443612
154MP0000343_altered_response_to0.42440673
155MP0003329_amyloid_beta_deposits0.42047877
156MP0002168_other_aberrant_phenotype0.40162333
157MP0006035_abnormal_mitochondrial_morpho0.39603353

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.45058442
2Intrahepatic cholestasis (HP:0001406)6.41163696
3Deep venous thrombosis (HP:0002625)6.25220673
4Abnormality of glycolipid metabolism (HP:0010969)5.97242571
5Abnormality of liposaccharide metabolism (HP:0010968)5.97242571
6Abnormality of glycosphingolipid metabolism (HP:0004343)5.97242571
7Abnormality of monocarboxylic acid metabolism (HP:0010996)5.90670909
8Xanthomatosis (HP:0000991)5.68756308
9Prolonged partial thromboplastin time (HP:0003645)5.62194019
10Hypobetalipoproteinemia (HP:0003563)5.35964794
11Abnormality of macrophages (HP:0004311)4.98446904
12Complement deficiency (HP:0004431)4.95560082
13Hyperlipoproteinemia (HP:0010980)4.84116918
14Eczematoid dermatitis (HP:0000976)4.75930066
15Recurrent bacterial skin infections (HP:0005406)4.57293360
16Joint hemorrhage (HP:0005261)4.37083372
17Recurrent abscess formation (HP:0002722)4.35823219
18Hyperammonemia (HP:0001987)4.32900916
19Hypolipoproteinemia (HP:0010981)4.26376596
20Vacuolated lymphocytes (HP:0001922)4.24713119
21Abnormality of the common coagulation pathway (HP:0010990)4.13143168
22Ketosis (HP:0001946)4.11532633
23Hypoglycemic coma (HP:0001325)4.11465410
24Orchitis (HP:0100796)4.09912962
25Abnormality of glutamine family amino acid metabolism (HP:0010902)4.08084174
26Myositis (HP:0100614)4.04051365
27Epidermoid cyst (HP:0200040)3.99666986
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.95761405
29Hypoalphalipoproteinemia (HP:0003233)3.92089231
30Hyperglycinemia (HP:0002154)3.89800027
31Optic neuritis (HP:0100653)3.86992316
32Retrobulbar optic neuritis (HP:0100654)3.86992316
33Fat malabsorption (HP:0002630)3.84926604
34Dysostosis multiplex (HP:0000943)3.76567415
35Abnormality of complement system (HP:0005339)3.75521307
36Hyperglycinuria (HP:0003108)3.74343338
37Increased cerebral lipofuscin (HP:0011813)3.72014793
38Abnormality of sulfur amino acid metabolism (HP:0004339)3.68947461
39Abnormality of glycine metabolism (HP:0010895)3.64294515
40Abnormality of serine family amino acid metabolism (HP:0010894)3.64294515
41Conjugated hyperbilirubinemia (HP:0002908)3.61868944
42Abnormality of aspartate family amino acid metabolism (HP:0010899)3.60709039
43Loss of speech (HP:0002371)3.60394346
44Abnormality of the intrinsic pathway (HP:0010989)3.57161558
45Abnormality of fatty-acid metabolism (HP:0004359)3.55811429
46Stomatitis (HP:0010280)3.52286058
47Hypercholesterolemia (HP:0003124)3.42478764
48Abnormality of methionine metabolism (HP:0010901)3.40197589
49Mediastinal lymphadenopathy (HP:0100721)3.38617181
50Disinhibition (HP:0000734)3.32358160
51Systemic lupus erythematosus (HP:0002725)3.28420997
52Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.27487185
53Autoimmune thrombocytopenia (HP:0001973)3.23135377
54Ketoacidosis (HP:0001993)3.13513169
55Abnormality of pyrimidine metabolism (HP:0004353)3.10029374
56Recurrent gram-negative bacterial infections (HP:0005420)3.07860192
57Hyperbilirubinemia (HP:0002904)3.04521686
58Myocardial infarction (HP:0001658)3.02838189
59Elevated erythrocyte sedimentation rate (HP:0003565)3.02521763
60Abnormality of nucleobase metabolism (HP:0010932)3.01371767
61Increased neuronal autofluorescent lipopigment (HP:0002074)3.00826193
62Abnormality of purine metabolism (HP:0004352)2.97042964
63Abnormality of mucopolysaccharide metabolism (HP:0011020)2.95268124
64Abnormality of polysaccharide metabolism (HP:0011012)2.95268124
65Abnormality of glycosaminoglycan metabolism (HP:0004371)2.95268124
66Dicarboxylic aciduria (HP:0003215)2.86277862
67Abnormality of dicarboxylic acid metabolism (HP:0010995)2.86277862
68Mucopolysacchariduria (HP:0008155)2.86149814
69Urinary glycosaminoglycan excretion (HP:0003541)2.86149814
70Steatorrhea (HP:0002570)2.85604673
71Keratoconjunctivitis sicca (HP:0001097)2.82168184
72Pulmonary infiltrates (HP:0002113)2.78636339
73Vascular calcification (HP:0004934)2.77547931
74Metabolic acidosis (HP:0001942)2.77181067
75Obstructive lung disease (HP:0006536)2.74308992
76Chronic obstructive pulmonary disease (HP:0006510)2.74308992
77Recurrent skin infections (HP:0001581)2.71359837
78Vasculitis (HP:0002633)2.68535449
79Glomerulonephritis (HP:0000099)2.68497666
80Hepatocellular carcinoma (HP:0001402)2.64925546
81Abnormality of serum amino acid levels (HP:0003112)2.62864918
82Increased serum ferritin (HP:0003281)2.62862978
83Increased IgM level (HP:0003496)2.61979754
84Hypoglycemic seizures (HP:0002173)2.61629710
85Recurrent fungal infections (HP:0002841)2.61558450
86Skin nodule (HP:0200036)2.60661945
87Neurofibrillary tangles (HP:0002185)2.59148917
88Gingivitis (HP:0000230)2.57692201
89Generalized aminoaciduria (HP:0002909)2.55312282
90Petechiae (HP:0000967)2.55021663
91Keratoconjunctivitis (HP:0001096)2.54675761
92Gout (HP:0001997)2.54596778
93Spontaneous abortion (HP:0005268)2.53646910
94Mutism (HP:0002300)2.53386808
95Cardiovascular calcification (HP:0011915)2.52057967
96Hemoptysis (HP:0002105)2.51896148
97Nuclear cataract (HP:0100018)2.51314415
98Lethargy (HP:0001254)2.51110310
99T lymphocytopenia (HP:0005403)2.50704462
100Delayed CNS myelination (HP:0002188)2.49697707
101Purpura (HP:0000979)2.48294637
102Malnutrition (HP:0004395)2.47758057
103Interstitial pulmonary disease (HP:0006530)2.43906761
104Progressive neurologic deterioration (HP:0002344)2.43780600
105Esophageal varix (HP:0002040)2.42954271
106Urticaria (HP:0001025)2.42256167
107Pancreatitis (HP:0001733)2.41528032
108Abnormality of T cell number (HP:0011839)2.41042857
109Meningitis (HP:0001287)2.39233317
110Recurrent viral infections (HP:0004429)2.35228539
111Hepatosplenomegaly (HP:0001433)2.34544529
112Gastrointestinal infarctions (HP:0005244)2.33511719
113Hematochezia (HP:0002573)2.31995227
114Cerebral edema (HP:0002181)2.28238228
115Gangrene (HP:0100758)2.27334330
116Acanthocytosis (HP:0001927)2.25197353
117Increased IgE level (HP:0003212)2.24978514
118Spontaneous hematomas (HP:0007420)2.24889495
119Hemorrhage of the eye (HP:0011885)2.24490187
120Late onset (HP:0003584)2.23746288
121Autoimmune hemolytic anemia (HP:0001890)2.22739823
122Hypergammaglobulinemia (HP:0010702)2.22629615
123Amyloidosis (HP:0011034)2.20831233
124Abnormality of proline metabolism (HP:0010907)2.20590015
125Hydroxyprolinuria (HP:0003080)2.20590015
126Hyperinsulinemic hypoglycemia (HP:0000825)2.19493708
127Abnormality of the vasculature of the conjunctiva (HP:0008054)2.19418487
128Gingival bleeding (HP:0000225)2.17242604
129Vomiting (HP:0002013)2.16023407
130Cholecystitis (HP:0001082)2.14615831
131Abnormal gallbladder physiology (HP:0012438)2.14615831
132Irritability (HP:0000737)2.14491301
133Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.13915867
134Menorrhagia (HP:0000132)2.12217874
135Encephalitis (HP:0002383)2.11403700
136Abnormal gallbladder morphology (HP:0012437)2.11014701
137Spastic diplegia (HP:0001264)2.08578379
138Alkalosis (HP:0001948)2.07924150
139Sensorimotor neuropathy (HP:0007141)2.07648345
140Proximal tubulopathy (HP:0000114)2.07127167
141Nephritis (HP:0000123)2.05874991
142Pustule (HP:0200039)2.05581632
143Polyneuropathy (HP:0001271)2.04328435
144Cholelithiasis (HP:0001081)2.04262757
145Mitral stenosis (HP:0001718)2.04243344
146Apathy (HP:0000741)2.02404344
147Abnormal cartilage morphology (HP:0002763)2.00857523
148Abnormality of iron homeostasis (HP:0011031)2.00652989
149Renal cortical cysts (HP:0000803)2.00426556
150Diminished motivation (HP:0000745)1.99661869
151Nausea (HP:0002018)1.99385304
152Abnormality of transition element cation homeostasis (HP:0011030)1.98714909
153Basal ganglia calcification (HP:0002135)1.98236320
154Asymmetric septal hypertrophy (HP:0001670)1.97736392
155Premature loss of primary teeth (HP:0006323)1.96677059
156Arterial thrombosis (HP:0004420)1.95859685
157Thrombophlebitis (HP:0004418)1.95823077
158Increased purine levels (HP:0004368)1.93490995
159Hyperuricemia (HP:0002149)1.93490995
160Metaphyseal irregularity (HP:0003025)1.92422968
161Leukocytosis (HP:0001974)1.91640103
162Recurrent cutaneous fungal infections (HP:0011370)1.91201232
163Chronic mucocutaneous candidiasis (HP:0002728)1.91201232
164Symptomatic seizures (HP:0011145)1.91158000
165Anorexia (HP:0002039)1.89956640
166Cerebral inclusion bodies (HP:0100314)1.88965686
167Joint swelling (HP:0001386)1.88886219
168Abnormal enzyme/coenzyme activity (HP:0012379)1.87459084
169Enlarged kidneys (HP:0000105)1.87016633
170Hypertriglyceridemia (HP:0002155)1.86748530
171Bone pain (HP:0002653)1.86729272
172Cellulitis (HP:0100658)1.86649667
173Abnormality of the nasal mucosa (HP:0000433)1.86001468
174Pulmonary embolism (HP:0002204)1.85415567
175Chronic diarrhea (HP:0002028)1.85099944
176Neonatal onset (HP:0003623)1.84541077
177Hypochromic microcytic anemia (HP:0004840)1.84039891
178Abnormal delayed hypersensitivity skin test (HP:0002963)1.82722738
179Axonal loss (HP:0003447)1.82382887
180Glomerulopathy (HP:0100820)1.82036116
181Abnormality of the pleura (HP:0002103)1.81925696
182Elevated hepatic transaminases (HP:0002910)1.81557652
183Glycosuria (HP:0003076)1.81470558
184Abnormality of urine glucose concentration (HP:0011016)1.81470558
185Prolonged neonatal jaundice (HP:0006579)1.79755534
186Arthralgia (HP:0002829)1.79710653
187Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.79623711
188Neuronal loss in central nervous system (HP:0002529)1.78798658
189Abnormality of the pericardium (HP:0001697)1.77947283

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.16639479
2ERN14.05972937
3SIK13.30863077
4FGFR43.05489779
5MST1R3.01821539
6RIPK42.80897722
7TAOK32.62522775
8INSRR2.55594743
9GRK72.54413924
10PDK32.48776843
11PDK42.48776843
12FRK2.41029779
13TAOK22.19547024
14TRIB32.14535869
15PRPF4B2.09698147
16MATK2.06539768
17PDK21.91016502
18DDR21.87909073
19PKN21.87581526
20PIK3CG1.75382541
21ERBB41.74966750
22TAOK11.72081118
23TXK1.71894856
24TYK21.71114025
25FGR1.68538862
26TBK11.67886054
27FLT31.67481555
28TGFBR21.54645506
29PTK61.54451689
30IRAK31.49044349
31NEK91.45665209
32PIK3CA1.42537201
33MAP3K131.42255857
34MAP3K31.42025066
35MOS1.40889513
36BMPR21.39808522
37PIM21.39304525
38MAP2K31.38960114
39MAP3K141.38154762
40TESK21.37611513
41MAPK111.27394421
42EPHB11.25000037
43KDR1.24141596
44CDC42BPA1.23962053
45SYK1.17351730
46ACVR1B1.17162161
47CAMK1D1.16935406
48ABL21.16551184
49JAK11.15539799
50TESK11.14931686
51CSK1.10310258
52LYN1.09339486
53JAK21.07759261
54MET1.07284573
55PRKAA21.07253105
56TIE11.06645242
57MYLK1.06164140
58LATS11.05933071
59RIPK11.02812093
60FES0.99742585
61PRKG20.97640423
62SIK30.95241193
63HCK0.89819818
64MAP2K20.88037794
65LCK0.87261934
66ADRBK20.84711068
67MAP2K40.84110190
68LMTK20.83575686
69STK100.83340392
70CHUK0.83014820
71PDPK10.78427793
72PBK0.76386537
73MAPK150.75850419
74IKBKE0.75199540
75ARAF0.74990185
76PINK10.71174303
77MAP3K70.70734662
78BLK0.69582011
79DYRK1B0.69096788
80PDK10.69070689
81WNK40.68533604
82MAP3K100.68473792
83CAMKK20.65414944
84MAP3K20.64650452
85PAK40.64192960
86CSF1R0.64112297
87ZAP700.63869159
88IRAK20.63735399
89PTK20.63206122
90STK38L0.63170048
91PRKAA10.62827073
92GRK60.62336979
93MAPK40.62206015
94MARK30.61969059
95GSK3A0.61066165
96MAP2K10.60450556
97EPHA30.60165508
98MAP2K60.60091944
99TTN0.59655880
100MAP3K120.59173157
101PRKACG0.58621059
102MAP3K110.58318129
103CAMK1G0.56121122
104ICK0.55167943
105CDK60.54110638
106MAP3K10.54082203
107ERBB20.53754937
108TNK20.52844728
109STK240.51038210
110KIT0.49196096
111PRKCZ0.48498886
112BMX0.47860198
113MAPK120.46935660
114IGF1R0.46770654
115FGFR30.45285895
116IRAK40.44893364
117IRAK10.41939784
118PIM10.41857351
119MAP4K10.41486513
120FGFR20.41094862
121GRK10.40839462
122JAK30.40817455
123CAMK2G0.40236174
124BTK0.40028644
125PRKCQ0.39612257
126IKBKB0.39307485
127LIMK10.38802785
128MAPKAPK20.38710576
129PDGFRA0.38623614
130TRPM70.37550732
131PTK2B0.37436450
132KSR20.37424317
133MAP3K50.37224156
134MAP3K60.37074002
135TEC0.37038226
136STK30.36858357
137NME20.36352150
138ABL10.36059489
139CLK10.36028928
140ITK0.35837241
141DAPK20.35717235
142MAPK70.34990892
143HIPK20.34805864
144LRRK20.34722488
145FYN0.34605198
146PDGFRB0.31620676
147RPS6KL10.31499430
148RPS6KC10.31499430
149EPHA20.31466828

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.93823520
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.31039547
3Nitrogen metabolism_Homo sapiens_hsa009103.19308481
4Allograft rejection_Homo sapiens_hsa053302.81576048
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.73298146
6Arginine biosynthesis_Homo sapiens_hsa002202.69003809
7Fatty acid degradation_Homo sapiens_hsa000712.66105019
8Leishmaniasis_Homo sapiens_hsa051402.65521422
9Tryptophan metabolism_Homo sapiens_hsa003802.62520171
10Complement and coagulation cascades_Homo sapiens_hsa046102.58282871
11Osteoclast differentiation_Homo sapiens_hsa043802.57000687
12Graft-versus-host disease_Homo sapiens_hsa053322.55906644
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.46884977
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.43604450
15Rheumatoid arthritis_Homo sapiens_hsa053232.43039419
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.42958763
17Asthma_Homo sapiens_hsa053102.39960516
18Autoimmune thyroid disease_Homo sapiens_hsa053202.35805619
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.35524841
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.23884962
21Caffeine metabolism_Homo sapiens_hsa002322.22709627
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.19068481
23Propanoate metabolism_Homo sapiens_hsa006402.18530214
24NF-kappa B signaling pathway_Homo sapiens_hsa040642.18281907
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.15222698
26Intestinal immune network for IgA production_Homo sapiens_hsa046722.11001935
27Peroxisome_Homo sapiens_hsa041462.07772184
28PPAR signaling pathway_Homo sapiens_hsa033202.05090391
29Tuberculosis_Homo sapiens_hsa051522.03349956
30Butanoate metabolism_Homo sapiens_hsa006502.02118732
31Chemical carcinogenesis_Homo sapiens_hsa052042.01593266
32Histidine metabolism_Homo sapiens_hsa003402.01557373
33Staphylococcus aureus infection_Homo sapiens_hsa051502.00612011
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.98197648
35Type I diabetes mellitus_Homo sapiens_hsa049401.96665667
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.93552656
37TNF signaling pathway_Homo sapiens_hsa046681.93399076
38Fatty acid metabolism_Homo sapiens_hsa012121.87760133
39Antigen processing and presentation_Homo sapiens_hsa046121.80103823
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.76993291
41beta-Alanine metabolism_Homo sapiens_hsa004101.71786004
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.63725284
43Influenza A_Homo sapiens_hsa051641.63125344
44Toxoplasmosis_Homo sapiens_hsa051451.62515103
45Hematopoietic cell lineage_Homo sapiens_hsa046401.62263605
46Retinol metabolism_Homo sapiens_hsa008301.62086193
47Salmonella infection_Homo sapiens_hsa051321.61870728
48Selenocompound metabolism_Homo sapiens_hsa004501.57692476
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.55243453
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54220556
51Phenylalanine metabolism_Homo sapiens_hsa003601.53874255
52Bile secretion_Homo sapiens_hsa049761.51299592
53Pyruvate metabolism_Homo sapiens_hsa006201.49999644
54* Sulfur metabolism_Homo sapiens_hsa009201.49233115
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47141854
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.46426033
57Viral myocarditis_Homo sapiens_hsa054161.43809590
58Starch and sucrose metabolism_Homo sapiens_hsa005001.42498301
59Phagosome_Homo sapiens_hsa041451.42250106
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39529863
61Measles_Homo sapiens_hsa051621.37437955
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36001528
63Fat digestion and absorption_Homo sapiens_hsa049751.35383072
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.34912098
65Tyrosine metabolism_Homo sapiens_hsa003501.32975568
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.31942309
67B cell receptor signaling pathway_Homo sapiens_hsa046621.28908596
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27896820
69ABC transporters_Homo sapiens_hsa020101.25604519
70Herpes simplex infection_Homo sapiens_hsa051681.25317072
71Folate biosynthesis_Homo sapiens_hsa007901.22923622
72Carbon metabolism_Homo sapiens_hsa012001.22554118
73Primary immunodeficiency_Homo sapiens_hsa053401.22384080
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.21361765
75Chemokine signaling pathway_Homo sapiens_hsa040621.18851254
76Fatty acid elongation_Homo sapiens_hsa000621.17203519
77Maturity onset diabetes of the young_Homo sapiens_hsa049501.16635010
78Shigellosis_Homo sapiens_hsa051311.15253803
79Jak-STAT signaling pathway_Homo sapiens_hsa046301.13511141
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09814301
81Cysteine and methionine metabolism_Homo sapiens_hsa002701.05058066
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04003212
83Biosynthesis of amino acids_Homo sapiens_hsa012301.02882985
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01561905
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99896738
86Steroid biosynthesis_Homo sapiens_hsa001000.99180319
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98699703
88T cell receptor signaling pathway_Homo sapiens_hsa046600.95722394
89Sulfur relay system_Homo sapiens_hsa041220.95429719
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95163971
91Apoptosis_Homo sapiens_hsa042100.92755109
92Arginine and proline metabolism_Homo sapiens_hsa003300.91263464
93Vitamin digestion and absorption_Homo sapiens_hsa049770.88270144
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88267326
95Acute myeloid leukemia_Homo sapiens_hsa052210.87789649
96Glycerolipid metabolism_Homo sapiens_hsa005610.86702899
97Hepatitis B_Homo sapiens_hsa051610.86407854
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84347116
99Glutathione metabolism_Homo sapiens_hsa004800.84108838
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83061825
101Pentose phosphate pathway_Homo sapiens_hsa000300.78385286
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.77144130
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74216745
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74191669
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73476186
106Fatty acid biosynthesis_Homo sapiens_hsa000610.73273736
107Vitamin B6 metabolism_Homo sapiens_hsa007500.72255182
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.72029694
109Bladder cancer_Homo sapiens_hsa052190.71543266
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67428963
111Collecting duct acid secretion_Homo sapiens_hsa049660.64886672
112Lysine degradation_Homo sapiens_hsa003100.64703423
113Sphingolipid metabolism_Homo sapiens_hsa006000.62113015
114Prolactin signaling pathway_Homo sapiens_hsa049170.55273873
115Epstein-Barr virus infection_Homo sapiens_hsa051690.54907103
116VEGF signaling pathway_Homo sapiens_hsa043700.51025808
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49834605
118Fructose and mannose metabolism_Homo sapiens_hsa000510.48617183
119Metabolic pathways_Homo sapiens_hsa011000.48605832
120Vibrio cholerae infection_Homo sapiens_hsa051100.48448776
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48370764
122Galactose metabolism_Homo sapiens_hsa000520.45971662
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45809553
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.45238580
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44926895
126Endocytosis_Homo sapiens_hsa041440.43592919
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.40008961
128Platelet activation_Homo sapiens_hsa046110.39272067
129Linoleic acid metabolism_Homo sapiens_hsa005910.38437554
130Pancreatic cancer_Homo sapiens_hsa052120.37216656
131Insulin resistance_Homo sapiens_hsa049310.34777367
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33333138
133Systemic lupus erythematosus_Homo sapiens_hsa053220.33120280
134One carbon pool by folate_Homo sapiens_hsa006700.32837825
135HTLV-I infection_Homo sapiens_hsa051660.31805502
136Glycosaminoglycan degradation_Homo sapiens_hsa005310.31611447
137HIF-1 signaling pathway_Homo sapiens_hsa040660.30724742
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.30718505
139Chronic myeloid leukemia_Homo sapiens_hsa052200.28763873
140Prion diseases_Homo sapiens_hsa050200.27637727
141Viral carcinogenesis_Homo sapiens_hsa052030.26252811
142Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24297588
143Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23892100
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.20602045
145Mineral absorption_Homo sapiens_hsa049780.19240446
146Renal cell carcinoma_Homo sapiens_hsa052110.18502113
147Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16363891
148Type II diabetes mellitus_Homo sapiens_hsa049300.15080034
149Glucagon signaling pathway_Homo sapiens_hsa049220.13114592
150GnRH signaling pathway_Homo sapiens_hsa049120.10832825
151Proteoglycans in cancer_Homo sapiens_hsa052050.09344967
152Lysosome_Homo sapiens_hsa041420.08939170
153Legionellosis_Homo sapiens_hsa051340.08588091
154Other glycan degradation_Homo sapiens_hsa005110.08414842
155Renin-angiotensin system_Homo sapiens_hsa046140.07759036
156AMPK signaling pathway_Homo sapiens_hsa041520.06479302
157Pertussis_Homo sapiens_hsa051330.05624351
158Arachidonic acid metabolism_Homo sapiens_hsa005900.04802606
159Carbohydrate digestion and absorption_Homo sapiens_hsa049730.00431868
160Insulin signaling pathway_Homo sapiens_hsa04910-0.1034573
161Toll-like receptor signaling pathway_Homo sapiens_hsa04620-0.1029242
162RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0944104
163Amoebiasis_Homo sapiens_hsa05146-0.0750828
164African trypanosomiasis_Homo sapiens_hsa05143-0.0567182
165Hepatitis C_Homo sapiens_hsa05160-0.0534488
166Malaria_Homo sapiens_hsa05144-0.0493354
167Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0476745
168Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0426132
169Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0068565
170Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0021130

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »