Rank | Gene Set | Z-score |
---|---|---|
1 | proteasome assembly (GO:0043248) | 4.85563049 |
2 | COPII vesicle coating (GO:0048208) | 4.67123421 |
3 | COPI coating of Golgi vesicle (GO:0048205) | 4.46704625 |
4 | Golgi transport vesicle coating (GO:0048200) | 4.46704625 |
5 | ribosome assembly (GO:0042255) | 4.37852087 |
6 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.00758931 |
7 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.90542928 |
8 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.90440770 |
9 | establishment of integrated proviral latency (GO:0075713) | 3.87543778 |
10 | establishment of viral latency (GO:0019043) | 3.85735100 |
11 | ER overload response (GO:0006983) | 3.76642007 |
12 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.73195974 |
13 | DNA damage response, detection of DNA damage (GO:0042769) | 3.67449943 |
14 | negative regulation of ligase activity (GO:0051352) | 3.66195730 |
15 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.66195730 |
16 | tRNA aminoacylation for protein translation (GO:0006418) | 3.63551712 |
17 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.63205490 |
18 | regulation of centriole replication (GO:0046599) | 3.58426850 |
19 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.56009051 |
20 | amino acid activation (GO:0043038) | 3.52860256 |
21 | tRNA aminoacylation (GO:0043039) | 3.52860256 |
22 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.52334439 |
23 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.52334439 |
24 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.52334439 |
25 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.52048914 |
26 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.52048914 |
27 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.40087488 |
28 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.40087488 |
29 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.35388909 |
30 | cullin deneddylation (GO:0010388) | 3.35161798 |
31 | mitotic metaphase plate congression (GO:0007080) | 3.30613118 |
32 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.28468623 |
33 | cholesterol biosynthetic process (GO:0006695) | 3.25546703 |
34 | CENP-A containing nucleosome assembly (GO:0034080) | 3.24413911 |
35 | rRNA modification (GO:0000154) | 3.22159294 |
36 | rRNA methylation (GO:0031167) | 3.19579990 |
37 | 7-methylguanosine mRNA capping (GO:0006370) | 3.18987839 |
38 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.17044855 |
39 | non-recombinational repair (GO:0000726) | 3.17044855 |
40 | nuclear pore complex assembly (GO:0051292) | 3.12943709 |
41 | positive regulation of ligase activity (GO:0051351) | 3.12595394 |
42 | metaphase plate congression (GO:0051310) | 3.12590205 |
43 | nucleotide-sugar biosynthetic process (GO:0009226) | 3.10811085 |
44 | chromatin remodeling at centromere (GO:0031055) | 3.10567727 |
45 | RNA capping (GO:0036260) | 3.08439848 |
46 | 7-methylguanosine RNA capping (GO:0009452) | 3.08439848 |
47 | DNA ligation (GO:0006266) | 3.08237080 |
48 | sterol biosynthetic process (GO:0016126) | 3.03522986 |
49 | synapsis (GO:0007129) | 3.01684695 |
50 | protein deneddylation (GO:0000338) | 3.01051358 |
51 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 2.98015915 |
52 | regulation of meiosis I (GO:0060631) | 2.95315013 |
53 | histone exchange (GO:0043486) | 2.94391747 |
54 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.93499650 |
55 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 2.92348465 |
56 | maturation of 5.8S rRNA (GO:0000460) | 2.91856936 |
57 | tricarboxylic acid cycle (GO:0006099) | 2.91226335 |
58 | ER to Golgi vesicle-mediated transport (GO:0006888) | 2.89004181 |
59 | resolution of meiotic recombination intermediates (GO:0000712) | 2.86590870 |
60 | dolichol-linked oligosaccharide biosynthetic process (GO:0006488) | 2.82987923 |
61 | formation of translation preinitiation complex (GO:0001731) | 2.82681889 |
62 | respiratory chain complex IV assembly (GO:0008535) | 2.82585152 |
63 | regulation of ligase activity (GO:0051340) | 2.81634052 |
64 | ribosome biogenesis (GO:0042254) | 2.79964914 |
65 | ribonucleoprotein complex disassembly (GO:0032988) | 2.78376129 |
66 | mitotic sister chromatid cohesion (GO:0007064) | 2.74913153 |
67 | negative regulation of protein ubiquitination (GO:0031397) | 2.72725793 |
68 | nuclear pore organization (GO:0006999) | 2.69851965 |
69 | folic acid-containing compound biosynthetic process (GO:0009396) | 2.69840607 |
70 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.68913869 |
71 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.68913869 |
72 | spliceosomal snRNP assembly (GO:0000387) | 2.67927542 |
73 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO | 2.67699149 |
74 | cell cycle G1/S phase transition (GO:0044843) | 2.67357961 |
75 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.67357961 |
76 | purine nucleobase biosynthetic process (GO:0009113) | 2.66460108 |
77 | protein localization to kinetochore (GO:0034501) | 2.66042495 |
78 | histone mRNA metabolic process (GO:0008334) | 2.65673973 |
79 | establishment of chromosome localization (GO:0051303) | 2.65145406 |
80 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.64996837 |
81 | organelle disassembly (GO:1903008) | 2.64070331 |
82 | pteridine-containing compound biosynthetic process (GO:0042559) | 2.63738004 |
83 | regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235 | 2.62725018 |
84 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.62663092 |
85 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.60435364 |
86 | DNA replication-independent nucleosome organization (GO:0034724) | 2.60435364 |
87 | regulation of DNA endoreduplication (GO:0032875) | 2.60401142 |
88 | vesicle coating (GO:0006901) | 2.60333682 |
89 | kinetochore organization (GO:0051383) | 2.59692747 |
90 | regulation of cellular amine metabolic process (GO:0033238) | 2.58392039 |
91 | mitotic spindle checkpoint (GO:0071174) | 2.58268787 |
92 | positive regulation of cell cycle arrest (GO:0071158) | 2.58025236 |
93 | regulation of translation in response to stress (GO:0043555) | 2.58008010 |
94 | DNA double-strand break processing (GO:0000729) | 2.57520468 |
95 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 2.56366123 |
96 | protein refolding (GO:0042026) | 2.55514847 |
97 | mitotic nuclear envelope disassembly (GO:0007077) | 2.54856700 |
98 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.54570826 |
99 | negative regulation of protein modification by small protein conjugation or removal (GO:1903321) | 2.52840216 |
100 | spindle checkpoint (GO:0031577) | 2.52150567 |
Rank | Gene Set | Z-score |
---|---|---|
1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.78835768 |
2 | * GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.19757166 |
3 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.67017500 |
4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.37398042 |
5 | * CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.32957181 |
6 | ELK1_19687146_ChIP-ChIP_HELA_Human | 3.16930326 |
7 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.89360891 |
8 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.85164116 |
9 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.84090306 |
10 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.75244785 |
11 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.73949923 |
12 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.73725184 |
13 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.55530586 |
14 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.55283810 |
15 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.49550678 |
16 | * PADI4_21655091_ChIP-ChIP_MCF-7_Human | 2.48791589 |
17 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.48237458 |
18 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.39946804 |
19 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.39018952 |
20 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.33200098 |
21 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.31932200 |
22 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 2.23187788 |
23 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.17058668 |
24 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.13716605 |
25 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.12066774 |
26 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 2.07919800 |
27 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.05718686 |
28 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.01519560 |
29 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 2.00197654 |
30 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.98511195 |
31 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.94302691 |
32 | * GABP_19822575_ChIP-Seq_HepG2_Human | 1.93173631 |
33 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.85676558 |
34 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.84633171 |
35 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.80219689 |
36 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.79585564 |
37 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.78124152 |
38 | * PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.75167125 |
39 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.72406738 |
40 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.71285357 |
41 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.69336308 |
42 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.69039282 |
43 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.60844714 |
44 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.60508525 |
45 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.59252033 |
46 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.53822138 |
47 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.53112106 |
48 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.48516334 |
49 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.48120094 |
50 | * E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.46503574 |
51 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.44137845 |
52 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.43825564 |
53 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.40425718 |
54 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.39753665 |
55 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.39638508 |
56 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.36206668 |
57 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.29886860 |
58 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.28858523 |
59 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.28174519 |
60 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.26356774 |
61 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.25990099 |
62 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.24419252 |
63 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.23246400 |
64 | EWS_26573619_Chip-Seq_HEK293_Human | 1.15954071 |
65 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.13513217 |
66 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.13323188 |
67 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.13076190 |
68 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.11270405 |
69 | FUS_26573619_Chip-Seq_HEK293_Human | 1.11075275 |
70 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.09972301 |
71 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.07578846 |
72 | * RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.05182148 |
73 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.03470954 |
74 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.03187357 |
75 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.02706289 |
76 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.01929977 |
77 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.97999028 |
78 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.97646645 |
79 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.97382992 |
80 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.96798439 |
81 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.95136190 |
82 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 0.94871317 |
83 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 0.93507207 |
84 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.93198116 |
85 | VDR_22108803_ChIP-Seq_LS180_Human | 0.89924627 |
86 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.87989888 |
87 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.86907705 |
88 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.84710285 |
89 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.83516744 |
90 | REST_19997604_ChIP-ChIP_NEURONS_Mouse | 0.78698909 |
91 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.78194709 |
92 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 0.78112069 |
93 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.76844904 |
94 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.75455070 |
95 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.74726915 |
96 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.74519462 |
97 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 0.73435462 |
98 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.73191223 |
99 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.73095116 |
100 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 0.72803733 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0008058_abnormal_DNA_repair | 3.64365318 |
2 | MP0004957_abnormal_blastocyst_morpholog | 3.36138737 |
3 | MP0003806_abnormal_nucleotide_metabolis | 3.31442336 |
4 | MP0010094_abnormal_chromosome_stability | 3.19180403 |
5 | MP0003693_abnormal_embryo_hatching | 3.16698309 |
6 | MP0003941_abnormal_skin_development | 3.16540506 |
7 | MP0002139_abnormal_hepatobiliary_system | 3.01902243 |
8 | MP0006054_spinal_hemorrhage | 2.67382736 |
9 | MP0009697_abnormal_copulation | 2.60889340 |
10 | MP0003111_abnormal_nucleus_morphology | 2.51040897 |
11 | MP0005408_hypopigmentation | 2.50345454 |
12 | MP0003077_abnormal_cell_cycle | 2.38823530 |
13 | MP0003950_abnormal_plasma_membrane | 2.34514590 |
14 | MP0008932_abnormal_embryonic_tissue | 2.20036108 |
15 | MP0003890_abnormal_embryonic-extraembry | 2.05779564 |
16 | MP0008007_abnormal_cellular_replicative | 2.05333458 |
17 | MP0003718_maternal_effect | 2.02928910 |
18 | MP0008877_abnormal_DNA_methylation | 1.93901320 |
19 | MP0002254_reproductive_system_inflammat | 1.91688057 |
20 | MP0003122_maternal_imprinting | 1.88330806 |
21 | MP0003195_calcinosis | 1.85240214 |
22 | MP0002102_abnormal_ear_morphology | 1.79953719 |
23 | MP0001529_abnormal_vocalization | 1.79297923 |
24 | MP0003786_premature_aging | 1.77053649 |
25 | MP0003186_abnormal_redox_activity | 1.74868172 |
26 | MP0001666_abnormal_nutrient_absorption | 1.73888164 |
27 | MP0008057_abnormal_DNA_replication | 1.73395980 |
28 | MP0002938_white_spotting | 1.63677628 |
29 | MP0003221_abnormal_cardiomyocyte_apopto | 1.62940118 |
30 | MP0001730_embryonic_growth_arrest | 1.57407280 |
31 | MP0001697_abnormal_embryo_size | 1.52880325 |
32 | MP0005084_abnormal_gallbladder_morpholo | 1.51873524 |
33 | MP0003121_genomic_imprinting | 1.51661998 |
34 | MP0005365_abnormal_bile_salt | 1.51460520 |
35 | MP0000358_abnormal_cell_content/ | 1.48577983 |
36 | MP0006035_abnormal_mitochondrial_morpho | 1.44756299 |
37 | MP0003868_abnormal_feces_composition | 1.43292991 |
38 | MP0003123_paternal_imprinting | 1.38522669 |
39 | MP0006036_abnormal_mitochondrial_physio | 1.30938573 |
40 | MP0001929_abnormal_gametogenesis | 1.30796064 |
41 | MP0004264_abnormal_extraembryonic_tissu | 1.28427521 |
42 | MP0001915_intracranial_hemorrhage | 1.26246386 |
43 | MP0002084_abnormal_developmental_patter | 1.25041920 |
44 | MP0001661_extended_life_span | 1.24606823 |
45 | MP0009780_abnormal_chondrocyte_physiolo | 1.24474565 |
46 | MP0002210_abnormal_sex_determination | 1.21380475 |
47 | MP0005379_endocrine/exocrine_gland_phen | 1.21320405 |
48 | MP0001672_abnormal_embryogenesis/_devel | 1.20076727 |
49 | MP0005380_embryogenesis_phenotype | 1.20076727 |
50 | MP0003937_abnormal_limbs/digits/tail_de | 1.19147643 |
51 | MP0002090_abnormal_vision | 1.16967922 |
52 | MP0002160_abnormal_reproductive_system | 1.14467216 |
53 | MP0000647_abnormal_sebaceous_gland | 1.13958546 |
54 | MP0003567_abnormal_fetal_cardiomyocyte | 1.12423287 |
55 | MP0001293_anophthalmia | 1.11593882 |
56 | MP0002080_prenatal_lethality | 1.10388713 |
57 | MP0001727_abnormal_embryo_implantation | 1.09669705 |
58 | MP0000372_irregular_coat_pigmentation | 1.08978339 |
59 | MP0004197_abnormal_fetal_growth/weight/ | 1.08634903 |
60 | MP0001881_abnormal_mammary_gland | 1.07360726 |
61 | MP0010307_abnormal_tumor_latency | 1.06268531 |
62 | MP0004272_abnormal_basement_membrane | 1.06247336 |
63 | MP0003984_embryonic_growth_retardation | 1.05312847 |
64 | MP0010352_gastrointestinal_tract_polyps | 1.04834146 |
65 | MP0002088_abnormal_embryonic_growth/wei | 1.04738374 |
66 | MP0000653_abnormal_sex_gland | 1.04026151 |
67 | MP0002085_abnormal_embryonic_tissue | 1.02799479 |
68 | MP0010234_abnormal_vibrissa_follicle | 1.00732826 |
69 | MP0001145_abnormal_male_reproductive | 1.00093096 |
70 | MP0005410_abnormal_fertilization | 0.98546932 |
71 | MP0003315_abnormal_perineum_morphology | 0.98237904 |
72 | MP0002282_abnormal_trachea_morphology | 0.96929610 |
73 | MP0000350_abnormal_cell_proliferation | 0.96419217 |
74 | MP0008875_abnormal_xenobiotic_pharmacok | 0.93178463 |
75 | MP0010329_abnormal_lipoprotein_level | 0.91722396 |
76 | MP0006072_abnormal_retinal_apoptosis | 0.90844546 |
77 | MP0000569_abnormal_digit_pigmentation | 0.89665715 |
78 | MP0002086_abnormal_extraembryonic_tissu | 0.88743116 |
79 | MP0005636_abnormal_mineral_homeostasis | 0.88102199 |
80 | MP0000627_abnormal_mammary_gland | 0.87364850 |
81 | MP0002751_abnormal_autonomic_nervous | 0.87276725 |
82 | MP0005395_other_phenotype | 0.86987708 |
83 | MP0002233_abnormal_nose_morphology | 0.86532086 |
84 | MP0002295_abnormal_pulmonary_circulatio | 0.85789552 |
85 | MP0009672_abnormal_birth_weight | 0.84822887 |
86 | MP0009703_decreased_birth_body | 0.83998729 |
87 | MP0005248_abnormal_Harderian_gland | 0.83485951 |
88 | MP0002697_abnormal_eye_size | 0.82700570 |
89 | MP0005085_abnormal_gallbladder_physiolo | 0.82215584 |
90 | MP0001286_abnormal_eye_development | 0.81447343 |
91 | MP0001764_abnormal_homeostasis | 0.80931938 |
92 | MP0003698_abnormal_male_reproductive | 0.79429903 |
93 | MP0000516_abnormal_urinary_system | 0.79285510 |
94 | MP0005367_renal/urinary_system_phenotyp | 0.79285510 |
95 | MP0003755_abnormal_palate_morphology | 0.78214763 |
96 | MP0000313_abnormal_cell_death | 0.77853577 |
97 | MP0001119_abnormal_female_reproductive | 0.77744266 |
98 | MP0005332_abnormal_amino_acid | 0.76681308 |
99 | MP0005384_cellular_phenotype | 0.75500304 |
100 | MP0004233_abnormal_muscle_weight | 0.74514166 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Increased serum pyruvate (HP:0003542) | 3.99096160 |
2 | Abnormality of glycolysis (HP:0004366) | 3.92490002 |
3 | Type I transferrin isoform profile (HP:0003642) | 3.23765508 |
4 | Abnormality of methionine metabolism (HP:0010901) | 3.17529165 |
5 | Acute necrotizing encephalopathy (HP:0006965) | 3.15171023 |
6 | Prolonged partial thromboplastin time (HP:0003645) | 3.10582332 |
7 | Acute encephalopathy (HP:0006846) | 3.07341671 |
8 | Increased CSF lactate (HP:0002490) | 3.05103704 |
9 | Hepatocellular necrosis (HP:0001404) | 3.02159457 |
10 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.97351160 |
11 | Abnormal protein glycosylation (HP:0012346) | 2.97351160 |
12 | Abnormal glycosylation (HP:0012345) | 2.97351160 |
13 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.97351160 |
14 | Hepatic necrosis (HP:0002605) | 2.95922542 |
15 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.90102064 |
16 | Methylmalonic acidemia (HP:0002912) | 2.81983662 |
17 | Hypobetalipoproteinemia (HP:0003563) | 2.81150443 |
18 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.73420204 |
19 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.73420204 |
20 | Mitochondrial inheritance (HP:0001427) | 2.71354494 |
21 | Hypoglycemic coma (HP:0001325) | 2.60988839 |
22 | Hypothermia (HP:0002045) | 2.58604784 |
23 | Progressive macrocephaly (HP:0004481) | 2.58544904 |
24 | Reduced antithrombin III activity (HP:0001976) | 2.52231678 |
25 | Cerebral edema (HP:0002181) | 2.51747823 |
26 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.49317382 |
27 | Increased hepatocellular lipid droplets (HP:0006565) | 2.47096364 |
28 | Volvulus (HP:0002580) | 2.46708105 |
29 | Proximal tubulopathy (HP:0000114) | 2.44819991 |
30 | Chromsome breakage (HP:0040012) | 2.43494806 |
31 | Renal cortical cysts (HP:0000803) | 2.42952793 |
32 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.42238373 |
33 | Meckel diverticulum (HP:0002245) | 2.40599190 |
34 | Abnormal lung lobation (HP:0002101) | 2.39445159 |
35 | Lipid accumulation in hepatocytes (HP:0006561) | 2.37743982 |
36 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 2.37624354 |
37 | Hypoplastic pelvis (HP:0008839) | 2.37394782 |
38 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.36945700 |
39 | Increased serum lactate (HP:0002151) | 2.36567395 |
40 | Degeneration of anterior horn cells (HP:0002398) | 2.35157236 |
41 | Abnormality of the anterior horn cell (HP:0006802) | 2.35157236 |
42 | Bifid tongue (HP:0010297) | 2.34901781 |
43 | Tetraparesis (HP:0002273) | 2.34589720 |
44 | Papillary thyroid carcinoma (HP:0002895) | 2.33820081 |
45 | Multiple enchondromatosis (HP:0005701) | 2.28010845 |
46 | Abnormality of the ileum (HP:0001549) | 2.26036813 |
47 | Methylmalonic aciduria (HP:0012120) | 2.20312914 |
48 | Short tibia (HP:0005736) | 2.20217782 |
49 | Lactic acidosis (HP:0003128) | 2.19960658 |
50 | Postnatal microcephaly (HP:0005484) | 2.15813562 |
51 | Generalized aminoaciduria (HP:0002909) | 2.15323667 |
52 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.15026389 |
53 | Megaloblastic anemia (HP:0001889) | 2.09917182 |
54 | Microvesicular hepatic steatosis (HP:0001414) | 2.08065835 |
55 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.05925065 |
56 | Secondary amenorrhea (HP:0000869) | 2.03996228 |
57 | Embryonal renal neoplasm (HP:0011794) | 2.03496966 |
58 | Orthostatic hypotension (HP:0001278) | 2.02593362 |
59 | Abnormality of chromosome stability (HP:0003220) | 2.00712783 |
60 | Respiratory failure (HP:0002878) | 1.98608423 |
61 | Intrahepatic cholestasis (HP:0001406) | 1.97067395 |
62 | Lethargy (HP:0001254) | 1.96052399 |
63 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.95256723 |
64 | Medial flaring of the eyebrow (HP:0010747) | 1.95235524 |
65 | Thyroid carcinoma (HP:0002890) | 1.94841012 |
66 | Abnormality of the preputium (HP:0100587) | 1.94547119 |
67 | Abnormality of alanine metabolism (HP:0010916) | 1.93115695 |
68 | Hyperalaninemia (HP:0003348) | 1.93115695 |
69 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.93115695 |
70 | Hypoglycemic seizures (HP:0002173) | 1.92934317 |
71 | Small epiphyses (HP:0010585) | 1.91563478 |
72 | CNS demyelination (HP:0007305) | 1.91173558 |
73 | Congenital primary aphakia (HP:0007707) | 1.88907637 |
74 | Gout (HP:0001997) | 1.87273531 |
75 | Hypokinesia (HP:0002375) | 1.86857204 |
76 | Neoplasm of the adrenal gland (HP:0100631) | 1.86493288 |
77 | Abnormal tarsal ossification (HP:0008369) | 1.86483704 |
78 | Hypolipoproteinemia (HP:0010981) | 1.84816677 |
79 | Nephrogenic diabetes insipidus (HP:0009806) | 1.82634892 |
80 | Abnormal gallbladder physiology (HP:0012438) | 1.82467561 |
81 | Cholecystitis (HP:0001082) | 1.82467561 |
82 | Increased nuchal translucency (HP:0010880) | 1.81591423 |
83 | Deep venous thrombosis (HP:0002625) | 1.80606937 |
84 | Overlapping toe (HP:0001845) | 1.79216874 |
85 | Leukodystrophy (HP:0002415) | 1.78210420 |
86 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.77820964 |
87 | Gonadotropin excess (HP:0000837) | 1.77358908 |
88 | Cortical dysplasia (HP:0002539) | 1.76169406 |
89 | Abnormality of serum amino acid levels (HP:0003112) | 1.75453915 |
90 | Abnormality of the pons (HP:0007361) | 1.75434144 |
91 | Hyperinsulinemic hypoglycemia (HP:0000825) | 1.75419095 |
92 | Abnormality of endocrine pancreas physiology (HP:0012093) | 1.74483917 |
93 | Abnormality of the pancreatic islet cells (HP:0006476) | 1.74483917 |
94 | Abnormality of vitamin B metabolism (HP:0004340) | 1.70994491 |
95 | Entropion (HP:0000621) | 1.70484290 |
96 | Hyperglycinemia (HP:0002154) | 1.69602061 |
97 | Small intestinal stenosis (HP:0012848) | 1.69118481 |
98 | Duodenal stenosis (HP:0100867) | 1.69118481 |
99 | Exercise intolerance (HP:0003546) | 1.69102989 |
100 | Spontaneous abortion (HP:0005268) | 1.69101001 |
Rank | Gene Set | Z-score |
---|---|---|
1 | EIF2AK3 | 4.43032907 |
2 | EIF2AK1 | 4.42613817 |
3 | TSSK6 | 3.09568067 |
4 | MST4 | 3.08861715 |
5 | SRPK1 | 3.06484646 |
6 | NEK1 | 3.02652521 |
7 | PBK | 2.88415099 |
8 | PNCK | 2.87454311 |
9 | TTK | 2.30315964 |
10 | BUB1 | 2.28083063 |
11 | PLK3 | 2.13720041 |
12 | TRIM28 | 2.05763194 |
13 | NUAK1 | 2.04708226 |
14 | BRSK2 | 1.98603000 |
15 | BCR | 1.97967607 |
16 | WEE1 | 1.91043938 |
17 | PDK2 | 1.88326324 |
18 | PLK4 | 1.88092622 |
19 | MAP3K12 | 1.87369253 |
20 | STK16 | 1.84801238 |
21 | VRK2 | 1.79277138 |
22 | STK38L | 1.78875068 |
23 | LATS1 | 1.62585369 |
24 | PLK2 | 1.60614753 |
25 | ERBB3 | 1.53841536 |
26 | CDC7 | 1.46947845 |
27 | ZAK | 1.40736469 |
28 | MKNK1 | 1.33217906 |
29 | MKNK2 | 1.29596373 |
30 | TAF1 | 1.29328877 |
31 | STK24 | 1.26960173 |
32 | VRK1 | 1.26134753 |
33 | SCYL2 | 1.20546763 |
34 | PLK1 | 1.13289137 |
35 | NEK9 | 1.12788605 |
36 | WNK3 | 1.09146378 |
37 | STK3 | 1.06390262 |
38 | MAP4K2 | 1.05239531 |
39 | ERBB4 | 1.04354768 |
40 | CCNB1 | 1.03843478 |
41 | NME1 | 0.96777549 |
42 | BRSK1 | 0.94091117 |
43 | LIMK1 | 0.93962054 |
44 | RPS6KA4 | 0.91179990 |
45 | MAP3K4 | 0.90895330 |
46 | EIF2AK2 | 0.88363211 |
47 | BRD4 | 0.85395627 |
48 | MAPKAPK5 | 0.83340510 |
49 | ATR | 0.81792184 |
50 | CSNK1G1 | 0.81769784 |
51 | ATM | 0.74856812 |
52 | FGFR1 | 0.74542950 |
53 | TNIK | 0.74094917 |
54 | STK39 | 0.73962928 |
55 | BCKDK | 0.70058822 |
56 | AURKB | 0.68532443 |
57 | ACVR1B | 0.67050290 |
58 | BMPR1B | 0.66123521 |
59 | PASK | 0.65649417 |
60 | CDK7 | 0.64441307 |
61 | CHEK1 | 0.63848646 |
62 | YES1 | 0.61770996 |
63 | PAK4 | 0.61401111 |
64 | CSNK2A2 | 0.60846777 |
65 | CSNK1G3 | 0.60507869 |
66 | CSNK2A1 | 0.60362277 |
67 | WNK4 | 0.58594696 |
68 | DYRK3 | 0.58294852 |
69 | CSNK1E | 0.54909811 |
70 | MAPKAPK3 | 0.53801021 |
71 | CLK1 | 0.51871937 |
72 | CSNK1A1L | 0.51852023 |
73 | CSNK1G2 | 0.50867511 |
74 | TESK1 | 0.49285904 |
75 | AKT3 | 0.48072894 |
76 | CHEK2 | 0.46324805 |
77 | FER | 0.45338491 |
78 | FGFR4 | 0.44930314 |
79 | PRKCE | 0.44608320 |
80 | NEK6 | 0.44462206 |
81 | FLT3 | 0.43716841 |
82 | MAP3K5 | 0.42692279 |
83 | AKT2 | 0.38826180 |
84 | CDK9 | 0.38005124 |
85 | MAP3K9 | 0.37074386 |
86 | NEK2 | 0.35049100 |
87 | CDK6 | 0.34197618 |
88 | LATS2 | 0.34062218 |
89 | PIM2 | 0.33245986 |
90 | AURKA | 0.32411710 |
91 | FGFR3 | 0.32121421 |
92 | RPS6KB1 | 0.30164048 |
93 | CDK1 | 0.28880927 |
94 | PRKDC | 0.26885064 |
95 | PRKCI | 0.26641965 |
96 | MST1R | 0.26444019 |
97 | STK4 | 0.25651145 |
98 | DAPK1 | 0.24400970 |
99 | ALK | 0.22782570 |
100 | CDK8 | 0.22762949 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Proteasome_Homo sapiens_hsa03050 | 4.34243220 |
2 | * Protein export_Homo sapiens_hsa03060 | 3.74102241 |
3 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.66301161 |
4 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.54368762 |
5 | Steroid biosynthesis_Homo sapiens_hsa00100 | 2.52211507 |
6 | Mismatch repair_Homo sapiens_hsa03430 | 2.51156686 |
7 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 2.49248623 |
8 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.44391839 |
9 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.15705731 |
10 | Sulfur metabolism_Homo sapiens_hsa00920 | 2.09832889 |
11 | RNA transport_Homo sapiens_hsa03013 | 2.08231317 |
12 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.05356588 |
13 | Spliceosome_Homo sapiens_hsa03040 | 2.01760831 |
14 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.99893473 |
15 | DNA replication_Homo sapiens_hsa03030 | 1.98232435 |
16 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.95017379 |
17 | Basal transcription factors_Homo sapiens_hsa03022 | 1.86036489 |
18 | RNA polymerase_Homo sapiens_hsa03020 | 1.80284187 |
19 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 1.76949665 |
20 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.76238800 |
21 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.69465897 |
22 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.69178091 |
23 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.66363946 |
24 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.65121006 |
25 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.64972051 |
26 | Homologous recombination_Homo sapiens_hsa03440 | 1.62401317 |
27 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.59270469 |
28 | RNA degradation_Homo sapiens_hsa03018 | 1.58733528 |
29 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.57134312 |
30 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.43850446 |
31 | Base excision repair_Homo sapiens_hsa03410 | 1.43158512 |
32 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.43116365 |
33 | Parkinsons disease_Homo sapiens_hsa05012 | 1.39398415 |
34 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.36073188 |
35 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.35226934 |
36 | Carbon metabolism_Homo sapiens_hsa01200 | 1.33653044 |
37 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 1.28725950 |
38 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.21866338 |
39 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.19007944 |
40 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.18936104 |
41 | Cell cycle_Homo sapiens_hsa04110 | 1.18855206 |
42 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.18400373 |
43 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.16666844 |
44 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.14359241 |
45 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.13630379 |
46 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.13580709 |
47 | Huntingtons disease_Homo sapiens_hsa05016 | 1.11213594 |
48 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.08198497 |
49 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.08132693 |
50 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.05317891 |
51 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.92590622 |
52 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.90197293 |
53 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.89369228 |
54 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.89289677 |
55 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.88579986 |
56 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.88024430 |
57 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.87283832 |
58 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.85579240 |
59 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.84837627 |
60 | Peroxisome_Homo sapiens_hsa04146 | 0.83184802 |
61 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.79684312 |
62 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.78586214 |
63 | Purine metabolism_Homo sapiens_hsa00230 | 0.78124690 |
64 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.76924590 |
65 | Alzheimers disease_Homo sapiens_hsa05010 | 0.72297948 |
66 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.70008117 |
67 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.69349447 |
68 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.69151547 |
69 | Legionellosis_Homo sapiens_hsa05134 | 0.68508328 |
70 | Metabolic pathways_Homo sapiens_hsa01100 | 0.68260151 |
71 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.66689316 |
72 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.61666054 |
73 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.61555555 |
74 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.61165150 |
75 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.55233999 |
76 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.53665297 |
77 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.52465004 |
78 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.49408566 |
79 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.47084770 |
80 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.46384426 |
81 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.46185452 |
82 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.43884941 |
83 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.43695047 |
84 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.40221892 |
85 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.38792526 |
86 | Ribosome_Homo sapiens_hsa03010 | 0.38456629 |
87 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.30638776 |
88 | Retinol metabolism_Homo sapiens_hsa00830 | 0.30605736 |
89 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.28345479 |
90 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.27301223 |
91 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.26681723 |
92 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.26471867 |
93 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.25066702 |
94 | Circadian rhythm_Homo sapiens_hsa04710 | 0.24981356 |
95 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.23788913 |
96 | Galactose metabolism_Homo sapiens_hsa00052 | 0.22223085 |
97 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.21326427 |
98 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.20836062 |
99 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.19869391 |
100 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.19840093 |