SRC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)5.48387201
2establishment of apical/basal cell polarity (GO:0035089)5.32521857
3proline biosynthetic process (GO:0006561)5.13987557
4regulation of vitamin metabolic process (GO:0030656)4.94886122
5establishment or maintenance of monopolar cell polarity (GO:0061339)4.79168522
6establishment of monopolar cell polarity (GO:0061162)4.79168522
7response to peptidoglycan (GO:0032494)4.48537769
8regulation of cytokine secretion involved in immune response (GO:0002739)4.36074694
9negative regulation of interleukin-12 production (GO:0032695)4.35264150
10embryonic process involved in female pregnancy (GO:0060136)4.33990799
11lipopolysaccharide-mediated signaling pathway (GO:0031663)4.24030715
12positive regulation of membrane protein ectodomain proteolysis (GO:0051044)4.21998062
13regulation of fever generation (GO:0031620)4.16879891
14positive regulation of chemokine biosynthetic process (GO:0045080)4.16595226
15positive regulation of heat generation (GO:0031652)4.15423980
16regulation of mononuclear cell migration (GO:0071675)4.09645904
17layer formation in cerebral cortex (GO:0021819)3.90003153
18cytoskeletal anchoring at plasma membrane (GO:0007016)3.88418845
19NIK/NF-kappaB signaling (GO:0038061)3.82214734
20cell migration in hindbrain (GO:0021535)3.81030534
21glycosphingolipid catabolic process (GO:0046479)3.78291787
22T-helper 1 type immune response (GO:0042088)3.74201416
23regulation of hippo signaling (GO:0035330)3.69633795
24locomotory exploration behavior (GO:0035641)3.67154274
25regulation of membrane protein ectodomain proteolysis (GO:0051043)3.66794898
26negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.64667962
27regulation of chemokine biosynthetic process (GO:0045073)3.59952110
28polarized epithelial cell differentiation (GO:0030859)3.58035275
29activation of Rac GTPase activity (GO:0032863)3.56619103
30protein localization to endosome (GO:0036010)3.46229180
31oligosaccharide catabolic process (GO:0009313)3.44028980
32positive regulation of protein homooligomerization (GO:0032464)3.42909876
33regulation of T-helper 1 cell differentiation (GO:0045625)3.42318330
34neuromuscular process controlling balance (GO:0050885)3.41785243
35synaptic vesicle maturation (GO:0016188)3.41217472
36glycolipid catabolic process (GO:0019377)3.40840878
37myeloid dendritic cell differentiation (GO:0043011)3.39144762
38positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.37258403
39macrophage activation involved in immune response (GO:0002281)3.35947058
40negative regulation of Ras GTPase activity (GO:0034261)3.32865666
41proline metabolic process (GO:0006560)3.32780559
42regulation of chronic inflammatory response (GO:0002676)3.29186434
43synaptic vesicle endocytosis (GO:0048488)3.27190995
44glial cell migration (GO:0008347)3.27164058
45activation of MAPKKK activity (GO:0000185)3.24812536
46negative regulation of JAK-STAT cascade (GO:0046426)3.24624706
47regulation of short-term neuronal synaptic plasticity (GO:0048172)3.22102632
48branching involved in labyrinthine layer morphogenesis (GO:0060670)3.19176899
49regulation of cholesterol storage (GO:0010885)3.18377438
50positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.16450286
51mitotic G1 DNA damage checkpoint (GO:0031571)3.16005484
52low-density lipoprotein particle clearance (GO:0034383)3.12925443
53establishment or maintenance of apical/basal cell polarity (GO:0035088)3.12847457
54establishment or maintenance of bipolar cell polarity (GO:0061245)3.12847457
55modulation by symbiont of host defense response (GO:0052031)3.12711574
56modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.12711574
57modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.12711574
58positive regulation by organism of defense response of other organism involved in symbiotic interact3.12711574
59modulation by symbiont of host immune response (GO:0052553)3.12711574
60positive regulation by symbiont of host defense response (GO:0052509)3.12711574
61monocyte chemotaxis (GO:0002548)3.09060389
62vocalization behavior (GO:0071625)3.08946414
63adhesion of symbiont to host cell (GO:0044650)3.08478837
64virion attachment to host cell (GO:0019062)3.08478837
65negative regulation of cytokine production involved in immune response (GO:0002719)3.07583890
66negative regulation of myeloid cell apoptotic process (GO:0033033)3.06174743
67germinal center formation (GO:0002467)3.05963463
68cellular response to thyroid hormone stimulus (GO:0097067)3.05009021
69cellular response to ATP (GO:0071318)3.04791247
70adhesion of symbiont to host (GO:0044406)3.02935314
71synaptic vesicle docking involved in exocytosis (GO:0016081)3.02560794
72negative regulation of catenin import into nucleus (GO:0035414)3.00934355
73regulation of heat generation (GO:0031650)2.98574509
74negative regulation of chondrocyte differentiation (GO:0032331)2.98360339
75positive regulation of dendritic spine morphogenesis (GO:0061003)2.98259131
76establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.96637307
77anterior/posterior axis specification, embryo (GO:0008595)2.96313959
78response to muramyl dipeptide (GO:0032495)2.95796270
79sodium ion export (GO:0071436)2.95713835
80regulation of macrophage chemotaxis (GO:0010758)2.94926991
81positive regulation of NF-kappaB import into nucleus (GO:0042346)2.94516835
82positive regulation of type 2 immune response (GO:0002830)2.94216397
83embryonic camera-type eye development (GO:0031076)2.93125299
84cellular response to lipopolysaccharide (GO:0071222)2.90636475
85nodal signaling pathway (GO:0038092)2.90518230
86convergent extension (GO:0060026)2.90380641
87regulation of interferon-alpha production (GO:0032647)2.89319590
88cellular response to type I interferon (GO:0071357)2.89139623
89type I interferon signaling pathway (GO:0060337)2.89139623
90regulation of cAMP-dependent protein kinase activity (GO:2000479)2.88976301
91transcription from mitochondrial promoter (GO:0006390)2.87537164
92positive regulation of synapse maturation (GO:0090129)2.87298375
93apoptotic process involved in morphogenesis (GO:0060561)2.86503908
94dendritic spine morphogenesis (GO:0060997)2.86416186
95response to type I interferon (GO:0034340)2.86355777
96ceramide catabolic process (GO:0046514)2.86299925
97immunoglobulin mediated immune response (GO:0016064)2.86042419
98regulation of glomerular filtration (GO:0003093)2.85617146
99membrane lipid catabolic process (GO:0046466)2.84336440
100modulation by symbiont of host cellular process (GO:0044068)2.84259446
101glial cell proliferation (GO:0014009)2.83303902
102embryonic placenta development (GO:0001892)2.82896049
103interferon-gamma-mediated signaling pathway (GO:0060333)2.81682278
104regulation of translational fidelity (GO:0006450)2.81600357
105regulation of T-helper 2 cell differentiation (GO:0045628)2.80544567
106hypotonic response (GO:0006971)2.78777148
107cellular response to molecule of bacterial origin (GO:0071219)2.78573391
108synaptic vesicle exocytosis (GO:0016079)2.75887730
109regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.75713602
110negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.75444378
111adherens junction assembly (GO:0034333)2.75366525
112positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.74782090
113establishment of nucleus localization (GO:0040023)2.74368574
114regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.74272345
115N-glycan processing (GO:0006491)2.74001067
116anatomical structure regression (GO:0060033)2.73052743
117regulation of clathrin-mediated endocytosis (GO:2000369)2.72441984
118G1 DNA damage checkpoint (GO:0044783)2.72350521
119myeloid dendritic cell activation (GO:0001773)2.72252283
120positive regulation of Cdc42 GTPase activity (GO:0043089)2.71436243
121regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.70671142
122regulation of dendritic cell antigen processing and presentation (GO:0002604)2.70005467
123positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.69916487
124glutamate secretion (GO:0014047)2.69654429
125regulation of heterotypic cell-cell adhesion (GO:0034114)2.69403012
126mitotic G1/S transition checkpoint (GO:0044819)2.67982119
127sphingolipid catabolic process (GO:0030149)2.66729164
128dendritic cell differentiation (GO:0097028)2.66517066
129collecting duct development (GO:0072044)2.65657153
130positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.63572857
131regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.62037624
132neutrophil activation involved in immune response (GO:0002283)2.62006770
133regulation of ARF GTPase activity (GO:0032312)2.61602174
134response to protozoan (GO:0001562)2.61544798
135protein heterotrimerization (GO:0070208)2.58293782
136proline transport (GO:0015824)2.58202140
137positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.57017521
138negative regulation of cartilage development (GO:0061037)2.56582399
139regulation of interferon-beta biosynthetic process (GO:0045357)2.56474044
140angiotensin maturation (GO:0002003)2.56335666
141regulation of neuronal synaptic plasticity (GO:0048168)2.56240242
142labyrinthine layer development (GO:0060711)2.56117412
143trophectodermal cell differentiation (GO:0001829)2.55224985
144positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.55127701
145cell-cell junction maintenance (GO:0045217)2.54680387
146positive regulation of transcription factor import into nucleus (GO:0042993)2.54572358
147barbed-end actin filament capping (GO:0051016)2.54205715
148positive regulation of interleukin-6 production (GO:0032755)2.53818336
149regulation of nitric oxide biosynthetic process (GO:0045428)2.53014280
150positive regulation of extracellular matrix organization (GO:1903055)2.51807786
151positive regulation of nitric oxide biosynthetic process (GO:0045429)2.51337425
152* regulation of podosome assembly (GO:0071801)2.51122309
153negative regulation of erythrocyte differentiation (GO:0045647)2.50350287
154hippo signaling (GO:0035329)2.49842603
155pinocytosis (GO:0006907)2.49694604
156regulation of NFAT protein import into nucleus (GO:0051532)2.49088608
157exploration behavior (GO:0035640)2.48913901
158decidualization (GO:0046697)2.47988108
159pre-miRNA processing (GO:0031054)2.47021703
160protein targeting to lysosome (GO:0006622)2.46977781
161establishment of protein localization to vacuole (GO:0072666)2.46977781
162protein targeting to vacuole (GO:0006623)2.46977781
163detection of molecule of bacterial origin (GO:0032490)2.46936194
164negative regulation of nitric oxide biosynthetic process (GO:0045019)2.46023640
165planar cell polarity pathway involved in neural tube closure (GO:0090179)2.45942821
166regulation of posttranscriptional gene silencing (GO:0060147)2.45785380
167regulation of gene silencing by miRNA (GO:0060964)2.45785380
168regulation of gene silencing by RNA (GO:0060966)2.45785380
169regulation of interferon-gamma biosynthetic process (GO:0045072)2.45761218
170regulation of type I interferon-mediated signaling pathway (GO:0060338)2.45665751
171regulation of interleukin-12 production (GO:0032655)2.45173947
172dendrite morphogenesis (GO:0048813)2.45138814
173regulation of dendritic spine morphogenesis (GO:0061001)2.44659072
174neuromuscular process controlling posture (GO:0050884)2.44498342
175negative regulation of glial cell proliferation (GO:0060253)2.44253383
176negative regulation of lipid storage (GO:0010888)2.44101405
177defense response to protozoan (GO:0042832)2.44053815
178positive regulation of interferon-alpha production (GO:0032727)2.43762018
179neuromuscular process (GO:0050905)2.43212902
180spinal cord development (GO:0021510)2.42954864
181protein retention in ER lumen (GO:0006621)2.41935896
182cyclooxygenase pathway (GO:0019371)2.41915675
183cellular response to biotic stimulus (GO:0071216)2.41809979
184regulation of glutamate receptor signaling pathway (GO:1900449)2.41673852
185renal system process involved in regulation of blood volume (GO:0001977)2.40771752
186response to thyroid hormone (GO:0097066)2.40291884
187regulation of interleukin-8 biosynthetic process (GO:0045414)2.40265173
188regulation of type 2 immune response (GO:0002828)2.39313344
189cellular potassium ion homeostasis (GO:0030007)2.38434867
190asymmetric protein localization (GO:0008105)2.38221648
191spliceosomal tri-snRNP complex assembly (GO:0000244)2.37728583
192histone H4-K12 acetylation (GO:0043983)2.36474590
193neural tube closure (GO:0001843)2.36285796
194negative regulation of GTPase activity (GO:0034260)2.35626589
195negative regulation of GTP catabolic process (GO:0033125)2.35626589
196dendritic spine organization (GO:0097061)2.35330568
197plasma membrane repair (GO:0001778)2.34655295
198positive regulation of dendrite morphogenesis (GO:0050775)2.33913060
199regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.31753964

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.38428742
2NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.35014764
3* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.22959264
4* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.21241444
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.12883645
6* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.96252247
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.88504493
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.88437925
9ERG_21242973_ChIP-ChIP_JURKAT_Human2.69281362
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.64021361
11* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.59858495
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.49745050
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.37827648
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.37518720
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.31858688
16ZFP281_27345836_Chip-Seq_ESCs_Mouse2.28226367
17* LXR_22292898_ChIP-Seq_THP-1_Human2.15044792
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.13681234
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.13290833
20* KDM2B_26808549_Chip-Seq_K562_Human2.12010838
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.11060007
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.11060007
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.11060007
24* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.08572537
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.08311108
26* SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.07741277
27ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.07134732
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.06280658
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.03635118
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.01115662
31* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.92511468
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.91186934
33ZNF263_19887448_ChIP-Seq_K562_Human1.85771535
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.82518852
35VDR_24763502_ChIP-Seq_THP-1_Human1.79127283
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.78804088
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.78742677
38KDM2B_26808549_Chip-Seq_DND41_Human1.76521679
39* RACK7_27058665_Chip-Seq_MCF-7_Human1.76413189
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.72607319
41MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.71076324
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.69369254
43* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.68368584
44NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.68088954
45MYC_22102868_ChIP-Seq_BL_Human1.67009895
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.66845881
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.65064980
48TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.64292097
49ESR1_15608294_ChIP-ChIP_MCF-7_Human1.61740079
50POU5F1_16518401_ChIP-PET_MESCs_Mouse1.60712883
51RARB_27405468_Chip-Seq_BRAIN_Mouse1.60316140
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.59888730
53CLOCK_20551151_ChIP-Seq_293T_Human1.59882553
54* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.58632013
55* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.57109243
56CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.56392782
57RING1B_27294783_Chip-Seq_NPCs_Mouse1.55306595
58* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.54931226
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.53943128
60* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.51622885
61TP53_20018659_ChIP-ChIP_R1E_Mouse1.47628732
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46775059
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.46517168
64* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.45751165
65* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.41244866
66ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.41059349
67KDM2B_26808549_Chip-Seq_JURKAT_Human1.40042758
68RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39388375
69DROSHA_22980978_ChIP-Seq_HELA_Human1.39376877
70STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39375392
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39251797
72* CDX2_20551321_ChIP-Seq_CACO-2_Human1.38819393
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38650199
74FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.38423756
75JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37919722
76STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37829844
77RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36922317
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.36612729
79CREB1_26743006_Chip-Seq_LNCaP_Human1.35385720
80SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35112482
81ESR1_21235772_ChIP-Seq_MCF-7_Human1.34834490
82EZH2_18974828_ChIP-Seq_MESCs_Mouse1.33871123
83RNF2_18974828_ChIP-Seq_MESCs_Mouse1.33871123
84* SPI1_23127762_ChIP-Seq_K562_Human1.33551161
85* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.32402636
86* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32332264
87RNF2_27304074_Chip-Seq_ESCs_Mouse1.30957188
88UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29517081
89RXR_22158963_ChIP-Seq_LIVER_Mouse1.29339010
90VDR_24787735_ChIP-Seq_THP-1_Human1.29120704
91* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.29001093
92CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28837434
93CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28298706
94KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.27809501
95PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25097584
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24566267
97RUNX1_22412390_ChIP-Seq_EML_Mouse1.24382822
98DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23937701
99* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22072593
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21860630
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19956924
102PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19240175
103IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.19197874
104TET1_21490601_ChIP-Seq_MESCs_Mouse1.19056271
105SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18596561
106* RING1B_27294783_Chip-Seq_ESCs_Mouse1.18378160
107* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.17848002
108EZH2_22144423_ChIP-Seq_EOC_Human1.17157467
109MAF_26560356_Chip-Seq_TH1_Human1.17051436
110SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16906687
111KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16605075
112TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16335065
113GATA1_19941827_ChIP-Seq_MEL_Mouse1.15980242
114PPARA_22158963_ChIP-Seq_LIVER_Mouse1.15054795
115RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14987685
116* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14495966
117MTF2_20144788_ChIP-Seq_MESCs_Mouse1.13972530
118CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13333880
119SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.12620971
120TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12480170
121* RUNX1_27514584_Chip-Seq_MCF-7_Human1.11537230
122CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11505267
123CTCF_27219007_Chip-Seq_Bcells_Human1.11445587
124* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10469589
125* TP53_23651856_ChIP-Seq_MEFs_Mouse1.10065486
126REST_21632747_ChIP-Seq_MESCs_Mouse1.09886748
127VDR_21846776_ChIP-Seq_THP-1_Human1.09616361
128DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09429399
129NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09091072
130UBF1/2_26484160_Chip-Seq_HMECs_Human1.08909793
131* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.08428171
132WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06398378
133SMC4_20622854_ChIP-Seq_HELA_Human1.06367522
134* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04936139
135SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.04868000
136STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.04704874
137* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03927759
138GATA1_19941826_ChIP-Seq_K562_Human1.03648002
139ATF3_27146783_Chip-Seq_COLON_Human1.03150762
140SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.03020346
141CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02663821
142OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.02519068
143GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02457048
144SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01708793
145SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01703176
146* REST_18959480_ChIP-ChIP_MESCs_Mouse1.01078081
147TCF7_22412390_ChIP-Seq_EML_Mouse0.99992005
148TET1_21451524_ChIP-Seq_MESCs_Mouse0.99727459
149P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99100868
150* TP53_22127205_ChIP-Seq_IMR90_Human0.98865892
151HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97486260
152LXR_22158963_ChIP-Seq_LIVER_Mouse0.97056865
153JARID2_20064375_ChIP-Seq_MESCs_Mouse0.96856463
154SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.96719196
155* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.96218306
156* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96040846
157GATA2_21666600_ChIP-Seq_HMVEC_Human0.95953754
158* PU_27001747_Chip-Seq_BMDM_Mouse0.95912984
159GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95800289
160MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95315183
161* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95197247
162* SOX2_20726797_ChIP-Seq_SW620_Human0.95042310
163ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93885173

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.22953514
2MP0004859_abnormal_synaptic_plasticity4.49825657
3MP0005058_abnormal_lysosome_morphology3.87135087
4MP0003283_abnormal_digestive_organ3.67849848
5MP0002139_abnormal_hepatobiliary_system3.51312623
6MP0009840_abnormal_foam_cell3.29355849
7MP0003436_decreased_susceptibility_to3.23644737
8MP0004510_myositis3.13745897
9MP0004858_abnormal_nervous_system3.05362553
10MP0010030_abnormal_orbit_morphology3.03080632
11MP0002148_abnormal_hypersensitivity_rea2.88549569
12MP0003705_abnormal_hypodermis_morpholog2.83945966
13MP0006082_CNS_inflammation2.76750844
14MP0003300_gastrointestinal_ulcer2.71483647
15MP0009785_altered_susceptibility_to2.71259766
16MP0005451_abnormal_body_composition2.63330805
17MP0005171_absent_coat_pigmentation2.61031409
18MP0005623_abnormal_meninges_morphology2.55601610
19MP0004233_abnormal_muscle_weight2.52206153
20MP0010234_abnormal_vibrissa_follicle2.51663438
21MP0009278_abnormal_bone_marrow2.49218373
22MP0002653_abnormal_ependyma_morphology2.36112858
23MP0010352_gastrointestinal_tract_polyps2.33914557
24MP0005076_abnormal_cell_differentiation2.29951618
25MP0003724_increased_susceptibility_to2.19697626
26MP0005000_abnormal_immune_tolerance2.13756402
27MP0003119_abnormal_digestive_system2.13655824
28MP0004947_skin_inflammation2.12526263
29MP0005387_immune_system_phenotype2.12100997
30MP0001790_abnormal_immune_system2.12100997
31MP0002419_abnormal_innate_immunity2.11589733
32MP0005025_abnormal_response_to2.01254500
33MP0000604_amyloidosis1.98371810
34MP0009764_decreased_sensitivity_to1.98202525
35MP0001835_abnormal_antigen_presentation1.98056442
36MP0000343_altered_response_to1.97439329
37MP0001533_abnormal_skeleton_physiology1.94643241
38MP0000537_abnormal_urethra_morphology1.93758675
39MP0003635_abnormal_synaptic_transmissio1.92044242
40MP0008004_abnormal_stomach_pH1.88246735
41MP0005671_abnormal_response_to1.83231252
42MP0010155_abnormal_intestine_physiology1.81793516
43MP0002063_abnormal_learning/memory/cond1.76325503
44MP0000858_altered_metastatic_potential1.71563694
45MP0001849_ear_inflammation1.71522016
46MP0003191_abnormal_cellular_cholesterol1.70162444
47* MP0002998_abnormal_bone_remodeling1.69439205
48MP0005257_abnormal_intraocular_pressure1.68893595
49MP0002452_abnormal_antigen_presenting1.65933806
50MP0006054_spinal_hemorrhage1.65029727
51MP0004270_analgesia1.61742333
52MP0000685_abnormal_immune_system1.61500617
53MP0003890_abnormal_embryonic-extraembry1.57840859
54MP0003045_fibrosis1.57439638
55MP0002723_abnormal_immune_serum1.56539748
56MP0004133_heterotaxia1.55652128
57MP0003453_abnormal_keratinocyte_physiol1.53261668
58MP0000778_abnormal_nervous_system1.52051930
59MP0000462_abnormal_digestive_system1.52019664
60MP0003448_altered_tumor_morphology1.50029295
61MP0003172_abnormal_lysosome_physiology1.47615977
62* MP0001845_abnormal_inflammatory_respons1.44944275
63MP0001800_abnormal_humoral_immune1.43444045
64MP0005166_decreased_susceptibility_to1.42686057
65MP0003385_abnormal_body_wall1.41809678
66MP0008469_abnormal_protein_level1.39671375
67MP0003566_abnormal_cell_adhesion1.39441610
68MP0005464_abnormal_platelet_physiology1.37752829
69MP0003183_abnormal_peptide_metabolism1.35365634
70MP0001853_heart_inflammation1.35074377
71MP0000534_abnormal_ureter_morphology1.34747945
72MP0001348_abnormal_lacrimal_gland1.34532075
73MP0003091_abnormal_cell_migration1.32380283
74MP0005310_abnormal_salivary_gland1.31838691
75MP0002282_abnormal_trachea_morphology1.31056578
76MP0004811_abnormal_neuron_physiology1.30768790
77MP0004264_abnormal_extraembryonic_tissu1.30737579
78MP0003075_altered_response_to1.28173080
79MP0000955_abnormal_spinal_cord1.28046710
80MP0009053_abnormal_anal_canal1.26947716
81MP0002572_abnormal_emotion/affect_behav1.26549923
82MP0002064_seizures1.24809800
83MP0008260_abnormal_autophagy1.24785176
84MP0002249_abnormal_larynx_morphology1.24638151
85MP0003690_abnormal_glial_cell1.24634197
86MP0002084_abnormal_developmental_patter1.24516387
87MP0002733_abnormal_thermal_nociception1.23855948
88MP0005367_renal/urinary_system_phenotyp1.23738562
89MP0000516_abnormal_urinary_system1.23738562
90MP0001819_abnormal_immune_cell1.22133192
91MP0002420_abnormal_adaptive_immunity1.19963018
92MP0009333_abnormal_splenocyte_physiolog1.19592229
93MP0005397_hematopoietic_system_phenotyp1.17711248
94MP0001545_abnormal_hematopoietic_system1.17711248
95MP0002405_respiratory_system_inflammati1.17458019
96MP0000467_abnormal_esophagus_morphology1.16984155
97MP0003755_abnormal_palate_morphology1.15361092
98MP0009046_muscle_twitch1.15134879
99MP0004885_abnormal_endolymph1.13868418
100MP0002796_impaired_skin_barrier1.13822046
101MP0005248_abnormal_Harderian_gland1.12762434
102MP0009780_abnormal_chondrocyte_physiolo1.08957469
103MP0003861_abnormal_nervous_system1.08413323
104MP0004197_abnormal_fetal_growth/weight/1.08005178
105MP0005167_abnormal_blood-brain_barrier1.07585373
106MP0003115_abnormal_respiratory_system1.05872223
107MP0005164_abnormal_response_to1.01824808
108MP0003942_abnormal_urinary_system1.01464138
109MP0002085_abnormal_embryonic_tissue1.01271716
110* MP0002086_abnormal_extraembryonic_tissu0.98551052
111MP0009745_abnormal_behavioral_response0.97784001
112MP0000733_abnormal_muscle_development0.95846091
113MP0003941_abnormal_skin_development0.95624807
114MP0005390_skeleton_phenotype0.94500501
115MP0000762_abnormal_tongue_morphology0.94405448
116MP0002152_abnormal_brain_morphology0.94132244
117MP0000920_abnormal_myelination0.93626025
118MP0000579_abnormal_nail_morphology0.93288895
119MP0001970_abnormal_pain_threshold0.93248507
120MP0004272_abnormal_basement_membrane0.93111219
121MP0002332_abnormal_exercise_endurance0.92954453
122MP0003935_abnormal_craniofacial_develop0.92842467
123MP0001293_anophthalmia0.92710997
124MP0002932_abnormal_joint_morphology0.91715063
125MP0005365_abnormal_bile_salt0.90647334
126MP0003329_amyloid_beta_deposits0.89362894
127MP0002089_abnormal_postnatal_growth/wei0.88341745
128MP0002111_abnormal_tail_morphology0.87928123
129MP0000569_abnormal_digit_pigmentation0.87619668
130MP0002254_reproductive_system_inflammat0.87237491
131MP0002877_abnormal_melanocyte_morpholog0.87054324
132MP0003880_abnormal_central_pattern0.86557267
133MP0001663_abnormal_digestive_system0.86132852
134MP0003656_abnormal_erythrocyte_physiolo0.85886687
135MP0002184_abnormal_innervation0.85615603
136* MP0002116_abnormal_craniofacial_bone0.85143728
137MP0001216_abnormal_epidermal_layer0.84632921
138MP0002882_abnormal_neuron_morphology0.83562831
139MP0005023_abnormal_wound_healing0.83144354
140MP0000716_abnormal_immune_system0.81904244
141MP0008438_abnormal_cutaneous_collagen0.80085102
142MP0005165_increased_susceptibility_to0.79961796
143MP0005508_abnormal_skeleton_morphology0.79730377
144MP0002909_abnormal_adrenal_gland0.79632966
145MP0003634_abnormal_glial_cell0.79487685
146MP0003795_abnormal_bone_structure0.78007446
147MP0002138_abnormal_hepatobiliary_system0.77844158
148MP0005645_abnormal_hypothalamus_physiol0.77093878
149MP0008057_abnormal_DNA_replication0.75938708
150MP0005360_urolithiasis0.75387894
151MP0000249_abnormal_blood_vessel0.74829909
152MP0002896_abnormal_bone_mineralization0.74325741
153MP0009763_increased_sensitivity_to0.74318525
154MP0001697_abnormal_embryo_size0.73682000
155MP0008961_abnormal_basal_metabolism0.73033235
156* MP0000432_abnormal_head_morphology0.72715245
157MP0008874_decreased_physiological_sensi0.72498364
158MP0000751_myopathy0.72287020
159MP0006072_abnormal_retinal_apoptosis0.71028520
160MP0003122_maternal_imprinting0.71010131
161MP0000470_abnormal_stomach_morphology0.70590045
162MP0002697_abnormal_eye_size0.69595094
163MP0001440_abnormal_grooming_behavior0.68281999
164MP0003806_abnormal_nucleotide_metabolis0.68149008
165MP0008770_decreased_survivor_rate0.67554160
166MP0002114_abnormal_axial_skeleton0.67497724
167MP0002734_abnormal_mechanical_nocicepti0.67325830
168* MP0001340_abnormal_eyelid_morphology0.66975894
169MP0003195_calcinosis0.65948533
170MP0000609_abnormal_liver_physiology0.65718389
171MP0005666_abnormal_adipose_tissue0.64691393
172MP0009765_abnormal_xenobiotic_induced0.64610047
173MP0005381_digestive/alimentary_phenotyp0.64398001
174MP0000767_abnormal_smooth_muscle0.64349716
175MP0000490_abnormal_crypts_of0.63282032
176MP0002933_joint_inflammation0.63007729
177MP0002429_abnormal_blood_cell0.61995600
178MP0003279_aneurysm0.61435106

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)5.79311372
2Abnormality of glycosphingolipid metabolism (HP:0004343)5.79311372
3Abnormality of glycolipid metabolism (HP:0010969)5.79311372
4Systemic lupus erythematosus (HP:0002725)4.51346206
5Vacuolated lymphocytes (HP:0001922)4.22714107
6Increased cerebral lipofuscin (HP:0011813)4.15485686
7Annular pancreas (HP:0001734)4.01063748
8Abnormality of macrophages (HP:0004311)3.99624125
9Neurofibrillary tangles (HP:0002185)3.91940025
10Turricephaly (HP:0000262)3.90946429
11Loss of speech (HP:0002371)3.87621608
12Disinhibition (HP:0000734)3.61430176
13Cerebral aneurysm (HP:0004944)3.50342245
14Eczematoid dermatitis (HP:0000976)3.31030378
15Increased neuronal autofluorescent lipopigment (HP:0002074)3.26913186
16Nuclear cataract (HP:0100018)3.24042759
17Ulnar bowing (HP:0003031)3.20996755
18Glomerulonephritis (HP:0000099)3.11772297
19Orchitis (HP:0100796)3.06961769
20Coronal craniosynostosis (HP:0004440)3.06833729
21Cerebral inclusion bodies (HP:0100314)3.06189569
22Recurrent bacterial skin infections (HP:0005406)3.02367057
23Axonal loss (HP:0003447)2.99356787
24Abnormality of the lower motor neuron (HP:0002366)2.98682431
25Myokymia (HP:0002411)2.96626679
26Mutism (HP:0002300)2.92558604
27Rib fusion (HP:0000902)2.90396091
28Alopecia of scalp (HP:0002293)2.90322076
29Retrobulbar optic neuritis (HP:0100654)2.81023253
30Optic neuritis (HP:0100653)2.81023253
31Apathy (HP:0000741)2.79777522
32Purpura (HP:0000979)2.75102922
33Thin bony cortex (HP:0002753)2.73663984
34Mediastinal lymphadenopathy (HP:0100721)2.70702650
35Myocardial infarction (HP:0001658)2.70315077
36Diminished motivation (HP:0000745)2.67922986
37Short humerus (HP:0005792)2.64714735
38Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.62933065
39Recurrent abscess formation (HP:0002722)2.62729647
40Concave nail (HP:0001598)2.60950617
41Shallow orbits (HP:0000586)2.60517030
42Neuronal loss in central nervous system (HP:0002529)2.56909857
43Autoimmune thrombocytopenia (HP:0001973)2.56507356
44Malnutrition (HP:0004395)2.54935063
45Complement deficiency (HP:0004431)2.51808889
46Amyloidosis (HP:0011034)2.51649327
47Hypercortisolism (HP:0001578)2.44981714
48Myositis (HP:0100614)2.43980666
49Congenital hip dislocation (HP:0001374)2.43178935
50Vertebral hypoplasia (HP:0008417)2.42148362
51Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.42148362
52Metaphyseal irregularity (HP:0003025)2.41422122
53Deep venous thrombosis (HP:0002625)2.39932363
54Recurrent gram-negative bacterial infections (HP:0005420)2.38831559
55Male infertility (HP:0003251)2.38524174
56Abnormality of the aortic arch (HP:0012303)2.36951254
57Increased serum ferritin (HP:0003281)2.36444706
58Facial hemangioma (HP:0000329)2.34203147
59Abnormality of the astrocytes (HP:0100707)2.33909069
60Astrocytoma (HP:0009592)2.33909069
61Abnormality of complement system (HP:0005339)2.33611515
62Hemorrhage of the eye (HP:0011885)2.33498474
63Aplasia/hypoplasia of the humerus (HP:0006507)2.31058685
64Ankyloglossia (HP:0010296)2.29516237
65Bowed forearm bones (HP:0003956)2.26496097
66Bowing of the arm (HP:0006488)2.26496097
67Bone pain (HP:0002653)2.22583171
68Vertebral compression fractures (HP:0002953)2.22253373
69Distal upper limb amyotrophy (HP:0007149)2.19791768
70Upper limb amyotrophy (HP:0009129)2.19791768
71Obstructive sleep apnea (HP:0002870)2.19572965
72Interstitial pulmonary disease (HP:0006530)2.14869409
73Alacrima (HP:0000522)2.13461338
74Flat acetabular roof (HP:0003180)2.12767108
75Hyperacusis (HP:0010780)2.12427983
76Protrusio acetabuli (HP:0003179)2.11437710
77Thoracic kyphosis (HP:0002942)2.08679613
78Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.07753636
79Abnormality of the lumbar spine (HP:0100712)2.07669619
80Abnormality of the vasculature of the conjunctiva (HP:0008054)2.05279648
81Urinary glycosaminoglycan excretion (HP:0003541)2.04754655
82Mucopolysacchariduria (HP:0008155)2.04754655
83Genu recurvatum (HP:0002816)2.03267145
84Prolonged neonatal jaundice (HP:0006579)2.02625014
85Renal duplication (HP:0000075)2.01525539
86Congenital glaucoma (HP:0001087)2.01036863
87Segmental peripheral demyelination/remyelination (HP:0003481)2.00810142
88Pathologic fracture (HP:0002756)1.99503353
89Pustule (HP:0200039)1.99141587
90Bronchomalacia (HP:0002780)1.98385652
91Keratoconjunctivitis sicca (HP:0001097)1.97951179
92Hand muscle atrophy (HP:0009130)1.97108866
93Narrow nasal bridge (HP:0000446)1.95094046
94Dementia (HP:0000726)1.94545181
95Atrophic scars (HP:0001075)1.94267720
96Personality changes (HP:0000751)1.92431901
97Upper motor neuron abnormality (HP:0002127)1.91891084
98Gingivitis (HP:0000230)1.91586952
99Insomnia (HP:0100785)1.90959144
100Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90920822
101Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90920822
102Abnormality of polysaccharide metabolism (HP:0011012)1.90920822
103Choanal stenosis (HP:0000452)1.90521265
104Rectovaginal fistula (HP:0000143)1.89552154
105Rectal fistula (HP:0100590)1.89552154
106Pointed chin (HP:0000307)1.89178825
107Short chin (HP:0000331)1.88595251
108Abnormality of the Achilles tendon (HP:0005109)1.87899461
109Vasculitis (HP:0002633)1.86705346
110Focal seizures (HP:0007359)1.85793207
111Broad thumb (HP:0011304)1.85184648
112Progressive neurologic deterioration (HP:0002344)1.83736227
113Visual hallucinations (HP:0002367)1.83323324
114Orthostatic hypotension (HP:0001278)1.83144166
115Progressive sensorineural hearing impairment (HP:0000408)1.81908743
116Shawl scrotum (HP:0000049)1.81776273
117Pulmonary infiltrates (HP:0002113)1.81313017
118Abnormality of oral frenula (HP:0000190)1.80873024
119Hyperextensible skin (HP:0000974)1.80870284
120Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.80412269
121Protuberant abdomen (HP:0001538)1.80347538
122Nephritis (HP:0000123)1.80090377
123Premature rupture of membranes (HP:0001788)1.79707771
124Petechiae (HP:0000967)1.79063980
125Cervical subluxation (HP:0003308)1.77611729
126Xanthomatosis (HP:0000991)1.77245810
127Gastrointestinal stroma tumor (HP:0100723)1.76833184
128Inappropriate behavior (HP:0000719)1.76174633
129Mildly elevated creatine phosphokinase (HP:0008180)1.76164974
130Vertebral fusion (HP:0002948)1.75879443
131Peripheral demyelination (HP:0011096)1.74712887
132Nausea (HP:0002018)1.74068736
133Premature loss of primary teeth (HP:0006323)1.73246421
134Clumsiness (HP:0002312)1.73210409
135Abnormality of the thoracic spine (HP:0100711)1.72405757
136Asymmetric septal hypertrophy (HP:0001670)1.71605194
137Selective tooth agenesis (HP:0001592)1.71066514
138Emphysema (HP:0002097)1.70652523
139Vaginal fistula (HP:0004320)1.70419555
140Esophageal varix (HP:0002040)1.69945564
141Atonic seizures (HP:0010819)1.68873883
142Bladder diverticulum (HP:0000015)1.68743145
143Achilles tendon contracture (HP:0001771)1.68605030
144Hematochezia (HP:0002573)1.68268496
145Hamartoma (HP:0010566)1.67661987
146Dysostosis multiplex (HP:0000943)1.67440052
147Abnormality of iron homeostasis (HP:0011031)1.67024585
148Muscle fibrillation (HP:0010546)1.66361965
149Intestinal fistula (HP:0100819)1.66123474
150Cupped ribs (HP:0000887)1.66059596
151Thick nail (HP:0001805)1.65987784
152Gangrene (HP:0100758)1.65410784
153Keratoconjunctivitis (HP:0001096)1.64815803
154Hyperparathyroidism (HP:0000843)1.64546396
155Tongue fasciculations (HP:0001308)1.64314185
156Anteriorly placed anus (HP:0001545)1.64044580
157Milia (HP:0001056)1.63803786
158Hypophosphatemia (HP:0002148)1.63358165
159Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.62374223
160Fragile skin (HP:0001030)1.62306993
161Macroorchidism (HP:0000053)1.61624352
162Elevated alkaline phosphatase (HP:0003155)1.61614597
163Chronic obstructive pulmonary disease (HP:0006510)1.60917489
164Obstructive lung disease (HP:0006536)1.60917489
165Focal motor seizures (HP:0011153)1.60882947
166Acrocyanosis (HP:0001063)1.60627852
167Spinal muscular atrophy (HP:0007269)1.60158039
168Flared iliac wings (HP:0002869)1.59385297
169Aneurysm (HP:0002617)1.59169874
170Restrictive lung disease (HP:0002091)1.59140515
171Action tremor (HP:0002345)1.58861921
172Short 1st metacarpal (HP:0010034)1.58171909
173Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.58171909
174Split hand (HP:0001171)1.57722638
175Megalencephaly (HP:0001355)1.57332855
176Elfin facies (HP:0004428)1.56450085
177Deviation of the hallux (HP:0010051)1.56339134
178Abnormality of the gastric mucosa (HP:0004295)1.54614397
179Abnormality of the periventricular white matter (HP:0002518)1.53271807
180Heterotopia (HP:0002282)1.52741112
181Abnormality of the labia minora (HP:0012880)1.52622498
182Poikiloderma (HP:0001029)1.52305460
183Hallux valgus (HP:0001822)1.51279123
184Ankle contracture (HP:0006466)1.50283166
185Deep palmar crease (HP:0006191)1.49262007
186Supranuclear gaze palsy (HP:0000605)1.48986757
187Growth hormone excess (HP:0000845)1.48985817
188Neoplasm of the heart (HP:0100544)1.48965328
189Bowel diverticulosis (HP:0005222)1.48933560

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK36.24539927
2ICK4.89226391
3NME23.42546138
4MAP3K93.20730367
5BMX2.84635344
6MAP3K142.79513924
7LATS22.64357741
8TRIB32.52863340
9MAP3K62.44635116
10RIPK12.42985930
11MAPK152.42817256
12TBK12.19800191
13GRK72.15808820
14EPHA42.07868495
15PRKD32.06525794
16DAPK12.05399554
17EPHA22.03946540
18RIPK42.01334873
19UHMK11.94884113
20PAK61.92842722
21MAP3K111.92275327
22FGFR41.89942709
23IRAK41.88922381
24KSR21.76248168
25NTRK31.75338140
26MAP3K31.65758760
27TYK21.63312315
28PRKD21.61678536
29MST1R1.60880759
30DYRK1B1.52949950
31BLK1.47576141
32IKBKB1.46516314
33NTRK11.41320456
34MAP4K11.40272285
35MARK11.39957924
36PINK11.37316200
37PTK21.34440906
38TGFBR21.31513112
39MAP3K131.28894234
40CHUK1.28814569
41NTRK21.28079685
42STK381.27230070
43IKBKE1.26913778
44DAPK21.26912037
45MOS1.22869869
46IRAK21.22782414
47ALK1.21890710
48TAOK11.21679615
49FER1.17355120
50MINK11.16950517
51MAP2K31.16397946
52ARAF1.15145884
53PHKG21.14174111
54PHKG11.14174111
55* PDGFRA1.13580080
56PKN21.12605752
57MAP3K11.12588593
58MAP3K101.12525951
59KSR11.12222493
60EPHB21.11119367
61CDK121.08775585
62SMG11.07789905
63PTK61.05510687
64SIK21.04536759
65CAMKK11.03414251
66LMTK21.01656531
67PRPF4B1.00998081
68CSF1R0.99364321
69JAK30.98222908
70ABL20.95964426
71CDK60.95064787
72MAP3K20.94753243
73PAK40.92883709
74LATS10.92805304
75MTOR0.92376230
76DMPK0.92300290
77CAMK1D0.87775677
78SIK30.87671471
79* CDC42BPA0.87500404
80JAK10.87242664
81* TYRO30.86834044
82EPHB10.85663123
83AKT30.85053492
84PAK20.84249629
85IRAK10.83899610
86PAK30.82169951
87PIM20.82101277
88GSK3A0.81729027
89TTN0.81180200
90BMPR20.80013962
91NEK10.79736696
92TAOK20.76409254
93MAP3K40.76343704
94ZAP700.76176860
95FGFR30.72730928
96TESK20.71932377
97* CSK0.71907463
98* CDK50.71567307
99YES10.69649454
100RAF10.69278436
101NEK90.68880309
102ACVR1B0.68838879
103FGFR10.68601408
104SCYL20.68174344
105RPS6KA20.67994312
106RET0.67587122
107PDPK10.64790906
108MAP3K50.63297188
109TRPM70.62887247
110RPS6KA10.60513817
111STK240.60445996
112CAMK2B0.60263011
113EEF2K0.60122244
114RPS6KL10.59935959
115RPS6KC10.59935959
116CDK70.57682302
117ERN10.57458067
118ERBB30.56642352
119PRKCZ0.55274174
120MAP2K10.53568356
121EGFR0.52854971
122DAPK30.52661477
123MARK20.52513463
124MAP2K20.52331250
125ERBB20.51531450
126SGK10.51263213
127MET0.50164647
128ADRBK20.49186058
129STK110.47149596
130MAPK100.46831371
131RPS6KA60.46668282
132JAK20.46197335
133TESK10.45376397
134PRKG20.45115246
135PRKAA10.44794825
136CAMK2A0.44307262
137* FGR0.42601095
138EPHA30.42099071
139HIPK20.41569810
140CAMK2G0.41149127
141PRKCI0.40952366
142MAP2K60.40750295
143MAPK40.40203950
144PRKD10.39243777
145SIK10.39176762
146* LYN0.37864241
147* RPS6KA30.37670259
148PRKCH0.37178959
149SYK0.35989670
150DYRK30.35605508
151MAPK110.35236414
152CAMK1G0.35099296
153AKT20.34567847
154PDK10.34040365
155* SRC0.33641062
156MAP3K80.32081613
157BRAF0.27833333
158HCK0.25405797
159MAPKAPK20.25198092

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.25553814
2Toll-like receptor signaling pathway_Homo sapiens_hsa046202.65494792
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.64149514
4Fatty acid biosynthesis_Homo sapiens_hsa000612.61241186
5Osteoclast differentiation_Homo sapiens_hsa043802.32458330
6Leishmaniasis_Homo sapiens_hsa051402.30075124
7Lysosome_Homo sapiens_hsa041422.29528258
8Staphylococcus aureus infection_Homo sapiens_hsa051502.22071336
9TNF signaling pathway_Homo sapiens_hsa046682.21297436
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.19014284
11Rheumatoid arthritis_Homo sapiens_hsa053232.18523531
12Pertussis_Homo sapiens_hsa051332.03173249
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.01176236
14Hippo signaling pathway_Homo sapiens_hsa043901.99470007
15Malaria_Homo sapiens_hsa051441.95706933
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.89693650
17Allograft rejection_Homo sapiens_hsa053301.88687475
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.86789879
19mTOR signaling pathway_Homo sapiens_hsa041501.85033535
20Asthma_Homo sapiens_hsa053101.82768610
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.77543502
22Legionellosis_Homo sapiens_hsa051341.72261720
23* Tuberculosis_Homo sapiens_hsa051521.71393165
24Graft-versus-host disease_Homo sapiens_hsa053321.70024224
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.68659798
26Synaptic vesicle cycle_Homo sapiens_hsa047211.65568638
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.63959812
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.63338689
29Hedgehog signaling pathway_Homo sapiens_hsa043401.62795984
30Toxoplasmosis_Homo sapiens_hsa051451.60138277
31Influenza A_Homo sapiens_hsa051641.59732996
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.59429597
33African trypanosomiasis_Homo sapiens_hsa051431.55445820
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.54469987
35Long-term potentiation_Homo sapiens_hsa047201.46072635
36* Adherens junction_Homo sapiens_hsa045201.43059044
37Glioma_Homo sapiens_hsa052141.42760760
38Basal cell carcinoma_Homo sapiens_hsa052171.39230761
39Dorso-ventral axis formation_Homo sapiens_hsa043201.37262247
40Notch signaling pathway_Homo sapiens_hsa043301.36328485
41* Gap junction_Homo sapiens_hsa045401.35416141
42Hepatitis C_Homo sapiens_hsa051601.32722431
43Olfactory transduction_Homo sapiens_hsa047401.32665085
44Autoimmune thyroid disease_Homo sapiens_hsa053201.31723981
45Gastric acid secretion_Homo sapiens_hsa049711.31707302
46Nicotine addiction_Homo sapiens_hsa050331.31676679
47* Tight junction_Homo sapiens_hsa045301.31147291
48Type I diabetes mellitus_Homo sapiens_hsa049401.28705147
49Endometrial cancer_Homo sapiens_hsa052131.27478586
50Circadian entrainment_Homo sapiens_hsa047131.26639868
51Axon guidance_Homo sapiens_hsa043601.26213851
52Salivary secretion_Homo sapiens_hsa049701.24023600
53Melanogenesis_Homo sapiens_hsa049161.23678589
54Wnt signaling pathway_Homo sapiens_hsa043101.23310021
55Amphetamine addiction_Homo sapiens_hsa050311.22970196
56Glutamatergic synapse_Homo sapiens_hsa047241.22504335
57* GnRH signaling pathway_Homo sapiens_hsa049121.20982269
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20205540
59* ErbB signaling pathway_Homo sapiens_hsa040121.19522413
60B cell receptor signaling pathway_Homo sapiens_hsa046621.19094286
61Dopaminergic synapse_Homo sapiens_hsa047281.18815777
62Phagosome_Homo sapiens_hsa041451.17781438
63* Proteoglycans in cancer_Homo sapiens_hsa052051.17202943
64Longevity regulating pathway - mammal_Homo sapiens_hsa042111.16414087
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14603122
66* Bladder cancer_Homo sapiens_hsa052191.14472417
67* Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.14310248
68* VEGF signaling pathway_Homo sapiens_hsa043701.13691040
69* Focal adhesion_Homo sapiens_hsa045101.13525437
70Chronic myeloid leukemia_Homo sapiens_hsa052201.12319385
71* Estrogen signaling pathway_Homo sapiens_hsa049151.10660772
72Colorectal cancer_Homo sapiens_hsa052101.10056634
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.10013230
74* GABAergic synapse_Homo sapiens_hsa047271.09563226
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08895347
76Long-term depression_Homo sapiens_hsa047301.08371989
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.08115432
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07762477
79Complement and coagulation cascades_Homo sapiens_hsa046101.07725609
80Galactose metabolism_Homo sapiens_hsa000521.07690110
81* Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06912516
82Choline metabolism in cancer_Homo sapiens_hsa052311.06722155
83Insulin secretion_Homo sapiens_hsa049111.04986724
84Mineral absorption_Homo sapiens_hsa049781.03785775
85Herpes simplex infection_Homo sapiens_hsa051681.03455881
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02554221
87MicroRNAs in cancer_Homo sapiens_hsa052061.02247424
88Cholinergic synapse_Homo sapiens_hsa047251.01846437
89Adipocytokine signaling pathway_Homo sapiens_hsa049201.01081922
90TGF-beta signaling pathway_Homo sapiens_hsa043501.00189872
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99977975
92* Chemokine signaling pathway_Homo sapiens_hsa040620.99720704
93Antigen processing and presentation_Homo sapiens_hsa046120.99617889
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99122850
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97332199
96Apoptosis_Homo sapiens_hsa042100.96972623
97Hematopoietic cell lineage_Homo sapiens_hsa046400.95342863
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95133258
99Measles_Homo sapiens_hsa051620.95002336
100Fructose and mannose metabolism_Homo sapiens_hsa000510.94357719
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.94153168
102Acute myeloid leukemia_Homo sapiens_hsa052210.93930915
103Viral myocarditis_Homo sapiens_hsa054160.93561288
104* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93501013
105* Oxytocin signaling pathway_Homo sapiens_hsa049210.93257730
106Oocyte meiosis_Homo sapiens_hsa041140.92969526
107Morphine addiction_Homo sapiens_hsa050320.91943531
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.91613870
109* Hepatitis B_Homo sapiens_hsa051610.90857869
110Sphingolipid metabolism_Homo sapiens_hsa006000.90040748
111* Rap1 signaling pathway_Homo sapiens_hsa040150.86884910
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.85496925
113Small cell lung cancer_Homo sapiens_hsa052220.85001438
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84774448
115Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84666483
116Type II diabetes mellitus_Homo sapiens_hsa049300.84577817
117Amoebiasis_Homo sapiens_hsa051460.83005640
118ECM-receptor interaction_Homo sapiens_hsa045120.82737377
119Cocaine addiction_Homo sapiens_hsa050300.82628526
120MAPK signaling pathway_Homo sapiens_hsa040100.82264799
121Renin-angiotensin system_Homo sapiens_hsa046140.81000633
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78928004
123Salmonella infection_Homo sapiens_hsa051320.78219461
124* Endocytosis_Homo sapiens_hsa041440.77205020
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76596800
126Vibrio cholerae infection_Homo sapiens_hsa051100.75476433
127Renin secretion_Homo sapiens_hsa049240.75410731
128Thyroid cancer_Homo sapiens_hsa052160.75182924
129* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74307976
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73879229
131Non-small cell lung cancer_Homo sapiens_hsa052230.73104461
132Renal cell carcinoma_Homo sapiens_hsa052110.72453642
133Dilated cardiomyopathy_Homo sapiens_hsa054140.72194252
134Jak-STAT signaling pathway_Homo sapiens_hsa046300.72085094
135Insulin signaling pathway_Homo sapiens_hsa049100.72009501
136Circadian rhythm_Homo sapiens_hsa047100.71120131
137* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70550159
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.69918034
139Nitrogen metabolism_Homo sapiens_hsa009100.69715502
140PPAR signaling pathway_Homo sapiens_hsa033200.65825734
141cAMP signaling pathway_Homo sapiens_hsa040240.65330263
142Melanoma_Homo sapiens_hsa052180.65235448
143Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64851281
144Ras signaling pathway_Homo sapiens_hsa040140.64369842
145Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63271808
146Pancreatic cancer_Homo sapiens_hsa052120.62689327
147Prion diseases_Homo sapiens_hsa050200.62116087
148Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61164110
149* Prolactin signaling pathway_Homo sapiens_hsa049170.60967873
150Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59673699
151Leukocyte transendothelial migration_Homo sapiens_hsa046700.59657913
152Thyroid hormone synthesis_Homo sapiens_hsa049180.58463108
153Pathways in cancer_Homo sapiens_hsa052000.58102509
154* Shigellosis_Homo sapiens_hsa051310.58004736
155Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57694993
156Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57203059
157HIF-1 signaling pathway_Homo sapiens_hsa040660.56635368
158T cell receptor signaling pathway_Homo sapiens_hsa046600.55411002
159Epstein-Barr virus infection_Homo sapiens_hsa051690.51572223
160Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48004256
161Insulin resistance_Homo sapiens_hsa049310.45718800
162Sulfur metabolism_Homo sapiens_hsa009200.43176147
163Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41751682
164Collecting duct acid secretion_Homo sapiens_hsa049660.40271038
165Cyanoamino acid metabolism_Homo sapiens_hsa004600.37784843
166HTLV-I infection_Homo sapiens_hsa051660.35585334
167Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35324369
168Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34221267
169Vitamin digestion and absorption_Homo sapiens_hsa049770.33831182
170Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27756986

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