SRGAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a GTPase activator, working with the GTPase CDC42 to negatively regulate neuronal migration. The encoded protein interacts with the transmembrane receptor ROBO1 to inactivate CDC42. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.72861724
2neuron cell-cell adhesion (GO:0007158)4.54276964
3layer formation in cerebral cortex (GO:0021819)4.54123791
4vocalization behavior (GO:0071625)4.41192275
5neuron recognition (GO:0008038)4.21081433
6cell migration in hindbrain (GO:0021535)4.09729496
7axonal fasciculation (GO:0007413)4.08874584
8dendritic spine morphogenesis (GO:0060997)4.05980909
9locomotory exploration behavior (GO:0035641)4.04563274
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.03722377
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.00637698
12pyrimidine nucleobase catabolic process (GO:0006208)3.99577229
13response to lipoprotein particle (GO:0055094)3.99157088
14branching involved in labyrinthine layer morphogenesis (GO:0060670)3.93132291
15regulation of short-term neuronal synaptic plasticity (GO:0048172)3.92749985
16dendrite morphogenesis (GO:0048813)3.89473356
17positive regulation of oligodendrocyte differentiation (GO:0048714)3.87535993
18somite development (GO:0061053)3.80074345
19cell proliferation in forebrain (GO:0021846)3.73853325
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.63898746
21spinal cord development (GO:0021510)3.63518544
22synaptic vesicle maturation (GO:0016188)3.62146356
23exploration behavior (GO:0035640)3.57956172
24regulation of synapse structural plasticity (GO:0051823)3.54566829
25auditory behavior (GO:0031223)3.53331997
26positive regulation of fatty acid oxidation (GO:0046321)3.53038635
27protein localization to synapse (GO:0035418)3.52504773
28regulation of glutamate receptor signaling pathway (GO:1900449)3.50809453
29negative regulation of systemic arterial blood pressure (GO:0003085)3.49390467
30postsynaptic membrane organization (GO:0001941)3.49216413
31glomerular visceral epithelial cell development (GO:0072015)3.38595543
32regulation of axon guidance (GO:1902667)3.38297041
33synaptic vesicle exocytosis (GO:0016079)3.37333396
34lateral sprouting from an epithelium (GO:0060601)3.35947671
35lymphangiogenesis (GO:0001946)3.33842999
36negative regulation of mast cell activation (GO:0033004)3.31577545
37negative regulation of synaptic transmission, GABAergic (GO:0032229)3.29332244
38central nervous system projection neuron axonogenesis (GO:0021952)3.27967400
39regulation of collateral sprouting (GO:0048670)3.25159588
40regulation of axon extension involved in axon guidance (GO:0048841)3.24082625
41mitochondrial respiratory chain complex I assembly (GO:0032981)3.23666236
42NADH dehydrogenase complex assembly (GO:0010257)3.23666236
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.23666236
44axon extension (GO:0048675)3.21875845
45ionotropic glutamate receptor signaling pathway (GO:0035235)3.20702172
46regulation of hippo signaling (GO:0035330)3.18778216
47prostate gland growth (GO:0060736)3.18496655
48sulfation (GO:0051923)3.18340627
49negative regulation of axon guidance (GO:1902668)3.18122896
50protein polyglutamylation (GO:0018095)3.17623049
51regulation of synaptic vesicle exocytosis (GO:2000300)3.17020119
52negative regulation of astrocyte differentiation (GO:0048712)3.16937937
53limb development (GO:0060173)3.13824709
54appendage development (GO:0048736)3.13824709
55negative regulation of microtubule polymerization (GO:0031115)3.10814030
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.07983616
57glomerular epithelial cell development (GO:0072310)3.07629556
58nucleobase catabolic process (GO:0046113)3.04707258
59glomerulus development (GO:0032835)3.01355257
60glutamate secretion (GO:0014047)3.01036331
61regulation of long-term neuronal synaptic plasticity (GO:0048169)2.98567365
62regulation of action potential (GO:0098900)2.97100180
63regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.94330814
64regulation of sequestering of triglyceride (GO:0010889)2.94025999
65response to auditory stimulus (GO:0010996)2.93779909
66negative regulation of telomerase activity (GO:0051974)2.93362583
67white fat cell differentiation (GO:0050872)2.93052949
68glutamate receptor signaling pathway (GO:0007215)2.92707550
69proline transport (GO:0015824)2.92088730
70neuronal action potential (GO:0019228)2.91071828
71cerebellar Purkinje cell differentiation (GO:0021702)2.90576894
72negative regulation of axon extension involved in axon guidance (GO:0048843)2.89949061
73neurotransmitter secretion (GO:0007269)2.89882737
74neuromuscular process controlling balance (GO:0050885)2.89255616
75epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.89136702
76regulation of neuronal synaptic plasticity (GO:0048168)2.88567991
77establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.88539120
78mitochondrion transport along microtubule (GO:0047497)2.88539120
79glomerular basement membrane development (GO:0032836)2.87036429
80synapse assembly (GO:0007416)2.86885659
81gamma-aminobutyric acid transport (GO:0015812)2.86576308
82kynurenine metabolic process (GO:0070189)2.86389897
83establishment of mitochondrion localization (GO:0051654)2.86258732
84synaptic vesicle docking involved in exocytosis (GO:0016081)2.85840930
85prepulse inhibition (GO:0060134)2.85387205
86synaptic transmission, glutamatergic (GO:0035249)2.85142127
87positive regulation of synapse assembly (GO:0051965)2.84737237
88peristalsis (GO:0030432)2.82844564
89indolalkylamine metabolic process (GO:0006586)2.82544602
90cerebral cortex radially oriented cell migration (GO:0021799)2.82508808
91innervation (GO:0060384)2.82314813
92retinal ganglion cell axon guidance (GO:0031290)2.81434772
93transmission of nerve impulse (GO:0019226)2.81324602
94artery development (GO:0060840)2.80328021
95positive regulation of synaptic transmission, GABAergic (GO:0032230)2.80209570
96anterior/posterior axis specification, embryo (GO:0008595)2.80125476
97regulation of dendritic spine morphogenesis (GO:0061001)2.79602288
98positive regulation of axon extension (GO:0045773)2.79310584
99purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.78036403
1003-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.78036403
101neuron projection extension (GO:1990138)2.77500929
102positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.77194112
103positive regulation of synapse maturation (GO:0090129)2.76929190
104indolalkylamine catabolic process (GO:0046218)2.74760520
105tryptophan catabolic process (GO:0006569)2.74760520
106indole-containing compound catabolic process (GO:0042436)2.74760520
107presynaptic membrane assembly (GO:0097105)2.74755447
108membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.74168925
109mechanosensory behavior (GO:0007638)2.72763184
110limb bud formation (GO:0060174)2.71394855
111regulation of mesoderm development (GO:2000380)2.71346914
112G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.71019826
113spindle assembly involved in mitosis (GO:0090307)2.70722015
114startle response (GO:0001964)2.69705276
115myelination in peripheral nervous system (GO:0022011)2.68946257
116peripheral nervous system axon ensheathment (GO:0032292)2.68946257
117synapse organization (GO:0050808)2.68235954
118neuronal ion channel clustering (GO:0045161)2.67867712
119positive regulation of glomerulus development (GO:0090193)2.67698551
120mating behavior (GO:0007617)2.67530659
121response to caffeine (GO:0031000)2.66985538
122cornea development in camera-type eye (GO:0061303)2.66478456
123regulation of synaptic vesicle transport (GO:1902803)2.66116118
124negative regulation of axon extension (GO:0030517)2.66094076
125protein complex biogenesis (GO:0070271)2.65896760
126dendrite development (GO:0016358)2.65673969
127nonmotile primary cilium assembly (GO:0035058)2.64923444
128negative chemotaxis (GO:0050919)2.64760814
129neuron-neuron synaptic transmission (GO:0007270)2.64669072
130cellular response to ATP (GO:0071318)2.64482248
131ventricular septum development (GO:0003281)2.64331039
132establishment of nucleus localization (GO:0040023)2.63097342
133central nervous system neuron axonogenesis (GO:0021955)2.62551596
134neurotransmitter-gated ion channel clustering (GO:0072578)2.62444001
135serotonin metabolic process (GO:0042428)2.61917744
136urinary tract smooth muscle contraction (GO:0014848)2.61852101
137negative regulation of Rho protein signal transduction (GO:0035024)2.61790529
138otic vesicle formation (GO:0030916)2.61585663
139dendritic spine organization (GO:0097061)2.60785918
140regulation of axon extension (GO:0030516)2.60660039
141kidney morphogenesis (GO:0060993)2.60556884
142organelle transport along microtubule (GO:0072384)2.60103625
143adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.58741908
144positive regulation of action potential (GO:0045760)2.58615813
145neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.58232213
146cerebellar granule cell differentiation (GO:0021707)2.58137607
147neuronal action potential propagation (GO:0019227)2.57658924
148presynaptic membrane organization (GO:0097090)2.55362809
149dopamine receptor signaling pathway (GO:0007212)2.55322043
150regulation of synapse assembly (GO:0051963)2.55189979
151activation of protein kinase A activity (GO:0034199)2.54872611
152regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.53873658
153ovulation cycle (GO:0042698)2.52813030
154hindbrain development (GO:0030902)2.52654942
155mitochondrion morphogenesis (GO:0070584)2.51876709
156sympathetic nervous system development (GO:0048485)2.51874167
157negative regulation of cytosolic calcium ion concentration (GO:0051481)2.51704697
158long-term memory (GO:0007616)2.51684043
159endoderm formation (GO:0001706)2.50435489
160neuron projection morphogenesis (GO:0048812)2.48719685
161epithelial cell differentiation involved in kidney development (GO:0035850)2.48717053
162regulation of synapse organization (GO:0050807)2.48459958
163negative regulation of catenin import into nucleus (GO:0035414)2.48083967
164embryonic epithelial tube formation (GO:0001838)2.47611697
165positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.47074831
166membrane depolarization during action potential (GO:0086010)2.46586313
167cell communication by electrical coupling (GO:0010644)2.46360453
168homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.45546202
169membrane hyperpolarization (GO:0060081)2.45449350
170regulation of oligodendrocyte differentiation (GO:0048713)2.44896161
171regulation of respiratory system process (GO:0044065)2.44701369
172DNA deamination (GO:0045006)2.44236358
173indole-containing compound metabolic process (GO:0042430)2.43863898
174primary amino compound metabolic process (GO:1901160)2.43743865
175response to pheromone (GO:0019236)2.43390054
176positive regulation of cardiac muscle cell differentiation (GO:2000727)2.42087092
177regulation of glomerulus development (GO:0090192)2.41771329
178positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.41528296
179cilium morphogenesis (GO:0060271)2.41515447
180dermatan sulfate biosynthetic process (GO:0030208)2.40985813
181photoreceptor cell development (GO:0042461)2.40820694
182epithelial cilium movement (GO:0003351)2.38861174
183pharyngeal system development (GO:0060037)2.36991764
184action potential (GO:0001508)2.36200775
185negative regulation of transcription regulatory region DNA binding (GO:2000678)2.36091334
186negative regulation of protein localization to cell surface (GO:2000009)2.34590309

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.16992500
2GBX2_23144817_ChIP-Seq_PC3_Human3.00948354
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89367971
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88937718
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.81079796
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.74604298
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.73934124
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.73934124
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.57751496
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48808533
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.48290717
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47990822
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46681510
14VDR_22108803_ChIP-Seq_LS180_Human2.30264066
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29310884
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.27787125
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.26150265
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.26104881
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23607403
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20526606
21REST_21632747_ChIP-Seq_MESCs_Mouse2.00761657
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.99935320
23FUS_26573619_Chip-Seq_HEK293_Human1.98975136
24DROSHA_22980978_ChIP-Seq_HELA_Human1.95714519
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.84192019
26PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.79721422
27AR_21572438_ChIP-Seq_LNCaP_Human1.76349320
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75197599
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72760601
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69783624
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.69118390
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.67329944
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65735466
34RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63911193
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63533702
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62564623
37EWS_26573619_Chip-Seq_HEK293_Human1.59267788
38ER_23166858_ChIP-Seq_MCF-7_Human1.58914696
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.58606327
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54177050
41ZNF274_21170338_ChIP-Seq_K562_Hela1.53047608
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.50998466
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.49801124
44RING1B_27294783_Chip-Seq_ESCs_Mouse1.47191393
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45859047
46* SMAD4_21799915_ChIP-Seq_A2780_Human1.44806591
47RING1B_27294783_Chip-Seq_NPCs_Mouse1.44801502
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41704044
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40886195
50RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39624976
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39186019
52* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39169602
53TAF15_26573619_Chip-Seq_HEK293_Human1.38657562
54BCAT_22108803_ChIP-Seq_LS180_Human1.38508349
55IRF1_19129219_ChIP-ChIP_H3396_Human1.37814211
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.37720677
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37695172
58TP63_19390658_ChIP-ChIP_HaCaT_Human1.36913156
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35660671
60* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34849871
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.34747152
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.33390932
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33119877
64* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32607315
65RNF2_27304074_Chip-Seq_NSC_Mouse1.32592567
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30544792
67* AHR_22903824_ChIP-Seq_MCF-7_Human1.30109580
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29252176
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27324958
70TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.26585091
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.26555295
72P300_19829295_ChIP-Seq_ESCs_Human1.26255120
73WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25607390
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25568811
75* ARNT_22903824_ChIP-Seq_MCF-7_Human1.24772562
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24211865
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23828631
78* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20950859
79MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20881805
80NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20749181
81* SOX2_21211035_ChIP-Seq_LN229_Gbm1.20258968
82CBP_20019798_ChIP-Seq_JUKART_Human1.18401185
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18401185
84RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17496560
85KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16630475
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16009902
87TP53_20018659_ChIP-ChIP_R1E_Mouse1.15958905
88POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15696672
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14336054
90EP300_21415370_ChIP-Seq_HL-1_Mouse1.13983370
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13950494
92AR_19668381_ChIP-Seq_PC3_Human1.13481402
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.12826047
94RXR_22108803_ChIP-Seq_LS180_Human1.12175068
95* KDM2B_26808549_Chip-Seq_K562_Human1.11491686
96* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10724534
97* STAT3_23295773_ChIP-Seq_U87_Human1.10658971
98FLI1_27457419_Chip-Seq_LIVER_Mouse1.09126272
99PRDM14_20953172_ChIP-Seq_ESCs_Human1.08074265
100SMAD_19615063_ChIP-ChIP_OVARY_Human1.07098914
101* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06823936
102ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06778709
103WT1_19549856_ChIP-ChIP_CCG9911_Human1.06172284
104AR_25329375_ChIP-Seq_VCAP_Human1.05602072
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05040578
106* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05012771
107EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04683690
108BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04476788
109SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03990609
110TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03795819
111KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03167369
112TRIM28_21343339_ChIP-Seq_HEK293_Human1.03015674
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02607095
114* TP53_18474530_ChIP-ChIP_U2OS_Human1.02289057
115FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02156617
116SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02154559
117CJUN_26792858_Chip-Seq_BT549_Human1.02146082
118TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01992881
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01992881
120* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01416467
121* TCF4_22108803_ChIP-Seq_LS180_Human1.01077119
122JUN_21703547_ChIP-Seq_K562_Human1.00885519
123* RUNX2_22187159_ChIP-Seq_PCA_Human0.99964245
124MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97648351
125SMAD4_21741376_ChIP-Seq_HESCs_Human0.97242724
126ISL1_27105846_Chip-Seq_CPCs_Mouse0.96840264
127* SMAD3_21741376_ChIP-Seq_ESCs_Human0.96475021
128GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95918372
129P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95735120
130* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94563239
131IGF1R_20145208_ChIP-Seq_DFB_Human0.93899036
132TCF4_18268006_ChIP-ChIP_LS174T_Human0.93133350
133TCF4_23295773_ChIP-Seq_U87_Human0.93050124
134POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91596709
135TP53_16413492_ChIP-PET_HCT116_Human0.91554926

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.17706154
2MP0004270_analgesia3.21697181
3MP0003880_abnormal_central_pattern3.09098366
4MP0005423_abnormal_somatic_nervous3.00256709
5MP0005670_abnormal_white_adipose2.94501508
6MP0003635_abnormal_synaptic_transmissio2.92111229
7MP0000778_abnormal_nervous_system2.64944381
8MP0002063_abnormal_learning/memory/cond2.41976123
9MP0002734_abnormal_mechanical_nocicepti2.37734090
10MP0006292_abnormal_olfactory_placode2.23414508
11MP0006276_abnormal_autonomic_nervous2.21248344
12MP0001968_abnormal_touch/_nociception2.19264134
13MP0002184_abnormal_innervation2.16613351
14MP0009745_abnormal_behavioral_response2.11898912
15MP0001486_abnormal_startle_reflex2.10119732
16MP0003122_maternal_imprinting2.06478652
17MP0000516_abnormal_urinary_system2.04639731
18MP0005367_renal/urinary_system_phenotyp2.04639731
19MP0002572_abnormal_emotion/affect_behav2.02813798
20MP0004858_abnormal_nervous_system1.99073368
21MP0009046_muscle_twitch1.97638426
22MP0002653_abnormal_ependyma_morphology1.96694386
23MP0005623_abnormal_meninges_morphology1.88831893
24MP0002064_seizures1.87829436
25MP0002735_abnormal_chemical_nociception1.87558964
26MP0005551_abnormal_eye_electrophysiolog1.83903416
27MP0002733_abnormal_thermal_nociception1.77035196
28MP0004885_abnormal_endolymph1.70487891
29MP0000569_abnormal_digit_pigmentation1.69941524
30MP0002557_abnormal_social/conspecific_i1.66278266
31MP0002160_abnormal_reproductive_system1.65848173
32MP0004133_heterotaxia1.62448658
33MP0002272_abnormal_nervous_system1.61515577
34MP0002822_catalepsy1.60687172
35MP0000955_abnormal_spinal_cord1.59303616
36MP0004142_abnormal_muscle_tone1.59256187
37MP0003136_yellow_coat_color1.58574678
38MP0009780_abnormal_chondrocyte_physiolo1.58560583
39MP0002736_abnormal_nociception_after1.57842086
40MP0001970_abnormal_pain_threshold1.54735923
41MP0003283_abnormal_digestive_organ1.52965600
42MP0000537_abnormal_urethra_morphology1.52763866
43MP0004811_abnormal_neuron_physiology1.52048483
44MP0005645_abnormal_hypothalamus_physiol1.50596663
45MP0002067_abnormal_sensory_capabilities1.50346271
46MP0003315_abnormal_perineum_morphology1.50138298
47MP0004272_abnormal_basement_membrane1.49551076
48MP0003385_abnormal_body_wall1.48663908
49MP0008877_abnormal_DNA_methylation1.47817798
50MP0001188_hyperpigmentation1.47700840
51MP0004130_abnormal_muscle_cell1.46636125
52MP0002282_abnormal_trachea_morphology1.44427631
53MP0000383_abnormal_hair_follicle1.43985983
54MP0002882_abnormal_neuron_morphology1.43029109
55MP0001440_abnormal_grooming_behavior1.42254160
56MP0002938_white_spotting1.37035200
57MP0001984_abnormal_olfaction1.37000029
58MP0000534_abnormal_ureter_morphology1.35642968
59MP0003890_abnormal_embryonic-extraembry1.34642056
60MP0002876_abnormal_thyroid_physiology1.33162551
61MP0003195_calcinosis1.32302430
62MP0001299_abnormal_eye_distance/1.31030315
63MP0004924_abnormal_behavior1.29757068
64MP0005386_behavior/neurological_phenoty1.29757068
65MP0002152_abnormal_brain_morphology1.28893023
66MP0008569_lethality_at_weaning1.27265976
67MP0003942_abnormal_urinary_system1.26717465
68MP0005253_abnormal_eye_physiology1.24864318
69MP0003787_abnormal_imprinting1.23421580
70MP0005174_abnormal_tail_pigmentation1.22372928
71MP0002837_dystrophic_cardiac_calcinosis1.21153167
72MP0005195_abnormal_posterior_eye1.21041873
73MP0005187_abnormal_penis_morphology1.20978836
74MP0009384_cardiac_valve_regurgitation1.20873237
75MP0001529_abnormal_vocalization1.19244582
76MP0008872_abnormal_physiological_respon1.18358872
77MP0000631_abnormal_neuroendocrine_gland1.17735222
78MP0005499_abnormal_olfactory_system1.17200161
79MP0005394_taste/olfaction_phenotype1.17200161
80MP0003861_abnormal_nervous_system1.15971996
81MP0002066_abnormal_motor_capabilities/c1.14522541
82MP0004742_abnormal_vestibular_system1.13299243
83MP0002909_abnormal_adrenal_gland1.13267012
84MP0003646_muscle_fatigue1.13106206
85MP0009250_abnormal_appendicular_skeleto1.12648733
86MP0001501_abnormal_sleep_pattern1.10454256
87MP0005389_reproductive_system_phenotype1.09824283
88MP0005409_darkened_coat_color1.08673423
89MP0000427_abnormal_hair_cycle1.08304785
90MP0008789_abnormal_olfactory_epithelium1.08083144
91MP0005646_abnormal_pituitary_gland1.05056823
92MP0002752_abnormal_somatic_nervous1.03910076
93MP0001485_abnormal_pinna_reflex1.03441439
94MP0001905_abnormal_dopamine_level1.00263533
95MP0003121_genomic_imprinting0.99026826
96MP0003329_amyloid_beta_deposits0.98471153
97MP0003634_abnormal_glial_cell0.98031068
98MP0002928_abnormal_bile_duct0.97880245
99MP0003011_delayed_dark_adaptation0.96919027
100MP0005248_abnormal_Harderian_gland0.93352970
101MP0000026_abnormal_inner_ear0.92775904
102MP0003755_abnormal_palate_morphology0.92281224
103MP0001963_abnormal_hearing_physiology0.91918493
104MP0002234_abnormal_pharynx_morphology0.91785315
105MP0002233_abnormal_nose_morphology0.89734774
106MP0000013_abnormal_adipose_tissue0.89555989
107MP0002751_abnormal_autonomic_nervous0.89474386
108MP0004085_abnormal_heartbeat0.88787227
109MP0010386_abnormal_urinary_bladder0.87360603
110MP0003936_abnormal_reproductive_system0.86541464
111MP0002116_abnormal_craniofacial_bone0.86379073
112MP0003119_abnormal_digestive_system0.86163394
113MP0000049_abnormal_middle_ear0.85657081
114MP0003938_abnormal_ear_development0.85527540
115MP0000462_abnormal_digestive_system0.84362114
116MP0001502_abnormal_circadian_rhythm0.84151857
117MP0006072_abnormal_retinal_apoptosis0.83873405
118MP0010368_abnormal_lymphatic_system0.83814785
119MP0001661_extended_life_span0.83573530
120MP0003879_abnormal_hair_cell0.82248585
121MP0000751_myopathy0.81855172
122MP0003137_abnormal_impulse_conducting0.80970425
123MP0002081_perinatal_lethality0.80661999
124MP0002249_abnormal_larynx_morphology0.79947179
125MP0005503_abnormal_tendon_morphology0.79808270
126MP0002102_abnormal_ear_morphology0.79806778
127MP0002638_abnormal_pupillary_reflex0.79709583
128MP0000230_abnormal_systemic_arterial0.79388579
129MP0009053_abnormal_anal_canal0.78944980
130MP0003941_abnormal_skin_development0.77300764
131MP0001879_abnormal_lymphatic_vessel0.76338654
132MP0005171_absent_coat_pigmentation0.76265042
133MP0003937_abnormal_limbs/digits/tail_de0.74580314
134MP0003935_abnormal_craniofacial_develop0.74021725

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)5.09398848
2Short 1st metacarpal (HP:0010034)5.09398848
3Abnormality of the 1st metacarpal (HP:0010009)4.44571792
4Myokymia (HP:0002411)4.12496126
5Stenosis of the external auditory canal (HP:0000402)4.04602289
6Pancreatic cysts (HP:0001737)3.63605006
7Short phalanx of the thumb (HP:0009660)3.49931496
8True hermaphroditism (HP:0010459)3.49768203
9Short hallux (HP:0010109)3.43264808
10Pancreatic fibrosis (HP:0100732)3.40296373
11Focal seizures (HP:0007359)3.38583996
12Limb dystonia (HP:0002451)3.35163659
13Focal motor seizures (HP:0011153)3.32807073
14Abnormality of midbrain morphology (HP:0002418)3.29997578
15Molar tooth sign on MRI (HP:0002419)3.29997578
16Ectopic kidney (HP:0000086)3.24991567
17Aplasia/Hypoplasia of the hallux (HP:0008362)3.22020695
18Pendular nystagmus (HP:0012043)3.15946393
19Nephronophthisis (HP:0000090)3.11839185
20Action tremor (HP:0002345)2.93906971
21Abnormality of the nasal septum (HP:0000419)2.92850259
22Congenital sensorineural hearing impairment (HP:0008527)2.91609974
23Insidious onset (HP:0003587)2.91539626
24Termporal pattern (HP:0011008)2.91539626
25Increased corneal curvature (HP:0100692)2.82632842
26Keratoconus (HP:0000563)2.82632842
27Congenital stationary night blindness (HP:0007642)2.80744909
28Progressive cerebellar ataxia (HP:0002073)2.80126951
29Hyperventilation (HP:0002883)2.78443862
30Supranuclear gaze palsy (HP:0000605)2.77641634
31Abnormality of the renal collecting system (HP:0004742)2.74379349
32Ankle clonus (HP:0011448)2.70905073
33Synostosis of carpal bones (HP:0005048)2.68498113
34Chorioretinal atrophy (HP:0000533)2.68262402
35Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.67199467
36Visual hallucinations (HP:0002367)2.67060767
37Megalencephaly (HP:0001355)2.65345070
38Fused cervical vertebrae (HP:0002949)2.63786284
39Abnormality of the renal medulla (HP:0100957)2.62569697
40Aplasia/Hypoplasia involving the musculature (HP:0001460)2.59900017
41Mutism (HP:0002300)2.55552446
42Abnormality of the corticospinal tract (HP:0002492)2.52488602
43Severe muscular hypotonia (HP:0006829)2.50706407
44Carpal bone hypoplasia (HP:0001498)2.48339690
45Abnormality of the proximal phalanges of the hand (HP:0009834)2.46455105
46Cystic liver disease (HP:0006706)2.46365978
47Broad-based gait (HP:0002136)2.45354365
48Absent thumb (HP:0009777)2.40935223
49Abolished electroretinogram (ERG) (HP:0000550)2.39894283
50Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.38139791
51Epileptic encephalopathy (HP:0200134)2.38056804
52Ulnar claw (HP:0001178)2.36881802
53Drooling (HP:0002307)2.34308781
54Excessive salivation (HP:0003781)2.34308781
55Decreased subcutaneous fat (HP:0001002)2.33289045
56Oligomenorrhea (HP:0000876)2.28251399
57Gaze-evoked nystagmus (HP:0000640)2.27868883
58Atonic seizures (HP:0010819)2.26218578
59Midline defect of the nose (HP:0004122)2.25656616
60Cutaneous finger syndactyly (HP:0010554)2.24981962
61Morphological abnormality of the middle ear (HP:0008609)2.23951256
62Febrile seizures (HP:0002373)2.22395215
63Aplasia/Hypoplasia of the tibia (HP:0005772)2.20026483
64Chronic hepatic failure (HP:0100626)2.17795691
65Duplicated collecting system (HP:0000081)2.17088013
66Medial flaring of the eyebrow (HP:0010747)2.15674393
67Neurofibrillary tangles (HP:0002185)2.13464654
68Sclerocornea (HP:0000647)2.12852545
69Agitation (HP:0000713)2.12763621
70Type II lissencephaly (HP:0007260)2.11434387
71Hepatoblastoma (HP:0002884)2.11407661
72Tented upper lip vermilion (HP:0010804)2.10347902
73Hemiparesis (HP:0001269)2.09125498
74Abnormality of DNA repair (HP:0003254)2.09059993
75Tubular atrophy (HP:0000092)2.08708083
76Amyotrophic lateral sclerosis (HP:0007354)2.08400724
77Genetic anticipation (HP:0003743)2.08051280
78Preaxial foot polydactyly (HP:0001841)2.07601659
79Focal segmental glomerulosclerosis (HP:0000097)2.05889121
80Cerebral inclusion bodies (HP:0100314)2.04066557
81Aplasia/Hypoplasia of the tongue (HP:0010295)2.03864805
82Exotropia (HP:0000577)2.03785006
83Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.03624331
84Short 4th metacarpal (HP:0010044)2.03624331
85Aplasia involving bones of the extremities (HP:0009825)2.02790765
86Aplasia involving bones of the upper limbs (HP:0009823)2.02790765
87Aplasia of the phalanges of the hand (HP:0009802)2.02790765
88Aplasia/Hypoplasia of the brainstem (HP:0007362)2.01941978
89Hypoplasia of the brainstem (HP:0002365)2.01941978
90Abnormality of the middle phalanges of the toes (HP:0010183)2.01846821
91Maternal diabetes (HP:0009800)2.01185051
92Abnormality of the renal cortex (HP:0011035)2.00405969
93Amblyopia (HP:0000646)1.99761369
94Gait imbalance (HP:0002141)1.98937510
95Aqueductal stenosis (HP:0002410)1.98653379
96Absent radius (HP:0003974)1.98075968
97Absent forearm bone (HP:0003953)1.97178301
98Aplasia involving forearm bones (HP:0009822)1.97178301
99Protruding tongue (HP:0010808)1.96038526
100Urinary bladder sphincter dysfunction (HP:0002839)1.95859740
101Overgrowth (HP:0001548)1.95821922
102Bony spicule pigmentary retinopathy (HP:0007737)1.94019228
103Generalized tonic-clonic seizures (HP:0002069)1.93854037
104Small hand (HP:0200055)1.93133964
105Cutaneous syndactyly (HP:0012725)1.93076224
106Short thumb (HP:0009778)1.92953795
107Apathy (HP:0000741)1.92691546
108Bronchomalacia (HP:0002780)1.92456000
109Short humerus (HP:0005792)1.91787407
110Hypoplasia of the ulna (HP:0003022)1.91573317
111Absent eyebrow (HP:0002223)1.91140726
112Concave nail (HP:0001598)1.89140471
113Anencephaly (HP:0002323)1.89020497
114Torticollis (HP:0000473)1.88789286
115Truncal ataxia (HP:0002078)1.87066505
116Tachypnea (HP:0002789)1.86753255
117Aplasia/Hypoplasia of the patella (HP:0006498)1.86115840
118Congenital, generalized hypertrichosis (HP:0004540)1.85898085
119Papilledema (HP:0001085)1.85543988
120Polyphagia (HP:0002591)1.85518874
121Esotropia (HP:0000565)1.85257785
122Absence seizures (HP:0002121)1.85194748
123Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.84163787
124Hyperthyroidism (HP:0000836)1.83849937
125Coronal craniosynostosis (HP:0004440)1.83569941
126Absent/shortened dynein arms (HP:0200106)1.83501399
127Dynein arm defect of respiratory motile cilia (HP:0012255)1.83501399
128Symphalangism affecting the phalanges of the hand (HP:0009773)1.82938135
129Abnormal ciliary motility (HP:0012262)1.82830178
130Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.82768050
131Abnormality of the carotid arteries (HP:0005344)1.82400534
132Preaxial hand polydactyly (HP:0001177)1.81487625
133Synostosis involving the elbow (HP:0003938)1.81217151
134Humeroradial synostosis (HP:0003041)1.81217151
135Buphthalmos (HP:0000557)1.79965710
136Insomnia (HP:0100785)1.79076309
137Wide intermamillary distance (HP:0006610)1.78930410
138Renal duplication (HP:0000075)1.78760068
139Abnormality of alanine metabolism (HP:0010916)1.78602003
140Hyperalaninemia (HP:0003348)1.78602003
141Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.78602003
142Akinesia (HP:0002304)1.78259602
143Abnormal eating behavior (HP:0100738)1.77895438
144Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.77661244
145Inability to walk (HP:0002540)1.76992357
146Aplasia/hypoplasia of the humerus (HP:0006507)1.76686148
147Poor eye contact (HP:0000817)1.76479176
148Hypoventilation (HP:0002791)1.75876579
149Carpal synostosis (HP:0009702)1.75430533
150Congenital primary aphakia (HP:0007707)1.75154239
151Stereotypic behavior (HP:0000733)1.74971933
152Long nose (HP:0003189)1.74862480
153Patellar aplasia (HP:0006443)1.73737588
154Optic nerve hypoplasia (HP:0000609)1.72575529
155Lower limb muscle weakness (HP:0007340)1.72497163
156EEG with generalized epileptiform discharges (HP:0011198)1.71846047
157Impaired vibration sensation in the lower limbs (HP:0002166)1.71169295
158Depression (HP:0000716)1.71082260
159Urinary urgency (HP:0000012)1.69438518
160Hypsarrhythmia (HP:0002521)1.69317330
161Intellectual disability, moderate (HP:0002342)1.68772827
162Lissencephaly (HP:0001339)1.68107622
163Neoplasm of the heart (HP:0100544)1.67563921
164Sacral dimple (HP:0000960)1.66572948
165Pachygyria (HP:0001302)1.66184211
166Rapidly progressive (HP:0003678)1.65878583
167Epileptiform EEG discharges (HP:0011182)1.65760727
168Spastic gait (HP:0002064)1.65669013
169Inappropriate behavior (HP:0000719)1.62806172
170Dysdiadochokinesis (HP:0002075)1.62531956
171Dialeptic seizures (HP:0011146)1.61791427
172Anxiety (HP:0000739)1.61436764
173Diminished motivation (HP:0000745)1.60526999
174Impaired social interactions (HP:0000735)1.60236695
175Abnormal social behavior (HP:0012433)1.60236695
176Obstructive sleep apnea (HP:0002870)1.59872079
177Shallow orbits (HP:0000586)1.59593190
178Abnormality of the lower motor neuron (HP:0002366)1.59194757
179Morphological abnormality of the pyramidal tract (HP:0002062)1.59152738
180Abnormality of binocular vision (HP:0011514)1.59067187
181Diplopia (HP:0000651)1.59067187
182Abnormality of salivation (HP:0100755)1.58118106
183Focal dystonia (HP:0004373)1.57258014
184Pointed chin (HP:0000307)1.56568025
185Absent speech (HP:0001344)1.55338092
186Narrow nasal bridge (HP:0000446)1.55284141
187Anteriorly placed anus (HP:0001545)1.55091940
188Prolonged QT interval (HP:0001657)1.54811675
189Sporadic (HP:0003745)1.53754614
190Overriding aorta (HP:0002623)1.52496271

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.71501517
2FRK5.23132758
3GRK13.21166154
4NTRK32.90897647
5MAP3K92.86845064
6NTRK22.69239232
7ADRBK22.65882349
8MAP3K42.57616802
9EPHB22.52994525
10MAPK132.32073809
11MINK12.28280942
12EPHA42.21003381
13ACVR1B2.17433963
14TLK12.10015130
15DYRK21.94699888
16LATS21.91955891
17MAP2K71.88171208
18CASK1.85804149
19ERBB31.84829371
20PHKG21.81920131
21PHKG11.81920131
22MAP4K21.81827474
23NTRK11.79315644
24PRKD31.69154067
25PINK11.63349566
26PAK61.61470976
27SIK21.49631218
28NUAK11.45186608
29ZAK1.44322266
30PNCK1.42693593
31KSR11.35713956
32CDK51.34834720
33UHMK11.33040436
34MAP2K41.22996678
35TYRO31.22667698
36LMTK21.22159231
37CDK91.18491362
38MKNK21.14633173
39DAPK21.13404108
40WNK31.12169369
41MAP3K21.10382315
42KSR21.09894646
43PAK31.08208306
44CSNK1G21.07232553
45TAOK11.05887527
46MARK21.04990930
47PLK21.04860209
48PDGFRA1.00568760
49CAMK1G0.98706655
50MAPK150.97673066
51SGK4940.95017205
52SGK2230.95017205
53DDR20.94834968
54FGFR20.93689879
55RIPK10.91738774
56TNIK0.90787224
57RET0.90483796
58CDK140.90117419
59STK110.90013147
60PRPF4B0.89380636
61EPHA30.89334044
62LIMK10.89195611
63CDK180.86502245
64CDK150.86301751
65GRK50.86116804
66PIK3CA0.83716321
67DYRK1A0.83565041
68PRKCG0.83214690
69MUSK0.82548476
70TGFBR10.82237742
71CAMKK10.81703079
72CSNK1A1L0.81097660
73AKT30.81008395
74WNK40.79718682
75DYRK30.79637453
76CAMK2B0.79323304
77PKN10.78267314
78FER0.76492510
79CDK11A0.76219945
80CAMK2A0.76072192
81BCR0.74896507
82CSNK1G30.73334156
83RPS6KA20.72320999
84STK38L0.71665741
85STK380.71324241
86TRIM280.71113152
87ROCK10.70913051
88PRKCE0.67581890
89SGK20.67152069
90ICK0.66970933
91WNK10.65814088
92PRKCZ0.65738854
93CDC42BPA0.64553875
94PRKD20.64407135
95PRKCH0.64002005
96STK390.62607388
97OXSR10.62160520
98INSRR0.59234546
99MAP3K120.56760797
100ERBB20.56285837
101CAMKK20.55828136
102CSNK1G10.55783579
103CSNK1A10.53929589
104GRK70.52809491
105CSNK1D0.51602395
106NEK20.50695547
107SGK10.49894602
108PRKACA0.48207078
109FYN0.48152547
110LATS10.47961460
111PRKAA10.46297024
112PTK2B0.46155727
113PTK20.45080780
114CHUK0.44635428
115MAPK90.44596680
116ADRBK10.44476115
117WEE10.44066117
118BMPR1B0.43438178
119ROCK20.42924365
120BRSK20.42915466
121SGK30.41430172
122TAOK30.40973442
123MAP2K10.40684671
124RPS6KA50.40374741
125RPS6KA60.40114144
126MAPK100.38901167
127NEK90.38682865
128MAPK80.38284935
129RPS6KA30.38182451
130ERBB40.38173109
131FLT30.37304159
132PDGFRB0.37193713
133TIE10.36098512
134FGFR10.35448822
135CAMK10.35378626
136FES0.35208764
137PRKG10.35086018
138CDC70.34480419
139MET0.34118871
140VRK10.32648259
141MAPKAPK50.31364761
142CAMK2D0.31295373
143PRKCI0.29744605
144CHEK20.29133743
145PRKCA0.28745123
146ABL20.28447915

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.67813209
2Olfactory transduction_Homo sapiens_hsa047402.28836429
3* Axon guidance_Homo sapiens_hsa043602.22859917
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.20098685
5GABAergic synapse_Homo sapiens_hsa047272.18091793
6Circadian entrainment_Homo sapiens_hsa047132.13234716
7Synaptic vesicle cycle_Homo sapiens_hsa047212.10983879
8Glutamatergic synapse_Homo sapiens_hsa047242.09182188
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.06686175
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.05980458
11Morphine addiction_Homo sapiens_hsa050322.00209806
12Dopaminergic synapse_Homo sapiens_hsa047282.00059986
13Nitrogen metabolism_Homo sapiens_hsa009101.97264062
14Long-term potentiation_Homo sapiens_hsa047201.91200511
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.86160971
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.85159080
17Cocaine addiction_Homo sapiens_hsa050301.84246380
18Linoleic acid metabolism_Homo sapiens_hsa005911.84000235
19Selenocompound metabolism_Homo sapiens_hsa004501.83584557
20Sulfur metabolism_Homo sapiens_hsa009201.83371314
21Amphetamine addiction_Homo sapiens_hsa050311.82528326
22Cholinergic synapse_Homo sapiens_hsa047251.80395260
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.77184935
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.73713774
25Insulin secretion_Homo sapiens_hsa049111.72775222
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.70513119
27Taste transduction_Homo sapiens_hsa047421.68803222
28Serotonergic synapse_Homo sapiens_hsa047261.68484141
29Gap junction_Homo sapiens_hsa045401.64660772
30Long-term depression_Homo sapiens_hsa047301.57353702
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55166995
32Salivary secretion_Homo sapiens_hsa049701.53947225
33Renin secretion_Homo sapiens_hsa049241.53404927
34Butanoate metabolism_Homo sapiens_hsa006501.51831037
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48606056
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44003519
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43417076
38Gastric acid secretion_Homo sapiens_hsa049711.43287488
39Fanconi anemia pathway_Homo sapiens_hsa034601.37988675
40Ether lipid metabolism_Homo sapiens_hsa005651.36859454
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.33140845
42GnRH signaling pathway_Homo sapiens_hsa049121.30406107
43Oxytocin signaling pathway_Homo sapiens_hsa049211.29529132
44Tryptophan metabolism_Homo sapiens_hsa003801.29052238
45Melanogenesis_Homo sapiens_hsa049161.28869782
46ErbB signaling pathway_Homo sapiens_hsa040121.26379403
47Hedgehog signaling pathway_Homo sapiens_hsa043401.24559926
48Estrogen signaling pathway_Homo sapiens_hsa049151.24509580
49Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.21266700
50Glioma_Homo sapiens_hsa052141.20911841
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.19827744
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.19097698
53Chemical carcinogenesis_Homo sapiens_hsa052041.18078045
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.17268815
55Dorso-ventral axis formation_Homo sapiens_hsa043201.13806597
56Endometrial cancer_Homo sapiens_hsa052131.13276425
57Dilated cardiomyopathy_Homo sapiens_hsa054141.11602570
58cAMP signaling pathway_Homo sapiens_hsa040241.10336877
59Steroid hormone biosynthesis_Homo sapiens_hsa001401.09216568
60Type II diabetes mellitus_Homo sapiens_hsa049301.08929471
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08759425
62Calcium signaling pathway_Homo sapiens_hsa040201.08070851
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07940579
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05714408
65Wnt signaling pathway_Homo sapiens_hsa043101.03601067
66RNA polymerase_Homo sapiens_hsa030201.03027651
67Basal cell carcinoma_Homo sapiens_hsa052171.02698843
68Basal transcription factors_Homo sapiens_hsa030221.01662735
69Renal cell carcinoma_Homo sapiens_hsa052111.00296813
70Glycerolipid metabolism_Homo sapiens_hsa005610.99151252
71TGF-beta signaling pathway_Homo sapiens_hsa043500.97691735
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97590576
73Hippo signaling pathway_Homo sapiens_hsa043900.95358839
74Phototransduction_Homo sapiens_hsa047440.95330407
75ABC transporters_Homo sapiens_hsa020100.94060222
76Retinol metabolism_Homo sapiens_hsa008300.92096551
77Cardiac muscle contraction_Homo sapiens_hsa042600.91394794
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.91002518
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.90325804
80Oxidative phosphorylation_Homo sapiens_hsa001900.88099322
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.87378145
82Ras signaling pathway_Homo sapiens_hsa040140.87258498
83Oocyte meiosis_Homo sapiens_hsa041140.86905581
84Steroid biosynthesis_Homo sapiens_hsa001000.86758650
85Rap1 signaling pathway_Homo sapiens_hsa040150.86155195
86Colorectal cancer_Homo sapiens_hsa052100.86006312
87ECM-receptor interaction_Homo sapiens_hsa045120.85793482
88Tight junction_Homo sapiens_hsa045300.85182419
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84852652
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84234734
91Choline metabolism in cancer_Homo sapiens_hsa052310.84172762
92Homologous recombination_Homo sapiens_hsa034400.83756557
93Alzheimers disease_Homo sapiens_hsa050100.83067258
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81494523
95MAPK signaling pathway_Homo sapiens_hsa040100.80596679
96Focal adhesion_Homo sapiens_hsa045100.80299956
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79033402
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78102163
99Thyroid hormone synthesis_Homo sapiens_hsa049180.73917390
100Huntingtons disease_Homo sapiens_hsa050160.73657278
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.73394991
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72842831
103Vibrio cholerae infection_Homo sapiens_hsa051100.72567449
104Caffeine metabolism_Homo sapiens_hsa002320.71555627
105Sulfur relay system_Homo sapiens_hsa041220.70705192
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70115348
107Histidine metabolism_Homo sapiens_hsa003400.69809051
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68930653
109VEGF signaling pathway_Homo sapiens_hsa043700.66308855
110Alcoholism_Homo sapiens_hsa050340.66152431
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66012344
112Collecting duct acid secretion_Homo sapiens_hsa049660.65373273
113Fat digestion and absorption_Homo sapiens_hsa049750.65068523
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.64366387
115Circadian rhythm_Homo sapiens_hsa047100.63186123
116mTOR signaling pathway_Homo sapiens_hsa041500.62623080
117RNA degradation_Homo sapiens_hsa030180.62217968
118Adherens junction_Homo sapiens_hsa045200.61434675
119Renin-angiotensin system_Homo sapiens_hsa046140.59887481
120Pancreatic secretion_Homo sapiens_hsa049720.58711689
121Protein export_Homo sapiens_hsa030600.58617865
122Endocytosis_Homo sapiens_hsa041440.57857528
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57763652
124Melanoma_Homo sapiens_hsa052180.57050795
125Ovarian steroidogenesis_Homo sapiens_hsa049130.56793695
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56516062
127Proteoglycans in cancer_Homo sapiens_hsa052050.56162736
128Parkinsons disease_Homo sapiens_hsa050120.56037501
129Insulin signaling pathway_Homo sapiens_hsa049100.53682143
130Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53163973
131Amoebiasis_Homo sapiens_hsa051460.51133775
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50972221
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50677400
134Non-small cell lung cancer_Homo sapiens_hsa052230.50320219
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49429364
136Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49424870
137Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49333607
138Peroxisome_Homo sapiens_hsa041460.47152586
139beta-Alanine metabolism_Homo sapiens_hsa004100.46582436
140Pathways in cancer_Homo sapiens_hsa052000.46238734
141Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45103978
142Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44476397
143AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43325575
144Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42949017
145Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41254985
146Protein digestion and absorption_Homo sapiens_hsa049740.40041576
147Arachidonic acid metabolism_Homo sapiens_hsa005900.38304456
148Regulation of autophagy_Homo sapiens_hsa041400.37996927

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