SRCIN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.37091744
2locomotory exploration behavior (GO:0035641)6.03254623
3regulation of short-term neuronal synaptic plasticity (GO:0048172)6.02638980
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.77703817
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.55163951
6vocalization behavior (GO:0071625)5.51492733
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.17613010
8glutamate secretion (GO:0014047)5.13898866
9synaptic vesicle exocytosis (GO:0016079)5.09643993
10regulation of synaptic vesicle exocytosis (GO:2000300)4.92469963
11ionotropic glutamate receptor signaling pathway (GO:0035235)4.74282263
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.73511388
13regulation of glutamate receptor signaling pathway (GO:1900449)4.68899253
14neuronal action potential propagation (GO:0019227)4.64874119
15layer formation in cerebral cortex (GO:0021819)4.56554269
16protein localization to synapse (GO:0035418)4.55874219
17dendritic spine morphogenesis (GO:0060997)4.55107057
18neuron cell-cell adhesion (GO:0007158)4.54999855
19exploration behavior (GO:0035640)4.47736670
20regulation of neuronal synaptic plasticity (GO:0048168)4.44338005
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.41424237
22neurotransmitter secretion (GO:0007269)4.36781066
23gamma-aminobutyric acid transport (GO:0015812)4.36132611
24regulation of synaptic vesicle transport (GO:1902803)4.29952949
25synaptic transmission, glutamatergic (GO:0035249)4.26844898
26glutamate receptor signaling pathway (GO:0007215)4.16275788
27regulation of synapse structural plasticity (GO:0051823)4.14613156
28long-term memory (GO:0007616)3.96840343
29neurotransmitter-gated ion channel clustering (GO:0072578)3.96273073
30regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.94333253
31neuron-neuron synaptic transmission (GO:0007270)3.92741772
32positive regulation of membrane potential (GO:0045838)3.90832144
33cellular potassium ion homeostasis (GO:0030007)3.89136371
34regulation of synapse maturation (GO:0090128)3.84093241
35transmission of nerve impulse (GO:0019226)3.79523571
36regulation of excitatory postsynaptic membrane potential (GO:0060079)3.76898256
37proline transport (GO:0015824)3.72845883
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.72768456
39neuromuscular process controlling balance (GO:0050885)3.65667687
40sodium ion export (GO:0071436)3.65600238
41auditory behavior (GO:0031223)3.65458174
42potassium ion homeostasis (GO:0055075)3.63425540
43neurotransmitter transport (GO:0006836)3.61515520
44cerebellar granule cell differentiation (GO:0021707)3.58867090
45glycine transport (GO:0015816)3.57473098
46neuron recognition (GO:0008038)3.56487624
47regulation of postsynaptic membrane potential (GO:0060078)3.55749354
48L-amino acid import (GO:0043092)3.52235150
49regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.50141630
50amino acid import (GO:0043090)3.49922119
51regulation of synaptic plasticity (GO:0048167)3.48181171
52neuronal ion channel clustering (GO:0045161)3.47794850
53dendrite morphogenesis (GO:0048813)3.46924982
54cerebellar Purkinje cell differentiation (GO:0021702)3.43999824
55positive regulation of synapse maturation (GO:0090129)3.43141234
56regulation of neurotransmitter secretion (GO:0046928)3.41032782
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.37358092
58positive regulation of dendritic spine morphogenesis (GO:0061003)3.34904945
59neuromuscular synaptic transmission (GO:0007274)3.33182008
60axonal fasciculation (GO:0007413)3.31947612
61regulation of neurotransmitter levels (GO:0001505)3.31523766
62gamma-aminobutyric acid signaling pathway (GO:0007214)3.31134158
63synaptic vesicle endocytosis (GO:0048488)3.31022317
64* regulation of dendritic spine morphogenesis (GO:0061001)3.29588497
65postsynaptic membrane organization (GO:0001941)3.28376271
66activation of protein kinase A activity (GO:0034199)3.27993903
67positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.27397871
68response to auditory stimulus (GO:0010996)3.27310122
69dendritic spine organization (GO:0097061)3.25971465
70positive regulation of dendritic spine development (GO:0060999)3.25168139
71positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.24759703
72G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.21452985
73regulation of synaptic transmission, glutamatergic (GO:0051966)3.21323156
74cell differentiation in hindbrain (GO:0021533)3.21076748
75negative regulation of synaptic transmission, GABAergic (GO:0032229)3.20411627
76positive regulation of synaptic transmission, GABAergic (GO:0032230)3.19303347
77neuromuscular process controlling posture (GO:0050884)3.19156515
78adult walking behavior (GO:0007628)3.18698755
79prepulse inhibition (GO:0060134)3.18088823
80cellular sodium ion homeostasis (GO:0006883)3.16094726
81regulation of neurotransmitter transport (GO:0051588)3.15848852
82membrane hyperpolarization (GO:0060081)3.14301236
83regulation of vesicle fusion (GO:0031338)3.13609347
84long-term synaptic potentiation (GO:0060291)3.13445393
85presynaptic membrane organization (GO:0097090)3.13342055
86presynaptic membrane assembly (GO:0097105)3.12007235
87membrane depolarization (GO:0051899)3.10148523
88axon ensheathment in central nervous system (GO:0032291)3.07709969
89central nervous system myelination (GO:0022010)3.07709969
90positive regulation of neurotransmitter secretion (GO:0001956)3.05827814
91synaptic transmission (GO:0007268)3.05081575
92positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.04961318
93regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.02706169
94cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.01104664
95learning (GO:0007612)3.01084680
96mating behavior (GO:0007617)3.00512159
97establishment of mitochondrion localization (GO:0051654)3.00330636
98regulation of ARF protein signal transduction (GO:0032012)3.00035607
99membrane depolarization during action potential (GO:0086010)2.99931790
100synapse assembly (GO:0007416)2.98819959
101positive regulation of neurotransmitter transport (GO:0051590)2.97936969
102negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.97598544
103mechanosensory behavior (GO:0007638)2.96252039
104neuromuscular process (GO:0050905)2.95754486
105regulation of voltage-gated calcium channel activity (GO:1901385)2.93466697
106regulation of synaptic transmission (GO:0050804)2.92416215
107* regulation of dendritic spine development (GO:0060998)2.90630107
108potassium ion import (GO:0010107)2.90104793
109cell migration in hindbrain (GO:0021535)2.89962890
110neurotransmitter uptake (GO:0001504)2.89618273
111cell communication by electrical coupling (GO:0010644)2.89167609
112regulation of calcium ion-dependent exocytosis (GO:0017158)2.89165253
113vesicle transport along microtubule (GO:0047496)2.87705713

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.67640564
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07271575
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.06488991
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.02340536
5GBX2_23144817_ChIP-Seq_PC3_Human3.00477647
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.82487971
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.82487971
8DROSHA_22980978_ChIP-Seq_HELA_Human2.70313442
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.66964707
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.64849089
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61916769
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.56444782
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.54762492
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.51221123
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50626409
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46161586
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46019088
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.37254117
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.36304197
20* RNF2_27304074_Chip-Seq_ESCs_Mouse2.25569658
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.22962228
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.18396717
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.17361268
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.14167736
25* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.13418678
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90530994
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.87321452
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81162914
29AR_21572438_ChIP-Seq_LNCaP_Human1.75901942
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75137389
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.71097046
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.65619053
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46331691
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45889703
35RING1B_27294783_Chip-Seq_ESCs_Mouse1.41435931
36SMAD4_21799915_ChIP-Seq_A2780_Human1.38750057
37RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.37112049
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33919284
39DNAJC2_21179169_ChIP-ChIP_NT2_Human1.32649903
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30304910
41* KDM2B_26808549_Chip-Seq_K562_Human1.28070224
42TAF15_26573619_Chip-Seq_HEK293_Human1.26639572
43WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26339507
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24539773
45* RING1B_27294783_Chip-Seq_NPCs_Mouse1.24154095
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22621151
47* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21718765
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20647728
49SOX2_21211035_ChIP-Seq_LN229_Gbm1.20098097
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17798071
51AR_19668381_ChIP-Seq_PC3_Human1.17310822
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.16648582
53OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.15541967
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15424187
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.15267319
56STAT3_23295773_ChIP-Seq_U87_Human1.13461751
57P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12424036
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11960493
59ZNF274_21170338_ChIP-Seq_K562_Hela1.10880170
60EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10119092
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07437370
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07029136
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05983138
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04006498
65MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02157514
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02049907
67RNF2_27304074_Chip-Seq_NSC_Mouse1.01793729
68P300_19829295_ChIP-Seq_ESCs_Human1.01392987
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01160088
70AR_25329375_ChIP-Seq_VCAP_Human1.01134719
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.01022336
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99878497
73GATA1_26923725_Chip-Seq_HPCs_Mouse0.99481068
74BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98578861
75TP53_20018659_ChIP-ChIP_R1E_Mouse0.98076987
76AHR_22903824_ChIP-Seq_MCF-7_Human0.98000975
77CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97781750
78* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97775743
79TCF4_23295773_ChIP-Seq_U87_Human0.97594885
80YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96377257
81SMAD_19615063_ChIP-ChIP_OVARY_Human0.95949918
82ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95232858
83TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94997424
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94479586
85SMAD4_21741376_ChIP-Seq_HESCs_Human0.94124110
86TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93963679
87OCT4_19829295_ChIP-Seq_ESCs_Human0.93894591
88PIAS1_25552417_ChIP-Seq_VCAP_Human0.93805450
89TET1_21490601_ChIP-Seq_MESCs_Mouse0.93407456
90SMAD3_21741376_ChIP-Seq_HESCs_Human0.93012972
91SMAD3_21741376_ChIP-Seq_ESCs_Human0.93004256
92CTCF_27219007_Chip-Seq_Bcells_Human0.91289295
93PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90591726
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89290780
95SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88976725
96ESR2_21235772_ChIP-Seq_MCF-7_Human0.88206015
97NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86645202
98GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86171253
99TP53_16413492_ChIP-PET_HCT116_Human0.85967575
100RUNX2_22187159_ChIP-Seq_PCA_Human0.85903072
101TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85748399
102RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84007072
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83534512
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.82973862
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82973862
106CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81276853
107SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80713941
108RXR_22108803_ChIP-Seq_LS180_Human0.79853985
109TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79802572
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.79743494
111* PRDM14_20953172_ChIP-Seq_ESCs_Human0.78856193
112KLF4_19829295_ChIP-Seq_ESCs_Human0.77853374
113EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.77572306
114CTNNB1_20460455_ChIP-Seq_HCT116_Human0.76541585
115* SMC4_20622854_ChIP-Seq_HELA_Human0.74391709
116DPY_21335234_ChIP-Seq_ESCs_Mouse0.73015155
117ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.71308866

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.72504463
2MP0003880_abnormal_central_pattern4.56229019
3MP0003635_abnormal_synaptic_transmissio4.18538585
4MP0004270_analgesia4.02344156
5MP0009745_abnormal_behavioral_response3.39955491
6MP0009046_muscle_twitch3.36051719
7MP0002063_abnormal_learning/memory/cond3.26959616
8MP0002064_seizures3.24319295
9MP0005423_abnormal_somatic_nervous3.19563724
10MP0001486_abnormal_startle_reflex2.82020299
11MP0002272_abnormal_nervous_system2.74789623
12MP0002572_abnormal_emotion/affect_behav2.74683326
13MP0002734_abnormal_mechanical_nocicepti2.72498924
14MP0002822_catalepsy2.64349688
15MP0001968_abnormal_touch/_nociception2.64226044
16MP0001501_abnormal_sleep_pattern2.18324107
17MP0008569_lethality_at_weaning2.18295887
18MP0001440_abnormal_grooming_behavior2.13555819
19MP0003329_amyloid_beta_deposits2.07946191
20MP0000778_abnormal_nervous_system2.00751805
21MP0002733_abnormal_thermal_nociception1.96627320
22MP0004885_abnormal_endolymph1.96389397
23MP0002067_abnormal_sensory_capabilities1.92092576
24MP0001970_abnormal_pain_threshold1.91500414
25MP0002735_abnormal_chemical_nociception1.88982780
26MP0002736_abnormal_nociception_after1.88465617
27MP0009780_abnormal_chondrocyte_physiolo1.85134984
28MP0004858_abnormal_nervous_system1.83271873
29MP0002184_abnormal_innervation1.83007749
30MP0004811_abnormal_neuron_physiology1.77096528
31MP0002557_abnormal_social/conspecific_i1.75696588
32MP0000955_abnormal_spinal_cord1.71995994
33MP0004924_abnormal_behavior1.71356481
34MP0005386_behavior/neurological_phenoty1.71356481
35MP0000920_abnormal_myelination1.62834755
36MP0002882_abnormal_neuron_morphology1.52580444
37MP0002909_abnormal_adrenal_gland1.51830321
38MP0003879_abnormal_hair_cell1.51051253
39MP0002066_abnormal_motor_capabilities/c1.50953960
40MP0004142_abnormal_muscle_tone1.44950510
41MP0003633_abnormal_nervous_system1.43597539
42MP0003123_paternal_imprinting1.42181217
43MP0001984_abnormal_olfaction1.38045249
44MP0005646_abnormal_pituitary_gland1.37912328
45MP0003690_abnormal_glial_cell1.35520437
46MP0003631_nervous_system_phenotype1.27401238
47MP0004742_abnormal_vestibular_system1.26982513
48MP0001905_abnormal_dopamine_level1.22808475
49MP0002638_abnormal_pupillary_reflex1.22140043
50MP0005645_abnormal_hypothalamus_physiol1.21421146
51MP0001529_abnormal_vocalization1.19709910
52MP0002152_abnormal_brain_morphology1.19461550
53MP0003787_abnormal_imprinting1.18205577
54MP0004145_abnormal_muscle_electrophysio1.14152705
55MP0001502_abnormal_circadian_rhythm1.13997861
56MP0002229_neurodegeneration1.13858412
57MP0003634_abnormal_glial_cell1.11688998
58MP0006276_abnormal_autonomic_nervous1.11638647
59MP0003632_abnormal_nervous_system1.11567075
60MP0000566_synostosis1.07832307
61MP0001177_atelectasis1.01450334
62MP0008872_abnormal_physiological_respon0.97691728
63MP0001485_abnormal_pinna_reflex0.93514887
64MP0002069_abnormal_eating/drinking_beha0.92293574
65MP0005551_abnormal_eye_electrophysiolog0.92089362
66MP0008874_decreased_physiological_sensi0.91574743
67MP0005499_abnormal_olfactory_system0.91086340
68MP0005394_taste/olfaction_phenotype0.91086340
69MP0003283_abnormal_digestive_organ0.90939321
70MP0008877_abnormal_DNA_methylation0.90578525
71MP0003121_genomic_imprinting0.90161288
72MP0001963_abnormal_hearing_physiology0.89658228
73MP0004133_heterotaxia0.89364394
74MP0000604_amyloidosis0.87910217
75MP0003075_altered_response_to0.87798152
76MP0005409_darkened_coat_color0.85624630
77MP0002752_abnormal_somatic_nervous0.85555952
78MP0003122_maternal_imprinting0.83490163
79MP0004085_abnormal_heartbeat0.80269529
80MP0004043_abnormal_pH_regulation0.78803313
81MP0001346_abnormal_lacrimal_gland0.78705547
82MP0000631_abnormal_neuroendocrine_gland0.77587719
83MP0008961_abnormal_basal_metabolism0.77529519
84MP0001986_abnormal_taste_sensitivity0.77407873
85MP0000751_myopathy0.77292215
86MP0004147_increased_porphyrin_level0.77225736
87MP0003137_abnormal_impulse_conducting0.75425270
88MP0001188_hyperpigmentation0.75424437
89MP0005623_abnormal_meninges_morphology0.74263642
90MP0000569_abnormal_digit_pigmentation0.73866536
91MP0010386_abnormal_urinary_bladder0.73610523
92MP0005167_abnormal_blood-brain_barrier0.72324459
93MP0002090_abnormal_vision0.68851823
94MP0005535_abnormal_body_temperature0.68046858
95MP0005410_abnormal_fertilization0.67979171
96MP0001299_abnormal_eye_distance/0.67802035
97MP0003861_abnormal_nervous_system0.66926767
98MP0002249_abnormal_larynx_morphology0.66882529
99MP0001348_abnormal_lacrimal_gland0.61982668
100MP0004130_abnormal_muscle_cell0.61183007
101MP0000013_abnormal_adipose_tissue0.60899282
102MP0000579_abnormal_nail_morphology0.59326659
103MP0010769_abnormal_survival0.58700091
104MP0001943_abnormal_respiration0.56896629
105MP0010768_mortality/aging0.55013891
106MP0002653_abnormal_ependyma_morphology0.54774299
107MP0002082_postnatal_lethality0.54722521
108MP0010770_preweaning_lethality0.54722521
109MP0001664_abnormal_digestion0.52983211
110MP0006292_abnormal_olfactory_placode0.52423530
111MP0003938_abnormal_ear_development0.52231334
112MP0003172_abnormal_lysosome_physiology0.51232567
113MP0000026_abnormal_inner_ear0.50215991
114MP0003956_abnormal_body_size0.50104821

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.09155986
2Focal motor seizures (HP:0011153)6.61043527
3Focal seizures (HP:0007359)5.40971431
4Visual hallucinations (HP:0002367)4.98881550
5Progressive cerebellar ataxia (HP:0002073)4.48319042
6Action tremor (HP:0002345)4.44553109
7Epileptic encephalopathy (HP:0200134)4.44035846
8Supranuclear gaze palsy (HP:0000605)4.08854302
9Atonic seizures (HP:0010819)4.06755680
10Ankle clonus (HP:0011448)4.02415251
11Febrile seizures (HP:0002373)3.76274841
12Broad-based gait (HP:0002136)3.58074596
13Dysmetria (HP:0001310)3.56047754
14Gaze-evoked nystagmus (HP:0000640)3.54082166
15Absence seizures (HP:0002121)3.50483452
16Neurofibrillary tangles (HP:0002185)3.49575899
17Generalized tonic-clonic seizures (HP:0002069)3.47701161
18Dysdiadochokinesis (HP:0002075)3.39304508
19Poor eye contact (HP:0000817)3.32692904
20Dialeptic seizures (HP:0011146)3.31374771
21Intention tremor (HP:0002080)3.29016905
22Abnormality of the corticospinal tract (HP:0002492)3.27104204
23Mutism (HP:0002300)3.24101824
24Spastic gait (HP:0002064)3.20660475
25Urinary bladder sphincter dysfunction (HP:0002839)3.18974462
26Impaired vibration sensation in the lower limbs (HP:0002166)3.16074560
27Depression (HP:0000716)3.10818465
28Postural instability (HP:0002172)3.08551382
29Cerebral inclusion bodies (HP:0100314)3.05745391
30Cerebral hypomyelination (HP:0006808)3.02777514
31Genetic anticipation (HP:0003743)3.02579681
32Abnormal social behavior (HP:0012433)3.01662004
33Impaired social interactions (HP:0000735)3.01662004
34Scanning speech (HP:0002168)2.99301980
35Hemiparesis (HP:0001269)2.94534630
36Abnormality of the lower motor neuron (HP:0002366)2.94330555
37Papilledema (HP:0001085)2.89920576
38Sleep apnea (HP:0010535)2.88738379
39Anxiety (HP:0000739)2.87489949
40Hyperventilation (HP:0002883)2.83966867
41Abnormal eating behavior (HP:0100738)2.78604972
42Urinary urgency (HP:0000012)2.78431050
43Truncal ataxia (HP:0002078)2.77355106
44Abnormality of binocular vision (HP:0011514)2.72192840
45Diplopia (HP:0000651)2.72192840
46Hemiplegia (HP:0002301)2.69241197
47Torticollis (HP:0000473)2.64302651
48Amblyopia (HP:0000646)2.63411064
49Impaired smooth pursuit (HP:0007772)2.62570163
50Megalencephaly (HP:0001355)2.58079094
51Drooling (HP:0002307)2.54298660
52Excessive salivation (HP:0003781)2.54298660
53Lower limb muscle weakness (HP:0007340)2.45859905
54Focal dystonia (HP:0004373)2.41025221
55Termporal pattern (HP:0011008)2.39999761
56Insidious onset (HP:0003587)2.39999761
57Stereotypic behavior (HP:0000733)2.38669057
58Abnormality of ocular smooth pursuit (HP:0000617)2.37188974
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.36904520
60Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.36904520
61Progressive inability to walk (HP:0002505)2.36124178
62Amyotrophic lateral sclerosis (HP:0007354)2.34759486
63Bradykinesia (HP:0002067)2.31161833
64Clonus (HP:0002169)2.29933130
65Limb dystonia (HP:0002451)2.26229868
66Absent speech (HP:0001344)2.26213343
67Annular pancreas (HP:0001734)2.23180282
68Ventricular fibrillation (HP:0001663)2.22306391
69Insomnia (HP:0100785)2.20814496
70Impaired vibratory sensation (HP:0002495)2.20720970
71Generalized myoclonic seizures (HP:0002123)2.19899669
72Dysmetric saccades (HP:0000641)2.18249326
73Neuronal loss in central nervous system (HP:0002529)2.18043174
74Status epilepticus (HP:0002133)2.16771611
75Obstructive sleep apnea (HP:0002870)2.15783622
76Abnormality of saccadic eye movements (HP:0000570)2.12304233
77Craniofacial dystonia (HP:0012179)2.11199835
78Peripheral hypomyelination (HP:0007182)2.11110980
79Fetal akinesia sequence (HP:0001989)2.10188658
80Spastic tetraparesis (HP:0001285)2.06579972
81Delusions (HP:0000746)2.03556351
82Akinesia (HP:0002304)2.02968310
83Bronchomalacia (HP:0002780)2.02059786
84Epileptiform EEG discharges (HP:0011182)2.01843563
85EEG with generalized epileptiform discharges (HP:0011198)1.99375784
86Aplasia involving bones of the extremities (HP:0009825)1.98566974
87Aplasia involving bones of the upper limbs (HP:0009823)1.98566974
88Aplasia of the phalanges of the hand (HP:0009802)1.98566974
89Pheochromocytoma (HP:0002666)1.97212622
90Pointed chin (HP:0000307)1.95984967
91Hypsarrhythmia (HP:0002521)1.93758511
92Morphological abnormality of the pyramidal tract (HP:0002062)1.93438883
93Choreoathetosis (HP:0001266)1.93255327
94Gait ataxia (HP:0002066)1.93205385
95CNS hypomyelination (HP:0003429)1.92579539
96Onion bulb formation (HP:0003383)1.90746312
97Agitation (HP:0000713)1.89639826
98Tetraplegia (HP:0002445)1.86966813
99Apathy (HP:0000741)1.85424518
100Incomplete penetrance (HP:0003829)1.84421761
101Rigidity (HP:0002063)1.83501423
102Gait imbalance (HP:0002141)1.81883040
103Spastic tetraplegia (HP:0002510)1.80026359
104Inability to walk (HP:0002540)1.79914138
105Aqueductal stenosis (HP:0002410)1.79840508
106Increased circulating renin level (HP:0000848)1.79753670
107Bundle branch block (HP:0011710)1.78784881
108Lower limb amyotrophy (HP:0007210)1.78250845
109Polyphagia (HP:0002591)1.75666441
110Prolonged QT interval (HP:0001657)1.70939122
111Confusion (HP:0001289)1.67350712
112Hypoplasia of the corpus callosum (HP:0002079)1.65153541
113Specific learning disability (HP:0001328)1.62142783
114Morphological abnormality of the inner ear (HP:0011390)1.60709934

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.09239187
2NTRK33.81176825
3MAP3K93.80785534
4MARK13.48668773
5PAK62.55701271
6MAP3K42.55197908
7DAPK22.53948830
8MINK12.48865809
9PRKD32.23369735
10NTRK22.23121494
11NTRK12.14149013
12MAP2K71.96036808
13CAMKK11.90942508
14KSR21.85185473
15TNIK1.77396759
16TYRO31.72075095
17CDK191.66853714
18MAP2K41.62500259
19CDK51.62372810
20PRPF4B1.58915598
21GRK51.56534562
22OXSR11.54121936
23PNCK1.50945385
24UHMK11.40950829
25STK381.37601872
26SIK21.36700759
27RIPK41.35907659
28STK391.27861963
29MAPK131.27221390
30KSR11.26006206
31CASK1.19052879
32PHKG21.18472468
33PHKG11.18472468
34PRKCG1.14084851
35WNK11.13267434
36DAPK11.11903531
37MARK21.11291716
38FES1.10274747
39TAOK11.07679225
40STK111.07532301
41PLK21.06527240
42CAMKK21.05978426
43CDK151.03028205
44CDK181.00812184
45CAMK11.00805188
46MAP3K20.99556194
47SGK2230.98680964
48SGK4940.98680964
49CDK140.96961382
50MAP3K120.95552185
51ARAF0.94781397
52PRKCH0.93681499
53CAMK2A0.91019599
54CDK11A0.90607714
55MAP3K130.90595998
56LATS20.88428026
57PAK30.88067782
58CSNK1G20.86562907
59CAMK2B0.85564231
60NEK60.85159787
61PKN10.82882117
62PINK10.81384562
63DYRK20.81352465
64ICK0.77675661
65RIPK10.77099301
66ERBB20.75289493
67CAMK1G0.74520889
68DYRK1A0.74400981
69RET0.72683855
70PDK10.70501231
71PDPK10.69198346
72MAP3K110.65609426
73SGK10.64573351
74FGFR20.61243787
75MAPKAPK50.60562766
76MAPK150.59903918
77FYN0.59066557
78CAMK40.56121796
79PTK2B0.55770334
80TNK20.55389894
81INSRR0.54983354
82SGK30.53971234
83BRSK10.53843478
84RPS6KA30.52738359
85CAMK2G0.52470520
86RAF10.52312290
87CAMK2D0.52280233
88CDC42BPA0.51575270
89ROCK20.50914938
90PRKCZ0.50800674
91SGK20.48960176
92MAPK100.48904399
93MAP3K70.48473877
94FGR0.47832669
95LMTK20.47756970
96FRK0.46264386
97LIMK10.46153419
98WNK40.45807896
99BMPR20.44747312
100MAP2K60.44664123
101BCR0.43352210
102CSNK1G30.41720108
103MAP3K10.41445974
104CSNK1A1L0.40801103
105PRKCE0.40550933
106MAPK80.38034477
107PRKACA0.37967282
108DAPK30.37426618
109DMPK0.36526923
110PRKCA0.36218632
111WNK30.36105696
112CSNK1D0.34762366
113DDR20.34607647
114PRKG10.33725838
115ADRBK20.33618789
116MAPK120.33538028
117CSNK1E0.32836839
118CSNK1A10.31814952
119GSK3B0.31231818
120GRK10.30808320

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.47417815
2Synaptic vesicle cycle_Homo sapiens_hsa047213.09675909
3Glutamatergic synapse_Homo sapiens_hsa047242.74359976
4GABAergic synapse_Homo sapiens_hsa047272.73274583
5Olfactory transduction_Homo sapiens_hsa047402.70992580
6Circadian entrainment_Homo sapiens_hsa047132.65982995
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.55757814
8Long-term potentiation_Homo sapiens_hsa047202.53869641
9Morphine addiction_Homo sapiens_hsa050322.46901566
10Amphetamine addiction_Homo sapiens_hsa050312.29516719
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.21805437
12Salivary secretion_Homo sapiens_hsa049702.21086585
13Dopaminergic synapse_Homo sapiens_hsa047282.07349476
14Gastric acid secretion_Homo sapiens_hsa049711.96818185
15Cholinergic synapse_Homo sapiens_hsa047251.88664870
16Insulin secretion_Homo sapiens_hsa049111.87854130
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.84484783
18Long-term depression_Homo sapiens_hsa047301.79433726
19Taste transduction_Homo sapiens_hsa047421.70269284
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69706356
21Cocaine addiction_Homo sapiens_hsa050301.63417790
22Oxytocin signaling pathway_Homo sapiens_hsa049211.62086451
23Serotonergic synapse_Homo sapiens_hsa047261.62029087
24Renin secretion_Homo sapiens_hsa049241.58236192
25Calcium signaling pathway_Homo sapiens_hsa040201.52467983
26Nitrogen metabolism_Homo sapiens_hsa009101.46571035
27GnRH signaling pathway_Homo sapiens_hsa049121.42153580
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40779016
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40282129
30Axon guidance_Homo sapiens_hsa043601.39636720
31Vitamin B6 metabolism_Homo sapiens_hsa007501.35654328
32Gap junction_Homo sapiens_hsa045401.33672374
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32914573
34cAMP signaling pathway_Homo sapiens_hsa040241.31560440
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21687151
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20210291
37Type II diabetes mellitus_Homo sapiens_hsa049301.18952409
38Estrogen signaling pathway_Homo sapiens_hsa049151.13432876
39ErbB signaling pathway_Homo sapiens_hsa040121.10624101
40Glioma_Homo sapiens_hsa052141.06127515
41Histidine metabolism_Homo sapiens_hsa003401.05928502
42Phospholipase D signaling pathway_Homo sapiens_hsa040721.04010294
43Collecting duct acid secretion_Homo sapiens_hsa049661.03775445
44Melanogenesis_Homo sapiens_hsa049161.01627584
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99957868
46Dorso-ventral axis formation_Homo sapiens_hsa043200.99749597
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98592781
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.96065037
49Pancreatic secretion_Homo sapiens_hsa049720.92223290
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92207282
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88109296
52Cardiac muscle contraction_Homo sapiens_hsa042600.86232334
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84753924
54Choline metabolism in cancer_Homo sapiens_hsa052310.81239765
55Thyroid hormone synthesis_Homo sapiens_hsa049180.80425184
56Oocyte meiosis_Homo sapiens_hsa041140.79931645
57MAPK signaling pathway_Homo sapiens_hsa040100.74114585
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73718105
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71721727
60Phototransduction_Homo sapiens_hsa047440.71080410
61Dilated cardiomyopathy_Homo sapiens_hsa054140.70071493
62beta-Alanine metabolism_Homo sapiens_hsa004100.68888717
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.67751137
64Ras signaling pathway_Homo sapiens_hsa040140.66758419
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66337529
66Endocytosis_Homo sapiens_hsa041440.65964913
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65755718
68Vibrio cholerae infection_Homo sapiens_hsa051100.64934683
69VEGF signaling pathway_Homo sapiens_hsa043700.62129737
70ABC transporters_Homo sapiens_hsa020100.61606148
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61315022
72Bile secretion_Homo sapiens_hsa049760.60673152
73Rap1 signaling pathway_Homo sapiens_hsa040150.60621811
74Renal cell carcinoma_Homo sapiens_hsa052110.60437167
75Arginine and proline metabolism_Homo sapiens_hsa003300.60115641
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.58593839
77Inositol phosphate metabolism_Homo sapiens_hsa005620.58227040
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55006564
79Ovarian steroidogenesis_Homo sapiens_hsa049130.54920069
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53955012
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53314764
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52112964
83Circadian rhythm_Homo sapiens_hsa047100.49207756
84Alcoholism_Homo sapiens_hsa050340.48948533
85Wnt signaling pathway_Homo sapiens_hsa043100.47915537
86Alzheimers disease_Homo sapiens_hsa050100.46717969
87mTOR signaling pathway_Homo sapiens_hsa041500.46573586
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43815959
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43195509
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41487689
91Prion diseases_Homo sapiens_hsa050200.41032115
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40514093
93Mineral absorption_Homo sapiens_hsa049780.40228304
94Endometrial cancer_Homo sapiens_hsa052130.40006561
95Non-small cell lung cancer_Homo sapiens_hsa052230.39646955
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39434327
97Tight junction_Homo sapiens_hsa045300.39012011
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38606982
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38496042
100Chemokine signaling pathway_Homo sapiens_hsa040620.37645259
101Hippo signaling pathway_Homo sapiens_hsa043900.37244403
102Glucagon signaling pathway_Homo sapiens_hsa049220.37136493
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.36995560
104Butanoate metabolism_Homo sapiens_hsa006500.36368923
105Ether lipid metabolism_Homo sapiens_hsa005650.35258158
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33934142
107Arginine biosynthesis_Homo sapiens_hsa002200.31291447
108Type I diabetes mellitus_Homo sapiens_hsa049400.31237748
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30894944
110Fatty acid biosynthesis_Homo sapiens_hsa000610.30614958
111Hedgehog signaling pathway_Homo sapiens_hsa043400.30362955
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29781956
113Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28704828
114Linoleic acid metabolism_Homo sapiens_hsa005910.26632234
115AMPK signaling pathway_Homo sapiens_hsa041520.23306228

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