SRD5A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to follicle-stimulating hormone stimulus (GO:0071372)9.99606127
2C21-steroid hormone metabolic process (GO:0008207)9.63445886
3cilium or flagellum-dependent cell motility (GO:0001539)9.50317582
4estrogen biosynthetic process (GO:0006703)9.37839591
5drug catabolic process (GO:0042737)9.07226635
6* androgen biosynthetic process (GO:0006702)9.03475006
7cellular response to cadmium ion (GO:0071276)8.62635688
8cilium movement (GO:0003341)8.33187252
9motile cilium assembly (GO:0044458)8.00143636
10ethanol oxidation (GO:0006069)7.71861091
11primary alcohol catabolic process (GO:0034310)7.58987575
12ethanol metabolic process (GO:0006067)7.55418241
13epithelial cilium movement (GO:0003351)7.27695501
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.23506824
15response to follicle-stimulating hormone (GO:0032354)7.22094069
16xenobiotic catabolic process (GO:0042178)7.20252910
17response to nitrosative stress (GO:0051409)7.13378154
18negative regulation of fibrinolysis (GO:0051918)7.01982370
19epoxygenase P450 pathway (GO:0019373)6.71124073
20regulation of fibrinolysis (GO:0051917)6.70132929
21cellular response to zinc ion (GO:0071294)6.56387973
22cellular response to growth hormone stimulus (GO:0071378)6.40614439
23fibrinolysis (GO:0042730)6.23618489
24omega-hydroxylase P450 pathway (GO:0097267)6.12626697
25cellular response to interferon-alpha (GO:0035457)6.09635842
26progesterone metabolic process (GO:0042448)6.03875413
27ketone biosynthetic process (GO:0042181)5.96130974
28benzene-containing compound metabolic process (GO:0042537)5.89774960
29glyoxylate metabolic process (GO:0046487)5.88537092
30* hormone biosynthetic process (GO:0042446)5.84430849
31response to leptin (GO:0044321)5.70336405
32estrogen metabolic process (GO:0008210)5.52879495
33renal system process involved in regulation of blood volume (GO:0001977)5.50621484
34toxin metabolic process (GO:0009404)5.50467717
35drug metabolic process (GO:0017144)5.49849092
36erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.49095182
37L-phenylalanine catabolic process (GO:0006559)5.49095182
38adhesion of symbiont to host (GO:0044406)5.39413995
39cellular response to antibiotic (GO:0071236)5.19862427
40erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.15860252
41L-phenylalanine metabolic process (GO:0006558)5.15860252
42regulation of protein activation cascade (GO:2000257)5.15069686
43amino-acid betaine metabolic process (GO:0006577)5.15044237
44urea metabolic process (GO:0019627)5.12487722
45daunorubicin metabolic process (GO:0044597)5.04585396
46polyketide metabolic process (GO:0030638)5.04585396
47doxorubicin metabolic process (GO:0044598)5.04585396
48* androgen metabolic process (GO:0008209)4.99516956
49axoneme assembly (GO:0035082)4.97826796
50oxidative demethylation (GO:0070989)4.93535643
51phenylpropanoid metabolic process (GO:0009698)4.90092546
52bile acid metabolic process (GO:0008206)4.85870002
53peptidyl-glutamic acid carboxylation (GO:0017187)4.85202109
54protein carboxylation (GO:0018214)4.85202109
55regulation of complement activation (GO:0030449)4.84148805
56negative regulation of cholesterol transport (GO:0032375)4.70673442
57negative regulation of sterol transport (GO:0032372)4.70673442
58nitrogen cycle metabolic process (GO:0071941)4.69958424
59cellular response to gonadotropin stimulus (GO:0071371)4.61405493
60fat-soluble vitamin biosynthetic process (GO:0042362)4.60907561
61renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)4.56827377
62primary alcohol metabolic process (GO:0034308)4.48920733
63aminoglycoside antibiotic metabolic process (GO:0030647)4.48031854
64left/right pattern formation (GO:0060972)4.45785131
65diterpenoid biosynthetic process (GO:0016102)4.45073650
66bile acid and bile salt transport (GO:0015721)4.39148736
67cellular glucuronidation (GO:0052695)4.36861411
68low-density lipoprotein particle clearance (GO:0034383)4.33180988
69complement activation, alternative pathway (GO:0006957)4.29407734
70uronic acid metabolic process (GO:0006063)4.29081969
71glucuronate metabolic process (GO:0019585)4.29081969
72negative regulation of blood coagulation (GO:0030195)4.29003753
73negative regulation of hemostasis (GO:1900047)4.29003753
74blood coagulation, intrinsic pathway (GO:0007597)4.21573983
75aromatic amino acid family catabolic process (GO:0009074)4.17922116
76positive regulation of triglyceride biosynthetic process (GO:0010867)4.17269827
77regulation of skeletal muscle contraction (GO:0014819)4.11192220
78one-carbon compound transport (GO:0019755)4.10333337
79high-density lipoprotein particle remodeling (GO:0034375)4.08636724
80cholesterol catabolic process (GO:0006707)4.06199368
81sterol catabolic process (GO:0016127)4.06199368
82alpha-linolenic acid metabolic process (GO:0036109)4.01420617
83response to lead ion (GO:0010288)3.99301888
84carnitine metabolic process (GO:0009437)3.97274347
85urea cycle (GO:0000050)3.96834282
86cellular response to epinephrine stimulus (GO:0071872)3.96416924
87negative regulation of humoral immune response (GO:0002921)3.95708600
88regulation of cholesterol biosynthetic process (GO:0045540)3.94144749
89negative regulation of coagulation (GO:0050819)3.92301200
90serine family amino acid catabolic process (GO:0009071)3.92030350
91pyrimidine-containing compound transmembrane transport (GO:0072531)3.89989614
92regulation of plasminogen activation (GO:0010755)3.84097356
93retinoic acid metabolic process (GO:0042573)3.82780616
94negative regulation of wound healing (GO:0061045)3.77461302
95linoleic acid metabolic process (GO:0043651)3.76112467
96cellular response to toxic substance (GO:0097237)3.75958097
97regulation of male gonad development (GO:2000018)3.66891665
98S-adenosylmethionine metabolic process (GO:0046500)3.66428809
99regulation of cilium movement (GO:0003352)3.63870167
100intestinal cholesterol absorption (GO:0030299)3.63380447
101potassium ion homeostasis (GO:0055075)3.62562186
102glutathione derivative metabolic process (GO:1901685)3.59849450
103glutathione derivative biosynthetic process (GO:1901687)3.59849450
104* cellular hormone metabolic process (GO:0034754)3.58966198
105glycine metabolic process (GO:0006544)3.58630123
106heme transport (GO:0015886)3.58393305
107vitamin transmembrane transport (GO:0035461)3.58377458
108coenzyme catabolic process (GO:0009109)3.57643190
109regulation of cholesterol storage (GO:0010885)3.57397901
110reverse cholesterol transport (GO:0043691)3.56297426
111response to gonadotropin (GO:0034698)3.55465088
112positive regulation of systemic arterial blood pressure (GO:0003084)3.52967903
113positive regulation of blood coagulation (GO:0030194)3.52278277
114positive regulation of hemostasis (GO:1900048)3.52278277
115ventricular system development (GO:0021591)3.51520617
116bile acid biosynthetic process (GO:0006699)3.50810457
117negative regulation of cytosolic calcium ion concentration (GO:0051481)3.50653991
118negative regulation of lipase activity (GO:0060192)3.47905032
119alkaloid metabolic process (GO:0009820)3.47789713
120positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.45075638
121regulation of triglyceride catabolic process (GO:0010896)3.44616026
122flavonoid metabolic process (GO:0009812)3.41748074
123response to growth hormone (GO:0060416)3.40536400
124renal absorption (GO:0070293)3.38655793
125phagocytosis, recognition (GO:0006910)3.36951843
126response to mercury ion (GO:0046689)3.36484083
127regulation of humoral immune response (GO:0002920)3.36198944
128regulation of triglyceride biosynthetic process (GO:0010866)3.32704156
129left/right axis specification (GO:0070986)3.32300658
130phospholipid efflux (GO:0033700)3.30414882
131acylglycerol homeostasis (GO:0055090)3.29213221
132triglyceride homeostasis (GO:0070328)3.29213221
133aldehyde catabolic process (GO:0046185)3.27548958
134positive regulation of coagulation (GO:0050820)3.26975712
135fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.26932870
136negative regulation of fatty acid biosynthetic process (GO:0045717)3.25123587
137hormone catabolic process (GO:0042447)3.24146419
138intracellular lipid transport (GO:0032365)3.23972721
139terpenoid biosynthetic process (GO:0016114)3.22565972
140positive regulation of steroid biosynthetic process (GO:0010893)3.22043689
141retinal metabolic process (GO:0042574)3.20954506
142negative regulation of B cell mediated immunity (GO:0002713)3.19914882
143negative regulation of immunoglobulin mediated immune response (GO:0002890)3.19914882
144positive regulation of triglyceride metabolic process (GO:0090208)3.17658040
145negative regulation of protein activation cascade (GO:2000258)3.17053451
146L-ascorbic acid metabolic process (GO:0019852)3.16948873
147positive regulation of male gonad development (GO:2000020)3.16339999
148regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.15986870
149circadian sleep/wake cycle process (GO:0022410)3.15698524
150cellular aldehyde metabolic process (GO:0006081)3.13682895
151regulation of female gonad development (GO:2000194)3.11614375
152regulation of systemic arterial blood pressure by hormone (GO:0001990)3.09637855
153regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.09637855
154endocrine process (GO:0050886)3.09637855
155* steroid biosynthetic process (GO:0006694)3.08845992
156response to interferon-alpha (GO:0035455)3.06558808
157protein activation cascade (GO:0072376)3.06113209
158response to epinephrine (GO:0071871)3.04978696
159very-low-density lipoprotein particle assembly (GO:0034379)3.04272230
160response to corticosterone (GO:0051412)3.04083847
161indole-containing compound catabolic process (GO:0042436)3.01323835
162indolalkylamine catabolic process (GO:0046218)3.01323835
163tryptophan catabolic process (GO:0006569)3.01323835
164NADP metabolic process (GO:0006739)3.00666431
165sensory perception of smell (GO:0007608)2.98180210
166xenobiotic metabolic process (GO:0006805)2.97837191
167cellular ketone metabolic process (GO:0042180)2.96801613
168regulation of cardioblast proliferation (GO:0003264)2.96383072
169regulation of secondary heart field cardioblast proliferation (GO:0003266)2.96383072
170cytokine metabolic process (GO:0042107)2.96229653
171relaxation of cardiac muscle (GO:0055119)2.94413660
172negative regulation of fatty acid transport (GO:2000192)2.91931012
173cellular response to dexamethasone stimulus (GO:0071549)2.90921798
174regulation of bile acid biosynthetic process (GO:0070857)2.87586795
175response to dexamethasone (GO:0071548)2.80713823
176regulation of steroid biosynthetic process (GO:0050810)2.79448643
177secondary metabolic process (GO:0019748)2.76350765
178regulation of cholesterol homeostasis (GO:2000188)2.71739337
179detection of molecule of bacterial origin (GO:0032490)2.69578798
180regulation of cholesterol metabolic process (GO:0090181)2.69137972
181sterol metabolic process (GO:0016125)2.68624916
182negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.65099279
183sulfation (GO:0051923)2.62074677
184plasma lipoprotein particle remodeling (GO:0034369)2.61601774
185protein-lipid complex remodeling (GO:0034368)2.61601774
186macromolecular complex remodeling (GO:0034367)2.61601774
187cholesterol efflux (GO:0033344)2.60079845
188positive regulation of nitric-oxide synthase activity (GO:0051000)2.60049148
189C21-steroid hormone biosynthetic process (GO:0006700)15.3732805
190glucocorticoid biosynthetic process (GO:0006704)11.8657260
191axonemal dynein complex assembly (GO:0070286)11.5054782
192exogenous drug catabolic process (GO:0042738)10.5154727
193glucocorticoid metabolic process (GO:0008211)10.0616207

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.86857587
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.12542040
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.88943842
4CLOCK_20551151_ChIP-Seq_293T_Human3.72736017
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.58890386
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.44793947
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.23464602
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.87206135
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.84166615
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.65609593
11ESR1_15608294_ChIP-ChIP_MCF-7_Human2.56334447
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.55370449
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.55266433
14CDX2_20551321_ChIP-Seq_CACO-2_Human2.50761080
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.50412941
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.25430140
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.19135357
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.07521493
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.06130315
20ESR1_20079471_ChIP-ChIP_T-47D_Human1.96393435
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.91277892
22* FOXA2_19822575_ChIP-Seq_HepG2_Human1.84811149
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79446568
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79342795
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.77309166
26AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.69246191
27FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.66512973
28ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.61382370
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.60745530
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58761169
31HNF4A_19822575_ChIP-Seq_HepG2_Human1.54755304
32ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.53159321
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50750178
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.49924938
35KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.49803686
36KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.49803686
37KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.49803686
38HIF1A_21447827_ChIP-Seq_MCF-7_Human1.47960888
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.45101937
40FOXA1_25552417_ChIP-Seq_VCAP_Human1.41071142
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40336808
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.37217904
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34419600
44CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33462075
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32992280
46PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.31780001
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31057633
48TP63_23658742_ChIP-Seq_EP156T_Human1.30117963
49SOX2_27498859_Chip-Seq_STOMACH_Mouse1.29679395
50SMC4_20622854_ChIP-Seq_HELA_Human1.29560335
51HNFA_21074721_ChIP-Seq_CACO-2_Human1.29052329
52EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27732731
53* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.25757208
54* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.25757208
55ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23926272
56PHF8_20622853_ChIP-Seq_HELA_Human1.23363317
57GATA4_25053715_ChIP-Seq_YYC3_Human1.22624089
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20503684
59FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20414789
60CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.20223532
61SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19714862
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18558893
63ZNF263_19887448_ChIP-Seq_K562_Human1.15588313
64CBP_21632823_ChIP-Seq_H3396_Human1.14468980
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.14192067
66CEBPB_22108803_ChIP-Seq_LS180_Human1.13046498
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11624120
68* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.11604209
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.09724364
70* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.07449963
71TP53_18474530_ChIP-ChIP_U2OS_Human1.07248010
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06884730
73RUNX1_27514584_Chip-Seq_MCF-7_Human1.06835914
74AHR_22903824_ChIP-Seq_MCF-7_Human1.06741340
75RXR_22108803_ChIP-Seq_LS180_Human1.06359281
76TP53_20018659_ChIP-ChIP_R1E_Mouse1.06122290
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.05744460
78TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.04487760
79TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04054678
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03405906
81EGR1_19032775_ChIP-ChIP_M12_Human1.03352345
82FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03101357
83NFYA_21822215_ChIP-Seq_K562_Human1.02749403
84STAT1_20625510_ChIP-Seq_HELA_Human1.02382513
85* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01997830
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01594033
87* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.01556450
88NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01371284
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01371284
90RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00570387
91* ETV1_20927104_ChIP-Seq_GIST48_Human0.99980895
92SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99436301
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99436301
94BCAT_22108803_ChIP-Seq_LS180_Human0.98916231
95ELF1_20517297_ChIP-Seq_JURKAT_Human0.98148790
96CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97873012
97* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97857834
98RACK7_27058665_Chip-Seq_MCF-7_Human0.97496643
99SOX2_21211035_ChIP-Seq_LN229_Human0.96794044
100GATA3_24758297_ChIP-Seq_MCF-7_Human0.96778448
101* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96125701
102GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.95945076
103BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95767388
104SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95600307
105KDM2B_26808549_Chip-Seq_K562_Human0.95596556
106CTCF_27219007_Chip-Seq_Bcells_Human0.94856709
107FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94462809
108P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93789868
109TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93519572
110TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92843195
111ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92546978
112MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92307973
113PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92300813
114KLF5_25053715_ChIP-Seq_YYC3_Human0.92215925
115DROSHA_22980978_ChIP-Seq_HELA_Human0.91913769
116SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.91635620
117GATA6_21074721_ChIP-Seq_CACO-2_Human0.91210181
118ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90199794
119* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.89753698
120CTCF_20526341_ChIP-Seq_ESCs_Human0.89494083
121EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.88715650
122RING1B_27294783_Chip-Seq_ESCs_Mouse0.88629954
123RING1B_27294783_Chip-Seq_NPCs_Mouse0.88579020
124LXR_22292898_ChIP-Seq_THP-1_Human0.88293159
125NFYB_21822215_ChIP-Seq_K562_Human0.88222730
126KAP1_22055183_ChIP-Seq_ESCs_Mouse0.88094376
127BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.87943653
128TP63_22573176_ChIP-Seq_HFKS_Human0.87165954
129EP300_21415370_ChIP-Seq_HL-1_Mouse0.87004838
130RBPJ_21746931_ChIP-Seq_IB4_Human0.86786988
131* CBX2_22325352_ChIP-Seq_293T-Rex_Human0.86492552
132AR_20517297_ChIP-Seq_VCAP_Human0.86419731
133RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.86362414
134* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.86087222
135ZFP281_18757296_ChIP-ChIP_E14_Mouse0.85795114
136SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.85053962
137CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84384356
138* EED_16625203_ChIP-ChIP_MESCs_Mouse0.84202468
139AR_21572438_ChIP-Seq_LNCaP_Human0.83302566
140TBL1_22424771_ChIP-Seq_293T_Human0.82823577
141KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82354007
142FOXO3_23340844_ChIP-Seq_DLD1_Human0.82261017
143ERG_20517297_ChIP-Seq_VCAP_Human0.81814257
144RNF2_27304074_Chip-Seq_ESCs_Mouse0.81790415
145CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.81386868
146SOX2_20726797_ChIP-Seq_SW620_Human0.81059221
147GATA2_21666600_ChIP-Seq_HMVEC_Human0.80932389
148WT1_25993318_ChIP-Seq_PODOCYTE_Human0.80724281
149* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80720495
150DNAJC2_21179169_ChIP-ChIP_NT2_Human0.80687644
151IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.80536553
152CDX2_22108803_ChIP-Seq_LS180_Human0.80440867
153EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.80422459
154* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.80236773
155PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.80112859
156NR3C1_21868756_ChIP-Seq_MCF10A_Human0.78810423
157ER_23166858_ChIP-Seq_MCF-7_Human0.78627715
158* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.77930907
159KDM2B_26808549_Chip-Seq_SUP-B15_Human0.77642344
160GATA6_25053715_ChIP-Seq_YYC3_Human0.76845613
161TBX20_22328084_ChIP-Seq_HEART_Mouse0.76579594

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok5.40717806
2MP0008789_abnormal_olfactory_epithelium4.93603630
3MP0005499_abnormal_olfactory_system4.27767594
4MP0005394_taste/olfaction_phenotype4.27767594
5MP0002909_abnormal_adrenal_gland4.15104467
6MP0000639_abnormal_adrenal_gland4.07875779
7MP0000566_synostosis3.99870186
8MP0002254_reproductive_system_inflammat3.83879438
9MP0003195_calcinosis3.66563896
10MP0010030_abnormal_orbit_morphology3.56867354
11MP0003252_abnormal_bile_duct3.49768115
12MP0001666_abnormal_nutrient_absorption3.17203074
13MP0001346_abnormal_lacrimal_gland2.96241314
14MP0003868_abnormal_feces_composition2.81457644
15MP0001984_abnormal_olfaction2.80751939
16MP0002877_abnormal_melanocyte_morpholog2.75393673
17MP0002138_abnormal_hepatobiliary_system2.59973503
18MP0003186_abnormal_redox_activity2.53817907
19MP0000678_abnormal_parathyroid_gland2.48114501
20MP0005365_abnormal_bile_salt2.31143666
21MP0002876_abnormal_thyroid_physiology2.19701715
22MP0002653_abnormal_ependyma_morphology2.17375340
23MP0010329_abnormal_lipoprotein_level2.10617037
24MP0001765_abnormal_ion_homeostasis1.99908957
25MP0010368_abnormal_lymphatic_system1.99264956
26MP0009053_abnormal_anal_canal1.97212220
27MP0009697_abnormal_copulation1.96996212
28MP0004883_abnormal_blood_vessel1.96486567
29MP0009840_abnormal_foam_cell1.90707462
30MP0000762_abnormal_tongue_morphology1.81297360
31MP0002233_abnormal_nose_morphology1.78665835
32MP0003300_gastrointestinal_ulcer1.77820709
33MP0000537_abnormal_urethra_morphology1.73684387
34MP0008872_abnormal_physiological_respon1.73611819
35MP0002822_catalepsy1.70940492
36MP0003656_abnormal_erythrocyte_physiolo1.68119029
37MP0005319_abnormal_enzyme/_coenzyme1.62749328
38MP0003191_abnormal_cellular_cholesterol1.61241449
39MP0009780_abnormal_chondrocyte_physiolo1.58271191
40MP0001756_abnormal_urination1.49615011
41MP0009379_abnormal_foot_pigmentation1.47338171
42MP0001501_abnormal_sleep_pattern1.44435949
43MP0005408_hypopigmentation1.41579871
44MP0005636_abnormal_mineral_homeostasis1.38100738
45MP0000631_abnormal_neuroendocrine_gland1.36264768
46MP0005085_abnormal_gallbladder_physiolo1.33746574
47MP0002168_other_aberrant_phenotype1.31701756
48MP0002282_abnormal_trachea_morphology1.29789649
49MP0004043_abnormal_pH_regulation1.28888688
50MP0002249_abnormal_larynx_morphology1.28584819
51MP0000230_abnormal_systemic_arterial1.27584985
52MP0002139_abnormal_hepatobiliary_system1.26900358
53MP0003690_abnormal_glial_cell1.25771967
54MP0000049_abnormal_middle_ear1.25524007
55MP0004133_heterotaxia1.25040031
56MP0005623_abnormal_meninges_morphology1.24381445
57MP0002090_abnormal_vision1.23566891
58MP0002098_abnormal_vibrissa_morphology1.22785812
59MP0005164_abnormal_response_to1.22500534
60MP0003638_abnormal_response/metabolism_1.19382604
61MP0002277_abnormal_respiratory_mucosa1.17083593
62MP0003941_abnormal_skin_development1.15832409
63MP0002295_abnormal_pulmonary_circulatio1.14742005
64MP0009250_abnormal_appendicular_skeleto1.14420601
65MP0003806_abnormal_nucleotide_metabolis1.14233959
66MP0001764_abnormal_homeostasis1.12928959
67MP0005395_other_phenotype1.09927573
68MP0000613_abnormal_salivary_gland1.02862918
69MP0000538_abnormal_urinary_bladder1.00615185
70MP0005584_abnormal_enzyme/coenzyme_acti1.00078500
71MP0009643_abnormal_urine_homeostasis0.99748047
72MP0003942_abnormal_urinary_system0.99265527
73MP0000534_abnormal_ureter_morphology0.98320639
74MP0005647_abnormal_sex_gland0.97898403
75MP0010630_abnormal_cardiac_muscle0.96320737
76MP0009278_abnormal_bone_marrow0.96286303
77MP0005083_abnormal_biliary_tract0.94678911
78MP0005377_hearing/vestibular/ear_phenot0.93787840
79MP0003878_abnormal_ear_physiology0.93787840
80MP0005646_abnormal_pituitary_gland0.93243488
81MP0002118_abnormal_lipid_homeostasis0.92637958
82MP0004019_abnormal_vitamin_homeostasis0.91130432
83MP0004085_abnormal_heartbeat0.90615648
84MP0000467_abnormal_esophagus_morphology0.90370853
85MP0004264_abnormal_extraembryonic_tissu0.89943678
86MP0001905_abnormal_dopamine_level0.83684267
87MP0009763_increased_sensitivity_to0.83369790
88MP0001177_atelectasis0.83309156
89MP0006292_abnormal_olfactory_placode0.82885427
90MP0003953_abnormal_hormone_level0.81473987
91MP0005376_homeostasis/metabolism_phenot0.81332890
92MP0002160_abnormal_reproductive_system0.78773301
93MP0002132_abnormal_respiratory_system0.78586080
94MP0005023_abnormal_wound_healing0.78357275
95MP0003937_abnormal_limbs/digits/tail_de0.77845620
96MP0003938_abnormal_ear_development0.77648314
97MP0001661_extended_life_span0.77518037
98MP0006036_abnormal_mitochondrial_physio0.71420471
99MP0000647_abnormal_sebaceous_gland0.71266477
100MP0005360_urolithiasis0.70960858
101MP0003828_pulmonary_edema0.70615060
102MP0009642_abnormal_blood_homeostasis0.70373151
103MP0004084_abnormal_cardiac_muscle0.69236370
104MP0005187_abnormal_penis_morphology0.68345719
105MP0003385_abnormal_body_wall0.68117287
106MP0003566_abnormal_cell_adhesion0.67605514
107MP0003115_abnormal_respiratory_system0.67581101
108MP0005248_abnormal_Harderian_gland0.67535770
109MP0003879_abnormal_hair_cell0.65392387
110MP0002060_abnormal_skin_morphology0.65295350
111MP0005332_abnormal_amino_acid0.64689622
112MP0004233_abnormal_muscle_weight0.63965447
113MP0003755_abnormal_palate_morphology0.63489492
114MP0001270_distended_abdomen0.63231983
115MP0000598_abnormal_liver_morphology0.62072756
116MP0005389_reproductive_system_phenotype0.60882245
117MP0008469_abnormal_protein_level0.60213428
118MP0003075_altered_response_to0.59063125
119MP0001879_abnormal_lymphatic_vessel0.58793541
120MP0001915_intracranial_hemorrhage0.57861930
121MP0001502_abnormal_circadian_rhythm0.56439850
122MP0002136_abnormal_kidney_physiology0.55502277
123MP0000609_abnormal_liver_physiology0.55353326
124MP0005388_respiratory_system_phenotype0.54925340
125MP0002133_abnormal_respiratory_system0.54925340
126MP0004947_skin_inflammation0.54517441
127MP0008995_early_reproductive_senescence0.53035335
128MP0000681_abnormal_thyroid_gland0.52854602
129MP0005595_abnormal_vascular_smooth0.52673759
130MP0008004_abnormal_stomach_pH0.52160285
131MP0006138_congestive_heart_failure0.50881878
132MP0004782_abnormal_surfactant_physiolog0.50359338
133MP0002751_abnormal_autonomic_nervous0.48441538
134MP0005220_abnormal_exocrine_pancreas0.47803737
135MP0010234_abnormal_vibrissa_follicle0.46260763
136MP0010155_abnormal_intestine_physiology0.45792508
137MP0003718_maternal_effect0.45656575
138MP0009765_abnormal_xenobiotic_induced0.45502231
139MP0005464_abnormal_platelet_physiology0.44216539
140MP0005451_abnormal_body_composition0.43345273
141MP0000249_abnormal_blood_vessel0.42725218
142MP0002078_abnormal_glucose_homeostasis0.39729322
143MP0003011_delayed_dark_adaptation0.39114778
144MP0005166_decreased_susceptibility_to0.38647534
145MP0002971_abnormal_brown_adipose0.38611010
146MP0005165_increased_susceptibility_to0.38309356
147MP0001929_abnormal_gametogenesis0.38229358
148MP0008873_increased_physiological_sensi0.38169925
149MP0003698_abnormal_male_reproductive0.36520483
150MP0000858_altered_metastatic_potential0.35419974
151MP0004272_abnormal_basement_membrane0.34355949
152MP0005266_abnormal_metabolism0.33944347
153MP0001849_ear_inflammation0.33550060
154MP0005409_darkened_coat_color0.33531819
155MP0009764_decreased_sensitivity_to0.33498619
156MP0010678_abnormal_skin_adnexa0.33247676

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.58863730
2Renal salt wasting (HP:0000127)9.58750228
3Abnormal respiratory motile cilium morphology (HP:0005938)9.55556209
4Abnormal respiratory epithelium morphology (HP:0012253)9.55556209
5Abnormal ciliary motility (HP:0012262)9.39022847
6Dynein arm defect of respiratory motile cilia (HP:0012255)9.25923507
7Absent/shortened dynein arms (HP:0200106)9.25923507
8Rhinitis (HP:0012384)8.78758847
9Increased circulating renin level (HP:0000848)7.71016622
10Decreased circulating renin level (HP:0003351)7.35807208
11Abnormality of renin-angiotensin system (HP:0000847)7.22405268
12Chronic bronchitis (HP:0004469)6.64224973
13Bronchiectasis (HP:0002110)6.21313635
14Hyperaldosteronism (HP:0000859)5.89447349
15Enlarged penis (HP:0000040)5.86086710
16Nasal polyposis (HP:0100582)5.76580937
17Orthostatic hypotension (HP:0001278)5.45833455
18Hypoplasia of the uterus (HP:0000013)5.37780438
19Deep venous thrombosis (HP:0002625)5.16073558
20Neonatal onset (HP:0003623)4.95599914
21Abnormality of the nasal mucosa (HP:0000433)4.80132004
22Hyperkalemia (HP:0002153)4.71778245
23Aplasia/hypoplasia of the uterus (HP:0008684)4.55614420
24Lip pit (HP:0100267)4.45505632
25Stomach cancer (HP:0012126)4.43363624
26Prolonged partial thromboplastin time (HP:0003645)4.28894134
27Hypobetalipoproteinemia (HP:0003563)4.09508399
28Abnormality of aromatic amino acid family metabolism (HP:0004338)4.00851237
29Conjugated hyperbilirubinemia (HP:0002908)3.95788953
30Abnormal sex determination (HP:0012244)3.86808953
31Sex reversal (HP:0012245)3.86808953
32Infertility (HP:0000789)3.83943844
33Recurrent sinusitis (HP:0011108)3.69110566
34Bronchitis (HP:0012387)3.68602330
35Episodic fever (HP:0001954)3.60429554
36Chronic sinusitis (HP:0011109)3.45812221
37Recurrent otitis media (HP:0000403)3.42751330
38Accelerated skeletal maturation (HP:0005616)3.41714391
39Humeroradial synostosis (HP:0003041)3.39887320
40Synostosis involving the elbow (HP:0003938)3.39887320
41Abnormality of potassium homeostasis (HP:0011042)3.37808152
42Male infertility (HP:0003251)3.20785097
43* Bifid scrotum (HP:0000048)3.20519661
44Abnormality of complement system (HP:0005339)3.20425506
45Abnormal hemoglobin (HP:0011902)3.14792670
46Abnormal autonomic nervous system physiology (HP:0012332)3.14285462
47Intrahepatic cholestasis (HP:0001406)3.05435830
48Abnormality of the phalanges of the 2nd finger (HP:0009541)2.97649294
49Occipital encephalocele (HP:0002085)2.94481825
50Bronchomalacia (HP:0002780)2.93375939
51Clitoromegaly (HP:0000057)2.92749474
52Abnormality of the axillary hair (HP:0100134)2.88660968
53Abnormality of secondary sexual hair (HP:0009888)2.88660968
54Adrenal overactivity (HP:0002717)2.86608962
55Hyponatremia (HP:0002902)2.83860926
56Abnormality of sodium homeostasis (HP:0010931)2.79970231
57Rickets (HP:0002748)2.68300698
58Joint hemorrhage (HP:0005261)2.66869995
59Hyperlipoproteinemia (HP:0010980)2.66251093
60Azoospermia (HP:0000027)2.65845506
61Systemic lupus erythematosus (HP:0002725)2.65812338
62Fat malabsorption (HP:0002630)2.64495068
63Stenosis of the external auditory canal (HP:0000402)2.63626811
64Aplasia involving bones of the upper limbs (HP:0009823)2.56513290
65Aplasia of the phalanges of the hand (HP:0009802)2.56513290
66Aplasia involving bones of the extremities (HP:0009825)2.56513290
67Vascular calcification (HP:0004934)2.54141083
68Abnormality of the middle phalanges of the toes (HP:0010183)2.49345097
69Hyperactive renin-angiotensin system (HP:0000841)2.45637060
70Steatorrhea (HP:0002570)2.44982573
71True hermaphroditism (HP:0010459)2.41626630
72Chronic otitis media (HP:0000389)2.40973431
73Atelectasis (HP:0100750)2.39097211
74Pancreatic fibrosis (HP:0100732)2.38608582
75Atrioventricular block (HP:0001678)2.36653392
76Asymmetry of the thorax (HP:0001555)2.34845167
77Advanced eruption of teeth (HP:0006288)2.28843624
78Hypolipoproteinemia (HP:0010981)2.27279796
79Cardiovascular calcification (HP:0011915)2.25373773
80Down-sloping shoulders (HP:0200021)2.24051214
81Testicular neoplasm (HP:0010788)2.23482962
82Split foot (HP:0001839)2.23162692
83Turricephaly (HP:0000262)2.21547052
84Chronic hepatic failure (HP:0100626)2.20912893
85Glomerulonephritis (HP:0000099)2.19540167
86Hypotension (HP:0002615)2.18048845
87Short hallux (HP:0010109)2.15013750
88Hypokalemia (HP:0002900)2.13108502
89Cystic liver disease (HP:0006706)2.10981135
90Tubulointerstitial nephritis (HP:0001970)2.10947497
91Abnormality of the common coagulation pathway (HP:0010990)2.10945633
92Hyperglycinuria (HP:0003108)2.10192075
93Nasolacrimal duct obstruction (HP:0000579)2.10034616
94Mitral stenosis (HP:0001718)2.09984648
95Natal tooth (HP:0000695)2.08209204
96Prostate neoplasm (HP:0100787)2.03965221
97Primary adrenal insufficiency (HP:0008207)2.01955710
98Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.6782658
99Hypoplastic scapulae (HP:0000882)1.98841259
100Aplasia/Hypoplasia of the scapulae (HP:0006713)1.98841259
101Nephritis (HP:0000123)1.97227365
102Broad metatarsal (HP:0001783)1.97192652
103Recurrent gram-negative bacterial infections (HP:0005420)1.96839580
104Hypoplastic labia majora (HP:0000059)1.96390901
105Hemorrhage of the eye (HP:0011885)1.95953293
106Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.95680062
107Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.95256177
108Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.92737991
109Microglossia (HP:0000171)1.92049896
110Aplasia/Hypoplasia of the hallux (HP:0008362)1.90891523
111Bowed forearm bones (HP:0003956)1.90856694
112Bowing of the arm (HP:0006488)1.90856694
113Abnormality of glutamine family amino acid metabolism (HP:0010902)1.89071251
114Neonatal hypoglycemia (HP:0001998)1.88439261
115Abnormality of the intrinsic pathway (HP:0010989)1.88069524
116Distal lower limb muscle weakness (HP:0009053)1.87976264
117Spinal cord lesions (HP:0100561)1.86734049
118Syringomyelia (HP:0003396)1.86734049
119Cupped ear (HP:0000378)1.86288437
120Abnormality of the 2nd finger (HP:0004100)1.85291630
121Osteomalacia (HP:0002749)1.84506268
122Spontaneous abortion (HP:0005268)1.84002521
123Urethral obstruction (HP:0000796)1.83711216
124Abnormality of midbrain morphology (HP:0002418)1.83068601
125Molar tooth sign on MRI (HP:0002419)1.83068601
126Pancreatic cysts (HP:0001737)1.82486348
127Abnormality of pyrimidine metabolism (HP:0004353)1.82280290
128Abnormality of monocarboxylic acid metabolism (HP:0010996)1.81209154
129Abnormality of vitamin metabolism (HP:0100508)1.80864090
130Xanthomatosis (HP:0000991)1.80531911
131Abnormal spermatogenesis (HP:0008669)1.79776281
132Multifactorial inheritance (HP:0001426)1.79408787
133Abnormal atrioventricular conduction (HP:0005150)1.79273203
134Nephronophthisis (HP:0000090)1.79246024
135Morphological abnormality of the middle ear (HP:0008609)1.77334859
136Abnormality of the lacrimal duct (HP:0011481)1.77129022
137Postaxial foot polydactyly (HP:0001830)1.76307485
138Gonadal dysgenesis (HP:0000133)1.75601873
139Epidermoid cyst (HP:0200040)1.75498676
140Femoral bowing (HP:0002980)1.75365237
141Right ventricular cardiomyopathy (HP:0011663)1.75258341
142Alopecia of scalp (HP:0002293)1.73619002
143Abnormality of the renal collecting system (HP:0004742)1.71985548
144Abnormality of the labia majora (HP:0012881)1.70649973
145Absent hand (HP:0004050)1.69906168
146Cutaneous finger syndactyly (HP:0010554)1.69852771
147Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.69006599
148Abnormal biliary tract physiology (HP:0012439)1.66593652
149Bile duct proliferation (HP:0001408)1.66593652
150Tarsal synostosis (HP:0008368)1.66521872
151Purpura (HP:0000979)1.66406640
152Recurrent bronchitis (HP:0002837)1.65361764
153Congenital hepatic fibrosis (HP:0002612)1.64214454
154Fibular aplasia (HP:0002990)1.64185050
155Hyperammonemia (HP:0001987)1.63355049
156Abnormality of glycine metabolism (HP:0010895)1.62934420
157Abnormality of serine family amino acid metabolism (HP:0010894)1.62934420
158Hyperglycinemia (HP:0002154)1.59365216
159Renal tubular acidosis (HP:0001947)1.58463930
160Mesomelia (HP:0003027)1.57767227
161Bell-shaped thorax (HP:0001591)1.57551205
162Self-mutilation (HP:0000742)1.57278869
163Preauricular pit (HP:0004467)1.57221711
164Periauricular skin pits (HP:0100277)1.57221711
165Coronal craniosynostosis (HP:0004440)1.57148619
166Complement deficiency (HP:0004431)1.56095100
167Syncope (HP:0001279)1.55981373
1682-3 toe syndactyly (HP:0004691)1.55237900
169Hypercholesterolemia (HP:0003124)1.54884994
170Abnormality of proline metabolism (HP:0010907)1.54622485
171Hydroxyprolinuria (HP:0003080)1.54622485
172Generalized aminoaciduria (HP:0002909)1.48799537
173Reduced antithrombin III activity (HP:0001976)1.44686793
174Short nail (HP:0001799)1.42347116
175Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.37589111
176Aplasia/Hypoplasia of the tongue (HP:0010295)1.36895309
177Delayed CNS myelination (HP:0002188)1.34486006
178Abnormality of the renal medulla (HP:0100957)1.33567101
179Absent frontal sinuses (HP:0002688)1.33290714
180Anencephaly (HP:0002323)1.29908889
181Alkalosis (HP:0001948)1.27354925
182Flat acetabular roof (HP:0003180)1.27053339
183Decreased central vision (HP:0007663)1.26211028
184Nephropathy (HP:0000112)1.23304699
185* Male pseudohermaphroditism (HP:0000037)1.21398367
186Abnormality of nucleobase metabolism (HP:0010932)1.20889203
187Hyperphosphaturia (HP:0003109)1.20137338
188Metabolic acidosis (HP:0001942)1.19756448
189Furrowed tongue (HP:0000221)1.17850827

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT36.28913535
2ERN13.89657233
3MAP3K23.00875794
4EPHB22.81508755
5MAPK152.68345182
6SIK12.66179394
7MAP3K32.55089803
8TAOK32.53433761
9FGFR22.38452188
10RIPK12.37892721
11ZAK2.23931819
12FGFR42.13144446
13EEF2K1.97562138
14TRIB31.86003447
15BCKDK1.84901988
16LATS11.80263011
17HIPK21.66235181
18INSRR1.60788363
19SMG11.52219466
20STK381.50974031
21EPHB11.50372059
22MAP2K21.45835230
23PDK21.40261242
24BCR1.38585905
25PTK21.36386000
26STK241.29670731
27TRPM71.25643311
28TYK21.24007370
29TAOK21.22644708
30CDK71.22634463
31TBK11.21459088
32NEK91.19328144
33TIE11.18663561
34CDK81.18011239
35MST1R1.17931670
36MAP3K121.15917533
37TGFBR11.12295960
38MET1.10038331
39EPHA21.08984082
40MST41.05250568
41NEK61.01632633
42TESK10.99407869
43FGFR30.95662538
44TTK0.94854681
45DMPK0.94277672
46ICK0.93642526
47NME10.93540323
48CSK0.93222582
49PRKAA20.91075569
50TLK10.90436120
51PIK3CG0.90221386
52FER0.89682053
53STK390.88048498
54CSNK1A1L0.87309276
55BMPR20.86451592
56BMX0.84860195
57MAPK30.84670695
58MAP3K70.83531522
59PDPK10.82966559
60SIK30.81621936
61PTK60.81490634
62MAPK70.81400171
63ERBB20.81277891
64PNCK0.81253762
65GSK3A0.78677947
66MAPKAPK50.78589317
67STK100.78505420
68CAMK1D0.76947362
69PAK40.76119395
70MAP2K10.75505619
71PAK30.74934096
72PRKD10.73627414
73FRK0.72065646
74CAMK1G0.70984844
75TGFBR20.70790735
76ROCK20.69681021
77MYLK0.69423261
78ERBB40.68508502
79SIK20.67881282
80PINK10.67334643
81MARK20.66911144
82FGFR10.66278406
83RPS6KA20.65972854
84PTK2B0.62942910
85MAPKAPK30.62012500
86PIK3CA0.61260554
87NLK0.60722753
88IGF1R0.60081657
89BMPR1B0.58601081
90PRKCQ0.58531042
91PRKACG0.57295887
92STK38L0.56068363
93SGK30.55421656
94MKNK20.54980836
95RPS6KA40.54536466
96CSNK1A10.52561062
97RET0.52471707
98CAMKK10.52123370
99SGK4940.51823087
100SGK2230.51823087
101MAPK110.51001254
102WNK40.50990453
103LRRK20.50935398
104EPHA30.50731544
105ALK0.50701182
106CDK60.50489116
107STK160.50075690
108ROCK10.49248302
109MAPK10.48786148
110SGK10.46878822
111WNK10.46328174
112MAP3K140.46266920
113ERBB30.46252828
114BRSK20.46193461
115RPS6KB20.43919018
116ZAP700.43184339
117MUSK0.42843082
118OBSCN0.42584575
119CAMK2G0.42290617
120MARK30.41462187
121MAP2K70.40924602
122RPS6KL10.40773222
123RPS6KC10.40773222
124IKBKE0.40132024
125CAMK2D0.40014062
126MAP3K10.38825993
127MAP3K50.38194292
128PRKACA0.38143148
129PRKCH0.37574775
130PDK10.37303723
131LATS20.36726637
132PDGFRB0.36445818
133GRK60.35211184
134GRK10.34953052
135TAOK10.34390207
136PRKG10.34267994
137CAMK2B0.34191462
138PKN20.34112583
139MAPKAPK20.34100164
140CHUK0.34056595
141MAP2K40.33956255
142MAP3K130.33827554
143CDC42BPA0.33580996
144KSR20.33412776
145RPS6KA10.33335505
146PRKCZ0.33251162
147PRPF4B0.32665374
148PRKCD0.32143832
149SGK20.31399549
150PDGFRA0.31343490
151NTRK30.31187490
152PRKCA0.31138919
153RPS6KB10.30757033
154ABL20.30645897
155DYRK1B0.29963042
156PBK0.29384667
157PRKCI0.28801939
158EGFR0.28527553
159CAMKK20.28484493
160ARAF0.28208981
161AKT20.25684100

Predicted pathways (KEGG)

RankGene SetZ-score
1* Steroid hormone biosynthesis_Homo sapiens_hsa001405.56126761
2Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.88820645
3Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.80211925
4Aldosterone synthesis and secretion_Homo sapiens_hsa049253.75781617
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.65905538
6Pentose and glucuronate interconversions_Homo sapiens_hsa000403.53345947
7Chemical carcinogenesis_Homo sapiens_hsa052043.36810010
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.98446478
9Ovarian steroidogenesis_Homo sapiens_hsa049132.74184781
10Glutathione metabolism_Homo sapiens_hsa004802.41900047
11Tyrosine metabolism_Homo sapiens_hsa003502.15919292
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.98256360
13Caffeine metabolism_Homo sapiens_hsa002321.95844874
14Fatty acid metabolism_Homo sapiens_hsa012121.95012743
15Sulfur metabolism_Homo sapiens_hsa009201.71549347
16beta-Alanine metabolism_Homo sapiens_hsa004101.65912958
17Fatty acid degradation_Homo sapiens_hsa000711.61831249
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.59512347
19Starch and sucrose metabolism_Homo sapiens_hsa005001.55758836
20Bile secretion_Homo sapiens_hsa049761.53109915
21PPAR signaling pathway_Homo sapiens_hsa033201.44427239
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43170177
23Phenylalanine metabolism_Homo sapiens_hsa003601.38592710
24Butanoate metabolism_Homo sapiens_hsa006501.38194116
25Retinol metabolism_Homo sapiens_hsa008301.35116176
26Steroid biosynthesis_Homo sapiens_hsa001001.33436341
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.26961346
28Propanoate metabolism_Homo sapiens_hsa006401.20959224
29Nitrogen metabolism_Homo sapiens_hsa009101.19732959
30Histidine metabolism_Homo sapiens_hsa003401.15340021
31Vitamin digestion and absorption_Homo sapiens_hsa049771.14510916
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.09619209
33Fatty acid biosynthesis_Homo sapiens_hsa000611.07371139
34Fat digestion and absorption_Homo sapiens_hsa049751.06937251
35Circadian rhythm_Homo sapiens_hsa047101.02208806
36Tryptophan metabolism_Homo sapiens_hsa003800.99473614
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89597184
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89585249
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86884733
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86850815
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85071106
42Vitamin B6 metabolism_Homo sapiens_hsa007500.79325556
43Peroxisome_Homo sapiens_hsa041460.77723082
44Galactose metabolism_Homo sapiens_hsa000520.76836977
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72656855
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72067680
47Complement and coagulation cascades_Homo sapiens_hsa046100.69643341
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64986383
49Fatty acid elongation_Homo sapiens_hsa000620.64720969
50Prion diseases_Homo sapiens_hsa050200.63605464
51ABC transporters_Homo sapiens_hsa020100.58383836
52Pyruvate metabolism_Homo sapiens_hsa006200.55268699
53Olfactory transduction_Homo sapiens_hsa047400.53854296
54Renin secretion_Homo sapiens_hsa049240.50312501
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50133543
56Lysine degradation_Homo sapiens_hsa003100.49014694
57Sulfur relay system_Homo sapiens_hsa041220.46138755
58Insulin resistance_Homo sapiens_hsa049310.45173765
59Glycerolipid metabolism_Homo sapiens_hsa005610.43218579
60Biosynthesis of amino acids_Homo sapiens_hsa012300.41738091
61cAMP signaling pathway_Homo sapiens_hsa040240.41358489
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40845207
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40664799
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36149736
65Thyroid hormone synthesis_Homo sapiens_hsa049180.34674130
66Arginine biosynthesis_Homo sapiens_hsa002200.34185502
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30734767
68Gastric acid secretion_Homo sapiens_hsa049710.29426755
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.29328941
70African trypanosomiasis_Homo sapiens_hsa051430.29033378
71Arachidonic acid metabolism_Homo sapiens_hsa005900.28139521
72Carbon metabolism_Homo sapiens_hsa012000.28115665
73Sphingolipid metabolism_Homo sapiens_hsa006000.24798741
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24654430
75Staphylococcus aureus infection_Homo sapiens_hsa051500.24153592
76Axon guidance_Homo sapiens_hsa043600.23898694
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.22136527
78TNF signaling pathway_Homo sapiens_hsa046680.22115138
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.21397933
80Thyroid cancer_Homo sapiens_hsa052160.21144404
81Circadian entrainment_Homo sapiens_hsa047130.20899189
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.20405317
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20198688
84Estrogen signaling pathway_Homo sapiens_hsa049150.19907658
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.17418611
86Rheumatoid arthritis_Homo sapiens_hsa053230.16559859
87Dilated cardiomyopathy_Homo sapiens_hsa054140.16467094
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.16040838
89Arginine and proline metabolism_Homo sapiens_hsa003300.15015180
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.14268196
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.13886394
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.13643005
93Phagosome_Homo sapiens_hsa041450.13506508
94ECM-receptor interaction_Homo sapiens_hsa045120.12287248
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.11419090
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.11222795
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.11155287
98Cocaine addiction_Homo sapiens_hsa050300.10777919
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.09937137
100Adherens junction_Homo sapiens_hsa045200.09830269
101Huntingtons disease_Homo sapiens_hsa050160.09394212
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.08931303
103Linoleic acid metabolism_Homo sapiens_hsa005910.08009474
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.07811154
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.07123771
106Fructose and mannose metabolism_Homo sapiens_hsa000510.06742559
107Type II diabetes mellitus_Homo sapiens_hsa049300.06552755
108Amoebiasis_Homo sapiens_hsa051460.06189253
109Pertussis_Homo sapiens_hsa051330.04959339
110Pentose phosphate pathway_Homo sapiens_hsa000300.04720225
111One carbon pool by folate_Homo sapiens_hsa006700.03892020
112Tight junction_Homo sapiens_hsa045300.03614478
113Salivary secretion_Homo sapiens_hsa049700.02788156
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.02483603
115Metabolic pathways_Homo sapiens_hsa011000.02252136
116Toxoplasmosis_Homo sapiens_hsa051450.02136737
117Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.01637978
118Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.1490620
119Other glycan degradation_Homo sapiens_hsa00511-0.1446630
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1390234
121Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1351708
122Pathogenic Escherichia coli infection_Homo sapiens_hsa05130-0.1321339
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1250891
124Selenocompound metabolism_Homo sapiens_hsa00450-0.1085707
125Glucagon signaling pathway_Homo sapiens_hsa04922-0.1062573
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0939945
127Choline metabolism in cancer_Homo sapiens_hsa05231-0.0921629
128Hepatitis C_Homo sapiens_hsa05160-0.0642676
129Mineral absorption_Homo sapiens_hsa04978-0.0620393
130Serotonergic synapse_Homo sapiens_hsa04726-0.0110880

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