SRP54

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)4.85563049
2COPII vesicle coating (GO:0048208)4.67123421
3Golgi transport vesicle coating (GO:0048200)4.46704625
4COPI coating of Golgi vesicle (GO:0048205)4.46704625
5ribosome assembly (GO:0042255)4.37852087
6negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.00758931
7regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.90542928
8positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.90440770
9establishment of integrated proviral latency (GO:0075713)3.87543778
10establishment of viral latency (GO:0019043)3.85735100
11ER overload response (GO:0006983)3.76642007
12regulation of cellular amino acid metabolic process (GO:0006521)3.73195974
13DNA damage response, detection of DNA damage (GO:0042769)3.67449943
14negative regulation of ligase activity (GO:0051352)3.66195730
15negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.66195730
16tRNA aminoacylation for protein translation (GO:0006418)3.63551712
17anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.63205490
18regulation of centriole replication (GO:0046599)3.58426850
19DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.56009051
20tRNA aminoacylation (GO:0043039)3.52860256
21amino acid activation (GO:0043038)3.52860256
22signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.52334439
23signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.52334439
24signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.52334439
25intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.52048914
26signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.52048914
27signal transduction involved in DNA integrity checkpoint (GO:0072401)3.40087488
28signal transduction involved in DNA damage checkpoint (GO:0072422)3.40087488
29signal transduction involved in cell cycle checkpoint (GO:0072395)3.35388909
30cullin deneddylation (GO:0010388)3.35161798
31mitotic metaphase plate congression (GO:0007080)3.30613118
32positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.28468623
33cholesterol biosynthetic process (GO:0006695)3.25546703
34CENP-A containing nucleosome assembly (GO:0034080)3.24413911
35rRNA modification (GO:0000154)3.22159294
36rRNA methylation (GO:0031167)3.19579990
377-methylguanosine mRNA capping (GO:0006370)3.18987839
38non-recombinational repair (GO:0000726)3.17044855
39double-strand break repair via nonhomologous end joining (GO:0006303)3.17044855
40nuclear pore complex assembly (GO:0051292)3.12943709
41positive regulation of ligase activity (GO:0051351)3.12595394
42metaphase plate congression (GO:0051310)3.12590205
43nucleotide-sugar biosynthetic process (GO:0009226)3.10811085
44chromatin remodeling at centromere (GO:0031055)3.10567727
45RNA capping (GO:0036260)3.08439848
467-methylguanosine RNA capping (GO:0009452)3.08439848
47DNA ligation (GO:0006266)3.08237080
48sterol biosynthetic process (GO:0016126)3.03522986
49synapsis (GO:0007129)3.01684695
50protein deneddylation (GO:0000338)3.01051358
51regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.98015915
52regulation of meiosis I (GO:0060631)2.95315013
53histone exchange (GO:0043486)2.94391747
54regulation of ubiquitin-protein transferase activity (GO:0051438)2.93499650
55establishment of protein localization to mitochondrial membrane (GO:0090151)2.92348465
56maturation of 5.8S rRNA (GO:0000460)2.91856936
57tricarboxylic acid cycle (GO:0006099)2.91226335
58ER to Golgi vesicle-mediated transport (GO:0006888)2.89004181
59resolution of meiotic recombination intermediates (GO:0000712)2.86590870
60dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.82987923
61formation of translation preinitiation complex (GO:0001731)2.82681889
62respiratory chain complex IV assembly (GO:0008535)2.82585152
63regulation of ligase activity (GO:0051340)2.81634052
64ribosome biogenesis (GO:0042254)2.79964914
65ribonucleoprotein complex disassembly (GO:0032988)2.78376129
66mitotic sister chromatid cohesion (GO:0007064)2.74913153
67negative regulation of protein ubiquitination (GO:0031397)2.72725793
68nuclear pore organization (GO:0006999)2.69851965
69folic acid-containing compound biosynthetic process (GO:0009396)2.69840607
70regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.68913869
71regulation of mitotic spindle checkpoint (GO:1903504)2.68913869
72spliceosomal snRNP assembly (GO:0000387)2.67927542
73activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.67699149
74G1/S transition of mitotic cell cycle (GO:0000082)2.67357961
75cell cycle G1/S phase transition (GO:0044843)2.67357961
76purine nucleobase biosynthetic process (GO:0009113)2.66460108
77protein localization to kinetochore (GO:0034501)2.66042495
78histone mRNA metabolic process (GO:0008334)2.65673973
79establishment of chromosome localization (GO:0051303)2.65145406
80DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.64996837
81organelle disassembly (GO:1903008)2.64070331
82pteridine-containing compound biosynthetic process (GO:0042559)2.63738004
83regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.62725018
84antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.62663092
85DNA replication-independent nucleosome organization (GO:0034724)2.60435364
86DNA replication-independent nucleosome assembly (GO:0006336)2.60435364
87regulation of DNA endoreduplication (GO:0032875)2.60401142
88vesicle coating (GO:0006901)2.60333682
89kinetochore organization (GO:0051383)2.59692747
90regulation of cellular amine metabolic process (GO:0033238)2.58392039
91mitotic spindle checkpoint (GO:0071174)2.58268787
92positive regulation of cell cycle arrest (GO:0071158)2.58025236
93regulation of translation in response to stress (GO:0043555)2.58008010
94DNA double-strand break processing (GO:0000729)2.57520468
95mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.56366123
96protein refolding (GO:0042026)2.55514847
97mitotic nuclear envelope disassembly (GO:0007077)2.54856700
98telomere maintenance via semi-conservative replication (GO:0032201)2.54570826
99negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.52840216
100spindle checkpoint (GO:0031577)2.52150567

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.78835768
2* GABP_17652178_ChIP-ChIP_JURKAT_Human4.19757166
3E2F7_22180533_ChIP-Seq_HELA_Human3.67017500
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.37398042
5* CREB1_15753290_ChIP-ChIP_HEK293T_Human3.32957181
6ELK1_19687146_ChIP-ChIP_HELA_Human3.16930326
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.89360891
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.85164116
9PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.84090306
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.75244785
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.73949923
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.73725184
13* ETS1_20019798_ChIP-Seq_JURKAT_Human2.55530586
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.55283810
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.49550678
16* PADI4_21655091_ChIP-ChIP_MCF-7_Human2.48791589
17VDR_23849224_ChIP-Seq_CD4+_Human2.48237458
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.39946804
19DCP1A_22483619_ChIP-Seq_HELA_Human2.39018952
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.33200098
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.31932200
22FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.23187788
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17058668
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.13716605
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.12066774
26MYCN_18555785_ChIP-Seq_MESCs_Mouse2.07919800
27AR_21909140_ChIP-Seq_LNCAP_Human2.05718686
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.01519560
29* FOXP3_21729870_ChIP-Seq_TREG_Human2.00197654
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98511195
31PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.94302691
32* GABP_19822575_ChIP-Seq_HepG2_Human1.93173631
33HOXB4_20404135_ChIP-ChIP_EML_Mouse1.85676558
34* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.84633171
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80219689
36EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.79585564
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78124152
38* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.75167125
39HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.72406738
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.71285357
41RBPJ_22232070_ChIP-Seq_NCS_Mouse1.69336308
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69039282
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.60844714
44ZNF274_21170338_ChIP-Seq_K562_Hela1.60508525
45TTF2_22483619_ChIP-Seq_HELA_Human1.59252033
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.53822138
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.53112106
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48516334
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48120094
50* E2F1_21310950_ChIP-Seq_MCF-7_Human1.46503574
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44137845
52XRN2_22483619_ChIP-Seq_HELA_Human1.43825564
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40425718
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39753665
55SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.39638508
56DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.36206668
57IGF1R_20145208_ChIP-Seq_DFB_Human1.29886860
58MYC_18940864_ChIP-ChIP_HL60_Human1.28858523
59SOX17_20123909_ChIP-Seq_XEN_Mouse1.28174519
60CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.26356774
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.25990099
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.24419252
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.23246400
64EWS_26573619_Chip-Seq_HEK293_Human1.15954071
65TAF15_26573619_Chip-Seq_HEK293_Human1.13513217
66ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13323188
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.13076190
68KDM5A_27292631_Chip-Seq_BREAST_Human1.11270405
69FUS_26573619_Chip-Seq_HEK293_Human1.11075275
70TFEB_21752829_ChIP-Seq_HELA_Human1.09972301
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07578846
72* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05182148
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03470954
74NANOG_16153702_ChIP-ChIP_HESCs_Human1.03187357
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02706289
76WT1_19549856_ChIP-ChIP_CCG9911_Human1.01929977
77CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97999028
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97646645
79ELF5_23300383_ChIP-Seq_T47D_Human0.97382992
80* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96798439
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95136190
82YY1_21170310_ChIP-Seq_MESCs_Mouse0.94871317
83HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93507207
84NOTCH1_21737748_ChIP-Seq_TLL_Human0.93198116
85VDR_22108803_ChIP-Seq_LS180_Human0.89924627
86TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87989888
87NANOG_18555785_ChIP-Seq_MESCs_Mouse0.86907705
88IRF1_19129219_ChIP-ChIP_H3396_Human0.84710285
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.83516744
90REST_19997604_ChIP-ChIP_NEURONS_Mouse0.78698909
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.78194709
92ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.78112069
93SALL4_18804426_ChIP-ChIP_XEN_Mouse0.76844904
94SALL4_22934838_ChIP-ChIP_CD34+_Human0.75455070
95CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.74726915
96ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.74519462
97EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.73435462
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.73191223
99SUZ12_27294783_Chip-Seq_NPCs_Mouse0.73095116
100TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.72803733

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.64365318
2MP0004957_abnormal_blastocyst_morpholog3.36138737
3MP0003806_abnormal_nucleotide_metabolis3.31442336
4MP0010094_abnormal_chromosome_stability3.19180403
5MP0003693_abnormal_embryo_hatching3.16698309
6MP0003941_abnormal_skin_development3.16540506
7MP0002139_abnormal_hepatobiliary_system3.01902243
8MP0006054_spinal_hemorrhage2.67382736
9MP0009697_abnormal_copulation2.60889340
10MP0003111_abnormal_nucleus_morphology2.51040897
11MP0005408_hypopigmentation2.50345454
12MP0003077_abnormal_cell_cycle2.38823530
13MP0003950_abnormal_plasma_membrane2.34514590
14MP0008932_abnormal_embryonic_tissue2.20036108
15MP0003890_abnormal_embryonic-extraembry2.05779564
16MP0008007_abnormal_cellular_replicative2.05333458
17MP0003718_maternal_effect2.02928910
18MP0008877_abnormal_DNA_methylation1.93901320
19MP0002254_reproductive_system_inflammat1.91688057
20MP0003122_maternal_imprinting1.88330806
21MP0003195_calcinosis1.85240214
22MP0002102_abnormal_ear_morphology1.79953719
23MP0001529_abnormal_vocalization1.79297923
24MP0003786_premature_aging1.77053649
25MP0003186_abnormal_redox_activity1.74868172
26MP0001666_abnormal_nutrient_absorption1.73888164
27MP0008057_abnormal_DNA_replication1.73395980
28MP0002938_white_spotting1.63677628
29MP0003221_abnormal_cardiomyocyte_apopto1.62940118
30MP0001730_embryonic_growth_arrest1.57407280
31MP0001697_abnormal_embryo_size1.52880325
32MP0005084_abnormal_gallbladder_morpholo1.51873524
33MP0003121_genomic_imprinting1.51661998
34MP0005365_abnormal_bile_salt1.51460520
35MP0000358_abnormal_cell_content/1.48577983
36MP0006035_abnormal_mitochondrial_morpho1.44756299
37MP0003868_abnormal_feces_composition1.43292991
38MP0003123_paternal_imprinting1.38522669
39MP0006036_abnormal_mitochondrial_physio1.30938573
40MP0001929_abnormal_gametogenesis1.30796064
41MP0004264_abnormal_extraembryonic_tissu1.28427521
42MP0001915_intracranial_hemorrhage1.26246386
43MP0002084_abnormal_developmental_patter1.25041920
44MP0001661_extended_life_span1.24606823
45MP0009780_abnormal_chondrocyte_physiolo1.24474565
46MP0002210_abnormal_sex_determination1.21380475
47MP0005379_endocrine/exocrine_gland_phen1.21320405
48MP0001672_abnormal_embryogenesis/_devel1.20076727
49MP0005380_embryogenesis_phenotype1.20076727
50MP0003937_abnormal_limbs/digits/tail_de1.19147643
51MP0002090_abnormal_vision1.16967922
52MP0002160_abnormal_reproductive_system1.14467216
53MP0000647_abnormal_sebaceous_gland1.13958546
54MP0003567_abnormal_fetal_cardiomyocyte1.12423287
55MP0001293_anophthalmia1.11593882
56MP0002080_prenatal_lethality1.10388713
57MP0001727_abnormal_embryo_implantation1.09669705
58MP0000372_irregular_coat_pigmentation1.08978339
59MP0004197_abnormal_fetal_growth/weight/1.08634903
60MP0001881_abnormal_mammary_gland1.07360726
61MP0010307_abnormal_tumor_latency1.06268531
62MP0004272_abnormal_basement_membrane1.06247336
63MP0003984_embryonic_growth_retardation1.05312847
64MP0010352_gastrointestinal_tract_polyps1.04834146
65MP0002088_abnormal_embryonic_growth/wei1.04738374
66MP0000653_abnormal_sex_gland1.04026151
67MP0002085_abnormal_embryonic_tissue1.02799479
68MP0010234_abnormal_vibrissa_follicle1.00732826
69MP0001145_abnormal_male_reproductive1.00093096
70MP0005410_abnormal_fertilization0.98546932
71MP0003315_abnormal_perineum_morphology0.98237904
72MP0002282_abnormal_trachea_morphology0.96929610
73MP0000350_abnormal_cell_proliferation0.96419217
74MP0008875_abnormal_xenobiotic_pharmacok0.93178463
75MP0010329_abnormal_lipoprotein_level0.91722396
76MP0006072_abnormal_retinal_apoptosis0.90844546
77MP0000569_abnormal_digit_pigmentation0.89665715
78MP0002086_abnormal_extraembryonic_tissu0.88743116
79MP0005636_abnormal_mineral_homeostasis0.88102199
80MP0000627_abnormal_mammary_gland0.87364850
81MP0002751_abnormal_autonomic_nervous0.87276725
82MP0005395_other_phenotype0.86987708
83MP0002233_abnormal_nose_morphology0.86532086
84MP0002295_abnormal_pulmonary_circulatio0.85789552
85MP0009672_abnormal_birth_weight0.84822887
86MP0009703_decreased_birth_body0.83998729
87MP0005248_abnormal_Harderian_gland0.83485951
88MP0002697_abnormal_eye_size0.82700570
89MP0005085_abnormal_gallbladder_physiolo0.82215584
90MP0001286_abnormal_eye_development0.81447343
91MP0001764_abnormal_homeostasis0.80931938
92MP0003698_abnormal_male_reproductive0.79429903
93MP0000516_abnormal_urinary_system0.79285510
94MP0005367_renal/urinary_system_phenotyp0.79285510
95MP0003755_abnormal_palate_morphology0.78214763
96MP0000313_abnormal_cell_death0.77853577
97MP0001119_abnormal_female_reproductive0.77744266
98MP0005332_abnormal_amino_acid0.76681308
99MP0005384_cellular_phenotype0.75500304
100MP0004233_abnormal_muscle_weight0.74514166

Predicted human phenotypes

RankGene SetZ-score
1Increased serum pyruvate (HP:0003542)3.99096160
2Abnormality of glycolysis (HP:0004366)3.92490002
3Type I transferrin isoform profile (HP:0003642)3.23765508
4Abnormality of methionine metabolism (HP:0010901)3.17529165
5Acute necrotizing encephalopathy (HP:0006965)3.15171023
6Prolonged partial thromboplastin time (HP:0003645)3.10582332
7Acute encephalopathy (HP:0006846)3.07341671
8Increased CSF lactate (HP:0002490)3.05103704
9Hepatocellular necrosis (HP:0001404)3.02159457
10Abnormal protein glycosylation (HP:0012346)2.97351160
11Abnormal glycosylation (HP:0012345)2.97351160
12Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.97351160
13Abnormal protein N-linked glycosylation (HP:0012347)2.97351160
14Hepatic necrosis (HP:0002605)2.95922542
15Abnormal mitochondria in muscle tissue (HP:0008316)2.90102064
16Methylmalonic acidemia (HP:0002912)2.81983662
17Hypobetalipoproteinemia (HP:0003563)2.81150443
18Decreased activity of mitochondrial respiratory chain (HP:0008972)2.73420204
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.73420204
20Mitochondrial inheritance (HP:0001427)2.71354494
21Hypoglycemic coma (HP:0001325)2.60988839
22Hypothermia (HP:0002045)2.58604784
23Progressive macrocephaly (HP:0004481)2.58544904
24Reduced antithrombin III activity (HP:0001976)2.52231678
25Cerebral edema (HP:0002181)2.51747823
26Chromosomal breakage induced by crosslinking agents (HP:0003221)2.49317382
27Increased hepatocellular lipid droplets (HP:0006565)2.47096364
28Volvulus (HP:0002580)2.46708105
29Proximal tubulopathy (HP:0000114)2.44819991
30Chromsome breakage (HP:0040012)2.43494806
31Renal cortical cysts (HP:0000803)2.42952793
32Abnormality of aspartate family amino acid metabolism (HP:0010899)2.42238373
33Meckel diverticulum (HP:0002245)2.40599190
34Abnormal lung lobation (HP:0002101)2.39445159
35Lipid accumulation in hepatocytes (HP:0006561)2.37743982
36Abnormality of aromatic amino acid family metabolism (HP:0004338)2.37624354
37Hypoplastic pelvis (HP:0008839)2.37394782
38Pancreatic islet-cell hyperplasia (HP:0004510)2.36945700
39Increased serum lactate (HP:0002151)2.36567395
40Abnormality of the anterior horn cell (HP:0006802)2.35157236
41Degeneration of anterior horn cells (HP:0002398)2.35157236
42Bifid tongue (HP:0010297)2.34901781
43Tetraparesis (HP:0002273)2.34589720
44Papillary thyroid carcinoma (HP:0002895)2.33820081
45Multiple enchondromatosis (HP:0005701)2.28010845
46Abnormality of the ileum (HP:0001549)2.26036813
47Methylmalonic aciduria (HP:0012120)2.20312914
48Short tibia (HP:0005736)2.20217782
49Lactic acidosis (HP:0003128)2.19960658
50Postnatal microcephaly (HP:0005484)2.15813562
51Generalized aminoaciduria (HP:0002909)2.15323667
52Nephroblastoma (Wilms tumor) (HP:0002667)2.15026389
53Megaloblastic anemia (HP:0001889)2.09917182
54Microvesicular hepatic steatosis (HP:0001414)2.08065835
55Aplasia/Hypoplasia of the uvula (HP:0010293)2.05925065
56Secondary amenorrhea (HP:0000869)2.03996228
57Embryonal renal neoplasm (HP:0011794)2.03496966
58Orthostatic hypotension (HP:0001278)2.02593362
59Abnormality of chromosome stability (HP:0003220)2.00712783
60Respiratory failure (HP:0002878)1.98608423
61Intrahepatic cholestasis (HP:0001406)1.97067395
62Lethargy (HP:0001254)1.96052399
63Hypoplasia of the capital femoral epiphysis (HP:0003090)1.95256723
64Medial flaring of the eyebrow (HP:0010747)1.95235524
65Thyroid carcinoma (HP:0002890)1.94841012
66Abnormality of the preputium (HP:0100587)1.94547119
67Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93115695
68Abnormality of alanine metabolism (HP:0010916)1.93115695
69Hyperalaninemia (HP:0003348)1.93115695
70Hypoglycemic seizures (HP:0002173)1.92934317
71Small epiphyses (HP:0010585)1.91563478
72CNS demyelination (HP:0007305)1.91173558
73Congenital primary aphakia (HP:0007707)1.88907637
74Gout (HP:0001997)1.87273531
75Hypokinesia (HP:0002375)1.86857204
76Neoplasm of the adrenal gland (HP:0100631)1.86493288
77Abnormal tarsal ossification (HP:0008369)1.86483704
78Hypolipoproteinemia (HP:0010981)1.84816677
79Nephrogenic diabetes insipidus (HP:0009806)1.82634892
80Abnormal gallbladder physiology (HP:0012438)1.82467561
81Cholecystitis (HP:0001082)1.82467561
82Increased nuchal translucency (HP:0010880)1.81591423
83Deep venous thrombosis (HP:0002625)1.80606937
84Overlapping toe (HP:0001845)1.79216874
85Leukodystrophy (HP:0002415)1.78210420
86Aplasia/Hypoplasia of the tibia (HP:0005772)1.77820964
87Gonadotropin excess (HP:0000837)1.77358908
88Cortical dysplasia (HP:0002539)1.76169406
89Abnormality of serum amino acid levels (HP:0003112)1.75453915
90Abnormality of the pons (HP:0007361)1.75434144
91Hyperinsulinemic hypoglycemia (HP:0000825)1.75419095
92Abnormality of the pancreatic islet cells (HP:0006476)1.74483917
93Abnormality of endocrine pancreas physiology (HP:0012093)1.74483917
94Abnormality of vitamin B metabolism (HP:0004340)1.70994491
95Entropion (HP:0000621)1.70484290
96Hyperglycinemia (HP:0002154)1.69602061
97Small intestinal stenosis (HP:0012848)1.69118481
98Duodenal stenosis (HP:0100867)1.69118481
99Exercise intolerance (HP:0003546)1.69102989
100Spontaneous abortion (HP:0005268)1.69101001

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK34.43032907
2EIF2AK14.42613817
3TSSK63.09568067
4MST43.08861715
5SRPK13.06484646
6NEK13.02652521
7PBK2.88415099
8PNCK2.87454311
9TTK2.30315964
10BUB12.28083063
11PLK32.13720041
12TRIM282.05763194
13NUAK12.04708226
14BRSK21.98603000
15BCR1.97967607
16WEE11.91043938
17PDK21.88326324
18PLK41.88092622
19MAP3K121.87369253
20STK161.84801238
21VRK21.79277138
22STK38L1.78875068
23LATS11.62585369
24PLK21.60614753
25ERBB31.53841536
26CDC71.46947845
27ZAK1.40736469
28MKNK11.33217906
29MKNK21.29596373
30TAF11.29328877
31STK241.26960173
32VRK11.26134753
33SCYL21.20546763
34PLK11.13289137
35NEK91.12788605
36WNK31.09146378
37STK31.06390262
38MAP4K21.05239531
39ERBB41.04354768
40CCNB11.03843478
41NME10.96777549
42BRSK10.94091117
43LIMK10.93962054
44RPS6KA40.91179990
45MAP3K40.90895330
46EIF2AK20.88363211
47BRD40.85395627
48MAPKAPK50.83340510
49ATR0.81792184
50CSNK1G10.81769784
51ATM0.74856812
52FGFR10.74542950
53TNIK0.74094917
54STK390.73962928
55BCKDK0.70058822
56AURKB0.68532443
57ACVR1B0.67050290
58BMPR1B0.66123521
59PASK0.65649417
60CDK70.64441307
61CHEK10.63848646
62YES10.61770996
63PAK40.61401111
64CSNK2A20.60846777
65CSNK1G30.60507869
66CSNK2A10.60362277
67WNK40.58594696
68DYRK30.58294852
69CSNK1E0.54909811
70MAPKAPK30.53801021
71CLK10.51871937
72CSNK1A1L0.51852023
73CSNK1G20.50867511
74TESK10.49285904
75AKT30.48072894
76CHEK20.46324805
77FER0.45338491
78FGFR40.44930314
79PRKCE0.44608320
80NEK60.44462206
81FLT30.43716841
82MAP3K50.42692279
83AKT20.38826180
84CDK90.38005124
85MAP3K90.37074386
86NEK20.35049100
87CDK60.34197618
88LATS20.34062218
89PIM20.33245986
90AURKA0.32411710
91FGFR30.32121421
92RPS6KB10.30164048
93CDK10.28880927
94PRKDC0.26885064
95PRKCI0.26641965
96MST1R0.26444019
97STK40.25651145
98DAPK10.24400970
99ALK0.22782570
100CDK80.22762949

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.34243220
2* Protein export_Homo sapiens_hsa030603.74102241
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.66301161
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.54368762
5Steroid biosynthesis_Homo sapiens_hsa001002.52211507
6Mismatch repair_Homo sapiens_hsa034302.51156686
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.49248623
8Non-homologous end-joining_Homo sapiens_hsa034502.44391839
9Propanoate metabolism_Homo sapiens_hsa006402.15705731
10Sulfur metabolism_Homo sapiens_hsa009202.09832889
11RNA transport_Homo sapiens_hsa030132.08231317
12Nucleotide excision repair_Homo sapiens_hsa034202.05356588
13Spliceosome_Homo sapiens_hsa030402.01760831
14Fatty acid elongation_Homo sapiens_hsa000621.99893473
15DNA replication_Homo sapiens_hsa030301.98232435
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.95017379
17Basal transcription factors_Homo sapiens_hsa030221.86036489
18RNA polymerase_Homo sapiens_hsa030201.80284187
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.76949665
20One carbon pool by folate_Homo sapiens_hsa006701.76238800
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69465897
22Oxidative phosphorylation_Homo sapiens_hsa001901.69178091
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.66363946
24Selenocompound metabolism_Homo sapiens_hsa004501.65121006
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.64972051
26Homologous recombination_Homo sapiens_hsa034401.62401317
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59270469
28RNA degradation_Homo sapiens_hsa030181.58733528
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57134312
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.43850446
31Base excision repair_Homo sapiens_hsa034101.43158512
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43116365
33Parkinsons disease_Homo sapiens_hsa050121.39398415
34Pyruvate metabolism_Homo sapiens_hsa006201.36073188
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.35226934
36Carbon metabolism_Homo sapiens_hsa012001.33653044
37N-Glycan biosynthesis_Homo sapiens_hsa005101.28725950
38Fatty acid metabolism_Homo sapiens_hsa012121.21866338
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.19007944
40Fanconi anemia pathway_Homo sapiens_hsa034601.18936104
41Cell cycle_Homo sapiens_hsa041101.18855206
42mRNA surveillance pathway_Homo sapiens_hsa030151.18400373
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.16666844
44Pyrimidine metabolism_Homo sapiens_hsa002401.14359241
45Biosynthesis of amino acids_Homo sapiens_hsa012301.13630379
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13580709
47Huntingtons disease_Homo sapiens_hsa050161.11213594
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08198497
49Folate biosynthesis_Homo sapiens_hsa007901.08132693
50Butanoate metabolism_Homo sapiens_hsa006501.05317891
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92590622
52Fatty acid degradation_Homo sapiens_hsa000710.90197293
53Vibrio cholerae infection_Homo sapiens_hsa051100.89369228
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89289677
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88579986
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.88024430
57Regulation of autophagy_Homo sapiens_hsa041400.87283832
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.85579240
59Glutathione metabolism_Homo sapiens_hsa004800.84837627
60Peroxisome_Homo sapiens_hsa041460.83184802
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.79684312
62p53 signaling pathway_Homo sapiens_hsa041150.78586214
63Purine metabolism_Homo sapiens_hsa002300.78124690
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76924590
65Alzheimers disease_Homo sapiens_hsa050100.72297948
66Vitamin B6 metabolism_Homo sapiens_hsa007500.70008117
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69349447
68Vitamin digestion and absorption_Homo sapiens_hsa049770.69151547
69Legionellosis_Homo sapiens_hsa051340.68508328
70Metabolic pathways_Homo sapiens_hsa011000.68260151
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66689316
72Pentose phosphate pathway_Homo sapiens_hsa000300.61666054
73Complement and coagulation cascades_Homo sapiens_hsa046100.61555555
74Oocyte meiosis_Homo sapiens_hsa041140.61165150
75Fat digestion and absorption_Homo sapiens_hsa049750.55233999
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53665297
77Collecting duct acid secretion_Homo sapiens_hsa049660.52465004
78Fructose and mannose metabolism_Homo sapiens_hsa000510.49408566
79beta-Alanine metabolism_Homo sapiens_hsa004100.47084770
80Arginine and proline metabolism_Homo sapiens_hsa003300.46384426
81TGF-beta signaling pathway_Homo sapiens_hsa043500.46185452
82Arginine biosynthesis_Homo sapiens_hsa002200.43884941
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.43695047
84Sphingolipid metabolism_Homo sapiens_hsa006000.40221892
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38792526
86Ribosome_Homo sapiens_hsa030100.38456629
87Caffeine metabolism_Homo sapiens_hsa002320.30638776
88Retinol metabolism_Homo sapiens_hsa008300.30605736
89Starch and sucrose metabolism_Homo sapiens_hsa005000.28345479
90Chemical carcinogenesis_Homo sapiens_hsa052040.27301223
91Epstein-Barr virus infection_Homo sapiens_hsa051690.26681723
92Tryptophan metabolism_Homo sapiens_hsa003800.26471867
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.25066702
94Circadian rhythm_Homo sapiens_hsa047100.24981356
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23788913
96Galactose metabolism_Homo sapiens_hsa000520.22223085
97Tyrosine metabolism_Homo sapiens_hsa003500.21326427
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.20836062
99Fatty acid biosynthesis_Homo sapiens_hsa000610.19869391
100Phenylalanine metabolism_Homo sapiens_hsa003600.19840093

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »