ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	limb bud formation (GO:0060174)	7.50705351
2	somite development (GO:0061053)	4.70467718
3	negative regulation of axon guidance (GO:1902668)	4.53484047
4	negative regulation of translation, ncRNA-mediated (GO:0040033)	4.25174160
5	regulation of translation, ncRNA-mediated (GO:0045974)	4.25174160
6	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	4.25174160
7	response to pheromone (GO:0019236)	4.21786760
8	neural tube formation (GO:0001841)	3.95830349
9	lactate metabolic process (GO:0006089)	3.93371153
10	replication fork processing (GO:0031297)	3.76886887
11	genitalia morphogenesis (GO:0035112)	3.64088508
12	cornea development in camera-type eye (GO:0061303)	3.59741597
13	mitotic sister chromatid cohesion (GO:0007064)	3.52335275
14	nonmotile primary cilium assembly (GO:0035058)	3.43564270
15	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.41473647
16	glial cell proliferation (GO:0014009)	3.41293010
17	regulation of axon guidance (GO:1902667)	3.40972616
18	pharyngeal system development (GO:0060037)	3.39104609
19	embryonic retina morphogenesis in camera-type eye (GO:0060059)	3.30754999
20	protein K11-linked deubiquitination (GO:0035871)	3.23891810
21	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	3.21787706
22	sialylation (GO:0097503)	3.16190540
23	centrosome localization (GO:0051642)	3.15763577
24	negative regulation of axon extension involved in axon guidance (GO:0048843)	3.14948053
25	otic vesicle formation (GO:0030916)	3.14878381
26	sympathetic nervous system development (GO:0048485)	3.14419685
27	fatty acid transmembrane transport (GO:1902001)	3.10727504
28	histone H2A acetylation (GO:0043968)	3.08783439
29	ketone body metabolic process (GO:1902224)	3.03937973
30	regulation of hexokinase activity (GO:1903299)	3.03232580
31	regulation of glucokinase activity (GO:0033131)	3.03232580
32	retinal ganglion cell axon guidance (GO:0031290)	3.02458124
33	branched-chain amino acid catabolic process (GO:0009083)	2.99629710
34	regulation of DNA endoreduplication (GO:0032875)	2.99420139
35	photoreceptor cell maintenance (GO:0045494)	2.97978313
36	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.97972710
37	regulation of hippo signaling (GO:0035330)	2.93944681
38	olfactory bulb development (GO:0021772)	2.91193694
39	peptidyl-histidine modification (GO:0018202)	2.89964962
40	cellular ketone body metabolic process (GO:0046950)	2.89439814
41	negative regulation of mast cell activation (GO:0033004)	2.89053430
42	detection of light stimulus involved in sensory perception (GO:0050962)	2.85215233
43	detection of light stimulus involved in visual perception (GO:0050908)	2.85215233
44	regulation of memory T cell differentiation (GO:0043380)	2.81271419
45	regulation of heat generation (GO:0031650)	2.77361690
46	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	2.75876448
47	intraciliary transport (GO:0042073)	2.75862654
48	pyrimidine nucleobase catabolic process (GO:0006208)	2.72283192
49	fucose catabolic process (GO:0019317)	2.69521399
50	L-fucose metabolic process (GO:0042354)	2.69521399
51	L-fucose catabolic process (GO:0042355)	2.69521399
52	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.66930644
53	regulation of neurotransmitter uptake (GO:0051580)	2.62729783
54	regulation of telomere maintenance (GO:0032204)	2.62113655
55	serotonin metabolic process (GO:0042428)	2.60380779
56	behavioral response to ethanol (GO:0048149)	2.59929824
57	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.57449153
58	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.57449153
59	NLS-bearing protein import into nucleus (GO:0006607)	2.57362461
60	regulation of cilium movement (GO:0003352)	2.56459986
61	sister chromatid cohesion (GO:0007062)	2.56395802
62	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.54907359
63	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.52941479
64	ADP metabolic process (GO:0046031)	2.52757759
65	phagocytosis, recognition (GO:0006910)	2.52081559
66	primary amino compound metabolic process (GO:1901160)	2.51039371
67	positive regulation of amino acid transport (GO:0051957)	2.50339865
68	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.48810728
69	positive regulation of glycoprotein biosynthetic process (GO:0010560)	2.48695192
70	cilium assembly (GO:0042384)	2.47093461
71	myelin assembly (GO:0032288)	2.46826309
72	cilium organization (GO:0044782)	2.46114059
73	spinal cord development (GO:0021510)	2.46084875
74	neuronal action potential propagation (GO:0019227)	2.45686136
75	regulation of meiosis I (GO:0060631)	2.43962561
76	kynurenine metabolic process (GO:0070189)	2.43826614
77	valine metabolic process (GO:0006573)	2.42948162
78	regulation of axon extension involved in axon guidance (GO:0048841)	2.42849495
79	gamma-aminobutyric acid transport (GO:0015812)	2.41365203
80	reciprocal meiotic recombination (GO:0007131)	2.38780771
81	reciprocal DNA recombination (GO:0035825)	2.38780771
82	regulation of penile erection (GO:0060405)	2.37241795
83	neuroepithelial cell differentiation (GO:0060563)	2.37010499
84	platelet dense granule organization (GO:0060155)	2.36517562
85	epithelial cilium movement (GO:0003351)	2.36206612
86	centriole replication (GO:0007099)	2.35281645
87	embryonic digestive tract morphogenesis (GO:0048557)	2.34723371
88	microtubule anchoring (GO:0034453)	2.34050080
89	cell migration in hindbrain (GO:0021535)	2.33508690
90	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.32997343
91	regulation of centriole replication (GO:0046599)	2.32628357
92	regulation of feeding behavior (GO:0060259)	2.31900688
93	inositol phosphate catabolic process (GO:0071545)	2.31231457
94	double-strand break repair via homologous recombination (GO:0000724)	2.31055086
95	indolalkylamine metabolic process (GO:0006586)	2.29693426
96	recombinational repair (GO:0000725)	2.27892944
97	DNA double-strand break processing (GO:0000729)	2.27783936
98	auditory receptor cell differentiation (GO:0042491)	2.27773438
99	dorsal/ventral axis specification (GO:0009950)	2.26892182
100	negative regulation of dendrite development (GO:2000171)	2.26881118

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SALL1_21062744_ChIP-ChIP_HESCs_Human	4.16639930
2	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.32873945
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.03430291
4	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.94238669
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.93129558
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.89973636
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.79732340
8	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.72112393
9	FUS_26573619_Chip-Seq_HEK293_Human	2.59768453
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.48321148
11	EWS_26573619_Chip-Seq_HEK293_Human	2.34278488
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.31690016
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.22269315
14	P300_19829295_ChIP-Seq_ESCs_Human	2.15192162
15	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.08141394
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.01723989
17	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.00134320
18	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.98564022
19	VDR_22108803_ChIP-Seq_LS180_Human	1.92161792
20	BCAT_22108803_ChIP-Seq_LS180_Human	1.76750933
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.75122845
22	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.73435130
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.72467375
24	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.70528656
25	STAT3_23295773_ChIP-Seq_U87_Human	1.70002873
26	SMAD4_21799915_ChIP-Seq_A2780_Human	1.68418355
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.65505001
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.62596050
29	GATA1_22025678_ChIP-Seq_K562_Human	1.61884551
30	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.61530349
31	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.61338275
32	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.57087241
33	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.55922807
34	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.55922807
35	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.55784018
36	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.53476798
37	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.53256978
38	TCF4_23295773_ChIP-Seq_U87_Human	1.49713472
39	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.49637720
40	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.47825521
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.46364248
42	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.46364248
43	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.46200509
44	TCF4_22108803_ChIP-Seq_LS180_Human	1.45916998
45	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.45195083
46	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.42093288
47	AR_25329375_ChIP-Seq_VCAP_Human	1.41954000
48	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.40085456
49	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.35036738
50	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.34356250
51	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.33943949
52	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.32796407
53	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.32708588
54	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.32524335
55	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.32320242
56	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.32135309
57	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.32036158
58	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.30966922
59	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30000605
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30000605
61	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.28329380
62	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.27455959
63	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.26908318
64	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.26342859
65	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.23222605
66	RUNX2_22187159_ChIP-Seq_PCA_Human	1.22479652
67	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.22226343
68	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.21881623
69	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.19729482
70	ELK1_19687146_ChIP-ChIP_HELA_Human	1.17548728
71	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.16704629
72	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.15758290
73	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.15464376
74	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.14531884
75	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.13553742
76	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.12561055
77	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.11311561
78	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.10935999
79	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.09126709
80	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.08713321
81	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.07961124
82	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.07416682
83	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.07369124
84	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.07122189
85	AR_21572438_ChIP-Seq_LNCaP_Human	1.06975138
86	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.06844386
87	CDX2_22108803_ChIP-Seq_LS180_Human	1.06356132
88	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.06169666
89	RNF2_27304074_Chip-Seq_NSC_Mouse	1.04976980
90	P53_22387025_ChIP-Seq_ESCs_Mouse	1.04966563
91	HOXB7_26014856_ChIP-Seq_BT474_Human	1.03738658
92	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.03661198
93	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.03661198
94	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.03124822
95	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.02593659
96	MYC_18940864_ChIP-ChIP_HL60_Human	1.01581460
97	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.00383995
98	RXR_22108803_ChIP-Seq_LS180_Human	1.00025331
99	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.99587151
100	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.98903438

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	5.04104998
2	MP0000372_irregular_coat_pigmentation	4.95042229
3	MP0002938_white_spotting	3.38920273
4	MP0005174_abnormal_tail_pigmentation	3.37851890
5	MP0005075_abnormal_melanosome_morpholog	3.36530543
6	MP0003136_yellow_coat_color	2.88002735
7	MP0002822_catalepsy	2.84681883
8	MP0001986_abnormal_taste_sensitivity	2.57391615
9	MP0000015_abnormal_ear_pigmentation	2.47829192
10	MP0005408_hypopigmentation	2.29576370
11	MP0002102_abnormal_ear_morphology	2.25089021
12	MP0003195_calcinosis	2.20953880
13	MP0005551_abnormal_eye_electrophysiolog	2.14900101
14	MP0000371_diluted_coat_color	2.03910729
15	MP0005367_renal/urinary_system_phenotyp	1.90062588
16	MP0000516_abnormal_urinary_system	1.90062588
17	MP0006072_abnormal_retinal_apoptosis	1.89726897
18	MP0005171_absent_coat_pigmentation	1.86338836
19	MP0005253_abnormal_eye_physiology	1.83915464
20	MP0002095_abnormal_skin_pigmentation	1.77354602
21	MP0008057_abnormal_DNA_replication	1.76672947
22	MP0000647_abnormal_sebaceous_gland	1.70921066
23	MP0004381_abnormal_hair_follicle	1.68873573
24	MP0002736_abnormal_nociception_after	1.65225766
25	MP0002751_abnormal_autonomic_nervous	1.62024842
26	MP0008877_abnormal_DNA_methylation	1.61177219
27	MP0001324_abnormal_eye_pigmentation	1.58837515
28	MP0003718_maternal_effect	1.57972712
29	MP0003567_abnormal_fetal_cardiomyocyte	1.57891134
30	MP0005670_abnormal_white_adipose	1.53337928
31	MP0002638_abnormal_pupillary_reflex	1.51018124
32	MP0003937_abnormal_limbs/digits/tail_de	1.47045935
33	MP0005248_abnormal_Harderian_gland	1.46410207
34	MP0003890_abnormal_embryonic-extraembry	1.38870029
35	MP0010094_abnormal_chromosome_stability	1.37012283
36	MP0005187_abnormal_penis_morphology	1.36798411
37	MP0000383_abnormal_hair_follicle	1.36007342
38	MP0001764_abnormal_homeostasis	1.35773636
39	MP0008058_abnormal_DNA_repair	1.34551277
40	MP0003950_abnormal_plasma_membrane	1.32647542
41	MP0001984_abnormal_olfaction	1.32053569
42	MP0002254_reproductive_system_inflammat	1.31508936
43	MP0000427_abnormal_hair_cycle	1.30857467
44	MP0005423_abnormal_somatic_nervous	1.28169325
45	MP0001485_abnormal_pinna_reflex	1.26481470
46	MP0002837_dystrophic_cardiac_calcinosis	1.26220584
47	MP0005645_abnormal_hypothalamus_physiol	1.22237871
48	MP0000778_abnormal_nervous_system	1.17392204
49	MP0001486_abnormal_startle_reflex	1.15687004
50	MP0004147_increased_porphyrin_level	1.14756249
51	MP0001968_abnormal_touch/_nociception	1.13321397
52	MP0002090_abnormal_vision	1.12069387
53	MP0002127_abnormal_cardiovascular_syste	1.11304177
54	MP0004133_heterotaxia	1.10420311
55	MP0002233_abnormal_nose_morphology	1.10332019
56	MP0001293_anophthalmia	1.07492337
57	MP0010678_abnormal_skin_adnexa	1.07377074
58	MP0009745_abnormal_behavioral_response	1.03595896
59	MP0003693_abnormal_embryo_hatching	0.97661011
60	MP0009046_muscle_twitch	0.97179278
61	MP0004142_abnormal_muscle_tone	0.97151805
62	MP0005395_other_phenotype	0.95519013
63	MP0003755_abnormal_palate_morphology	0.94709186
64	MP0005391_vision/eye_phenotype	0.92875033
65	MP0004215_abnormal_myocardial_fiber	0.91811457
66	MP0001286_abnormal_eye_development	0.88302173
67	MP0002075_abnormal_coat/hair_pigmentati	0.87931199
68	MP0003943_abnormal_hepatobiliary_system	0.84554037
69	MP0006276_abnormal_autonomic_nervous	0.84296259
70	MP0001299_abnormal_eye_distance/	0.83834649
71	MP0003880_abnormal_central_pattern	0.82182781
72	MP0004145_abnormal_muscle_electrophysio	0.80973430
73	MP0005195_abnormal_posterior_eye	0.80633965
74	MP0005386_behavior/neurological_phenoty	0.79612240
75	MP0004924_abnormal_behavior	0.79612240
76	MP0009697_abnormal_copulation	0.76906857
77	MP0003137_abnormal_impulse_conducting	0.76888691
78	MP0002234_abnormal_pharynx_morphology	0.74874488
79	MP0003935_abnormal_craniofacial_develop	0.74655648
80	MP0002752_abnormal_somatic_nervous	0.74362794
81	MP0001188_hyperpigmentation	0.73374062
82	MP0000631_abnormal_neuroendocrine_gland	0.73300830
83	MP0008775_abnormal_heart_ventricle	0.72108698
84	MP0003868_abnormal_feces_composition	0.69456692
85	MP0002272_abnormal_nervous_system	0.68260148
86	MP0001661_extended_life_span	0.67993506
87	MP0003646_muscle_fatigue	0.67977411
88	MP0003698_abnormal_male_reproductive	0.65194907
89	MP0002168_other_aberrant_phenotype	0.64818111
90	MP0002177_abnormal_outer_ear	0.63736283
91	MP0002735_abnormal_chemical_nociception	0.62347838
92	MP0001929_abnormal_gametogenesis	0.61917317
93	MP0006054_spinal_hemorrhage	0.61775927
94	MP0001697_abnormal_embryo_size	0.61512397
95	MP0009780_abnormal_chondrocyte_physiolo	0.61405453
96	MP0003283_abnormal_digestive_organ	0.61190231
97	MP0002557_abnormal_social/conspecific_i	0.61096626
98	MP0003119_abnormal_digestive_system	0.59697854
99	MP0005646_abnormal_pituitary_gland	0.59472502
100	MP0008932_abnormal_embryonic_tissue	0.59270716

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the labia minora (HP:0012880)	4.61156458
2	Oligodactyly (hands) (HP:0001180)	4.17367111
3	Intestinal atresia (HP:0011100)	4.08400447
4	Aplasia/Hypoplasia of the sternum (HP:0006714)	4.07250259
5	Long clavicles (HP:0000890)	3.89178625
6	Volvulus (HP:0002580)	3.48858300
7	Hypoplastic labia majora (HP:0000059)	3.47241279
8	Hepatoblastoma (HP:0002884)	3.33620861
9	Abnormality of the labia majora (HP:0012881)	3.23428921
10	Aqueductal stenosis (HP:0002410)	3.21896062
11	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	3.18502769
12	Short 1st metacarpal (HP:0010034)	3.18502769
13	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.12731205
14	Hypoplastic female external genitalia (HP:0012815)	3.11971033
15	Labial hypoplasia (HP:0000066)	3.07358654
16	True hermaphroditism (HP:0010459)	2.97592666
17	Hypoplastic pelvis (HP:0008839)	2.95409431
18	Pancreatic cysts (HP:0001737)	2.95039572
19	Pancreatic fibrosis (HP:0100732)	2.90867516
20	Abnormality of the 1st metacarpal (HP:0010009)	2.74846981
21	Short phalanx of the thumb (HP:0009660)	2.64459850
22	Decreased lacrimation (HP:0000633)	2.63541514
23	Oligodactyly (HP:0012165)	2.62463551
24	Abnormality of midbrain morphology (HP:0002418)	2.58544107
25	Molar tooth sign on MRI (HP:0002419)	2.58544107
26	Hyperventilation (HP:0002883)	2.56083414
27	Medial flaring of the eyebrow (HP:0010747)	2.53198680
28	Gaze-evoked nystagmus (HP:0000640)	2.48187550
29	Albinism (HP:0001022)	2.40226181
30	Anencephaly (HP:0002323)	2.37786038
31	Gait imbalance (HP:0002141)	2.35534754
32	Congenital primary aphakia (HP:0007707)	2.34097462
33	Genital tract atresia (HP:0001827)	2.31983692
34	Gastrointestinal atresia (HP:0002589)	2.31821371
35	Abnormality of the labia (HP:0000058)	2.30594332
36	Megalencephaly (HP:0001355)	2.29721687
37	Alacrima (HP:0000522)	2.29504829
38	Abnormality of the pubic bones (HP:0003172)	2.28499170
39	Vaginal atresia (HP:0000148)	2.21806880
40	Chin dimple (HP:0010751)	2.21533183
41	Abnormal hair whorl (HP:0010721)	2.20606309
42	Pancreatic islet-cell hyperplasia (HP:0004510)	2.19263414
43	Type II lissencephaly (HP:0007260)	2.17294410
44	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	2.16747201
45	Adactyly (HP:0009776)	2.16673857
46	Chromsome breakage (HP:0040012)	2.16016745
47	Facial hemangioma (HP:0000329)	2.14248845
48	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.12545189
49	Renal hypoplasia (HP:0000089)	2.09890789
50	Abnormality of the renal medulla (HP:0100957)	2.08639844
51	Cupped ear (HP:0000378)	2.08155141
52	Nephronophthisis (HP:0000090)	2.04790235
53	Increased density of long bones (HP:0006392)	2.03897458
54	White forelock (HP:0002211)	2.02457792
55	Sloping forehead (HP:0000340)	2.00851722
56	Nephrogenic diabetes insipidus (HP:0009806)	1.99656847
57	Abnormality of the renal cortex (HP:0011035)	1.99361010
58	Dandy-Walker malformation (HP:0001305)	1.96674519
59	Hypoplasia of the fovea (HP:0007750)	1.96258503
60	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.96258503
61	Abnormality of the pons (HP:0007361)	1.95384079
62	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.95302365
63	Aplasia/Hypoplasia of the macula (HP:0008059)	1.94695683
64	Chronic hepatic failure (HP:0100626)	1.94549684
65	Esophageal atresia (HP:0002032)	1.92674411
66	Patchy hypopigmentation of hair (HP:0011365)	1.92338324
67	Astigmatism (HP:0000483)	1.91756261
68	Pheochromocytoma (HP:0002666)	1.91375126
69	Hypoplastic nipples (HP:0002557)	1.90999760
70	Absent eyebrow (HP:0002223)	1.89279689
71	Abnormality of methionine metabolism (HP:0010901)	1.88772336
72	Anophthalmia (HP:0000528)	1.88722709
73	Bifid tongue (HP:0010297)	1.86093621
74	Hypoplasia of the pons (HP:0012110)	1.86007087
75	Blue irides (HP:0000635)	1.84614460
76	Hypoplastic ischia (HP:0003175)	1.82810055
77	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.82661216
78	Narrow forehead (HP:0000341)	1.81136853
79	Aplasia/Hypoplasia affecting the retina (HP:0008061)	1.80124134
80	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.78478323
81	Short thumb (HP:0009778)	1.77806287
82	Optic nerve hypoplasia (HP:0000609)	1.77768960
83	Ectopic kidney (HP:0000086)	1.77739777
84	Postaxial hand polydactyly (HP:0001162)	1.77212224
85	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.75303115
86	Abnormal lung lobation (HP:0002101)	1.73158440
87	Sclerocornea (HP:0000647)	1.71794217
88	Thyroiditis (HP:0100646)	1.70956431
89	Abnormality of the metopic suture (HP:0005556)	1.70843450
90	Neuroendocrine neoplasm (HP:0100634)	1.70162800
91	Abnormality of chromosome stability (HP:0003220)	1.69276236
92	Preaxial hand polydactyly (HP:0001177)	1.68321788
93	Generalized hypopigmentation (HP:0007513)	1.67245390
94	Poor coordination (HP:0002370)	1.65988126
95	Hypophosphatemic rickets (HP:0004912)	1.65804795
96	Aplasia/Hypoplasia of the nipples (HP:0006709)	1.64943466
97	Fair hair (HP:0002286)	1.63836377
98	Abnormality of the duodenum (HP:0002246)	1.62809693
99	Furrowed tongue (HP:0000221)	1.61149360
100	Patellar aplasia (HP:0006443)	1.60380688

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.21265358
2	MAP4K2	3.76022765
3	PINK1	3.46520286
4	ACVR1B	3.10635803
5	BRSK2	3.06925832
6	BMPR1B	2.75045034
7	MARK3	2.67110939
8	TRIM28	2.40564777
9	WNK3	2.35541183
10	MAPK13	2.31223783
11	PNCK	2.27700144
12	TNIK	2.23873924
13	FGFR2	2.00250162
14	STK39	1.99560024
15	ERBB3	1.96964673
16	TIE1	1.96628321
17	WEE1	1.86462394
18	MKNK1	1.74355528
19	BUB1	1.68869679
20	PAK3	1.58380988
21	AKT3	1.55545772
22	PLK3	1.54713207
23	TTK	1.51751151
24	GRK1	1.49763080
25	MKNK2	1.49519302
26	PDK2	1.48397116
27	MARK1	1.47797002
28	CCNB1	1.46448214
29	NUAK1	1.45161757
30	OXSR1	1.40922657
31	CASK	1.34461609
32	CAMK1G	1.29431101
33	KSR1	1.26425756
34	ZAK	1.25318796
35	BRSK1	1.18567517
36	PLK4	1.15174171
37	FER	1.13792865
38	PKN1	1.12847890
39	BRD4	1.07775828
40	OBSCN	1.03476355
41	BRAF	1.03115916
42	PLK2	0.97946683
43	PRKCI	0.96883144
44	SIK3	0.95125734
45	NEK6	0.91213004
46	MST4	0.89192885
47	NLK	0.86667963
48	EIF2AK3	0.85866450
49	BCR	0.78390307
50	CAMK1D	0.78275833
51	MAP3K4	0.77654996
52	FGFR1	0.75762499
53	PLK1	0.75672155
54	TGFBR1	0.74732977
55	STK3	0.73829444
56	EPHA4	0.73678559
57	PRKCE	0.72465840
58	INSRR	0.68997063
59	MAPKAPK5	0.66891556
60	NEK1	0.65354938
61	CSNK1G1	0.63958044
62	TEC	0.62807211
63	STK38L	0.62280405
64	PHKG2	0.62040519
65	PHKG1	0.62040519
66	CHEK2	0.55119985
67	PRKCG	0.54449286
68	ATM	0.53804462
69	WNK4	0.53430385
70	MINK1	0.53318569
71	STK11	0.52651244
72	DAPK2	0.49710110
73	SRPK1	0.49513778
74	ADRBK2	0.48845599
75	MUSK	0.48247940
76	PRKCZ	0.48201641
77	VRK1	0.47737481
78	DYRK2	0.47426607
79	ROCK1	0.46118679
80	ATR	0.44525251
81	CSNK1A1L	0.43845500
82	PTK2B	0.42499505
83	GRK7	0.41864584
84	PRKAA2	0.40170905
85	NTRK2	0.40162360
86	CSNK1G2	0.39085761
87	RAF1	0.38921467
88	DYRK3	0.37313862
89	PIK3CG	0.34297839
90	PRKACB	0.34040039
91	SGK2	0.33225968
92	CSNK1G3	0.31881341
93	PRKAA1	0.31566922
94	CSNK1D	0.30840366
95	CHEK1	0.30757045
96	RPS6KA5	0.29968966
97	CSNK1A1	0.29258514
98	EPHB2	0.29182416
99	PRKDC	0.28955455
100	PRKCH	0.27728599

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.38389704
2	Non-homologous end-joining_Homo sapiens_hsa03450	3.76455020
3	Propanoate metabolism_Homo sapiens_hsa00640	3.36808157
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.46566213
5	Homologous recombination_Homo sapiens_hsa03440	2.35417124
6	Protein export_Homo sapiens_hsa03060	2.35356964
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.34415790
8	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.23176675
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.19665103
10	Phototransduction_Homo sapiens_hsa04744	1.93274544
11	Butanoate metabolism_Homo sapiens_hsa00650	1.87819224
12	Basal transcription factors_Homo sapiens_hsa03022	1.83584360
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.81400038
14	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.78044508
15	Nucleotide excision repair_Homo sapiens_hsa03420	1.57645991
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.54886882
17	Fatty acid elongation_Homo sapiens_hsa00062	1.51993867
18	Fat digestion and absorption_Homo sapiens_hsa04975	1.44129295
19	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.43941046
20	Proteasome_Homo sapiens_hsa03050	1.43351495
21	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.39212098
22	Circadian rhythm_Homo sapiens_hsa04710	1.38115787
23	Steroid biosynthesis_Homo sapiens_hsa00100	1.35661344
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.34687839
25	Caffeine metabolism_Homo sapiens_hsa00232	1.32116882
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.31706028
27	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.30453205
28	Mismatch repair_Homo sapiens_hsa03430	1.29694855
29	RNA degradation_Homo sapiens_hsa03018	1.28758599
30	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.28326916
31	ABC transporters_Homo sapiens_hsa02010	1.28164760
32	Tryptophan metabolism_Homo sapiens_hsa00380	1.28110741
33	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.20804590
34	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.19881330
35	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.18998929
36	Ether lipid metabolism_Homo sapiens_hsa00565	1.16297947
37	Lysine degradation_Homo sapiens_hsa00310	1.15181475
38	Peroxisome_Homo sapiens_hsa04146	1.11139837
39	Nicotine addiction_Homo sapiens_hsa05033	1.03181664
40	Fatty acid metabolism_Homo sapiens_hsa01212	0.99999414
41	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.99307340
42	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.98325190
43	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.96970428
44	Regulation of autophagy_Homo sapiens_hsa04140	0.93652889
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.90762777
46	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.88375384
47	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.88092916
48	Pyruvate metabolism_Homo sapiens_hsa00620	0.86164683
49	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.85274554
50	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.84881058
51	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.84166621
52	Selenocompound metabolism_Homo sapiens_hsa00450	0.82740934
53	RNA polymerase_Homo sapiens_hsa03020	0.79807785
54	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.76368557
55	Cell cycle_Homo sapiens_hsa04110	0.75009314
56	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.74947071
57	Purine metabolism_Homo sapiens_hsa00230	0.72983034
58	Cocaine addiction_Homo sapiens_hsa05030	0.69225991
59	Sphingolipid metabolism_Homo sapiens_hsa00600	0.68316850
60	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.68101853
61	Insulin secretion_Homo sapiens_hsa04911	0.67871343
62	Collecting duct acid secretion_Homo sapiens_hsa04966	0.67800787
63	Oocyte meiosis_Homo sapiens_hsa04114	0.66719574
64	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.66324464
65	Glucagon signaling pathway_Homo sapiens_hsa04922	0.65719754
66	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.65287109
67	Tight junction_Homo sapiens_hsa04530	0.64674594
68	Chemical carcinogenesis_Homo sapiens_hsa05204	0.63796647
69	Axon guidance_Homo sapiens_hsa04360	0.60939261
70	Taste transduction_Homo sapiens_hsa04742	0.59897704
71	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.58633836
72	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.56759460
73	Serotonergic synapse_Homo sapiens_hsa04726	0.55514703
74	Prostate cancer_Homo sapiens_hsa05215	0.54623129
75	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.53256049
76	Olfactory transduction_Homo sapiens_hsa04740	0.53241334
77	Arginine and proline metabolism_Homo sapiens_hsa00330	0.51740050
78	Glutathione metabolism_Homo sapiens_hsa00480	0.49910997
79	Metabolic pathways_Homo sapiens_hsa01100	0.49562861
80	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.48632673
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48382452
82	Oxidative phosphorylation_Homo sapiens_hsa00190	0.47823015
83	Dopaminergic synapse_Homo sapiens_hsa04728	0.47448073
84	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.47372388
85	p53 signaling pathway_Homo sapiens_hsa04115	0.45287407
86	DNA replication_Homo sapiens_hsa03030	0.44198894
87	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.44191916
88	Glycerolipid metabolism_Homo sapiens_hsa00561	0.42309618
89	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.41032847
90	RNA transport_Homo sapiens_hsa03013	0.40189144
91	Basal cell carcinoma_Homo sapiens_hsa05217	0.37229977
92	Hippo signaling pathway_Homo sapiens_hsa04390	0.36284935
93	Fatty acid degradation_Homo sapiens_hsa00071	0.36070295
94	Calcium signaling pathway_Homo sapiens_hsa04020	0.34285552
95	Morphine addiction_Homo sapiens_hsa05032	0.31825218
96	Tyrosine metabolism_Homo sapiens_hsa00350	0.31802238
97	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.31145310
98	Huntingtons disease_Homo sapiens_hsa05016	0.30547560
99	Melanoma_Homo sapiens_hsa05218	0.30386326
100	Pyrimidine metabolism_Homo sapiens_hsa00240	0.29716684

SRMP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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