SREBF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)4.19693847
2cytoskeletal anchoring at plasma membrane (GO:0007016)4.11552331
3synaptic vesicle docking involved in exocytosis (GO:0016081)4.11281291
4positive regulation of histone deacetylation (GO:0031065)3.95478968
5regulation of translational fidelity (GO:0006450)3.75280701
6layer formation in cerebral cortex (GO:0021819)3.68297095
7regulation of NFAT protein import into nucleus (GO:0051532)3.48491390
8regulation of short-term neuronal synaptic plasticity (GO:0048172)3.45355785
9cellular potassium ion homeostasis (GO:0030007)3.42080323
10Golgi transport vesicle coating (GO:0048200)3.40625440
11COPI coating of Golgi vesicle (GO:0048205)3.40625440
12peptidyl-lysine dimethylation (GO:0018027)3.38811483
13regulation of synaptic vesicle exocytosis (GO:2000300)3.37097421
14heterochromatin organization (GO:0070828)3.34428297
15positive regulation of synapse maturation (GO:0090129)3.32515393
16protein retention in ER lumen (GO:0006621)3.30350919
17retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.28367215
18glutamate secretion (GO:0014047)3.27439563
19cell communication by electrical coupling (GO:0010644)3.24952012
20cerebellar granule cell differentiation (GO:0021707)3.24360632
21maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.23612816
22cell-cell junction maintenance (GO:0045217)3.21531397
23polarized epithelial cell differentiation (GO:0030859)3.18556053
24sodium ion export (GO:0071436)3.17334902
25glucocorticoid receptor signaling pathway (GO:0042921)3.14465273
26regulation of translational termination (GO:0006449)3.13856810
27intracellular estrogen receptor signaling pathway (GO:0030520)3.10711677
28neuromuscular process controlling balance (GO:0050885)3.08787474
29negative regulation of cell size (GO:0045792)3.07614650
30DNA unwinding involved in DNA replication (GO:0006268)3.07435779
31locomotory exploration behavior (GO:0035641)3.06492996
32peptidyl-tyrosine autophosphorylation (GO:0038083)3.02883819
33cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.01188445
34positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.98119780
35glial cell proliferation (GO:0014009)2.96713479
36regulation of glucose import in response to insulin stimulus (GO:2001273)2.90614617
37regulation of ARF GTPase activity (GO:0032312)2.90377754
38amino acid import (GO:0043090)2.89538517
39adherens junction assembly (GO:0034333)2.89484285
40protein localization to endosome (GO:0036010)2.89305259
41activation of Rac GTPase activity (GO:0032863)2.88703582
42cytoplasmic mRNA processing body assembly (GO:0033962)2.88358287
43activation of MAPKKK activity (GO:0000185)2.87854913
44apoptotic process involved in morphogenesis (GO:0060561)2.86917303
45synaptic vesicle maturation (GO:0016188)2.84484394
46regulation of hippo signaling (GO:0035330)2.84186927
47negative regulation of histone methylation (GO:0031061)2.83999506
48regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.82933789
49peptidyl-arginine omega-N-methylation (GO:0035247)2.82681225
50mating behavior (GO:0007617)2.80690057
51negative regulation of fatty acid transport (GO:2000192)2.78541543
52regulation of neuronal synaptic plasticity (GO:0048168)2.78264322
53planar cell polarity pathway involved in neural tube closure (GO:0090179)2.77554529
54proline biosynthetic process (GO:0006561)2.76673341
55regulation of early endosome to late endosome transport (GO:2000641)2.76453963
56regulation of mammary gland epithelial cell proliferation (GO:0033599)2.75920692
57regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.75785333
58mitochondrion transport along microtubule (GO:0047497)2.75465997
59establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.75465997
60NLS-bearing protein import into nucleus (GO:0006607)2.73586986
61regulation of nucleobase-containing compound transport (GO:0032239)2.73489644
62synaptic vesicle exocytosis (GO:0016079)2.73342413
63convergent extension (GO:0060026)2.72002932
64negative regulation of erythrocyte differentiation (GO:0045647)2.70000692
65positive regulation of RNA splicing (GO:0033120)2.68589652
66regulation of RNA export from nucleus (GO:0046831)2.67654627
67negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.67158722
68epithelial cell differentiation involved in prostate gland development (GO:0060742)2.66898580
69corticosteroid receptor signaling pathway (GO:0031958)2.66116725
70apical protein localization (GO:0045176)2.66073353
71positive regulation of protein deacetylation (GO:0090312)2.64283355
72establishment of mitochondrion localization (GO:0051654)2.63868580
73cell migration in hindbrain (GO:0021535)2.62779287
74dopamine receptor signaling pathway (GO:0007212)2.62240728
75positive regulation of gene expression, epigenetic (GO:0045815)2.61745808
76cortical actin cytoskeleton organization (GO:0030866)2.61180828
77establishment of apical/basal cell polarity (GO:0035089)2.60778313
78regulation of cholesterol biosynthetic process (GO:0045540)2.60690056
79peptidyl-arginine N-methylation (GO:0035246)2.59066121
80peptidyl-arginine methylation (GO:0018216)2.59066121
81Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.58908194
82receptor catabolic process (GO:0032801)2.55949618
83establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.55484041
84positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.55331468
85cerebellar Purkinje cell layer development (GO:0021680)2.54329366
86semaphorin-plexin signaling pathway (GO:0071526)2.54226050
87stress fiber assembly (GO:0043149)2.53137254
88neuronal ion channel clustering (GO:0045161)2.51847370
89maternal placenta development (GO:0001893)2.51444971
90establishment of nucleus localization (GO:0040023)2.49826529
91spliceosomal tri-snRNP complex assembly (GO:0000244)2.49594585
92RNA stabilization (GO:0043489)2.48523036
93mRNA stabilization (GO:0048255)2.48523036
94protein targeting to plasma membrane (GO:0072661)2.47933780
95L-amino acid import (GO:0043092)2.46480937
96cell junction maintenance (GO:0034331)2.46327031
97negative regulation of microtubule polymerization (GO:0031115)2.44474520
98vocalization behavior (GO:0071625)2.44358149
99regulation of establishment of planar polarity (GO:0090175)2.44055832
100negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.42924726
101cellular sodium ion homeostasis (GO:0006883)2.41941820
102glucose 6-phosphate metabolic process (GO:0051156)2.41660032
103regulation of synaptic vesicle transport (GO:1902803)2.40796691
104dosage compensation (GO:0007549)2.40184240
105positive regulation of dendritic spine morphogenesis (GO:0061003)2.39870043
106positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.39787125
107regulation of ARF protein signal transduction (GO:0032012)2.39712216
108positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.39259560
109regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.39259560
110signal complex assembly (GO:0007172)2.38925335
111establishment or maintenance of bipolar cell polarity (GO:0061245)2.38770004
112establishment or maintenance of apical/basal cell polarity (GO:0035088)2.38770004
113neurotransmitter secretion (GO:0007269)2.38537002
114regulation of glutamate receptor signaling pathway (GO:1900449)2.38043711
115establishment of monopolar cell polarity (GO:0061162)2.37238184
116establishment or maintenance of monopolar cell polarity (GO:0061339)2.37238184
117epithelial cell-cell adhesion (GO:0090136)2.37122967
118mitotic chromosome condensation (GO:0007076)2.37088843
119thymic T cell selection (GO:0045061)2.37072017
120activation of JUN kinase activity (GO:0007257)2.36380369
121hippo signaling (GO:0035329)2.35965037
122stress granule assembly (GO:0034063)2.35377523
123regulation of histone H3-K27 methylation (GO:0061085)2.35297305
124mitotic G1 DNA damage checkpoint (GO:0031571)2.34607023
125camera-type eye morphogenesis (GO:0048593)2.34175911
126ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.33690405
127regulation of chromatin binding (GO:0035561)2.33575900
128neural tube development (GO:0021915)2.33467238
129focal adhesion assembly (GO:0048041)2.31929087
130cell-substrate adherens junction assembly (GO:0007045)2.31929087
131labyrinthine layer blood vessel development (GO:0060716)2.31382784
132cellular response to epidermal growth factor stimulus (GO:0071364)2.29782501
133negative regulation of RNA splicing (GO:0033119)2.28927144
134protein-DNA complex disassembly (GO:0032986)2.27775595
135nucleosome disassembly (GO:0006337)2.27775595
136clathrin coat assembly (GO:0048268)2.26360074
137positive thymic T cell selection (GO:0045059)2.26032510
138cellular response to nerve growth factor stimulus (GO:1990090)2.24957161
139response to nerve growth factor (GO:1990089)2.24957161
140lens fiber cell development (GO:0070307)2.24940663
141cell-substrate junction assembly (GO:0007044)2.22151597
142response to epidermal growth factor (GO:0070849)2.20743838
143natural killer cell differentiation (GO:0001779)2.20674078
144negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.20481448
145negative regulation of cell killing (GO:0031342)2.20481448
146G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.20379134
147negative regulation of nucleotide catabolic process (GO:0030812)2.20265164
148L-serine transport (GO:0015825)2.19526509
149negative regulation of GTPase activity (GO:0034260)2.19072755
150negative regulation of GTP catabolic process (GO:0033125)2.19072755
151negative regulation of catenin import into nucleus (GO:0035414)2.18792717
152regulation of gamma-delta T cell differentiation (GO:0045586)2.18692197
153activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.18062522
154insulin-like growth factor receptor signaling pathway (GO:0048009)2.17342327
155negative regulation of mRNA metabolic process (GO:1903312)2.17038025
156apoptotic process involved in development (GO:1902742)2.16958784
157positive regulation of dendrite morphogenesis (GO:0050775)2.16915439
158regulation of posttranscriptional gene silencing (GO:0060147)2.16037073
159regulation of gene silencing by miRNA (GO:0060964)2.16037073
160regulation of gene silencing by RNA (GO:0060966)2.16037073
161actin filament bundle organization (GO:0061572)2.14785692

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human3.87259450
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.71387571
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.69610761
4KDM2B_26808549_Chip-Seq_DND41_Human2.89239031
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.85764893
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.85398389
7E2F7_22180533_ChIP-Seq_HELA_Human2.84565044
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.83825395
9KDM2B_26808549_Chip-Seq_SUP-B15_Human2.82269278
10* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.62888354
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.60404720
12VDR_21846776_ChIP-Seq_THP-1_Human2.58095769
13TCF7_22412390_ChIP-Seq_EML_Mouse2.56586048
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.53613710
15KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.49906858
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.28183673
17* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.23606168
18* LXR_22292898_ChIP-Seq_THP-1_Human2.17918534
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.16791318
20KDM2B_26808549_Chip-Seq_K562_Human2.11865729
21KDM2B_26808549_Chip-Seq_JURKAT_Human2.10477546
22ZNF263_19887448_ChIP-Seq_K562_Human2.09294842
23* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.04354871
24P300_27058665_Chip-Seq_ZR-75-30cells_Human1.83047757
25RACK7_27058665_Chip-Seq_MCF-7_Human1.80366043
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.77077848
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77064725
28DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.74183546
29SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.73341331
30MAF_26560356_Chip-Seq_TH1_Human1.69705462
31KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.66443135
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.65636840
33* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.65290245
34UTX_26944678_Chip-Seq_JUKART_Human1.64087073
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.62490467
36* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.57653805
37EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.53292145
38ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.52702365
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52585071
40DNAJC2_21179169_ChIP-ChIP_NT2_Human1.52127983
41RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.51193067
42CREB1_26743006_Chip-Seq_LNCaP_Human1.50139613
43* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.49963697
44SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.44830876
45* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.41407539
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41094022
47RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.40482214
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38328889
49UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38108656
50GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37843950
51* VDR_24763502_ChIP-Seq_THP-1_Human1.37538819
52* ATF3_27146783_Chip-Seq_COLON_Human1.37156630
53RARB_27405468_Chip-Seq_BRAIN_Mouse1.35132895
54SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34772704
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.34727920
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33295976
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31645010
58CLOCK_20551151_ChIP-Seq_293T_Human1.28029763
59TP53_22127205_ChIP-Seq_IMR90_Human1.27872084
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27856163
61NCOR1_26117541_ChIP-Seq_K562_Human1.27203420
62EZH2_22144423_ChIP-Seq_EOC_Human1.25822173
63CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24498088
64P68_20966046_ChIP-Seq_HELA_Human1.23957282
65CTCF_27219007_Chip-Seq_Bcells_Human1.23948606
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22623695
67PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.22595973
68ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22170917
69TET1_21451524_ChIP-Seq_MESCs_Mouse1.21235356
70* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18723931
71EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.17251464
72ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16944052
73RUNX1_27514584_Chip-Seq_MCF-7_Human1.16777399
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16644241
75* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16508119
76* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.15921365
77* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.14738912
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14444473
79PKCTHETA_26484144_Chip-Seq_BREAST_Human1.13995734
80RNF2_18974828_ChIP-Seq_MESCs_Mouse1.13420167
81EZH2_18974828_ChIP-Seq_MESCs_Mouse1.13420167
82SPI1_23127762_ChIP-Seq_K562_Human1.12623196
83CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12401671
84SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.11967510
85SCL_19346495_ChIP-Seq_HPC-7_Human1.11135038
86NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10794037
87SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10166697
88IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09548356
89TET1_21490601_ChIP-Seq_MESCs_Mouse1.09134071
90* MAF_26560356_Chip-Seq_TH2_Human1.07795428
91DROSHA_22980978_ChIP-Seq_HELA_Human1.07391820
92MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07374377
93SA1_27219007_Chip-Seq_ERYTHROID_Human1.07278918
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06350714
95CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06015786
96RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06001828
97ESR2_21235772_ChIP-Seq_MCF-7_Human1.05758775
98CIITA_25753668_ChIP-Seq_RAJI_Human1.05683568
99ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05586945
100* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.05124535
101CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04957568
102* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02893826
103ELF1_20517297_ChIP-Seq_JURKAT_Human1.02362653
104ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02304327
105RNF2_27304074_Chip-Seq_ESCs_Mouse1.02169701
106SMC4_20622854_ChIP-Seq_HELA_Human1.02026751
107SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.01487470
108MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.01293698
109NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.01233988
110GATA1_19941826_ChIP-Seq_K562_Human1.00004821
111SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99592958
112NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99272265
113* NANOG_21062744_ChIP-ChIP_HESCs_Human0.96580717
114* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95936326
115* GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.95579812
116KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94924498
117* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93273397
118PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92594994
119ERG_21242973_ChIP-ChIP_JURKAT_Human0.92539116
120JARID2_20075857_ChIP-Seq_MESCs_Mouse0.92142972
121FOXO3_23340844_ChIP-Seq_DLD1_Human0.91659992
122CHD1_26751641_Chip-Seq_LNCaP_Human0.91323484
123* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91011794
124* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.90058116
125POU5F1_16518401_ChIP-PET_MESCs_Mouse0.89211854
126TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89108155
127* RUNX1_22412390_ChIP-Seq_EML_Mouse0.87714085

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.87943531
2MP0000566_synostosis3.57448369
3MP0005076_abnormal_cell_differentiation3.30772060
4MP0010352_gastrointestinal_tract_polyps3.15508765
5MP0003300_gastrointestinal_ulcer3.01043596
6MP0004859_abnormal_synaptic_plasticity2.78062191
7MP0004858_abnormal_nervous_system2.77334010
8MP0005409_darkened_coat_color2.68425917
9MP0003303_peritoneal_inflammation2.65852422
10MP0010234_abnormal_vibrissa_follicle2.62774059
11MP0005423_abnormal_somatic_nervous2.44531513
12MP0009278_abnormal_bone_marrow2.41435258
13MP0008961_abnormal_basal_metabolism2.36418098
14MP0005623_abnormal_meninges_morphology2.29459642
15MP0003283_abnormal_digestive_organ2.25074077
16MP0000537_abnormal_urethra_morphology2.22020281
17MP0001849_ear_inflammation2.15314785
18MP0000579_abnormal_nail_morphology2.02655028
19MP0001348_abnormal_lacrimal_gland2.02648191
20MP0002653_abnormal_ependyma_morphology1.98755046
21MP0002089_abnormal_postnatal_growth/wei1.78783878
22MP0003566_abnormal_cell_adhesion1.77723811
23MP0002249_abnormal_larynx_morphology1.75523236
24MP0002877_abnormal_melanocyte_morpholog1.74235894
25MP0000733_abnormal_muscle_development1.71136687
26MP0003091_abnormal_cell_migration1.70558305
27MP0003329_amyloid_beta_deposits1.68398353
28MP0000678_abnormal_parathyroid_gland1.66852776
29MP0005451_abnormal_body_composition1.66771161
30MP0000569_abnormal_digit_pigmentation1.63831337
31MP0004197_abnormal_fetal_growth/weight/1.61701327
32MP0002063_abnormal_learning/memory/cond1.54609858
33MP0004264_abnormal_extraembryonic_tissu1.52356412
34MP0010030_abnormal_orbit_morphology1.48741918
35MP0005257_abnormal_intraocular_pressure1.48049274
36MP0009780_abnormal_chondrocyte_physiolo1.47780541
37MP0002084_abnormal_developmental_patter1.46250020
38MP0001730_embryonic_growth_arrest1.45217854
39MP0003115_abnormal_respiratory_system1.42276029
40MP0002822_catalepsy1.41308000
41MP0003634_abnormal_glial_cell1.39078536
42MP0003119_abnormal_digestive_system1.34598695
43MP0000428_abnormal_craniofacial_morphol1.33141702
44MP0002234_abnormal_pharynx_morphology1.32855569
45MP0004808_abnormal_hematopoietic_stem1.32431885
46MP0004233_abnormal_muscle_weight1.31095369
47MP0000534_abnormal_ureter_morphology1.28906943
48MP0001346_abnormal_lacrimal_gland1.24128480
49MP0004885_abnormal_endolymph1.24086367
50MP0008770_decreased_survivor_rate1.22641103
51MP0000350_abnormal_cell_proliferation1.22628413
52MP0004947_skin_inflammation1.22619023
53MP0010307_abnormal_tumor_latency1.21469379
54MP0002085_abnormal_embryonic_tissue1.19132737
55MP0002064_seizures1.17781536
56MP0000685_abnormal_immune_system1.17652624
57MP0002796_impaired_skin_barrier1.17350663
58MP0005023_abnormal_wound_healing1.16145745
59MP0002734_abnormal_mechanical_nocicepti1.13467610
60MP0003861_abnormal_nervous_system1.12413600
61MP0002086_abnormal_extraembryonic_tissu1.10600139
62MP0004811_abnormal_neuron_physiology1.09145873
63MP0003045_fibrosis1.08017649
64MP0003123_paternal_imprinting1.07236181
65MP0000703_abnormal_thymus_morphology1.02189793
66MP0001697_abnormal_embryo_size1.01767406
67MP0002080_prenatal_lethality1.01182753
68MP0002925_abnormal_cardiovascular_devel1.00836526
69MP0002909_abnormal_adrenal_gland0.99697957
70MP0004272_abnormal_basement_membrane0.98800946
71MP0000751_myopathy0.98120004
72MP0005666_abnormal_adipose_tissue0.97456556
73MP0000462_abnormal_digestive_system0.97156228
74MP0000003_abnormal_adipose_tissue0.96920401
75MP0003172_abnormal_lysosome_physiology0.96341557
76MP0003942_abnormal_urinary_system0.96117973
77MP0003635_abnormal_synaptic_transmissio0.95668460
78MP0010630_abnormal_cardiac_muscle0.94841702
79MP0003880_abnormal_central_pattern0.94288202
80MP0005380_embryogenesis_phenotype0.93515622
81MP0001672_abnormal_embryogenesis/_devel0.93515622
82MP0001915_intracranial_hemorrhage0.92678116
83MP0002088_abnormal_embryonic_growth/wei0.92135255
84MP0002092_abnormal_eye_morphology0.92133685
85MP0003866_abnormal_defecation0.91561736
86MP0004510_myositis0.91199169
87MP0003279_aneurysm0.91155591
88MP0003984_embryonic_growth_retardation0.91054551
89MP0001958_emphysema0.90756690
90MP0000955_abnormal_spinal_cord0.90738632
91MP0002396_abnormal_hematopoietic_system0.90459586
92MP0008260_abnormal_autophagy0.89686255
93MP0009053_abnormal_anal_canal0.89642981
94MP0009840_abnormal_foam_cell0.89640834
95MP0004185_abnormal_adipocyte_glucose0.88532091
96MP0003453_abnormal_keratinocyte_physiol0.88338847
97MP0005501_abnormal_skin_physiology0.88101165
98MP0000604_amyloidosis0.87502454
99MP0004270_analgesia0.87168661
100MP0005058_abnormal_lysosome_morphology0.87084155
101MP0002009_preneoplasia0.86886280
102MP0005397_hematopoietic_system_phenotyp0.86750809
103MP0001545_abnormal_hematopoietic_system0.86750809
104MP0000778_abnormal_nervous_system0.86587691
105MP0002882_abnormal_neuron_morphology0.86001034
106MP0002697_abnormal_eye_size0.85896267
107MP0002572_abnormal_emotion/affect_behav0.85145288
108MP0006054_spinal_hemorrhage0.84258627
109MP0009672_abnormal_birth_weight0.84044254
110MP0002184_abnormal_innervation0.83568209
111MP0003111_abnormal_nucleus_morphology0.83545740
112MP0005394_taste/olfaction_phenotype0.82137490
113MP0005499_abnormal_olfactory_system0.82137490
114MP0002398_abnormal_bone_marrow0.81311630
115MP0010678_abnormal_skin_adnexa0.81137752
116MP0009703_decreased_birth_body0.80331765
117MP0002152_abnormal_brain_morphology0.80274458
118MP0000920_abnormal_myelination0.78401626
119MP0002116_abnormal_craniofacial_bone0.78388120
120MP0003935_abnormal_craniofacial_develop0.78236267
121MP0005375_adipose_tissue_phenotype0.77697501
122MP0002098_abnormal_vibrissa_morphology0.77332470
123MP0003879_abnormal_hair_cell0.76133800
124MP0003385_abnormal_body_wall0.75760422
125MP0001943_abnormal_respiration0.75313150
126MP0000477_abnormal_intestine_morphology0.75074301
127MP0010769_abnormal_survival0.74918808
128MP0008569_lethality_at_weaning0.73986500
129MP0002066_abnormal_motor_capabilities/c0.73719113
130MP0001502_abnormal_circadian_rhythm0.73304196
131MP0010770_preweaning_lethality0.72315440
132MP0001784_abnormal_fluid_regulation0.71679629
133MP0003121_genomic_imprinting0.70864245
134MP0001293_anophthalmia0.70586497
135MP0002081_perinatal_lethality0.70342351
136MP0005621_abnormal_cell_physiology0.70277632
137MP0001299_abnormal_eye_distance/0.70079251
138MP0005187_abnormal_penis_morphology0.69757393
139MP0000467_abnormal_esophagus_morphology0.69569558
140MP0002111_abnormal_tail_morphology0.69408936
141MP0003122_maternal_imprinting0.66566062

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.89316179
2Obstructive sleep apnea (HP:0002870)3.09697639
3Insomnia (HP:0100785)3.01375723
4Shallow orbits (HP:0000586)2.99797964
5Cerebral aneurysm (HP:0004944)2.73187758
6Neurofibrillary tangles (HP:0002185)2.67573660
7Short 4th metacarpal (HP:0010044)2.67217244
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.67217244
9Distal upper limb amyotrophy (HP:0007149)2.66762437
10Upper limb amyotrophy (HP:0009129)2.66762437
11Macroorchidism (HP:0000053)2.64930235
12Overriding aorta (HP:0002623)2.63536885
13Pointed chin (HP:0000307)2.57327354
14Renal duplication (HP:0000075)2.55979865
15Elfin facies (HP:0004428)2.55177726
16Astrocytoma (HP:0009592)2.51745987
17Abnormality of the astrocytes (HP:0100707)2.51745987
18Bowel diverticulosis (HP:0005222)2.48839929
19Broad face (HP:0000283)2.47001143
20Increased density of long bones (HP:0006392)2.46633162
21Abnormality of the lower motor neuron (HP:0002366)2.44427212
22Heterotopia (HP:0002282)2.44079217
23Hand muscle atrophy (HP:0009130)2.40560042
24Ankyloglossia (HP:0010296)2.37300639
25Protrusio acetabuli (HP:0003179)2.36820732
26Ependymoma (HP:0002888)2.36150906
27Ankle clonus (HP:0011448)2.34499198
28Renovascular hypertension (HP:0100817)2.33118385
29Increased nuchal translucency (HP:0010880)2.32580047
30Hammertoe (HP:0001765)2.32105736
31Flat acetabular roof (HP:0003180)2.31468587
32Cerebral inclusion bodies (HP:0100314)2.29647130
33Genu recurvatum (HP:0002816)2.25792782
34Abnormality of oral frenula (HP:0000190)2.24599154
35Myokymia (HP:0002411)2.22218380
36Ulnar bowing (HP:0003031)2.21623579
37Bladder diverticulum (HP:0000015)2.18077964
38Pseudobulbar signs (HP:0002200)2.15539834
39Supranuclear gaze palsy (HP:0000605)2.15117276
40Aplasia involving bones of the extremities (HP:0009825)2.14759213
41Aplasia involving bones of the upper limbs (HP:0009823)2.14759213
42Aplasia of the phalanges of the hand (HP:0009802)2.14759213
43Abnormality of the fingertips (HP:0001211)2.12331347
44Cholecystitis (HP:0001082)2.08207001
45Abnormal gallbladder physiology (HP:0012438)2.08207001
46Peripheral hypomyelination (HP:0007182)2.08073939
47Neoplasm of the heart (HP:0100544)2.06747029
48Termporal pattern (HP:0011008)2.05173679
49Insidious onset (HP:0003587)2.05173679
50Advanced eruption of teeth (HP:0006288)2.05109633
51Abnormality of the distal phalanx of the thumb (HP:0009617)2.03980887
52Asymmetry of the thorax (HP:0001555)2.03879905
53Precocious puberty (HP:0000826)2.02872916
54Megalencephaly (HP:0001355)2.01293116
55Trigonocephaly (HP:0000243)2.00775154
56Ankle contracture (HP:0006466)1.99423217
57Apathy (HP:0000741)1.99291848
58Abnormality of the 4th metacarpal (HP:0010012)1.97985431
59Flat cornea (HP:0007720)1.97364620
60Enlarged penis (HP:0000040)1.96587802
61Hallux valgus (HP:0001822)1.96394710
62Vertebral arch anomaly (HP:0008438)1.95459657
63Deviation of the hallux (HP:0010051)1.95236784
64Dilatation of the ascending aorta (HP:0005111)1.93236396
65Mitral valve prolapse (HP:0001634)1.90958796
66Neuronal loss in central nervous system (HP:0002529)1.90248074
67Thin ribs (HP:0000883)1.89865980
68Annular pancreas (HP:0001734)1.89739983
69Fibroma (HP:0010614)1.88420415
70Hypercortisolism (HP:0001578)1.86844393
71Generalized hypotonia (HP:0001290)1.85738149
72Achilles tendon contracture (HP:0001771)1.85717394
73Diminished motivation (HP:0000745)1.84498889
74Abnormality of the salivary glands (HP:0010286)1.82238724
75Fibrous tissue neoplasm (HP:0012316)1.81759582
76Subacute progressive viral hepatitis (HP:0006572)1.81748415
77Bowel incontinence (HP:0002607)1.81375562
78Turricephaly (HP:0000262)1.81278341
79Arnold-Chiari malformation (HP:0002308)1.81044238
80Amyotrophic lateral sclerosis (HP:0007354)1.80841786
81Deviation of the thumb (HP:0009603)1.79965854
82Proximal placement of thumb (HP:0009623)1.78191107
83Broad metatarsal (HP:0001783)1.78049840
84Centrally nucleated skeletal muscle fibers (HP:0003687)1.75840931
85Patellar dislocation (HP:0002999)1.75500448
86Deep venous thrombosis (HP:0002625)1.75439023
87Broad palm (HP:0001169)1.75259767
88Depression (HP:0000716)1.75047552
89High anterior hairline (HP:0009890)1.74848889
90Distal lower limb amyotrophy (HP:0008944)1.73834413
91Germ cell neoplasia (HP:0100728)1.73830297
92Lower limb amyotrophy (HP:0007210)1.73599889
93Cortical dysplasia (HP:0002539)1.72116608
94Reticulocytosis (HP:0001923)1.71388083
95Bowing of the arm (HP:0006488)1.71003715
96Bowed forearm bones (HP:0003956)1.71003715
97Disproportionate tall stature (HP:0001519)1.69773087
98Obsessive-compulsive behavior (HP:0000722)1.69249170
99Lower limb asymmetry (HP:0100559)1.68274619
100Neonatal short-limb short stature (HP:0008921)1.67831246
101Back pain (HP:0003418)1.67504959
102Large earlobe (HP:0009748)1.67132703
103Megalocornea (HP:0000485)1.66895187
104Abnormality of the diencephalon (HP:0010662)1.66202087
105Broad thumb (HP:0011304)1.65907815
106Abnormality of the thoracic spine (HP:0100711)1.65248466
107Long palpebral fissure (HP:0000637)1.63397298
108Relative macrocephaly (HP:0004482)1.63393579
109Basal cell carcinoma (HP:0002671)1.62574563
110Decreased motor nerve conduction velocity (HP:0003431)1.62390623
111Spina bifida occulta (HP:0003298)1.61972807
112Thin bony cortex (HP:0002753)1.61901477
113Distal sensory impairment (HP:0002936)1.60708860
114Aneurysm (HP:0002617)1.59962642
115Glioma (HP:0009733)1.59175258
116Abnormal large intestine physiology (HP:0012700)1.58808950
117Hyperparathyroidism (HP:0000843)1.58781577
118Gastrointestinal carcinoma (HP:0002672)1.58452714
119Malignant gastrointestinal tract tumors (HP:0006749)1.58452714
120Interstitial pulmonary disease (HP:0006530)1.58366370
121Buphthalmos (HP:0000557)1.58208328
122Abnormality of the Achilles tendon (HP:0005109)1.58106269
123Urethral obstruction (HP:0000796)1.57886347
124Metaphyseal cupping (HP:0003021)1.57690283
125Skin tags (HP:0010609)1.57510869
126Alacrima (HP:0000522)1.56983724
127Cellulitis (HP:0100658)1.56954100
128Striae distensae (HP:0001065)1.55855292
129Sacral dimple (HP:0000960)1.55770886
130Radial bowing (HP:0002986)1.55627743
131Persistence of primary teeth (HP:0006335)1.55520029
132Long eyelashes (HP:0000527)1.54686464
133Abnormality of the aortic arch (HP:0012303)1.54399721
134Tracheomalacia (HP:0002779)1.54296332
135Truncus arteriosus (HP:0001660)1.53923363
136Deep palmar crease (HP:0006191)1.53593569
137Thickened helices (HP:0000391)1.53569855
138Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.53491262
139Peritonitis (HP:0002586)1.53404086
140Attention deficit hyperactivity disorder (HP:0007018)1.52131990
141Choanal stenosis (HP:0000452)1.51719787
142Hypercalcemia (HP:0003072)1.50656530
143Dysmetric saccades (HP:0000641)1.49522655
144Spastic gait (HP:0002064)1.49408566
145Bronchomalacia (HP:0002780)1.47751738
146Urinary urgency (HP:0000012)1.47443667
147Resting tremor (HP:0002322)1.46976756
148Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.44195386
149Papilledema (HP:0001085)1.43846177
150Short phalanx of the thumb (HP:0009660)1.43536590
151Overlapping toe (HP:0001845)1.43008735
152Abnormality of the peritoneum (HP:0002585)1.42987674
153Neoplasm of the oral cavity (HP:0100649)1.42792065

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.56291857
2TRIB34.16062987
3PRPF4B3.27750232
4MAP3K103.24142449
5PKN23.23448203
6SMG13.23418074
7CDK122.89490100
8MAP3K92.14242647
9ICK2.06902506
10ALK1.98952329
11SIK11.94322286
12PTK61.79696113
13SIK21.78727120
14MAP4K11.77966409
15TYRO31.74202055
16LRRK21.66507119
17PDGFRA1.64207911
18ERN11.62792136
19RIPK11.62735784
20BMX1.61018671
21KSR21.57496295
22SCYL21.50558431
23TAOK11.48037865
24PRKD31.43109633
25PAK61.39035664
26MTOR1.24197190
27EPHB11.24173395
28RET1.19553897
29NTRK31.18936032
30NTRK11.18235579
31GRK61.17604931
32MARK11.13299570
33STK101.12892405
34LATS21.12540593
35CAMKK11.06889115
36ARAF1.06429110
37TESK21.05773869
38MAP3K131.05219187
39PAK21.04946195
40TTN1.04747298
41PAK41.04740722
42PTK21.03840150
43MARK21.02588387
44DDR21.00961011
45EPHA41.00476266
46CAMK1G0.96362677
47PASK0.96067923
48NEK20.93023291
49PDGFRB0.91575343
50NTRK20.91559170
51BRD40.87127255
52RPS6KB20.86550490
53UHMK10.83861324
54MAP3K70.83476024
55FGFR40.82653057
56FGFR10.80996574
57PRKCH0.79926899
58KSR10.77827181
59MAP3K80.77305811
60CDC70.74972849
61MAP3K20.74650542
62DMPK0.74465453
63CAMK1D0.72622989
64BRAF0.72394909
65CDK60.71176020
66SGK30.68334559
67SGK2230.67200373
68SGK4940.67200373
69PDPK10.64126031
70MAPK100.61880597
71RPS6KA20.61536046
72RIPK40.61500090
73JAK30.61020126
74IRAK30.60825566
75MINK10.60040745
76CDK40.59531117
77CLK10.58977023
78CDK150.58645196
79HIPK20.58320309
80HCK0.57711000
81CDK11A0.56305331
82CSF1R0.55585291
83WNK10.54889857
84FGFR20.54014549
85CDK140.53865480
86DAPK20.52130282
87CDK180.51774577
88EPHA20.51457417
89TGFBR10.51031099
90FGFR30.50314513
91NEK10.49600199
92ILK0.49065266
93RPS6KA10.48758769
94MAPK110.48696965
95MAP3K10.48691703
96FGR0.48539748
97CDC42BPA0.47625678
98MAPK120.47584827
99STK110.47462377
100TESK10.47364723
101ROCK20.46757318
102CDK70.46509316
103RPS6KL10.46329659
104RPS6KC10.46329659
105CDK50.45688799
106PRKD20.45225764
107LMTK20.44247321
108ZAP700.43778885
109FLT30.43600896
110AKT20.43227830
111TAOK20.43032791
112MAP2K20.42045738
113DYRK1B0.41720676
114CSNK1D0.41571607
115PAK30.41514014
116CHEK10.41265249
117PDK10.40955767
118EPHB20.40642184
119CHUK0.40115782
120RAF10.39765865
121SRC0.39684807
122CDK20.39368619
123FYN0.37756803
124ERBB20.37009346
125GSK3B0.36805158
126MAPK90.36520054
127MAPK80.34927232
128CAMK40.33369810
129PRKAA10.33080674
130MET0.31333359

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.16668757
2Chronic myeloid leukemia_Homo sapiens_hsa052201.96935490
3Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.71274132
4Glioma_Homo sapiens_hsa052141.66054164
5Neurotrophin signaling pathway_Homo sapiens_hsa047221.62014835
6mTOR signaling pathway_Homo sapiens_hsa041501.61511645
7Non-small cell lung cancer_Homo sapiens_hsa052231.59057334
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.57238452
9Prion diseases_Homo sapiens_hsa050201.54223935
10B cell receptor signaling pathway_Homo sapiens_hsa046621.52220552
11Endometrial cancer_Homo sapiens_hsa052131.49348358
12Cyanoamino acid metabolism_Homo sapiens_hsa004601.47794297
13Notch signaling pathway_Homo sapiens_hsa043301.47570222
14Colorectal cancer_Homo sapiens_hsa052101.46828994
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46414034
16VEGF signaling pathway_Homo sapiens_hsa043701.44979260
17Central carbon metabolism in cancer_Homo sapiens_hsa052301.42896677
18Synaptic vesicle cycle_Homo sapiens_hsa047211.40889402
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.36796459
20Proteoglycans in cancer_Homo sapiens_hsa052051.35948138
21Estrogen signaling pathway_Homo sapiens_hsa049151.32735031
22Renal cell carcinoma_Homo sapiens_hsa052111.32356567
23Pancreatic cancer_Homo sapiens_hsa052121.30040559
24MicroRNAs in cancer_Homo sapiens_hsa052061.28552934
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.28174515
26Acute myeloid leukemia_Homo sapiens_hsa052211.28093925
27Biosynthesis of amino acids_Homo sapiens_hsa012301.26898273
28Thyroid hormone signaling pathway_Homo sapiens_hsa049191.25216415
29Bladder cancer_Homo sapiens_hsa052191.24643889
30Dorso-ventral axis formation_Homo sapiens_hsa043201.23357706
31ErbB signaling pathway_Homo sapiens_hsa040121.21236197
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.19126555
33Steroid biosynthesis_Homo sapiens_hsa001001.17585441
34AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17509032
35T cell receptor signaling pathway_Homo sapiens_hsa046601.16848851
36Hippo signaling pathway_Homo sapiens_hsa043901.16360123
37Basal cell carcinoma_Homo sapiens_hsa052171.14469343
38Focal adhesion_Homo sapiens_hsa045101.12140260
39Adherens junction_Homo sapiens_hsa045201.06163756
40Axon guidance_Homo sapiens_hsa043601.06120304
41Nitrogen metabolism_Homo sapiens_hsa009101.06055246
42Type II diabetes mellitus_Homo sapiens_hsa049301.05729353
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05120457
44Small cell lung cancer_Homo sapiens_hsa052221.04058703
45Prolactin signaling pathway_Homo sapiens_hsa049171.03802027
46Gap junction_Homo sapiens_hsa045401.02710884
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02422754
48Shigellosis_Homo sapiens_hsa051310.98246160
49Amphetamine addiction_Homo sapiens_hsa050310.97539752
50HTLV-I infection_Homo sapiens_hsa051660.97410006
51Inositol phosphate metabolism_Homo sapiens_hsa005620.96938396
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.96836044
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96591757
54Long-term potentiation_Homo sapiens_hsa047200.96103029
55Vitamin B6 metabolism_Homo sapiens_hsa007500.95896226
56Viral myocarditis_Homo sapiens_hsa054160.95737300
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95230055
58Hedgehog signaling pathway_Homo sapiens_hsa043400.93598562
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.93289943
60Fatty acid biosynthesis_Homo sapiens_hsa000610.93152216
61Thyroid cancer_Homo sapiens_hsa052160.93023616
62GnRH signaling pathway_Homo sapiens_hsa049120.92662868
63Regulation of actin cytoskeleton_Homo sapiens_hsa048100.92541571
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92477497
65Endocytosis_Homo sapiens_hsa041440.92366715
66Platelet activation_Homo sapiens_hsa046110.90903044
67Gastric acid secretion_Homo sapiens_hsa049710.90636949
68Thyroid hormone synthesis_Homo sapiens_hsa049180.90424137
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90309934
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90121608
71Melanogenesis_Homo sapiens_hsa049160.89852181
72Bile secretion_Homo sapiens_hsa049760.88722278
73Rap1 signaling pathway_Homo sapiens_hsa040150.88143755
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87954545
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86488191
76Glutamatergic synapse_Homo sapiens_hsa047240.85998801
77Pentose phosphate pathway_Homo sapiens_hsa000300.85825994
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85027892
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84399824
80Toxoplasmosis_Homo sapiens_hsa051450.83328465
81MAPK signaling pathway_Homo sapiens_hsa040100.82692983
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81718049
83Lysine degradation_Homo sapiens_hsa003100.81208936
84Fructose and mannose metabolism_Homo sapiens_hsa000510.81177972
85Insulin signaling pathway_Homo sapiens_hsa049100.80558534
86Chemokine signaling pathway_Homo sapiens_hsa040620.80419026
87Osteoclast differentiation_Homo sapiens_hsa043800.79314857
88Hepatitis B_Homo sapiens_hsa051610.79157259
89Amoebiasis_Homo sapiens_hsa051460.79049796
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78979442
91Insulin resistance_Homo sapiens_hsa049310.78787532
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78696808
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78542614
94mRNA surveillance pathway_Homo sapiens_hsa030150.78452766
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77946933
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77853264
97Cholinergic synapse_Homo sapiens_hsa047250.77458268
98Glucagon signaling pathway_Homo sapiens_hsa049220.77313076
99Viral carcinogenesis_Homo sapiens_hsa052030.76088394
100Cocaine addiction_Homo sapiens_hsa050300.75838157
101Tight junction_Homo sapiens_hsa045300.75568194
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75441633
103Pathways in cancer_Homo sapiens_hsa052000.75186137
104Wnt signaling pathway_Homo sapiens_hsa043100.74453182
105Oxytocin signaling pathway_Homo sapiens_hsa049210.74341075
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74109688
107Insulin secretion_Homo sapiens_hsa049110.73916763
108Dopaminergic synapse_Homo sapiens_hsa047280.73867873
109Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72039591
110Nicotine addiction_Homo sapiens_hsa050330.71414524
111Choline metabolism in cancer_Homo sapiens_hsa052310.70547370
112HIF-1 signaling pathway_Homo sapiens_hsa040660.70506303
113Arginine biosynthesis_Homo sapiens_hsa002200.70095584
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69915370
115Long-term depression_Homo sapiens_hsa047300.69876691
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69811757
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.69411600
118Prostate cancer_Homo sapiens_hsa052150.68589711
119Circadian entrainment_Homo sapiens_hsa047130.68580109
120AMPK signaling pathway_Homo sapiens_hsa041520.68198086
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68084345
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67997334
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67575443
124Salivary secretion_Homo sapiens_hsa049700.67372901
125Vibrio cholerae infection_Homo sapiens_hsa051100.67031566
126Oocyte meiosis_Homo sapiens_hsa041140.66766272
127Apoptosis_Homo sapiens_hsa042100.66174610
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65839181
129Primary immunodeficiency_Homo sapiens_hsa053400.65655649
130Carbon metabolism_Homo sapiens_hsa012000.65614144
131ECM-receptor interaction_Homo sapiens_hsa045120.65492628
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62916115
133Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61874659
134GABAergic synapse_Homo sapiens_hsa047270.61790076
135Adipocytokine signaling pathway_Homo sapiens_hsa049200.60473812

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