SRBD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.16275937
2protein localization to kinetochore (GO:0034501)4.83394859
3mitotic chromosome condensation (GO:0007076)4.58591708
4water-soluble vitamin biosynthetic process (GO:0042364)4.56431936
5folic acid-containing compound biosynthetic process (GO:0009396)4.55877790
6DNA double-strand break processing (GO:0000729)4.51228591
7positive regulation of histone H3-K4 methylation (GO:0051571)4.31038464
8nuclear pore organization (GO:0006999)4.29908127
9nuclear pore complex assembly (GO:0051292)4.22155078
10regulation of centriole replication (GO:0046599)4.17676797
11kinetochore organization (GO:0051383)4.11138982
12protein localization to chromosome, centromeric region (GO:0071459)4.04493202
13DNA strand elongation involved in DNA replication (GO:0006271)3.99629245
14DNA replication-dependent nucleosome assembly (GO:0006335)3.99050440
15DNA replication-dependent nucleosome organization (GO:0034723)3.99050440
16mitotic metaphase plate congression (GO:0007080)3.98892318
17DNA duplex unwinding (GO:0032508)3.88689332
18DNA geometric change (GO:0032392)3.88267878
19mitotic sister chromatid cohesion (GO:0007064)3.87561439
20mitotic nuclear envelope disassembly (GO:0007077)3.83735073
21sister chromatid segregation (GO:0000819)3.83606236
22negative regulation of DNA-dependent DNA replication (GO:2000104)3.79661443
23DNA strand elongation (GO:0022616)3.78305656
24DNA replication initiation (GO:0006270)3.77580205
25regulation of spindle organization (GO:0090224)3.75986075
26mitotic sister chromatid segregation (GO:0000070)3.73076296
27metaphase plate congression (GO:0051310)3.72196204
28chromatin remodeling at centromere (GO:0031055)3.72091945
29respiratory chain complex IV assembly (GO:0008535)3.69458679
30replication fork processing (GO:0031297)3.65344290
31CENP-A containing nucleosome assembly (GO:0034080)3.64886719
32DNA replication checkpoint (GO:0000076)3.63394341
33pre-miRNA processing (GO:0031054)3.58624135
34nuclear envelope disassembly (GO:0051081)3.56458809
35membrane disassembly (GO:0030397)3.56458809
36exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.54481530
37nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.53766891
38synapsis (GO:0007129)3.52518771
39regulation of sister chromatid cohesion (GO:0007063)3.52510183
40DNA replication-independent nucleosome organization (GO:0034724)3.51990459
41DNA replication-independent nucleosome assembly (GO:0006336)3.51990459
42mitotic recombination (GO:0006312)3.50944914
43regulation of histone H3-K9 methylation (GO:0051570)3.49921116
44regulation of mitotic spindle organization (GO:0060236)3.47857290
45regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.47269478
46kinetochore assembly (GO:0051382)3.46923860
47lactate metabolic process (GO:0006089)3.46501912
48telomere maintenance via semi-conservative replication (GO:0032201)3.45771907
49regulation of translational fidelity (GO:0006450)3.45139833
50IMP biosynthetic process (GO:0006188)3.44534078
51negative regulation of histone methylation (GO:0031061)3.43713451
52proteasome assembly (GO:0043248)3.42979843
53nucleobase biosynthetic process (GO:0046112)3.40894087
54DNA catabolic process, exonucleolytic (GO:0000738)3.40755229
55regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.40663640
56signal peptide processing (GO:0006465)3.38348690
57postreplication repair (GO:0006301)3.35448688
58telomere maintenance via recombination (GO:0000722)3.34731585
59cytochrome complex assembly (GO:0017004)3.32080630
60establishment of chromosome localization (GO:0051303)3.28530616
61chromatin assembly or disassembly (GO:0006333)3.25421543
62attachment of spindle microtubules to kinetochore (GO:0008608)3.24100652
63regulation of hexokinase activity (GO:1903299)3.23340562
64regulation of glucokinase activity (GO:0033131)3.23340562
65mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.22001280
66positive regulation of chromosome segregation (GO:0051984)3.21625688
67DNA conformation change (GO:0071103)3.21233179
68negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.21199260
69recombinational repair (GO:0000725)3.20696276
70DNA ligation (GO:0006266)3.20349602
71double-strand break repair via homologous recombination (GO:0000724)3.18857934
72DNA topological change (GO:0006265)3.17475026
73protein K6-linked ubiquitination (GO:0085020)3.17361772
74pore complex assembly (GO:0046931)3.17276991
75non-recombinational repair (GO:0000726)3.13240147
76double-strand break repair via nonhomologous end joining (GO:0006303)3.13240147
77regulation of DNA endoreduplication (GO:0032875)3.11279531
78IMP metabolic process (GO:0046040)3.10846363
79peptidyl-histidine modification (GO:0018202)3.09792860
80histone exchange (GO:0043486)3.07254243
81tetrahydrofolate metabolic process (GO:0046653)3.06395664
82histone mRNA metabolic process (GO:0008334)3.06242105
83pteridine-containing compound biosynthetic process (GO:0042559)3.03250195
84chromatin assembly (GO:0031497)3.02086376
85protein localization to chromosome (GO:0034502)3.01219040
86regulation of helicase activity (GO:0051095)3.00243692
87meiotic chromosome segregation (GO:0045132)3.00137285
88DNA deamination (GO:0045006)2.98815486
89ribosome assembly (GO:0042255)2.98311788
90regulation of chromosome segregation (GO:0051983)2.97719829
91RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.97566596
92glycine metabolic process (GO:0006544)2.97026599
93regulation of mitochondrial translation (GO:0070129)2.95820919
94chromosome condensation (GO:0030261)2.95237151
95negative regulation of RNA splicing (GO:0033119)2.94629029
96negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.93844499
97spindle checkpoint (GO:0031577)2.92952849
98regulation of centrosome cycle (GO:0046605)2.92781418
99somatic diversification of immune receptors via somatic mutation (GO:0002566)2.91972168
100somatic hypermutation of immunoglobulin genes (GO:0016446)2.91972168
101response to X-ray (GO:0010165)2.91505773
102spindle assembly checkpoint (GO:0071173)2.89137214
103telomere maintenance via telomere lengthening (GO:0010833)2.88403211
104regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.88397647
105regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.88003376
106negative regulation of chromosome segregation (GO:0051985)2.87820639
107dosage compensation (GO:0007549)2.87371926
108regulation of posttranscriptional gene silencing (GO:0060147)2.86663173
109regulation of gene silencing by miRNA (GO:0060964)2.86663173
110regulation of gene silencing by RNA (GO:0060966)2.86663173
111nucleotide-excision repair, DNA gap filling (GO:0006297)2.85837039
112positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.84140698
113negative regulation of mRNA processing (GO:0050686)2.83995584
114heterochromatin organization (GO:0070828)2.83670290
115purine nucleobase biosynthetic process (GO:0009113)2.83619624
116chromosome segregation (GO:0007059)2.83484839
117ATP-dependent chromatin remodeling (GO:0043044)2.83431176
118negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.82549769
119negative regulation of sister chromatid segregation (GO:0033046)2.82549769
120negative regulation of mitotic sister chromatid separation (GO:2000816)2.82549769
121negative regulation of mitotic sister chromatid segregation (GO:0033048)2.82549769
122mitochondrial respiratory chain complex assembly (GO:0033108)2.82492561
123protein complex biogenesis (GO:0070271)2.82358831
124regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.82197016
125tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.81464888
126RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.81464888
127cellular ketone body metabolic process (GO:0046950)2.81368394
128ATP synthesis coupled proton transport (GO:0015986)2.80990527
129energy coupled proton transport, down electrochemical gradient (GO:0015985)2.80990527
130pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.80902108
131maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.80219741
132mitotic spindle assembly checkpoint (GO:0007094)2.79831686
133regulation of mitotic metaphase/anaphase transition (GO:0030071)2.79621524
134regulation of nuclear cell cycle DNA replication (GO:0033262)2.77211740
135regulation of acyl-CoA biosynthetic process (GO:0050812)2.77100857
136nuclear envelope organization (GO:0006998)2.77006723
137positive regulation of mitotic sister chromatid separation (GO:1901970)2.76634231
138positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.76634231
139positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.76634231
140mitotic spindle checkpoint (GO:0071174)2.76418430
141somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.76043336
142somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.76043336
143isotype switching (GO:0045190)2.76043336
144negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.75724438
145regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.74413957
146prenylation (GO:0097354)2.72368585
147protein prenylation (GO:0018342)2.72368585
148histone H2A monoubiquitination (GO:0035518)2.71514949
149centriole replication (GO:0007099)2.70704406
150rRNA modification (GO:0000154)2.70547045
151double-strand break repair (GO:0006302)2.70497392
152establishment of protein localization to mitochondrial membrane (GO:0090151)2.69864428
153establishment of integrated proviral latency (GO:0075713)2.69738676
154telomere maintenance (GO:0000723)2.68659062
155piRNA metabolic process (GO:0034587)2.68337072
156fucose catabolic process (GO:0019317)2.67854243
157L-fucose metabolic process (GO:0042354)2.67854243
158L-fucose catabolic process (GO:0042355)2.67854243
159DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.67691238
160mismatch repair (GO:0006298)2.67368115
161DNA-dependent DNA replication (GO:0006261)2.66909185
162resolution of meiotic recombination intermediates (GO:0000712)2.66791030
163translesion synthesis (GO:0019985)2.66668183
164negative regulation of ligase activity (GO:0051352)2.66116625
165negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.66116625
166intra-S DNA damage checkpoint (GO:0031573)2.65543140
167regulation of mitotic spindle checkpoint (GO:1903504)2.63432763
168regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.63432763
169dopamine transport (GO:0015872)2.63331265
170signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.63236056
171signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.63236056
172signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.63236056
173anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.62704085
174negative regulation of execution phase of apoptosis (GO:1900118)2.60570624
175DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.57987319
176protein neddylation (GO:0045116)2.56531151

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.80058645
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.57674550
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.06848422
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.57270954
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.50387396
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.89274135
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.85916169
8ZNF274_21170338_ChIP-Seq_K562_Hela2.66753795
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.60324516
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.53676535
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.47308580
12IGF1R_20145208_ChIP-Seq_DFB_Human2.44917828
13AR_21909140_ChIP-Seq_LNCAP_Human2.41094983
14EWS_26573619_Chip-Seq_HEK293_Human2.38254872
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.36206340
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.34357801
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20240531
18FUS_26573619_Chip-Seq_HEK293_Human2.19789399
19* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.17291867
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.09911214
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05664691
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.04798473
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.02766796
24* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00386222
25MYC_22102868_ChIP-Seq_BL_Human1.98738602
26VDR_22108803_ChIP-Seq_LS180_Human1.94057847
27XRN2_22483619_ChIP-Seq_HELA_Human1.94044409
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.92987583
29TAF15_26573619_Chip-Seq_HEK293_Human1.91267887
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85488884
31P300_19829295_ChIP-Seq_ESCs_Human1.79504028
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.78542481
33KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.78237336
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68912733
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68787291
36ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.68648858
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.68439540
38SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.67843527
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.66236536
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.65800703
41GBX2_23144817_ChIP-Seq_PC3_Human1.64497430
42CIITA_25753668_ChIP-Seq_RAJI_Human1.63622895
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.63170601
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62400115
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62148793
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.61525178
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60134637
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.58060923
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57229851
50FOXP3_21729870_ChIP-Seq_TREG_Human1.55012653
51VDR_23849224_ChIP-Seq_CD4+_Human1.54302451
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53604987
53ETS1_20019798_ChIP-Seq_JURKAT_Human1.52314753
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.51058943
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49372990
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.45339345
57ER_23166858_ChIP-Seq_MCF-7_Human1.44456085
58KDM5A_27292631_Chip-Seq_BREAST_Human1.44154009
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42376887
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40466932
61JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40278929
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39284310
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39057804
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.37624745
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37467668
66* ELK1_19687146_ChIP-ChIP_HELA_Human1.36880369
67TTF2_22483619_ChIP-Seq_HELA_Human1.36564760
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.36363761
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.35019275
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34052568
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.33935620
72BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33923371
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33226125
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.33048340
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.32124516
76ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31691212
77IRF1_19129219_ChIP-ChIP_H3396_Human1.31089193
78DCP1A_22483619_ChIP-Seq_HELA_Human1.30592845
79* GABP_19822575_ChIP-Seq_HepG2_Human1.30322046
80SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30048256
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28404058
82CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27248811
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26067290
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24834389
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24121715
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22760884
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22702215
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21647163
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20688774
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20602125
91EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19839620
92TP53_22573176_ChIP-Seq_HFKS_Human1.19108131
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17677841
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17614850
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17599516
96HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17502220
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17424374
98TP63_19390658_ChIP-ChIP_HaCaT_Human1.15884437
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.15375178
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13872947
101CBP_20019798_ChIP-Seq_JUKART_Human1.13872947
102* STAT3_23295773_ChIP-Seq_U87_Human1.12373609
103FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12253984
104SOX2_19829295_ChIP-Seq_ESCs_Human1.11989692
105NANOG_19829295_ChIP-Seq_ESCs_Human1.11989692
106SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11262372
107SMAD4_21799915_ChIP-Seq_A2780_Human1.10416482
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09748404
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09667853
110MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09487329
111PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09400299
112ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08797667
113E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08782196
114ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08674370
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08661703
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08307489
117P53_22387025_ChIP-Seq_ESCs_Mouse1.08294396
118* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07397796
119POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06786509
120SMAD3_21741376_ChIP-Seq_EPCs_Human1.06502211
121PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06355145
122P300_18555785_Chip-Seq_ESCs_Mouse1.06116021
123BCAT_22108803_ChIP-Seq_LS180_Human1.05668206
124CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05309917
125E2F1_18555785_Chip-Seq_ESCs_Mouse1.05158419
126NANOG_21062744_ChIP-ChIP_HESCs_Human1.04604456
127SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04138373
128PIAS1_25552417_ChIP-Seq_VCAP_Human1.04027861
129SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03871222
130RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03667932
131NANOG_16153702_ChIP-ChIP_HESCs_Human1.02716585
132TCF4_22108803_ChIP-Seq_LS180_Human1.02208660
133CRX_20693478_ChIP-Seq_RETINA_Mouse1.02112166
134STAT3_18555785_Chip-Seq_ESCs_Mouse1.02076071
135FOXA1_25329375_ChIP-Seq_VCAP_Human1.01844116
136FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01844116
137CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01503352
138ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01389518
139AR_25329375_ChIP-Seq_VCAP_Human1.01226890
140CMYC_18555785_Chip-Seq_ESCs_Mouse1.00929148
141SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00384130
142THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00328365
143RXR_22158963_ChIP-Seq_LIVER_Mouse1.00318758
144* TFEB_21752829_ChIP-Seq_HELA_Human0.99929010
145SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99051603
146KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98785017
147KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98785017
148KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98785017
149TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98476294
150VDR_21846776_ChIP-Seq_THP-1_Human0.98446965
151DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97722680
152OCT4_18555785_Chip-Seq_ESCs_Mouse0.96668487
153* TCF4_23295773_ChIP-Seq_U87_Human0.95912605
154EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.94361792
155CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93765843
156FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93509355
157HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93495003
158STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92631482
159KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91413444
160CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89695888
161GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89495382
162SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89364512
163TCF3_18692474_ChIP-Seq_MESCs_Mouse0.88611568
164KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87730145
165PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.86432894
166SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85953864
167BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84651810
168E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.84070308
169CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82789076
170MYC_18940864_ChIP-ChIP_HL60_Human0.82573514
171MYB_26560356_Chip-Seq_TH1_Human0.81574309

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.06978096
2MP0010094_abnormal_chromosome_stability4.02268433
3MP0003111_abnormal_nucleus_morphology3.65335278
4MP0004957_abnormal_blastocyst_morpholog3.34293124
5MP0003077_abnormal_cell_cycle3.23970183
6MP0008057_abnormal_DNA_replication2.89473978
7MP0006072_abnormal_retinal_apoptosis2.59925210
8MP0003806_abnormal_nucleotide_metabolis2.55120068
9MP0008058_abnormal_DNA_repair2.35409924
10MP0006292_abnormal_olfactory_placode2.26805837
11MP0005379_endocrine/exocrine_gland_phen2.23410664
12MP0008007_abnormal_cellular_replicative2.23269480
13MP0002139_abnormal_hepatobiliary_system2.22858865
14MP0010307_abnormal_tumor_latency2.19497599
15MP0003787_abnormal_imprinting2.18116512
16MP0001730_embryonic_growth_arrest2.16652238
17MP0002163_abnormal_gland_morphology2.16466040
18MP0002837_dystrophic_cardiac_calcinosis2.10071395
19MP0010352_gastrointestinal_tract_polyps2.09074200
20MP0002102_abnormal_ear_morphology2.08365553
21MP0003705_abnormal_hypodermis_morpholog2.02604830
22MP0002396_abnormal_hematopoietic_system2.00509828
23MP0005645_abnormal_hypothalamus_physiol1.99729528
24MP0000350_abnormal_cell_proliferation1.95612830
25MP0004147_increased_porphyrin_level1.94490926
26MP0009053_abnormal_anal_canal1.93074359
27MP0008932_abnormal_embryonic_tissue1.89710436
28MP0000372_irregular_coat_pigmentation1.88429397
29MP0005365_abnormal_bile_salt1.76165691
30MP0005360_urolithiasis1.75627311
31MP0003890_abnormal_embryonic-extraembry1.74970673
32MP0003941_abnormal_skin_development1.73438269
33MP0005076_abnormal_cell_differentiation1.72768575
34MP0001984_abnormal_olfaction1.70873335
35MP0001672_abnormal_embryogenesis/_devel1.66999127
36MP0005380_embryogenesis_phenotype1.66999127
37MP0001697_abnormal_embryo_size1.66853798
38MP0000537_abnormal_urethra_morphology1.65894699
39MP0000427_abnormal_hair_cycle1.64249191
40MP0004197_abnormal_fetal_growth/weight/1.60773290
41MP0003195_calcinosis1.59859771
42MP0005085_abnormal_gallbladder_physiolo1.56290283
43MP0002084_abnormal_developmental_patter1.55663641
44MP0005084_abnormal_gallbladder_morpholo1.52988226
45MP0002085_abnormal_embryonic_tissue1.52364958
46MP0002086_abnormal_extraembryonic_tissu1.52151496
47MP0003984_embryonic_growth_retardation1.46253883
48MP0008877_abnormal_DNA_methylation1.45057516
49MP0002088_abnormal_embryonic_growth/wei1.44851638
50MP0001529_abnormal_vocalization1.44249085
51MP0001986_abnormal_taste_sensitivity1.43755788
52MP0005253_abnormal_eye_physiology1.43344603
53MP0002080_prenatal_lethality1.43051525
54MP0000516_abnormal_urinary_system1.39423607
55MP0005367_renal/urinary_system_phenotyp1.39423607
56MP0000566_synostosis1.39288152
57MP0002254_reproductive_system_inflammat1.35924842
58MP0005187_abnormal_penis_morphology1.35415493
59MP0005075_abnormal_melanosome_morpholog1.33405248
60MP0002160_abnormal_reproductive_system1.32077737
61MP0000490_abnormal_crypts_of1.32022215
62MP0005551_abnormal_eye_electrophysiolog1.30944438
63MP0003119_abnormal_digestive_system1.30089619
64MP0002019_abnormal_tumor_incidence1.29813732
65MP0005646_abnormal_pituitary_gland1.27570097
66MP0005389_reproductive_system_phenotype1.26902424
67MP0002736_abnormal_nociception_after1.26132662
68MP0002909_abnormal_adrenal_gland1.26074255
69MP0009672_abnormal_birth_weight1.24224145
70MP0002095_abnormal_skin_pigmentation1.23929006
71MP0009697_abnormal_copulation1.23059656
72MP0003123_paternal_imprinting1.20731617
73MP0003718_maternal_effect1.20410356
74MP0003121_genomic_imprinting1.19368861
75MP0004808_abnormal_hematopoietic_stem1.18843655
76MP0000569_abnormal_digit_pigmentation1.16121189
77MP0000313_abnormal_cell_death1.15711804
78MP0002166_altered_tumor_susceptibility1.15654004
79MP0000015_abnormal_ear_pigmentation1.15055829
80MP0008995_early_reproductive_senescence1.14750814
81MP0009379_abnormal_foot_pigmentation1.14511779
82MP0006036_abnormal_mitochondrial_physio1.11342992
83MP0003567_abnormal_fetal_cardiomyocyte1.09807773
84MP0005174_abnormal_tail_pigmentation1.09487699
85MP0006054_spinal_hemorrhage1.09071711
86MP0004185_abnormal_adipocyte_glucose1.08481570
87MP0009703_decreased_birth_body1.07881929
88MP0002877_abnormal_melanocyte_morpholog1.06895824
89MP0001293_anophthalmia1.06720084
90MP0002693_abnormal_pancreas_physiology1.06400091
91MP0006035_abnormal_mitochondrial_morpho1.05472814
92MP0000631_abnormal_neuroendocrine_gland1.04440359
93MP0004264_abnormal_extraembryonic_tissu1.03319405
94MP0003186_abnormal_redox_activity1.02204949
95MP0005248_abnormal_Harderian_gland1.01245019
96MP0001919_abnormal_reproductive_system1.00948950
97MP0003937_abnormal_limbs/digits/tail_de1.00729355
98MP0008872_abnormal_physiological_respon0.99572872
99MP0000703_abnormal_thymus_morphology0.99258064
100MP0001915_intracranial_hemorrhage0.98902829
101MP0005220_abnormal_exocrine_pancreas0.97416269
102MP0002928_abnormal_bile_duct0.97232418
103MP0003122_maternal_imprinting0.95969487
104MP0001944_abnormal_pancreas_morphology0.95709214
105MP0002006_tumorigenesis0.93306141
106MP0000647_abnormal_sebaceous_gland0.92760121
107MP0005023_abnormal_wound_healing0.92372658
108MP0003786_premature_aging0.91935475
109MP0000371_diluted_coat_color0.90403782
110MP0000598_abnormal_liver_morphology0.88851904
111MP0003950_abnormal_plasma_membrane0.87716339
112MP0002722_abnormal_immune_system0.87714799
113MP0002111_abnormal_tail_morphology0.87350505
114MP0005408_hypopigmentation0.86747306
115MP0004142_abnormal_muscle_tone0.85980079
116MP0000689_abnormal_spleen_morphology0.85224593
117MP0005332_abnormal_amino_acid0.84099763
118MP0003698_abnormal_male_reproductive0.84076489
119MP0010386_abnormal_urinary_bladder0.84016626
120MP0002398_abnormal_bone_marrow0.83918872
121MP0002938_white_spotting0.82032801
122MP0005397_hematopoietic_system_phenotyp0.81949302
123MP0001545_abnormal_hematopoietic_system0.81949302
124MP0000609_abnormal_liver_physiology0.81450307
125MP0003763_abnormal_thymus_physiology0.80929296
126MP0003252_abnormal_bile_duct0.80613019
127MP0003566_abnormal_cell_adhesion0.79983039
128MP0001968_abnormal_touch/_nociception0.79816890
129MP0000538_abnormal_urinary_bladder0.78638981
130MP0002697_abnormal_eye_size0.78213261
131MP0009046_muscle_twitch0.77876408
132MP0009278_abnormal_bone_marrow0.77219002
133MP0001485_abnormal_pinna_reflex0.76774498
134MP0002210_abnormal_sex_determination0.76557012
135MP0003453_abnormal_keratinocyte_physiol0.76467312
136MP0001145_abnormal_male_reproductive0.76467092
137MP0002751_abnormal_autonomic_nervous0.76179317
138MP0010030_abnormal_orbit_morphology0.76076702
139MP0004215_abnormal_myocardial_fiber0.76018460
140MP0001119_abnormal_female_reproductive0.75834001
141MP0000733_abnormal_muscle_development0.75665665
142MP0000477_abnormal_intestine_morphology0.74076731
143MP0005636_abnormal_mineral_homeostasis0.72984251
144MP0001661_extended_life_span0.72816825
145MP0002092_abnormal_eye_morphology0.72575136
146MP0002638_abnormal_pupillary_reflex0.72244954
147MP0000462_abnormal_digestive_system0.71920586
148MP0000013_abnormal_adipose_tissue0.71706349
149MP0009333_abnormal_splenocyte_physiolog0.71603949
150MP0001324_abnormal_eye_pigmentation0.71238201
151MP0002075_abnormal_coat/hair_pigmentati0.71203654
152MP0000653_abnormal_sex_gland0.69718210
153MP0003943_abnormal_hepatobiliary_system0.68869867
154MP0010329_abnormal_lipoprotein_level0.68785444
155MP0003136_yellow_coat_color0.68184798
156MP0000467_abnormal_esophagus_morphology0.67883365
157MP0005391_vision/eye_phenotype0.67306575
158MP0004133_heterotaxia0.67225141
159MP0000358_abnormal_cell_content/0.66913164
160MP0001929_abnormal_gametogenesis0.65610588
161MP0002429_abnormal_blood_cell0.64090425
162MP0005621_abnormal_cell_physiology0.63785467
163MP0000858_altered_metastatic_potential0.61786765
164MP0003699_abnormal_female_reproductive0.61247099
165MP0005384_cellular_phenotype0.60765808

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.19357592
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.96186316
3Ependymoma (HP:0002888)3.91366389
4Medulloblastoma (HP:0002885)3.65832246
5Abnormality of pyrimidine metabolism (HP:0004353)3.59411835
6Hypobetalipoproteinemia (HP:0003563)3.30609088
7Volvulus (HP:0002580)3.29086412
8Abnormality of chromosome stability (HP:0003220)3.25125667
9Pancreatic cysts (HP:0001737)3.15064541
10Reticulocytopenia (HP:0001896)3.09349436
11Abnormality of the renal cortex (HP:0011035)3.06937980
12Renal cortical cysts (HP:0000803)3.05486518
13Rhabdomyosarcoma (HP:0002859)2.96925968
14Abnormality of monocarboxylic acid metabolism (HP:0010996)2.94913859
15Hypothermia (HP:0002045)2.92514730
16Pancreatic fibrosis (HP:0100732)2.87749543
17Progressive macrocephaly (HP:0004481)2.85841635
18Acute necrotizing encephalopathy (HP:0006965)2.84012658
19Deep venous thrombosis (HP:0002625)2.83404141
20Methylmalonic acidemia (HP:0002912)2.83315716
21Birth length less than 3rd percentile (HP:0003561)2.83310716
22Colon cancer (HP:0003003)2.76970160
23True hermaphroditism (HP:0010459)2.76876296
24Neoplasm of the oral cavity (HP:0100649)2.73976583
25Acute encephalopathy (HP:0006846)2.72811701
26Abnormality of midbrain morphology (HP:0002418)2.72000691
27Molar tooth sign on MRI (HP:0002419)2.72000691
28Selective tooth agenesis (HP:0001592)2.71153781
29Abnormality of the astrocytes (HP:0100707)2.71114458
30Astrocytoma (HP:0009592)2.71114458
31Neoplasm of the adrenal cortex (HP:0100641)2.70700270
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.69991964
33Ectopic kidney (HP:0000086)2.68335224
34Nephronophthisis (HP:0000090)2.66286551
35Increased hepatocellular lipid droplets (HP:0006565)2.66271072
36Hypochromic microcytic anemia (HP:0004840)2.66259442
37Abnormality of alanine metabolism (HP:0010916)2.62769081
38Hyperalaninemia (HP:0003348)2.62769081
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.62769081
40Intrahepatic cholestasis (HP:0001406)2.59333552
41Abnormality of the ileum (HP:0001549)2.57210304
42Lipid accumulation in hepatocytes (HP:0006561)2.56887873
43Increased CSF lactate (HP:0002490)2.54596601
44Basal cell carcinoma (HP:0002671)2.53029354
45Aplastic anemia (HP:0001915)2.51103727
46Oligodactyly (hands) (HP:0001180)2.48782646
47Neoplasm of the adrenal gland (HP:0100631)2.48014495
48Abnormality of the labia minora (HP:0012880)2.47491148
49Glioma (HP:0009733)2.44640795
50Impulsivity (HP:0100710)2.43765403
51Meckel diverticulum (HP:0002245)2.43682707
52Myelodysplasia (HP:0002863)2.41631949
53Mitochondrial inheritance (HP:0001427)2.41280584
54Neoplasm of striated muscle (HP:0009728)2.40909808
553-Methylglutaconic aciduria (HP:0003535)2.40455795
56Abnormality of the renal medulla (HP:0100957)2.40447517
57Lip pit (HP:0100267)2.39696760
58Duodenal stenosis (HP:0100867)2.39544526
59Small intestinal stenosis (HP:0012848)2.39544526
60Proximal placement of thumb (HP:0009623)2.38587108
61Abnormality of the duodenum (HP:0002246)2.35419696
62Deviation of the thumb (HP:0009603)2.34994325
63Hyperglycinemia (HP:0002154)2.33448798
64Abnormality of the preputium (HP:0100587)2.32770156
65Abnormality of aspartate family amino acid metabolism (HP:0010899)2.32576587
66Medial flaring of the eyebrow (HP:0010747)2.32405340
67Abnormality of vitamin B metabolism (HP:0004340)2.29714900
68Agnosia (HP:0010524)2.28225495
69Hypoplastic labia majora (HP:0000059)2.28101884
70Spastic diplegia (HP:0001264)2.26533381
71Abnormality of serum amino acid levels (HP:0003112)2.25260068
72Prominent nose (HP:0000448)2.22740407
73Facial hemangioma (HP:0000329)2.21733478
74Methylmalonic aciduria (HP:0012120)2.19478166
75Chronic hepatic failure (HP:0100626)2.17920866
76Oral leukoplakia (HP:0002745)2.17384936
77Gastrointestinal carcinoma (HP:0002672)2.17341852
78Malignant gastrointestinal tract tumors (HP:0006749)2.17341852
79Absent radius (HP:0003974)2.17051901
80Abnormality of the salivary glands (HP:0010286)2.16726835
81Tubulointerstitial nephritis (HP:0001970)2.16341290
82Cafe-au-lait spot (HP:0000957)2.16307165
83Abnormal mitochondria in muscle tissue (HP:0008316)2.16072211
84Patellar aplasia (HP:0006443)2.15186557
85Abnormality of aromatic amino acid family metabolism (HP:0004338)2.14913668
86Increased nuchal translucency (HP:0010880)2.14187054
87Tubular atrophy (HP:0000092)2.12453763
88Thyroiditis (HP:0100646)2.11856922
89Biliary tract neoplasm (HP:0100574)2.11469132
90Fair hair (HP:0002286)2.09207330
91Short 4th metacarpal (HP:0010044)2.08585456
92Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.08585456
93Acute lymphatic leukemia (HP:0006721)2.06765532
94Hypoplasia of the fovea (HP:0007750)2.06168888
95Aplasia/Hypoplasia of the fovea (HP:0008060)2.06168888
96Breast hypoplasia (HP:0003187)2.04967782
97Intestinal atresia (HP:0011100)2.04800832
98Gaze-evoked nystagmus (HP:0000640)2.02200823
99Abnormality of the labia majora (HP:0012881)2.01853330
10011 pairs of ribs (HP:0000878)2.01150162
101Abolished electroretinogram (ERG) (HP:0000550)2.01025310
102Cerebral edema (HP:0002181)2.00772202
103Abnormal number of incisors (HP:0011064)2.00734383
104Amaurosis fugax (HP:0100576)2.00373738
105Abnormality of B cell number (HP:0010975)1.99457040
106Clubbing of toes (HP:0100760)1.99327016
107Hypoglycemic coma (HP:0001325)1.98433680
108Supernumerary spleens (HP:0009799)1.97268054
109Increased serum lactate (HP:0002151)1.97009600
110Abnormality of the alveolar ridges (HP:0006477)1.96888387
111Sloping forehead (HP:0000340)1.96667886
112B lymphocytopenia (HP:0010976)1.95956607
113Abnormal biliary tract physiology (HP:0012439)1.94423349
114Bile duct proliferation (HP:0001408)1.94423349
115Aplasia involving forearm bones (HP:0009822)1.93860889
116Absent forearm bone (HP:0003953)1.93860889
117Aplasia/Hypoplasia of the tongue (HP:0010295)1.92871545
118Furrowed tongue (HP:0000221)1.92668467
119Abnormality of sulfur amino acid metabolism (HP:0004339)1.91597668
120Aplasia/Hypoplasia of the patella (HP:0006498)1.91260157
121Missing ribs (HP:0000921)1.89338883
122Attenuation of retinal blood vessels (HP:0007843)1.88500543
123Hyperinsulinemic hypoglycemia (HP:0000825)1.86481210
124Hypoglycemic seizures (HP:0002173)1.86251086
125Aqueductal stenosis (HP:0002410)1.85640020
126Poikilocytosis (HP:0004447)1.85362860
127Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.85266358
128Abnormality of reticulocytes (HP:0004312)1.84997684
129Hypolipoproteinemia (HP:0010981)1.84525104
130Rib fusion (HP:0000902)1.84192421
131Thyroid carcinoma (HP:0002890)1.83648583
132Arteriovenous malformation (HP:0100026)1.83597992
133Abnormal rod and cone electroretinograms (HP:0008323)1.83331879
134Skull defect (HP:0001362)1.83278654
135Abnormal lung lobation (HP:0002101)1.82859469
136Long eyelashes (HP:0000527)1.82832544
137Polygenic inheritance (HP:0010982)1.82554936
138Acanthocytosis (HP:0001927)1.82544907
139Hypoproteinemia (HP:0003075)1.81840732
140Abnormality of the fovea (HP:0000493)1.81193912
141Abnormality of the carotid arteries (HP:0005344)1.81112567
142Squamous cell carcinoma (HP:0002860)1.79063428
143Horseshoe kidney (HP:0000085)1.79056765
144Short thumb (HP:0009778)1.78430779
145Nephroblastoma (Wilms tumor) (HP:0002667)1.78137281
146Gastrointestinal atresia (HP:0002589)1.76919390
147Abnormality of methionine metabolism (HP:0010901)1.76325158
148Neoplasm of the pancreas (HP:0002894)1.76210031
149Poor head control (HP:0002421)1.75746270
150Hypoalbuminemia (HP:0003073)1.74793120
151Abnormal albumin level (HP:0012116)1.74793120
152Esophageal atresia (HP:0002032)1.74741617
153Pancreatic islet-cell hyperplasia (HP:0004510)1.74044234
154Deep philtrum (HP:0002002)1.73332388
155Pseudobulbar signs (HP:0002200)1.72731719
156Sandal gap (HP:0001852)1.72341274
157Hepatic necrosis (HP:0002605)1.71772933
158Neoplasm of the colon (HP:0100273)1.71710067
159Abnormality of the fingertips (HP:0001211)1.71668851
160Absent thumb (HP:0009777)1.71090368
161Abnormal biliary tract morphology (HP:0012440)1.70917487
162Lethargy (HP:0001254)1.70834009
163Increased mean platelet volume (HP:0011877)1.70787074
164Papillary thyroid carcinoma (HP:0002895)1.70345021
165Stomach cancer (HP:0012126)1.69210680
166Cortical dysplasia (HP:0002539)1.69176064
167Hepatocellular necrosis (HP:0001404)1.69139848
168Congenital primary aphakia (HP:0007707)1.69075631
169Abnormal platelet volume (HP:0011876)1.67925617
170Abnormality of the vitamin B12 metabolism (HP:0004341)1.67685703
171Sclerocornea (HP:0000647)1.67593615
172Hypomagnesemia (HP:0002917)1.66550252
173Progressive inability to walk (HP:0002505)1.65186430
174Oligodactyly (HP:0012165)1.64169409
175Congenital malformation of the right heart (HP:0011723)1.62500649
176Double outlet right ventricle (HP:0001719)1.62500649
177Nephrogenic diabetes insipidus (HP:0009806)1.61879883
178Optic disc pallor (HP:0000543)1.61843520

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.84303391
2CDC74.15808340
3WEE13.34155337
4MST43.09644754
5SRPK13.03397600
6EEF2K3.02449709
7CDK122.68862700
8TNIK2.54090971
9TTK2.46343402
10WNK32.42400609
11NEK22.42114298
12BUB12.35161696
13PKN22.34631242
14BMPR1B2.34414571
15NUAK12.34017042
16PASK2.21023589
17FLT32.05150504
18MAP3K101.98406105
19NEK11.98182776
20BRD41.88150454
21MAP4K21.84112832
22CDK41.78186265
23STK38L1.77789827
24RPS6KB21.72784033
25TSSK61.72322016
26ATR1.71280830
27ERBB31.69901553
28PLK11.69726215
29BRSK21.63120551
30AURKB1.59400912
31VRK21.58496882
32STK101.54964948
33STK41.53209292
34PLK21.46666426
35TRIB31.45501547
36CDK61.45422563
37MAP3K121.44759435
38MAP3K81.41461583
39CDK71.40810066
40EIF2AK11.38082363
41TAOK31.37195540
42CHEK21.34885499
43TRIM281.33253799
44MELK1.32897722
45CASK1.31925740
46MAP3K41.30902036
47MKNK11.30773812
48TLK11.27836554
49CCNB11.25243462
50CHEK11.24962448
51ACVR1B1.23080193
52STK161.22522540
53TIE11.21536752
54GRK11.21292930
55MKNK21.17846966
56TGFBR11.16301852
57DYRK31.15742445
58INSRR1.15269523
59WNK41.12399739
60BCR1.11683354
61SIK11.08322290
62PIM11.08307670
63TAF11.07820136
64PNCK1.07101574
65NLK1.06637676
66RPS6KA41.06564126
67PLK31.05604972
68CAMK1D1.05408982
69MTOR1.05104408
70CSNK1G21.04995025
71ATM1.04719012
72ADRBK21.03804079
73LATS11.02894384
74STK31.02145703
75BCKDK1.02002379
76TESK20.96474439
77PLK40.96111082
78VRK10.94707312
79AURKA0.91001080
80ALK0.90394213
81LRRK20.90174672
82YES10.89188529
83EPHA20.88156773
84NEK90.87227897
85TEC0.86544459
86CDK20.86358078
87BRSK10.85319726
88FGFR40.84497044
89STK390.81656381
90PRKCE0.79873845
91MAPKAPK30.75894270
92PINK10.73400974
93ZAK0.73032835
94STK240.71611548
95PAK40.70834620
96CSF1R0.70419355
97MAP4K10.70037233
98FGFR10.68455280
99CDK10.66690151
100BMPR20.66206498
101CDK80.65733679
102CDK90.64684448
103OXSR10.64149888
104NME10.60041821
105TRPM70.59104805
106GRK60.58926128
107PDGFRA0.58015230
108SCYL20.57315380
109PTK60.55610824
110MARK30.55491190
111ICK0.55075208
112EIF2AK30.55034261
113PBK0.53478687
114PAK30.53392075
115MAPK110.52419880
116CLK10.51631718
117CSNK1D0.51062094
118CDK30.50834749
119MAPK130.50791152
120EIF2AK20.47472320
121CSNK2A20.46885631
122ERBB20.46503710
123FER0.44595555
124ERN10.44345399
125NME20.43877281
126BMX0.43504903
127TXK0.43485272
128PAK20.43302551
129TTN0.41188645
130CSNK2A10.40872887
131FGFR20.40146257
132CHUK0.39588328
133PRKDC0.39274388
134CSNK1A1L0.38975140
135KIT0.37167720
136CSNK1G10.36847188
137TYK20.35351630
138RPS6KA50.35157444
139PTK2B0.33982288
140CSNK1E0.33560868
141JAK30.33517602
142CSNK1G30.33383126
143CSNK1A10.33325238
144ADRBK10.33250652
145PRKCI0.32947005
146ERBB40.32796759
147PRKACB0.32555445
148MAPK140.32488876
149MAPK10.32220033
150ITK0.27189025
151PRKG10.26153345
152IRAK10.25757873
153CAMKK20.25634172
154DYRK20.24535979
155PHKG20.22509418

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.01832726
2Mismatch repair_Homo sapiens_hsa034303.73979287
3Protein export_Homo sapiens_hsa030603.44084658
4One carbon pool by folate_Homo sapiens_hsa006703.09127609
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.79910865
6Cell cycle_Homo sapiens_hsa041102.67593656
7Spliceosome_Homo sapiens_hsa030402.56348577
8Oxidative phosphorylation_Homo sapiens_hsa001902.46216081
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.45874280
10RNA transport_Homo sapiens_hsa030132.39782703
11Propanoate metabolism_Homo sapiens_hsa006402.29089949
12Nucleotide excision repair_Homo sapiens_hsa034202.25612132
13Base excision repair_Homo sapiens_hsa034102.23289971
14Non-homologous end-joining_Homo sapiens_hsa034502.20792395
15Homologous recombination_Homo sapiens_hsa034402.20576633
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.16945105
17Selenocompound metabolism_Homo sapiens_hsa004502.09350837
18Systemic lupus erythematosus_Homo sapiens_hsa053222.04454458
19Fanconi anemia pathway_Homo sapiens_hsa034601.95792905
20Parkinsons disease_Homo sapiens_hsa050121.93990648
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91995317
22Butanoate metabolism_Homo sapiens_hsa006501.87879649
23p53 signaling pathway_Homo sapiens_hsa041151.61080694
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.55978000
25RNA degradation_Homo sapiens_hsa030181.55803387
26Ribosome_Homo sapiens_hsa030101.54866790
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.54687863
28mRNA surveillance pathway_Homo sapiens_hsa030151.52324288
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50644724
30Pyrimidine metabolism_Homo sapiens_hsa002401.49357561
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.46884905
32Huntingtons disease_Homo sapiens_hsa050161.35664496
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.32669068
34Folate biosynthesis_Homo sapiens_hsa007901.32667038
35Lysine degradation_Homo sapiens_hsa003101.32511446
36RNA polymerase_Homo sapiens_hsa030201.26131975
37Viral carcinogenesis_Homo sapiens_hsa052031.25828155
38Biosynthesis of amino acids_Homo sapiens_hsa012301.23752412
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.20574428
40Basal transcription factors_Homo sapiens_hsa030221.19801488
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11371785
42Alzheimers disease_Homo sapiens_hsa050101.10474487
43Peroxisome_Homo sapiens_hsa041461.10448473
44Sulfur metabolism_Homo sapiens_hsa009201.06866539
45Pyruvate metabolism_Homo sapiens_hsa006201.06110625
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01424037
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.01019981
48Nitrogen metabolism_Homo sapiens_hsa009101.00267811
49Fatty acid elongation_Homo sapiens_hsa000620.99544090
50Type I diabetes mellitus_Homo sapiens_hsa049400.99281561
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.95931775
52Steroid biosynthesis_Homo sapiens_hsa001000.94524663
53Sulfur relay system_Homo sapiens_hsa041220.93386922
54Arginine biosynthesis_Homo sapiens_hsa002200.92810440
55Complement and coagulation cascades_Homo sapiens_hsa046100.92145402
56MicroRNAs in cancer_Homo sapiens_hsa052060.91379925
57Small cell lung cancer_Homo sapiens_hsa052220.90337213
58Phototransduction_Homo sapiens_hsa047440.89891444
59Asthma_Homo sapiens_hsa053100.89239307
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88766870
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88345579
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87107799
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85092077
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83217300
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.82538317
66Herpes simplex infection_Homo sapiens_hsa051680.82262293
67Antigen processing and presentation_Homo sapiens_hsa046120.80321627
68Collecting duct acid secretion_Homo sapiens_hsa049660.78523439
69HTLV-I infection_Homo sapiens_hsa051660.78262753
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77067926
71Epstein-Barr virus infection_Homo sapiens_hsa051690.77020506
72Tryptophan metabolism_Homo sapiens_hsa003800.76832066
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76124227
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75962142
75Caffeine metabolism_Homo sapiens_hsa002320.75295158
76Pentose phosphate pathway_Homo sapiens_hsa000300.74454439
77Ether lipid metabolism_Homo sapiens_hsa005650.73603953
78Metabolic pathways_Homo sapiens_hsa011000.72866562
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69756664
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68106096
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67453395
82Oocyte meiosis_Homo sapiens_hsa041140.64906513
83Thyroid cancer_Homo sapiens_hsa052160.63688075
84Colorectal cancer_Homo sapiens_hsa052100.63418554
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63267773
86Notch signaling pathway_Homo sapiens_hsa043300.62382539
87Carbon metabolism_Homo sapiens_hsa012000.60833512
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59594502
89Basal cell carcinoma_Homo sapiens_hsa052170.58431364
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58347829
91mTOR signaling pathway_Homo sapiens_hsa041500.57994012
92Regulation of autophagy_Homo sapiens_hsa041400.57567322
93Chronic myeloid leukemia_Homo sapiens_hsa052200.55416645
94Proteasome_Homo sapiens_hsa030500.54724738
95Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54473950
96Fatty acid degradation_Homo sapiens_hsa000710.54428885
97Purine metabolism_Homo sapiens_hsa002300.54248347
98Cardiac muscle contraction_Homo sapiens_hsa042600.53295645
99Alcoholism_Homo sapiens_hsa050340.51478920
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51376052
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.49522357
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48790521
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47528006
104Linoleic acid metabolism_Homo sapiens_hsa005910.46751412
105Adherens junction_Homo sapiens_hsa045200.44570589
106Acute myeloid leukemia_Homo sapiens_hsa052210.44354631
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44039907
108Retinol metabolism_Homo sapiens_hsa008300.44020919
109TGF-beta signaling pathway_Homo sapiens_hsa043500.43940844
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42615766
111Primary immunodeficiency_Homo sapiens_hsa053400.42455721
112N-Glycan biosynthesis_Homo sapiens_hsa005100.42322381
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41810183
114Graft-versus-host disease_Homo sapiens_hsa053320.41695286
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.41568781
116Autoimmune thyroid disease_Homo sapiens_hsa053200.41168960
117Hippo signaling pathway_Homo sapiens_hsa043900.40898800
118Olfactory transduction_Homo sapiens_hsa047400.40840209
119PPAR signaling pathway_Homo sapiens_hsa033200.40707374
120Vitamin B6 metabolism_Homo sapiens_hsa007500.40637970
121beta-Alanine metabolism_Homo sapiens_hsa004100.40374383
122Chemical carcinogenesis_Homo sapiens_hsa052040.40331826
123Hepatitis B_Homo sapiens_hsa051610.39564167
124Apoptosis_Homo sapiens_hsa042100.39404899
125Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38335484
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37766076
127Non-small cell lung cancer_Homo sapiens_hsa052230.37644353
128Prostate cancer_Homo sapiens_hsa052150.36002876
129Bladder cancer_Homo sapiens_hsa052190.35997674
130NF-kappa B signaling pathway_Homo sapiens_hsa040640.34913576
131AMPK signaling pathway_Homo sapiens_hsa041520.34624563
132Fat digestion and absorption_Homo sapiens_hsa049750.34594369
133Allograft rejection_Homo sapiens_hsa053300.34048723
134ABC transporters_Homo sapiens_hsa020100.32614062
135Sphingolipid metabolism_Homo sapiens_hsa006000.32386508
136Legionellosis_Homo sapiens_hsa051340.31565256
137Pancreatic cancer_Homo sapiens_hsa052120.30621166
138Fatty acid metabolism_Homo sapiens_hsa012120.29723902
139Circadian rhythm_Homo sapiens_hsa047100.29692014
140Steroid hormone biosynthesis_Homo sapiens_hsa001400.29342964
141SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28792844
142Glutathione metabolism_Homo sapiens_hsa004800.28432282
143alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28259344
144Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26828787

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