SRGAP2D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.93912209
2nuclear pore organization (GO:0006999)4.80316852
3pore complex assembly (GO:0046931)4.50935305
4mitotic chromosome condensation (GO:0007076)4.33904664
5cell adhesion mediated by integrin (GO:0033627)4.15955235
6Golgi transport vesicle coating (GO:0048200)4.12200053
7COPI coating of Golgi vesicle (GO:0048205)4.12200053
8skin morphogenesis (GO:0043589)4.09328230
9cytoskeletal anchoring at plasma membrane (GO:0007016)4.07308559
10regulation of RNA export from nucleus (GO:0046831)3.98793951
11DNA unwinding involved in DNA replication (GO:0006268)3.79102473
12sister chromatid segregation (GO:0000819)3.74397972
13mitotic sister chromatid segregation (GO:0000070)3.73775045
14protein localization to endosome (GO:0036010)3.67870740
15cell-substrate junction assembly (GO:0007044)3.65508044
16regulation of nucleobase-containing compound transport (GO:0032239)3.65484756
17hemidesmosome assembly (GO:0031581)3.62491292
18cortical actin cytoskeleton organization (GO:0030866)3.43321299
19regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.26615264
20cell-substrate adherens junction assembly (GO:0007045)3.21589106
21focal adhesion assembly (GO:0048041)3.21589106
22regulation of mitotic spindle organization (GO:0060236)3.21431841
23cortical cytoskeleton organization (GO:0030865)3.11808363
24adherens junction assembly (GO:0034333)3.10678582
25activation of Rac GTPase activity (GO:0032863)3.09235410
26nuclear envelope disassembly (GO:0051081)3.03185884
27membrane disassembly (GO:0030397)3.03185884
28mitotic nuclear envelope disassembly (GO:0007077)3.01070068
29pinocytosis (GO:0006907)3.00594093
30mitotic sister chromatid cohesion (GO:0007064)2.96898118
31wound healing, spreading of epidermal cells (GO:0035313)2.89272376
32negative regulation of anoikis (GO:2000811)2.88247043
33regulation of early endosome to late endosome transport (GO:2000641)2.84817477
34basement membrane organization (GO:0071711)2.83794906
35mitotic cytokinesis (GO:0000281)2.83260275
36cellular protein complex localization (GO:0034629)2.80496374
37spliceosomal tri-snRNP complex assembly (GO:0000244)2.79798067
38regulation of translational fidelity (GO:0006450)2.78782824
39mitotic metaphase plate congression (GO:0007080)2.77941397
40negative regulation of fatty acid transport (GO:2000192)2.77628044
41embryonic process involved in female pregnancy (GO:0060136)2.77610450
42hypotonic response (GO:0006971)2.77339865
43regulation of NFAT protein import into nucleus (GO:0051532)2.76576011
44regulation of histone H3-K27 methylation (GO:0061085)2.74244489
45positive regulation of blood vessel endothelial cell migration (GO:0043536)2.74241605
46protein export from nucleus (GO:0006611)2.72608336
47glucocorticoid receptor signaling pathway (GO:0042921)2.71917188
48protein localization to chromosome, centromeric region (GO:0071459)2.70607104
49positive regulation of DNA-dependent DNA replication (GO:2000105)2.69623527
50chromosome condensation (GO:0030261)2.69069320
51endodermal cell differentiation (GO:0035987)2.67078237
52cellular response to epidermal growth factor stimulus (GO:0071364)2.66684253
53retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.66630974
54establishment of spindle localization (GO:0051293)2.65968762
55mesodermal cell differentiation (GO:0048333)2.63979909
56negative regulation of fibroblast apoptotic process (GO:2000270)2.63823028
57regulation of spindle organization (GO:0090224)2.63589968
58nuclear envelope organization (GO:0006998)2.62755344
59vesicle coating (GO:0006901)2.62017706
60activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.60430267
61membrane protein ectodomain proteolysis (GO:0006509)2.58242526
62chondrocyte proliferation (GO:0035988)2.57790879
63regulation of sister chromatid cohesion (GO:0007063)2.56471904
64peptidyl-lysine dimethylation (GO:0018027)2.55742526
65COPII vesicle coating (GO:0048208)2.55565994
66cytoskeleton-dependent cytokinesis (GO:0061640)2.55564727
67positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.55504420
68retina vasculature morphogenesis in camera-type eye (GO:0061299)2.54912912
69positive regulation of nuclease activity (GO:0032075)2.54399475
70response to epidermal growth factor (GO:0070849)2.53969536
71hepatocyte differentiation (GO:0070365)2.52423456
72establishment of spindle orientation (GO:0051294)2.51211074
73corticosteroid receptor signaling pathway (GO:0031958)2.50619925
74regulation of anoikis (GO:2000209)2.49830693
75regulation of mammary gland epithelial cell proliferation (GO:0033599)2.49344512
76response to laminar fluid shear stress (GO:0034616)2.48175688
77histone phosphorylation (GO:0016572)2.47633841
78establishment of mitotic spindle localization (GO:0040001)2.46238822
79endoplasmic reticulum unfolded protein response (GO:0030968)2.45388001
80mammary gland epithelial cell proliferation (GO:0033598)2.45123657
81DNA duplex unwinding (GO:0032508)2.44210931
82DNA topological change (GO:0006265)2.43270729
83regulation of translational termination (GO:0006449)2.42901814
84negative regulation of DNA repair (GO:0045738)2.42543305
85wound healing, spreading of cells (GO:0044319)2.42133616
86iron ion import (GO:0097286)2.41404158
87positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.40855669
88positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.39876086
89epithelial cell-cell adhesion (GO:0090136)2.38819963
90maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.37923695
91ER-nucleus signaling pathway (GO:0006984)2.37261045
92regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.36606594
93collagen fibril organization (GO:0030199)2.35491614
94positive regulation of osteoblast proliferation (GO:0033690)2.35298606
95apoptotic cell clearance (GO:0043277)2.34592707
96protein localization to microtubule (GO:0035372)2.33904350
97DNA packaging (GO:0006323)2.33175435
98stress fiber assembly (GO:0043149)2.32641704
99peptidyl-threonine modification (GO:0018210)2.32459484
100metaphase plate congression (GO:0051310)2.32390042

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.75610179
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.73966290
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.17518398
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.03955145
5EGR1_19374776_ChIP-ChIP_THP-1_Human4.00954580
6AR_21909140_ChIP-Seq_LNCAP_Human2.66905852
7ZNF263_19887448_ChIP-Seq_K562_Human2.32000038
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.10300807
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08976989
10ELK3_25401928_ChIP-Seq_HUVEC_Human2.08897134
11CLOCK_20551151_ChIP-Seq_293T_Human2.05136761
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.00698747
13RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.00615056
14P300_27058665_Chip-Seq_ZR-75-30cells_Human1.99093135
15MYC_22102868_ChIP-Seq_BL_Human1.98051460
16KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.96556131
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.90056901
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.89574587
19MYB_21317192_ChIP-Seq_ERMYB_Mouse1.84055511
20WT1_19549856_ChIP-ChIP_CCG9911_Human1.79925710
21SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.78986531
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.78831173
23UBF1/2_26484160_Chip-Seq_HMECs_Human1.77484232
24CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.76381406
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.70617337
26CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.69868911
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.69813406
28SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.68437346
29SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.68437346
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.67688446
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65907955
32KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.65229273
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.60336141
34TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58221217
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.55942074
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.55061264
37VDR_21846776_ChIP-Seq_THP-1_Human1.50989273
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49975467
39SOX9_24532713_ChIP-Seq_HFSC_Mouse1.48030959
40TCF7_22412390_ChIP-Seq_EML_Mouse1.46814986
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.46407171
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44669092
43ATF3_27146783_Chip-Seq_COLON_Human1.43089517
44CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.42550769
45NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.40579607
46KDM2B_26808549_Chip-Seq_K562_Human1.39521372
47PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.39203507
48E2F4_17652178_ChIP-ChIP_JURKAT_Human1.38978535
49RACK7_27058665_Chip-Seq_MCF-7_Human1.38450797
50HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.38159125
51TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.38055894
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37269188
53BRD4_25478319_ChIP-Seq_HGPS_Human1.36886092
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.36484672
55TP53_22127205_ChIP-Seq_IMR90_Human1.34048168
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32814094
57TFEB_21752829_ChIP-Seq_HELA_Human1.31103270
58DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.30679560
59ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.29631374
60EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29295036
61TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26310854
62SALL4_18804426_ChIP-ChIP_XEN_Mouse1.23478191
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.23313309
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.20466733
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19091426
66PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18778738
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17193457
68SMAD_19615063_ChIP-ChIP_OVARY_Human1.17063625
69ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14501052
70EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14286419
71UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14262807
72GATA2_21666600_ChIP-Seq_HMVEC_Human1.13047535
73GATA1_19941826_ChIP-Seq_K562_Human1.12963851
74KDM2B_26808549_Chip-Seq_DND41_Human1.12829615
75MYCN_18555785_ChIP-Seq_MESCs_Mouse1.12407746
76TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11527156
77NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.11524691
78KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09673789
79KDM2B_26808549_Chip-Seq_JURKAT_Human1.08558404
80TBX20_22080862_ChIP-Seq_HEART_Mouse1.08371819
81TBX20_22328084_ChIP-Seq_HEART_Mouse1.08371819
82ESR2_21235772_ChIP-Seq_MCF-7_Human1.07936635
83CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06890821
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06211961
85NCOR1_26117541_ChIP-Seq_K562_Human1.06149097
86EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.05374801
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04836411
88FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.04564936
89NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04318052
90MYC_18555785_ChIP-Seq_MESCs_Mouse1.03435398
91SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03419034
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02169997
93RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00875718
94ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99623462
95NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99183034
96GATA1_19941827_ChIP-Seq_MEL_Mouse0.98677036
97KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98486783
98CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98030243
99CHD1_26751641_Chip-Seq_LNCaP_Human0.97900087
100SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97472288

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.81046906
2MP0008438_abnormal_cutaneous_collagen4.39316587
3MP0002877_abnormal_melanocyte_morpholog3.19363412
4MP0003566_abnormal_cell_adhesion3.17500126
5MP0005451_abnormal_body_composition3.01430726
6MP0010352_gastrointestinal_tract_polyps2.89261238
7MP0005257_abnormal_intraocular_pressure2.81359432
8MP0005623_abnormal_meninges_morphology2.69508994
9MP0005076_abnormal_cell_differentiation2.65942552
10MP0003091_abnormal_cell_migration2.54748309
11MP0005171_absent_coat_pigmentation2.44747991
12MP0003950_abnormal_plasma_membrane2.29654462
13MP0004233_abnormal_muscle_weight2.19532950
14MP0003656_abnormal_erythrocyte_physiolo1.95183265
15MP0004272_abnormal_basement_membrane1.93372601
16MP0003111_abnormal_nucleus_morphology1.82023220
17MP0001849_ear_inflammation1.79909875
18MP0005023_abnormal_wound_healing1.71322860
19MP0000733_abnormal_muscle_development1.70393636
20MP0002060_abnormal_skin_morphology1.69313027
21MP0001915_intracranial_hemorrhage1.63703416
22MP0010307_abnormal_tumor_latency1.62876219
23MP0003191_abnormal_cellular_cholesterol1.57145955
24MP0005058_abnormal_lysosome_morphology1.54449558
25MP0006054_spinal_hemorrhage1.48997226
26MP0008057_abnormal_DNA_replication1.47302725
27MP0010368_abnormal_lymphatic_system1.43910330
28MP0003453_abnormal_keratinocyte_physiol1.43492857
29MP0009840_abnormal_foam_cell1.42443095
30MP0003077_abnormal_cell_cycle1.41518268
31MP0004808_abnormal_hematopoietic_stem1.40282595
32MP0001348_abnormal_lacrimal_gland1.39389200
33MP0005275_abnormal_skin_tensile1.38087975
34MP0001958_emphysema1.36355031
35MP0003300_gastrointestinal_ulcer1.34894170
36MP0005621_abnormal_cell_physiology1.34060811
37MP0010094_abnormal_chromosome_stability1.29254194
38MP0008007_abnormal_cellular_replicative1.28730894
39MP0001730_embryonic_growth_arrest1.28248395
40MP0000350_abnormal_cell_proliferation1.27010189
41MP0004185_abnormal_adipocyte_glucose1.25846476
42MP0002089_abnormal_postnatal_growth/wei1.20708580
43MP0000767_abnormal_smooth_muscle1.19333782
44MP0002896_abnormal_bone_mineralization1.17795720
45MP0008932_abnormal_embryonic_tissue1.17355483
46MP0000003_abnormal_adipose_tissue1.16356462
47MP0005409_darkened_coat_color1.16244046
48MP0003941_abnormal_skin_development1.15915807
49MP0003279_aneurysm1.15281891
50MP0003984_embryonic_growth_retardation1.10973998
51MP0002086_abnormal_extraembryonic_tissu1.09777028
52MP0000751_myopathy1.09198986
53MP0005380_embryogenesis_phenotype1.07619306
54MP0001672_abnormal_embryogenesis/_devel1.07619306
55MP0008260_abnormal_autophagy1.06836869
56MP0000747_muscle_weakness1.04785613
57MP0002396_abnormal_hematopoietic_system1.04273268
58MP0003385_abnormal_body_wall1.03330828
59MP0004957_abnormal_blastocyst_morpholog1.03232342
60MP0002088_abnormal_embryonic_growth/wei1.03168130
61MP0001661_extended_life_span1.02935684
62MP0000428_abnormal_craniofacial_morphol1.02892162
63MP0002080_prenatal_lethality1.02222269
64MP0003136_yellow_coat_color1.00329587
65MP0008004_abnormal_stomach_pH0.99682191
66MP0003115_abnormal_respiratory_system0.97967958
67MP0005083_abnormal_biliary_tract0.96604970
68MP0000759_abnormal_skeletal_muscle0.96213958
69MP0005384_cellular_phenotype0.96137908
70MP0001299_abnormal_eye_distance/0.95704188
71MP0000371_diluted_coat_color0.95379209
72MP0001243_abnormal_dermal_layer0.93331318
73MP0002269_muscular_atrophy0.90518266
74MP0003172_abnormal_lysosome_physiology0.90051584
75MP0004087_abnormal_muscle_fiber0.90033249
76MP0002697_abnormal_eye_size0.87547269
77MP0002092_abnormal_eye_morphology0.87359470
78MP0010630_abnormal_cardiac_muscle0.86219258
79MP0001697_abnormal_embryo_size0.85457319
80MP0000762_abnormal_tongue_morphology0.85308007
81MP0010234_abnormal_vibrissa_follicle0.85104176
82MP0003303_peritoneal_inflammation0.85036886
83MP0009278_abnormal_bone_marrow0.84516725
84MP0002075_abnormal_coat/hair_pigmentati0.84226972
85MP0005408_hypopigmentation0.83623738
86MP0002084_abnormal_developmental_patter0.82770375
87MP0002332_abnormal_exercise_endurance0.82418294
88MP0000749_muscle_degeneration0.79361021
89MP0000432_abnormal_head_morphology0.77057335
90MP0004947_skin_inflammation0.76850668
91MP0000858_altered_metastatic_potential0.76093136
92MP0004197_abnormal_fetal_growth/weight/0.75645709
93MP0000569_abnormal_digit_pigmentation0.74645190
94MP0001186_pigmentation_phenotype0.74325087
95MP0000013_abnormal_adipose_tissue0.73879854
96MP0003448_altered_tumor_morphology0.73681256
97MP0009780_abnormal_chondrocyte_physiolo0.73439507
98MP0009384_cardiac_valve_regurgitation0.73025988
99MP0002085_abnormal_embryonic_tissue0.73000747
100MP0004510_myositis0.72885839

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.82265723
2Protrusio acetabuli (HP:0003179)4.53882948
3Increased connective tissue (HP:0009025)3.10896530
4Short nail (HP:0001799)3.04551912
5Osteolytic defects of the hand bones (HP:0009699)2.94690401
6Osteolytic defects of the phalanges of the hand (HP:0009771)2.94690401
7Hyperacusis (HP:0010780)2.94672709
8Vertebral compression fractures (HP:0002953)2.90703631
9Ulnar bowing (HP:0003031)2.82001823
10Broad face (HP:0000283)2.80603930
11Atrophic scars (HP:0001075)2.71508423
12Arterial tortuosity (HP:0005116)2.67486169
13Wormian bones (HP:0002645)2.61698302
14Fragile skin (HP:0001030)2.61021765
15Cerebral aneurysm (HP:0004944)2.59962583
16Flat acetabular roof (HP:0003180)2.53900870
17Vascular tortuosity (HP:0004948)2.53239522
18Ankyloglossia (HP:0010296)2.45859086
19Heterotopia (HP:0002282)2.44546536
20Thin bony cortex (HP:0002753)2.41533021
21Cervical subluxation (HP:0003308)2.40735218
22Ankle contracture (HP:0006466)2.36029754
23Aortic dissection (HP:0002647)2.35539499
24Distal lower limb amyotrophy (HP:0008944)2.35338532
25Disproportionate tall stature (HP:0001519)2.34906544
26Myocardial infarction (HP:0001658)2.34010770
27Abnormality of dentin (HP:0010299)2.33988023
28Long eyelashes (HP:0000527)2.30627506
29Abnormality of the acetabulum (HP:0003170)2.28138022
30Aortic aneurysm (HP:0004942)2.27136928
31Mitral valve prolapse (HP:0001634)2.25989688
32Spinal cord lesions (HP:0100561)2.24578564
33Syringomyelia (HP:0003396)2.24578564
34Spinal rigidity (HP:0003306)2.22604619
35Dilatation of the ascending aorta (HP:0005111)2.20627563
36Bladder diverticulum (HP:0000015)2.20544099
37Dislocated radial head (HP:0003083)2.18987475
38Mitral stenosis (HP:0001718)2.16300527
39Abnormality of oral frenula (HP:0000190)2.15617421
40Insomnia (HP:0100785)2.15356355
41Entropion (HP:0000621)2.14848150
42Blue sclerae (HP:0000592)2.12916180
43Shallow orbits (HP:0000586)2.12533028
44Insidious onset (HP:0003587)2.10643744
45Termporal pattern (HP:0011008)2.10643744
46Tibial bowing (HP:0002982)2.09575973
47Distal upper limb amyotrophy (HP:0007149)2.09438777
48Upper limb amyotrophy (HP:0009129)2.09438777
49Sparse lateral eyebrow (HP:0005338)2.09039904
50Achilles tendon contracture (HP:0001771)2.08999776
51Natal tooth (HP:0000695)2.04133987
52Abnormality of the distal phalanx of the thumb (HP:0009617)2.03007614
53Abnormality of the distal phalanges of the toes (HP:0010182)2.00695041
54Soft skin (HP:0000977)2.00008672
55Biconcave vertebral bodies (HP:0004586)1.99348089
56Aneurysm (HP:0002617)1.97459732
57Missing ribs (HP:0000921)1.97318600
58Subacute progressive viral hepatitis (HP:0006572)1.97042432
59Elbow flexion contracture (HP:0002987)1.96687583
60Neonatal short-limb short stature (HP:0008921)1.96672897
61Spondylolisthesis (HP:0003302)1.88160120
62Abnormality of the radial head (HP:0003995)1.87414493
63Mitral regurgitation (HP:0001653)1.86624461
64Genu recurvatum (HP:0002816)1.84801376
65Abnormality of the Achilles tendon (HP:0005109)1.84294298
66Abnormal ossification of hand bones (HP:0005921)1.84248972
67Joint laxity (HP:0001388)1.83251050
68Deep philtrum (HP:0002002)1.82488772
69Large earlobe (HP:0009748)1.82446365
70Difficulty climbing stairs (HP:0003551)1.82229500
71Reticulocytosis (HP:0001923)1.82125157
72Renal duplication (HP:0000075)1.81295312
73Long palpebral fissure (HP:0000637)1.76825557
74Asymmetry of the thorax (HP:0001555)1.76325832
75Centrally nucleated skeletal muscle fibers (HP:0003687)1.75404286
76Decreased motor nerve conduction velocity (HP:0003431)1.74869366
77Abnormality of carpal bone ossification (HP:0006257)1.74171633
78Trismus (HP:0000211)1.73995668
79Wide anterior fontanel (HP:0000260)1.73432650
80Cortical dysplasia (HP:0002539)1.72600761
81Delayed cranial suture closure (HP:0000270)1.71961981
82Peritonitis (HP:0002586)1.71678599
83Abnormal auditory evoked potentials (HP:0006958)1.71463190
84Spastic diplegia (HP:0001264)1.70284708
85Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.69321822
86Absent frontal sinuses (HP:0002688)1.69063114
87Increased variability in muscle fiber diameter (HP:0003557)1.68777626
88Deviation of the thumb (HP:0009603)1.68208252
89Overlapping toe (HP:0001845)1.66370061
90Hand muscle atrophy (HP:0009130)1.65906550
91Mild short stature (HP:0003502)1.65392375
92Hypopigmentation of the fundus (HP:0007894)1.65266748
93Upper limb muscle weakness (HP:0003484)1.65061421
94Hammertoe (HP:0001765)1.65008584
95Lower limb amyotrophy (HP:0007210)1.64790766
96Vertebral arch anomaly (HP:0008438)1.62870040
97Relative macrocephaly (HP:0004482)1.60110521
98Bowel diverticulosis (HP:0005222)1.59067582
99Limited elbow extension (HP:0001377)1.57834179
100Renovascular hypertension (HP:0100817)1.56810319

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.18516868
2ICK3.42010836
3IRAK33.25984828
4MST1R2.74218736
5PDGFRA2.66930774
6TTN2.52907536
7TRIB32.41277936
8EEF2K2.29164111
9MET2.10284404
10EIF2AK12.09714375
11PRPF4B2.00748308
12LATS21.99374355
13LATS11.90929195
14SCYL21.87582556
15SMG11.60734450
16PTK21.48273314
17MTOR1.47395653
18ERBB41.42405977
19PAK21.40313523
20TSSK61.38936839
21PAK41.38568287
22FGFR41.35109017
23CAMK1D1.34101585
24NTRK11.33935084
25MAP2K31.32524075
26WNK11.32337670
27RIPK11.28931991
28CAMK1G1.26767647
29NEK21.24517261
30PBK1.23189679
31TGFBR21.18849229
32KSR21.16849951
33PDGFRB1.16842320
34MOS1.12750538
35NEK91.12363811
36SIK11.11495279
37NEK11.10967643
38TTK1.09151988
39ERN11.08720254
40PKN21.07987943
41FLT31.05143362
42PNCK1.04231586
43MAP3K81.02342893
44PDK21.01665693
45DDR21.01180471
46CDK61.00694611
47BRD40.95566773
48CDK80.94448972
49TRPM70.94448198
50TAOK20.94426080
51EPHA20.93332838
52STK100.89964107
53SIK20.85947146
54STK380.85099171
55CDC70.84688583
56CDK70.81183665
57KSR10.80212688
58BRSK10.73699848
59MAP3K130.72643472
60BMX0.71277032
61CDK40.67287692
62CDC42BPA0.66493218
63IRAK20.66222196
64RAF10.65924933
65BRSK20.64825184
66MELK0.64007599
67PRKD20.63316940
68CHEK10.62974998
69ZAP700.62579389
70MAPK110.61994277
71EPHB10.60415398
72WEE10.60137625
73FGFR30.59849653
74CLK10.57263893
75JAK30.54861898
76CHEK20.54318174
77SGK30.53994597
78CDK90.52828131
79LMTK20.52619880
80MAP3K60.50841114
81RET0.50032175
82MAP3K30.49499421
83AURKB0.47378868
84SRPK10.47033647
85MAP3K100.44633490
86MAP3K140.43587674
87PDPK10.41249365
88NEK60.40262930
89STK40.40132038
90WNK40.39482924
91STK30.39124286
92MAPK100.39040695
93MARK20.37986694
94BUB10.36572084
95CDK10.36338418
96RPS6KA20.36139781
97RPS6KB20.35722894
98MAP3K10.33550241
99AKT20.33008569
100PTK60.32703369

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.23294232
2Chronic myeloid leukemia_Homo sapiens_hsa052202.15904945
3Small cell lung cancer_Homo sapiens_hsa052221.89148661
4Bladder cancer_Homo sapiens_hsa052191.82555165
5Pancreatic cancer_Homo sapiens_hsa052121.81881180
6ECM-receptor interaction_Homo sapiens_hsa045121.81775968
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.81146542
8Central carbon metabolism in cancer_Homo sapiens_hsa052301.74675810
9MicroRNAs in cancer_Homo sapiens_hsa052061.71692447
10Focal adhesion_Homo sapiens_hsa045101.71594489
11Non-small cell lung cancer_Homo sapiens_hsa052231.68183817
12Adherens junction_Homo sapiens_hsa045201.63265933
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.61593983
14Proteoglycans in cancer_Homo sapiens_hsa052051.55303452
15Renal cell carcinoma_Homo sapiens_hsa052111.52506441
16Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.49355820
17Other glycan degradation_Homo sapiens_hsa005111.44880806
18Amoebiasis_Homo sapiens_hsa051461.44519653
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.41362937
20Thyroid hormone signaling pathway_Homo sapiens_hsa049191.40476713
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35887387
22Cell cycle_Homo sapiens_hsa041101.32938148
23Endometrial cancer_Homo sapiens_hsa052131.32509754
24Prion diseases_Homo sapiens_hsa050201.28225734
25Glioma_Homo sapiens_hsa052141.26275051
26Acute myeloid leukemia_Homo sapiens_hsa052211.24381700
27Thyroid cancer_Homo sapiens_hsa052161.23859035
28Lysine degradation_Homo sapiens_hsa003101.17248654
29Prostate cancer_Homo sapiens_hsa052151.15542329
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12876656
31Hepatitis B_Homo sapiens_hsa051611.12666123
32Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.10280368
33DNA replication_Homo sapiens_hsa030301.09545483
34mTOR signaling pathway_Homo sapiens_hsa041501.09350304
35ErbB signaling pathway_Homo sapiens_hsa040121.08003427
36Inositol phosphate metabolism_Homo sapiens_hsa005621.06766318
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.06464955
38VEGF signaling pathway_Homo sapiens_hsa043701.06340639
39Viral carcinogenesis_Homo sapiens_hsa052031.05045840
40Neurotrophin signaling pathway_Homo sapiens_hsa047220.99321048
41Notch signaling pathway_Homo sapiens_hsa043300.97423763
42Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96088804
43Apoptosis_Homo sapiens_hsa042100.94658017
44Estrogen signaling pathway_Homo sapiens_hsa049150.92884619
45Regulation of actin cytoskeleton_Homo sapiens_hsa048100.92501750
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89263470
47Hippo signaling pathway_Homo sapiens_hsa043900.87199167
48HIF-1 signaling pathway_Homo sapiens_hsa040660.86974443
49Shigellosis_Homo sapiens_hsa051310.86800213
50Glycosaminoglycan degradation_Homo sapiens_hsa005310.85135940
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84351172
52Colorectal cancer_Homo sapiens_hsa052100.83170642
53Insulin signaling pathway_Homo sapiens_hsa049100.81801315
54TNF signaling pathway_Homo sapiens_hsa046680.81352206
55Nucleotide excision repair_Homo sapiens_hsa034200.81216978
56Toxoplasmosis_Homo sapiens_hsa051450.80574339
57Pathways in cancer_Homo sapiens_hsa052000.80040770
58HTLV-I infection_Homo sapiens_hsa051660.79618027
59GnRH signaling pathway_Homo sapiens_hsa049120.79414535
60TGF-beta signaling pathway_Homo sapiens_hsa043500.79322898
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79317823
62Influenza A_Homo sapiens_hsa051640.78391868
63PI3K-Akt signaling pathway_Homo sapiens_hsa041510.77016632
64mRNA surveillance pathway_Homo sapiens_hsa030150.76189662
65Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75875554
66Biosynthesis of amino acids_Homo sapiens_hsa012300.75709679
67Pentose phosphate pathway_Homo sapiens_hsa000300.75196149
68Gap junction_Homo sapiens_hsa045400.74738705
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74673759
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.74403669
71Fructose and mannose metabolism_Homo sapiens_hsa000510.73108273
72RNA transport_Homo sapiens_hsa030130.73089615
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72544445
74Melanoma_Homo sapiens_hsa052180.71848316
75Prolactin signaling pathway_Homo sapiens_hsa049170.71225227
76Osteoclast differentiation_Homo sapiens_hsa043800.70563763
77Endocytosis_Homo sapiens_hsa041440.70234256
78Dilated cardiomyopathy_Homo sapiens_hsa054140.69938527
79N-Glycan biosynthesis_Homo sapiens_hsa005100.69668858
80Malaria_Homo sapiens_hsa051440.68410373
81Salmonella infection_Homo sapiens_hsa051320.67833970
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67122981
83Choline metabolism in cancer_Homo sapiens_hsa052310.66456464
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65072552
85Galactose metabolism_Homo sapiens_hsa000520.64587443
86p53 signaling pathway_Homo sapiens_hsa041150.64472875
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64128131
88FoxO signaling pathway_Homo sapiens_hsa040680.63750514
89AMPK signaling pathway_Homo sapiens_hsa041520.63251007
90Oocyte meiosis_Homo sapiens_hsa041140.62514475
91Mismatch repair_Homo sapiens_hsa034300.60695517
92Non-homologous end-joining_Homo sapiens_hsa034500.60569243
93Insulin resistance_Homo sapiens_hsa049310.59705045
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59693615
95B cell receptor signaling pathway_Homo sapiens_hsa046620.59376689
96Measles_Homo sapiens_hsa051620.59149049
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.57170792
98Hepatitis C_Homo sapiens_hsa051600.55997487
99Platelet activation_Homo sapiens_hsa046110.54720842
100Legionellosis_Homo sapiens_hsa051340.53510024

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