SRI

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.89438523
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.57603065
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.36389612
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.05727408
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.05727408
6energy coupled proton transport, down electrochemical gradient (GO:0015985)5.04647187
7ATP synthesis coupled proton transport (GO:0015986)5.04647187
8regulation of cilium movement (GO:0003352)4.97555103
9antigen processing and presentation of endogenous antigen (GO:0019883)4.89277069
10respiratory electron transport chain (GO:0022904)4.74875152
11cullin deneddylation (GO:0010388)4.69530288
12electron transport chain (GO:0022900)4.66807326
13proteasome assembly (GO:0043248)4.53931526
14Arp2/3 complex-mediated actin nucleation (GO:0034314)4.45229026
15protein deneddylation (GO:0000338)4.32514429
16chaperone-mediated protein transport (GO:0072321)4.30079756
17respiratory chain complex IV assembly (GO:0008535)4.26222137
18neutrophil activation involved in immune response (GO:0002283)4.22874080
19leukocyte aggregation (GO:0070486)4.19480103
20negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.11341613
21establishment of protein localization to mitochondrial membrane (GO:0090151)4.06417804
22positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.02467138
23protein complex biogenesis (GO:0070271)4.00559161
24ribosomal small subunit assembly (GO:0000028)3.90910097
25cytochrome complex assembly (GO:0017004)3.87804497
26regulation of cellular amino acid metabolic process (GO:0006521)3.83390876
27aldehyde catabolic process (GO:0046185)3.81274110
28positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.79552255
29axonemal dynein complex assembly (GO:0070286)3.77064104
30oxidative phosphorylation (GO:0006119)3.76562069
31regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.74289012
32negative regulation of ligase activity (GO:0051352)3.73829445
33negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.73829445
34positive regulation of gamma-delta T cell activation (GO:0046645)3.72036240
35protein neddylation (GO:0045116)3.68202520
36mitochondrial respiratory chain complex assembly (GO:0033108)3.65351947
37cellular response to type I interferon (GO:0071357)3.62340316
38type I interferon signaling pathway (GO:0060337)3.62340316
39response to type I interferon (GO:0034340)3.61873304
40response to interferon-beta (GO:0035456)3.59096872
41DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.58579979
42sequestering of actin monomers (GO:0042989)3.52000322
43neurotransmitter uptake (GO:0001504)3.48076951
44anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.46875594
45signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.45543337
46intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.45543337
47mitochondrial respiratory chain complex I assembly (GO:0032981)3.45397213
48NADH dehydrogenase complex assembly (GO:0010257)3.45397213
49mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.45397213
50signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.45151182
51signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.45151182
52signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.45151182
53regulation of B cell receptor signaling pathway (GO:0050855)3.44167845
54epithelial cilium movement (GO:0003351)3.41292891
55actin nucleation (GO:0045010)3.37957081
56ATP biosynthetic process (GO:0006754)3.35621332
57cilium movement (GO:0003341)3.32618301
58respiratory burst (GO:0045730)3.32517585
59positive regulation of macrophage differentiation (GO:0045651)3.30500812
60neutrophil activation (GO:0042119)3.26978366
61regulation of mitochondrial translation (GO:0070129)3.25940852
62interferon-gamma-mediated signaling pathway (GO:0060333)3.25868997
63lipopolysaccharide biosynthetic process (GO:0009103)3.25319686
64water-soluble vitamin biosynthetic process (GO:0042364)3.25174635
65signal transduction involved in DNA integrity checkpoint (GO:0072401)3.25027191
66signal transduction involved in DNA damage checkpoint (GO:0072422)3.25027191
67signal transduction involved in cell cycle checkpoint (GO:0072395)3.23386309
68myeloid dendritic cell activation (GO:0001773)3.22977582
69cellular response to interferon-beta (GO:0035458)3.20889633
70hepatocyte apoptotic process (GO:0097284)3.20284491
71purine nucleoside triphosphate biosynthetic process (GO:0009145)3.19659092
72platelet dense granule organization (GO:0060155)3.19646365
73hydrogen ion transmembrane transport (GO:1902600)3.19384987
74establishment of integrated proviral latency (GO:0075713)3.19115281
75negative thymic T cell selection (GO:0045060)3.18606728
76positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.18074774
77immunoglobulin mediated immune response (GO:0016064)3.17992154
78nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.17481930
79transcription elongation from RNA polymerase III promoter (GO:0006385)3.14843333
80termination of RNA polymerase III transcription (GO:0006386)3.14843333
81defense response to protozoan (GO:0042832)3.14448476
82positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.14091972
83purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.13759950
84negative T cell selection (GO:0043383)3.13295310
85interferon-gamma production (GO:0032609)3.12864358
86antigen processing and presentation via MHC class Ib (GO:0002475)3.12165533
87axoneme assembly (GO:0035082)3.08314719
88nonmotile primary cilium assembly (GO:0035058)3.07978061
89proton transport (GO:0015992)3.07367067
90granulocyte activation (GO:0036230)3.07242183
91rRNA modification (GO:0000154)3.05927587
92exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.05664651
93tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.05494008
94RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.05494008
95T cell migration (GO:0072678)3.04702961
96viral transcription (GO:0019083)3.03748148
97cellular response to zinc ion (GO:0071294)3.03617659
98hydrogen transport (GO:0006818)3.03499697
99positive regulation of ligase activity (GO:0051351)3.03345836
100positive regulation of alpha-beta T cell proliferation (GO:0046641)3.03276439
101signal peptide processing (GO:0006465)3.00950557
102response to protozoan (GO:0001562)3.00547652
103NIK/NF-kappaB signaling (GO:0038061)3.00107970
104regulation of T cell receptor signaling pathway (GO:0050856)3.00059061
105regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.99807776
106dendritic cell chemotaxis (GO:0002407)2.98887872
107regulation of alpha-beta T cell proliferation (GO:0046640)2.98357629
108response to peptidoglycan (GO:0032494)2.98339068
109mast cell activation (GO:0045576)2.98085237
110epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.97237656
111intraciliary transport (GO:0042073)2.95863996
112myeloid dendritic cell differentiation (GO:0043011)2.95676608
113positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.95277647
114protein targeting to mitochondrion (GO:0006626)2.93910067
115regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.91161794
116hyperosmotic salinity response (GO:0042538)2.91021227
117regulation of respiratory burst (GO:0060263)2.90854574
118deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.90704490
119cellular extravasation (GO:0045123)2.89013857
120regulation of microtubule-based movement (GO:0060632)2.86054777
121regulation of T cell tolerance induction (GO:0002664)2.85761559
122leukocyte cell-cell adhesion (GO:0007159)2.84702485
123positive regulation of natural killer cell differentiation (GO:0032825)2.84021640
124regulation of RIG-I signaling pathway (GO:0039535)2.83247560
125regulation of T-helper 1 cell differentiation (GO:0045625)2.82494726
126positive regulation of interferon-alpha production (GO:0032727)2.82278040
127SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.82261692
128translational termination (GO:0006415)2.81617384
129C4-dicarboxylate transport (GO:0015740)2.80706237
130cellular response to interleukin-15 (GO:0071350)2.80301501
131regulation of ubiquitin-protein transferase activity (GO:0051438)2.79126844
132presynaptic membrane assembly (GO:0097105)2.78897429
133B cell mediated immunity (GO:0019724)2.78692789
134nucleoside triphosphate biosynthetic process (GO:0009142)2.77355590
135protein targeting to ER (GO:0045047)2.77149680
136cotranslational protein targeting to membrane (GO:0006613)2.76887455
137protein localization to mitochondrion (GO:0070585)2.76582681
138regulation of cellular amine metabolic process (GO:0033238)2.75950263
139mannosylation (GO:0097502)2.74583654
140response to interferon-alpha (GO:0035455)2.74433134
141ribonucleoside triphosphate biosynthetic process (GO:0009201)2.74321631
142establishment of protein localization to mitochondrion (GO:0072655)2.73668224
143antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.73615863
144L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.73492633
145glutathione derivative biosynthetic process (GO:1901687)2.71969263
146glutathione derivative metabolic process (GO:1901685)2.71969263
147regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.71608618
148regulation of B cell differentiation (GO:0045577)2.71346827
149branched-chain amino acid catabolic process (GO:0009083)2.70706376
150dendritic cell migration (GO:0036336)2.70236159
151DNA deamination (GO:0045006)2.69613416
152regulation of ligase activity (GO:0051340)2.68420361
153regulation of interferon-alpha production (GO:0032647)2.68305160
154response to interleukin-15 (GO:0070672)2.67770897
155cilium or flagellum-dependent cell motility (GO:0001539)2.66916477
156DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.66765122
157regulation of response to interferon-gamma (GO:0060330)2.66408700
158cellular response to leptin stimulus (GO:0044320)2.66180287
159establishment of viral latency (GO:0019043)2.65416736
160protein localization to endoplasmic reticulum (GO:0070972)2.64921965
161deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.64571595
162lactate metabolic process (GO:0006089)2.64353068
163mature B cell differentiation involved in immune response (GO:0002313)2.63979057
164postsynaptic membrane organization (GO:0001941)2.63107972
165ribosomal small subunit biogenesis (GO:0042274)2.62428032
1662-deoxyribonucleotide biosynthetic process (GO:0009265)2.62407104
167deoxyribose phosphate biosynthetic process (GO:0046385)2.62407104
168regulation of interleukin-12 biosynthetic process (GO:0045075)2.62366024
169spliceosomal snRNP assembly (GO:0000387)2.61824040
170protein-cofactor linkage (GO:0018065)2.60723105
171establishment of protein localization to endoplasmic reticulum (GO:0072599)2.60695395
172leukocyte degranulation (GO:0043299)2.59430767
173intracellular protein transmembrane import (GO:0044743)2.59403062
174positive regulation of lamellipodium assembly (GO:0010592)2.59350223
175mature B cell differentiation (GO:0002335)2.58663529
176positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.57851095
177regulation of gamma-delta T cell differentiation (GO:0045586)2.57825486
178protein heterotetramerization (GO:0051290)2.57161646
179GPI anchor biosynthetic process (GO:0006506)2.57104243
180positive regulation of antigen processing and presentation (GO:0002579)2.56493131
181negative regulation of viral genome replication (GO:0045071)2.55413986
182CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.53963291
183regulation of tolerance induction (GO:0002643)2.52406752
184barbed-end actin filament capping (GO:0051016)2.52005108
185regulation of natural killer cell differentiation (GO:0032823)2.51322089
186positive regulation of interleukin-2 production (GO:0032743)2.50041698
187negative regulation of phagocytosis (GO:0050765)2.49879963
188regulation of isotype switching to IgG isotypes (GO:0048302)2.49697357
189regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.49523310
190myeloid cell activation involved in immune response (GO:0002275)2.48851717
191response to muramyl dipeptide (GO:0032495)2.47326803
192dendritic cell differentiation (GO:0097028)2.47207872
193regulation of necrotic cell death (GO:0010939)2.45903906
194regulation of T cell mediated cytotoxicity (GO:0001914)2.45779016
195positive regulation of T cell mediated cytotoxicity (GO:0001916)2.45029031
196B cell receptor signaling pathway (GO:0050853)2.44882738
197positive regulation of B cell differentiation (GO:0045579)2.44429436
198negative regulation of T cell receptor signaling pathway (GO:0050860)2.43161862
199natural killer cell activation (GO:0030101)2.43150539
200tumor necrosis factor-mediated signaling pathway (GO:0033209)2.41944420

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.73357201
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.97806039
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.90063112
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.57602648
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.51988926
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.34412920
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.80978022
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.59356780
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.53426891
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.49405182
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.41428601
12* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.18669490
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.07540369
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.97337166
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.96061185
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.84492661
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.80893641
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.79921946
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.78051675
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.68880227
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.61345769
22TP63_17297297_ChIP-ChIP_HaCaT_Human2.59577648
23* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.54835921
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.52752026
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.49115935
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.46738613
27ETS1_20019798_ChIP-Seq_JURKAT_Human2.43870698
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.43783896
29SPI1_23547873_ChIP-Seq_NB4_Human2.38942135
30* MYB_26560356_Chip-Seq_TH2_Human2.31748682
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.29390696
32RUNX_20019798_ChIP-Seq_JUKART_Human2.24289500
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.13036753
34SCL_19346495_ChIP-Seq_HPC-7_Human2.07938008
35ELF1_17652178_ChIP-ChIP_JURKAT_Human2.07039698
36VDR_22108803_ChIP-Seq_LS180_Human2.04606616
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02933410
38ZNF274_21170338_ChIP-Seq_K562_Hela1.99627461
39MYC_18555785_ChIP-Seq_MESCs_Mouse1.98411199
40MAF_26560356_Chip-Seq_TH1_Human1.96621842
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96162377
42VDR_24763502_ChIP-Seq_THP-1_Human1.90027633
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.88551188
44IGF1R_20145208_ChIP-Seq_DFB_Human1.86387818
45* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.85971984
46MYB_26560356_Chip-Seq_TH1_Human1.84193078
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.82689291
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78988327
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78060034
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75497103
51* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.72889438
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.71741937
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69156591
54TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.69108853
55EWS_26573619_Chip-Seq_HEK293_Human1.66716805
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66410103
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63853502
58* FOXP3_21729870_ChIP-Seq_TREG_Human1.62660239
59Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.61316481
60BRD4_27068464_Chip-Seq_AML-cells_Mouse1.60730332
61MYC_18940864_ChIP-ChIP_HL60_Human1.59841591
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.57429947
63MYC_18358816_ChIP-ChIP_MESCs_Mouse1.57212562
64* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.56897149
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.56459302
66* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56273906
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.56032340
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51144851
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51074855
70E2F4_17652178_ChIP-ChIP_JURKAT_Human1.51063661
71FUS_26573619_Chip-Seq_HEK293_Human1.50015383
72ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49877967
73EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.49578385
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.49341936
75UTX_26944678_Chip-Seq_JUKART_Human1.48492162
76SPI1_23127762_ChIP-Seq_K562_Human1.48449512
77HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.48044566
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47867719
79HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47444424
80HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47293919
81NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46064067
82VDR_21846776_ChIP-Seq_THP-1_Human1.45798974
83CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44980304
84CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.44663162
85* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44190291
86PU_27001747_Chip-Seq_BMDM_Mouse1.43172777
87GATA1_22025678_ChIP-Seq_K562_Human1.43072655
88DCP1A_22483619_ChIP-Seq_HELA_Human1.41829359
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.41828640
90HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.41616286
91GATA2_22383799_ChIP-Seq_G1ME_Mouse1.38817716
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35844860
93P300_19829295_ChIP-Seq_ESCs_Human1.35785123
94NOTCH1_21737748_ChIP-Seq_TLL_Human1.35582917
95GATA1_22383799_ChIP-Seq_G1ME_Mouse1.35394040
96POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32471130
97* SOX2_20726797_ChIP-Seq_SW620_Human1.31540587
98CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30898521
99GBX2_23144817_ChIP-Seq_PC3_Human1.30815789
100PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30212386
101GABP_17652178_ChIP-ChIP_JURKAT_Human1.30041392
102CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29747499
103YY1_21170310_ChIP-Seq_MESCs_Mouse1.29708025
104GABP_19822575_ChIP-Seq_HepG2_Human1.29552090
105MYC_19030024_ChIP-ChIP_MESCs_Mouse1.28963906
106CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28728966
107CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28215882
108CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.26867646
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26387873
110CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26200849
111ELK1_19687146_ChIP-ChIP_HELA_Human1.26075575
112GATA3_27048872_Chip-Seq_THYMUS_Human1.24547741
113MAF_26560356_Chip-Seq_TH2_Human1.23623848
114* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.16515282
115E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16321353
116THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15883692
117GATA3_26560356_Chip-Seq_TH2_Human1.14519978
118CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14053009
119CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14046345
120EGR1_19032775_ChIP-ChIP_M12_Human1.13815678
121VDR_24787735_ChIP-Seq_THP-1_Human1.13765057
122TTF2_22483619_ChIP-Seq_HELA_Human1.12748508
123NANOG_19829295_ChIP-Seq_ESCs_Human1.11554554
124SOX2_19829295_ChIP-Seq_ESCs_Human1.11554554
125SMAD_19615063_ChIP-ChIP_OVARY_Human1.10123412
126NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09819379
127PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09140795
128GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08717926
129* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05935063
130AR_20517297_ChIP-Seq_VCAP_Human1.05773069
131YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04811367
132* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04752582
133* FOXA1_25329375_ChIP-Seq_VCAP_Human1.04752582
134MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04145987
135PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03624376
136SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03202301
137TP53_22573176_ChIP-Seq_HFKS_Human1.02395197
138* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02072375
139EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02070909
140ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01935725
141PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01782432
142* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01058560
143RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98558719
144ELK1_22589737_ChIP-Seq_MCF10A_Human0.97595549
145NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96782737
146SRF_21415370_ChIP-Seq_HL-1_Mouse0.96045164
147TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96037144
148ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95659024
149PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95567894
150ELK3_25401928_ChIP-Seq_HUVEC_Human0.94678925
151IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94608298
152CBP_20019798_ChIP-Seq_JUKART_Human0.94608298
153CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93913759
154VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93832201
155* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93338252
156ERG_20517297_ChIP-Seq_VCAP_Human0.93199427
157SOX2_16153702_ChIP-ChIP_HESCs_Human0.92978786
158VDR_23849224_ChIP-Seq_CD4+_Human0.92937872
159SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92707450
160ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.92677671
161OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92570725
162RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92415292
163PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92293686
164TAF15_26573619_Chip-Seq_HEK293_Human0.92096543
165HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91376899
166NFE2_27457419_Chip-Seq_LIVER_Mouse0.91352073
167* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90712495
168* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90712495
169SALL4_22934838_ChIP-ChIP_CD34+_Human0.90360981
170TAL1_26923725_Chip-Seq_HPCs_Mouse0.90299958
171TCF4_22108803_ChIP-Seq_LS180_Human0.90001281
172TRIM28_21343339_ChIP-Seq_HEK293_Human0.89861584
173* CDX2_20551321_ChIP-Seq_CACO-2_Human0.89268661
174P53_22387025_ChIP-Seq_ESCs_Mouse0.88264660
175NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.88181892
176GATA1_19941827_ChIP-Seq_MEL_Mouse0.87088134
177CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86985885
178EZH2_27294783_Chip-Seq_NPCs_Mouse0.86758769
179NANOG_16153702_ChIP-ChIP_HESCs_Human0.86532457
180EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85844224
181NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85680660
182PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.85577890
183IRF1_19129219_ChIP-ChIP_H3396_Human0.83929388
184CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82027376
185FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.81786857
186CDX2_19796622_ChIP-Seq_MESCs_Mouse0.76641202
187TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76162242

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.23750152
2MP0009785_altered_susceptibility_to3.64777400
3MP0003724_increased_susceptibility_to3.63265156
4MP0001984_abnormal_olfaction3.54769440
5MP0005671_abnormal_response_to3.33391218
6MP0000685_abnormal_immune_system3.22779040
7MP0003880_abnormal_central_pattern3.22363920
8MP0002148_abnormal_hypersensitivity_rea3.17074233
9MP0008789_abnormal_olfactory_epithelium3.16866694
10MP0003436_decreased_susceptibility_to2.91436456
11MP0005000_abnormal_immune_tolerance2.83846710
12MP0005025_abnormal_response_to2.79636314
13MP0002736_abnormal_nociception_after2.71588579
14MP0003806_abnormal_nucleotide_metabolis2.69814526
15MP0001790_abnormal_immune_system2.68172796
16MP0005387_immune_system_phenotype2.68172796
17MP0001800_abnormal_humoral_immune2.57719003
18MP0002452_abnormal_antigen_presenting2.51512773
19MP0002166_altered_tumor_susceptibility2.49978376
20MP0002419_abnormal_innate_immunity2.49834795
21MP0002723_abnormal_immune_serum2.42763756
22MP0002420_abnormal_adaptive_immunity2.42685558
23MP0001819_abnormal_immune_cell2.42276433
24MP0003763_abnormal_thymus_physiology2.40321444
25MP0001529_abnormal_vocalization2.35648386
26MP0010155_abnormal_intestine_physiology2.32487983
27MP0006072_abnormal_retinal_apoptosis2.32253742
28MP0003303_peritoneal_inflammation2.32048630
29MP0008058_abnormal_DNA_repair2.29813263
30MP0005394_taste/olfaction_phenotype2.23131817
31MP0005499_abnormal_olfactory_system2.23131817
32MP0002006_tumorigenesis2.20775907
33MP0009379_abnormal_foot_pigmentation2.16439445
34MP0001905_abnormal_dopamine_level2.11216925
35MP0004043_abnormal_pH_regulation2.10606895
36MP0002653_abnormal_ependyma_morphology2.10128526
37MP0009333_abnormal_splenocyte_physiolog2.09654700
38MP0002405_respiratory_system_inflammati2.05668753
39MP0003136_yellow_coat_color2.04345518
40MP0006082_CNS_inflammation2.03124753
41MP0003718_maternal_effect2.01472627
42MP0003866_abnormal_defecation2.00721298
43MP0001873_stomach_inflammation1.99802768
44MP0005253_abnormal_eye_physiology1.97263714
45MP0002398_abnormal_bone_marrow1.91089847
46MP0005464_abnormal_platelet_physiology1.90682320
47MP0006054_spinal_hemorrhage1.88509282
48MP0001486_abnormal_startle_reflex1.87099407
49MP0005551_abnormal_eye_electrophysiolog1.86596417
50MP0000716_abnormal_immune_system1.84543412
51MP0006036_abnormal_mitochondrial_physio1.83843392
52MP0001853_heart_inflammation1.83808237
53MP0003300_gastrointestinal_ulcer1.79903428
54MP0001845_abnormal_inflammatory_respons1.79159316
55MP0001968_abnormal_touch/_nociception1.77641059
56MP0001485_abnormal_pinna_reflex1.77468453
57MP0001533_abnormal_skeleton_physiology1.73054600
58MP0002272_abnormal_nervous_system1.71580205
59MP0002396_abnormal_hematopoietic_system1.70672716
60MP0002734_abnormal_mechanical_nocicepti1.66000033
61MP0000490_abnormal_crypts_of1.65248287
62MP0004947_skin_inflammation1.63988636
63MP0002138_abnormal_hepatobiliary_system1.62966986
64MP0008875_abnormal_xenobiotic_pharmacok1.62762022
65MP0006276_abnormal_autonomic_nervous1.59903299
66MP0000465_gastrointestinal_hemorrhage1.57774922
67MP0009745_abnormal_behavioral_response1.57332510
68MP0002102_abnormal_ear_morphology1.56746261
69MP0004510_myositis1.55358507
70MP0000858_altered_metastatic_potential1.53903255
71MP0002429_abnormal_blood_cell1.53636004
72MP0005085_abnormal_gallbladder_physiolo1.53421172
73MP0005645_abnormal_hypothalamus_physiol1.52621169
74MP0000689_abnormal_spleen_morphology1.51185554
75MP0008872_abnormal_physiological_respon1.49804871
76MP0003011_delayed_dark_adaptation1.49682876
77MP0002722_abnormal_immune_system1.49648499
78MP0005397_hematopoietic_system_phenotyp1.47356302
79MP0001545_abnormal_hematopoietic_system1.47356302
80MP0001764_abnormal_homeostasis1.43553695
81MP0005084_abnormal_gallbladder_morpholo1.43466548
82MP0004270_analgesia1.43421853
83MP0001970_abnormal_pain_threshold1.41428322
84MP0003693_abnormal_embryo_hatching1.41349197
85MP0009764_decreased_sensitivity_to1.40971834
86MP0002933_joint_inflammation1.39249823
87MP0008469_abnormal_protein_level1.38979178
88MP0004019_abnormal_vitamin_homeostasis1.38582718
89MP0001663_abnormal_digestive_system1.38216675
90MP0000372_irregular_coat_pigmentation1.35105135
91MP0005636_abnormal_mineral_homeostasis1.33619543
92MP0005058_abnormal_lysosome_morphology1.29019629
93MP0004215_abnormal_myocardial_fiber1.28952669
94MP0004885_abnormal_endolymph1.28359365
95MP0005310_abnormal_salivary_gland1.27247725
96MP0002638_abnormal_pupillary_reflex1.25702222
97MP0004142_abnormal_muscle_tone1.25354179
98MP0000343_altered_response_to1.23180359
99MP0002572_abnormal_emotion/affect_behav1.22496491
100MP0006292_abnormal_olfactory_placode1.20996767
101MP0004957_abnormal_blastocyst_morpholog1.20037687
102MP0002064_seizures1.19497478
103MP0002090_abnormal_vision1.19464367
104MP0003448_altered_tumor_morphology1.17396659
105MP0001501_abnormal_sleep_pattern1.16485380
106MP0005360_urolithiasis1.16238007
107MP0005646_abnormal_pituitary_gland1.16208214
108MP0002733_abnormal_thermal_nociception1.15681692
109MP0000516_abnormal_urinary_system1.14923563
110MP0005367_renal/urinary_system_phenotyp1.14923563
111MP0002009_preneoplasia1.14109269
112MP0003186_abnormal_redox_activity1.13503083
113MP0010386_abnormal_urinary_bladder1.13330973
114MP0008004_abnormal_stomach_pH1.09908910
115MP0009046_muscle_twitch1.09310472
116MP0002822_catalepsy1.09248827
117MP0002998_abnormal_bone_remodeling1.08802844
118MP0005174_abnormal_tail_pigmentation1.07361184
119MP0005423_abnormal_somatic_nervous1.06788239
120MP0001502_abnormal_circadian_rhythm1.06558478
121MP0005332_abnormal_amino_acid1.06085840
122MP0004808_abnormal_hematopoietic_stem1.05456643
123MP0008877_abnormal_DNA_methylation1.05250157
124MP0001963_abnormal_hearing_physiology1.04743739
125MP0001986_abnormal_taste_sensitivity1.03408220
126MP0003828_pulmonary_edema1.02816935
127MP0002132_abnormal_respiratory_system1.02508239
128MP0002735_abnormal_chemical_nociception1.01633887
129MP0000703_abnormal_thymus_morphology1.01548292
130MP0010094_abnormal_chromosome_stability0.99570588
131MP0003191_abnormal_cellular_cholesterol0.99256054
132MP0003635_abnormal_synaptic_transmissio0.98026514
133MP0002557_abnormal_social/conspecific_i0.96122608
134MP0000015_abnormal_ear_pigmentation0.95108325
135MP0004133_heterotaxia0.95100323
136MP0008932_abnormal_embryonic_tissue0.94788993
137MP0009278_abnormal_bone_marrow0.93655919
138MP0001958_emphysema0.93150704
139MP0002277_abnormal_respiratory_mucosa0.91458963
140MP0002876_abnormal_thyroid_physiology0.90620281
141MP0000026_abnormal_inner_ear0.90597170
142MP0001348_abnormal_lacrimal_gland0.90539060
143MP0008007_abnormal_cellular_replicative0.90405240
144MP0009697_abnormal_copulation0.90387087
145MP0002233_abnormal_nose_morphology0.90261953
146MP0003786_premature_aging0.89747785
147MP0001664_abnormal_digestion0.89513798
148MP0005381_digestive/alimentary_phenotyp0.88676615
149MP0004147_increased_porphyrin_level0.88364030
150MP0001879_abnormal_lymphatic_vessel0.88007539
151MP0002139_abnormal_hepatobiliary_system0.87172238
152MP0001188_hyperpigmentation0.86649499
153MP0002067_abnormal_sensory_capabilities0.86275615
154MP0004782_abnormal_surfactant_physiolog0.86245056
155MP0002938_white_spotting0.85274640
156MP0001293_anophthalmia0.84442086
157MP0003656_abnormal_erythrocyte_physiolo0.84421653
158MP0003075_altered_response_to0.82869919
159MP0000249_abnormal_blood_vessel0.82420599
160MP0001756_abnormal_urination0.81714955
161MP0001851_eye_inflammation0.81252758
162MP0005165_increased_susceptibility_to0.79804509
163MP0005390_skeleton_phenotype0.79253270
164MP0002163_abnormal_gland_morphology0.79071794
165MP0002234_abnormal_pharynx_morphology0.78512740
166MP0005195_abnormal_posterior_eye0.78462507
167MP0004859_abnormal_synaptic_plasticity0.77955901
168MP0003279_aneurysm0.77697543
169MP0002063_abnormal_learning/memory/cond0.77425981
170MP0006035_abnormal_mitochondrial_morpho0.77347306
171MP0000647_abnormal_sebaceous_gland0.77123492
172MP0002136_abnormal_kidney_physiology0.76793045
173MP0005166_decreased_susceptibility_to0.76460141
174MP0002909_abnormal_adrenal_gland0.75691060
175MP0003633_abnormal_nervous_system0.75077250
176MP0000631_abnormal_neuroendocrine_gland0.74681150
177MP0002877_abnormal_melanocyte_morpholog0.74106931
178MP0001542_abnormal_bone_strength0.73715476
179MP0009763_increased_sensitivity_to0.73148859
180MP0002095_abnormal_skin_pigmentation0.73139491
181MP0000778_abnormal_nervous_system0.72984437
182MP0002751_abnormal_autonomic_nervous0.72574643
183MP0000477_abnormal_intestine_morphology0.72371362
184MP0002282_abnormal_trachea_morphology0.72352429
185MP0009643_abnormal_urine_homeostasis0.65687354
186MP0003795_abnormal_bone_structure0.64274897
187MP0003183_abnormal_peptide_metabolism0.63004854
188MP0005164_abnormal_response_to0.62008223
189MP0005167_abnormal_blood-brain_barrier0.61553473
190MP0002019_abnormal_tumor_incidence0.60422699
191MP0002928_abnormal_bile_duct0.60310762

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.31296142
2Eczematoid dermatitis (HP:0000976)5.08661326
3Elevated erythrocyte sedimentation rate (HP:0003565)4.97683346
4Acute necrotizing encephalopathy (HP:0006965)4.56152578
5Recurrent bacterial skin infections (HP:0005406)4.33589357
6Mitochondrial inheritance (HP:0001427)4.30286834
7Hepatocellular necrosis (HP:0001404)4.26881249
8Abnormal mitochondria in muscle tissue (HP:0008316)4.22745700
9Progressive macrocephaly (HP:0004481)4.21503161
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.14402636
11Acute encephalopathy (HP:0006846)4.12434314
12Myositis (HP:0100614)3.85860803
13Hepatic necrosis (HP:0002605)3.80001731
14Chronic otitis media (HP:0000389)3.79659373
15Increased CSF lactate (HP:0002490)3.77906744
16Recurrent fungal infections (HP:0002841)3.67294613
17Abnormal respiratory motile cilium physiology (HP:0012261)3.54521545
18Petechiae (HP:0000967)3.53591461
19Abnormal respiratory motile cilium morphology (HP:0005938)3.52635841
20Abnormal respiratory epithelium morphology (HP:0012253)3.52635841
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.45187123
22Decreased activity of mitochondrial respiratory chain (HP:0008972)3.45187123
23Abnormality of macrophages (HP:0004311)3.38404149
24Autoimmune thrombocytopenia (HP:0001973)3.37976680
25Abnormal ciliary motility (HP:0012262)3.37118041
26Rhinitis (HP:0012384)3.35517718
27Increased IgM level (HP:0003496)3.33919207
28Obstructive lung disease (HP:0006536)3.30164983
29Chronic obstructive pulmonary disease (HP:0006510)3.30164983
30Mediastinal lymphadenopathy (HP:0100721)3.28176942
31Stomatitis (HP:0010280)3.27703311
32Recurrent skin infections (HP:0001581)3.27602602
33Medial flaring of the eyebrow (HP:0010747)3.26060323
34Cerebral edema (HP:0002181)3.23874619
35Vasculitis (HP:0002633)3.16578165
36Vacuolated lymphocytes (HP:0001922)3.16059573
37True hermaphroditism (HP:0010459)3.15587096
38Recurrent viral infections (HP:0004429)3.12630497
39Gait imbalance (HP:0002141)3.12351302
40Thrombocytosis (HP:0001894)3.10476016
41Orchitis (HP:0100796)3.10255509
42Lipid accumulation in hepatocytes (HP:0006561)3.09235267
43Congenital primary aphakia (HP:0007707)3.08425000
44IgM deficiency (HP:0002850)3.06862697
45Recurrent bronchitis (HP:0002837)3.06635524
46Recurrent cutaneous fungal infections (HP:0011370)3.04901104
47Chronic mucocutaneous candidiasis (HP:0002728)3.04901104
48Meningitis (HP:0001287)3.02653086
49Absent/shortened dynein arms (HP:0200106)2.93596461
50Dynein arm defect of respiratory motile cilia (HP:0012255)2.93596461
51Pancreatic fibrosis (HP:0100732)2.89764185
52Abnormality of T cell number (HP:0011839)2.88175666
53Reduced antithrombin III activity (HP:0001976)2.84465181
54Retrobulbar optic neuritis (HP:0100654)2.83194915
55Optic neuritis (HP:0100653)2.83194915
56Pancreatic cysts (HP:0001737)2.82868719
57Respiratory failure (HP:0002878)2.82693686
58Nephrogenic diabetes insipidus (HP:0009806)2.80324709
59Recurrent gram-negative bacterial infections (HP:0005420)2.79739380
60Abnormality of T cell physiology (HP:0011840)2.79267466
61Abnormality of T cells (HP:0002843)2.78906364
62Severe combined immunodeficiency (HP:0004430)2.78904509
63Autoimmune hemolytic anemia (HP:0001890)2.76747154
643-Methylglutaconic aciduria (HP:0003535)2.74098754
65Interstitial pulmonary disease (HP:0006530)2.73754543
66Cellulitis (HP:0100658)2.72607361
67Prolonged bleeding time (HP:0003010)2.71040499
68Pustule (HP:0200039)2.69885953
69Lactic acidosis (HP:0003128)2.68658912
70Hypergammaglobulinemia (HP:0010702)2.66117735
71Abnormality of midbrain morphology (HP:0002418)2.65533330
72Molar tooth sign on MRI (HP:0002419)2.65533330
73T lymphocytopenia (HP:0005403)2.65269011
74CNS demyelination (HP:0007305)2.64200213
75Methylmalonic aciduria (HP:0012120)2.61535610
76Eosinophilia (HP:0001880)2.61236310
77Hyperglycinemia (HP:0002154)2.60623162
78Increased intramyocellular lipid droplets (HP:0012240)2.60356988
79Methylmalonic acidemia (HP:0002912)2.59899629
80Chronic bronchitis (HP:0004469)2.59798308
81Leukocytosis (HP:0001974)2.59434300
82Panhypogammaglobulinemia (HP:0003139)2.57681551
83Gingivitis (HP:0000230)2.53856104
84Type I transferrin isoform profile (HP:0003642)2.52060476
85Chronic diarrhea (HP:0002028)2.51909467
86Renal Fanconi syndrome (HP:0001994)2.50021685
87IgG deficiency (HP:0004315)2.49975265
88Purpura (HP:0000979)2.49835853
89Abnormal delayed hypersensitivity skin test (HP:0002963)2.49808905
90Exertional dyspnea (HP:0002875)2.49801082
91Agammaglobulinemia (HP:0004432)2.47388180
92Aplasia/Hypoplasia of the sacrum (HP:0008517)2.47334096
93Leukodystrophy (HP:0002415)2.46847573
94Hyperactive renin-angiotensin system (HP:0000841)2.46464302
95Granulocytopenia (HP:0001913)2.45736495
96Increased serum lactate (HP:0002151)2.45681061
97Combined immunodeficiency (HP:0005387)2.45306755
98Abnormality of serine family amino acid metabolism (HP:0010894)2.44465241
99Abnormality of glycine metabolism (HP:0010895)2.44465241
100Degeneration of anterior horn cells (HP:0002398)2.44237522
101Abnormality of the anterior horn cell (HP:0006802)2.44237522
102Hyperglycinuria (HP:0003108)2.43568173
103Abnormality of eosinophils (HP:0001879)2.43331913
104Gastrointestinal stroma tumor (HP:0100723)2.42568607
105B lymphocytopenia (HP:0010976)2.42189573
106Abnormality of B cell number (HP:0010975)2.42189573
107Lymphopenia (HP:0001888)2.42188123
108Lethargy (HP:0001254)2.41879139
109Hemoptysis (HP:0002105)2.41337333
110Abnormality of the nasal mucosa (HP:0000433)2.39739723
111Abnormality of the vitamin B12 metabolism (HP:0004341)2.39150403
112Abnormality of cells of the lymphoid lineage (HP:0012140)2.39134730
113Thyroiditis (HP:0100646)2.38999272
114Abnormality of cells of the erythroid lineage (HP:0012130)2.37928149
115Optic disc pallor (HP:0000543)2.35859075
116Increased serum pyruvate (HP:0003542)2.35574353
117Abnormality of the prostate (HP:0008775)2.34553247
118Abnormal number of erythroid precursors (HP:0012131)2.33445110
119Gastrointestinal infarctions (HP:0005244)2.32886236
120Abnormal hemoglobin (HP:0011902)2.30550659
121Vertebral compression fractures (HP:0002953)2.30481322
122Nasal polyposis (HP:0100582)2.29683354
123Abnormality of vitamin B metabolism (HP:0004340)2.29067159
124Bronchiectasis (HP:0002110)2.28655391
125Metabolic alkalosis (HP:0200114)2.28273401
126Reticulocytopenia (HP:0001896)2.26142387
127Periodontitis (HP:0000704)2.24187978
128Urticaria (HP:0001025)2.23673119
129Abnormality of dicarboxylic acid metabolism (HP:0010995)2.22140938
130Dicarboxylic aciduria (HP:0003215)2.22140938
131Myokymia (HP:0002411)2.21897739
132Pulmonary infiltrates (HP:0002113)2.21391766
133Nephronophthisis (HP:0000090)2.21359909
134Recurrent pneumonia (HP:0006532)2.18665796
135Exercise intolerance (HP:0003546)2.17937626
136Basal ganglia calcification (HP:0002135)2.17347927
137Congenital, generalized hypertrichosis (HP:0004540)2.17120763
138Genital tract atresia (HP:0001827)2.16623164
139Abnormality of renin-angiotensin system (HP:0000847)2.16130009
140Abnormality of serum amino acid levels (HP:0003112)2.15375251
141Increased muscle lipid content (HP:0009058)2.14883447
142Colon cancer (HP:0003003)2.14755353
143Abnormality of glycolysis (HP:0004366)2.14280765
144Vaginal atresia (HP:0000148)2.14079178
145Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.13771489
146Epistaxis (HP:0000421)2.13610276
147Emotional lability (HP:0000712)2.12862249
148Encephalitis (HP:0002383)2.12351118
149Osteomyelitis (HP:0002754)2.10085753
150Sepsis (HP:0100806)2.07222387
151Abnormal protein glycosylation (HP:0012346)2.06269840
152Abnormal glycosylation (HP:0012345)2.06269840
153Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.06269840
154Abnormal protein N-linked glycosylation (HP:0012347)2.06269840
155Occipital encephalocele (HP:0002085)2.05025750
156Spontaneous hematomas (HP:0007420)2.04407134
157Posterior subcapsular cataract (HP:0007787)2.03412605
158Inflammation of the large intestine (HP:0002037)2.01710114
159Recurrent lower respiratory tract infections (HP:0002783)2.01402540
160Abnormality of aspartate family amino acid metabolism (HP:0010899)2.01245781
161Cerebral hypomyelination (HP:0006808)2.00701133
162Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.00152010
163Fatigue (HP:0012378)1.99465804
164Arterial thrombosis (HP:0004420)1.98768181
165Skin ulcer (HP:0200042)1.97754331
166Prostate neoplasm (HP:0100787)1.96326148
167Atrophy/Degeneration involving motor neurons (HP:0007373)1.96220010
168Sclerocornea (HP:0000647)1.95530957
169Median cleft lip (HP:0000161)1.93023470
170IgA deficiency (HP:0002720)1.92429587
171Aplastic anemia (HP:0001915)1.92416151
172Postaxial foot polydactyly (HP:0001830)1.91624406
173Neutropenia (HP:0001875)1.89971936
174Keratoconjunctivitis sicca (HP:0001097)1.88669421
175Skin rash (HP:0000988)1.88191957
176Microcytic anemia (HP:0001935)1.88162304
177Increased hepatocellular lipid droplets (HP:0006565)1.87331897
178Abnormality of magnesium homeostasis (HP:0004921)1.84749410
179Hemiparesis (HP:0001269)1.81112852
180Broad foot (HP:0001769)1.80583432
181Hyperaldosteronism (HP:0000859)1.80234172
182Abnormality of the labia minora (HP:0012880)1.79951572
183Hypomagnesemia (HP:0002917)1.77329969
184Aplasia/Hypoplasia of the tongue (HP:0010295)1.77079109
185Abnormality of urine glucose concentration (HP:0011016)1.73544084
186Glycosuria (HP:0003076)1.73544084
187Postaxial hand polydactyly (HP:0001162)1.72990304
188Aplasia/hypoplasia of the uterus (HP:0008684)1.70227161
189Abolished electroretinogram (ERG) (HP:0000550)1.68914129
190Increased circulating renin level (HP:0000848)1.68304224
191Neoplasm of the adrenal gland (HP:0100631)1.68144514
192Delayed CNS myelination (HP:0002188)1.67519865

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.39640903
2TXK3.24667218
3NME23.16029506
4VRK23.03658725
5MAP3K143.03176857
6MST42.80982974
7BLK2.75526510
8JAK32.59310843
9TBK12.49836214
10IRAK42.46583453
11IKBKE2.43123860
12BUB12.41486775
13MAP4K22.41385451
14TEC2.38273796
15PIM22.28906449
16KDR2.19123141
17ZAP702.12647342
18TYK22.04716818
19SRPK11.98911375
20MAP3K121.98665357
21NEK11.97921134
22PDK21.92587960
23BCKDK1.90239455
24KIT1.88529015
25TRIM281.85007166
26BTK1.79671078
27TESK11.77990736
28IRAK31.75894734
29IKBKB1.75483041
30ZAK1.63716191
31CSNK1G31.63128922
32TESK21.58067665
33RIPK41.56585802
34NME11.49333293
35WNK31.48733028
36MYLK1.47709898
37CSNK1G21.47185495
38BCR1.46302551
39ACVR1B1.44084314
40EPHA41.40085093
41CSNK1G11.39023103
42JAK11.38618152
43PRKG21.38098216
44LRRK21.37603349
45SYK1.35905217
46CSK1.35144389
47LIMK11.33694401
48ITK1.33591705
49CCNB11.31569074
50CSNK1A1L1.30182818
51NLK1.27797842
52ERBB31.27339502
53CASK1.26792687
54LCK1.26407497
55STK101.23505163
56PLK31.18368159
57NEK91.17848986
58PINK11.17827498
59DYRK21.15063196
60EPHB11.13268362
61OXSR11.11695876
62TSSK61.10923626
63MKNK11.09283652
64TLK11.06963944
65NTRK21.06272097
66MATK1.05203622
67MAPK151.04317819
68LYN1.02598037
69TTK1.02471880
70ERN11.02353036
71PLK21.00984828
72DAPK10.98722907
73PIM10.95724057
74FGFR40.95172745
75TGFBR20.94985661
76GRK60.93707433
77STK390.90882155
78TRPM70.90805071
79RPS6KA40.89776265
80GRK10.89104416
81FES0.87956350
82FLT30.87558520
83CLK10.85894658
84PBK0.85208375
85MAP3K130.85137727
86MKNK20.84731594
87HCK0.84501116
88PIK3CG0.84064862
89CDC70.83475005
90CSF1R0.82507397
91ERBB40.81968241
92TAOK30.79671699
93SIK30.79012760
94MAPK130.78432837
95MINK10.78377151
96TNIK0.78327319
97TIE10.77973054
98STK160.77896561
99MAP2K20.77737312
100CHUK0.76247175
101EPHA30.73050356
102IRAK10.73038234
103MAP2K70.72626592
104ARAF0.72497285
105RPS6KA50.72042759
106CAMK2G0.71322253
107ADRBK20.71181299
108MAP2K30.70972156
109CDK80.70693889
110WEE10.68335545
111MARK10.68285969
112PIK3CA0.67554543
113MAP3K110.67120051
114* PLK10.67110760
115BRSK20.65598706
116CAMKK20.64352265
117PRKCQ0.63750347
118JAK20.63382832
119TGFBR10.62549180
120CAMK2D0.61926142
121MARK30.61529892
122MAP3K40.61355750
123EIF2AK30.60254787
124PRKCD0.60053591
125SCYL20.59957440
126PHKG10.59835857
127PHKG20.59835857
128MAPKAPK50.59368064
129CAMK2A0.59199318
130PKN10.59155024
131EIF2AK10.57658009
132FGFR30.56885997
133PLK40.53075206
134STK38L0.52628462
135MST1R0.51974832
136PRKCE0.51974128
137BMPR20.51346057
138MAPKAPK20.51303564
139CSNK1A10.50522275
140VRK10.49962672
141PAK60.49657463
142MET0.49369244
143YES10.47986572
144INSRR0.47907602
145UHMK10.47811534
146NEK60.47476072
147AURKB0.47255695
148MAP3K10.44983843
149ROCK20.44754094
150EPHA20.44276054
151CDK190.43990752
152CAMK2B0.43290931
153LMTK20.41963209
154NUAK10.41644081
155NTRK30.41466159
156FRK0.40743960
157CSNK2A10.40360584
158BRSK10.40228298
159MAP2K60.39126822
160EIF2AK20.38637885
161BMPR1B0.37729024
162ABL10.37528704
163MUSK0.35140643
164PAK40.35055274
165ILK0.34870168
166ABL20.33952623
167MAPK40.33876047
168MAPK110.32891758
169DAPK30.32541038
170MAP3K80.31932304

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.05143501
2Intestinal immune network for IgA production_Homo sapiens_hsa046722.63094010
3Leishmaniasis_Homo sapiens_hsa051402.62895492
4Allograft rejection_Homo sapiens_hsa053302.58274443
5Ribosome_Homo sapiens_hsa030102.54530602
6Graft-versus-host disease_Homo sapiens_hsa053322.54475584
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.41244874
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.39678124
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.20080121
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.18459544
11RNA polymerase_Homo sapiens_hsa030202.09666179
12Measles_Homo sapiens_hsa051622.05972674
13Propanoate metabolism_Homo sapiens_hsa006402.00939882
14Hematopoietic cell lineage_Homo sapiens_hsa046401.99102758
15Fatty acid elongation_Homo sapiens_hsa000621.88685749
16Mismatch repair_Homo sapiens_hsa034301.87569805
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.84643624
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82284114
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.79565423
20Antigen processing and presentation_Homo sapiens_hsa046121.73623980
21Osteoclast differentiation_Homo sapiens_hsa043801.71896580
22Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.71107224
23Pertussis_Homo sapiens_hsa051331.70438035
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.69736123
25Protein export_Homo sapiens_hsa030601.67171222
26Shigellosis_Homo sapiens_hsa051311.65621730
27Malaria_Homo sapiens_hsa051441.60816494
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.60607276
29Autoimmune thyroid disease_Homo sapiens_hsa053201.57719547
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57038975
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.56662430
32Legionellosis_Homo sapiens_hsa051341.51501618
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.51211797
34Asthma_Homo sapiens_hsa053101.50180192
35B cell receptor signaling pathway_Homo sapiens_hsa046621.50071536
36Salmonella infection_Homo sapiens_hsa051321.48852520
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.45146580
38Toxoplasmosis_Homo sapiens_hsa051451.42942534
39Nitrogen metabolism_Homo sapiens_hsa009101.42480382
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.41480939
41Pyruvate metabolism_Homo sapiens_hsa006201.40083110
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.40045792
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38809938
44Other glycan degradation_Homo sapiens_hsa005111.38738991
45T cell receptor signaling pathway_Homo sapiens_hsa046601.37438489
46Proteasome_Homo sapiens_hsa030501.37413881
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.36272192
48Rheumatoid arthritis_Homo sapiens_hsa053231.33601443
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.32763759
50Peroxisome_Homo sapiens_hsa041461.31455323
51Cardiac muscle contraction_Homo sapiens_hsa042601.31320904
52TNF signaling pathway_Homo sapiens_hsa046681.31258349
53Viral myocarditis_Homo sapiens_hsa054161.30707884
54Folate biosynthesis_Homo sapiens_hsa007901.30127603
55Tuberculosis_Homo sapiens_hsa051521.27870899
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27463831
57Influenza A_Homo sapiens_hsa051641.24781585
58Apoptosis_Homo sapiens_hsa042101.24209477
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23624924
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.22520757
61Herpes simplex infection_Homo sapiens_hsa051681.21870011
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21094329
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.20297840
64Chemical carcinogenesis_Homo sapiens_hsa052041.19089601
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17147606
66Butanoate metabolism_Homo sapiens_hsa006501.15403649
67Chemokine signaling pathway_Homo sapiens_hsa040621.13668228
68Type I diabetes mellitus_Homo sapiens_hsa049401.13302226
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13071200
70Fatty acid degradation_Homo sapiens_hsa000711.12076094
71Spliceosome_Homo sapiens_hsa030401.10656946
72Cysteine and methionine metabolism_Homo sapiens_hsa002701.10203180
73SNARE interactions in vesicular transport_Homo sapiens_hsa041301.08666181
74Oxidative phosphorylation_Homo sapiens_hsa001901.08612867
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03996151
76Nucleotide excision repair_Homo sapiens_hsa034201.03639698
77Parkinsons disease_Homo sapiens_hsa050121.03277312
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03195094
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01932623
80Sulfur metabolism_Homo sapiens_hsa009201.01743948
81Fatty acid metabolism_Homo sapiens_hsa012120.99011741
82Purine metabolism_Homo sapiens_hsa002300.98949596
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98920753
84beta-Alanine metabolism_Homo sapiens_hsa004100.98792700
85Hepatitis B_Homo sapiens_hsa051610.98657072
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98470344
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97349259
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97323634
89Acute myeloid leukemia_Homo sapiens_hsa052210.95808300
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95396902
91Non-homologous end-joining_Homo sapiens_hsa034500.94666556
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94578599
93Platelet activation_Homo sapiens_hsa046110.92699693
94Histidine metabolism_Homo sapiens_hsa003400.92186417
95Hepatitis C_Homo sapiens_hsa051600.90939661
96Tryptophan metabolism_Homo sapiens_hsa003800.90564691
97RNA degradation_Homo sapiens_hsa030180.90231513
98Fat digestion and absorption_Homo sapiens_hsa049750.89660050
99Carbon metabolism_Homo sapiens_hsa012000.87202678
100Phagosome_Homo sapiens_hsa041450.87053488
101Metabolic pathways_Homo sapiens_hsa011000.85762111
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82540938
103Steroid biosynthesis_Homo sapiens_hsa001000.81456374
104African trypanosomiasis_Homo sapiens_hsa051430.81349105
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.80800995
106Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78971513
107Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77945178
108Arginine and proline metabolism_Homo sapiens_hsa003300.77762478
109Collecting duct acid secretion_Homo sapiens_hsa049660.77500434
110Fanconi anemia pathway_Homo sapiens_hsa034600.77082755
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76467675
112Retinol metabolism_Homo sapiens_hsa008300.76440463
113Lysosome_Homo sapiens_hsa041420.76007056
114Basal transcription factors_Homo sapiens_hsa030220.75570474
115DNA replication_Homo sapiens_hsa030300.74581404
116Thyroid cancer_Homo sapiens_hsa052160.74432728
117Alzheimers disease_Homo sapiens_hsa050100.72770838
118One carbon pool by folate_Homo sapiens_hsa006700.72667340
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.72660800
120Cyanoamino acid metabolism_Homo sapiens_hsa004600.71323548
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68448390
122Nicotine addiction_Homo sapiens_hsa050330.67853818
123Linoleic acid metabolism_Homo sapiens_hsa005910.64381540
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62600011
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62121404
126Biosynthesis of amino acids_Homo sapiens_hsa012300.61685697
127Staphylococcus aureus infection_Homo sapiens_hsa051500.60242841
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59991149
129Mineral absorption_Homo sapiens_hsa049780.57825967
130Prolactin signaling pathway_Homo sapiens_hsa049170.57751427
131Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56221413
132Vitamin digestion and absorption_Homo sapiens_hsa049770.55477646
133Steroid hormone biosynthesis_Homo sapiens_hsa001400.55217541
134Arachidonic acid metabolism_Homo sapiens_hsa005900.55031053
135Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54517029
136Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53529568
137Epstein-Barr virus infection_Homo sapiens_hsa051690.50320417
138p53 signaling pathway_Homo sapiens_hsa041150.49150986
139Vitamin B6 metabolism_Homo sapiens_hsa007500.48868820
140RNA transport_Homo sapiens_hsa030130.47986853
141alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47854439
142Pancreatic cancer_Homo sapiens_hsa052120.47539654
143Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46795006
144N-Glycan biosynthesis_Homo sapiens_hsa005100.46561508
145Phototransduction_Homo sapiens_hsa047440.45737784
146Galactose metabolism_Homo sapiens_hsa000520.45363766
147Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44096931
148Sphingolipid metabolism_Homo sapiens_hsa006000.43675404
149Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42334300
150Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41334570
151Sulfur relay system_Homo sapiens_hsa041220.40535547
152Tyrosine metabolism_Homo sapiens_hsa003500.40271653
153Caffeine metabolism_Homo sapiens_hsa002320.38907660
154Viral carcinogenesis_Homo sapiens_hsa052030.38520692
155Renin-angiotensin system_Homo sapiens_hsa046140.38249398
156Pancreatic secretion_Homo sapiens_hsa049720.37712975
157Glycosaminoglycan degradation_Homo sapiens_hsa005310.37667962
158Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37234776
159Base excision repair_Homo sapiens_hsa034100.36816892
160Chronic myeloid leukemia_Homo sapiens_hsa052200.36163729
161Pyrimidine metabolism_Homo sapiens_hsa002400.35560480
162Glutathione metabolism_Homo sapiens_hsa004800.35313286
163Homologous recombination_Homo sapiens_hsa034400.35312544
164Huntingtons disease_Homo sapiens_hsa050160.34695538
165Oocyte meiosis_Homo sapiens_hsa041140.34457911
166Small cell lung cancer_Homo sapiens_hsa052220.33467182
167Sphingolipid signaling pathway_Homo sapiens_hsa040710.33007733
168Vibrio cholerae infection_Homo sapiens_hsa051100.31266686
169PPAR signaling pathway_Homo sapiens_hsa033200.30923263

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