

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 7.18695376 |
| 2 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 6.90243070 |
| 3 | ATP synthesis coupled proton transport (GO:0015986) | 6.90243070 |
| 4 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 6.63265850 |
| 5 | axon ensheathment in central nervous system (GO:0032291) | 6.57117407 |
| 6 | central nervous system myelination (GO:0022010) | 6.57117407 |
| 7 | protein neddylation (GO:0045116) | 5.86767744 |
| 8 | respiratory electron transport chain (GO:0022904) | 5.66389877 |
| 9 | electron transport chain (GO:0022900) | 5.55043672 |
| 10 | chaperone-mediated protein transport (GO:0072321) | 5.41232215 |
| 11 | sequestering of actin monomers (GO:0042989) | 4.74304955 |
| 12 | fatty acid elongation (GO:0030497) | 4.68231904 |
| 13 | long-chain fatty acid biosynthetic process (GO:0042759) | 4.61007832 |
| 14 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.40957028 |
| 15 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.08200021 |
| 16 | NADH dehydrogenase complex assembly (GO:0010257) | 4.08200021 |
| 17 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.08200021 |
| 18 | protein complex biogenesis (GO:0070271) | 4.07491962 |
| 19 | ribosomal small subunit biogenesis (GO:0042274) | 3.88905742 |
| 20 | substantia nigra development (GO:0021762) | 3.83278337 |
| 21 | hydrogen ion transmembrane transport (GO:1902600) | 3.82253656 |
| 22 | GTP biosynthetic process (GO:0006183) | 3.82026791 |
| 23 | platelet dense granule organization (GO:0060155) | 3.76515552 |
| 24 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.58889979 |
| 25 | myelination (GO:0042552) | 3.53888265 |
| 26 | epithelial cilium movement (GO:0003351) | 3.51344866 |
| 27 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.50141776 |
| 28 | cytochrome complex assembly (GO:0017004) | 3.50107475 |
| 29 | ensheathment of neurons (GO:0007272) | 3.50101785 |
| 30 | axon ensheathment (GO:0008366) | 3.50101785 |
| 31 | proton transport (GO:0015992) | 3.48824808 |
| 32 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.47636247 |
| 33 | behavioral response to nicotine (GO:0035095) | 3.46682072 |
| 34 | dopamine biosynthetic process (GO:0042416) | 3.41908339 |
| 35 | hydrogen transport (GO:0006818) | 3.40068462 |
| 36 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.38684513 |
| 37 | ATP biosynthetic process (GO:0006754) | 3.37810377 |
| 38 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.36051695 |
| 39 | response to redox state (GO:0051775) | 3.33896004 |
| 40 | ribosomal small subunit assembly (GO:0000028) | 3.31315180 |
| 41 | neuron cell-cell adhesion (GO:0007158) | 3.28888105 |
| 42 | proteasome assembly (GO:0043248) | 3.28757431 |
| 43 | DNA damage response, detection of DNA damage (GO:0042769) | 3.26010002 |
| 44 | negative regulation of neurotransmitter transport (GO:0051589) | 3.25283604 |
| 45 | intraciliary transport (GO:0042073) | 3.25002880 |
| 46 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.22694217 |
| 47 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.22694217 |
| 48 | GPI anchor biosynthetic process (GO:0006506) | 3.22147277 |
| 49 | * cotranslational protein targeting to membrane (GO:0006613) | 3.21876588 |
| 50 | viral transcription (GO:0019083) | 3.20465212 |
| 51 | cholesterol biosynthetic process (GO:0006695) | 3.19790776 |
| 52 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.18681247 |
| 53 | presynaptic membrane organization (GO:0097090) | 3.13726415 |
| 54 | ATP hydrolysis coupled proton transport (GO:0015991) | 3.13230041 |
| 55 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 3.13230041 |
| 56 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.11156998 |
| 57 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.10463979 |
| 58 | mannosylation (GO:0097502) | 3.10334097 |
| 59 | regulation of dopamine metabolic process (GO:0042053) | 3.10205735 |
| 60 | regulation of catecholamine metabolic process (GO:0042069) | 3.10205735 |
| 61 | * protein targeting to ER (GO:0045047) | 3.10001198 |
| 62 | presynaptic membrane assembly (GO:0097105) | 3.09487069 |
| 63 | organelle disassembly (GO:1903008) | 3.08722576 |
| 64 | translational termination (GO:0006415) | 3.07901298 |
| 65 | regulation of mitochondrial translation (GO:0070129) | 3.05841669 |
| 66 | DNA deamination (GO:0045006) | 3.04587113 |
| 67 | inner mitochondrial membrane organization (GO:0007007) | 3.03512670 |
| 68 | * SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.03511249 |
| 69 | * protein localization to endoplasmic reticulum (GO:0070972) | 3.03251023 |
| 70 | protein-cofactor linkage (GO:0018065) | 3.02910284 |
| 71 | regulation of collateral sprouting (GO:0048670) | 3.02201543 |
| 72 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.02188125 |
| 73 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.02188125 |
| 74 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.02188125 |
| 75 | UTP biosynthetic process (GO:0006228) | 3.02036853 |
| 76 | pyrimidine nucleobase catabolic process (GO:0006208) | 2.99742124 |
| 77 | * establishment of protein localization to endoplasmic reticulum (GO:0072599) | 2.99319420 |
| 78 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.99046290 |
| 79 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.99046290 |
| 80 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 2.97508265 |
| 81 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 2.97441074 |
| 82 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.97421062 |
| 83 | termination of RNA polymerase III transcription (GO:0006386) | 2.97421062 |
| 84 | protein targeting to mitochondrion (GO:0006626) | 2.94831515 |
| 85 | oxidative phosphorylation (GO:0006119) | 2.94231168 |
| 86 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.93677399 |
| 87 | sterol biosynthetic process (GO:0016126) | 2.89804461 |
| 88 | chromatin remodeling at centromere (GO:0031055) | 2.89033320 |
| 89 | 7-methylguanosine mRNA capping (GO:0006370) | 2.88789239 |
| 90 | establishment of protein localization to mitochondrion (GO:0072655) | 2.88651264 |
| 91 | RNA capping (GO:0036260) | 2.88421940 |
| 92 | 7-methylguanosine RNA capping (GO:0009452) | 2.88421940 |
| 93 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.88416204 |
| 94 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.88263280 |
| 95 | GPI anchor metabolic process (GO:0006505) | 2.87529984 |
| 96 | dopamine transport (GO:0015872) | 2.86107943 |
| 97 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.85688802 |
| 98 | isoprenoid biosynthetic process (GO:0008299) | 2.83987714 |
| 99 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.83353071 |
| 100 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.83353071 |
| 101 | respiratory chain complex IV assembly (GO:0008535) | 2.82565094 |
| 102 | DNA double-strand break processing (GO:0000729) | 2.82502472 |
| 103 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.79646135 |
| 104 | CENP-A containing nucleosome assembly (GO:0034080) | 2.77878737 |
| 105 | cilium movement (GO:0003341) | 2.77462957 |
| 106 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.77411617 |
| 107 | nonmotile primary cilium assembly (GO:0035058) | 2.76604476 |
| 108 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 2.76375998 |
| 109 | translational elongation (GO:0006414) | 2.73211394 |
| 110 | negative regulation of protein localization to cell surface (GO:2000009) | 2.72765232 |
| 111 | calcium-mediated signaling using intracellular calcium source (GO:0035584) | 2.72182426 |
| 112 | mitochondrial fragmentation involved in apoptotic process (GO:0043653) | 2.72086833 |
| 113 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.71909041 |
| 114 | regulation of cilium movement (GO:0003352) | 2.70608643 |
| 115 | neural nucleus development (GO:0048857) | 2.69864095 |
| 116 | cullin deneddylation (GO:0010388) | 2.69841438 |
| 117 | neuron fate determination (GO:0048664) | 2.69767120 |
| 118 | * translation (GO:0006412) | 2.69197416 |
| 119 | glycerophospholipid catabolic process (GO:0046475) | 2.68608866 |
| 120 | anterograde synaptic vesicle transport (GO:0048490) | 2.67307239 |
| 121 | protein localization to mitochondrion (GO:0070585) | 2.66894296 |
| 122 | spliceosomal snRNP assembly (GO:0000387) | 2.66550508 |
| 123 | aldehyde catabolic process (GO:0046185) | 2.65800163 |
| 124 | guanosine-containing compound biosynthetic process (GO:1901070) | 2.65724992 |
| 125 | establishment of viral latency (GO:0019043) | 2.59529328 |
| 126 | negative regulation of neurotransmitter secretion (GO:0046929) | 2.58597338 |
| 127 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.58544349 |
| 128 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.58223669 |
| 129 | signal peptide processing (GO:0006465) | 2.57813668 |
| 130 | positive regulation of ligase activity (GO:0051351) | 2.56982288 |
| 131 | mitochondrial transport (GO:0006839) | 2.55620208 |
| 132 | cellular protein complex disassembly (GO:0043624) | 2.55266317 |
| 133 | viral life cycle (GO:0019058) | 2.55154328 |
| 134 | nucleoside diphosphate phosphorylation (GO:0006165) | 2.54854189 |
| 135 | nucleoside triphosphate biosynthetic process (GO:0009142) | 2.54658543 |
| 136 | negative regulation of execution phase of apoptosis (GO:1900118) | 2.53735795 |
| 137 | CTP biosynthetic process (GO:0006241) | 2.53565185 |
| 138 | CTP metabolic process (GO:0046036) | 2.53565185 |
| 139 | spliceosomal complex assembly (GO:0000245) | 2.53552879 |
| 140 | intracellular protein transmembrane import (GO:0044743) | 2.52681763 |
| 141 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.52581839 |
| 142 | negative regulation of ligase activity (GO:0051352) | 2.51994899 |
| 143 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.51994899 |
| 144 | ribosomal large subunit biogenesis (GO:0042273) | 2.51788311 |
| 145 | regulation of feeding behavior (GO:0060259) | 2.50976423 |
| 146 | protein deneddylation (GO:0000338) | 2.50735157 |
| 147 | oligodendrocyte differentiation (GO:0048709) | 2.49874200 |
| 148 | peptidyl-histidine modification (GO:0018202) | 2.49617442 |
| 149 | ribonucleoprotein complex disassembly (GO:0032988) | 2.49427456 |
| 150 | neurotransmitter uptake (GO:0001504) | 2.48987141 |
| 151 | negative regulation of transcription regulatory region DNA binding (GO:2000678) | 2.48941506 |
| 152 | protein localization to cilium (GO:0061512) | 2.48255722 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 5.10925337 |
| 2 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.57108645 |
| 3 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 3.23086480 |
| 4 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.06168001 |
| 5 | * GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.03242929 |
| 6 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.83590760 |
| 7 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.60762022 |
| 8 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.59321406 |
| 9 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.58383967 |
| 10 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.40358330 |
| 11 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.34613738 |
| 12 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.31913010 |
| 13 | VDR_22108803_ChIP-Seq_LS180_Human | 2.30717701 |
| 14 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.27762758 |
| 15 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.21662591 |
| 16 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.16852656 |
| 17 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 2.14624271 |
| 18 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.09710029 |
| 19 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.06750371 |
| 20 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.97063375 |
| 21 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.91303821 |
| 22 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.82321696 |
| 23 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 1.82248595 |
| 24 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.80464461 |
| 25 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 1.78722613 |
| 26 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.75449022 |
| 27 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.75078609 |
| 28 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.69810626 |
| 29 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.65262460 |
| 30 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.64249424 |
| 31 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.64156060 |
| 32 | FUS_26573619_Chip-Seq_HEK293_Human | 1.63738997 |
| 33 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.62487872 |
| 34 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.61241219 |
| 35 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 1.60850895 |
| 36 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.60360050 |
| 37 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.59522520 |
| 38 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.58490245 |
| 39 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.56716291 |
| 40 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.56589913 |
| 41 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.48971528 |
| 42 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.48355851 |
| 43 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.45986386 |
| 44 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.45461953 |
| 45 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.44620904 |
| 46 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.44556633 |
| 47 | * SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.41308464 |
| 48 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.38840593 |
| 49 | P300_19829295_ChIP-Seq_ESCs_Human | 1.38769748 |
| 50 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.38739580 |
| 51 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.36281535 |
| 52 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.35514066 |
| 53 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.33522108 |
| 54 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.33240034 |
| 55 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.32462941 |
| 56 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.31306916 |
| 57 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.31255799 |
| 58 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.28351655 |
| 59 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.28078215 |
| 60 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.27831886 |
| 61 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.27786141 |
| 62 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.27226685 |
| 63 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.26867326 |
| 64 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.25895772 |
| 65 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.25355459 |
| 66 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.24197588 |
| 67 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.24197588 |
| 68 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.24062284 |
| 69 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.23063820 |
| 70 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.21202906 |
| 71 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.20866189 |
| 72 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.20574514 |
| 73 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 1.20139670 |
| 74 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.20084916 |
| 75 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.20012731 |
| 76 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.18890925 |
| 77 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.18322841 |
| 78 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.15818139 |
| 79 | * GABP_19822575_ChIP-Seq_HepG2_Human | 1.13825985 |
| 80 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.13755270 |
| 81 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.12316569 |
| 82 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.12291683 |
| 83 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.11985467 |
| 84 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.09992312 |
| 85 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.09221341 |
| 86 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.07834742 |
| 87 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.06005219 |
| 88 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.05970333 |
| 89 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.05970333 |
| 90 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.05595056 |
| 91 | EWS_26573619_Chip-Seq_HEK293_Human | 1.04096837 |
| 92 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.03894440 |
| 93 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 1.03592513 |
| 94 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.02430591 |
| 95 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.02415918 |
| 96 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.00605128 |
| 97 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.00605128 |
| 98 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.00161047 |
| 99 | JUN_21703547_ChIP-Seq_K562_Human | 0.99627216 |
| 100 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 0.99189839 |
| 101 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.98957213 |
| 102 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 0.98284169 |
| 103 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.97414547 |
| 104 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.97414547 |
| 105 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.97174636 |
| 106 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.97028343 |
| 107 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 0.95799285 |
| 108 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.95644805 |
| 109 | AR_20517297_ChIP-Seq_VCAP_Human | 0.95113055 |
| 110 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.94733423 |
| 111 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.93292420 |
| 112 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.92990279 |
| 113 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.92816342 |
| 114 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.92751993 |
| 115 | AR_25329375_ChIP-Seq_VCAP_Human | 0.91996627 |
| 116 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.91706630 |
| 117 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.91533701 |
| 118 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.91460136 |
| 119 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.91240486 |
| 120 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.90969215 |
| 121 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.90675446 |
| 122 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.90631224 |
| 123 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.90631224 |
| 124 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.90542996 |
| 125 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 0.90362902 |
| 126 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.90359485 |
| 127 | REST_19997604_ChIP-ChIP_NEURONS_Mouse | 0.90253088 |
| 128 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.89901037 |
| 129 | * EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.89888825 |
| 130 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.89266327 |
| 131 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.87934303 |
| 132 | * DCP1A_22483619_ChIP-Seq_HELA_Human | 0.87690170 |
| 133 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.86739256 |
| 134 | * CMYC_18555785_Chip-Seq_ESCs_Mouse | 0.84160569 |
| 135 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.83874922 |
| 136 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 0.83807419 |
| 137 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 0.83405814 |
| 138 | EOMES_21245162_ChIP-Seq_HESCs_Human | 0.82828128 |
| 139 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 0.82603055 |
| 140 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 0.81669160 |
| 141 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.81644827 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003880_abnormal_central_pattern | 4.99873672 |
| 2 | MP0001529_abnormal_vocalization | 4.19830923 |
| 3 | MP0001905_abnormal_dopamine_level | 3.67562722 |
| 4 | MP0009379_abnormal_foot_pigmentation | 3.05408626 |
| 5 | MP0000920_abnormal_myelination | 2.94457234 |
| 6 | MP0006276_abnormal_autonomic_nervous | 2.75581325 |
| 7 | MP0004270_analgesia | 2.66856643 |
| 8 | MP0002272_abnormal_nervous_system | 2.34982549 |
| 9 | MP0008877_abnormal_DNA_methylation | 2.22038856 |
| 10 | MP0004142_abnormal_muscle_tone | 2.19329572 |
| 11 | MP0002064_seizures | 2.16032557 |
| 12 | MP0002734_abnormal_mechanical_nocicepti | 2.15972804 |
| 13 | MP0003011_delayed_dark_adaptation | 2.12398282 |
| 14 | MP0001968_abnormal_touch/_nociception | 2.11735816 |
| 15 | MP0005423_abnormal_somatic_nervous | 2.11557109 |
| 16 | MP0003136_yellow_coat_color | 2.11538349 |
| 17 | MP0005171_absent_coat_pigmentation | 2.06677215 |
| 18 | MP0001440_abnormal_grooming_behavior | 2.04553594 |
| 19 | MP0003787_abnormal_imprinting | 2.01606910 |
| 20 | MP0002736_abnormal_nociception_after | 2.00416422 |
| 21 | MP0005409_darkened_coat_color | 1.98327530 |
| 22 | MP0009745_abnormal_behavioral_response | 1.96806389 |
| 23 | MP0002653_abnormal_ependyma_morphology | 1.96012342 |
| 24 | MP0004133_heterotaxia | 1.94186822 |
| 25 | MP0002735_abnormal_chemical_nociception | 1.93915110 |
| 26 | MP0003121_genomic_imprinting | 1.92022887 |
| 27 | MP0001970_abnormal_pain_threshold | 1.91734214 |
| 28 | MP0008995_early_reproductive_senescence | 1.90845502 |
| 29 | MP0005084_abnormal_gallbladder_morpholo | 1.83673525 |
| 30 | MP0005410_abnormal_fertilization | 1.83652634 |
| 31 | MP0003635_abnormal_synaptic_transmissio | 1.82822940 |
| 32 | MP0002638_abnormal_pupillary_reflex | 1.82778368 |
| 33 | MP0004742_abnormal_vestibular_system | 1.81695044 |
| 34 | MP0008058_abnormal_DNA_repair | 1.79668590 |
| 35 | MP0001486_abnormal_startle_reflex | 1.78338340 |
| 36 | MP0005394_taste/olfaction_phenotype | 1.78101790 |
| 37 | MP0005499_abnormal_olfactory_system | 1.78101790 |
| 38 | MP0002572_abnormal_emotion/affect_behav | 1.75199600 |
| 39 | MP0002733_abnormal_thermal_nociception | 1.73083808 |
| 40 | MP0000778_abnormal_nervous_system | 1.72705687 |
| 41 | MP0001986_abnormal_taste_sensitivity | 1.72610130 |
| 42 | MP0009046_muscle_twitch | 1.70854436 |
| 43 | MP0005379_endocrine/exocrine_gland_phen | 1.62955657 |
| 44 | MP0003329_amyloid_beta_deposits | 1.56274068 |
| 45 | MP0002163_abnormal_gland_morphology | 1.52815999 |
| 46 | MP0000372_irregular_coat_pigmentation | 1.50183386 |
| 47 | MP0001293_anophthalmia | 1.49681836 |
| 48 | MP0001984_abnormal_olfaction | 1.47406095 |
| 49 | MP0001188_hyperpigmentation | 1.46995697 |
| 50 | MP0002063_abnormal_learning/memory/cond | 1.46269084 |
| 51 | MP0004859_abnormal_synaptic_plasticity | 1.44509179 |
| 52 | MP0003950_abnormal_plasma_membrane | 1.44325394 |
| 53 | MP0002067_abnormal_sensory_capabilities | 1.41423077 |
| 54 | MP0003634_abnormal_glial_cell | 1.38730081 |
| 55 | MP0002234_abnormal_pharynx_morphology | 1.37843346 |
| 56 | MP0005386_behavior/neurological_phenoty | 1.36831045 |
| 57 | MP0004924_abnormal_behavior | 1.36831045 |
| 58 | MP0006072_abnormal_retinal_apoptosis | 1.36686985 |
| 59 | MP0001485_abnormal_pinna_reflex | 1.35070723 |
| 60 | MP0010386_abnormal_urinary_bladder | 1.33750613 |
| 61 | MP0002184_abnormal_innervation | 1.31476278 |
| 62 | MP0005645_abnormal_hypothalamus_physiol | 1.26701701 |
| 63 | MP0002229_neurodegeneration | 1.25333622 |
| 64 | MP0010030_abnormal_orbit_morphology | 1.24924419 |
| 65 | MP0001727_abnormal_embryo_implantation | 1.24024000 |
| 66 | MP0001501_abnormal_sleep_pattern | 1.23738823 |
| 67 | MP0000049_abnormal_middle_ear | 1.23018307 |
| 68 | MP0003122_maternal_imprinting | 1.19978161 |
| 69 | MP0002938_white_spotting | 1.19262102 |
| 70 | MP0000566_synostosis | 1.17387093 |
| 71 | MP0005408_hypopigmentation | 1.16816831 |
| 72 | MP0003890_abnormal_embryonic-extraembry | 1.15400152 |
| 73 | MP0002882_abnormal_neuron_morphology | 1.14922167 |
| 74 | MP0003786_premature_aging | 1.14865369 |
| 75 | MP0004145_abnormal_muscle_electrophysio | 1.14482976 |
| 76 | MP0005551_abnormal_eye_electrophysiolog | 1.13316192 |
| 77 | MP0002837_dystrophic_cardiac_calcinosis | 1.12218500 |
| 78 | MP0002752_abnormal_somatic_nervous | 1.10457001 |
| 79 | MP0001963_abnormal_hearing_physiology | 1.09676654 |
| 80 | MP0002102_abnormal_ear_morphology | 1.09300272 |
| 81 | MP0002066_abnormal_motor_capabilities/c | 1.08924414 |
| 82 | MP0000955_abnormal_spinal_cord | 1.08852693 |
| 83 | MP0008872_abnormal_physiological_respon | 1.06818014 |
| 84 | MP0006036_abnormal_mitochondrial_physio | 1.06648449 |
| 85 | MP0003195_calcinosis | 1.05337231 |
| 86 | MP0003690_abnormal_glial_cell | 1.03752978 |
| 87 | MP0004381_abnormal_hair_follicle | 1.03596035 |
| 88 | MP0008260_abnormal_autophagy | 1.03425531 |
| 89 | MP0002822_catalepsy | 1.03024264 |
| 90 | MP0003567_abnormal_fetal_cardiomyocyte | 1.01428852 |
| 91 | MP0002233_abnormal_nose_morphology | 0.99176185 |
| 92 | MP0002295_abnormal_pulmonary_circulatio | 0.97262781 |
| 93 | MP0005646_abnormal_pituitary_gland | 0.96837945 |
| 94 | MP0002277_abnormal_respiratory_mucosa | 0.96663477 |
| 95 | MP0003937_abnormal_limbs/digits/tail_de | 0.96364023 |
| 96 | MP0005187_abnormal_penis_morphology | 0.96312493 |
| 97 | MP0008875_abnormal_xenobiotic_pharmacok | 0.94183212 |
| 98 | MP0002282_abnormal_trachea_morphology | 0.94171566 |
| 99 | MP0002557_abnormal_social/conspecific_i | 0.94129473 |
| 100 | MP0009697_abnormal_copulation | 0.93597264 |
| 101 | MP0002876_abnormal_thyroid_physiology | 0.93526682 |
| 102 | MP0000647_abnormal_sebaceous_gland | 0.93092978 |
| 103 | MP0001502_abnormal_circadian_rhythm | 0.93009782 |
| 104 | MP0000631_abnormal_neuroendocrine_gland | 0.92128746 |
| 105 | MP0005391_vision/eye_phenotype | 0.91940770 |
| 106 | MP0002751_abnormal_autonomic_nervous | 0.90134615 |
| 107 | MP0001764_abnormal_homeostasis | 0.89977449 |
| 108 | MP0003119_abnormal_digestive_system | 0.89193574 |
| 109 | MP0004134_abnormal_chest_morphology | 0.88711773 |
| 110 | MP0000026_abnormal_inner_ear | 0.88678025 |
| 111 | MP0003315_abnormal_perineum_morphology | 0.88183134 |
| 112 | MP0003632_abnormal_nervous_system | 0.86643052 |
| 113 | MP0004215_abnormal_myocardial_fiber | 0.86168030 |
| 114 | MP0001286_abnormal_eye_development | 0.84937959 |
| 115 | MP0006035_abnormal_mitochondrial_morpho | 0.84343511 |
| 116 | MP0002210_abnormal_sex_determination | 0.84047754 |
| 117 | MP0003137_abnormal_impulse_conducting | 0.83859931 |
| 118 | MP0005253_abnormal_eye_physiology | 0.82920554 |
| 119 | MP0001324_abnormal_eye_pigmentation | 0.79066020 |
| 120 | MP0002090_abnormal_vision | 0.78788151 |
| 121 | MP0005451_abnormal_body_composition | 0.77866349 |
| 122 | MP0003631_nervous_system_phenotype | 0.76613527 |
| 123 | MP0004147_increased_porphyrin_level | 0.76022107 |
| 124 | MP0006292_abnormal_olfactory_placode | 0.74900297 |
| 125 | MP0001542_abnormal_bone_strength | 0.74290192 |
| 126 | MP0004043_abnormal_pH_regulation | 0.73654034 |
| 127 | MP0003938_abnormal_ear_development | 0.71764696 |
| 128 | MP0003718_maternal_effect | 0.71608168 |
| 129 | MP0001346_abnormal_lacrimal_gland | 0.69966472 |
| 130 | MP0001664_abnormal_digestion | 0.69280104 |
| 131 | MP0005195_abnormal_posterior_eye | 0.66680099 |
| 132 | MP0008569_lethality_at_weaning | 0.65698375 |
| 133 | MP0000462_abnormal_digestive_system | 0.65599395 |
| 134 | MP0008789_abnormal_olfactory_epithelium | 0.63669469 |
| 135 | MP0002152_abnormal_brain_morphology | 0.63393218 |
| 136 | MP0003186_abnormal_redox_activity | 0.61574128 |
| 137 | MP0006082_CNS_inflammation | 0.61413340 |
| 138 | MP0004036_abnormal_muscle_relaxation | 0.61358627 |
| 139 | MP0004885_abnormal_endolymph | 0.59629861 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.97102979 |
| 2 | Mitochondrial inheritance (HP:0001427) | 5.20013391 |
| 3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 5.19405952 |
| 4 | Progressive macrocephaly (HP:0004481) | 5.00830789 |
| 5 | Acute encephalopathy (HP:0006846) | 4.68846289 |
| 6 | Increased hepatocellular lipid droplets (HP:0006565) | 4.53903152 |
| 7 | Renal Fanconi syndrome (HP:0001994) | 4.36438528 |
| 8 | Hepatocellular necrosis (HP:0001404) | 4.19439756 |
| 9 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 4.18204744 |
| 10 | Increased CSF lactate (HP:0002490) | 4.11941082 |
| 11 | Abnormality of glycolysis (HP:0004366) | 3.99355411 |
| 12 | Increased serum pyruvate (HP:0003542) | 3.99355411 |
| 13 | Parakeratosis (HP:0001036) | 3.93148703 |
| 14 | Lipid accumulation in hepatocytes (HP:0006561) | 3.87068591 |
| 15 | 3-Methylglutaconic aciduria (HP:0003535) | 3.84574664 |
| 16 | Leukodystrophy (HP:0002415) | 3.66724440 |
| 17 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 3.53449866 |
| 18 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 3.53449866 |
| 19 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.46257960 |
| 20 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.43244960 |
| 21 | True hermaphroditism (HP:0010459) | 3.36419597 |
| 22 | Pancreatic fibrosis (HP:0100732) | 3.35877120 |
| 23 | Hepatic necrosis (HP:0002605) | 3.32994340 |
| 24 | Pancreatic cysts (HP:0001737) | 3.31542052 |
| 25 | Sensory axonal neuropathy (HP:0003390) | 3.26656970 |
| 26 | Molar tooth sign on MRI (HP:0002419) | 3.25643187 |
| 27 | Abnormality of midbrain morphology (HP:0002418) | 3.25643187 |
| 28 | Optic disc pallor (HP:0000543) | 3.19102331 |
| 29 | Neurofibrillary tangles (HP:0002185) | 3.17485319 |
| 30 | Increased intramyocellular lipid droplets (HP:0012240) | 3.14116060 |
| 31 | Exertional dyspnea (HP:0002875) | 2.95592847 |
| 32 | Respiratory failure (HP:0002878) | 2.95028963 |
| 33 | Nephronophthisis (HP:0000090) | 2.94244314 |
| 34 | Myokymia (HP:0002411) | 2.89415895 |
| 35 | Hypothermia (HP:0002045) | 2.87680713 |
| 36 | Exercise intolerance (HP:0003546) | 2.85639919 |
| 37 | Abnormality of renal resorption (HP:0011038) | 2.84848890 |
| 38 | Medial flaring of the eyebrow (HP:0010747) | 2.77221539 |
| 39 | Neuroendocrine neoplasm (HP:0100634) | 2.75472754 |
| 40 | Cerebral hypomyelination (HP:0006808) | 2.74444401 |
| 41 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.72969617 |
| 42 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.72969617 |
| 43 | Retinal dysplasia (HP:0007973) | 2.72432098 |
| 44 | Cerebral edema (HP:0002181) | 2.72249044 |
| 45 | Congenital, generalized hypertrichosis (HP:0004540) | 2.70792562 |
| 46 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.68657490 |
| 47 | Pheochromocytoma (HP:0002666) | 2.60561622 |
| 48 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.57797594 |
| 49 | Gait imbalance (HP:0002141) | 2.51944714 |
| 50 | Abnormality of the labia minora (HP:0012880) | 2.51436303 |
| 51 | Lactic acidosis (HP:0003128) | 2.51327185 |
| 52 | Limb dystonia (HP:0002451) | 2.49531349 |
| 53 | Increased muscle lipid content (HP:0009058) | 2.44835344 |
| 54 | Vaginal atresia (HP:0000148) | 2.40390659 |
| 55 | Congenital primary aphakia (HP:0007707) | 2.39918939 |
| 56 | Hyperglycinemia (HP:0002154) | 2.39245305 |
| 57 | Genital tract atresia (HP:0001827) | 2.34578260 |
| 58 | Increased serum lactate (HP:0002151) | 2.33137341 |
| 59 | Abnormality of the corticospinal tract (HP:0002492) | 2.32631176 |
| 60 | Sclerocornea (HP:0000647) | 2.31320397 |
| 61 | Respiratory difficulties (HP:0002880) | 2.30625802 |
| 62 | Cerebral inclusion bodies (HP:0100314) | 2.30594870 |
| 63 | Abnormality of the renal medulla (HP:0100957) | 2.28998210 |
| 64 | Septo-optic dysplasia (HP:0100842) | 2.28886423 |
| 65 | Colon cancer (HP:0003003) | 2.28119474 |
| 66 | Peripheral hypomyelination (HP:0007182) | 2.26394085 |
| 67 | Cerebral hemorrhage (HP:0001342) | 2.24533047 |
| 68 | Abnormal ciliary motility (HP:0012262) | 2.23521009 |
| 69 | Nephrogenic diabetes insipidus (HP:0009806) | 2.22604013 |
| 70 | X-linked dominant inheritance (HP:0001423) | 2.19445267 |
| 71 | Atonic seizures (HP:0010819) | 2.19217853 |
| 72 | Methylmalonic aciduria (HP:0012120) | 2.17824894 |
| 73 | Lethargy (HP:0001254) | 2.15701461 |
| 74 | Reticulocytopenia (HP:0001896) | 2.15533713 |
| 75 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.15289951 |
| 76 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.13637689 |
| 77 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.13637689 |
| 78 | Absent/shortened dynein arms (HP:0200106) | 2.13111778 |
| 79 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.13111778 |
| 80 | Focal motor seizures (HP:0011153) | 2.07603503 |
| 81 | Abnormal number of erythroid precursors (HP:0012131) | 2.06582053 |
| 82 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 2.02747889 |
| 83 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.02302722 |
| 84 | Abnormal pupillary function (HP:0007686) | 2.01457950 |
| 85 | Anencephaly (HP:0002323) | 1.98891208 |
| 86 | Supranuclear gaze palsy (HP:0000605) | 1.97423461 |
| 87 | CNS hypomyelination (HP:0003429) | 1.97354973 |
| 88 | Renal cortical cysts (HP:0000803) | 1.97130704 |
| 89 | Delusions (HP:0000746) | 1.96479789 |
| 90 | Male pseudohermaphroditism (HP:0000037) | 1.95608152 |
| 91 | Concave nail (HP:0001598) | 1.95564209 |
| 92 | Abnormality of the renal cortex (HP:0011035) | 1.93520960 |
| 93 | Abnormal hair whorl (HP:0010721) | 1.92693650 |
| 94 | Autoamputation (HP:0001218) | 1.92658014 |
| 95 | Congenital stationary night blindness (HP:0007642) | 1.92060300 |
| 96 | Abnormality of the anterior horn cell (HP:0006802) | 1.91680720 |
| 97 | Degeneration of anterior horn cells (HP:0002398) | 1.91680720 |
| 98 | Macrocytic anemia (HP:0001972) | 1.90443144 |
| 99 | Cystic liver disease (HP:0006706) | 1.87653678 |
| 100 | Aplastic anemia (HP:0001915) | 1.87430737 |
| 101 | Postaxial hand polydactyly (HP:0001162) | 1.87402659 |
| 102 | Postaxial foot polydactyly (HP:0001830) | 1.86484059 |
| 103 | Abolished electroretinogram (ERG) (HP:0000550) | 1.85939794 |
| 104 | Stenosis of the external auditory canal (HP:0000402) | 1.85442606 |
| 105 | Anophthalmia (HP:0000528) | 1.83797597 |
| 106 | Chronic hepatic failure (HP:0100626) | 1.83599033 |
| 107 | Spastic paraparesis (HP:0002313) | 1.83157087 |
| 108 | Emotional lability (HP:0000712) | 1.82965428 |
| 109 | Abnormal autonomic nervous system physiology (HP:0012332) | 1.81396115 |
| 110 | Abnormality of placental membranes (HP:0011409) | 1.80783003 |
| 111 | Amniotic constriction ring (HP:0009775) | 1.80783003 |
| 112 | Generalized aminoaciduria (HP:0002909) | 1.79674157 |
| 113 | Esotropia (HP:0000565) | 1.77841011 |
| 114 | Patchy hypopigmentation of hair (HP:0011365) | 1.77203340 |
| 115 | Optic nerve hypoplasia (HP:0000609) | 1.77091467 |
| 116 | Short tibia (HP:0005736) | 1.76380020 |
| 117 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.75517012 |
| 118 | Hyperphosphaturia (HP:0003109) | 1.75002410 |
| 119 | Occipital encephalocele (HP:0002085) | 1.74864929 |
| 120 | Akinesia (HP:0002304) | 1.74383268 |
| 121 | Intestinal atresia (HP:0011100) | 1.74348745 |
| 122 | Supernumerary spleens (HP:0009799) | 1.73216291 |
| 123 | Congenital hepatic fibrosis (HP:0002612) | 1.72008081 |
| 124 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.68638733 |
| 125 | Type II lissencephaly (HP:0007260) | 1.68315239 |
| 126 | CNS demyelination (HP:0007305) | 1.67912372 |
| 127 | Adrenal hypoplasia (HP:0000835) | 1.66732609 |
| 128 | Progressive inability to walk (HP:0002505) | 1.65012922 |
| 129 | Aplasia/Hypoplasia of the lens (HP:0008063) | 1.62627427 |
| 130 | Poor suck (HP:0002033) | 1.60883365 |
| 131 | Rhinitis (HP:0012384) | 1.60592255 |
| 132 | Spastic gait (HP:0002064) | 1.58954740 |
| 133 | Abnormality of secondary sexual hair (HP:0009888) | 1.58044556 |
| 134 | Abnormality of the axillary hair (HP:0100134) | 1.58044556 |
| 135 | Postnatal microcephaly (HP:0005484) | 1.57773408 |
| 136 | Hypoplastic pelvis (HP:0008839) | 1.56738214 |
| 137 | Glycosuria (HP:0003076) | 1.56171100 |
| 138 | Abnormality of urine glucose concentration (HP:0011016) | 1.56171100 |
| 139 | Dialeptic seizures (HP:0011146) | 1.54868629 |
| 140 | Polyphagia (HP:0002591) | 1.54789757 |
| 141 | White forelock (HP:0002211) | 1.54417027 |
| 142 | Methylmalonic acidemia (HP:0002912) | 1.53764851 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | STK39 | 3.94406326 |
| 2 | ARAF | 3.05152532 |
| 3 | MAP4K2 | 2.90351784 |
| 4 | VRK2 | 2.87613757 |
| 5 | OXSR1 | 2.84783506 |
| 6 | MAP3K12 | 2.78590165 |
| 7 | MST4 | 2.54890376 |
| 8 | PNCK | 2.42502234 |
| 9 | TRIM28 | 2.40658061 |
| 10 | STK16 | 2.37218506 |
| 11 | BCR | 2.37075950 |
| 12 | MAPKAPK5 | 2.25058640 |
| 13 | TNIK | 2.24443949 |
| 14 | PBK | 2.21963593 |
| 15 | NME1 | 2.17135591 |
| 16 | CDK19 | 2.08742192 |
| 17 | LIMK1 | 2.06344412 |
| 18 | CASK | 2.04661297 |
| 19 | NME2 | 1.98279245 |
| 20 | MUSK | 1.94876773 |
| 21 | BCKDK | 1.91745250 |
| 22 | ZAK | 1.89024452 |
| 23 | WNK4 | 1.84589145 |
| 24 | GRK5 | 1.84396080 |
| 25 | NUAK1 | 1.81793105 |
| 26 | GRK7 | 1.66366842 |
| 27 | BMPR1B | 1.65661235 |
| 28 | CSNK1G3 | 1.65226551 |
| 29 | PINK1 | 1.50614047 |
| 30 | DYRK3 | 1.47147454 |
| 31 | DYRK2 | 1.45699686 |
| 32 | FGR | 1.45358029 |
| 33 | UHMK1 | 1.43743836 |
| 34 | INSRR | 1.40498716 |
| 35 | WEE1 | 1.35953914 |
| 36 | BUB1 | 1.35951108 |
| 37 | CAMK2B | 1.35887489 |
| 38 | CDC7 | 1.33548121 |
| 39 | ERBB3 | 1.32742681 |
| 40 | VRK1 | 1.32442261 |
| 41 | PKN1 | 1.32219893 |
| 42 | ADRBK2 | 1.26039378 |
| 43 | PLK3 | 1.25733782 |
| 44 | NTRK1 | 1.24313606 |
| 45 | MAPK13 | 1.19719749 |
| 46 | NEK1 | 1.17998050 |
| 47 | MARK1 | 1.17614771 |
| 48 | BMPR2 | 1.16567035 |
| 49 | CSNK1G1 | 1.13745982 |
| 50 | TESK2 | 1.13305506 |
| 51 | MYLK | 1.12757781 |
| 52 | CSNK1G2 | 1.12714218 |
| 53 | PIM2 | 1.11667192 |
| 54 | PLK4 | 1.10667316 |
| 55 | FRK | 1.10399292 |
| 56 | EPHB1 | 1.08454794 |
| 57 | CSNK1A1L | 1.05200555 |
| 58 | CAMK2D | 1.04882033 |
| 59 | NEK6 | 1.03456074 |
| 60 | MKNK2 | 1.03152918 |
| 61 | MET | 1.02263716 |
| 62 | EIF2AK3 | 1.00068168 |
| 63 | PLK2 | 0.99683405 |
| 64 | MAP2K7 | 0.99126958 |
| 65 | BRAF | 0.99108371 |
| 66 | ROCK2 | 0.98217306 |
| 67 | CAMK2A | 0.95788154 |
| 68 | NTRK3 | 0.86880542 |
| 69 | CAMK2G | 0.86183582 |
| 70 | EIF2AK1 | 0.83513518 |
| 71 | EPHA4 | 0.83372142 |
| 72 | CDK14 | 0.82627925 |
| 73 | TXK | 0.76332815 |
| 74 | KDR | 0.76197060 |
| 75 | PLK1 | 0.75385831 |
| 76 | PRKCE | 0.73227752 |
| 77 | IRAK2 | 0.73099168 |
| 78 | RIPK4 | 0.71775292 |
| 79 | TSSK6 | 0.71498394 |
| 80 | PTK2B | 0.71141264 |
| 81 | ADRBK1 | 0.70220429 |
| 82 | MAPK15 | 0.69869348 |
| 83 | TIE1 | 0.69032358 |
| 84 | MOS | 0.68320192 |
| 85 | CDK18 | 0.67289143 |
| 86 | CDK15 | 0.66614133 |
| 87 | ABL2 | 0.65080007 |
| 88 | CDK11A | 0.64177640 |
| 89 | RPS6KA5 | 0.63446145 |
| 90 | RAF1 | 0.62608664 |
| 91 | MAP3K9 | 0.62548933 |
| 92 | CDK5 | 0.60315784 |
| 93 | BRSK2 | 0.60261654 |
| 94 | FES | 0.58823313 |
| 95 | EPHB2 | 0.58014992 |
| 96 | KSR2 | 0.57940521 |
| 97 | GRK1 | 0.57517935 |
| 98 | NTRK2 | 0.55172786 |
| 99 | CSNK2A1 | 0.55040664 |
| 100 | OBSCN | 0.54328401 |
| 101 | RPS6KA4 | 0.53695758 |
| 102 | IRAK1 | 0.52748455 |
| 103 | MAP3K4 | 0.49817241 |
| 104 | CAMKK2 | 0.49548337 |
| 105 | CSNK2A2 | 0.49073684 |
| 106 | PDK2 | 0.48109558 |
| 107 | CSNK1A1 | 0.46833397 |
| 108 | AURKB | 0.46778312 |
| 109 | PASK | 0.46777748 |
| 110 | ATR | 0.46760519 |
| 111 | ILK | 0.46499861 |
| 112 | PAK3 | 0.45531301 |
| 113 | WNK1 | 0.45491806 |
| 114 | PAK1 | 0.45059820 |
| 115 | TAF1 | 0.44982491 |
| 116 | SRPK1 | 0.44075050 |
| 117 | PRKACA | 0.43787026 |
| 118 | ACVR1B | 0.43024291 |
| 119 | DAPK3 | 0.42542581 |
| 120 | TESK1 | 0.42133009 |
| 121 | CDK3 | 0.42000189 |
| 122 | TGFBR1 | 0.41992950 |
| 123 | PRPF4B | 0.41741716 |
| 124 | WNK3 | 0.41737994 |
| 125 | PRKCQ | 0.41495160 |
| 126 | MAP2K4 | 0.40760607 |
| 127 | PRKCG | 0.40542404 |
| 128 | TAOK3 | 0.40201090 |
| 129 | DAPK1 | 0.38537122 |
| 130 | STK38L | 0.38044615 |
| 131 | MINK1 | 0.37940099 |
| 132 | DYRK1B | 0.36717922 |
| 133 | PRKG1 | 0.34306790 |
| 134 | DYRK1A | 0.33510688 |
| 135 | TLK1 | 0.32201759 |
| 136 | PHKG1 | 0.31809168 |
| 137 | PHKG2 | 0.31809168 |
| 138 | CDK8 | 0.31007298 |
| 139 | MAP3K13 | 0.29046165 |
| 140 | IRAK4 | 0.29040349 |
| 141 | PAK6 | 0.28762759 |
| 142 | MKNK1 | 0.27969687 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 5.67915585 |
| 2 | Parkinsons disease_Homo sapiens_hsa05012 | 4.65602497 |
| 3 | Alzheimers disease_Homo sapiens_hsa05010 | 3.67598041 |
| 4 | Proteasome_Homo sapiens_hsa03050 | 3.39965917 |
| 5 | Ribosome_Homo sapiens_hsa03010 | 3.36820918 |
| 6 | Huntingtons disease_Homo sapiens_hsa05016 | 3.31421288 |
| 7 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 3.30314397 |
| 8 | * Protein export_Homo sapiens_hsa03060 | 3.05369341 |
| 9 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.80317307 |
| 10 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.42250072 |
| 11 | RNA polymerase_Homo sapiens_hsa03020 | 2.32276626 |
| 12 | Fatty acid elongation_Homo sapiens_hsa00062 | 2.16108106 |
| 13 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.09101867 |
| 14 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.02175987 |
| 15 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.99873257 |
| 16 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.95192586 |
| 17 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.82765316 |
| 18 | Homologous recombination_Homo sapiens_hsa03440 | 1.69732914 |
| 19 | Mismatch repair_Homo sapiens_hsa03430 | 1.69625692 |
| 20 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.62284420 |
| 21 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.60063723 |
| 22 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.55305147 |
| 23 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.39784403 |
| 24 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.35495044 |
| 25 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.35014483 |
| 26 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.34638897 |
| 27 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.32054788 |
| 28 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.31953719 |
| 29 | Nicotine addiction_Homo sapiens_hsa05033 | 1.29398597 |
| 30 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.28118248 |
| 31 | DNA replication_Homo sapiens_hsa03030 | 1.17286483 |
| 32 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.15979591 |
| 33 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 1.15509330 |
| 34 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.14035051 |
| 35 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.06671921 |
| 36 | Peroxisome_Homo sapiens_hsa04146 | 1.05616885 |
| 37 | Base excision repair_Homo sapiens_hsa03410 | 1.05282412 |
| 38 | Basal transcription factors_Homo sapiens_hsa03022 | 1.02307854 |
| 39 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.00803642 |
| 40 | Phototransduction_Homo sapiens_hsa04744 | 0.95894917 |
| 41 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.95072898 |
| 42 | GABAergic synapse_Homo sapiens_hsa04727 | 0.93998338 |
| 43 | RNA transport_Homo sapiens_hsa03013 | 0.93560417 |
| 44 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.92192407 |
| 45 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.91908592 |
| 46 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.91351008 |
| 47 | Phagosome_Homo sapiens_hsa04145 | 0.91080194 |
| 48 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.88784355 |
| 49 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.87374255 |
| 50 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.86218833 |
| 51 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.85446806 |
| 52 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.82599745 |
| 53 | Taste transduction_Homo sapiens_hsa04742 | 0.81132898 |
| 54 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.80204800 |
| 55 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.79466105 |
| 56 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.78955348 |
| 57 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.78090981 |
| 58 | Morphine addiction_Homo sapiens_hsa05032 | 0.77954449 |
| 59 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.77838559 |
| 60 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.76058818 |
| 61 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.75460073 |
| 62 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.75441965 |
| 63 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.72274983 |
| 64 | Long-term depression_Homo sapiens_hsa04730 | 0.72124284 |
| 65 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.71361818 |
| 66 | Cocaine addiction_Homo sapiens_hsa05030 | 0.70852140 |
| 67 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.69038506 |
| 68 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.67647411 |
| 69 | Metabolic pathways_Homo sapiens_hsa01100 | 0.65778173 |
| 70 | Purine metabolism_Homo sapiens_hsa00230 | 0.65730085 |
| 71 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.63965671 |
| 72 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.62534664 |
| 73 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.62379966 |
| 74 | Circadian entrainment_Homo sapiens_hsa04713 | 0.61776334 |
| 75 | Axon guidance_Homo sapiens_hsa04360 | 0.61222418 |
| 76 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.61189997 |
| 77 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.60675600 |
| 78 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.60660714 |
| 79 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.60566930 |
| 80 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.59742761 |
| 81 | Retinol metabolism_Homo sapiens_hsa00830 | 0.56152364 |
| 82 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.55447307 |
| 83 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.54544531 |
| 84 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.51159830 |
| 85 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.50875478 |
| 86 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.50696285 |
| 87 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.49628495 |
| 88 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.47528526 |
| 89 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.47080258 |
| 90 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.46654408 |
| 91 | Asthma_Homo sapiens_hsa05310 | 0.46227386 |
| 92 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.45339477 |
| 93 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.44279488 |
| 94 | Histidine metabolism_Homo sapiens_hsa00340 | 0.43396422 |
| 95 | Alcoholism_Homo sapiens_hsa05034 | 0.43196742 |
| 96 | Sulfur relay system_Homo sapiens_hsa04122 | 0.42922988 |
| 97 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.42342370 |
| 98 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.40953454 |
| 99 | Allograft rejection_Homo sapiens_hsa05330 | 0.40290494 |
| 100 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.40047670 |
| 101 | Olfactory transduction_Homo sapiens_hsa04740 | 0.39888339 |
| 102 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.39175554 |
| 103 | Renin secretion_Homo sapiens_hsa04924 | 0.39169694 |
| 104 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.38770905 |
| 105 | Long-term potentiation_Homo sapiens_hsa04720 | 0.37844712 |
| 106 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.37441287 |
| 107 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.36705114 |
| 108 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.36381188 |
| 109 | Spliceosome_Homo sapiens_hsa03040 | 0.35330434 |
| 110 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.35065756 |
| 111 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.33730146 |
| 112 | Salivary secretion_Homo sapiens_hsa04970 | 0.33546523 |
| 113 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.32171805 |
| 114 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.32033741 |
| 115 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.31889887 |
| 116 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.30612935 |
| 117 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.30077550 |
| 118 | Carbon metabolism_Homo sapiens_hsa01200 | 0.29318308 |
| 119 | Lysosome_Homo sapiens_hsa04142 | 0.27845430 |
| 120 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.27659242 |
| 121 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.27021755 |
| 122 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.24983864 |
| 123 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.24757930 |
| 124 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.23744457 |
| 125 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.22001574 |
| 126 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.20639283 |
| 127 | RNA degradation_Homo sapiens_hsa03018 | 0.20420740 |
| 128 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.20357749 |
| 129 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.19746621 |
| 130 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.17980434 |
| 131 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.17772828 |
| 132 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.17580403 |
| 133 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.17199041 |
| 134 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.16838200 |
| 135 | Insulin secretion_Homo sapiens_hsa04911 | 0.16434311 |
| 136 | Gap junction_Homo sapiens_hsa04540 | 0.16033609 |
| 137 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.15342304 |
| 138 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.14828341 |
| 139 | Malaria_Homo sapiens_hsa05144 | 0.14449164 |
| 140 | Endocytosis_Homo sapiens_hsa04144 | 0.11734225 |
| 141 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.11413788 |

