SRGAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1microglial cell activation (GO:0001774)4.52869926
2modulation by symbiont of host defense response (GO:0052031)4.14157476
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.14157476
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.14157476
5positive regulation by organism of defense response of other organism involved in symbiotic interact4.14157476
6modulation by symbiont of host immune response (GO:0052553)4.14157476
7positive regulation by symbiont of host defense response (GO:0052509)4.14157476
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.92153116
9negative regulation of cell killing (GO:0031342)3.92153116
10cerebral cortex radially oriented cell migration (GO:0021799)3.87777598
11cornea development in camera-type eye (GO:0061303)3.84491878
12presynaptic membrane organization (GO:0097090)3.81695647
13macrophage activation involved in immune response (GO:0002281)3.77371206
14presynaptic membrane assembly (GO:0097105)3.74497472
15limb bud formation (GO:0060174)3.60587788
16positive regulation of neuroblast proliferation (GO:0002052)3.45671214
17regulation of interferon-beta biosynthetic process (GO:0045357)3.43389850
18regulation of ARF GTPase activity (GO:0032312)3.25437941
19positive regulation of chemokine secretion (GO:0090197)3.25030548
20dorsal/ventral axis specification (GO:0009950)3.22012568
21negative regulation of granulocyte differentiation (GO:0030853)3.20795617
22I-kappaB phosphorylation (GO:0007252)3.20419601
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.16869798
24cerebral cortex cell migration (GO:0021795)3.15625637
25layer formation in cerebral cortex (GO:0021819)3.08980024
26response to pheromone (GO:0019236)3.08791969
27synaptic vesicle docking involved in exocytosis (GO:0016081)3.08327289
28synaptic vesicle maturation (GO:0016188)3.07486801
29locomotory exploration behavior (GO:0035641)3.01078327
30regulation of sarcomere organization (GO:0060297)2.99527841
31postsynaptic membrane organization (GO:0001941)2.97185681
32glial cell proliferation (GO:0014009)2.95508680
33synaptic vesicle endocytosis (GO:0048488)2.93384804
34atrial cardiac muscle cell action potential (GO:0086014)2.91196894
35dendrite morphogenesis (GO:0048813)2.90728516
36cellular response to ethanol (GO:0071361)2.85316683
37clathrin coat assembly (GO:0048268)2.83404873
38regulation of timing of cell differentiation (GO:0048505)2.79971885
39cell-cell junction maintenance (GO:0045217)2.79071492
40neuron cell-cell adhesion (GO:0007158)2.77248062
41negative regulation of dendrite development (GO:2000171)2.75820682
42negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.73818936
43negative regulation of translation, ncRNA-mediated (GO:0040033)2.73818936
44regulation of translation, ncRNA-mediated (GO:0045974)2.73818936
45neuron recognition (GO:0008038)2.73770907
46response to host (GO:0075136)2.71388483
47response to host defenses (GO:0052200)2.71388483
48response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.71388483
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.70278783
50neurotransmitter-gated ion channel clustering (GO:0072578)2.69853933
51response to host immune response (GO:0052572)2.68303279
52response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.68303279
53olfactory bulb development (GO:0021772)2.68068226
54regulation of synapse structural plasticity (GO:0051823)2.67957749
55macrophage activation (GO:0042116)2.67578943
56establishment of nucleus localization (GO:0040023)2.67287430
57membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.65754378
58cerebellar Purkinje cell differentiation (GO:0021702)2.65695501
59regulation of glutamate receptor signaling pathway (GO:1900449)2.64625301
60cell junction maintenance (GO:0034331)2.62587398
61glycosphingolipid biosynthetic process (GO:0006688)2.62033703
62G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.61790970
63cardiac ventricle formation (GO:0003211)2.61569577
64regulation of axon guidance (GO:1902667)2.61032163
65regulation of short-term neuronal synaptic plasticity (GO:0048172)2.59181535
66chondroitin sulfate catabolic process (GO:0030207)2.59018648
67embryonic foregut morphogenesis (GO:0048617)2.58869330
68regulation of axon extension involved in axon guidance (GO:0048841)2.58152751
69neuronal action potential propagation (GO:0019227)2.57768603
70vocalization behavior (GO:0071625)2.56981127
71G-protein coupled receptor internalization (GO:0002031)2.56900263
72regulation of chemokine secretion (GO:0090196)2.56769840
73regulation of ARF protein signal transduction (GO:0032012)2.56494431
74neuronal ion channel clustering (GO:0045161)2.55278154
75DNA double-strand break processing (GO:0000729)2.53720531
76astrocyte differentiation (GO:0048708)2.52962591
77cortical actin cytoskeleton organization (GO:0030866)2.52587402
78positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.48224947
79limb development (GO:0060173)2.47985350
80appendage development (GO:0048736)2.47985350
81glutamate secretion (GO:0014047)2.47712115
82cellular response to fluid shear stress (GO:0071498)2.46507020
83hindbrain development (GO:0030902)2.46363724
84regulation of neuroblast proliferation (GO:1902692)2.46285327
85lens morphogenesis in camera-type eye (GO:0002089)2.45998307
86negative regulation of axon guidance (GO:1902668)2.45611485
87negative regulation of dendrite morphogenesis (GO:0050774)2.44352748
88positive regulation of cardiac muscle hypertrophy (GO:0010613)2.43941594
89positive regulation of muscle hypertrophy (GO:0014742)2.43941594
90response to auditory stimulus (GO:0010996)2.43759949
91positive regulation of cellular amide metabolic process (GO:0034250)2.43472194
92microtubule polymerization or depolymerization (GO:0031109)2.42887536
93artery development (GO:0060840)2.42764007
94cardiac chamber formation (GO:0003207)2.42445643
95ionotropic glutamate receptor signaling pathway (GO:0035235)2.41634829
96regulation of Rac protein signal transduction (GO:0035020)2.41468105
97histone H3-K4 trimethylation (GO:0080182)2.40795657
98regulation of dendritic spine development (GO:0060998)2.40778951
99regulation of synapse maturation (GO:0090128)2.40142015
100cellular potassium ion homeostasis (GO:0030007)2.39842073
101regulation of hypersensitivity (GO:0002883)2.39322592
102germ cell migration (GO:0008354)2.39216094
103centrosome duplication (GO:0051298)2.38163920
104germinal center formation (GO:0002467)2.38117736
105negative regulation of axon extension involved in axon guidance (GO:0048843)2.37385648
106regulation of chemokine-mediated signaling pathway (GO:0070099)2.36508662
107regulation of hippo signaling (GO:0035330)2.35228282
108neuromuscular process controlling balance (GO:0050885)2.34937037
109regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.34914167
110monocyte differentiation (GO:0030224)2.34280382
111cerebellar granule cell differentiation (GO:0021707)2.33864216
112semaphorin-plexin signaling pathway (GO:0071526)2.33294562
113substrate-dependent cell migration (GO:0006929)2.31745442
114kinetochore organization (GO:0051383)2.31595741
115retinal ganglion cell axon guidance (GO:0031290)2.31001391
116positive regulation of neural precursor cell proliferation (GO:2000179)2.30792212
117positive regulation of Rap GTPase activity (GO:0032854)2.30528893
118spinal cord development (GO:0021510)2.29709205
119response to lipoprotein particle (GO:0055094)2.29524413
120proline transport (GO:0015824)2.29281680
121regulation of development, heterochronic (GO:0040034)2.29073902
122response to muramyl dipeptide (GO:0032495)2.25756425
123cortical cytoskeleton organization (GO:0030865)2.25325181
124microtubule anchoring (GO:0034453)2.25208933
125positive regulation of synapse maturation (GO:0090129)2.23094983
126positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.22522582
127positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.22522582
128positive regulation of mitotic sister chromatid separation (GO:1901970)2.22522582
129mechanosensory behavior (GO:0007638)2.22236816
130L-amino acid import (GO:0043092)2.22014374
131cell proliferation in forebrain (GO:0021846)2.21582778
132regulation of B cell receptor signaling pathway (GO:0050855)2.21000811
133G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.20972365
134positive regulation of dendritic spine morphogenesis (GO:0061003)2.20617728
135cell migration in hindbrain (GO:0021535)2.18215852
136telencephalon cell migration (GO:0022029)2.18077219
137regulation of synaptic vesicle exocytosis (GO:2000300)2.18017876
138dendritic spine morphogenesis (GO:0060997)2.17962329
139positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.17750355
140sialylation (GO:0097503)2.17676121
141epithelial cell differentiation involved in kidney development (GO:0035850)2.17605001
142sodium ion export (GO:0071436)2.17294101
143positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.17248629
144establishment of protein localization to Golgi (GO:0072600)2.16831261
145amino acid import (GO:0043090)2.16788947
146cellular response to cholesterol (GO:0071397)2.15998350
147microtubule depolymerization (GO:0007019)2.15395288
148apoptotic cell clearance (GO:0043277)2.15342722
149axon extension (GO:0048675)2.14421980
150regulation of Rap GTPase activity (GO:0032317)2.13994685
151positive regulation of interferon-alpha production (GO:0032727)2.13985224
152forebrain cell migration (GO:0021885)2.13960975
153central nervous system neuron axonogenesis (GO:0021955)2.12682334
154positive regulation of fibroblast migration (GO:0010763)2.10079507
155regulation of germinal center formation (GO:0002634)2.09140132
156NLS-bearing protein import into nucleus (GO:0006607)2.08780887
157axonal fasciculation (GO:0007413)2.08372526
158cytoskeletal anchoring at plasma membrane (GO:0007016)2.07877118
159protein localization to synapse (GO:0035418)2.07186738
160nerve growth factor signaling pathway (GO:0038180)2.05809608
161positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.05430361
162glutamate receptor signaling pathway (GO:0007215)2.04753055
163regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.04044264
164regulation of NFAT protein import into nucleus (GO:0051532)2.03066410
165central nervous system projection neuron axonogenesis (GO:0021952)2.01580816
166regulation of interferon-alpha production (GO:0032647)2.01039126
167tolerance induction (GO:0002507)2.00443216
168exploration behavior (GO:0035640)1.99974025
169gamma-aminobutyric acid transport (GO:0015812)1.99961119
170embryonic viscerocranium morphogenesis (GO:0048703)1.99422147
171positive regulation of interferon-gamma biosynthetic process (GO:0045078)1.99419718
172synaptic vesicle exocytosis (GO:0016079)1.98654671
173cell adhesion mediated by integrin (GO:0033627)1.98633593

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZFP57_27257070_Chip-Seq_ESCs_Mouse2.60629099
2DROSHA_22980978_ChIP-Seq_HELA_Human2.51393594
3VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.47420403
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.45065346
5EZH2_22144423_ChIP-Seq_EOC_Human2.39212317
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.37779114
7GBX2_23144817_ChIP-Seq_PC3_Human2.28761248
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.25644017
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.13813842
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.03099262
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97492643
12TAF15_26573619_Chip-Seq_HEK293_Human1.96093733
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.96079229
14P300_19829295_ChIP-Seq_ESCs_Human1.93848594
15IRF8_27001747_Chip-Seq_BMDM_Mouse1.91956649
16CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86490093
17SMAD_19615063_ChIP-ChIP_OVARY_Human1.85051059
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.84521102
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.83638227
20* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.83481684
21EGR1_19374776_ChIP-ChIP_THP-1_Human1.80530032
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.78550404
23* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.76361572
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75311843
25SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.69910731
26* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69875130
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.69403317
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.69328871
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.63897977
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.63897977
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63700499
32FUS_26573619_Chip-Seq_HEK293_Human1.63223446
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.62387744
34TP53_16413492_ChIP-PET_HCT116_Human1.62323538
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.61466561
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.61253487
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.59746883
38* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59426464
39AR_21572438_ChIP-Seq_LNCaP_Human1.59163840
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57418030
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.55616294
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.55260288
43EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.54865696
44BCAT_22108803_ChIP-Seq_LS180_Human1.54179145
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.53766058
46KDM2B_26808549_Chip-Seq_K562_Human1.53713807
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.50515478
48WT1_19549856_ChIP-ChIP_CCG9911_Human1.47605481
49* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.47291379
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.47274568
51* AR_25329375_ChIP-Seq_VCAP_Human1.45009714
52ZNF274_21170338_ChIP-Seq_K562_Hela1.44608821
53* SPI1_23127762_ChIP-Seq_K562_Human1.44119088
54RARB_27405468_Chip-Seq_BRAIN_Mouse1.43024461
55TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42258248
56TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.41161867
57SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.40531105
58TCF4_23295773_ChIP-Seq_U87_Human1.40044217
59* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39730585
60* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38488796
61EWS_26573619_Chip-Seq_HEK293_Human1.38481065
62KDM2B_26808549_Chip-Seq_DND41_Human1.38076063
63* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37969973
64AHR_22903824_ChIP-Seq_MCF-7_Human1.37039637
65WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36229648
66BP1_19119308_ChIP-ChIP_Hs578T_Human1.35962611
67GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35933355
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35805523
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.35102879
70ER_23166858_ChIP-Seq_MCF-7_Human1.34409957
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34170720
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34004285
73CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.33366616
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33091899
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.32693338
76* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32509921
77SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.31903489
78STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.31678373
79RUNX_20019798_ChIP-Seq_JUKART_Human1.31463194
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31258978
81STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.31015928
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30788245
83VDR_24787735_ChIP-Seq_THP-1_Human1.30632077
84RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30145535
85LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29912638
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28155364
87JARID2_20075857_ChIP-Seq_MESCs_Mouse1.26861859
88DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.26533560
89REST_21632747_ChIP-Seq_MESCs_Mouse1.26267956
90* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25875225
91TP53_18474530_ChIP-ChIP_U2OS_Human1.25333410
92RUNX2_22187159_ChIP-Seq_PCA_Human1.24967313
93NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24779435
94* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24452008
95* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22428196
96CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.22313017
97FLI1_21867929_ChIP-Seq_TH2_Mouse1.21376235
98EZH2_27294783_Chip-Seq_ESCs_Mouse1.19959791
99EZH2_27304074_Chip-Seq_ESCs_Mouse1.19753767
100KDM2B_26808549_Chip-Seq_JURKAT_Human1.19216956
101TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.18992910
102* NANOG_18555785_Chip-Seq_ESCs_Mouse1.18141856
103NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.17393492
104VDR_22108803_ChIP-Seq_LS180_Human1.17172211
105EED_16625203_ChIP-ChIP_MESCs_Mouse1.15992603
106CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15791650
107SCL_19346495_ChIP-Seq_HPC-7_Human1.15768468
108STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15651288
109NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.14895418
110NRF2_20460467_ChIP-Seq_MEFs_Mouse1.14895418
111FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.14032025
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13999661
113FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13878498
114NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13650633
115RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13379905
116RNF2_27304074_Chip-Seq_NSC_Mouse1.13346761
117KDM2B_26808549_Chip-Seq_REH_Human1.13336271
118MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13247800
119ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13059254
120* TCF7_22412390_ChIP-Seq_EML_Mouse1.12815378
121SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12350503
122IGF1R_20145208_ChIP-Seq_DFB_Human1.11535773
123* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10603844
124TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09957649
125KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08346222
126SOX2_21211035_ChIP-Seq_LN229_Gbm1.06958015
127STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06072140
128CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05758769
129* SMAD4_21799915_ChIP-Seq_A2780_Human1.04801365
130SMAD3_21741376_ChIP-Seq_HESCs_Human1.04556960
131AR_19668381_ChIP-Seq_PC3_Human1.03065954
132NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02038361
133STAT3_23295773_ChIP-Seq_U87_Human1.01261228
134GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01047750
135EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99790810
136P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99718713
137AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99108409
138RING1B_27294783_Chip-Seq_NPCs_Mouse0.98988721
139POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98934991
140TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98934991
141SMAD4_21741376_ChIP-Seq_HESCs_Human0.97590369
142SMAD3_21741376_ChIP-Seq_ESCs_Human0.97562956
143GATA2_21666600_ChIP-Seq_HMVEC_Human0.96306498
144* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96239493
145* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95971369
146PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95344026
147SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.94670124
148KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94373672
149ISL1_27105846_Chip-Seq_CPCs_Mouse0.92263249
150* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91505405
151* SMAD3_21741376_ChIP-Seq_EPCs_Human0.90449421
152TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89283504
153ELK4_26923725_Chip-Seq_MESODERM_Mouse0.88704294

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.56775341
2MP0004859_abnormal_synaptic_plasticity4.24761299
3MP0003303_peritoneal_inflammation3.30338030
4MP0006292_abnormal_olfactory_placode3.24332662
5MP0003172_abnormal_lysosome_physiology3.17392972
6MP0006082_CNS_inflammation2.31109257
7MP0009046_muscle_twitch2.29157542
8MP0003635_abnormal_synaptic_transmissio2.26700559
9MP0003045_fibrosis2.26245122
10MP0002938_white_spotting2.18859893
11MP0003690_abnormal_glial_cell2.18680206
12MP0004858_abnormal_nervous_system2.17009998
13MP0005248_abnormal_Harderian_gland2.15522786
14MP0005171_absent_coat_pigmentation2.12676536
15MP0009278_abnormal_bone_marrow2.09573629
16MP0005076_abnormal_cell_differentiation2.07948132
17MP0002638_abnormal_pupillary_reflex2.07033840
18MP0008877_abnormal_DNA_methylation1.91793228
19MP0000778_abnormal_nervous_system1.90067557
20MP0003300_gastrointestinal_ulcer1.89141807
21MP0005058_abnormal_lysosome_morphology1.84049874
22MP0002064_seizures1.83519505
23MP0004510_myositis1.77466537
24MP0003191_abnormal_cellular_cholesterol1.73319837
25MP0003195_calcinosis1.68544698
26MP0002063_abnormal_learning/memory/cond1.66785479
27MP0003121_genomic_imprinting1.65985619
28MP0004742_abnormal_vestibular_system1.65493815
29MP0005167_abnormal_blood-brain_barrier1.64394083
30MP0003787_abnormal_imprinting1.63288384
31MP0008057_abnormal_DNA_replication1.60887415
32MP0002272_abnormal_nervous_system1.60788692
33MP0005394_taste/olfaction_phenotype1.58540957
34MP0005499_abnormal_olfactory_system1.58540957
35MP0003385_abnormal_body_wall1.57691214
36MP0003091_abnormal_cell_migration1.53076119
37MP0002009_preneoplasia1.50368083
38MP0009745_abnormal_behavioral_response1.47845391
39MP0001986_abnormal_taste_sensitivity1.46903677
40MP0006054_spinal_hemorrhage1.44866738
41MP0003890_abnormal_embryonic-extraembry1.39177994
42MP0003075_altered_response_to1.38207413
43MP0005623_abnormal_meninges_morphology1.36099733
44MP0005464_abnormal_platelet_physiology1.35308732
45MP0004270_analgesia1.34366949
46MP0004811_abnormal_neuron_physiology1.33740595
47MP0005551_abnormal_eye_electrophysiolog1.31914638
48MP0001851_eye_inflammation1.31852405
49MP0000015_abnormal_ear_pigmentation1.30916642
50MP0001485_abnormal_pinna_reflex1.30676809
51MP0002102_abnormal_ear_morphology1.30260923
52MP0008569_lethality_at_weaning1.30159636
53MP0003634_abnormal_glial_cell1.30072757
54MP0001177_atelectasis1.29901546
55MP0003755_abnormal_palate_morphology1.28708043
56MP0001486_abnormal_startle_reflex1.27724171
57MP0005671_abnormal_response_to1.26317495
58MP0002557_abnormal_social/conspecific_i1.26195015
59MP0002572_abnormal_emotion/affect_behav1.25554464
60MP0002419_abnormal_innate_immunity1.25088238
61MP0002998_abnormal_bone_remodeling1.24582707
62MP0002067_abnormal_sensory_capabilities1.24236036
63MP0001968_abnormal_touch/_nociception1.24206059
64MP0000428_abnormal_craniofacial_morphol1.24070995
65MP0008789_abnormal_olfactory_epithelium1.23807923
66MP0003122_maternal_imprinting1.22480893
67MP0003633_abnormal_nervous_system1.21268792
68MP0002736_abnormal_nociception_after1.18217543
69MP0003136_yellow_coat_color1.17439699
70MP0002184_abnormal_innervation1.16416303
71MP0003183_abnormal_peptide_metabolism1.14873516
72MP0005187_abnormal_penis_morphology1.14356012
73MP0002928_abnormal_bile_duct1.14056576
74MP0000733_abnormal_muscle_development1.14036448
75MP0000383_abnormal_hair_follicle1.13974864
76MP0003935_abnormal_craniofacial_develop1.12532255
77MP0003705_abnormal_hypodermis_morpholog1.10630566
78MP0003938_abnormal_ear_development1.10603934
79MP0003279_aneurysm1.08914350
80MP0002233_abnormal_nose_morphology1.08278482
81MP0000516_abnormal_urinary_system1.08109398
82MP0005367_renal/urinary_system_phenotyp1.08109398
83MP0001915_intracranial_hemorrhage1.07765702
84MP0003566_abnormal_cell_adhesion1.07747722
85MP0004924_abnormal_behavior1.06707052
86MP0005386_behavior/neurological_phenoty1.06707052
87MP0005423_abnormal_somatic_nervous1.05976901
88MP0000372_irregular_coat_pigmentation1.05608477
89MP0000920_abnormal_myelination1.05504759
90MP0000955_abnormal_spinal_cord1.05366541
91MP0010678_abnormal_skin_adnexa1.04137148
92MP0001299_abnormal_eye_distance/1.03485097
93MP0002735_abnormal_chemical_nociception1.02850905
94MP0002090_abnormal_vision1.01812747
95MP0002396_abnormal_hematopoietic_system1.01724109
96MP0004133_heterotaxia1.00665409
97MP0000371_diluted_coat_color0.99133212
98MP0002152_abnormal_brain_morphology0.97359124
99MP0001502_abnormal_circadian_rhythm0.97290942
100MP0001984_abnormal_olfaction0.97202507
101MP0003632_abnormal_nervous_system0.96955595
102MP0005253_abnormal_eye_physiology0.95557256
103MP0000432_abnormal_head_morphology0.95130446
104MP0003631_nervous_system_phenotype0.94899928
105MP0001835_abnormal_antigen_presentation0.93869215
106MP0000647_abnormal_sebaceous_gland0.93559842
107MP0001440_abnormal_grooming_behavior0.93398341
108MP0005174_abnormal_tail_pigmentation0.92908394
109MP0003937_abnormal_limbs/digits/tail_de0.92268285
110MP0002733_abnormal_thermal_nociception0.92030540
111MP0005166_decreased_susceptibility_to0.91114519
112MP0004185_abnormal_adipocyte_glucose0.91109996
113MP0009053_abnormal_anal_canal0.90599579
114MP0002653_abnormal_ependyma_morphology0.90303511
115MP0004883_abnormal_blood_vessel0.89837682
116MP0010307_abnormal_tumor_latency0.89646064
117MP0002734_abnormal_mechanical_nocicepti0.89381699
118MP0009780_abnormal_chondrocyte_physiolo0.88617646
119MP0003119_abnormal_digestive_system0.87788082
120MP0002452_abnormal_antigen_presenting0.87771453
121MP0002751_abnormal_autonomic_nervous0.87178550
122MP0002882_abnormal_neuron_morphology0.86519274
123MP0000631_abnormal_neuroendocrine_gland0.86465277
124MP0000767_abnormal_smooth_muscle0.86089440
125MP0008961_abnormal_basal_metabolism0.86049446
126MP0001970_abnormal_pain_threshold0.85473707
127MP0001533_abnormal_skeleton_physiology0.85334251
128MP0004145_abnormal_muscle_electrophysio0.84716946
129MP0001849_ear_inflammation0.84563314
130MP0010030_abnormal_orbit_morphology0.84201863
131MP0003828_pulmonary_edema0.83581310
132MP0003448_altered_tumor_morphology0.82489790
133MP0009250_abnormal_appendicular_skeleto0.82042620
134MP0001324_abnormal_eye_pigmentation0.81674690
135MP0002168_other_aberrant_phenotype0.80966776
136MP0005257_abnormal_intraocular_pressure0.80417079
137MP0000427_abnormal_hair_cycle0.79782571
138MP0009703_decreased_birth_body0.78527139
139MP0005646_abnormal_pituitary_gland0.77213179
140MP0006072_abnormal_retinal_apoptosis0.76645839
141MP0002925_abnormal_cardiovascular_devel0.74917908
142MP0003861_abnormal_nervous_system0.72689091
143MP0004808_abnormal_hematopoietic_stem0.72358212
144MP0004484_altered_response_of0.71161021
145MP0001501_abnormal_sleep_pattern0.70807959
146MP0002723_abnormal_immune_serum0.70738865
147MP0000604_amyloidosis0.70709216
148MP0004130_abnormal_muscle_cell0.70365791
149MP0004885_abnormal_endolymph0.69151614
150MP0002066_abnormal_motor_capabilities/c0.68450179
151MP0008874_decreased_physiological_sensi0.67353288
152MP0001819_abnormal_immune_cell0.65593455
153MP0001800_abnormal_humoral_immune0.65397307
154MP0003880_abnormal_central_pattern0.64539377
155MP0000534_abnormal_ureter_morphology0.63817002
156MP0005197_abnormal_uvea_morphology0.63433073
157MP0005409_darkened_coat_color0.63414836
158MP0001958_emphysema0.63324867
159MP0005670_abnormal_white_adipose0.62864675

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)4.07685569
2Mutism (HP:0002300)4.06118681
3Arterial tortuosity (HP:0005116)3.87239052
4Systemic lupus erythematosus (HP:0002725)3.84689063
5Urethral obstruction (HP:0000796)3.66003318
6Vascular tortuosity (HP:0004948)3.43263856
7Disinhibition (HP:0000734)3.23725052
8Hyperventilation (HP:0002883)3.16119652
9Abnormality of liposaccharide metabolism (HP:0010968)3.13559378
10Abnormality of glycosphingolipid metabolism (HP:0004343)3.13559378
11Abnormality of glycolipid metabolism (HP:0010969)3.13559378
12Action tremor (HP:0002345)3.00848056
13Atonic seizures (HP:0010819)2.98229933
14Glomerulonephritis (HP:0000099)2.96022734
15Volvulus (HP:0002580)2.79461696
16Inappropriate behavior (HP:0000719)2.77806882
17Aortic aneurysm (HP:0004942)2.76973775
18Intestinal atresia (HP:0011100)2.72215093
19Difficulty running (HP:0009046)2.68947399
20Absent speech (HP:0001344)2.66209652
21Neuronal loss in central nervous system (HP:0002529)2.64933227
22Increased cerebral lipofuscin (HP:0011813)2.57195501
23Thickened helices (HP:0000391)2.56390437
24Shallow orbits (HP:0000586)2.55408591
25Disproportionate tall stature (HP:0001519)2.55197307
26Abnormality of binocular vision (HP:0011514)2.50445695
27Diplopia (HP:0000651)2.50445695
28Genetic anticipation (HP:0003743)2.49727810
29Progressive cerebellar ataxia (HP:0002073)2.45703025
30Hematochezia (HP:0002573)2.45447638
31Arnold-Chiari malformation (HP:0002308)2.45404954
32Aplasia/Hypoplasia of the fovea (HP:0008060)2.41207735
33Hypoplasia of the fovea (HP:0007750)2.41207735
34Hemiplegia (HP:0002301)2.40485174
35Retinal atrophy (HP:0001105)2.35534988
36Tented upper lip vermilion (HP:0010804)2.32707954
37Supranuclear gaze palsy (HP:0000605)2.26682913
38Abnormality of the ischium (HP:0003174)2.23855599
39Exotropia (HP:0000577)2.23205145
40Striae distensae (HP:0001065)2.22624426
41Mitral valve prolapse (HP:0001634)2.19426974
42Obstructive sleep apnea (HP:0002870)2.18864584
43Focal seizures (HP:0007359)2.17375434
44Shawl scrotum (HP:0000049)2.16290221
45Recurrent abscess formation (HP:0002722)2.14868559
46Hyperacusis (HP:0010780)2.13655036
47Excessive salivation (HP:0003781)2.12121352
48Drooling (HP:0002307)2.12121352
49Abnormality of chromosome segregation (HP:0002916)2.09153769
50Apathy (HP:0000741)2.08856992
51Urinary bladder sphincter dysfunction (HP:0002839)2.05744875
52Increased neuronal autofluorescent lipopigment (HP:0002074)2.03840334
53Neoplasm of the adrenal cortex (HP:0100641)2.03441172
54Recurrent bacterial skin infections (HP:0005406)2.02534132
55Spinal muscular atrophy (HP:0007269)2.02136552
56Neoplasm of the oral cavity (HP:0100649)2.02109156
57Aortic dissection (HP:0002647)2.01782448
58Abnormality of the fovea (HP:0000493)1.98945571
59Macroorchidism (HP:0000053)1.98680229
60Postural instability (HP:0002172)1.96802262
61Glioma (HP:0009733)1.96556179
62Aqueductal stenosis (HP:0002410)1.95818579
63Lower limb asymmetry (HP:0100559)1.95786387
64Pointed chin (HP:0000307)1.95296088
65Hemiparesis (HP:0001269)1.94914009
66Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.94494188
67Preaxial foot polydactyly (HP:0001841)1.93884976
68Optic nerve hypoplasia (HP:0000609)1.92081499
69Narrow palate (HP:0000189)1.90871447
70Hepatoblastoma (HP:0002884)1.90514818
71Generalized tonic-clonic seizures (HP:0002069)1.89449396
72Absent frontal sinuses (HP:0002688)1.87345939
73Abnormality of the aortic arch (HP:0012303)1.86478254
74Broad-based gait (HP:0002136)1.86127789
75Lower limb amyotrophy (HP:0007210)1.84585717
76Oligodactyly (hands) (HP:0001180)1.84354169
77Aplasia/Hypoplasia of the uvula (HP:0010293)1.84248523
78Dialeptic seizures (HP:0011146)1.83259763
79Elfin facies (HP:0004428)1.80684180
80Leiomyosarcoma (HP:0100243)1.78769069
81Uterine leiomyosarcoma (HP:0002891)1.78769069
82Diminished motivation (HP:0000745)1.78438982
83Ectopic kidney (HP:0000086)1.77898611
84Midline defect of the nose (HP:0004122)1.76744865
85Intellectual disability, moderate (HP:0002342)1.76665881
86Abnormality of the nasal septum (HP:0000419)1.75149081
87Transitional cell carcinoma of the bladder (HP:0006740)1.74902696
88Abnormality of chromosome stability (HP:0003220)1.74661612
89Limb dystonia (HP:0002451)1.74581006
90Small hand (HP:0200055)1.74286179
91Epileptic encephalopathy (HP:0200134)1.72900541
92Gastroesophageal reflux (HP:0002020)1.71998963
93Eczematoid dermatitis (HP:0000976)1.71041151
94Hypoplastic ischia (HP:0003175)1.71033448
95Clubbing of toes (HP:0100760)1.70727410
96Complement deficiency (HP:0004431)1.70701829
97Heterotopia (HP:0002282)1.70358314
98Visual hallucinations (HP:0002367)1.69637376
99Trigonocephaly (HP:0000243)1.69087766
100Astrocytoma (HP:0009592)1.69005111
101Abnormality of the astrocytes (HP:0100707)1.69005111
102Bilateral sensorineural hearing impairment (HP:0008619)1.68890411
103Dysostosis multiplex (HP:0000943)1.67430648
104Dilatation of the ascending aorta (HP:0005111)1.67288785
105Febrile seizures (HP:0002373)1.65858363
106Blue irides (HP:0000635)1.65855226
107Megalencephaly (HP:0001355)1.64371825
108Aneurysm (HP:0002617)1.64199055
109Truncal ataxia (HP:0002078)1.63764052
110Downturned corners of mouth (HP:0002714)1.63569171
111Nephritis (HP:0000123)1.63455713
112Abnormality of incisor morphology (HP:0011063)1.63415678
113Facial hemangioma (HP:0000329)1.62597132
114Mild short stature (HP:0003502)1.62517527
115Cortical dysplasia (HP:0002539)1.62344807
116Gaze-evoked nystagmus (HP:0000640)1.62039251
117Hand muscle atrophy (HP:0009130)1.61536117
118Aplasia/Hypoplasia of the macula (HP:0008059)1.61519954
119Papilledema (HP:0001085)1.61418624
120Bladder neoplasm (HP:0009725)1.60641744
121Bladder carcinoma (HP:0002862)1.60641744
122Decreased lacrimation (HP:0000633)1.60546358
123Obsessive-compulsive behavior (HP:0000722)1.60517307
124Gastrointestinal atresia (HP:0002589)1.60225772
125Colitis (HP:0002583)1.59482112
126Upper motor neuron abnormality (HP:0002127)1.59371832
127Truncal obesity (HP:0001956)1.58725282
128Abnormality of ocular smooth pursuit (HP:0000617)1.58574819
129Hamartoma (HP:0010566)1.58504135
130Scanning speech (HP:0002168)1.58130657
131Open mouth (HP:0000194)1.58036577
132Depression (HP:0000716)1.57264050
133Abnormality of the sella turcica (HP:0002679)1.56114191
134Protruding tongue (HP:0010808)1.56078190
135Short 4th metacarpal (HP:0010044)1.55732771
136Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.55732771
137Impaired smooth pursuit (HP:0007772)1.55355040
138Absence seizures (HP:0002121)1.55202001
139Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.54216533
140Aplasia/Hypoplasia of the sternum (HP:0006714)1.53672161
141Focal motor seizures (HP:0011153)1.53610506
142Insidious onset (HP:0003587)1.53562096
143Termporal pattern (HP:0011008)1.53562096
144Stereotypic behavior (HP:0000733)1.53401275
145Ependymoma (HP:0002888)1.53102909
146Anal stenosis (HP:0002025)1.52854877
147Renovascular hypertension (HP:0100817)1.52496681
148Abnormality of the labia minora (HP:0012880)1.52237334
149Agitation (HP:0000713)1.51882873
150Embryonal renal neoplasm (HP:0011794)1.51493351
151Bowel incontinence (HP:0002607)1.51212599
152Oligodontia (HP:0000677)1.50655617
153Ulnar claw (HP:0001178)1.49772952
154Cutaneous finger syndactyly (HP:0010554)1.49563853
155Tapered finger (HP:0001182)1.49381761
156Cupped ear (HP:0000378)1.48997875
157Laryngomalacia (HP:0001601)1.48311833
158Increased CSF protein (HP:0002922)1.47205795
159Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.46746544
160Axonal loss (HP:0003447)1.46744274
161Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.46618247
162Vitreoretinal degeneration (HP:0000655)1.46616626
163Upper limb amyotrophy (HP:0009129)1.45543484
164Distal upper limb amyotrophy (HP:0007149)1.45543484

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR24.89651888
2FRK3.91580717
3WEE13.21317931
4CAMK1G3.08688450
5MAP3K92.93653321
6MARK12.91941837
7BMPR1B2.82700593
8CAMK1D2.78601641
9CASK2.64276002
10SIK22.60450700
11RIPK42.45921209
12MKNK22.27231559
13TRIM282.24373035
14WNK31.98096253
15AKT31.90515513
16CCNB11.88830716
17GRK71.86103408
18BRSK21.82985228
19CSF1R1.75365335
20MAP3K41.70409007
21FGFR21.67353211
22NTRK21.67297536
23RIPK11.65966035
24EPHA41.65855690
25ACVR1B1.63343026
26EEF2K1.62833208
27ICK1.60985240
28CAMKK11.57560197
29MAPK151.54866332
30PRKD31.51811553
31CAMKK21.51477828
32CDK121.45661180
33NTRK31.40699659
34UHMK11.39172701
35PAK61.38491415
36MINK11.32658672
37FES1.26065983
38MKNK11.22608531
39DAPK21.21297112
40SIK31.18112551
41HCK1.15717319
42JAK11.13565756
43MAP3K131.11734059
44CAMK41.10312142
45MAPK121.07028427
46MAP3K61.05743779
47PAK41.05660246
48TYK21.02174006
49RET1.01134977
50PTK61.00931915
51SGK2230.97733207
52SGK4940.97733207
53MAP2K40.97227628
54LATS20.97038706
55DMPK0.97035137
56PINK10.96251647
57PKN20.92332108
58CDK30.91795545
59BRSK10.91654598
60CDK60.90809874
61EPHB20.90631623
62MARK20.89984478
63YES10.89838118
64PAK30.89358154
65STK110.88912390
66WNK10.88733724
67SGK30.88598597
68ALK0.86396815
69STK38L0.83060042
70STK380.81129762
71STK390.79163484
72ROCK10.78846370
73TYRO30.78528246
74KSR10.78508572
75MELK0.77863533
76LATS10.76271615
77ERBB20.75879775
78NEK20.75147375
79MAPK130.74832942
80PLK40.73829866
81FGR0.72288147
82CDK50.71900061
83PKN10.71033150
84PHKG10.69713291
85PHKG20.69713291
86PRKCH0.68256107
87CSNK1A1L0.67969468
88NUAK10.65330861
89PNCK0.64876342
90PLK20.64832846
91TGFBR10.64350700
92FYN0.63822671
93SGK20.63580446
94STK30.63214165
95ERBB30.62396516
96MTOR0.62380749
97PDGFRB0.60463791
98MAPK70.60136167
99BCR0.60111572
100CAMK10.59977048
101RAF10.59910060
102MAP3K100.59842363
103PAK20.59828210
104ITK0.59803254
105TIE10.58846110
106CLK10.58579085
107EGFR0.58298153
108SGK10.56231051
109BLK0.54639451
110NEK60.54392160
111MAP3K140.53538958
112EPHB10.52844892
113PLK30.52832457
114FER0.52701537
115MOS0.51997692
116BRD40.51991909
117CDC42BPA0.51748105
118PRKCG0.51424359
119HIPK20.50884827
120CSK0.50410408
121PDK10.50390004
122TRIB30.50163686
123PRKCZ0.49635708
124PDGFRA0.49564654
125GRK50.49542574
126SRC0.49521466
127STK100.48858005
128MAP3K70.48625261
129FGFR30.48576418
130MAP2K30.48113467
131JAK20.47146930
132MAPK100.46393322
133NTRK10.46310669
134EIF2AK20.45497737
135RPS6KA20.45037809
136IGF1R0.44781250
137OXSR10.44365364
138SCYL20.43140034
139MAPK80.42712194
140CSNK1G10.42698857
141PTK2B0.42689596
142BMX0.41702290
143CDK150.41669732
144TNIK0.40221106
145CSNK1G20.39861380
146CDK180.39696234
147ROCK20.39401103
148IRAK20.35889940
149PRKAA10.35297040
150MARK30.35075976
151PRKG10.34163921
152CAMK2A0.32604005
153GSK3B0.32565454

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043801.68974521
2Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.51535309
3Staphylococcus aureus infection_Homo sapiens_hsa051501.51515596
4Glycosaminoglycan degradation_Homo sapiens_hsa005311.50068852
5Oocyte meiosis_Homo sapiens_hsa041141.47230846
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.46942109
7Nicotine addiction_Homo sapiens_hsa050331.41315645
8Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.40753265
9Insulin secretion_Homo sapiens_hsa049111.40333020
10Type II diabetes mellitus_Homo sapiens_hsa049301.35306391
11B cell receptor signaling pathway_Homo sapiens_hsa046621.34381494
12Melanogenesis_Homo sapiens_hsa049161.29004835
13Glutamatergic synapse_Homo sapiens_hsa047241.28107665
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25012144
15Chronic myeloid leukemia_Homo sapiens_hsa052201.24776343
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22148866
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21760327
18Long-term potentiation_Homo sapiens_hsa047201.21471229
19Colorectal cancer_Homo sapiens_hsa052101.21439833
20Olfactory transduction_Homo sapiens_hsa047401.21192124
21Neurotrophin signaling pathway_Homo sapiens_hsa047221.20849014
22Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19865863
23Morphine addiction_Homo sapiens_hsa050321.19700989
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.19646979
25Glioma_Homo sapiens_hsa052141.19261758
26Fanconi anemia pathway_Homo sapiens_hsa034601.19117036
27Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18886540
28Circadian entrainment_Homo sapiens_hsa047131.17994766
29Leishmaniasis_Homo sapiens_hsa051401.16307620
30Pancreatic cancer_Homo sapiens_hsa052121.15710787
31Hippo signaling pathway_Homo sapiens_hsa043901.15636147
32Synaptic vesicle cycle_Homo sapiens_hsa047211.14142767
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12419193
34Circadian rhythm_Homo sapiens_hsa047101.12336816
35Estrogen signaling pathway_Homo sapiens_hsa049151.12299750
36Hedgehog signaling pathway_Homo sapiens_hsa043401.11716303
37Salivary secretion_Homo sapiens_hsa049701.11539606
38Dorso-ventral axis formation_Homo sapiens_hsa043201.10186229
39Oxytocin signaling pathway_Homo sapiens_hsa049211.09844197
40GnRH signaling pathway_Homo sapiens_hsa049121.09822096
41Taste transduction_Homo sapiens_hsa047421.09805509
42Pertussis_Homo sapiens_hsa051331.09144995
43TGF-beta signaling pathway_Homo sapiens_hsa043501.08914259
44Chemokine signaling pathway_Homo sapiens_hsa040621.07566775
45Renin secretion_Homo sapiens_hsa049241.07397329
46* Axon guidance_Homo sapiens_hsa043601.06838818
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06079486
48Long-term depression_Homo sapiens_hsa047301.05196431
49Wnt signaling pathway_Homo sapiens_hsa043101.05148162
50Cholinergic synapse_Homo sapiens_hsa047251.02998899
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02931489
52Aldosterone synthesis and secretion_Homo sapiens_hsa049251.02643731
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00950572
54GABAergic synapse_Homo sapiens_hsa047271.00936620
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99801277
56ErbB signaling pathway_Homo sapiens_hsa040120.99676535
57Renal cell carcinoma_Homo sapiens_hsa052110.99675704
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98665751
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.97505048
60Rap1 signaling pathway_Homo sapiens_hsa040150.97456445
61Notch signaling pathway_Homo sapiens_hsa043300.95479357
62Adherens junction_Homo sapiens_hsa045200.95168656
63Lysosome_Homo sapiens_hsa041420.94706673
64Lysine degradation_Homo sapiens_hsa003100.94679341
65Tuberculosis_Homo sapiens_hsa051520.94569305
66Platelet activation_Homo sapiens_hsa046110.94415814
67Gastric acid secretion_Homo sapiens_hsa049710.94107220
68Basal cell carcinoma_Homo sapiens_hsa052170.94078876
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93198268
70MAPK signaling pathway_Homo sapiens_hsa040100.93015693
71Serotonergic synapse_Homo sapiens_hsa047260.92768668
72Endometrial cancer_Homo sapiens_hsa052130.92709518
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92185829
74Toxoplasmosis_Homo sapiens_hsa051450.91993677
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91960225
76mTOR signaling pathway_Homo sapiens_hsa041500.90528948
77Dopaminergic synapse_Homo sapiens_hsa047280.90267654
78VEGF signaling pathway_Homo sapiens_hsa043700.89839741
79Endocytosis_Homo sapiens_hsa041440.88784262
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88744115
81cAMP signaling pathway_Homo sapiens_hsa040240.86375584
82Cell cycle_Homo sapiens_hsa041100.86330275
83Gap junction_Homo sapiens_hsa045400.85140189
84Prion diseases_Homo sapiens_hsa050200.83272800
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83034494
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82367545
87Non-small cell lung cancer_Homo sapiens_hsa052230.81788653
88Other glycan degradation_Homo sapiens_hsa005110.81584069
89Dilated cardiomyopathy_Homo sapiens_hsa054140.81218951
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.81065766
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80867071
92Choline metabolism in cancer_Homo sapiens_hsa052310.80642978
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80271379
94Salmonella infection_Homo sapiens_hsa051320.79195949
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.78949396
96ABC transporters_Homo sapiens_hsa020100.78783343
97Influenza A_Homo sapiens_hsa051640.78571199
98Vitamin B6 metabolism_Homo sapiens_hsa007500.78408651
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78397196
100Phototransduction_Homo sapiens_hsa047440.78271994
101Proteoglycans in cancer_Homo sapiens_hsa052050.77705743
102Thyroid hormone synthesis_Homo sapiens_hsa049180.77615687
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77231876
104TNF signaling pathway_Homo sapiens_hsa046680.77133284
105Focal adhesion_Homo sapiens_hsa045100.76962517
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.76405792
107Calcium signaling pathway_Homo sapiens_hsa040200.76019765
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75364933
109T cell receptor signaling pathway_Homo sapiens_hsa046600.74746727
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74342033
111Viral myocarditis_Homo sapiens_hsa054160.74247001
112Melanoma_Homo sapiens_hsa052180.74026557
113Amphetamine addiction_Homo sapiens_hsa050310.73815734
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73459836
115Amoebiasis_Homo sapiens_hsa051460.72617245
116Inositol phosphate metabolism_Homo sapiens_hsa005620.72443882
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70990614
118MicroRNAs in cancer_Homo sapiens_hsa052060.69831814
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68064185
120Ras signaling pathway_Homo sapiens_hsa040140.67683878
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67311396
122Basal transcription factors_Homo sapiens_hsa030220.66970138
123Hepatitis B_Homo sapiens_hsa051610.66120296
124African trypanosomiasis_Homo sapiens_hsa051430.65659926
125Cocaine addiction_Homo sapiens_hsa050300.65470972
126FoxO signaling pathway_Homo sapiens_hsa040680.65213363
127Prostate cancer_Homo sapiens_hsa052150.63320163
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61088893
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54838143
130Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54683014
131Homologous recombination_Homo sapiens_hsa034400.49697532
132Non-homologous end-joining_Homo sapiens_hsa034500.49333525
133Pathways in cancer_Homo sapiens_hsa052000.48760462

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