SRCAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)4.80712943
2histone H3-K4 methylation (GO:0051568)4.63537243
3mitotic sister chromatid cohesion (GO:0007064)4.63307735
4histone H3-K4 trimethylation (GO:0080182)4.60960099
5cytoplasmic mRNA processing body assembly (GO:0033962)4.39000694
6nuclear pore complex assembly (GO:0051292)4.35022246
7negative regulation of erythrocyte differentiation (GO:0045647)4.28883483
8regulation of histone H3-K27 methylation (GO:0061085)4.09615678
9glucocorticoid receptor signaling pathway (GO:0042921)3.90238188
10NLS-bearing protein import into nucleus (GO:0006607)3.89207534
11nuclear pore organization (GO:0006999)3.77732420
12regulation of RNA export from nucleus (GO:0046831)3.70690991
13histone lysine methylation (GO:0034968)3.69199484
14regulation of NFAT protein import into nucleus (GO:0051532)3.54002210
15peptidyl-lysine trimethylation (GO:0018023)3.52329002
16histone H3-K36 demethylation (GO:0070544)3.49209494
17mannose metabolic process (GO:0006013)3.45984121
18adherens junction assembly (GO:0034333)3.45610461
19positive regulation of gene expression, epigenetic (GO:0045815)3.44576351
20positive regulation of histone deacetylation (GO:0031065)3.41709740
21negative regulation of histone methylation (GO:0031061)3.39742783
22negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.31668533
23negative regulation of translation, ncRNA-mediated (GO:0040033)3.31668533
24regulation of translation, ncRNA-mediated (GO:0045974)3.31668533
25corticosteroid receptor signaling pathway (GO:0031958)3.29591050
26cell-substrate adherens junction assembly (GO:0007045)3.28353082
27focal adhesion assembly (GO:0048041)3.28353082
28negative regulation of myotube differentiation (GO:0010832)3.25970907
29apoptotic process involved in morphogenesis (GO:0060561)3.21699020
30intracellular estrogen receptor signaling pathway (GO:0030520)3.20568368
31stress granule assembly (GO:0034063)3.18770735
32histone H4-K16 acetylation (GO:0043984)3.18042318
33pore complex assembly (GO:0046931)3.14610859
34positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.14055469
35embryonic retina morphogenesis in camera-type eye (GO:0060059)3.12607991
36positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.12424356
37regulation of nucleobase-containing compound transport (GO:0032239)3.10313686
38regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.09903167
39embryonic process involved in female pregnancy (GO:0060136)3.08513315
403-UTR-mediated mRNA stabilization (GO:0070935)3.07500106
41histone methylation (GO:0016571)3.06923656
42thymic T cell selection (GO:0045061)3.04336487
43insulin-like growth factor receptor signaling pathway (GO:0048009)3.04161653
44positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.02103300
45peptidyl-lysine dimethylation (GO:0018027)3.02042590
46histone H4-K12 acetylation (GO:0043983)3.01907703
47regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.00717358
48positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.00717358
49cellular response to epidermal growth factor stimulus (GO:0071364)2.93914802
50spliceosomal tri-snRNP complex assembly (GO:0000244)2.93824283
51histone lysine demethylation (GO:0070076)2.91931861
52activation of Rac GTPase activity (GO:0032863)2.91663661
53peptidyl-lysine methylation (GO:0018022)2.90812956
54histone H3-K9 methylation (GO:0051567)2.90583371
55positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.87776969
56regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.87776969
57cytoskeletal anchoring at plasma membrane (GO:0007016)2.86833024
58histone H3-K9 demethylation (GO:0033169)2.85124046
59heart morphogenesis (GO:0003007)2.85086199
60positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.83931288
61paraxial mesoderm development (GO:0048339)2.81907107
62RNA stabilization (GO:0043489)2.80784336
63mRNA stabilization (GO:0048255)2.80784336
64response to laminar fluid shear stress (GO:0034616)2.80316497
65regulation of mammary gland epithelial cell proliferation (GO:0033599)2.80084127
66positive regulation of RNA splicing (GO:0033120)2.79245986
67regulation of glucose import in response to insulin stimulus (GO:2001273)2.79019763
68positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.78920475
69histone H3-K9 modification (GO:0061647)2.77449959
70gene silencing (GO:0016458)2.74855630
71heterochromatin organization (GO:0070828)2.73233191
72histone demethylation (GO:0016577)2.72698689
73regulation of ARF protein signal transduction (GO:0032012)2.72639373
74regulation of DNA endoreduplication (GO:0032875)2.72463279
75histone H4 acetylation (GO:0043967)2.72308223
76nucleosome disassembly (GO:0006337)2.72248929
77protein-DNA complex disassembly (GO:0032986)2.72248929
78response to epidermal growth factor (GO:0070849)2.71482697
79histone H4-K8 acetylation (GO:0043982)2.70043776
80histone H4-K5 acetylation (GO:0043981)2.70043776
81regulation of chromatin binding (GO:0035561)2.69388064
82negative regulation of fatty acid transport (GO:2000192)2.67010748
83dosage compensation (GO:0007549)2.66304143
84cell-substrate junction assembly (GO:0007044)2.65756708
85chromatin silencing (GO:0006342)2.64981764
86negative regulation of viral release from host cell (GO:1902187)2.64872522
87regulation of ARF GTPase activity (GO:0032312)2.62467142
88trophectodermal cell differentiation (GO:0001829)2.62311423
89semaphorin-plexin signaling pathway (GO:0071526)2.61258183
90positive regulation of CREB transcription factor activity (GO:0032793)2.60052429
91regulation of sister chromatid cohesion (GO:0007063)2.58813883
92hippo signaling (GO:0035329)2.58359753
93embryonic eye morphogenesis (GO:0048048)2.56999675
94gene silencing by RNA (GO:0031047)2.55154344
95response to muramyl dipeptide (GO:0032495)2.54676738
96positive regulation of mRNA catabolic process (GO:0061014)2.54048448
97mitotic chromosome condensation (GO:0007076)2.53493457
98histone H4 deacetylation (GO:0070933)2.51771087
99regulation of mRNA catabolic process (GO:0061013)2.51557511
100regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.51418677
101regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.49533077
102regulation of translational fidelity (GO:0006450)2.49062433
103negative thymic T cell selection (GO:0045060)2.48755202
104N-terminal protein amino acid acetylation (GO:0006474)2.47426822
105protein demethylation (GO:0006482)2.44937081
106protein dealkylation (GO:0008214)2.44937081
107T cell selection (GO:0045058)2.44753356
108regulation of histone H3-K4 methylation (GO:0051569)2.44475000
109negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.44033959
110positive thymic T cell selection (GO:0045059)2.43371158
111regulation of gamma-delta T cell differentiation (GO:0045586)2.42271008
112positive regulation of protein deacetylation (GO:0090312)2.41418252
113negative regulation of gene expression, epigenetic (GO:0045814)2.40969867
114epithelial cell differentiation involved in prostate gland development (GO:0060742)2.40662418
115regulation of cholesterol homeostasis (GO:2000188)2.38291615
116regulation of histone H3-K9 methylation (GO:0051570)2.37517605
117atrioventricular valve morphogenesis (GO:0003181)2.36993414
118neural tube development (GO:0021915)2.35280707
119cellular response to virus (GO:0098586)2.35183581
120positive regulation of blood vessel endothelial cell migration (GO:0043536)2.34949029
121positive regulation by host of viral transcription (GO:0043923)2.33770048
122negative regulation of striated muscle cell differentiation (GO:0051154)2.33558296
123histone mRNA catabolic process (GO:0071044)2.31899721
124planar cell polarity pathway involved in neural tube closure (GO:0090179)2.31888933
125* histone acetylation (GO:0016573)2.31271708
126regulation of DNA damage checkpoint (GO:2000001)2.30314921
127neural tube closure (GO:0001843)2.28649902
128regulation of protein polyubiquitination (GO:1902914)2.27428638
129* internal peptidyl-lysine acetylation (GO:0018393)2.27330996
130regulation of histone deacetylation (GO:0031063)2.27294105
131regulation of protein deacetylation (GO:0090311)2.27223899
132peptidyl-threonine phosphorylation (GO:0018107)2.27114142
133regulation of histone methylation (GO:0031060)2.26579833
134positive regulation of gamma-delta T cell activation (GO:0046645)2.26167364
135interkinetic nuclear migration (GO:0022027)2.25723519
136negative regulation of cell size (GO:0045792)2.23656671
137tube closure (GO:0060606)2.23575847
138mitotic nuclear envelope disassembly (GO:0007077)2.23203072
139negative regulation of histone modification (GO:0031057)2.22853856
140positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.22777727
141positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.22777727
142positive regulation of mitotic sister chromatid separation (GO:1901970)2.22777727
143regulation of gamma-delta T cell activation (GO:0046643)2.22111560
144retrograde transport, vesicle recycling within Golgi (GO:0000301)2.20279085
145embryonic camera-type eye morphogenesis (GO:0048596)2.20250430
146establishment of nucleus localization (GO:0040023)2.20122608

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.59818436
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.10310880
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.90505745
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.83574403
5MYC_22102868_ChIP-Seq_BL_Human3.52105520
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.95765511
7TCF7_22412390_ChIP-Seq_EML_Mouse2.60765304
8KDM2B_26808549_Chip-Seq_DND41_Human2.47066211
9* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.41589696
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.39470064
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.36682122
12SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.34041116
13* DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.32312399
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.22199270
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.20330326
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.17614348
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16664133
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.11891625
19VDR_21846776_ChIP-Seq_THP-1_Human2.08307241
20ZFP281_27345836_Chip-Seq_ESCs_Mouse2.06891295
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.06727603
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.06393379
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.05525015
24TP63_17297297_ChIP-ChIP_HaCaT_Human2.03744004
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.02011441
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.98456020
27* KDM2B_26808549_Chip-Seq_JURKAT_Human1.87817869
28* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.74809048
29EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.73038879
30CIITA_25753668_ChIP-Seq_RAJI_Human1.70916909
31KDM2B_26808549_Chip-Seq_K562_Human1.70799687
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.66455892
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.64400812
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.63450013
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62130043
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.59619039
37PKCTHETA_26484144_Chip-Seq_BREAST_Human1.58458223
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57184764
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.56511016
40MAF_26560356_Chip-Seq_TH2_Human1.55219653
41SCL_19346495_ChIP-Seq_HPC-7_Human1.52734970
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.51212806
43* UTX_26944678_Chip-Seq_JUKART_Human1.50726330
44SPI1_23127762_ChIP-Seq_K562_Human1.48230048
45P300_27058665_Chip-Seq_ZR-75-30cells_Human1.47063792
46ISL1_27105846_Chip-Seq_CPCs_Mouse1.46537411
47HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.46344518
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46108161
49KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.45818916
50SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.45471595
51NFIB_24661679_ChIP-Seq_LUNG_Mouse1.44961482
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44782972
53SMC4_20622854_ChIP-Seq_HELA_Human1.43278719
54RUNX1_22412390_ChIP-Seq_EML_Mouse1.41278162
55CTCF_27219007_Chip-Seq_ERYTHROID_Human1.40661344
56MAF_26560356_Chip-Seq_TH1_Human1.40382467
57RUNX_20019798_ChIP-Seq_JUKART_Human1.38509026
58CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.37670087
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37038426
60* P68_20966046_ChIP-Seq_HELA_Human1.36256075
61DROSHA_22980978_ChIP-Seq_HELA_Human1.35811681
62CTNNB1_20460455_ChIP-Seq_HCT116_Human1.34221964
63* ELK3_25401928_ChIP-Seq_HUVEC_Human1.33878946
64E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30598190
65MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.25041945
66* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23924567
67E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22748649
68SA1_27219007_Chip-Seq_ERYTHROID_Human1.22180257
69UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20617504
70CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19324232
71VDR_24763502_ChIP-Seq_THP-1_Human1.19192351
72NCOR1_26117541_ChIP-Seq_K562_Human1.18332023
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.18023960
74* MYB_26560356_Chip-Seq_TH1_Human1.16063926
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15488962
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14202666
77CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13544959
78* FOXA2_19822575_ChIP-Seq_HepG2_Human1.12783853
79WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12084244
80NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10488703
81* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10412947
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10255353
83TP53_22127205_ChIP-Seq_IMR90_Human1.10252099
84GATA1_19941826_ChIP-Seq_K562_Human1.10200714
85CLOCK_20551151_ChIP-Seq_293T_Human1.09999841
86STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09666437
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08558587
88* CREB1_26743006_Chip-Seq_LNCaP_Human1.08313603
89TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08272268
90ZNF263_19887448_ChIP-Seq_K562_Human1.07810734
91SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07765390
92MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.07102164
93CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06426671
94MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05363417
95TP53_16413492_ChIP-PET_HCT116_Human1.04720166
96MYB_21317192_ChIP-Seq_ERMYB_Mouse1.04474905
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04417231
98TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03828831
99GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03669468
100UBF1/2_26484160_Chip-Seq_HMECs_Human1.03645133
101TET1_21451524_ChIP-Seq_MESCs_Mouse1.02956729
102* RUNX1_27514584_Chip-Seq_MCF-7_Human1.02397695
103ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02127194
104SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02104728
105CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01810357
106TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01710258
107ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01659848
108TBX20_22328084_ChIP-Seq_HEART_Mouse1.01233562
109TBX20_22080862_ChIP-Seq_HEART_Mouse1.01233562
110TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.01143464
111ATF3_27146783_Chip-Seq_COLON_Human1.00239483
112BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98143533
113FOXO3_23340844_ChIP-Seq_DLD1_Human0.97609863
114* GATA6_25053715_ChIP-Seq_YYC3_Human0.97607662
115ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97067432
116BRD4_25478319_ChIP-Seq_HGPS_Human0.96935495
117AHR_22903824_ChIP-Seq_MCF-7_Human0.96865090
118TCF4_18268006_ChIP-ChIP_LS174T_Human0.96672196
119SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96300519
120ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96063846
121SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96057204
122NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95577827
123RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94586586
124MYB_26560356_Chip-Seq_TH2_Human0.94537050
125DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94364901
126NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93245564
127DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93181631
128GATA1_19941827_ChIP-Seq_MEL_Mouse0.93130822
129RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93004190
130ELF1_20517297_ChIP-Seq_JURKAT_Human0.91624442
131TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91019287
132* CHD1_26751641_Chip-Seq_LNCaP_Human0.90688611
133LXR_22292898_ChIP-Seq_THP-1_Human0.90544937
134FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.90330978
135CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90301133
136* RACK7_27058665_Chip-Seq_MCF-7_Human0.89596800
137BRD4_27068464_Chip-Seq_AML-cells_Mouse0.89557761
138* AR_19668381_ChIP-Seq_PC3_Human0.88302055
139ESR1_20079471_ChIP-ChIP_T-47D_Human0.87039638

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.69222750
2MP0005076_abnormal_cell_differentiation3.59443715
3MP0003705_abnormal_hypodermis_morpholog2.78424933
4MP0010352_gastrointestinal_tract_polyps2.76129596
5MP0005451_abnormal_body_composition2.69245419
6MP0009278_abnormal_bone_marrow2.64412448
7MP0008961_abnormal_basal_metabolism2.48755845
8MP0005409_darkened_coat_color2.43955651
9MP0003300_gastrointestinal_ulcer2.23398852
10MP0002249_abnormal_larynx_morphology2.23383251
11MP0002009_preneoplasia2.11076804
12MP0008057_abnormal_DNA_replication2.09653301
13MP0002396_abnormal_hematopoietic_system2.09145780
14MP0004808_abnormal_hematopoietic_stem1.95703088
15MP0000733_abnormal_muscle_development1.92994277
16MP0010307_abnormal_tumor_latency1.90588143
17MP0001348_abnormal_lacrimal_gland1.88414884
18MP0003045_fibrosis1.81067417
19MP0003787_abnormal_imprinting1.72126923
20MP0003890_abnormal_embryonic-extraembry1.67736948
21MP0005670_abnormal_white_adipose1.67588372
22MP0004858_abnormal_nervous_system1.67514167
23MP0004264_abnormal_extraembryonic_tissu1.66556811
24MP0003984_embryonic_growth_retardation1.66094640
25MP0008877_abnormal_DNA_methylation1.65921927
26MP0002088_abnormal_embryonic_growth/wei1.63446691
27MP0000678_abnormal_parathyroid_gland1.62919318
28MP0004197_abnormal_fetal_growth/weight/1.62834575
29MP0003121_genomic_imprinting1.58876212
30MP0004233_abnormal_muscle_weight1.58644016
31MP0003436_decreased_susceptibility_to1.57948440
32MP0005380_embryogenesis_phenotype1.57229317
33MP0001672_abnormal_embryogenesis/_devel1.57229317
34MP0003111_abnormal_nucleus_morphology1.55802997
35MP0002084_abnormal_developmental_patter1.54375624
36MP0003935_abnormal_craniofacial_develop1.48924840
37MP0002166_altered_tumor_susceptibility1.48458870
38MP0003115_abnormal_respiratory_system1.46153827
39MP0010094_abnormal_chromosome_stability1.44552099
40MP0002925_abnormal_cardiovascular_devel1.43750990
41MP0004947_skin_inflammation1.43434189
42MP0002086_abnormal_extraembryonic_tissu1.43405065
43MP0010630_abnormal_cardiac_muscle1.42390746
44MP0009703_decreased_birth_body1.41353400
45MP0000428_abnormal_craniofacial_morphol1.40929525
46MP0001849_ear_inflammation1.40852427
47MP0000350_abnormal_cell_proliferation1.38844921
48MP0010030_abnormal_orbit_morphology1.36952973
49MP0002085_abnormal_embryonic_tissue1.36621420
50MP0008260_abnormal_autophagy1.35770326
51MP0004381_abnormal_hair_follicle1.35068613
52MP0001730_embryonic_growth_arrest1.34477348
53MP0001873_stomach_inflammation1.33763776
54MP0003453_abnormal_keratinocyte_physiol1.32561828
55MP0003077_abnormal_cell_cycle1.31054426
56MP0009672_abnormal_birth_weight1.30605362
57MP0005397_hematopoietic_system_phenotyp1.30248015
58MP0001545_abnormal_hematopoietic_system1.30248015
59MP0003566_abnormal_cell_adhesion1.30126984
60MP0005058_abnormal_lysosome_morphology1.29833910
61MP0001293_anophthalmia1.28472001
62MP0002653_abnormal_ependyma_morphology1.28293671
63MP0000703_abnormal_thymus_morphology1.20961232
64MP0001697_abnormal_embryo_size1.19621729
65MP0001915_intracranial_hemorrhage1.18445646
66MP0004185_abnormal_adipocyte_glucose1.18376834
67MP0003091_abnormal_cell_migration1.18277308
68MP0005248_abnormal_Harderian_gland1.17141171
69MP0000266_abnormal_heart_morphology1.15991285
70MP0009053_abnormal_anal_canal1.15196465
71MP0005187_abnormal_penis_morphology1.14514151
72MP0003567_abnormal_fetal_cardiomyocyte1.12679736
73MP0009333_abnormal_splenocyte_physiolog1.11528623
74MP0000003_abnormal_adipose_tissue1.09867531
75MP0002697_abnormal_eye_size1.08279166
76MP0000432_abnormal_head_morphology1.04258096
77MP0002006_tumorigenesis1.04017422
78MP0005375_adipose_tissue_phenotype1.02056974
79MP0002092_abnormal_eye_morphology1.01423275
80MP0005666_abnormal_adipose_tissue0.98241963
81MP0009115_abnormal_fat_cell0.97651538
82MP0002970_abnormal_white_adipose0.96163503
83MP0003283_abnormal_digestive_organ0.94775681
84MP0010234_abnormal_vibrissa_follicle0.94773752
85MP0003122_maternal_imprinting0.94677632
86MP0000759_abnormal_skeletal_muscle0.93911713
87MP0003303_peritoneal_inflammation0.93273378
88MP0002080_prenatal_lethality0.92315470
89MP0001346_abnormal_lacrimal_gland0.92071779
90MP0002089_abnormal_postnatal_growth/wei0.91864178
91MP0000685_abnormal_immune_system0.91529029
92MP0004087_abnormal_muscle_fiber0.91297828
93MP0000383_abnormal_hair_follicle0.90941860
94MP0003385_abnormal_body_wall0.90322490
95MP0001784_abnormal_fluid_regulation0.89509021
96MP0005023_abnormal_wound_healing0.88293856
97MP0002722_abnormal_immune_system0.88244142
98MP0003763_abnormal_thymus_physiology0.87939990
99MP0008438_abnormal_cutaneous_collagen0.87531586
100MP0002928_abnormal_bile_duct0.87476249
101MP0002796_impaired_skin_barrier0.87181073
102MP0002998_abnormal_bone_remodeling0.86484539
103MP0005310_abnormal_salivary_gland0.86279971
104MP0000537_abnormal_urethra_morphology0.84568597
105MP0002405_respiratory_system_inflammati0.84509298
106MP0009931_abnormal_skin_appearance0.84275230
107MP0000566_synostosis0.82648497
108MP0000371_diluted_coat_color0.82572233
109MP0004510_myositis0.80603055
110MP0002116_abnormal_craniofacial_bone0.79784145
111MP0002060_abnormal_skin_morphology0.78608683
112MP0005621_abnormal_cell_physiology0.78458751
113MP0008770_decreased_survivor_rate0.78433758
114MP0005623_abnormal_meninges_morphology0.78366822
115MP0001800_abnormal_humoral_immune0.78053827
116MP0002108_abnormal_muscle_morphology0.77912679
117MP0010368_abnormal_lymphatic_system0.77728949
118MP0003861_abnormal_nervous_system0.77671549
119MP0002398_abnormal_bone_marrow0.77622482
120MP0006138_congestive_heart_failure0.77538421
121MP0003119_abnormal_digestive_system0.77216455
122MP0002098_abnormal_vibrissa_morphology0.77121909
123MP0000716_abnormal_immune_system0.76427067
124MP0001299_abnormal_eye_distance/0.76116267
125MP0000858_altered_metastatic_potential0.76063701
126MP0003172_abnormal_lysosome_physiology0.75991641
127MP0003828_pulmonary_edema0.75634284
128MP0003755_abnormal_palate_morphology0.75441383
129MP0002429_abnormal_blood_cell0.75123152
130MP0005384_cellular_phenotype0.73823293
131MP0000747_muscle_weakness0.73791917
132MP0010678_abnormal_skin_adnexa0.73529126
133MP0000751_myopathy0.73349650
134MP0009780_abnormal_chondrocyte_physiolo0.73251877
135MP0000767_abnormal_smooth_muscle0.73212817
136MP0005257_abnormal_intraocular_pressure0.72941528
137MP0003279_aneurysm0.71586339
138MP0008007_abnormal_cellular_replicative0.70050445
139MP0002877_abnormal_melanocyte_morpholog0.68810724

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.93516451
2Obstructive sleep apnea (HP:0002870)4.15797305
3Broad face (HP:0000283)3.81902741
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.76519982
5Short 4th metacarpal (HP:0010044)3.76519982
6Macroorchidism (HP:0000053)3.48791084
7Volvulus (HP:0002580)3.21651635
8Narrow palate (HP:0000189)3.10080526
9Hyperacusis (HP:0010780)3.05710112
10* Long eyelashes (HP:0000527)3.05668085
11Abnormality of the 4th metacarpal (HP:0010012)2.77973974
12Anal stenosis (HP:0002025)2.70167879
13Heterotopia (HP:0002282)2.64528540
14Cerebral aneurysm (HP:0004944)2.59069472
15Increased nuchal translucency (HP:0010880)2.55512116
16Obsessive-compulsive behavior (HP:0000722)2.54076446
17Renovascular hypertension (HP:0100817)2.50519290
18Elfin facies (HP:0004428)2.46465422
19Flat acetabular roof (HP:0003180)2.45108873
20Astrocytoma (HP:0009592)2.45087656
21Abnormality of the astrocytes (HP:0100707)2.45087656
22Shallow orbits (HP:0000586)2.42613339
23Persistence of primary teeth (HP:0006335)2.39094363
24Broad thumb (HP:0011304)2.37781822
25Renal duplication (HP:0000075)2.33073902
26Truncal obesity (HP:0001956)2.31428477
27Depressed nasal tip (HP:0000437)2.27618420
28Lip pit (HP:0100267)2.25950310
29Ependymoma (HP:0002888)2.24399198
30Neoplasm of the oral cavity (HP:0100649)2.23866757
31Abnormality of the nasal septum (HP:0000419)2.23388927
32Ectopic kidney (HP:0000086)2.20306833
33Distal lower limb amyotrophy (HP:0008944)2.18886269
34Supernumerary ribs (HP:0005815)2.18852523
35Genetic anticipation (HP:0003743)2.15677827
36Glioma (HP:0009733)2.13807855
37Midline defect of the nose (HP:0004122)2.10810412
38Neoplasm of the heart (HP:0100544)2.09547429
39Abnormality of the phalanges of the hallux (HP:0010057)2.07624034
40* Trigonocephaly (HP:0000243)2.06960437
41Asymmetry of the thorax (HP:0001555)2.06389798
42Intestinal fistula (HP:0100819)2.04868266
43Skin tags (HP:0010609)2.03348611
44Dysmetric saccades (HP:0000641)2.02220461
45Advanced eruption of teeth (HP:0006288)2.02165594
46Limited elbow extension (HP:0001377)2.01968946
47Protrusio acetabuli (HP:0003179)2.00625853
48Thick eyebrow (HP:0000574)1.97613070
49Absent frontal sinuses (HP:0002688)1.97277334
50Thin bony cortex (HP:0002753)1.97155079
51Neonatal hypoglycemia (HP:0001998)1.95287616
52Aortic aneurysm (HP:0004942)1.94585549
53Deep philtrum (HP:0002002)1.94313110
54Broad palm (HP:0001169)1.94191875
55Self-mutilation (HP:0000742)1.94166446
56Abnormality of the aortic arch (HP:0012303)1.91872903
57Increased connective tissue (HP:0009025)1.91814001
58Sparse lateral eyebrow (HP:0005338)1.91704519
59Germ cell neoplasia (HP:0100728)1.91216326
60Broad phalanges of the hand (HP:0009768)1.90233413
61Centrally nucleated skeletal muscle fibers (HP:0003687)1.90150807
62Hypoplastic ischia (HP:0003175)1.89746225
63Abnormality of the thoracic spine (HP:0100711)1.89520093
64Low anterior hairline (HP:0000294)1.88595064
65Deviation of the thumb (HP:0009603)1.88129972
66Hemorrhage of the eye (HP:0011885)1.87797271
67Skull defect (HP:0001362)1.87445360
68Vertebral arch anomaly (HP:0008438)1.87008608
69Proximal placement of thumb (HP:0009623)1.86964858
70Leiomyosarcoma (HP:0100243)1.86880987
71Uterine leiomyosarcoma (HP:0002891)1.86880987
72Colitis (HP:0002583)1.86498842
73Aneurysm (HP:0002617)1.86443231
74Overriding aorta (HP:0002623)1.85780181
75Large earlobe (HP:0009748)1.84888735
76Pseudobulbar signs (HP:0002200)1.83921642
77Abnormal number of incisors (HP:0011064)1.83529543
78Abnormality of the distal phalanx of the thumb (HP:0009617)1.83271070
79Transitional cell carcinoma of the bladder (HP:0006740)1.83110849
80Pointed chin (HP:0000307)1.82983404
81Cutis marmorata (HP:0000965)1.82931028
82Precocious puberty (HP:0000826)1.82925252
83Acute lymphatic leukemia (HP:0006721)1.82802433
84Bronchomalacia (HP:0002780)1.82689558
85Flat cornea (HP:0007720)1.80779459
86Spinal cord lesions (HP:0100561)1.79297492
87Syringomyelia (HP:0003396)1.79297492
88Bowel diverticulosis (HP:0005222)1.78127540
89Premature skin wrinkling (HP:0100678)1.77393227
90Hypoplasia of the maxilla (HP:0000327)1.76985617
91Supernumerary bones of the axial skeleton (HP:0009144)1.76852586
92Septate vagina (HP:0001153)1.76150457
93Broad finger (HP:0001500)1.76091383
94Long palpebral fissure (HP:0000637)1.75600214
95Dislocated radial head (HP:0003083)1.75279667
96Malignant gastrointestinal tract tumors (HP:0006749)1.75110953
97Gastrointestinal carcinoma (HP:0002672)1.75110953
98Ureteral obstruction (HP:0006000)1.74787709
99Hypoplastic labia majora (HP:0000059)1.74347482
100Patellar dislocation (HP:0002999)1.74167194
101Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.73855622
102Medulloblastoma (HP:0002885)1.73284357
103Abnormality of the humeroradial joint (HP:0100744)1.73054341
104Disproportionate tall stature (HP:0001519)1.72536310
105Oligodontia (HP:0000677)1.72108846
106Aqueductal stenosis (HP:0002410)1.71740325
107Abnormality of the diencephalon (HP:0010662)1.70521334
108Papillary thyroid carcinoma (HP:0002895)1.70290595
109Abnormality of the radial head (HP:0003995)1.69814332
110Laryngomalacia (HP:0001601)1.69041433
111* Prominent nose (HP:0000448)1.68880710
112Neoplasm of striated muscle (HP:0009728)1.68263091
113Sacral dimple (HP:0000960)1.67948873
114Mitral valve prolapse (HP:0001634)1.66657392
115Autoimmune thrombocytopenia (HP:0001973)1.66046652
116Bowel incontinence (HP:0002607)1.65687371
117Ankyloglossia (HP:0010296)1.65437702
118Short 5th finger (HP:0009237)1.65418978
119Deep palmar crease (HP:0006191)1.65235753
120Metaphyseal cupping (HP:0003021)1.64863249
121Broad metatarsal (HP:0001783)1.64576618
122Broad phalanx (HP:0006009)1.64443722
123Sandal gap (HP:0001852)1.63536556
124Segmental peripheral demyelination/remyelination (HP:0003481)1.61427515
125Thin ribs (HP:0000883)1.61142343
126Biconcave vertebral bodies (HP:0004586)1.61024135
127Ureteral stenosis (HP:0000071)1.59882344
128Insomnia (HP:0100785)1.59775133
129Bladder carcinoma (HP:0002862)1.59679153
130Bladder neoplasm (HP:0009725)1.59679153
131Short phalanx of the thumb (HP:0009660)1.59547105
132Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.59444341
133Abnormality of the parietal bone (HP:0002696)1.59378010
134Spina bifida occulta (HP:0003298)1.59320679
135Ulnar bowing (HP:0003031)1.58934492
136Onion bulb formation (HP:0003383)1.58139528
137Preauricular skin tag (HP:0000384)1.57905749
138Deep venous thrombosis (HP:0002625)1.57618445
139Lower limb amyotrophy (HP:0007210)1.56877317
140High anterior hairline (HP:0009890)1.56665764
141Cellulitis (HP:0100658)1.53735556
142Natal tooth (HP:0000695)1.53119906
143Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.53049031
144Gastrointestinal inflammation (HP:0004386)1.52854384
145Mitral regurgitation (HP:0001653)1.52415477
146Thoracic kyphosis (HP:0002942)1.51535309
147Increased variability in muscle fiber diameter (HP:0003557)1.51498057
148Abnormality of oral frenula (HP:0000190)1.50854806
149Increased IgE level (HP:0003212)1.50086349
150Abnormal large intestine physiology (HP:0012700)1.49289996
151Abnormality of chromosome segregation (HP:0002916)1.49263176
152Cervical subluxation (HP:0003308)1.49094804
153Genu recurvatum (HP:0002816)1.48587817
154Slow saccadic eye movements (HP:0000514)1.47064553
155Emphysema (HP:0002097)1.43637183

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.52169124
2BRD43.48578519
3CAMK1D3.32293618
4SMG13.29028371
5CAMK1G3.27074338
6PRPF4B3.09507542
7LATS12.86659951
8MAP3K102.84102793
9EEF2K2.32571616
10ICK2.13235665
11RIPK12.11600898
12SIK12.08543290
13SIK21.85862662
14TRIB31.82650600
15MTOR1.80775424
16DMPK1.58705080
17CDC71.51202924
18MAP4K11.43516666
19NEK21.42631404
20PKN21.39203568
21TTN1.34793077
22TAOK11.34778193
23ERN11.32082389
24IRAK31.31324899
25PDGFRA1.23789802
26MAP3K131.21387594
27FGFR31.20080242
28CDK61.18319163
29MAP3K71.17810569
30PTK61.16594939
31CDK91.16555921
32STK31.15150775
33SGK31.11172268
34SIK31.08361580
35CDC42BPA1.07645746
36PDGFRB1.05776882
37MARK21.03692389
38RIPK41.03560511
39ALK1.03478910
40MAPK111.01267772
41CDK41.01064944
42MAP2K31.00753371
43FGFR20.97353461
44CHUK0.95683991
45EPHA30.95072158
46TNK20.94307327
47ATR0.94189583
48STK380.88051965
49WNK10.87717383
50CAMK40.86682635
51CHEK10.86322075
52KSR20.83965035
53BMX0.81000951
54FGFR10.80573803
55MAP3K140.79850652
56STK100.79463809
57ATM0.77860927
58ERBB20.77709152
59JAK10.76370785
60PRKD20.76307017
61CDK70.75398677
62RPS6KA20.74229079
63ZAP700.72219000
64TYRO30.71820977
65PRKD30.71679350
66FGFR40.71532453
67PRKCH0.71508701
68MKNK20.68948647
69CDK20.68253574
70AKT30.67848589
71RPS6KC10.65286145
72RPS6KL10.65286145
73PDPK10.64979031
74TYK20.64390181
75SGK20.63299501
76MAPK140.63281862
77LATS20.62132148
78MAPK100.60730804
79JAK30.60585440
80STK40.60011145
81MAP3K10.59952492
82TAOK30.59860225
83PTK20.57686943
84CAMKK10.57585670
85HCK0.57551448
86GSK3B0.57291332
87MST1R0.55980756
88CHEK20.55915657
89CDK10.54004408
90PRKAA10.53737779
91MAPK10.53674798
92DDR20.53096265
93RPS6KA60.52632456
94BLK0.51784551
95PAK20.51402889
96MAPK80.51196217
97MAP3K30.50569049
98TAOK20.50545387
99BTK0.48456874
100PDK10.48445402
101MELK0.47875943
102PRKDC0.47762243
103EPHB10.47229865
104TTK0.47186195
105HIPK20.46922654
106SGK10.46918906
107CSNK1D0.46135152
108CSF1R0.45335707
109AKT10.44990778
110PRKAA20.44864165
111MAP2K20.44381422
112MAPK70.44327395
113RET0.44244015
114PAK40.41933522
115IRAK20.41588537
116MAP3K80.40781599
117AKT20.39988459
118RPS6KA10.38409247
119INSRR0.38333213
120MAP3K60.38310802
121EPHA20.38055100
122MAPK120.37821736
123IRAK40.37326274
124TRPM70.36644473
125NUAK10.36469941
126PNCK0.36456366
127KSR10.35536560
128ITK0.35374619
129RPS6KA30.35308821
130STK110.34974127
131TGFBR20.34501005
132RPS6KB20.32649624
133CSNK1E0.32573113
134MARK30.32499970
135PRKD10.32057802
136MAPK30.31742775

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysine degradation_Homo sapiens_hsa003102.81761380
2mTOR signaling pathway_Homo sapiens_hsa041501.78045902
3Notch signaling pathway_Homo sapiens_hsa043301.77023156
4Chronic myeloid leukemia_Homo sapiens_hsa052201.75812900
5Thyroid hormone signaling pathway_Homo sapiens_hsa049191.72335526
6Adherens junction_Homo sapiens_hsa045201.60881547
7MicroRNAs in cancer_Homo sapiens_hsa052061.55728900
8Type II diabetes mellitus_Homo sapiens_hsa049301.51197843
9Other glycan degradation_Homo sapiens_hsa005111.36938703
10Endometrial cancer_Homo sapiens_hsa052131.34073942
11Dorso-ventral axis formation_Homo sapiens_hsa043201.33985412
12Basal cell carcinoma_Homo sapiens_hsa052171.32437562
13B cell receptor signaling pathway_Homo sapiens_hsa046621.31267220
14Non-small cell lung cancer_Homo sapiens_hsa052231.29860157
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.29649906
16Colorectal cancer_Homo sapiens_hsa052101.27775477
17Acute myeloid leukemia_Homo sapiens_hsa052211.27025574
18Small cell lung cancer_Homo sapiens_hsa052221.25366677
19Viral myocarditis_Homo sapiens_hsa054161.24272245
20mRNA surveillance pathway_Homo sapiens_hsa030151.24051091
21Proteoglycans in cancer_Homo sapiens_hsa052051.22996440
22Pancreatic cancer_Homo sapiens_hsa052121.20840823
23Glioma_Homo sapiens_hsa052141.19289545
24Longevity regulating pathway - mammal_Homo sapiens_hsa042111.18332561
25Neurotrophin signaling pathway_Homo sapiens_hsa047221.14265313
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13432364
27Insulin resistance_Homo sapiens_hsa049311.12457182
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10849932
29Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.09845283
30Transcriptional misregulation in cancer_Homo sapiens_hsa052021.08997456
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07739740
32T cell receptor signaling pathway_Homo sapiens_hsa046601.06653386
33Prostate cancer_Homo sapiens_hsa052151.06588392
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.06276269
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06122858
36HTLV-I infection_Homo sapiens_hsa051661.03912275
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.03759446
38Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01927907
39Dilated cardiomyopathy_Homo sapiens_hsa054141.01840752
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99842682
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99036285
42Focal adhesion_Homo sapiens_hsa045100.97856850
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96690644
44ErbB signaling pathway_Homo sapiens_hsa040120.96563522
45Hepatitis C_Homo sapiens_hsa051600.96317253
46Renal cell carcinoma_Homo sapiens_hsa052110.95668438
47Primary immunodeficiency_Homo sapiens_hsa053400.94649829
48Osteoclast differentiation_Homo sapiens_hsa043800.94055488
49Wnt signaling pathway_Homo sapiens_hsa043100.93512589
50Central carbon metabolism in cancer_Homo sapiens_hsa052300.93092953
51Hepatitis B_Homo sapiens_hsa051610.92528839
52Hippo signaling pathway_Homo sapiens_hsa043900.91481641
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90455964
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90245297
55Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.89561600
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.88977953
57FoxO signaling pathway_Homo sapiens_hsa040680.88104671
58Cell cycle_Homo sapiens_hsa041100.87853675
59Apoptosis_Homo sapiens_hsa042100.86863235
60Hedgehog signaling pathway_Homo sapiens_hsa043400.86721006
61Insulin signaling pathway_Homo sapiens_hsa049100.86630577
62Pathways in cancer_Homo sapiens_hsa052000.85154046
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.84068218
64Choline metabolism in cancer_Homo sapiens_hsa052310.83471633
65AMPK signaling pathway_Homo sapiens_hsa041520.82501072
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80326863
67Prolactin signaling pathway_Homo sapiens_hsa049170.80149567
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79657244
69TGF-beta signaling pathway_Homo sapiens_hsa043500.79595474
70Prion diseases_Homo sapiens_hsa050200.79233735
71Inositol phosphate metabolism_Homo sapiens_hsa005620.79203086
72VEGF signaling pathway_Homo sapiens_hsa043700.79143042
73Herpes simplex infection_Homo sapiens_hsa051680.79129431
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78814463
75Toxoplasmosis_Homo sapiens_hsa051450.78597729
76Estrogen signaling pathway_Homo sapiens_hsa049150.78552421
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.77743837
78MAPK signaling pathway_Homo sapiens_hsa040100.75835145
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75638445
80Platelet activation_Homo sapiens_hsa046110.75151635
81Viral carcinogenesis_Homo sapiens_hsa052030.74166635
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.72821395
83Rap1 signaling pathway_Homo sapiens_hsa040150.72711398
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.72556325
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.71682543
86HIF-1 signaling pathway_Homo sapiens_hsa040660.71540007
87Glucagon signaling pathway_Homo sapiens_hsa049220.71116392
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70818187
89Chemokine signaling pathway_Homo sapiens_hsa040620.68609850
90cAMP signaling pathway_Homo sapiens_hsa040240.65888166
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.65675679
92Influenza A_Homo sapiens_hsa051640.65534583
93ECM-receptor interaction_Homo sapiens_hsa045120.65054150
94Circadian rhythm_Homo sapiens_hsa047100.64634742
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.64364218
96Epstein-Barr virus infection_Homo sapiens_hsa051690.62608591
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.62436767
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.62274585
99Thyroid cancer_Homo sapiens_hsa052160.61898642
100TNF signaling pathway_Homo sapiens_hsa046680.61596680
101Measles_Homo sapiens_hsa051620.61543866
102Oxytocin signaling pathway_Homo sapiens_hsa049210.61439122
103GnRH signaling pathway_Homo sapiens_hsa049120.59696228
104Fructose and mannose metabolism_Homo sapiens_hsa000510.59045878
105Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57597549
106Long-term potentiation_Homo sapiens_hsa047200.57439808
107Leishmaniasis_Homo sapiens_hsa051400.56803518
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56449181
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56297319
110Melanogenesis_Homo sapiens_hsa049160.56177872
111Melanoma_Homo sapiens_hsa052180.55976840
112Fatty acid biosynthesis_Homo sapiens_hsa000610.55169371
113Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54455841
114Amoebiasis_Homo sapiens_hsa051460.54298728
115Bladder cancer_Homo sapiens_hsa052190.53631227
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53129262
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53043178
118Endocytosis_Homo sapiens_hsa041440.51327298
119Tuberculosis_Homo sapiens_hsa051520.49042457

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