ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.67409299
2	ATP synthesis coupled proton transport (GO:0015986)	5.13355266
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.13355266
4	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.83599954
5	NADH dehydrogenase complex assembly (GO:0010257)	4.83599954
6	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.83599954
7	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.75008518
8	protein complex biogenesis (GO:0070271)	4.59882229
9	mitochondrial respiratory chain complex assembly (GO:0033108)	4.47535834
10	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.26059375
11	chaperone-mediated protein transport (GO:0072321)	4.14676994
12	DNA double-strand break processing (GO:0000729)	3.83846738
13	ubiquinone biosynthetic process (GO:0006744)	3.78042040
14	rRNA modification (GO:0000154)	3.77619729
15	respiratory electron transport chain (GO:0022904)	3.73137830
16	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.71948226
17	electron transport chain (GO:0022900)	3.71026781
18	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.63699292
19	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.59382596
20	termination of RNA polymerase III transcription (GO:0006386)	3.59382596
21	ribosomal small subunit assembly (GO:0000028)	3.53712632
22	protein-cofactor linkage (GO:0018065)	3.52947000
23	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.51694775
24	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.51694775
25	rRNA methylation (GO:0031167)	3.50295751
26	ubiquinone metabolic process (GO:0006743)	3.48085593
27	epithelial cilium movement (GO:0003351)	3.40461751
28	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.39612436
29	DNA integration (GO:0015074)	3.37897455
30	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.34348199
31	regulation of mitotic spindle checkpoint (GO:1903504)	3.34348199
32	behavioral response to nicotine (GO:0035095)	3.34105523
33	respiratory chain complex IV assembly (GO:0008535)	3.28861132
34	replication fork processing (GO:0031297)	3.28527739
35	DNA deamination (GO:0045006)	3.22071631
36	inner mitochondrial membrane organization (GO:0007007)	3.19816229
37	positive regulation of protein homodimerization activity (GO:0090073)	3.19542161
38	chromatin remodeling at centromere (GO:0031055)	3.18567322
39	protein neddylation (GO:0045116)	3.16753079
40	quinone biosynthetic process (GO:1901663)	3.14551061
41	regulation of cilium movement (GO:0003352)	3.13303992
42	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.10382829
43	GTP biosynthetic process (GO:0006183)	3.08485357
44	water-soluble vitamin biosynthetic process (GO:0042364)	3.07982872
45	intracellular protein transmembrane import (GO:0044743)	3.07866206
46	maturation of 5.8S rRNA (GO:0000460)	3.06727809
47	ribosomal small subunit biogenesis (GO:0042274)	3.05351621
48	CENP-A containing nucleosome assembly (GO:0034080)	3.02786832
49	peptidyl-histidine modification (GO:0018202)	3.02666449
50	response to pheromone (GO:0019236)	3.00725575
51	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.99908555
52	ATP biosynthetic process (GO:0006754)	2.97200091
53	protein targeting to mitochondrion (GO:0006626)	2.92942212
54	viral transcription (GO:0019083)	2.89804005
55	translational termination (GO:0006415)	2.89683574
56	cytochrome complex assembly (GO:0017004)	2.89367563
57	tRNA processing (GO:0008033)	2.88835438
58	platelet dense granule organization (GO:0060155)	2.88674332
59	resolution of meiotic recombination intermediates (GO:0000712)	2.87492394
60	cullin deneddylation (GO:0010388)	2.86068414
61	histone exchange (GO:0043486)	2.85205299
62	mannosylation (GO:0097502)	2.83838756
63	maturation of SSU-rRNA (GO:0030490)	2.80812363
64	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.80661414
65	establishment of protein localization to mitochondrion (GO:0072655)	2.79225867
66	protein localization to mitochondrion (GO:0070585)	2.78849219
67	cotranslational protein targeting to membrane (GO:0006613)	2.78128972
68	protein targeting to ER (GO:0045047)	2.77839719
69	intraciliary transport (GO:0042073)	2.77605524
70	cellular ketone body metabolic process (GO:0046950)	2.77428053
71	cellular component biogenesis (GO:0044085)	2.77056638
72	proteasome assembly (GO:0043248)	2.76035923
73	centriole replication (GO:0007099)	2.73486741
74	kinetochore assembly (GO:0051382)	2.73252295
75	neural tube formation (GO:0001841)	2.72765760
76	translation (GO:0006412)	2.70072526
77	hydrogen ion transmembrane transport (GO:1902600)	2.69433357
78	L-fucose catabolic process (GO:0042355)	2.68438311
79	fucose catabolic process (GO:0019317)	2.68438311
80	L-fucose metabolic process (GO:0042354)	2.68438311
81	7-methylguanosine mRNA capping (GO:0006370)	2.68145329
82	synapsis (GO:0007129)	2.65865992
83	protein polyglutamylation (GO:0018095)	2.65454359
84	protein localization to endoplasmic reticulum (GO:0070972)	2.65340916
85	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.61729796
86	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.61574530
87	7-methylguanosine RNA capping (GO:0009452)	2.61035998
88	RNA capping (GO:0036260)	2.61035998
89	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.58766896
90	preassembly of GPI anchor in ER membrane (GO:0016254)	2.58521141
91	recombinational repair (GO:0000725)	2.57310355
92	indole-containing compound catabolic process (GO:0042436)	2.57207551
93	indolalkylamine catabolic process (GO:0046218)	2.57207551
94	tryptophan catabolic process (GO:0006569)	2.57207551
95	negative regulation of telomere maintenance (GO:0032205)	2.57180053
96	ribosomal large subunit biogenesis (GO:0042273)	2.56899833
97	pseudouridine synthesis (GO:0001522)	2.55570069
98	translational elongation (GO:0006414)	2.54336176
99	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.53673479
100	cilium movement (GO:0003341)	2.53380397

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.29555807
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.28423213
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	4.01505341
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.64340332
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.60418549
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.34031211
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.25279466
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.92925541
9	ELK1_19687146_ChIP-ChIP_HELA_Human	2.66958322
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.64798010
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.64404911
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.60261183
13	VDR_22108803_ChIP-Seq_LS180_Human	2.44209660
14	IGF1R_20145208_ChIP-Seq_DFB_Human	2.38222202
15	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.37056958
16	FUS_26573619_Chip-Seq_HEK293_Human	2.25229733
17	FOXP3_21729870_ChIP-Seq_TREG_Human	2.12662659
18	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.10562747
19	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.09475252
20	EWS_26573619_Chip-Seq_HEK293_Human	2.06981064
21	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.00208081
22	MYC_18940864_ChIP-ChIP_HL60_Human	1.91980589
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.87808302
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.87434405
25	GBX2_23144817_ChIP-Seq_PC3_Human	1.86516980
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.85571747
27	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.83652012
28	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.74897942
29	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.72292161
30	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.69510318
31	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.68969353
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.66474763
33	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.63732681
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.60419277
35	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.60131666
36	P300_19829295_ChIP-Seq_ESCs_Human	1.58209226
37	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.55363612
38	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.50136409
39	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.49876789
40	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.48224857
41	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.46301499
42	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.46275473
43	ER_23166858_ChIP-Seq_MCF-7_Human	1.43944879
44	EZH2_22144423_ChIP-Seq_EOC_Human	1.41295889
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.38868166
46	GABP_19822575_ChIP-Seq_HepG2_Human	1.37534054
47	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.33714439
48	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.33655098
49	DCP1A_22483619_ChIP-Seq_HELA_Human	1.31020053
50	TP53_22573176_ChIP-Seq_HFKS_Human	1.30475905
51	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.30379496
52	TTF2_22483619_ChIP-Seq_HELA_Human	1.29386794
53	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.26023254
54	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.25874955
55	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.24259395
56	TAF15_26573619_Chip-Seq_HEK293_Human	1.19154644
57	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.18762172
58	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.18762172
59	CBP_20019798_ChIP-Seq_JUKART_Human	1.14060832
60	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.14060832
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.13768267
62	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.12987261
63	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.11857723
64	NANOG_19829295_ChIP-Seq_ESCs_Human	1.09974440
65	SOX2_19829295_ChIP-Seq_ESCs_Human	1.09974440
66	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.08653604
67	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.08631583
68	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.05669486
69	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.05107894
70	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.05038474
71	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.04218186
72	E2F7_22180533_ChIP-Seq_HELA_Human	1.04026898
73	XRN2_22483619_ChIP-Seq_HELA_Human	1.03215840
74	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02613825
75	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.01514485
76	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.99919808
77	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.99114479
78	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.96634159
79	NCOR_22424771_ChIP-Seq_293T_Human	0.96278934
80	AR_20517297_ChIP-Seq_VCAP_Human	0.94706479
81	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.93294538
82	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.91959288
83	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.91386999
84	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.91102515
85	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.91102515
86	NANOG_20526341_ChIP-Seq_ESCs_Human	0.90588215
87	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.89653282
88	BCAT_22108803_ChIP-Seq_LS180_Human	0.89277002
89	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.88387867
90	HTT_18923047_ChIP-ChIP_STHdh_Human	0.88024895
91	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.87564041
92	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.87203971
93	TCF4_22108803_ChIP-Seq_LS180_Human	0.87041792
94	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.86054354
95	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.86025251
96	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.85064324
97	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.84447322
98	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.83893634
99	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.82526259
100	MYC_19829295_ChIP-Seq_ESCs_Human	0.81529911

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001529_abnormal_vocalization	2.92315777
2	MP0006292_abnormal_olfactory_placode	2.57524916
3	MP0003880_abnormal_central_pattern	2.55246239
4	MP0003806_abnormal_nucleotide_metabolis	2.53815076
5	MP0001764_abnormal_homeostasis	2.33264179
6	MP0008877_abnormal_DNA_methylation	2.24622145
7	MP0008058_abnormal_DNA_repair	2.08477668
8	MP0006072_abnormal_retinal_apoptosis	2.01469396
9	MP0005410_abnormal_fertilization	1.99367693
10	MP0002837_dystrophic_cardiac_calcinosis	1.97218765
11	MP0002102_abnormal_ear_morphology	1.97088636
12	MP0003718_maternal_effect	1.95541810
13	MP0005646_abnormal_pituitary_gland	1.94992242
14	MP0003195_calcinosis	1.85368734
15	MP0009697_abnormal_copulation	1.83584063
16	MP0002938_white_spotting	1.80551358
17	MP0000569_abnormal_digit_pigmentation	1.77832167
18	MP0001968_abnormal_touch/_nociception	1.77059274
19	MP0008875_abnormal_xenobiotic_pharmacok	1.76684445
20	MP0003136_yellow_coat_color	1.75940070
21	MP0001984_abnormal_olfaction	1.75792777
22	MP0002736_abnormal_nociception_after	1.74985618
23	MP0010094_abnormal_chromosome_stability	1.71747932
24	MP0005253_abnormal_eye_physiology	1.67393814
25	MP0009379_abnormal_foot_pigmentation	1.66911433
26	MP0003315_abnormal_perineum_morphology	1.61646917
27	MP0000631_abnormal_neuroendocrine_gland	1.60311526
28	MP0003693_abnormal_embryo_hatching	1.60176566
29	MP0005551_abnormal_eye_electrophysiolog	1.59259829
30	MP0005174_abnormal_tail_pigmentation	1.59068811
31	MP0002277_abnormal_respiratory_mucosa	1.57822282
32	MP0008789_abnormal_olfactory_epithelium	1.55996530
33	MP0008872_abnormal_physiological_respon	1.53695327
34	MP0002160_abnormal_reproductive_system	1.53478037
35	MP0004142_abnormal_muscle_tone	1.45692712
36	MP0006035_abnormal_mitochondrial_morpho	1.45530111
37	MP0006036_abnormal_mitochondrial_physio	1.45291022
38	MP0001929_abnormal_gametogenesis	1.44359936
39	MP0006276_abnormal_autonomic_nervous	1.42790528
40	MP0003186_abnormal_redox_activity	1.42180984
41	MP0004133_heterotaxia	1.42081785
42	MP0002653_abnormal_ependyma_morphology	1.41457261
43	MP0002638_abnormal_pupillary_reflex	1.40262599
44	MP0008057_abnormal_DNA_replication	1.36923126
45	MP0005084_abnormal_gallbladder_morpholo	1.35901999
46	MP0002210_abnormal_sex_determination	1.35277882
47	MP0002132_abnormal_respiratory_system	1.33168561
48	MP0005499_abnormal_olfactory_system	1.30661152
49	MP0005394_taste/olfaction_phenotype	1.30661152
50	MP0003567_abnormal_fetal_cardiomyocyte	1.29933215
51	MP0001485_abnormal_pinna_reflex	1.28884735
52	MP0009046_muscle_twitch	1.28617596
53	MP0003698_abnormal_male_reproductive	1.27121303
54	MP0001905_abnormal_dopamine_level	1.25488364
55	MP0009745_abnormal_behavioral_response	1.24242919
56	MP0008995_early_reproductive_senescence	1.21208736
57	MP0005645_abnormal_hypothalamus_physiol	1.15821396
58	MP0008007_abnormal_cellular_replicative	1.14295612
59	MP0001293_anophthalmia	1.13924213
60	MP0000372_irregular_coat_pigmentation	1.11722905
61	MP0005389_reproductive_system_phenotype	1.11175780
62	MP0001145_abnormal_male_reproductive	1.10255716
63	MP0000653_abnormal_sex_gland	1.09956972
64	MP0001919_abnormal_reproductive_system	1.05004341
65	MP0002272_abnormal_nervous_system	1.03738182
66	MP0002095_abnormal_skin_pigmentation	1.00856381
67	MP0003937_abnormal_limbs/digits/tail_de	0.98977865
68	MP0000566_synostosis	0.98828455
69	MP0005332_abnormal_amino_acid	0.97812823
70	MP0003011_delayed_dark_adaptation	0.97110393
71	MP0002751_abnormal_autonomic_nervous	0.97100064
72	MP0003121_genomic_imprinting	0.97091598
73	MP0000049_abnormal_middle_ear	0.95726286
74	MP0005365_abnormal_bile_salt	0.94308842
75	MP0003122_maternal_imprinting	0.92527316
76	MP0003077_abnormal_cell_cycle	0.92012727
77	MP0003786_premature_aging	0.91308425
78	MP0001188_hyperpigmentation	0.91235798
79	MP0004145_abnormal_muscle_electrophysio	0.91080342
80	MP0002557_abnormal_social/conspecific_i	0.85300390
81	MP0005085_abnormal_gallbladder_physiolo	0.83371482
82	MP0005391_vision/eye_phenotype	0.82351861
83	MP0003938_abnormal_ear_development	0.81769559
84	MP0002163_abnormal_gland_morphology	0.81180394
85	MP0001986_abnormal_taste_sensitivity	0.81032002
86	MP0003787_abnormal_imprinting	0.80926394
87	MP0005266_abnormal_metabolism	0.80881906
88	MP0003252_abnormal_bile_duct	0.80603213
89	MP0005195_abnormal_posterior_eye	0.74807288
90	MP0002233_abnormal_nose_morphology	0.74077476
91	MP0002184_abnormal_innervation	0.72273255
92	MP0004957_abnormal_blastocyst_morpholog	0.72220685
93	MP0002752_abnormal_somatic_nervous	0.72042764
94	MP0004134_abnormal_chest_morphology	0.71382077
95	MP0000647_abnormal_sebaceous_gland	0.71019351
96	MP0003119_abnormal_digestive_system	0.70949370
97	MP0002067_abnormal_sensory_capabilities	0.70519926
98	MP0003111_abnormal_nucleus_morphology	0.70215669
99	MP0000026_abnormal_inner_ear	0.70106780
100	MP0000427_abnormal_hair_cycle	0.69849144

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.33450444
2	Acute encephalopathy (HP:0006846)	3.93555694
3	Abnormal mitochondria in muscle tissue (HP:0008316)	3.88122445
4	Mitochondrial inheritance (HP:0001427)	3.80333242
5	Pancreatic cysts (HP:0001737)	3.58794268
6	Progressive macrocephaly (HP:0004481)	3.55590029
7	3-Methylglutaconic aciduria (HP:0003535)	3.47341930
8	Hepatocellular necrosis (HP:0001404)	3.37317463
9	Increased CSF lactate (HP:0002490)	3.36149963
10	Abnormality of midbrain morphology (HP:0002418)	3.23427078
11	Molar tooth sign on MRI (HP:0002419)	3.23427078
12	Pancreatic fibrosis (HP:0100732)	3.23173406
13	Reduced antithrombin III activity (HP:0001976)	3.16794211
14	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.16470048
15	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.16470048
16	True hermaphroditism (HP:0010459)	3.12575957
17	Type I transferrin isoform profile (HP:0003642)	3.12337096
18	Hepatic necrosis (HP:0002605)	3.10999856
19	Abnormal protein N-linked glycosylation (HP:0012347)	3.10247399
20	Abnormal protein glycosylation (HP:0012346)	3.10247399
21	Abnormal glycosylation (HP:0012345)	3.10247399
22	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.10247399
23	Lipid accumulation in hepatocytes (HP:0006561)	3.01698692
24	Nephronophthisis (HP:0000090)	2.84620583
25	Cerebral edema (HP:0002181)	2.82806927
26	Methylmalonic acidemia (HP:0002912)	2.80887070
27	Increased hepatocellular lipid droplets (HP:0006565)	2.73268372
28	Hyperglycinemia (HP:0002154)	2.71880493
29	Meckel diverticulum (HP:0002245)	2.62901702
30	Intestinal atresia (HP:0011100)	2.60804160
31	Aplasia/hypoplasia of the uterus (HP:0008684)	2.59361049
32	Type II lissencephaly (HP:0007260)	2.59004008
33	Colon cancer (HP:0003003)	2.58055709
34	Abnormality of the ileum (HP:0001549)	2.56397594
35	Increased serum lactate (HP:0002151)	2.53372163
36	Abnormal biliary tract physiology (HP:0012439)	2.46365953
37	Bile duct proliferation (HP:0001408)	2.46365953
38	Methylmalonic aciduria (HP:0012120)	2.45652369
39	Lactic acidosis (HP:0003128)	2.42738336
40	Abnormality of the renal medulla (HP:0100957)	2.42229435
41	Abnormal number of erythroid precursors (HP:0012131)	2.39450235
42	Renal Fanconi syndrome (HP:0001994)	2.39261889
43	Congenital stationary night blindness (HP:0007642)	2.36686465
44	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.36605597
45	Medial flaring of the eyebrow (HP:0010747)	2.34072738
46	Hyperglycinuria (HP:0003108)	2.33476648
47	Absent thumb (HP:0009777)	2.32807064
48	Abnormality of the renal cortex (HP:0011035)	2.29329845
49	Renal cortical cysts (HP:0000803)	2.27592612
50	Cerebellar dysplasia (HP:0007033)	2.26588962
51	Optic disc pallor (HP:0000543)	2.23929802
52	Abnormality of methionine metabolism (HP:0010901)	2.21465856
53	Chronic hepatic failure (HP:0100626)	2.20746779
54	Pendular nystagmus (HP:0012043)	2.19308827
55	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.17470140
56	Absent/shortened dynein arms (HP:0200106)	2.17470140
57	Reticulocytopenia (HP:0001896)	2.15584779
58	Abnormality of serine family amino acid metabolism (HP:0010894)	2.15006287
59	Abnormality of glycine metabolism (HP:0010895)	2.15006287
60	Gastrointestinal atresia (HP:0002589)	2.14300923
61	Hypothermia (HP:0002045)	2.13940589
62	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.10837393
63	Abnormality of alanine metabolism (HP:0010916)	2.10837393
64	Hyperalaninemia (HP:0003348)	2.10837393
65	Male pseudohermaphroditism (HP:0000037)	2.10804291
66	Lethargy (HP:0001254)	2.10208854
67	Congenital, generalized hypertrichosis (HP:0004540)	2.08398602
68	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.07286793
69	Abnormality of cells of the erythroid lineage (HP:0012130)	2.07231222
70	Macrocytic anemia (HP:0001972)	2.06684036
71	Increased intramyocellular lipid droplets (HP:0012240)	2.05672403
72	Respiratory failure (HP:0002878)	2.04807897
73	Cystic liver disease (HP:0006706)	2.04195933
74	Hypoplasia of the pons (HP:0012110)	2.01968106
75	Abnormality of the preputium (HP:0100587)	1.99516341
76	Abnormal ciliary motility (HP:0012262)	1.99469258
77	Abnormal respiratory motile cilium morphology (HP:0005938)	1.98550270
78	Abnormal respiratory epithelium morphology (HP:0012253)	1.98550270
79	Abolished electroretinogram (ERG) (HP:0000550)	1.97761852
80	Tubulointerstitial nephritis (HP:0001970)	1.97223107
81	Short tibia (HP:0005736)	1.96933508
82	Exertional dyspnea (HP:0002875)	1.95075084
83	Abnormality of serum amino acid levels (HP:0003112)	1.94975163
84	Hypoplasia of the uterus (HP:0000013)	1.94591287
85	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.93565161
86	Abnormality of DNA repair (HP:0003254)	1.92775590
87	Generalized aminoaciduria (HP:0002909)	1.90683864
88	Increased muscle lipid content (HP:0009058)	1.90418408
89	Abnormality of the pons (HP:0007361)	1.89318369
90	Congenital primary aphakia (HP:0007707)	1.88830394
91	Median cleft lip (HP:0000161)	1.87211748
92	Abnormality of the labia minora (HP:0012880)	1.86876168
93	Constricted visual fields (HP:0001133)	1.85009664
94	Exercise intolerance (HP:0003546)	1.83265818
95	Abnormal respiratory motile cilium physiology (HP:0012261)	1.82233962
96	Gait imbalance (HP:0002141)	1.81864978
97	Leukodystrophy (HP:0002415)	1.81850506
98	Abnormality of chromosome stability (HP:0003220)	1.81281470
99	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.80775731
100	Abnormal rod and cone electroretinograms (HP:0008323)	1.79167199

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	4.43077132
2	ZAK	3.33337476
3	BMPR1B	3.19758895
4	PINK1	3.06271794
5	STK16	2.89069590
6	MAP4K2	2.77962538
7	VRK2	2.64832817
8	VRK1	2.51149103
9	MST4	2.21073734
10	WNK3	2.20808177
11	TNIK	2.01863983
12	FRK	2.01492677
13	NUAK1	1.99902483
14	ADRBK2	1.98166331
15	TAF1	1.93020351
16	BUB1	1.81057396
17	TLK1	1.76162112
18	INSRR	1.74753434
19	EIF2AK1	1.68678609
20	MAP2K7	1.63134205
21	SRPK1	1.52293583
22	PBK	1.50863959
23	GRK1	1.48338411
24	EIF2AK3	1.45550294
25	BCKDK	1.43165718
26	PLK4	1.42088568
27	PLK3	1.35812847
28	MAPK13	1.33389457
29	MARK3	1.33070744
30	ACVR1B	1.32752586
31	MAP3K4	1.32499455
32	DYRK2	1.25307049
33	TNK2	1.24070930
34	NME1	1.23912151
35	MKNK2	1.18379305
36	WEE1	1.17626884
37	MUSK	1.13133477
38	CDC7	1.10982214
39	STK38L	1.09864663
40	OXSR1	1.07685191
41	PNCK	1.03785663
42	TRIM28	1.00113260
43	WNK4	0.97653652
44	BRSK2	0.97517643
45	CDK19	0.97094101
46	CDK3	0.95273952
47	PLK2	0.94107833
48	CSNK1G3	0.92979026
49	GRK5	0.88571791
50	TSSK6	0.88398503
51	EPHA4	0.85265196
52	NEK2	0.81884322
53	MKNK1	0.80158737
54	PLK1	0.79013286
55	CSNK1G2	0.78481163
56	STK39	0.76144216
57	PASK	0.74783562
58	CSNK1G1	0.74746407
59	MAPKAPK3	0.74589103
60	PRKCG	0.73832374
61	MAPK15	0.70649507
62	DYRK3	0.69467701
63	IRAK2	0.69418677
64	RPS6KA5	0.69079939
65	TGFBR1	0.68242240
66	NLK	0.67488640
67	CSNK1A1L	0.65803032
68	TXK	0.64411003
69	OBSCN	0.62745082
70	PRKCE	0.59722430
71	PRKCQ	0.57352779
72	ATR	0.52232128
73	CHEK2	0.50627583
74	AURKB	0.49640011
75	ADRBK1	0.48381666
76	CSNK2A1	0.44211641
77	MYLK	0.43659779
78	PAK3	0.43287529
79	TTK	0.42446627
80	RPS6KA4	0.40885320
81	ATM	0.40429397
82	GRK6	0.39380670
83	CSNK2A2	0.39034400
84	STK4	0.38688287
85	BCR	0.36219754
86	PHKG1	0.35633657
87	PHKG2	0.35633657
88	NME2	0.35471073
89	CASK	0.35083039
90	CSNK1A1	0.34437035
91	CCNB1	0.34064921
92	CAMK1	0.33251856
93	PTK2B	0.32123804
94	IKBKB	0.31779214
95	MAPKAPK5	0.31745873
96	IRAK1	0.29892467
97	TIE1	0.29820752
98	DAPK1	0.29172301
99	CSNK1E	0.28331682
100	AURKA	0.27394165

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.63640219
2	Ribosome_Homo sapiens_hsa03010	3.30627683
3	Parkinsons disease_Homo sapiens_hsa05012	3.14458702
4	RNA polymerase_Homo sapiens_hsa03020	3.06015709
5	Proteasome_Homo sapiens_hsa03050	2.89285063
6	Protein export_Homo sapiens_hsa03060	2.61127845
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.47681017
8	Homologous recombination_Homo sapiens_hsa03440	2.27212628
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.21407954
10	Huntingtons disease_Homo sapiens_hsa05016	2.14241229
11	Alzheimers disease_Homo sapiens_hsa05010	2.05478648
12	RNA degradation_Homo sapiens_hsa03018	1.95266246
13	One carbon pool by folate_Homo sapiens_hsa00670	1.90630132
14	Fanconi anemia pathway_Homo sapiens_hsa03460	1.90108101
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.88262070
16	Basal transcription factors_Homo sapiens_hsa03022	1.85969124
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.81159938
18	Propanoate metabolism_Homo sapiens_hsa00640	1.78028664
19	DNA replication_Homo sapiens_hsa03030	1.73384347
20	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.66473945
21	Mismatch repair_Homo sapiens_hsa03430	1.65255122
22	Pyrimidine metabolism_Homo sapiens_hsa00240	1.65229170
23	Butanoate metabolism_Homo sapiens_hsa00650	1.59845625
24	Nucleotide excision repair_Homo sapiens_hsa03420	1.56140838
25	Spliceosome_Homo sapiens_hsa03040	1.41652118
26	Purine metabolism_Homo sapiens_hsa00230	1.39551105
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.38688771
28	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.36316960
29	RNA transport_Homo sapiens_hsa03013	1.31802368
30	Phototransduction_Homo sapiens_hsa04744	1.31577994
31	Base excision repair_Homo sapiens_hsa03410	1.30687868
32	Peroxisome_Homo sapiens_hsa04146	1.30124237
33	Selenocompound metabolism_Homo sapiens_hsa00450	1.28152966
34	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.25574524
35	Linoleic acid metabolism_Homo sapiens_hsa00591	1.23420923
36	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.22992073
37	Cardiac muscle contraction_Homo sapiens_hsa04260	1.22469171
38	Nitrogen metabolism_Homo sapiens_hsa00910	1.17848236
39	Chemical carcinogenesis_Homo sapiens_hsa05204	1.17640917
40	Caffeine metabolism_Homo sapiens_hsa00232	1.17384775
41	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.14667055
42	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.14622121
43	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.12968304
44	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.12125549
45	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.06695537
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.02217543
47	Folate biosynthesis_Homo sapiens_hsa00790	1.00639706
48	Steroid biosynthesis_Homo sapiens_hsa00100	1.00395092
49	Tryptophan metabolism_Homo sapiens_hsa00380	0.97530542
50	Non-homologous end-joining_Homo sapiens_hsa03450	0.95035618
51	Regulation of autophagy_Homo sapiens_hsa04140	0.94953914
52	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.94930732
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.94469349
54	Metabolic pathways_Homo sapiens_hsa01100	0.94072069
55	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.93865999
56	Olfactory transduction_Homo sapiens_hsa04740	0.93309089
57	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.91554260
58	Sulfur metabolism_Homo sapiens_hsa00920	0.91059579
59	Glutathione metabolism_Homo sapiens_hsa00480	0.87072699
60	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.85899922
61	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.82592078
62	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.80782924
63	Retinol metabolism_Homo sapiens_hsa00830	0.80011599
64	beta-Alanine metabolism_Homo sapiens_hsa00410	0.79175894
65	Ether lipid metabolism_Homo sapiens_hsa00565	0.73926744
66	Pyruvate metabolism_Homo sapiens_hsa00620	0.73535392
67	Nicotine addiction_Homo sapiens_hsa05033	0.72902638
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.71957558
69	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.71920578
70	Mineral absorption_Homo sapiens_hsa04978	0.71665148
71	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.70917729
72	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.69254693
73	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.68375799
74	Fat digestion and absorption_Homo sapiens_hsa04975	0.61709612
75	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.61491507
76	Fatty acid degradation_Homo sapiens_hsa00071	0.55936323
77	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.53326191
78	Taste transduction_Homo sapiens_hsa04742	0.53050884
79	Fatty acid elongation_Homo sapiens_hsa00062	0.52653172
80	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.52643323
81	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.48028489
82	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.47293159
83	Sulfur relay system_Homo sapiens_hsa04122	0.47118532
84	p53 signaling pathway_Homo sapiens_hsa04115	0.46302754
85	Collecting duct acid secretion_Homo sapiens_hsa04966	0.45560763
86	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.42198775
87	Arginine and proline metabolism_Homo sapiens_hsa00330	0.40646170
88	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.40108554
89	Oocyte meiosis_Homo sapiens_hsa04114	0.36609090
90	mRNA surveillance pathway_Homo sapiens_hsa03015	0.36600951
91	Primary immunodeficiency_Homo sapiens_hsa05340	0.36301379
92	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.35069734
93	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.34512451
94	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.34373760
95	Cell cycle_Homo sapiens_hsa04110	0.33961287
96	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.25643063
97	Glycerolipid metabolism_Homo sapiens_hsa00561	0.25248329
98	Fatty acid metabolism_Homo sapiens_hsa01212	0.24106253
99	Circadian rhythm_Homo sapiens_hsa04710	0.23555037
100	Tyrosine metabolism_Homo sapiens_hsa00350	0.21000677

SRP54-AS1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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