SRFBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.61642495
2nucleobase biosynthetic process (GO:0046112)4.51666880
3purine nucleobase biosynthetic process (GO:0009113)4.40556241
4formation of translation preinitiation complex (GO:0001731)4.37762925
5mitotic metaphase plate congression (GO:0007080)4.35769539
6DNA replication initiation (GO:0006270)4.34926624
7maturation of SSU-rRNA (GO:0030490)4.32397417
8DNA strand elongation involved in DNA replication (GO:0006271)4.32044020
9ribosome assembly (GO:0042255)4.25169290
10DNA replication checkpoint (GO:0000076)4.24979411
11protein prenylation (GO:0018342)4.14876983
12prenylation (GO:0097354)4.14876983
13protein localization to kinetochore (GO:0034501)4.10693149
14DNA strand elongation (GO:0022616)4.09930639
15ribosome biogenesis (GO:0042254)4.09885587
16nuclear pore organization (GO:0006999)4.09180238
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.07311898
18mitotic nuclear envelope disassembly (GO:0007077)3.97897680
19DNA unwinding involved in DNA replication (GO:0006268)3.97857778
20nuclear pore complex assembly (GO:0051292)3.96055809
21establishment of protein localization to mitochondrial membrane (GO:0090151)3.92081154
22telomere maintenance via semi-conservative replication (GO:0032201)3.91055999
23IMP biosynthetic process (GO:0006188)3.90802335
24chromatin remodeling at centromere (GO:0031055)3.85376626
25DNA deamination (GO:0045006)3.82331378
26CENP-A containing nucleosome assembly (GO:0034080)3.81750426
27negative regulation of DNA-dependent DNA replication (GO:2000104)3.81059293
28exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.78080503
29nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.74661651
30respiratory chain complex IV assembly (GO:0008535)3.72375111
31ribonucleoprotein complex biogenesis (GO:0022613)3.71580121
32metaphase plate congression (GO:0051310)3.69427838
33double-strand break repair via nonhomologous end joining (GO:0006303)3.68945479
34non-recombinational repair (GO:0000726)3.68945479
35centriole replication (GO:0007099)3.68656032
36nuclear envelope disassembly (GO:0051081)3.65215434
37membrane disassembly (GO:0030397)3.65215434
38regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.62003071
39regulation of mitotic spindle checkpoint (GO:1903504)3.62003071
40positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.58444133
41positive regulation of mitotic sister chromatid separation (GO:1901970)3.58444133
42positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.58444133
43telomere maintenance via recombination (GO:0000722)3.56659649
44chaperone-mediated protein transport (GO:0072321)3.54884750
45DNA replication-dependent nucleosome organization (GO:0034723)3.54643304
46DNA replication-dependent nucleosome assembly (GO:0006335)3.54643304
47rRNA processing (GO:0006364)3.53431602
48ribosomal large subunit biogenesis (GO:0042273)3.52046735
49rRNA modification (GO:0000154)3.51724913
50IMP metabolic process (GO:0046040)3.49778625
51ribosomal small subunit assembly (GO:0000028)3.49644027
52proteasome assembly (GO:0043248)3.49029055
53regulation of spindle organization (GO:0090224)3.45223352
54replication fork processing (GO:0031297)3.45184027
55ATP synthesis coupled proton transport (GO:0015986)3.44581648
56energy coupled proton transport, down electrochemical gradient (GO:0015985)3.44581648
57kinetochore organization (GO:0051383)3.44099365
58protein neddylation (GO:0045116)3.43620621
59rRNA metabolic process (GO:0016072)3.43376580
60protein localization to chromosome, centromeric region (GO:0071459)3.42092813
61mitotic recombination (GO:0006312)3.41660483
62DNA replication-independent nucleosome assembly (GO:0006336)3.41236855
63DNA replication-independent nucleosome organization (GO:0034724)3.41236855
64regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.39595465
65pseudouridine synthesis (GO:0001522)3.38896620
66mitochondrial respiratory chain complex assembly (GO:0033108)3.38878902
67protein complex biogenesis (GO:0070271)3.38612258
68DNA ligation (GO:0006266)3.37103622
69folic acid-containing compound biosynthetic process (GO:0009396)3.35759753
70somatic hypermutation of immunoglobulin genes (GO:0016446)3.34195668
71somatic diversification of immune receptors via somatic mutation (GO:0002566)3.34195668
72mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.33577200
73DNA catabolic process, exonucleolytic (GO:0000738)3.32861352
74telomere maintenance via telomere lengthening (GO:0010833)3.32053332
75maturation of 5.8S rRNA (GO:0000460)3.31840343
76histone mRNA metabolic process (GO:0008334)3.31269399
77spliceosomal snRNP assembly (GO:0000387)3.31232010
78somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.30182279
79somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.30182279
80isotype switching (GO:0045190)3.30182279
81pore complex assembly (GO:0046931)3.29352653
82anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.28071300
83establishment of chromosome localization (GO:0051303)3.27791768
84double-strand break repair via homologous recombination (GO:0000724)3.27200251
85recombinational repair (GO:0000725)3.27021576
86kinetochore assembly (GO:0051382)3.25447688
87mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.24730219
88mitochondrial respiratory chain complex I assembly (GO:0032981)3.24730219
89NADH dehydrogenase complex assembly (GO:0010257)3.24730219
90cytochrome complex assembly (GO:0017004)3.24416151
91transcription elongation from RNA polymerase I promoter (GO:0006362)3.23809250
92negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.21905112
93regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.21312297
94positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.19878565
95histone exchange (GO:0043486)3.19689910
96transcription-coupled nucleotide-excision repair (GO:0006283)3.16588547
97regulation of DNA endoreduplication (GO:0032875)3.15693065
98ribosomal small subunit biogenesis (GO:0042274)3.15663372
99nucleotide-excision repair, DNA gap filling (GO:0006297)3.13369468
100tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.12026159
101RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.12026159
102translational initiation (GO:0006413)3.08840577
103transcription from RNA polymerase I promoter (GO:0006360)3.08488151
104regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.08420751
105positive regulation of chromosome segregation (GO:0051984)3.07655310
106termination of RNA polymerase I transcription (GO:0006363)3.07600581
107mitotic sister chromatid segregation (GO:0000070)3.07303213
1087-methylguanosine mRNA capping (GO:0006370)3.06950677
109attachment of spindle microtubules to kinetochore (GO:0008608)3.04485836
110termination of RNA polymerase III transcription (GO:0006386)3.04134807
111transcription elongation from RNA polymerase III promoter (GO:0006385)3.04134807
112cell cycle G1/S phase transition (GO:0044843)3.04033536
113G1/S transition of mitotic cell cycle (GO:0000082)3.04033536
114DNA damage response, detection of DNA damage (GO:0042769)3.02751658
115meiotic chromosome segregation (GO:0045132)3.01909058
116rRNA methylation (GO:0031167)3.01651014
117response to X-ray (GO:0010165)3.00947834
118spindle checkpoint (GO:0031577)3.00289111
1197-methylguanosine RNA capping (GO:0009452)2.99899090
120RNA capping (GO:0036260)2.99899090
121regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.97730163
122regulation of mitotic metaphase/anaphase transition (GO:0030071)2.97730163
123negative regulation of chromosome segregation (GO:0051985)2.97556231
124translational termination (GO:0006415)2.96945922
125protein K6-linked ubiquitination (GO:0085020)2.95917845
126regulation of mitotic spindle organization (GO:0060236)2.95709867
127organelle disassembly (GO:1903008)2.95080667
128negative regulation of sister chromatid segregation (GO:0033046)2.94288190
129negative regulation of mitotic sister chromatid separation (GO:2000816)2.94288190
130negative regulation of mitotic sister chromatid segregation (GO:0033048)2.94288190
131negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.94288190
132regulation of helicase activity (GO:0051095)2.94213949
133establishment of integrated proviral latency (GO:0075713)2.93972025
134viral transcription (GO:0019083)2.93801831
135postreplication repair (GO:0006301)2.93710615
136negative regulation of ligase activity (GO:0051352)2.93226825
137negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.93226825
138protein deneddylation (GO:0000338)2.93126821
139mitotic chromosome condensation (GO:0007076)2.92471897
140cullin deneddylation (GO:0010388)2.92423203
141spindle assembly checkpoint (GO:0071173)2.91193618
142DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.90833985
143mitotic spindle assembly checkpoint (GO:0007094)2.90819879
144intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.89802661
145signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.89802661
146mitotic spindle checkpoint (GO:0071174)2.89677985
147tRNA processing (GO:0008033)2.89621296
148RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.89408640
149mitochondrial RNA metabolic process (GO:0000959)2.89371647
150intracellular protein transmembrane import (GO:0044743)2.89037588
151respiratory electron transport chain (GO:0022904)2.88973341
152water-soluble vitamin biosynthetic process (GO:0042364)2.88847448
153DNA geometric change (GO:0032392)2.88606861
154signal transduction involved in DNA integrity checkpoint (GO:0072401)2.88216222
155regulation of sister chromatid segregation (GO:0033045)2.87235450
156regulation of mitotic sister chromatid separation (GO:0010965)2.87235450
157regulation of mitotic sister chromatid segregation (GO:0033047)2.87235450
158electron transport chain (GO:0022900)2.87121747
159regulation of centriole replication (GO:0046599)2.86300523
160platelet dense granule organization (GO:0060155)2.84916254
161regulation of cellular amino acid metabolic process (GO:0006521)2.84319693
162signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.81151770

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.47935629
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.42774221
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.53504984
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.43291587
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.42789923
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.35384421
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.17788470
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.09612430
9* GABP_17652178_ChIP-ChIP_JURKAT_Human3.08203796
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.99425827
11* ETS1_20019798_ChIP-Seq_JURKAT_Human2.93185431
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.91408915
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.90868468
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.84542884
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.70700087
16VDR_22108803_ChIP-Seq_LS180_Human2.69597649
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.45035486
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.44321869
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.44238189
20VDR_23849224_ChIP-Seq_CD4+_Human2.36422298
21XRN2_22483619_ChIP-Seq_HELA_Human2.25157208
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24699093
23ZNF274_21170338_ChIP-Seq_K562_Hela2.23602107
24POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14030439
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.09214198
26EWS_26573619_Chip-Seq_HEK293_Human2.06968189
27* FOXP3_21729870_ChIP-Seq_TREG_Human2.05920628
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.05725513
29FUS_26573619_Chip-Seq_HEK293_Human2.05089117
30* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.02461168
31DCP1A_22483619_ChIP-Seq_HELA_Human1.98508234
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.97542521
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.97527898
34AR_21909140_ChIP-Seq_LNCAP_Human1.95936811
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.94706198
36* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92174185
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91990694
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91720845
39GABP_19822575_ChIP-Seq_HepG2_Human1.89861844
40* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.89338964
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.89229731
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.85475439
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.82854262
44* ELK1_19687146_ChIP-ChIP_HELA_Human1.82490606
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.82440478
46* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79481599
47TTF2_22483619_ChIP-Seq_HELA_Human1.78769943
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77592050
49* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.69893825
50TAF15_26573619_Chip-Seq_HEK293_Human1.69431939
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.68237228
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64742526
53CIITA_25753668_ChIP-Seq_RAJI_Human1.60831976
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59903150
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56310485
56P300_19829295_ChIP-Seq_ESCs_Human1.55099590
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.53477707
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52963604
59KDM5A_27292631_Chip-Seq_BREAST_Human1.49802320
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49011078
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48652152
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45822038
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.45543160
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44729741
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.43442791
66IGF1R_20145208_ChIP-Seq_DFB_Human1.38515186
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37573181
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36330261
69SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.34655606
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30733038
71MYC_22102868_ChIP-Seq_BL_Human1.28676761
72STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27996174
73POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27688708
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26127183
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25932937
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25568053
77TFEB_21752829_ChIP-Seq_HELA_Human1.24238358
78* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23859089
79SALL1_21062744_ChIP-ChIP_HESCs_Human1.23385398
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22966869
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22759750
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.20774976
83* NOTCH1_21737748_ChIP-Seq_TLL_Human1.20751411
84IRF1_19129219_ChIP-ChIP_H3396_Human1.19855108
85* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19297737
86GATA1_22025678_ChIP-Seq_K562_Human1.19094696
87ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18562903
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17044317
89PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16651119
90SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15977545
91TP63_19390658_ChIP-ChIP_HaCaT_Human1.15779389
92GBX2_23144817_ChIP-Seq_PC3_Human1.15389082
93KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14509741
94CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13620251
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.13502734
96* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13274472
97ER_23166858_ChIP-Seq_MCF-7_Human1.12867624
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12732185
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12611794
100CBP_20019798_ChIP-Seq_JUKART_Human1.12611794
101* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10500605
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09884254
103CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09602585
104SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09177551
105E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05659060
106EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05165607
107PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03206037
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02550298
109RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01832900
110* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00218255
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99985369
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99818390
113* TP53_22573176_ChIP-Seq_HFKS_Human0.99747115
114SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99625018
115NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.98846811
116NANOG_16153702_ChIP-ChIP_HESCs_Human0.98733330
117TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97916953
118CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97737064
119MYC_18940864_ChIP-ChIP_HL60_Human0.97369637
120NANOG_19829295_ChIP-Seq_ESCs_Human0.96684001
121SOX2_19829295_ChIP-Seq_ESCs_Human0.96684001
122GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96599545
123* ELK1_22589737_ChIP-Seq_MCF10A_Human0.96254252
124HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95126796
125KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94400327
126CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92241616
127KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92141377
128* SPI1_23547873_ChIP-Seq_NB4_Human0.92094879
129KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91725690
130* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91628732
131CRX_20693478_ChIP-Seq_RETINA_Mouse0.91601376
132NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91483457
133OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91004722
134CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90728556
135KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.89518852
136KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.89518852
137KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.89518852
138BCAT_22108803_ChIP-Seq_LS180_Human0.87593238
139TCF4_22108803_ChIP-Seq_LS180_Human0.87586700
140HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87555354
141GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87230841
142CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87109767
143NANOG_21062744_ChIP-ChIP_HESCs_Human0.86539470
144NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.84429022
145DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82808277
146FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.82728074
147CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.81483716
148CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79950034

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.71596384
2MP0010094_abnormal_chromosome_stability4.97098220
3MP0003111_abnormal_nucleus_morphology4.52547168
4MP0004957_abnormal_blastocyst_morpholog4.47088027
5MP0008057_abnormal_DNA_replication4.46485608
6MP0003077_abnormal_cell_cycle4.21234252
7MP0008058_abnormal_DNA_repair4.00588802
8MP0008007_abnormal_cellular_replicative3.08482522
9MP0002102_abnormal_ear_morphology2.93086496
10MP0008932_abnormal_embryonic_tissue2.81178324
11MP0003123_paternal_imprinting2.54405793
12MP0006072_abnormal_retinal_apoptosis2.53268266
13MP0000372_irregular_coat_pigmentation2.51029248
14MP0001730_embryonic_growth_arrest2.49189580
15MP0002396_abnormal_hematopoietic_system2.39766329
16MP0003786_premature_aging2.34893592
17MP0000350_abnormal_cell_proliferation2.32244281
18MP0008877_abnormal_DNA_methylation2.28428604
19MP0010352_gastrointestinal_tract_polyps2.24213682
20MP0010307_abnormal_tumor_latency2.10602401
21MP0003718_maternal_effect2.06262916
22MP0002938_white_spotting2.00260564
23MP0003195_calcinosis1.97898489
24MP0001672_abnormal_embryogenesis/_devel1.84542433
25MP0005380_embryogenesis_phenotype1.84542433
26MP0005253_abnormal_eye_physiology1.80445269
27MP0001697_abnormal_embryo_size1.77991679
28MP0009333_abnormal_splenocyte_physiolog1.74251352
29MP0003806_abnormal_nucleotide_metabolis1.69671833
30MP0003984_embryonic_growth_retardation1.66627375
31MP0002080_prenatal_lethality1.63249444
32MP0002088_abnormal_embryonic_growth/wei1.62575185
33MP0001529_abnormal_vocalization1.59700947
34MP0005084_abnormal_gallbladder_morpholo1.58482084
35MP0002837_dystrophic_cardiac_calcinosis1.56572919
36MP0003763_abnormal_thymus_physiology1.56234569
37MP0005075_abnormal_melanosome_morpholog1.56079715
38MP0008789_abnormal_olfactory_epithelium1.55859727
39MP0002085_abnormal_embryonic_tissue1.53412305
40MP0002019_abnormal_tumor_incidence1.53180917
41MP0002751_abnormal_autonomic_nervous1.51298706
42MP0000313_abnormal_cell_death1.50938942
43MP0000490_abnormal_crypts_of1.50460958
44MP0002086_abnormal_extraembryonic_tissu1.40433299
45MP0002084_abnormal_developmental_patter1.38971722
46MP0002234_abnormal_pharynx_morphology1.38183771
47MP0004147_increased_porphyrin_level1.34368368
48MP0004808_abnormal_hematopoietic_stem1.34021005
49MP0000566_synostosis1.30651115
50MP0004197_abnormal_fetal_growth/weight/1.30217742
51MP0002210_abnormal_sex_determination1.30022071
52MP0008995_early_reproductive_senescence1.29635916
53MP0003121_genomic_imprinting1.29598903
54MP0003567_abnormal_fetal_cardiomyocyte1.28935263
55MP0005551_abnormal_eye_electrophysiolog1.21950105
56MP0002090_abnormal_vision1.20055490
57MP0001764_abnormal_homeostasis1.18246954
58MP0000703_abnormal_thymus_morphology1.16768819
59MP0002736_abnormal_nociception_after1.16586291
60MP0001145_abnormal_male_reproductive1.15473639
61MP0002638_abnormal_pupillary_reflex1.13926805
62MP0003890_abnormal_embryonic-extraembry1.13498003
63MP0002398_abnormal_bone_marrow1.13148440
64MP0003221_abnormal_cardiomyocyte_apopto1.11302766
65MP0002722_abnormal_immune_system1.08793404
66MP0000689_abnormal_spleen_morphology1.07911307
67MP0003787_abnormal_imprinting1.07637725
68MP0000569_abnormal_digit_pigmentation1.06950482
69MP0001293_anophthalmia1.06374546
70MP0003941_abnormal_skin_development1.03745427
71MP0000647_abnormal_sebaceous_gland1.03694871
72MP0001929_abnormal_gametogenesis1.01929847
73MP0001485_abnormal_pinna_reflex1.00908733
74MP0005397_hematopoietic_system_phenotyp1.00753819
75MP0001545_abnormal_hematopoietic_system1.00753819
76MP0000653_abnormal_sex_gland1.00746428
77MP0004142_abnormal_muscle_tone1.00662754
78MP0001286_abnormal_eye_development1.00265059
79MP0003186_abnormal_redox_activity0.96725899
80MP0001984_abnormal_olfaction0.96297640
81MP0005384_cellular_phenotype0.96060389
82MP0001919_abnormal_reproductive_system0.95384785
83MP0008872_abnormal_physiological_respon0.95181310
84MP0000358_abnormal_cell_content/0.94766032
85MP0000427_abnormal_hair_cycle0.94742122
86MP0005379_endocrine/exocrine_gland_phen0.94493842
87MP0005621_abnormal_cell_physiology0.93407986
88MP0003136_yellow_coat_color0.93281215
89MP0003646_muscle_fatigue0.92908648
90MP0002254_reproductive_system_inflammat0.92698108
91MP0002233_abnormal_nose_morphology0.92382464
92MP0005671_abnormal_response_to0.92022997
93MP0005391_vision/eye_phenotype0.92006463
94MP0010030_abnormal_orbit_morphology0.91699893
95MP0002653_abnormal_ependyma_morphology0.91158908
96MP0000383_abnormal_hair_follicle0.90725263
97MP0001119_abnormal_female_reproductive0.87853094
98MP0002429_abnormal_blood_cell0.86711700
99MP0001188_hyperpigmentation0.86109053
100MP0009046_muscle_twitch0.85351076
101MP0000516_abnormal_urinary_system0.84749298
102MP0005367_renal/urinary_system_phenotyp0.84749298
103MP0005076_abnormal_cell_differentiation0.84697121
104MP0004215_abnormal_myocardial_fiber0.84642305
105MP0002095_abnormal_skin_pigmentation0.83974209
106MP0003880_abnormal_central_pattern0.82794612
107MP0000858_altered_metastatic_potential0.78609870
108MP0005499_abnormal_olfactory_system0.77773210
109MP0005394_taste/olfaction_phenotype0.77773210
110MP0000716_abnormal_immune_system0.77716555
111MP0006276_abnormal_autonomic_nervous0.76960464
112MP0003119_abnormal_digestive_system0.76374167
113MP0000750_abnormal_muscle_regeneration0.76324758
114MP0002111_abnormal_tail_morphology0.75876492
115MP0002277_abnormal_respiratory_mucosa0.75280776
116MP0002160_abnormal_reproductive_system0.74813581
117MP0005408_hypopigmentation0.74751622
118MP0006292_abnormal_olfactory_placode0.73551663
119MP0004133_heterotaxia0.73431141
120MP0003950_abnormal_plasma_membrane0.73359534
121MP0003011_delayed_dark_adaptation0.73085847
122MP0000631_abnormal_neuroendocrine_gland0.73030978
123MP0005023_abnormal_wound_healing0.71732045
124MP0002132_abnormal_respiratory_system0.71584660
125MP0006036_abnormal_mitochondrial_physio0.70604931
126MP0005332_abnormal_amino_acid0.70457299
127MP0006035_abnormal_mitochondrial_morpho0.70254116
128MP0003566_abnormal_cell_adhesion0.69941831
129MP0001324_abnormal_eye_pigmentation0.69904935
130MP0001835_abnormal_antigen_presentation0.68991302
131MP0003315_abnormal_perineum_morphology0.68818813
132MP0001800_abnormal_humoral_immune0.68618051
133MP0005174_abnormal_tail_pigmentation0.68395233
134MP0003937_abnormal_limbs/digits/tail_de0.68227166
135MP0001915_intracranial_hemorrhage0.68207041
136MP0005646_abnormal_pituitary_gland0.67146085
137MP0002405_respiratory_system_inflammati0.66235464
138MP0001853_heart_inflammation0.65563104
139MP0005389_reproductive_system_phenotype0.64362030
140MP0008260_abnormal_autophagy0.63207708
141MP0009053_abnormal_anal_canal0.62963984
142MP0009672_abnormal_birth_weight0.62346843
143MP0004264_abnormal_extraembryonic_tissu0.62013817
144MP0002420_abnormal_adaptive_immunity0.60654035
145MP0003448_altered_tumor_morphology0.60466599
146MP0002452_abnormal_antigen_presenting0.59976112
147MP0001819_abnormal_immune_cell0.59831902
148MP0009697_abnormal_copulation0.59375543
149MP0002163_abnormal_gland_morphology0.58504606
150MP0005266_abnormal_metabolism0.58058262
151MP0002723_abnormal_immune_serum0.56546997
152MP0005395_other_phenotype0.55139669
153MP0002127_abnormal_cardiovascular_syste0.52694856
154MP0000477_abnormal_intestine_morphology0.52335317
155MP0001243_abnormal_dermal_layer0.51542695
156MP0001873_stomach_inflammation0.48555839
157MP0002006_tumorigenesis0.48472755

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.07724703
2Breast hypoplasia (HP:0003187)4.18013971
3Acute necrotizing encephalopathy (HP:0006965)3.99614040
4Cerebral hypomyelination (HP:0006808)3.70598187
5Ependymoma (HP:0002888)3.59109491
6Acute encephalopathy (HP:0006846)3.56798184
7Increased hepatocellular lipid droplets (HP:0006565)3.54788632
8Carpal bone hypoplasia (HP:0001498)3.52072620
9Progressive macrocephaly (HP:0004481)3.50787719
10Reticulocytopenia (HP:0001896)3.49748407
11Chromsome breakage (HP:0040012)3.48902331
12Abnormal mitochondria in muscle tissue (HP:0008316)3.47180157
13Abnormality of cells of the erythroid lineage (HP:0012130)3.44926129
14Mitochondrial inheritance (HP:0001427)3.44010123
15Increased CSF lactate (HP:0002490)3.38899209
16Agnosia (HP:0010524)3.36318091
17Lipid accumulation in hepatocytes (HP:0006561)3.34774055
18Patellar aplasia (HP:0006443)3.31926098
19Rough bone trabeculation (HP:0100670)3.28731115
20Oral leukoplakia (HP:0002745)3.24787602
21Chromosomal breakage induced by crosslinking agents (HP:0003221)3.24244268
22Abnormality of the labia minora (HP:0012880)3.22830470
23Medulloblastoma (HP:0002885)3.20037489
24Abnormal number of erythroid precursors (HP:0012131)3.17086139
25Colon cancer (HP:0003003)3.11701344
26Aplasia/Hypoplasia of the patella (HP:0006498)3.08318602
27Selective tooth agenesis (HP:0001592)3.04606882
28Stenosis of the external auditory canal (HP:0000402)3.04101536
29Pancreatic cysts (HP:0001737)2.99041094
30Abnormality of chromosome stability (HP:0003220)2.96871541
31Rhabdomyosarcoma (HP:0002859)2.96046203
32Abnormality of the preputium (HP:0100587)2.92117427
33Abnormality of midbrain morphology (HP:0002418)2.91964432
34Molar tooth sign on MRI (HP:0002419)2.91964432
35Meckel diverticulum (HP:0002245)2.91247232
36Degeneration of anterior horn cells (HP:0002398)2.85102284
37Abnormality of the anterior horn cell (HP:0006802)2.85102284
38Hepatocellular necrosis (HP:0001404)2.82342427
39Abnormality of the ileum (HP:0001549)2.81910702
40Pancreatic fibrosis (HP:0100732)2.78403256
41Premature graying of hair (HP:0002216)2.77412612
42Impulsivity (HP:0100710)2.75366816
43Aplastic anemia (HP:0001915)2.72988357
44Cerebral edema (HP:0002181)2.70312488
45True hermaphroditism (HP:0010459)2.65888553
46Myelodysplasia (HP:0002863)2.62254219
47Absent thumb (HP:0009777)2.61916691
48Renal Fanconi syndrome (HP:0001994)2.60622682
49Absent radius (HP:0003974)2.59821252
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.59465568
513-Methylglutaconic aciduria (HP:0003535)2.59283341
52Hepatic necrosis (HP:0002605)2.58685356
53Bone marrow hypocellularity (HP:0005528)2.57900298
54Glossoptosis (HP:0000162)2.55778161
55Irregular epiphyses (HP:0010582)2.54740324
56Neoplasm of the pancreas (HP:0002894)2.52349945
57Supernumerary spleens (HP:0009799)2.48005713
58Medial flaring of the eyebrow (HP:0010747)2.45874651
59Astrocytoma (HP:0009592)2.44703071
60Abnormality of the astrocytes (HP:0100707)2.44703071
61Increased serum lactate (HP:0002151)2.44312663
62Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.43470856
63Methylmalonic acidemia (HP:0002912)2.40258039
64Premature ovarian failure (HP:0008209)2.39796254
65Basal cell carcinoma (HP:0002671)2.38959789
66Lactic acidosis (HP:0003128)2.38269305
67Duodenal stenosis (HP:0100867)2.37961668
68Small intestinal stenosis (HP:0012848)2.37961668
69Absent forearm bone (HP:0003953)2.36019497
70Aplasia involving forearm bones (HP:0009822)2.36019497
71Sloping forehead (HP:0000340)2.33243830
72Secondary amenorrhea (HP:0000869)2.31334330
73Hypoplasia of the capital femoral epiphysis (HP:0003090)2.31272599
74Abnormal trabecular bone morphology (HP:0100671)2.29200840
75Cellular immunodeficiency (HP:0005374)2.27765070
76Glioma (HP:0009733)2.27696339
77Macrocytic anemia (HP:0001972)2.27484365
78Abnormal lung lobation (HP:0002101)2.26876266
79Neoplasm of striated muscle (HP:0009728)2.26832979
80Congenital, generalized hypertrichosis (HP:0004540)2.25881198
81Trismus (HP:0000211)2.24778744
82Pallor (HP:0000980)2.21988270
83Type I transferrin isoform profile (HP:0003642)2.21381728
8411 pairs of ribs (HP:0000878)2.20802524
85Abnormality of methionine metabolism (HP:0010901)2.20623649
86Amaurosis fugax (HP:0100576)2.20598760
87CNS hypomyelination (HP:0003429)2.20230597
88Exertional dyspnea (HP:0002875)2.18820423
89Nephronophthisis (HP:0000090)2.17393347
90Horseshoe kidney (HP:0000085)2.16276692
91Respiratory failure (HP:0002878)2.15477178
92Lymphoma (HP:0002665)2.13686198
93Squamous cell carcinoma (HP:0002860)2.13439076
94Hyperglycinemia (HP:0002154)2.12589961
95Duplicated collecting system (HP:0000081)2.11524113
96Clubbing of toes (HP:0100760)2.11093564
97Microretrognathia (HP:0000308)2.11023965
98Renal cortical cysts (HP:0000803)2.09673300
99Ectopic kidney (HP:0000086)2.09454628
100Abnormality of glycolysis (HP:0004366)2.08786455
101Increased serum pyruvate (HP:0003542)2.08786455
102Entropion (HP:0000621)2.07901801
103Hypoplastic pelvis (HP:0008839)2.06712305
104Abnormality of the renal collecting system (HP:0004742)2.06196855
105Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05777418
106Abnormality of alanine metabolism (HP:0010916)2.05777418
107Hyperalaninemia (HP:0003348)2.05777418
108Abnormality of the duodenum (HP:0002246)2.04203733
109Atresia of the external auditory canal (HP:0000413)2.03438178
110Abnormality of aspartate family amino acid metabolism (HP:0010899)2.02924540
111Thrombocytosis (HP:0001894)2.02413216
112Deviation of the thumb (HP:0009603)2.01565343
113Intestinal atresia (HP:0011100)2.01384643
114Aplasia/Hypoplasia of the sternum (HP:0006714)2.01093757
115Congenital primary aphakia (HP:0007707)2.00577607
116Aplasia/Hypoplasia of the tibia (HP:0005772)2.00357006
117Abolished electroretinogram (ERG) (HP:0000550)1.99749293
118Proximal placement of thumb (HP:0009623)1.99465867
119Abnormal number of incisors (HP:0011064)1.98778583
120Slender long bone (HP:0003100)1.98371524
121Aplasia/Hypoplasia of the sacrum (HP:0008517)1.98105218
122Abnormal protein glycosylation (HP:0012346)1.97893523
123Abnormal glycosylation (HP:0012345)1.97893523
124Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.97893523
125Abnormal protein N-linked glycosylation (HP:0012347)1.97893523
126Rectovaginal fistula (HP:0000143)1.97846680
127Rectal fistula (HP:0100590)1.97846680
128Ureteral duplication (HP:0000073)1.97606879
129Cafe-au-lait spot (HP:0000957)1.97316406
130Short tibia (HP:0005736)1.96775144
131Tracheoesophageal fistula (HP:0002575)1.95965560
132IgM deficiency (HP:0002850)1.95801325
133Abnormality of serum amino acid levels (HP:0003112)1.95252039
134Pancreatic islet-cell hyperplasia (HP:0004510)1.95172592
135Hypothermia (HP:0002045)1.94846647
136Increased intramyocellular lipid droplets (HP:0012240)1.94634919
137Aplasia/Hypoplasia of the tongue (HP:0010295)1.94431958
138Abnormality of the renal cortex (HP:0011035)1.94187961
139Methylmalonic aciduria (HP:0012120)1.93526250
140Absent epiphyses (HP:0010577)1.92741483
141Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.92741483
142Biliary tract neoplasm (HP:0100574)1.92436756
143Neoplasm of the oral cavity (HP:0100649)1.92208831
144Optic disc pallor (HP:0000543)1.90946797
145Facial hemangioma (HP:0000329)1.88772620
146Triphalangeal thumb (HP:0001199)1.87545782
147Exercise intolerance (HP:0003546)1.87368042
148Abnormality of the renal medulla (HP:0100957)1.86788671
149Decreased activity of mitochondrial respiratory chain (HP:0008972)1.86301883
150Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.86301883
151Poikiloderma (HP:0001029)1.86081497
152Median cleft lip (HP:0000161)1.85479544
153Gait imbalance (HP:0002141)1.84791434
154Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.83900299
155Multiple enchondromatosis (HP:0005701)1.82870665
156Nephrogenic diabetes insipidus (HP:0009806)1.82684187
157Large for gestational age (HP:0001520)1.82077746
158Abnormality of DNA repair (HP:0003254)1.81976281
159Cleft eyelid (HP:0000625)1.81457382
160Leukodystrophy (HP:0002415)1.80261590
161Abnormality of renal resorption (HP:0011038)1.79829540
162Nephroblastoma (Wilms tumor) (HP:0002667)1.78671320
163Volvulus (HP:0002580)1.78550457
164Abnormality of the umbilical cord (HP:0010881)1.77601122
165Prominent nose (HP:0000448)1.77046546
166Abnormality of the pons (HP:0007361)1.75601079
167Sclerocornea (HP:0000647)1.74062814
168Genital tract atresia (HP:0001827)1.72661417
169Abnormal biliary tract physiology (HP:0012439)1.72333901
170Bile duct proliferation (HP:0001408)1.72333901
171Embryonal renal neoplasm (HP:0011794)1.72034072
172Chronic hepatic failure (HP:0100626)1.71197378
173Lethargy (HP:0001254)1.70916064
174CNS demyelination (HP:0007305)1.69090412

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.59744361
2WEE14.13194509
3CDC73.65258886
4EIF2AK13.61956026
5MAP4K23.19265209
6TSSK63.17181627
7NUAK12.54265139
8FRK2.53677460
9SRPK12.53088451
10BMPR1B2.36559388
11TTK2.35376250
12EIF2AK32.25991839
13STK162.23737208
14NEK22.19689606
15VRK22.12264303
16PLK42.11497319
17ACVR1B2.08513503
18PLK12.04965308
19NEK12.03963055
20BRSK22.00429670
21WNK31.96777603
22TRIM281.93476072
23NME21.89986457
24PLK31.80389512
25MKNK11.79744123
26PASK1.70073521
27EPHA21.69050942
28AURKB1.68107906
29ATR1.66250676
30PIM21.58306470
31TESK21.57234517
32TNIK1.53106779
33CDK71.51953557
34CHEK21.50121931
35MKNK21.45484512
36TLK11.44369633
37CCNB11.41363095
38CDK121.39931487
39RPS6KB21.39759226
40VRK11.33696886
41ERBB31.33483745
42STK101.31389195
43CHEK11.30588627
44MST41.30263879
45MAP4K11.26459395
46TAF11.19541843
47DYRK31.15143957
48INSRR1.15106791
49MAP3K81.14770209
50CDK41.11919300
51AURKA1.10828171
52PIM11.08201898
53PLK21.08115884
54MAP3K41.07507661
55RPS6KA41.06971420
56OXSR11.05975162
57PNCK1.04900172
58STK391.03425203
59GRK11.00409439
60TGFBR10.97944136
61MAP3K120.95326743
62CSNK1G10.95118872
63BRSK10.94993549
64ADRBK20.94418370
65TXK0.94206511
66EIF2AK20.92101222
67STK40.91907853
68ATM0.90205172
69BRAF0.90076070
70MELK0.86337730
71CDK20.85682204
72CDK80.84888331
73SCYL20.82380340
74ZAK0.81229126
75BMPR20.77965401
76BCR0.77893723
77ALK0.77605782
78PBK0.77025116
79PDK20.76987715
80FLT30.75677965
81CSNK1G30.74583680
82CSNK2A20.74381340
83STK38L0.72664625
84CSNK1G20.71792885
85PAK40.71411890
86PIK3CG0.70096368
87STK30.69328006
88CSNK2A10.66398856
89PAK10.65988343
90CSNK1A1L0.65920478
91MAPKAPK50.65002767
92BCKDK0.64328271
93CDK10.62780846
94EEF2K0.61840438
95ERBB40.60439690
96ARAF0.55395445
97MUSK0.55013158
98RPS6KA50.54102183
99CDK30.54084225
100CDK60.54041712
101AKT30.53905151
102NLK0.53728827
103YES10.53150715
104KIT0.51400934
105RAF10.50864998
106MARK30.49834482
107MAP2K70.48999120
108ABL20.48382295
109WNK40.48025016
110BRD40.47838302
111PINK10.47335661
112LATS10.45110030
113PDK40.45019511
114PDK30.45019511
115TAOK30.44131885
116IKBKB0.44076484
117IRAK30.43661653
118TEC0.42233404
119NME10.41582770
120MAP3K110.41456570
121OBSCN0.41370602
122PAK30.40834441
123PRKCI0.40287017
124CASK0.40135942
125PRKCE0.39526681
126JAK30.37846009
127CSNK1E0.37065075
128TESK10.35593219
129DYRK1A0.33803697
130LIMK10.33224364
131CSNK1A10.33012931
132ZAP700.32137615
133MAP3K50.31068304
134MAPK130.30879915
135NEK90.29680512
136PRKDC0.29277163
137TAOK20.29136490
138LRRK20.29048430
139AKT20.27270920
140PRKCG0.26055313
141GRK70.25986250
142MTOR0.25976256
143FGFR10.25778022
144CDK190.25682646
145MAP3K30.24617678
146DYRK20.23326590

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.48807457
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.26655211
3Mismatch repair_Homo sapiens_hsa034304.18822909
4Proteasome_Homo sapiens_hsa030503.67800827
5RNA polymerase_Homo sapiens_hsa030203.65113514
6RNA transport_Homo sapiens_hsa030133.32771082
7Spliceosome_Homo sapiens_hsa030403.19140411
8Ribosome_Homo sapiens_hsa030103.07936861
9Nucleotide excision repair_Homo sapiens_hsa034202.87273065
10Homologous recombination_Homo sapiens_hsa034402.82634269
11Base excision repair_Homo sapiens_hsa034102.80488386
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.63714495
13Cell cycle_Homo sapiens_hsa041102.62372382
14One carbon pool by folate_Homo sapiens_hsa006702.43931752
15Non-homologous end-joining_Homo sapiens_hsa034502.34172845
16Pyrimidine metabolism_Homo sapiens_hsa002402.32008358
17Fanconi anemia pathway_Homo sapiens_hsa034602.18609560
18Basal transcription factors_Homo sapiens_hsa030222.17214930
19RNA degradation_Homo sapiens_hsa030182.06189834
20Propanoate metabolism_Homo sapiens_hsa006401.86476913
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76727296
22mRNA surveillance pathway_Homo sapiens_hsa030151.72777353
23p53 signaling pathway_Homo sapiens_hsa041151.59962582
24Alzheimers disease_Homo sapiens_hsa050101.47356659
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42075253
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38513509
27Epstein-Barr virus infection_Homo sapiens_hsa051691.38095530
28Vitamin B6 metabolism_Homo sapiens_hsa007501.35497653
29Purine metabolism_Homo sapiens_hsa002301.33466314
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.27155899
31Butanoate metabolism_Homo sapiens_hsa006501.16823224
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.16076889
33Fatty acid elongation_Homo sapiens_hsa000621.09768482
34Steroid biosynthesis_Homo sapiens_hsa001001.06724878
35Antigen processing and presentation_Homo sapiens_hsa046121.06286402
36Systemic lupus erythematosus_Homo sapiens_hsa053221.01767795
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01455518
38Pyruvate metabolism_Homo sapiens_hsa006200.96660417
39Viral carcinogenesis_Homo sapiens_hsa052030.94495893
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93206367
41Herpes simplex infection_Homo sapiens_hsa051680.92359836
42Folate biosynthesis_Homo sapiens_hsa007900.90529579
43Peroxisome_Homo sapiens_hsa041460.88462576
44SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87976950
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.86237397
46Phototransduction_Homo sapiens_hsa047440.86222247
47Tryptophan metabolism_Homo sapiens_hsa003800.83480300
48Oocyte meiosis_Homo sapiens_hsa041140.82728395
49Nitrogen metabolism_Homo sapiens_hsa009100.81211726
50Cardiac muscle contraction_Homo sapiens_hsa042600.79038074
51Primary immunodeficiency_Homo sapiens_hsa053400.78218864
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.73136438
53beta-Alanine metabolism_Homo sapiens_hsa004100.73106989
54Sulfur metabolism_Homo sapiens_hsa009200.73089392
55Legionellosis_Homo sapiens_hsa051340.72405488
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71022992
57Biosynthesis of amino acids_Homo sapiens_hsa012300.69784043
58Asthma_Homo sapiens_hsa053100.67399039
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65703949
60Protein export_Homo sapiens_hsa030600.65620494
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62375495
62HTLV-I infection_Homo sapiens_hsa051660.62072012
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62028954
64Collecting duct acid secretion_Homo sapiens_hsa049660.59859563
65Selenocompound metabolism_Homo sapiens_hsa004500.56743542
66Pentose phosphate pathway_Homo sapiens_hsa000300.56531016
67Apoptosis_Homo sapiens_hsa042100.56309907
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.55498843
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.55317475
70Thyroid cancer_Homo sapiens_hsa052160.54603318
71Allograft rejection_Homo sapiens_hsa053300.54217674
72MicroRNAs in cancer_Homo sapiens_hsa052060.53760007
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.53672974
74Caffeine metabolism_Homo sapiens_hsa002320.53416528
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52946226
76Measles_Homo sapiens_hsa051620.52183839
77Huntingtons disease_Homo sapiens_hsa050160.49338963
78Sulfur relay system_Homo sapiens_hsa041220.48120990
79Fructose and mannose metabolism_Homo sapiens_hsa000510.47844508
80Fatty acid degradation_Homo sapiens_hsa000710.47676967
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46672808
82Fatty acid metabolism_Homo sapiens_hsa012120.45506878
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45294289
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45047551
85Retinol metabolism_Homo sapiens_hsa008300.44863107
86Graft-versus-host disease_Homo sapiens_hsa053320.44792088
87Small cell lung cancer_Homo sapiens_hsa052220.43802052
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43466198
89Chemical carcinogenesis_Homo sapiens_hsa052040.43315009
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40131913
91Glutathione metabolism_Homo sapiens_hsa004800.39337821
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38263614
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37375705
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35908275
95TGF-beta signaling pathway_Homo sapiens_hsa043500.35508100
96Shigellosis_Homo sapiens_hsa051310.35119080
97Taste transduction_Homo sapiens_hsa047420.34494247
98Linoleic acid metabolism_Homo sapiens_hsa005910.34412467
99Hippo signaling pathway_Homo sapiens_hsa043900.33863630
100Carbon metabolism_Homo sapiens_hsa012000.33426105
101Circadian rhythm_Homo sapiens_hsa047100.33201294
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32276868
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32130386
104Rheumatoid arthritis_Homo sapiens_hsa053230.31586803
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.31370162
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31055678
107Parkinsons disease_Homo sapiens_hsa050120.31042457
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30203676
109Intestinal immune network for IgA production_Homo sapiens_hsa046720.29819141
110Hepatitis B_Homo sapiens_hsa051610.29428359
111Colorectal cancer_Homo sapiens_hsa052100.29075719
112Cyanoamino acid metabolism_Homo sapiens_hsa004600.28593683
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28339919
114Hematopoietic cell lineage_Homo sapiens_hsa046400.28063653
115Type I diabetes mellitus_Homo sapiens_hsa049400.27161121
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26895303
117Regulation of autophagy_Homo sapiens_hsa041400.26750509
118Influenza A_Homo sapiens_hsa051640.26218487
119Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25285914
120HIF-1 signaling pathway_Homo sapiens_hsa040660.24935411
121Viral myocarditis_Homo sapiens_hsa054160.24099390
122Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23978535
123Lysine degradation_Homo sapiens_hsa003100.23618420
124Olfactory transduction_Homo sapiens_hsa047400.21885930
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21783002
126Galactose metabolism_Homo sapiens_hsa000520.21074893
127Vitamin digestion and absorption_Homo sapiens_hsa049770.19137390
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.18934854
129Ether lipid metabolism_Homo sapiens_hsa005650.18675875
130Alcoholism_Homo sapiens_hsa050340.18174922
1312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.17582066
132T cell receptor signaling pathway_Homo sapiens_hsa046600.17001775
133Basal cell carcinoma_Homo sapiens_hsa052170.16857962
134Metabolic pathways_Homo sapiens_hsa011000.16294826
135Acute myeloid leukemia_Homo sapiens_hsa052210.16223444
136Pathways in cancer_Homo sapiens_hsa052000.16164581
137Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.15197591
138Autoimmune thyroid disease_Homo sapiens_hsa053200.14968368
139Oxidative phosphorylation_Homo sapiens_hsa001900.13553217
140Chronic myeloid leukemia_Homo sapiens_hsa052200.10421861
141Bladder cancer_Homo sapiens_hsa052190.09954426
142Hedgehog signaling pathway_Homo sapiens_hsa043400.09845437
143Renin-angiotensin system_Homo sapiens_hsa046140.09706645
144Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.09491045
145Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.08330593

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