SRL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)9.23385170
2actin-myosin filament sliding (GO:0033275)9.23385170
3sarcomere organization (GO:0045214)9.01927234
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)8.38130608
5cardiac myofibril assembly (GO:0055003)7.96544641
6myofibril assembly (GO:0030239)7.75780027
7actin-mediated cell contraction (GO:0070252)7.63614111
8regulation of skeletal muscle contraction (GO:0014819)7.62745233
9negative regulation of potassium ion transmembrane transport (GO:1901380)7.37068848
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)7.07479454
11regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.81405105
12sarcoplasmic reticulum calcium ion transport (GO:0070296)6.73615566
13plasma membrane repair (GO:0001778)6.73392111
14cardiac muscle contraction (GO:0060048)6.47092467
15regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.18998763
16tricarboxylic acid cycle (GO:0006099)6.08757722
17striated muscle contraction (GO:0006941)6.06392168
18cardiac muscle cell development (GO:0055013)6.05760685
19regulation of relaxation of muscle (GO:1901077)5.91408403
20actomyosin structure organization (GO:0031032)5.87316801
21skeletal muscle contraction (GO:0003009)5.74498527
22actin filament-based movement (GO:0030048)5.72963168
23cardiac cell development (GO:0055006)5.68741198
24regulation of actin filament-based movement (GO:1903115)5.65850004
25regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.59940038
26regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.56355388
27carnitine shuttle (GO:0006853)5.54072293
28regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.53714449
29regulation of cell communication by electrical coupling (GO:0010649)5.48305006
30regulation of sarcomere organization (GO:0060297)5.46547660
31regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.44453998
32ventricular cardiac muscle cell action potential (GO:0086005)5.24872191
33cardiac muscle hypertrophy (GO:0003300)5.17999132
34cardiac muscle tissue morphogenesis (GO:0055008)5.15274646
35adult heart development (GO:0007512)5.07567326
36regulation of acyl-CoA biosynthetic process (GO:0050812)5.05751877
37response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.01284557
38striated muscle hypertrophy (GO:0014897)5.00297187
39regulation of striated muscle contraction (GO:0006942)4.92942156
40skeletal muscle fiber development (GO:0048741)4.90234348
41fatty acid transmembrane transport (GO:1902001)4.77181939
42heart process (GO:0003015)4.74460889
43heart contraction (GO:0060047)4.74460889
44muscle tissue morphogenesis (GO:0060415)4.73980319
45regulation of membrane repolarization (GO:0060306)4.70521854
46heart trabecula formation (GO:0060347)4.69066257
47ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.66293951
48bundle of His cell to Purkinje myocyte communication (GO:0086069)4.63464833
49regulation of cofactor metabolic process (GO:0051193)4.62204178
50regulation of coenzyme metabolic process (GO:0051196)4.62204178
51myotube cell development (GO:0014904)4.58731066
52muscle hypertrophy (GO:0014896)4.41223019
53skeletal muscle adaptation (GO:0043501)4.40577209
54muscle contraction (GO:0006936)4.26410888
55creatine metabolic process (GO:0006600)4.22293856
56response to inactivity (GO:0014854)4.17717002
57cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.16028755
58cell communication involved in cardiac conduction (GO:0086065)4.14792500
59skeletal muscle tissue development (GO:0007519)4.12166030
60regulation of the force of heart contraction (GO:0002026)4.09425342
61carnitine transmembrane transport (GO:1902603)4.06045998
62striated muscle cell development (GO:0055002)4.04174684
63striated muscle adaptation (GO:0014888)4.03553173
64muscle system process (GO:0003012)3.94638488
65negative regulation of potassium ion transport (GO:0043267)3.93281170
66muscle cell cellular homeostasis (GO:0046716)3.87781070
67cardiac muscle hypertrophy in response to stress (GO:0014898)3.85765479
68muscle hypertrophy in response to stress (GO:0003299)3.85765479
69cardiac muscle adaptation (GO:0014887)3.85765479
70negative regulation of protein localization to cell surface (GO:2000009)3.82606139
71positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.82127057
72cardiac muscle cell action potential involved in contraction (GO:0086002)3.80486321
73cardiac muscle cell action potential (GO:0086001)3.79797659
74glycogen biosynthetic process (GO:0005978)3.76709821
75glucan biosynthetic process (GO:0009250)3.76709821
76regulation of sulfur metabolic process (GO:0042762)3.76589243
77regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.75843468
78mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.75829405
79muscle cell fate commitment (GO:0042693)3.74527431
80regulation of cardiac muscle contraction (GO:0055117)3.72800279
81positive regulation of myotube differentiation (GO:0010831)3.71061859
82amino-acid betaine transport (GO:0015838)3.68556445
83carnitine transport (GO:0015879)3.68556445
84regulation of heart rate (GO:0002027)3.67643631
85striated muscle atrophy (GO:0014891)3.64341475
86negative regulation of calcium ion transmembrane transport (GO:1903170)3.63798073
87negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.63798073
88response to muscle activity (GO:0014850)3.63219451
89muscle organ development (GO:0007517)3.62910163
90muscle structure development (GO:0061061)3.62172776
91membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.60846877
92regulation of calcium ion transmembrane transporter activity (GO:1901019)3.59609097
93regulation of calcium ion transmembrane transport (GO:1903169)3.59609097
94regulation of ATPase activity (GO:0043462)3.59283030
95regulation of ATP catabolic process (GO:1903289)3.59283030
96regulation of muscle system process (GO:0090257)3.59169465
97cell communication by electrical coupling (GO:0010644)3.59104035
98muscle fiber development (GO:0048747)3.58864463
99glucan catabolic process (GO:0009251)3.58709214
100negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.56928408
101skeletal muscle tissue regeneration (GO:0043403)3.54163357
102glycogen catabolic process (GO:0005980)3.53813704
103oxidative phosphorylation (GO:0006119)3.53678405
104response to caffeine (GO:0031000)3.50561159
105regulation of cardiac muscle cell contraction (GO:0086004)3.49922547
1062-oxoglutarate metabolic process (GO:0006103)3.49891143
107NADH metabolic process (GO:0006734)3.49257108
108muscle cell development (GO:0055001)3.48326200
109ATP synthesis coupled proton transport (GO:0015986)3.45655421
110energy coupled proton transport, down electrochemical gradient (GO:0015985)3.45655421
111regulation of myoblast differentiation (GO:0045661)3.45052163
112relaxation of cardiac muscle (GO:0055119)3.43982358
113mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.41992348
114respiratory electron transport chain (GO:0022904)3.38549502
115muscle atrophy (GO:0014889)3.37028581
116positive regulation of myoblast differentiation (GO:0045663)3.36813460
117muscle adaptation (GO:0043500)3.36022858
118regulation of muscle contraction (GO:0006937)3.35841339
119regulation of sequestering of triglyceride (GO:0010889)3.35488619
120negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.34810161
121pyrimidine ribonucleoside catabolic process (GO:0046133)3.34756197
122cellular polysaccharide catabolic process (GO:0044247)3.34749321
123regulation of heart contraction (GO:0008016)3.29972385
124positive regulation of cation channel activity (GO:2001259)3.29971703

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.53090950
2EP300_21415370_ChIP-Seq_HL-1_Mouse4.81212279
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.37422977
4TBX20_22328084_ChIP-Seq_HEART_Mouse4.23558594
5TBX20_22080862_ChIP-Seq_HEART_Mouse4.23558594
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.03060685
7ESR1_20079471_ChIP-ChIP_T-47D_Human3.67926729
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.61586703
9MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.48620370
10ZNF263_19887448_ChIP-Seq_K562_Human3.44049288
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.38098809
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.29151150
13CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.78153206
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.68859691
15* GATA4_21415370_ChIP-Seq_HL-1_Mouse2.45138831
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34681621
17EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.22182266
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.17739479
19EZH2_22144423_ChIP-Seq_EOC_Human2.13926457
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.93511134
21ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.91711492
22* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.89421250
23CLOCK_20551151_ChIP-Seq_293T_Human1.85513828
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.84135747
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78640421
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.68741884
27PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.67477712
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.56116335
29VDR_22108803_ChIP-Seq_LS180_Human1.52749059
30BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.47244798
31* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.44078039
32ZNF274_21170338_ChIP-Seq_K562_Hela1.43010801
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.40513163
34ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.38885633
35NFIB_24661679_ChIP-Seq_LUNG_Mouse1.38715914
36NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.38153206
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35257871
38BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33672891
39EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31385170
40RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.30852603
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30691092
42GBX2_23144817_ChIP-Seq_PC3_Human1.29871472
43CTCF_27219007_Chip-Seq_Bcells_Human1.26351291
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23392300
45ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23065562
46PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22464533
47GATA1_22025678_ChIP-Seq_K562_Human1.22283886
48IGF1R_20145208_ChIP-Seq_DFB_Human1.21760573
49* KDM2B_26808549_Chip-Seq_DND41_Human1.21276957
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19991670
51ISL1_27105846_Chip-Seq_CPCs_Mouse1.19909321
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17064010
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.16150685
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13986422
55PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12925613
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.11386289
57ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10559379
58KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09955823
59HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09799981
60SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09769872
61DROSHA_22980978_ChIP-Seq_HELA_Human1.09377665
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08462166
63ATF3_27146783_Chip-Seq_COLON_Human1.07743181
64TP63_22573176_ChIP-Seq_HFKS_Human1.06947061
65ESR1_21235772_ChIP-Seq_MCF-7_Human1.06926125
66RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05417735
67EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05417735
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04906751
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04610932
70SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04602833
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04320345
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.03869136
73MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02977296
74PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01327677
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.00300145
76SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.99912245
77SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99578118
78TRIM28_21343339_ChIP-Seq_HEK293_Human0.99412646
79CJUN_26792858_Chip-Seq_BT549_Human0.99227564
80GATA1_19941826_ChIP-Seq_K562_Human0.98625728
81SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98620173
82CRX_20693478_ChIP-Seq_RETINA_Mouse0.97790243
83SMC3_22415368_ChIP-Seq_MEFs_Mouse0.97424445
84SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96682173
85SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.94172487
86* RACK7_27058665_Chip-Seq_MCF-7_Human0.93537100
87* RUNX1_27514584_Chip-Seq_MCF-7_Human0.93001738
88AR_21572438_ChIP-Seq_LNCaP_Human0.92311783
89PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91648674
90STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90449619
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90370021
92CTCF_21964334_ChIP-Seq_BJAB-B_Human0.90274021
93LXR_22158963_ChIP-Seq_LIVER_Mouse0.89826037
94AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89042819
95OCT4_21477851_ChIP-Seq_ESCs_Mouse0.88701886
96JARID2_20075857_ChIP-Seq_MESCs_Mouse0.88118882
97SPI1_20517297_ChIP-Seq_HL60_Human0.87901567
98GATA2_21666600_ChIP-Seq_HMVEC_Human0.87742957
99CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87738741
100RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87688472
101RARB_27405468_Chip-Seq_BRAIN_Mouse0.87563633
102* FOXH1_21741376_ChIP-Seq_ESCs_Human0.86936116
103OCT4_20526341_ChIP-Seq_ESCs_Human0.86744008
104SMAD4_21799915_ChIP-Seq_A2780_Human0.86270993
105WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.86262255
106FLI1_27457419_Chip-Seq_LIVER_Mouse0.86240102
107UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85740048
108CTCF_21964334_Chip-Seq_Bcells_Human0.84979930
109NR3C1_23031785_ChIP-Seq_PC12_Mouse0.84878290
110SOX2_21211035_ChIP-Seq_LN229_Gbm0.84189361
111EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83811446
112* SMAD3_21741376_ChIP-Seq_HESCs_Human0.83721099
113WT1_19549856_ChIP-ChIP_CCG9911_Human0.83694721
114ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.83435517
115FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.83418932
116LXR_22292898_ChIP-Seq_THP-1_Human0.83279919
117MYC_27129775_Chip-Seq_CORNEA_Mouse0.82505200
118SMC1_22415368_ChIP-Seq_MEFs_Mouse0.81995537
119NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81781681
120NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81781681
121STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.81536384
122SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.80969122
123GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.79789841
124P300_27058665_Chip-Seq_ZR-75-30cells_Human0.79379529
125TP53_23651856_ChIP-Seq_MEFs_Mouse0.78712423
126NR3C1_21868756_ChIP-Seq_MCF10A_Human0.78682401
127DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.78478510
128FOXA2_19822575_ChIP-Seq_HepG2_Human0.78463408
129TDRD3_21172665_ChIP-Seq_MCF-7_Human0.78167999
130NFE2_27457419_Chip-Seq_LIVER_Mouse0.77913384
131* P68_20966046_ChIP-Seq_HELA_Human0.77460972
132GATA1_19941827_ChIP-Seq_MEL86_Mouse0.77296687
133HTT_18923047_ChIP-ChIP_STHdh_Human0.77015288
134CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.76681478
135TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.76544492
136GATA2_19941826_ChIP-Seq_K562_Human0.76164080
137GF1_26923725_Chip-Seq_HPCs_Mouse0.75627777
138P63_26484246_Chip-Seq_KERATINOCYTES_Human0.75527905
139FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.74698087
140* SMAD4_21741376_ChIP-Seq_HESCs_Human0.74322132
141RNF2_27304074_Chip-Seq_ESCs_Mouse0.74256796
142SUZ12_27294783_Chip-Seq_ESCs_Mouse0.74224687
143TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73734464
144* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.73110468
145CREB1_26743006_Chip-Seq_LNCaP_Human0.72936064
146BCAT_22108803_ChIP-Seq_LS180_Human0.72523816
147WT1_25993318_ChIP-Seq_PODOCYTE_Human0.72467435
148MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.72451125
149PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.72436732
150E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.71662850
151YY1_22570637_ChIP-Seq_MALME-3M_Human0.71476061
152DNAJC2_21179169_ChIP-ChIP_NT2_Human0.69095495
153GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.68986485

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.16978356
2MP0003646_muscle_fatigue5.64764760
3MP0000751_myopathy5.56810663
4MP0000749_muscle_degeneration4.82811079
5* MP0004084_abnormal_cardiac_muscle4.72054382
6MP0004215_abnormal_myocardial_fiber4.33220717
7* MP0004036_abnormal_muscle_relaxation4.15306664
8MP0004145_abnormal_muscle_electrophysio3.98104987
9MP0005330_cardiomyopathy3.76041186
10* MP0004087_abnormal_muscle_fiber3.39138701
11MP0000750_abnormal_muscle_regeneration3.16488455
12* MP0002106_abnormal_muscle_physiology3.10798626
13* MP0005620_abnormal_muscle_contractility2.97565200
14* MP0002972_abnormal_cardiac_muscle2.86416631
15MP0004130_abnormal_muscle_cell2.79693326
16MP0000747_muscle_weakness2.79205878
17MP0002269_muscular_atrophy2.77071432
18MP0008775_abnormal_heart_ventricle2.63819442
19MP0003137_abnormal_impulse_conducting2.61364937
20MP0000759_abnormal_skeletal_muscle2.59821389
21* MP0005369_muscle_phenotype2.52359215
22MP0010630_abnormal_cardiac_muscle2.52083235
23MP0004484_altered_response_of2.35814755
24* MP0001544_abnormal_cardiovascular_syste2.27404864
25* MP0005385_cardiovascular_system_phenoty2.27404864
26MP0004233_abnormal_muscle_weight2.12730048
27MP0006138_congestive_heart_failure2.09441609
28MP0003828_pulmonary_edema1.99123188
29MP0003221_abnormal_cardiomyocyte_apopto1.91421730
30MP0004085_abnormal_heartbeat1.81429473
31MP0006036_abnormal_mitochondrial_physio1.75807105
32MP0003950_abnormal_plasma_membrane1.72961044
33MP0004510_myositis1.67184319
34MP0002332_abnormal_exercise_endurance1.62401086
35MP0002127_abnormal_cardiovascular_syste1.57685573
36MP0000733_abnormal_muscle_development1.38674491
37MP0003567_abnormal_fetal_cardiomyocyte1.36238776
38MP0005666_abnormal_adipose_tissue1.35523682
39MP0002108_abnormal_muscle_morphology1.23459273
40MP0002234_abnormal_pharynx_morphology1.13436842
41MP0000266_abnormal_heart_morphology1.12208035
42MP0004185_abnormal_adipocyte_glucose1.10801252
43MP0006035_abnormal_mitochondrial_morpho1.05448140
44MP0000343_altered_response_to1.00654682
45MP0001661_extended_life_span0.99011625
46MP0005375_adipose_tissue_phenotype0.94742699
47MP0005670_abnormal_white_adipose0.90481334
48MP0003279_aneurysm0.88763129
49MP0005266_abnormal_metabolism0.87064791
50MP0005165_increased_susceptibility_to0.84835117
51MP0003705_abnormal_hypodermis_morpholog0.84457520
52MP0010368_abnormal_lymphatic_system0.80790253
53MP0002971_abnormal_brown_adipose0.80236766
54MP0002128_abnormal_blood_circulation0.72603692
55MP0005623_abnormal_meninges_morphology0.72000053
56MP0003566_abnormal_cell_adhesion0.68092444
57MP0005275_abnormal_skin_tensile0.67910147
58MP0000013_abnormal_adipose_tissue0.66393866
59MP0000230_abnormal_systemic_arterial0.61518376
60MP0003806_abnormal_nucleotide_metabolis0.61430504
61MP0004272_abnormal_basement_membrane0.61109514
62MP0002822_catalepsy0.61059182
63MP0000003_abnormal_adipose_tissue0.60153057
64MP0005451_abnormal_body_composition0.59400889
65MP0008438_abnormal_cutaneous_collagen0.56973272
66MP0000767_abnormal_smooth_muscle0.52660379
67MP0000372_irregular_coat_pigmentation0.49334556
68MP0004043_abnormal_pH_regulation0.49173821
69MP0001879_abnormal_lymphatic_vessel0.48556877
70MP0004147_increased_porphyrin_level0.46578424
71MP0002925_abnormal_cardiovascular_devel0.45978780
72MP0002078_abnormal_glucose_homeostasis0.45722006
73MP0002638_abnormal_pupillary_reflex0.44997299
74MP0008961_abnormal_basal_metabolism0.44831579
75MP0005187_abnormal_penis_morphology0.42910643
76MP0008569_lethality_at_weaning0.41678784
77MP0005319_abnormal_enzyme/_coenzyme0.39016698
78MP0001784_abnormal_fluid_regulation0.38108838
79MP0003984_embryonic_growth_retardation0.37609449
80MP0002088_abnormal_embryonic_growth/wei0.37030985
81MP0004134_abnormal_chest_morphology0.36497351
82MP0009384_cardiac_valve_regurgitation0.35987598
83MP0005167_abnormal_blood-brain_barrier0.35709065
84MP0003948_abnormal_gas_homeostasis0.35325100
85MP0002909_abnormal_adrenal_gland0.35226118
86MP0003879_abnormal_hair_cell0.34742253
87MP0001614_abnormal_blood_vessel0.34398936
88MP0010030_abnormal_orbit_morphology0.31962376
89MP0006276_abnormal_autonomic_nervous0.31695952
90MP0005334_abnormal_fat_pad0.29078834
91MP0004142_abnormal_muscle_tone0.28126765
92MP0001299_abnormal_eye_distance/0.27924403
93MP0005376_homeostasis/metabolism_phenot0.27296912
94MP0001984_abnormal_olfaction0.27237593
95MP0009780_abnormal_chondrocyte_physiolo0.24815115
96MP0002114_abnormal_axial_skeleton0.24690870
97MP0003045_fibrosis0.24514594
98MP0003656_abnormal_erythrocyte_physiolo0.24366987
99MP0002734_abnormal_mechanical_nocicepti0.24066624
100MP0009115_abnormal_fat_cell0.23717451
101MP0005452_abnormal_adipose_tissue0.23414927
102MP0009250_abnormal_appendicular_skeleto0.23195714
103MP0005423_abnormal_somatic_nervous0.22673932
104MP0009672_abnormal_birth_weight0.21631805
105MP0005535_abnormal_body_temperature0.21588700
106MP0001943_abnormal_respiration0.21546207
107MP0003941_abnormal_skin_development0.21454022
108MP0005503_abnormal_tendon_morphology0.20609979
109MP0004924_abnormal_behavior0.20080258
110MP0005386_behavior/neurological_phenoty0.20080258
111MP0002249_abnormal_larynx_morphology0.18687977
112MP0001672_abnormal_embryogenesis/_devel0.18505975
113MP0005380_embryogenesis_phenotype0.18505975
114MP0002896_abnormal_bone_mineralization0.18335459
115MP0002877_abnormal_melanocyte_morpholog0.18258196
116MP0001727_abnormal_embryo_implantation0.17998886
117MP0005584_abnormal_enzyme/coenzyme_acti0.17595433
118MP0000762_abnormal_tongue_morphology0.17435447
119MP0004270_analgesia0.16594550
120MP0000579_abnormal_nail_morphology0.15988095
121MP0004197_abnormal_fetal_growth/weight/0.15762463
122MP0003385_abnormal_body_wall0.15362419

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.15878762
2Exercise-induced myalgia (HP:0003738)7.11916834
3Exercise-induced muscle cramps (HP:0003710)6.90932691
4Calf muscle hypertrophy (HP:0008981)6.65345783
5Muscle hypertrophy of the lower extremities (HP:0008968)6.50172000
6Muscle fiber splitting (HP:0003555)5.98099956
7Muscle fiber inclusion bodies (HP:0100299)5.74613095
8Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.67934963
9Ventricular tachycardia (HP:0004756)5.63709580
10Abnormality of the calf musculature (HP:0001430)5.44552110
11Subaortic stenosis (HP:0001682)5.24248962
12Abnormality of the left ventricular outflow tract (HP:0011103)5.24248962
13Hyporeflexia of lower limbs (HP:0002600)5.22674525
14Type 1 muscle fiber predominance (HP:0003803)5.17126650
15Myoglobinuria (HP:0002913)5.11639425
16Nemaline bodies (HP:0003798)5.03035040
17EMG: myopathic abnormalities (HP:0003458)4.71906980
18Atrial fibrillation (HP:0005110)4.68535362
19Difficulty running (HP:0009046)4.43650803
20Lipoatrophy (HP:0100578)4.43618196
21Increased connective tissue (HP:0009025)4.39353237
22Primary atrial arrhythmia (HP:0001692)4.38149865
23Supraventricular tachycardia (HP:0004755)4.23205037
24Supraventricular arrhythmia (HP:0005115)4.15396959
25Distal arthrogryposis (HP:0005684)4.14199799
26Right ventricular cardiomyopathy (HP:0011663)4.12758827
27Rhabdomyolysis (HP:0003201)4.06100962
28Asymmetric septal hypertrophy (HP:0001670)4.01017987
29Syncope (HP:0001279)3.85984837
30Dilated cardiomyopathy (HP:0001644)3.76746727
31Myotonia (HP:0002486)3.76009854
32Bundle branch block (HP:0011710)3.63287590
33Prolonged QT interval (HP:0001657)3.56622097
34Palpitations (HP:0001962)3.51634886
35Round ear (HP:0100830)3.47914985
36Ventricular arrhythmia (HP:0004308)3.47855946
37Difficulty climbing stairs (HP:0003551)3.37791030
38Myopathic facies (HP:0002058)3.31886987
39Muscle stiffness (HP:0003552)3.29656246
40Neck muscle weakness (HP:0000467)3.18114652
41Abnormality of skeletal muscle fiber size (HP:0012084)3.13151168
42Increased variability in muscle fiber diameter (HP:0003557)3.04869449
43Fetal akinesia sequence (HP:0001989)3.04869411
44Heart block (HP:0012722)3.03116902
45Ventricular fibrillation (HP:0001663)2.95667735
46Ulnar deviation of the wrist (HP:0003049)2.95461271
47Abnormal atrioventricular conduction (HP:0005150)2.86994089
48Atrioventricular block (HP:0001678)2.85152277
49Areflexia of lower limbs (HP:0002522)2.72883524
50Rimmed vacuoles (HP:0003805)2.70368454
51Mildly elevated creatine phosphokinase (HP:0008180)2.59628140
52Abnormal EKG (HP:0003115)2.56126460
53Distal lower limb muscle weakness (HP:0009053)2.52932917
54EMG: neuropathic changes (HP:0003445)2.52050304
55Generalized muscle weakness (HP:0003324)2.47394596
56Left ventricular hypertrophy (HP:0001712)2.44245669
57Calcaneovalgus deformity (HP:0001848)2.40737599
58Abnormality of the calcaneus (HP:0008364)2.38332779
59Hypoplastic ischia (HP:0003175)2.36787631
60Gowers sign (HP:0003391)2.35677410
61Popliteal pterygium (HP:0009756)2.34374383
62Centrally nucleated skeletal muscle fibers (HP:0003687)2.33958348
63Limb-girdle muscle atrophy (HP:0003797)2.33743523
64Frequent falls (HP:0002359)2.25059032
65Abnormal mitochondria in muscle tissue (HP:0008316)2.23979224
66Scapular winging (HP:0003691)2.23656958
67Absent phalangeal crease (HP:0006109)2.22168378
68Hepatic necrosis (HP:0002605)2.18293199
69Deformed tarsal bones (HP:0008119)2.16496826
70Palmoplantar keratoderma (HP:0000982)2.16164482
71Acute necrotizing encephalopathy (HP:0006965)2.15755688
72Muscular dystrophy (HP:0003560)2.15409819
73Distal lower limb amyotrophy (HP:0008944)2.13043884
74Malignant hyperthermia (HP:0002047)2.10509440
75Facial diplegia (HP:0001349)2.07677762
76Ketoacidosis (HP:0001993)2.07191342
77Abnormality of the ischium (HP:0003174)2.05376426
78Ragged-red muscle fibers (HP:0003200)2.04438973
79Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.01315412
80Slender build (HP:0001533)1.98285559
81Abnormality of the shoulder girdle musculature (HP:0001435)1.96833251
82Conjunctival hamartoma (HP:0100780)1.95966990
83Abnormality of the foot musculature (HP:0001436)1.94340308
84Hyperkalemia (HP:0002153)1.94136208
85Respiratory insufficiency due to muscle weakness (HP:0002747)1.94064162
86Fatigable weakness (HP:0003473)1.94016382
87Abnormality of the neuromuscular junction (HP:0003398)1.94016382
88Progressive muscle weakness (HP:0003323)1.93770588
89Waddling gait (HP:0002515)1.93524165
90Proximal amyotrophy (HP:0007126)1.93440902
91Hypoglycemic coma (HP:0001325)1.92295224
92Type 2 muscle fiber atrophy (HP:0003554)1.91854034
93Lower limb amyotrophy (HP:0007210)1.89070685
94Spinal rigidity (HP:0003306)1.88490093
95Exercise intolerance (HP:0003546)1.87329533
96Hepatocellular necrosis (HP:0001404)1.86291748
97Bulbar palsy (HP:0001283)1.85202962
98Limb-girdle muscle weakness (HP:0003325)1.84879423
99Hip contracture (HP:0003273)1.84012541
100Increased muscle lipid content (HP:0009058)1.83664675
101Metatarsus adductus (HP:0001840)1.83108250
102Acute encephalopathy (HP:0006846)1.82679879
103Weak cry (HP:0001612)1.80507608
104Foot dorsiflexor weakness (HP:0009027)1.80438208
105Testicular atrophy (HP:0000029)1.79891965
106Aplasia of the musculature (HP:0100854)1.79590806
107Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79083247
108Abnormality of alanine metabolism (HP:0010916)1.79083247
109Hyperalaninemia (HP:0003348)1.79083247
110Abnormal finger flexion creases (HP:0006143)1.78061491
111Progressive macrocephaly (HP:0004481)1.77948359
112Sudden cardiac death (HP:0001645)1.76499870
113Muscle fiber atrophy (HP:0100295)1.72605616
114Limited hip movement (HP:0008800)1.66410130
115Amniotic constriction ring (HP:0009775)1.65261694
116Abnormality of placental membranes (HP:0011409)1.65261694
117Steppage gait (HP:0003376)1.64752006
118Long clavicles (HP:0000890)1.61182751
119Increased intramyocellular lipid droplets (HP:0012240)1.55237952

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.43133084
2TTN5.89043263
3PHKG14.54638970
4PHKG24.54638970
5PDK43.33883506
6PDK33.33883506
7PKN23.01515119
8DMPK2.94046025
9TRIB32.82293599
10LMTK22.69713400
11NEK12.68307317
12MYLK2.62525602
13STK242.25907858
14MUSK2.22603857
15PIK3CA2.14522774
16PDK22.01524107
17BCKDK1.90954631
18PINK11.82918822
19TIE11.73090315
20PIK3CG1.52381776
21MAP3K71.48257299
22MARK11.42817292
23NME11.40239631
24MAP2K31.38079495
25ILK1.30202343
26MAPK121.24569972
27GRK71.22571100
28ZAK1.05253480
29PRKD10.97637536
30CAMK2D0.94752780
31CCNB10.92299372
32PAK30.91424016
33PRKAA10.91231732
34TRPM70.90420709
35MAPKAPK30.90310611
36ROCK10.87697256
37PRKAA20.87488106
38MOS0.86789326
39RIPK10.79285616
40MAP3K50.78821031
41FLT30.78414202
42CDC42BPA0.78374478
43STK38L0.75539583
44INSRR0.73085005
45MAP3K30.68028065
46STK40.65224345
47NEK90.64457387
48ERBB30.62777354
49PDGFRA0.62530294
50MAPK40.58587799
51WNK40.57428158
52CAMK40.54396600
53EPHA30.53468694
54AKT20.53274198
55DYRK1B0.52179858
56CAMK2B0.51758412
57PKN10.51736600
58DAPK30.50813835
59ROCK20.49396955
60EPHB10.49339895
61SIK10.48719174
62MAP2K40.47643047
63PTK60.47079989
64STK380.45528328
65PRKACB0.45428526
66TGFBR20.44828502
67MAP3K100.43710838
68CAMK2A0.42691099
69LATS10.41935419
70WNK10.41354014
71KSR20.38897612
72ICK0.38512120
73PTK2B0.38389439
74CAMK2G0.37640193
75MAP2K60.36103006
76MAP3K60.35677949
77KDR0.34007271
78CAMK10.33852737
79PRKACA0.33147097
80RPS6KC10.32005407
81RPS6KL10.32005407
82PDPK10.31194118
83MAPK110.29907177
84PRKACG0.29773679
85LIMK10.29407712
86LATS20.28784282
87PDK10.28293838
88MAP3K130.27320245
89SGK20.27291742
90MTOR0.26525745
91RPS6KA60.24768783
92MAPK130.22968463
93RPS6KA10.22839271
94PRKG10.22305199
95MAPK100.21485483
96STK390.21442650
97RET0.20325257
98RPS6KA30.19110065
99STK110.18081509
100SGK10.17879682
101NLK0.17508165
102PRKCE0.17450870
103LRRK20.16764166
104MAPK70.16452976
105EEF2K0.15653495
106RPS6KB20.14811272
107MARK20.13761109
108RPS6KB10.13626522
109FER0.13237481
110SGK4940.12371426
111SGK2230.12371426
112TBK10.12235745
113SGK30.11705880
114DAPK20.11649078
115PRKCH0.10473849
116MAP2K10.10409717
117EPHB20.10356400
118FGFR10.10263180
119TAOK10.10204875
120ZAP700.09885414
121MAP3K110.09527547
122MAP3K10.09255620
123PAK60.08382304
124KSR10.08183920
125PRKD30.08038616
126TAOK20.06921081
127DDR20.06439260

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.89680003
2Cardiac muscle contraction_Homo sapiens_hsa042604.35736152
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.24870609
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.11184810
5Dilated cardiomyopathy_Homo sapiens_hsa054144.02458738
6Propanoate metabolism_Homo sapiens_hsa006403.03095143
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.01737924
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.96895849
9Parkinsons disease_Homo sapiens_hsa050122.78486207
10Fatty acid degradation_Homo sapiens_hsa000712.64835793
11Oxidative phosphorylation_Homo sapiens_hsa001902.56096698
12Carbon metabolism_Homo sapiens_hsa012002.46262093
13Alzheimers disease_Homo sapiens_hsa050102.09920861
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.04556524
15Fatty acid metabolism_Homo sapiens_hsa012121.97149769
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.94285543
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.92098288
18Viral myocarditis_Homo sapiens_hsa054161.85160886
19Pyruvate metabolism_Homo sapiens_hsa006201.70288875
20Huntingtons disease_Homo sapiens_hsa050161.67324600
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.43764308
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38568955
23Glucagon signaling pathway_Homo sapiens_hsa049221.36248384
24Starch and sucrose metabolism_Homo sapiens_hsa005001.36037564
25Insulin resistance_Homo sapiens_hsa049311.34190600
26Biosynthesis of amino acids_Homo sapiens_hsa012301.23148429
27Insulin signaling pathway_Homo sapiens_hsa049101.23021240
28cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16187827
29Adipocytokine signaling pathway_Homo sapiens_hsa049201.13348955
30Butanoate metabolism_Homo sapiens_hsa006501.08362392
31Fatty acid elongation_Homo sapiens_hsa000621.01490416
32Oxytocin signaling pathway_Homo sapiens_hsa049211.00931644
33Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96031130
34AMPK signaling pathway_Homo sapiens_hsa041520.96001960
35Calcium signaling pathway_Homo sapiens_hsa040200.95006141
36Focal adhesion_Homo sapiens_hsa045100.93354014
37Tight junction_Homo sapiens_hsa045300.87911961
38PPAR signaling pathway_Homo sapiens_hsa033200.86766676
39HIF-1 signaling pathway_Homo sapiens_hsa040660.79567894
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.77961711
41Galactose metabolism_Homo sapiens_hsa000520.72376948
42Nitrogen metabolism_Homo sapiens_hsa009100.72364587
43Vascular smooth muscle contraction_Homo sapiens_hsa042700.71521032
44Circadian rhythm_Homo sapiens_hsa047100.69225418
45Lysine degradation_Homo sapiens_hsa003100.68172802
46Arginine and proline metabolism_Homo sapiens_hsa003300.66752948
47Central carbon metabolism in cancer_Homo sapiens_hsa052300.66280064
48beta-Alanine metabolism_Homo sapiens_hsa004100.60674065
49Salivary secretion_Homo sapiens_hsa049700.59686515
50Arginine biosynthesis_Homo sapiens_hsa002200.59484131
51Type II diabetes mellitus_Homo sapiens_hsa049300.57095891
52Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57079027
53Fructose and mannose metabolism_Homo sapiens_hsa000510.56211598
54Long-term potentiation_Homo sapiens_hsa047200.55968410
55Tryptophan metabolism_Homo sapiens_hsa003800.55752857
56Adherens junction_Homo sapiens_hsa045200.53546668
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52423298
58ECM-receptor interaction_Homo sapiens_hsa045120.52368151
59Gastric acid secretion_Homo sapiens_hsa049710.52014121
60Renin secretion_Homo sapiens_hsa049240.50227141
61Fatty acid biosynthesis_Homo sapiens_hsa000610.49746832
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49534150
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47607587
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46252837
65Amphetamine addiction_Homo sapiens_hsa050310.40364182
66Amoebiasis_Homo sapiens_hsa051460.40147574
67Insulin secretion_Homo sapiens_hsa049110.38392487
68mTOR signaling pathway_Homo sapiens_hsa041500.37770365
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37454442
70cAMP signaling pathway_Homo sapiens_hsa040240.35785187
71Phenylalanine metabolism_Homo sapiens_hsa003600.35513214
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35209851
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34294186
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32047889
75Proteoglycans in cancer_Homo sapiens_hsa052050.31814001
76Regulation of autophagy_Homo sapiens_hsa041400.30653515
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.30514898
78GnRH signaling pathway_Homo sapiens_hsa049120.29795774
79Melanogenesis_Homo sapiens_hsa049160.28558208
80FoxO signaling pathway_Homo sapiens_hsa040680.26788657
81Peroxisome_Homo sapiens_hsa041460.26139870
82Platelet activation_Homo sapiens_hsa046110.25864387
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25684672
84Phototransduction_Homo sapiens_hsa047440.24971839
85Olfactory transduction_Homo sapiens_hsa047400.24900810
86VEGF signaling pathway_Homo sapiens_hsa043700.24663907
87Renal cell carcinoma_Homo sapiens_hsa052110.22849050
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.22788124
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.21737822
90Circadian entrainment_Homo sapiens_hsa047130.21368249
91Linoleic acid metabolism_Homo sapiens_hsa005910.18732281
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.16364696
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15398628
94MAPK signaling pathway_Homo sapiens_hsa040100.15032204
95Long-term depression_Homo sapiens_hsa047300.14694076
96Protein digestion and absorption_Homo sapiens_hsa049740.13991623
97Metabolic pathways_Homo sapiens_hsa011000.13734850
98GABAergic synapse_Homo sapiens_hsa047270.13476543
99Pentose phosphate pathway_Homo sapiens_hsa000300.13302344
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.13266054
101Dorso-ventral axis formation_Homo sapiens_hsa043200.12536952
102Sulfur relay system_Homo sapiens_hsa041220.11201932
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.09934523
104Cholinergic synapse_Homo sapiens_hsa047250.09406159
105Ovarian steroidogenesis_Homo sapiens_hsa049130.09290147
106Cysteine and methionine metabolism_Homo sapiens_hsa002700.09139054
107Gap junction_Homo sapiens_hsa045400.09041210
108Pancreatic secretion_Homo sapiens_hsa049720.08362405
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.08136373
110Small cell lung cancer_Homo sapiens_hsa052220.07412044
111Toxoplasmosis_Homo sapiens_hsa051450.06378653
112Fat digestion and absorption_Homo sapiens_hsa049750.05891204
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.05140866
114Tyrosine metabolism_Homo sapiens_hsa003500.03240931
115Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.02288308
116Notch signaling pathway_Homo sapiens_hsa043300.01972070
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.00696586
118Bile secretion_Homo sapiens_hsa049760.00519327

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