SQSTM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)4.56833097
2daunorubicin metabolic process (GO:0044597)4.05016038
3polyketide metabolic process (GO:0030638)4.05016038
4doxorubicin metabolic process (GO:0044598)4.05016038
5positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.79446585
6barbed-end actin filament capping (GO:0051016)3.67647278
7aminoglycoside antibiotic metabolic process (GO:0030647)3.49345231
8positive regulation of p38MAPK cascade (GO:1900745)3.49199330
9positive regulation of chemokine biosynthetic process (GO:0045080)3.48292505
10glycolipid catabolic process (GO:0019377)3.48146901
11glycosphingolipid catabolic process (GO:0046479)3.45470056
12positive regulation of extracellular matrix organization (GO:1903055)3.43769112
13skin morphogenesis (GO:0043589)3.34759134
14maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.29923957
15regulation of membrane protein ectodomain proteolysis (GO:0051043)3.29009185
16protein retention in ER lumen (GO:0006621)3.21808476
17growth hormone receptor signaling pathway (GO:0060396)3.16409054
18oligosaccharide catabolic process (GO:0009313)3.16303573
19positive regulation of heat generation (GO:0031652)3.13236571
20positive regulation by symbiont of host defense response (GO:0052509)3.08956455
21modulation by symbiont of host defense response (GO:0052031)3.08956455
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.08956455
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.08956455
24positive regulation by organism of defense response of other organism involved in symbiotic interact3.08956455
25modulation by symbiont of host immune response (GO:0052553)3.08956455
26hyaluronan catabolic process (GO:0030214)2.98985092
27neutrophil activation involved in immune response (GO:0002283)2.89261577
28apoptotic cell clearance (GO:0043277)2.89160110
29regulation of cholesterol storage (GO:0010885)2.89061672
30glycoside metabolic process (GO:0016137)2.88285650
31pinocytosis (GO:0006907)2.86396224
32cell adhesion mediated by integrin (GO:0033627)2.86257392
33pentose-phosphate shunt (GO:0006098)2.83486133
34retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.81985745
35cellular response to growth hormone stimulus (GO:0071378)2.81044392
36response to thyroid hormone (GO:0097066)2.80620405
37regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.80406284
38positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.79608869
39positive regulation of endothelial cell apoptotic process (GO:2000353)2.78383634
40epithelial cell-cell adhesion (GO:0090136)2.77626878
41regulation of early endosome to late endosome transport (GO:2000641)2.77257188
42cellular response to thyroid hormone stimulus (GO:0097067)2.76923877
43regulation of podosome assembly (GO:0071801)2.75403340
44lipopolysaccharide-mediated signaling pathway (GO:0031663)2.74794219
45positive regulation of receptor recycling (GO:0001921)2.73971238
46regulation of fever generation (GO:0031620)2.73070383
47protein localization to endosome (GO:0036010)2.72078995
48basement membrane organization (GO:0071711)2.69931503
49JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.69922371
50cyclooxygenase pathway (GO:0019371)2.68954016
51macrophage activation involved in immune response (GO:0002281)2.67131068
52endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.66257456
53positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.66025434
54regulation of p38MAPK cascade (GO:1900744)2.65421781
55response to muramyl dipeptide (GO:0032495)2.65069021
56ceramide catabolic process (GO:0046514)2.63802399
57adhesion of symbiont to host (GO:0044406)2.60633804
58protein hydroxylation (GO:0018126)2.59415127
59membrane lipid catabolic process (GO:0046466)2.58054069
60plasma lipoprotein particle clearance (GO:0034381)2.57465339
61fibrinolysis (GO:0042730)2.56696838
62negative regulation of protein localization to plasma membrane (GO:1903077)2.53725902
63hydrogen peroxide biosynthetic process (GO:0050665)2.53387742
64amino sugar catabolic process (GO:0046348)2.52905801
65response to peptidoglycan (GO:0032494)2.52072208
66progesterone metabolic process (GO:0042448)2.49677496
67cell-substrate junction assembly (GO:0007044)2.48171231
68glucose 6-phosphate metabolic process (GO:0051156)2.47172582
69negative regulation of fibrinolysis (GO:0051918)2.47099818
70positive regulation of macrophage cytokine production (GO:0060907)2.45964868
71mannose metabolic process (GO:0006013)2.45884584
72NADPH regeneration (GO:0006740)2.45018868
73regulation of chemokine biosynthetic process (GO:0045073)2.44229241
74response to laminar fluid shear stress (GO:0034616)2.44164941
75Golgi transport vesicle coating (GO:0048200)2.43925874
76COPI coating of Golgi vesicle (GO:0048205)2.43925874
77antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.43157938
78peptidyl-proline hydroxylation (GO:0019511)2.43014701
79glucose catabolic process (GO:0006007)2.41837140
80hemidesmosome assembly (GO:0031581)2.40972519
81regulation of glucose import in response to insulin stimulus (GO:2001273)2.40681614
82positive regulation of lipid storage (GO:0010884)2.39710955
83negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.39232406
84endodermal cell differentiation (GO:0035987)2.37754363
85regulation of vitamin metabolic process (GO:0030656)2.37553645
86decidualization (GO:0046697)2.36865428
87response to manganese ion (GO:0010042)2.36848960
88regulation of extracellular matrix organization (GO:1903053)2.35358496
89membrane protein ectodomain proteolysis (GO:0006509)2.35009686
90* macroautophagy (GO:0016236)2.34710240
91regulation of heat generation (GO:0031650)2.34680575
92negative regulation of lipid storage (GO:0010888)2.34679258
93activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.34486820
94primary alcohol catabolic process (GO:0034310)2.34232363
95positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.33972411
96sexual reproduction (GO:0019953)2.33951807
97negative regulation of fatty acid biosynthetic process (GO:0045717)2.33862758
98regulation of cholesterol homeostasis (GO:2000188)2.32574453
99sphingolipid catabolic process (GO:0030149)2.32033376
100embryo implantation (GO:0007566)2.29599453
101vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.29509452
102response to arsenic-containing substance (GO:0046685)2.29366517
103regulation of extracellular matrix disassembly (GO:0010715)2.28902773
104negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.28829627
105membrane raft organization (GO:0031579)2.28389549
106hypotonic response (GO:0006971)2.27970201
107keratan sulfate catabolic process (GO:0042340)2.25863166
108glial cell migration (GO:0008347)2.25284534
109regulation of mononuclear cell migration (GO:0071675)2.24448270
110L-alpha-amino acid transmembrane transport (GO:1902475)2.24300986
111cell-substrate adherens junction assembly (GO:0007045)2.23735472
112focal adhesion assembly (GO:0048041)2.23735472
113amyloid precursor protein catabolic process (GO:0042987)2.22255239
114endoplasmic reticulum unfolded protein response (GO:0030968)2.22183581
115negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.21946681
116endocytic recycling (GO:0032456)2.21803108
117adherens junction assembly (GO:0034333)2.21693296
118cellular copper ion homeostasis (GO:0006878)2.21498802
119phagosome maturation (GO:0090382)2.20583166
120NIK/NF-kappaB signaling (GO:0038061)2.20573184
121peptide catabolic process (GO:0043171)2.20409815
122positive regulation of cellular amide metabolic process (GO:0034250)2.20407092
123substrate-dependent cell migration (GO:0006929)2.20241811
124regulation of interleukin-12 biosynthetic process (GO:0045075)2.19616516
125positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.19499809
126regulation of heterotypic cell-cell adhesion (GO:0034114)2.19497295
127positive regulation of triglyceride lipase activity (GO:0061365)2.19490261
128positive regulation of lipoprotein lipase activity (GO:0051006)2.19490261
129activation of MAPKKK activity (GO:0000185)2.19161872
130endothelial cell chemotaxis (GO:0035767)2.18345344
131cellular response to nicotine (GO:0071316)2.17620055
132positive regulation of interferon-alpha production (GO:0032727)2.17196428
133nitric oxide biosynthetic process (GO:0006809)2.17094611
134granulocyte activation (GO:0036230)2.14399576
135wound healing, spreading of epidermal cells (GO:0035313)2.14150946
136regulation of interferon-alpha production (GO:0032647)2.13570538
137positive regulation of nuclease activity (GO:0032075)2.13199286
138cellular response to unfolded protein (GO:0034620)2.12348171
139positive regulation of nitric oxide biosynthetic process (GO:0045429)2.11639058
140regulation of macrophage cytokine production (GO:0010935)2.10241353
141cerebellar Purkinje cell layer development (GO:0021680)2.10228550
142positive regulation of fatty acid biosynthetic process (GO:0045723)2.07690400
143T-helper 1 type immune response (GO:0042088)2.07236672
144regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.06779223
145negative regulation of interleukin-17 production (GO:0032700)2.06597952
146positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.05017517
147negative regulation of cytokine production involved in immune response (GO:0002719)2.05000481
148respiratory burst (GO:0045730)2.04504930
149ER-nucleus signaling pathway (GO:0006984)2.04271094
150plasma membrane repair (GO:0001778)2.03712049
151regulation of interferon-beta biosynthetic process (GO:0045357)2.03669674
152positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.02161604
153regulation of dendritic cell antigen processing and presentation (GO:0002604)2.02130518
154virion attachment to host cell (GO:0019062)2.02042370
155adhesion of symbiont to host cell (GO:0044650)2.02042370
156natural killer cell mediated cytotoxicity (GO:0042267)2.01918052
157natural killer cell mediated immunity (GO:0002228)2.01918052
158regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.01839094
159negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.01476751
160reactive oxygen species biosynthetic process (GO:1903409)2.00812438
161regulation of lipid storage (GO:0010883)2.00485165
162response to host immune response (GO:0052572)1.98872706
163response to immune response of other organism involved in symbiotic interaction (GO:0052564)1.98872706
164positive regulation of leukocyte degranulation (GO:0043302)1.98669854
165regulation of integrin activation (GO:0033623)1.98523176
166myeloid cell homeostasis (GO:0002262)1.97926385
167cellular response to arsenic-containing substance (GO:0071243)1.97808979
168regulation of vascular endothelial growth factor signaling pathway (GO:1900746)1.97497560
169stress fiber assembly (GO:0043149)1.97199785
170cellular response to cadmium ion (GO:0071276)1.96385169
171detection of molecule of bacterial origin (GO:0032490)1.94785503
172cellular response to topologically incorrect protein (GO:0035967)1.94772631
173response to growth hormone (GO:0060416)1.94309767

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.14988481
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.83049166
3IRF8_22096565_ChIP-ChIP_GC-B_Human2.66080662
4* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.62915609
5IRF8_21731497_ChIP-ChIP_J774_Mouse2.53858676
6* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.51106654
7* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.50892338
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.36636877
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.25104999
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.23944559
11* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.21500212
12CLOCK_20551151_ChIP-Seq_293T_Human2.15610898
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.14058737
14* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.06771329
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.04571365
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.01178499
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.00477612
18PPARA_22158963_ChIP-Seq_LIVER_Mouse1.99653790
19* LXR_22158963_ChIP-Seq_LIVER_Mouse1.98839086
20* ESR2_21235772_ChIP-Seq_MCF-7_Human1.94436037
21* IRF8_27001747_Chip-Seq_BMDM_Mouse1.93873717
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.90467126
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.85967303
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.85049617
25VDR_21846776_ChIP-Seq_THP-1_Human1.74377589
26BP1_19119308_ChIP-ChIP_Hs578T_Human1.74321623
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.73553782
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71050473
29* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.70942147
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.70255937
31* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69445908
32TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69082070
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.67744791
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.60635252
35* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.55325216
36* LXR_22292898_ChIP-Seq_THP-1_Human1.54341809
37GATA2_21666600_ChIP-Seq_HMVEC_Human1.48186709
38ESR1_21235772_ChIP-Seq_MCF-7_Human1.47372968
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.45615400
40UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.40978855
41* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40788387
42* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38519431
43* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38519431
44KDM2B_26808549_Chip-Seq_DND41_Human1.36860253
45RACK7_27058665_Chip-Seq_MCF-7_Human1.33716906
46MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.33557300
47HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.32354153
48KDM2B_26808549_Chip-Seq_K562_Human1.28867933
49CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.28795377
50TP53_22127205_ChIP-Seq_IMR90_Human1.28414828
51* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.27866290
52* ATF3_27146783_Chip-Seq_COLON_Human1.27773752
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27596264
54* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.27249158
55* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26453264
56NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.26100189
57UBF1/2_26484160_Chip-Seq_HMECs_Human1.25564471
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.21487269
59SPI1_23127762_ChIP-Seq_K562_Human1.20607382
60ZNF263_19887448_ChIP-Seq_K562_Human1.18895363
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.18768970
62SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18580525
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17730118
64CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17665121
65TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16967628
66* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16002783
67TCF7_22412390_ChIP-Seq_EML_Mouse1.15552209
68JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15198125
69PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14857296
70GATA1_19941826_ChIP-Seq_K562_Human1.14771316
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14679602
72E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14464422
73* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14373498
74MYC_22102868_ChIP-Seq_BL_Human1.13404595
75* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.12727286
76KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11740589
77NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11733266
78PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11440080
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11297982
80KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11059915
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10970383
82VDR_24787735_ChIP-Seq_THP-1_Human1.10689519
83* RUNX1_22412390_ChIP-Seq_EML_Mouse1.09663866
84TET1_21451524_ChIP-Seq_MESCs_Mouse1.09521100
85ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09223631
86KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09056960
87RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09000886
88* SOX2_20726797_ChIP-Seq_SW620_Human1.08699209
89SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08545030
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08370163
91SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07326642
92EGR1_19032775_ChIP-ChIP_M12_Human1.05921654
93TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05713300
94MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04253725
95ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04123808
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03199050
97JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01956336
98SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01587728
99VDR_24763502_ChIP-Seq_THP-1_Human1.01092017
100GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00770029
101SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00685767
102SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00034505
103STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97444637
104NCOR1_26117541_ChIP-Seq_K562_Human0.97386930
105NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97131885
106EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96780910
107DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96265668
108CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96181124
109* MAF_26560356_Chip-Seq_TH1_Human0.95962191
110KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95676719
111SA1_27219007_Chip-Seq_ERYTHROID_Human0.95256063
112GATA1_19941827_ChIP-Seq_MEL_Mouse0.95024873
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94989062
114STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.94815720
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94807516
116ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92524948
117* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.92335141
118STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91366154
119GATA2_19941826_ChIP-Seq_K562_Human0.91150713
120* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90996652
121RUNX_20019798_ChIP-Seq_JUKART_Human0.90000167
122* CJUN_26792858_Chip-Seq_BT549_Human0.89380223
123TFEB_21752829_ChIP-Seq_HELA_Human0.88675574
124SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.88562807
125SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.88562807
126IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88504385
127P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87669467
128KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87619261
129TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.87577780
130* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.87560801
131* TBX20_22328084_ChIP-Seq_HEART_Mouse0.87309936
132* TBX20_22080862_ChIP-Seq_HEART_Mouse0.87309936
133* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86954022

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.51400957
2MP0005451_abnormal_body_composition3.09427752
3MP0005058_abnormal_lysosome_morphology3.02154720
4MP0004510_myositis2.92491509
5MP0009840_abnormal_foam_cell2.52109616
6MP0003172_abnormal_lysosome_physiology2.42030036
7MP0003436_decreased_susceptibility_to2.37993646
8MP0004858_abnormal_nervous_system2.35412904
9MP0003195_calcinosis2.29337862
10MP0003300_gastrointestinal_ulcer2.22005083
11MP0000604_amyloidosis2.14838183
12MP0009785_altered_susceptibility_to2.09629004
13MP0003705_abnormal_hypodermis_morpholog2.08366840
14MP0002877_abnormal_melanocyte_morpholog2.08059569
15MP0002138_abnormal_hepatobiliary_system2.03612284
16MP0003075_altered_response_to1.98266910
17MP0008260_abnormal_autophagy1.94563458
18MP0004947_skin_inflammation1.84684322
19MP0004272_abnormal_basement_membrane1.82612901
20MP0005167_abnormal_blood-brain_barrier1.74232256
21MP0008438_abnormal_cutaneous_collagen1.72920955
22MP0006082_CNS_inflammation1.70149613
23MP0003566_abnormal_cell_adhesion1.67119382
24MP0003329_amyloid_beta_deposits1.66859024
25* MP0002419_abnormal_innate_immunity1.64703227
26MP0003091_abnormal_cell_migration1.64172401
27MP0003191_abnormal_cellular_cholesterol1.60527227
28MP0003279_aneurysm1.59242826
29MP0005000_abnormal_immune_tolerance1.58238469
30MP0001533_abnormal_skeleton_physiology1.56897365
31MP0004233_abnormal_muscle_weight1.56439103
32MP0002139_abnormal_hepatobiliary_system1.55051387
33MP0003724_increased_susceptibility_to1.52694262
34MP0009764_decreased_sensitivity_to1.52609911
35MP0002909_abnormal_adrenal_gland1.51299531
36MP0000343_altered_response_to1.51284547
37MP0005083_abnormal_biliary_tract1.47242273
38MP0002148_abnormal_hypersensitivity_rea1.47105470
39MP0003950_abnormal_plasma_membrane1.47065093
40MP0001849_ear_inflammation1.39954640
41MP0005076_abnormal_cell_differentiation1.39681658
42MP0009278_abnormal_bone_marrow1.37586455
43MP0008961_abnormal_basal_metabolism1.36601380
44MP0000685_abnormal_immune_system1.36349994
45MP0003453_abnormal_keratinocyte_physiol1.36159958
46MP0003448_altered_tumor_morphology1.35937627
47MP0004130_abnormal_muscle_cell1.34796160
48MP0005387_immune_system_phenotype1.31425834
49MP0001790_abnormal_immune_system1.31425834
50MP0005464_abnormal_platelet_physiology1.31213050
51MP0005025_abnormal_response_to1.30779332
52MP0003183_abnormal_peptide_metabolism1.29711551
53MP0001835_abnormal_antigen_presentation1.28663076
54MP0000751_myopathy1.28345445
55* MP0002998_abnormal_bone_remodeling1.26424326
56MP0005164_abnormal_response_to1.21675961
57MP0001845_abnormal_inflammatory_respons1.20622008
58MP0005166_decreased_susceptibility_to1.18460235
59MP0003045_fibrosis1.18260816
60MP0002060_abnormal_skin_morphology1.17591169
61MP0001958_emphysema1.17082330
62MP0003806_abnormal_nucleotide_metabolis1.15766564
63MP0008469_abnormal_protein_level1.15465127
64MP0000013_abnormal_adipose_tissue1.15163265
65MP0003828_pulmonary_edema1.13484611
66MP0001542_abnormal_bone_strength1.11675443
67MP0005257_abnormal_intraocular_pressure1.10894785
68MP0010234_abnormal_vibrissa_follicle1.09679481
69MP0003656_abnormal_erythrocyte_physiolo1.07913478
70MP0003690_abnormal_glial_cell1.07712184
71MP0002254_reproductive_system_inflammat1.07627276
72MP0005023_abnormal_wound_healing1.07185780
73MP0002896_abnormal_bone_mineralization1.06315558
74MP0000609_abnormal_liver_physiology1.04148415
75MP0005275_abnormal_skin_tensile1.02385106
76* MP0002723_abnormal_immune_serum1.00320824
77MP0005360_urolithiasis0.99519793
78* MP0002452_abnormal_antigen_presenting0.98186410
79MP0005319_abnormal_enzyme/_coenzyme0.95675796
80MP0010352_gastrointestinal_tract_polyps0.95451858
81MP0000733_abnormal_muscle_development0.95375057
82MP0002332_abnormal_exercise_endurance0.95281808
83MP0006054_spinal_hemorrhage0.94200760
84MP0000858_altered_metastatic_potential0.93655663
85MP0004185_abnormal_adipocyte_glucose0.93583775
86MP0000750_abnormal_muscle_regeneration0.93110042
87MP0003186_abnormal_redox_activity0.93035065
88MP0001853_heart_inflammation0.91618319
89MP0003252_abnormal_bile_duct0.91072922
90MP0002090_abnormal_vision0.90904960
91MP0005623_abnormal_meninges_morphology0.90901501
92MP0002405_respiratory_system_inflammati0.89747146
93MP0005584_abnormal_enzyme/coenzyme_acti0.89056473
94MP0003221_abnormal_cardiomyocyte_apopto0.88885046
95MP0002118_abnormal_lipid_homeostasis0.88288002
96MP0009333_abnormal_splenocyte_physiolog0.88261198
97MP0000767_abnormal_smooth_muscle0.88212571
98MP0005535_abnormal_body_temperature0.87769720
99MP0000003_abnormal_adipose_tissue0.87024602
100MP0010386_abnormal_urinary_bladder0.85436578
101MP0009643_abnormal_urine_homeostasis0.85247765
102MP0003634_abnormal_glial_cell0.85059865
103MP0005365_abnormal_bile_salt0.84932997
104MP0010329_abnormal_lipoprotein_level0.84609856
105MP0001915_intracranial_hemorrhage0.84566765
106MP0000747_muscle_weakness0.84399941
107MP0000249_abnormal_blood_vessel0.83960154
108MP0001348_abnormal_lacrimal_gland0.83939005
109MP0005390_skeleton_phenotype0.83316482
110MP0005595_abnormal_vascular_smooth0.82691071
111MP0008875_abnormal_xenobiotic_pharmacok0.82484544
112MP0001501_abnormal_sleep_pattern0.82456930
113MP0001243_abnormal_dermal_layer0.82367088
114MP0002796_impaired_skin_barrier0.81789086
115MP0005332_abnormal_amino_acid0.81678366
116MP0010155_abnormal_intestine_physiology0.81111366
117MP0005666_abnormal_adipose_tissue0.80645588
118MP0005165_increased_susceptibility_to0.79752552
119MP0008874_decreased_physiological_sensi0.79509919
120MP0002168_other_aberrant_phenotype0.79381365
121MP0000759_abnormal_skeletal_muscle0.78815306
122MP0003283_abnormal_digestive_organ0.78445681
123* MP0002078_abnormal_glucose_homeostasis0.78274048
124MP0002693_abnormal_pancreas_physiology0.77452778
125MP0002295_abnormal_pulmonary_circulatio0.77305565
126MP0000371_diluted_coat_color0.75638870
127MP0000749_muscle_degeneration0.75505320
128MP0005375_adipose_tissue_phenotype0.74922727
129MP0002837_dystrophic_cardiac_calcinosis0.74265462
130MP0001216_abnormal_epidermal_layer0.74090680
131MP0003868_abnormal_feces_composition0.73585920
132MP0005330_cardiomyopathy0.73485622
133MP0005310_abnormal_salivary_gland0.73098247
134MP0005621_abnormal_cell_physiology0.72576461
135MP0000920_abnormal_myelination0.71952444

Predicted human phenotypes

RankGene SetZ-score
1Increased cerebral lipofuscin (HP:0011813)3.96207411
2Eczematoid dermatitis (HP:0000976)3.72753690
3Dysostosis multiplex (HP:0000943)3.64112841
4* Vertebral compression fractures (HP:0002953)3.42930228
5Mucopolysacchariduria (HP:0008155)3.39114130
6Urinary glycosaminoglycan excretion (HP:0003541)3.39114130
7Axonal loss (HP:0003447)3.37186111
8Increased neuronal autofluorescent lipopigment (HP:0002074)3.32361744
9Recurrent gram-negative bacterial infections (HP:0005420)3.26440505
10Nuclear cataract (HP:0100018)3.24848525
11Abnormality of mucopolysaccharide metabolism (HP:0011020)3.21574869
12Abnormality of polysaccharide metabolism (HP:0011012)3.21574869
13Abnormality of glycosaminoglycan metabolism (HP:0004371)3.21574869
14Distal lower limb muscle weakness (HP:0009053)3.10682509
15Myocardial infarction (HP:0001658)3.07659047
16Abnormality of macrophages (HP:0004311)3.03540839
17Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.87580657
18Vacuolated lymphocytes (HP:0001922)2.86013879
19Interstitial pulmonary disease (HP:0006530)2.76026533
20Osteolytic defects of the hand bones (HP:0009699)2.75491900
21Osteolytic defects of the phalanges of the hand (HP:0009771)2.75491900
22Stomatitis (HP:0010280)2.74278328
23Distal upper limb amyotrophy (HP:0007149)2.71800144
24Upper limb amyotrophy (HP:0009129)2.71800144
25Asymmetric septal hypertrophy (HP:0001670)2.70529041
26Abnormality of liposaccharide metabolism (HP:0010968)2.69472112
27Abnormality of glycosphingolipid metabolism (HP:0004343)2.69472112
28Abnormality of glycolipid metabolism (HP:0010969)2.69472112
29Recurrent abscess formation (HP:0002722)2.68429467
30Amyloidosis (HP:0011034)2.59155068
31Abnormality of complement system (HP:0005339)2.59130709
32Recurrent bacterial skin infections (HP:0005406)2.57892772
33Short nail (HP:0001799)2.55255086
34Orchitis (HP:0100796)2.50522045
35Supranuclear gaze palsy (HP:0000605)2.50352167
36Cerebral aneurysm (HP:0004944)2.43475434
37Hand muscle atrophy (HP:0009130)2.42000798
38Loss of speech (HP:0002371)2.40645330
39Peritonitis (HP:0002586)2.40434556
40Spinal rigidity (HP:0003306)2.37290424
41Abnormality of monocarboxylic acid metabolism (HP:0010996)2.36319549
42Hypercortisolism (HP:0001578)2.32814851
43Complement deficiency (HP:0004431)2.31511103
44Abnormality of aromatic amino acid family metabolism (HP:0004338)2.28605653
45Vascular tortuosity (HP:0004948)2.28445803
46Hyperacusis (HP:0010780)2.28303069
47Prolonged neonatal jaundice (HP:0006579)2.27327720
48Xanthomatosis (HP:0000991)2.27067040
49Neurofibrillary tangles (HP:0002185)2.23956020
50Arterial tortuosity (HP:0005116)2.23216572
51Elevated erythrocyte sedimentation rate (HP:0003565)2.22455578
52Global brain atrophy (HP:0002283)2.22094193
53J-shaped sella turcica (HP:0002680)2.21576662
54Ankle contracture (HP:0006466)2.20042191
55Frequent falls (HP:0002359)2.17865815
56Abnormality of the Achilles tendon (HP:0005109)2.16791207
57Achilles tendon contracture (HP:0001771)2.15791966
58Gingivitis (HP:0000230)2.14403659
59Optic neuritis (HP:0100653)2.12647807
60Retrobulbar optic neuritis (HP:0100654)2.12647807
61Cerebral inclusion bodies (HP:0100314)2.12593332
62Atrophic scars (HP:0001075)2.12303125
63Wormian bones (HP:0002645)2.11812038
64Glomerulonephritis (HP:0000099)2.11784069
65Mitral stenosis (HP:0001718)2.09963939
66Mediastinal lymphadenopathy (HP:0100721)2.07504325
67Turricephaly (HP:0000262)2.07398998
68Broad face (HP:0000283)2.05938574
69Abnormality of the distal phalanges of the toes (HP:0010182)2.05625694
70Mildly elevated creatine phosphokinase (HP:0008180)2.02810053
71Myositis (HP:0100614)2.01797319
72Purpura (HP:0000979)2.01503857
73Centrally nucleated skeletal muscle fibers (HP:0003687)2.01029374
74Autoimmune thrombocytopenia (HP:0001973)2.00938002
75Esophageal varix (HP:0002040)1.99961781
76Cardiovascular calcification (HP:0011915)1.99310653
77Long toe (HP:0010511)1.98997142
78Spondylolisthesis (HP:0003302)1.98903255
79Skin nodule (HP:0200036)1.98841004
80Increased variability in muscle fiber diameter (HP:0003557)1.97683451
81Peripheral demyelination (HP:0011096)1.96142150
82Premature rupture of membranes (HP:0001788)1.95004510
83Vascular calcification (HP:0004934)1.94931843
84Abnormality of the common coagulation pathway (HP:0010990)1.94783241
85Abnormality of skeletal muscle fiber size (HP:0012084)1.93697762
86Natal tooth (HP:0000695)1.93360689
87Fragile skin (HP:0001030)1.93293319
88Systemic lupus erythematosus (HP:0002725)1.91728862
89Muscle fiber splitting (HP:0003555)1.90882067
90Difficulty climbing stairs (HP:0003551)1.89387958
91Hemorrhage of the eye (HP:0011885)1.88802682
92Increased connective tissue (HP:0009025)1.86619267
93Joint stiffness (HP:0001387)1.86449145
94Elbow flexion contracture (HP:0002987)1.85809153
95Sensorimotor neuropathy (HP:0007141)1.85780958
96Type 1 muscle fiber predominance (HP:0003803)1.84450096
97Striae distensae (HP:0001065)1.83793535
98Deep venous thrombosis (HP:0002625)1.83247961
99Aortic aneurysm (HP:0004942)1.82876633
100Aneurysm (HP:0002617)1.82122952
101Blue sclerae (HP:0000592)1.82119247
102Distal lower limb amyotrophy (HP:0008944)1.81036383
103Generalized amyotrophy (HP:0003700)1.80393485
104Increased CSF protein (HP:0002922)1.79060214
105Progressive neurologic deterioration (HP:0002344)1.78853867
106Ulnar bowing (HP:0003031)1.77660263
107Increased serum ferritin (HP:0003281)1.76770448
108Upper motor neuron abnormality (HP:0002127)1.76490733
109Episodic fever (HP:0001954)1.76264521
110Apathy (HP:0000741)1.76213787
111Mitral regurgitation (HP:0001653)1.75051631
112Hematochezia (HP:0002573)1.74760436
113Aortic dissection (HP:0002647)1.74519711
114Cardiomegaly (HP:0001640)1.73853219
115Hyperparathyroidism (HP:0000843)1.71517593
116Arterial thrombosis (HP:0004420)1.71410278
117Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.70853029
118Protrusio acetabuli (HP:0003179)1.70299268
119Back pain (HP:0003418)1.69867144
120Lower limb amyotrophy (HP:0007210)1.69064639
121Bladder diverticulum (HP:0000015)1.68036736
122Conjugated hyperbilirubinemia (HP:0002908)1.67998074
123Hyporeflexia of lower limbs (HP:0002600)1.67700650
124Ovoid vertebral bodies (HP:0003300)1.67297876
125Polycythemia (HP:0001901)1.67093098
126Ketoacidosis (HP:0001993)1.66870350
127Exercise-induced myalgia (HP:0003738)1.66144795
128Urticaria (HP:0001025)1.65605370
129Pathologic fracture (HP:0002756)1.64729866
130Rapidly progressive (HP:0003678)1.63702483
131Abnormality of the periventricular white matter (HP:0002518)1.63039100
132Hypoalphalipoproteinemia (HP:0003233)1.62800869
133EMG: myopathic abnormalities (HP:0003458)1.61097892
134Diminished motivation (HP:0000745)1.61091515
135Neuronal loss in central nervous system (HP:0002529)1.60587099
136Segmental peripheral demyelination/remyelination (HP:0003481)1.59598362
137Persistence of primary teeth (HP:0006335)1.59451547
138Abnormality of iron homeostasis (HP:0011031)1.59369491
139Scapular winging (HP:0003691)1.59288660
140Stroke (HP:0001297)1.56787716
141Exercise-induced muscle cramps (HP:0003710)1.55550031
142Cervical subluxation (HP:0003308)1.54972595
143Cerebral hemorrhage (HP:0001342)1.54756187
144Abnormality of transition element cation homeostasis (HP:0011030)1.54669561
145Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.54616415
146Nephritis (HP:0000123)1.54546117
147Vasculitis (HP:0002633)1.54400941
148Dilatation of the ascending aorta (HP:0005111)1.54371191
149Protuberant abdomen (HP:0001538)1.53997235
150Retinal atrophy (HP:0001105)1.53988264
151* Tetraparesis (HP:0002273)1.52602454
152Gastrointestinal infarctions (HP:0005244)1.51241089

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.24619477
2TRIB33.20562044
3MAP3K142.60483000
4RIPK42.55430363
5NME22.51191436
6PRPF4B2.30608146
7KSR22.25334578
8* TBK12.22069396
9EPHB12.16050542
10IRAK32.11967809
11EPHA32.11349534
12MAP3K92.04969426
13TAOK22.03023840
14RIPK11.94413919
15MAP3K131.92362764
16ICK1.91139117
17BMX1.88332857
18SMG11.71670447
19TTN1.68789796
20TAOK31.65584847
21SIK11.58106889
22JAK11.56252961
23PBK1.54352428
24FGFR41.52909778
25PDGFRA1.45994989
26NTRK11.43817476
27LATS21.43501549
28MST1R1.43299521
29DDR21.42958929
30PTK61.41116829
31MAP3K11.40232543
32PKN21.40192157
33IKBKB1.37506317
34IKBKE1.36967102
35MAP3K21.28266417
36MAP3K111.27516435
37SCYL21.24862372
38TYK21.19076939
39CAMKK21.12371977
40PRKG21.11901185
41JAK31.10369925
42ARAF1.09359618
43ERBB41.08433895
44DAPK31.07807567
45TESK21.07557686
46RET1.07394774
47CHUK1.07262010
48PAK61.04104904
49CDC42BPA1.02846110
50FER1.02397024
51MYLK1.01200388
52JAK20.99779606
53PIM20.99213664
54ABL20.98134317
55CAMKK10.97382720
56PTK20.96826660
57PRKD20.95239193
58MET0.87366374
59CSK0.86007629
60LRRK20.85754017
61EEF2K0.84862381
62FGR0.83976321
63CDK120.82016571
64MOS0.81104944
65PRKD30.79020707
66CAMK1D0.78794610
67MTOR0.78340444
68MAP3K30.77939622
69IRAK40.76342423
70DAPK20.76250274
71TRPM70.76076765
72STK380.75942334
73GRK70.75164926
74MARK30.74881807
75DYRK1B0.73698010
76IRAK20.72062524
77PAK30.71578451
78ALK0.70749342
79PDPK10.69580022
80PRKCH0.67856748
81MATK0.67294403
82PDGFRB0.67132718
83MAP2K10.65363993
84TAOK10.65328575
85PAK20.65223148
86EPHB20.63917520
87RPS6KA20.62961196
88IRAK10.62916966
89SIK30.61604030
90MAP3K50.61125015
91GSK3A0.60749326
92CAMK2G0.59392218
93HCK0.59064902
94MAPK150.58942052
95SIK20.57096676
96MARK20.54746633
97ZAP700.53861554
98MAP3K100.53850828
99WNK40.53794241
100NEK90.52982258
101MAP3K80.52664695
102EPHA20.52385284
103TESK10.51850390
104DMPK0.51703996
105FGFR30.51448903
106MAPK110.51344981
107EGFR0.50621730
108HIPK20.48683924
109CDK60.47793934
110BRAF0.47760835
111BLK0.47019546
112MAPKAPK30.46986525
113FES0.46933946
114KIT0.45840070
115LMTK20.45789131
116KSR10.45660398
117MAP2K30.45222247
118TYRO30.45128390
119ILK0.44632946
120TGFBR20.44203192
121PAK40.43812631
122PDK20.42798446
123CDK90.42586332
124LIMK10.42332975
125PHKG10.42204861
126PHKG20.42204861
127MAPKAPK20.40217461
128PDK10.39717331
129CAMK1G0.39314439
130PRKCZ0.38739238
131ROCK20.35751807
132RPS6KC10.35603643
133RPS6KL10.35603643
134MAPK120.34773482
135MAP3K60.33667347
136MAPK40.33292198
137STK100.33287220

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.76035667
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.18275529
3Leishmaniasis_Homo sapiens_hsa051402.05977622
4Lysosome_Homo sapiens_hsa041422.04332889
5Galactose metabolism_Homo sapiens_hsa000521.72085973
6TNF signaling pathway_Homo sapiens_hsa046681.63278149
7Pentose phosphate pathway_Homo sapiens_hsa000301.60032689
8Toll-like receptor signaling pathway_Homo sapiens_hsa046201.59819189
9* Osteoclast differentiation_Homo sapiens_hsa043801.59597908
10Legionellosis_Homo sapiens_hsa051341.59054343
11Fructose and mannose metabolism_Homo sapiens_hsa000511.56978993
12Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.53106215
13Malaria_Homo sapiens_hsa051441.50847866
14Arginine biosynthesis_Homo sapiens_hsa002201.50775702
15Rheumatoid arthritis_Homo sapiens_hsa053231.49801820
16Staphylococcus aureus infection_Homo sapiens_hsa051501.45888593
17Tuberculosis_Homo sapiens_hsa051521.40331159
18Phagosome_Homo sapiens_hsa041451.38767680
19Type I diabetes mellitus_Homo sapiens_hsa049401.38297555
20Adipocytokine signaling pathway_Homo sapiens_hsa049201.33831134
21Pertussis_Homo sapiens_hsa051331.33493652
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.31052142
23Type II diabetes mellitus_Homo sapiens_hsa049301.26279461
24Collecting duct acid secretion_Homo sapiens_hsa049661.22232002
25Salmonella infection_Homo sapiens_hsa051321.21754271
26Synaptic vesicle cycle_Homo sapiens_hsa047211.21541174
27Prion diseases_Homo sapiens_hsa050201.20963790
28Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.18255831
29Graft-versus-host disease_Homo sapiens_hsa053321.17852227
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.16316618
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.15323432
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.07912085
33Amoebiasis_Homo sapiens_hsa051461.07825147
34Toxoplasmosis_Homo sapiens_hsa051451.07300486
35Phenylalanine metabolism_Homo sapiens_hsa003601.06788681
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06441188
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05929380
38Shigellosis_Homo sapiens_hsa051311.03124743
39ECM-receptor interaction_Homo sapiens_hsa045121.01974488
40Vibrio cholerae infection_Homo sapiens_hsa051101.00831207
41Sphingolipid metabolism_Homo sapiens_hsa006001.00673435
42Vitamin B6 metabolism_Homo sapiens_hsa007501.00007906
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98890361
44Insulin resistance_Homo sapiens_hsa049310.98791992
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96220003
46Apoptosis_Homo sapiens_hsa042100.96117464
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95908628
48Neurotrophin signaling pathway_Homo sapiens_hsa047220.95569205
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92966390
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.89479995
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88028314
52Prolactin signaling pathway_Homo sapiens_hsa049170.87929536
53African trypanosomiasis_Homo sapiens_hsa051430.86446368
54Small cell lung cancer_Homo sapiens_hsa052220.82481236
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81559696
56B cell receptor signaling pathway_Homo sapiens_hsa046620.81196053
57VEGF signaling pathway_Homo sapiens_hsa043700.78842667
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78456254
59Chronic myeloid leukemia_Homo sapiens_hsa052200.78355468
60mTOR signaling pathway_Homo sapiens_hsa041500.77385159
61Chemokine signaling pathway_Homo sapiens_hsa040620.76054351
62Influenza A_Homo sapiens_hsa051640.75145214
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74109339
64Biosynthesis of amino acids_Homo sapiens_hsa012300.73822037
65Allograft rejection_Homo sapiens_hsa053300.73747872
66Sulfur metabolism_Homo sapiens_hsa009200.72897247
67Dorso-ventral axis formation_Homo sapiens_hsa043200.72506414
68Endocytosis_Homo sapiens_hsa041440.72491863
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.72047811
70Acute myeloid leukemia_Homo sapiens_hsa052210.71447079
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71164981
72Complement and coagulation cascades_Homo sapiens_hsa046100.70699836
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69467123
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.68881179
75Carbon metabolism_Homo sapiens_hsa012000.68744119
76Glutathione metabolism_Homo sapiens_hsa004800.67346897
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67190864
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66561414
79Notch signaling pathway_Homo sapiens_hsa043300.66169454
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65832665
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64313770
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64018321
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.62781877
84Measles_Homo sapiens_hsa051620.62309250
85N-Glycan biosynthesis_Homo sapiens_hsa005100.62017926
86Proteoglycans in cancer_Homo sapiens_hsa052050.61657742
87PPAR signaling pathway_Homo sapiens_hsa033200.60394109
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.60105135
89Glioma_Homo sapiens_hsa052140.59206722
90Hepatitis C_Homo sapiens_hsa051600.59182396
91Asthma_Homo sapiens_hsa053100.58918763
92Renal cell carcinoma_Homo sapiens_hsa052110.58366842
93Tyrosine metabolism_Homo sapiens_hsa003500.57965243
94Bladder cancer_Homo sapiens_hsa052190.57863691
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57403088
96Other glycan degradation_Homo sapiens_hsa005110.57379846
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57379073
98Bile secretion_Homo sapiens_hsa049760.56473495
99Non-small cell lung cancer_Homo sapiens_hsa052230.55903883
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.55676109
101Pancreatic cancer_Homo sapiens_hsa052120.55237351
102Focal adhesion_Homo sapiens_hsa045100.55207988
103HIF-1 signaling pathway_Homo sapiens_hsa040660.55187284
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54028681
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.53841856
106Insulin signaling pathway_Homo sapiens_hsa049100.52552667
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51543097
1082-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50635135
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50600475
110Chemical carcinogenesis_Homo sapiens_hsa052040.50147675
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.50074947
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.49701306
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47957427
114Mineral absorption_Homo sapiens_hsa049780.47515964
115Protein digestion and absorption_Homo sapiens_hsa049740.46146013
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45779948
117Fatty acid degradation_Homo sapiens_hsa000710.45558436
118Tryptophan metabolism_Homo sapiens_hsa003800.44890052
119Hepatitis B_Homo sapiens_hsa051610.44703041
120Thyroid cancer_Homo sapiens_hsa052160.44321606
121Endometrial cancer_Homo sapiens_hsa052130.43340823
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43231467
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42478741
124Estrogen signaling pathway_Homo sapiens_hsa049150.42413634
125Viral myocarditis_Homo sapiens_hsa054160.42105948
126GnRH signaling pathway_Homo sapiens_hsa049120.42011824
127Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41561043
128Starch and sucrose metabolism_Homo sapiens_hsa005000.41475710
129Dilated cardiomyopathy_Homo sapiens_hsa054140.40759805
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.39351775
131Platelet activation_Homo sapiens_hsa046110.38974448
132Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38805058
133Caffeine metabolism_Homo sapiens_hsa002320.36797357

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