SRP54-AS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.67409299
2ATP synthesis coupled proton transport (GO:0015986)5.13355266
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.13355266
4mitochondrial respiratory chain complex I assembly (GO:0032981)4.83599954
5NADH dehydrogenase complex assembly (GO:0010257)4.83599954
6mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.83599954
7establishment of protein localization to mitochondrial membrane (GO:0090151)4.75008518
8protein complex biogenesis (GO:0070271)4.59882229
9mitochondrial respiratory chain complex assembly (GO:0033108)4.47535834
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.26059375
11chaperone-mediated protein transport (GO:0072321)4.14676994
12DNA double-strand break processing (GO:0000729)3.83846738
13ubiquinone biosynthetic process (GO:0006744)3.78042040
14rRNA modification (GO:0000154)3.77619729
15respiratory electron transport chain (GO:0022904)3.73137830
16nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.71948226
17electron transport chain (GO:0022900)3.71026781
18exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.63699292
19transcription elongation from RNA polymerase III promoter (GO:0006385)3.59382596
20termination of RNA polymerase III transcription (GO:0006386)3.59382596
21ribosomal small subunit assembly (GO:0000028)3.53712632
22protein-cofactor linkage (GO:0018065)3.52947000
23tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.51694775
24RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.51694775
25rRNA methylation (GO:0031167)3.50295751
26ubiquinone metabolic process (GO:0006743)3.48085593
27epithelial cilium movement (GO:0003351)3.40461751
28epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.39612436
29DNA integration (GO:0015074)3.37897455
30regulation of mitotic spindle checkpoint (GO:1903504)3.34348199
31regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.34348199
32behavioral response to nicotine (GO:0035095)3.34105523
33respiratory chain complex IV assembly (GO:0008535)3.28861132
34replication fork processing (GO:0031297)3.28527739
35DNA deamination (GO:0045006)3.22071631
36inner mitochondrial membrane organization (GO:0007007)3.19816229
37positive regulation of protein homodimerization activity (GO:0090073)3.19542161
38chromatin remodeling at centromere (GO:0031055)3.18567322
39protein neddylation (GO:0045116)3.16753079
40quinone biosynthetic process (GO:1901663)3.14551061
41regulation of cilium movement (GO:0003352)3.13303992
42purine nucleoside triphosphate biosynthetic process (GO:0009145)3.10382829
43GTP biosynthetic process (GO:0006183)3.08485357
44water-soluble vitamin biosynthetic process (GO:0042364)3.07982872
45intracellular protein transmembrane import (GO:0044743)3.07866206
46maturation of 5.8S rRNA (GO:0000460)3.06727809
47ribosomal small subunit biogenesis (GO:0042274)3.05351621
48CENP-A containing nucleosome assembly (GO:0034080)3.02786832
49peptidyl-histidine modification (GO:0018202)3.02666449
50response to pheromone (GO:0019236)3.00725575
51purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.99908555
52ATP biosynthetic process (GO:0006754)2.97200091
53protein targeting to mitochondrion (GO:0006626)2.92942212
54viral transcription (GO:0019083)2.89804005
55translational termination (GO:0006415)2.89683574
56cytochrome complex assembly (GO:0017004)2.89367563
57tRNA processing (GO:0008033)2.88835438
58platelet dense granule organization (GO:0060155)2.88674332
59resolution of meiotic recombination intermediates (GO:0000712)2.87492394
60cullin deneddylation (GO:0010388)2.86068414
61histone exchange (GO:0043486)2.85205299
62mannosylation (GO:0097502)2.83838756
63maturation of SSU-rRNA (GO:0030490)2.80812363
64SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.80661414
65establishment of protein localization to mitochondrion (GO:0072655)2.79225867
66protein localization to mitochondrion (GO:0070585)2.78849219
67cotranslational protein targeting to membrane (GO:0006613)2.78128972
68protein targeting to ER (GO:0045047)2.77839719
69intraciliary transport (GO:0042073)2.77605524
70cellular ketone body metabolic process (GO:0046950)2.77428053
71cellular component biogenesis (GO:0044085)2.77056638
72proteasome assembly (GO:0043248)2.76035923
73centriole replication (GO:0007099)2.73486741
74kinetochore assembly (GO:0051382)2.73252295
75neural tube formation (GO:0001841)2.72765760
76translation (GO:0006412)2.70072526
77hydrogen ion transmembrane transport (GO:1902600)2.69433357
78fucose catabolic process (GO:0019317)2.68438311
79L-fucose metabolic process (GO:0042354)2.68438311
80L-fucose catabolic process (GO:0042355)2.68438311
817-methylguanosine mRNA capping (GO:0006370)2.68145329
82synapsis (GO:0007129)2.65865992
83protein polyglutamylation (GO:0018095)2.65454359
84protein localization to endoplasmic reticulum (GO:0070972)2.65340916
85L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.61729796
86establishment of protein localization to endoplasmic reticulum (GO:0072599)2.61574530
877-methylguanosine RNA capping (GO:0009452)2.61035998
88RNA capping (GO:0036260)2.61035998
89negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.58766896
90preassembly of GPI anchor in ER membrane (GO:0016254)2.58521141
91recombinational repair (GO:0000725)2.57310355
92tryptophan catabolic process (GO:0006569)2.57207551
93indole-containing compound catabolic process (GO:0042436)2.57207551
94indolalkylamine catabolic process (GO:0046218)2.57207551
95negative regulation of telomere maintenance (GO:0032205)2.57180053
96ribosomal large subunit biogenesis (GO:0042273)2.56899833
97pseudouridine synthesis (GO:0001522)2.55570069
98translational elongation (GO:0006414)2.54336176
99ribonucleoside triphosphate biosynthetic process (GO:0009201)2.53673479
100cilium movement (GO:0003341)2.53380397

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.29555807
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.28423213
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.01505341
4ZNF274_21170338_ChIP-Seq_K562_Hela3.64340332
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.60418549
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.34031211
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.25279466
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.92925541
9ELK1_19687146_ChIP-ChIP_HELA_Human2.66958322
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.64798010
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.64404911
12VDR_23849224_ChIP-Seq_CD4+_Human2.60261183
13VDR_22108803_ChIP-Seq_LS180_Human2.44209660
14IGF1R_20145208_ChIP-Seq_DFB_Human2.38222202
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.37056958
16FUS_26573619_Chip-Seq_HEK293_Human2.25229733
17FOXP3_21729870_ChIP-Seq_TREG_Human2.12662659
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.10562747
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.09475252
20EWS_26573619_Chip-Seq_HEK293_Human2.06981064
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.00208081
22MYC_18940864_ChIP-ChIP_HL60_Human1.91980589
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87808302
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.87434405
25GBX2_23144817_ChIP-Seq_PC3_Human1.86516980
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.85571747
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83652012
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.74897942
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.72292161
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69510318
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68969353
32IRF1_19129219_ChIP-ChIP_H3396_Human1.66474763
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.63732681
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60419277
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60131666
36P300_19829295_ChIP-Seq_ESCs_Human1.58209226
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.55363612
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50136409
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49876789
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.48224857
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46301499
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46275473
43ER_23166858_ChIP-Seq_MCF-7_Human1.43944879
44EZH2_22144423_ChIP-Seq_EOC_Human1.41295889
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38868166
46GABP_19822575_ChIP-Seq_HepG2_Human1.37534054
47MYC_18555785_ChIP-Seq_MESCs_Mouse1.33714439
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33655098
49DCP1A_22483619_ChIP-Seq_HELA_Human1.31020053
50TP53_22573176_ChIP-Seq_HFKS_Human1.30475905
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30379496
52TTF2_22483619_ChIP-Seq_HELA_Human1.29386794
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.26023254
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25874955
55FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.24259395
56TAF15_26573619_Chip-Seq_HEK293_Human1.19154644
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18762172
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.18762172
59CBP_20019798_ChIP-Seq_JUKART_Human1.14060832
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14060832
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13768267
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12987261
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11857723
64SOX2_19829295_ChIP-Seq_ESCs_Human1.09974440
65NANOG_19829295_ChIP-Seq_ESCs_Human1.09974440
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08653604
67MYC_18358816_ChIP-ChIP_MESCs_Mouse1.08631583
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.05669486
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05107894
70MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05038474
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04218186
72E2F7_22180533_ChIP-Seq_HELA_Human1.04026898
73XRN2_22483619_ChIP-Seq_HELA_Human1.03215840
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.02613825
75PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.01514485
76CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99919808
77MYC_19030024_ChIP-ChIP_MESCs_Mouse0.99114479
78KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96634159
79NCOR_22424771_ChIP-Seq_293T_Human0.96278934
80AR_20517297_ChIP-Seq_VCAP_Human0.94706479
81ELK1_22589737_ChIP-Seq_MCF10A_Human0.93294538
82SOX2_16153702_ChIP-ChIP_HESCs_Human0.91959288
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91386999
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91102515
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91102515
86NANOG_20526341_ChIP-Seq_ESCs_Human0.90588215
87FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89653282
88BCAT_22108803_ChIP-Seq_LS180_Human0.89277002
89E2F1_18555785_ChIP-Seq_MESCs_Mouse0.88387867
90HTT_18923047_ChIP-ChIP_STHdh_Human0.88024895
91ETV2_25802403_ChIP-Seq_MESCs_Mouse0.87564041
92ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.87203971
93TCF4_22108803_ChIP-Seq_LS180_Human0.87041792
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86054354
95FOXH1_21741376_ChIP-Seq_EPCs_Human0.86025251
96PCGF2_27294783_Chip-Seq_NPCs_Mouse0.85064324
97BMI1_23680149_ChIP-Seq_NPCS_Mouse0.84447322
98EZH2_27294783_Chip-Seq_NPCs_Mouse0.83893634
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82526259
100MYC_19829295_ChIP-Seq_ESCs_Human0.81529911

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization2.92315777
2MP0006292_abnormal_olfactory_placode2.57524916
3MP0003880_abnormal_central_pattern2.55246239
4MP0003806_abnormal_nucleotide_metabolis2.53815076
5MP0001764_abnormal_homeostasis2.33264179
6MP0008877_abnormal_DNA_methylation2.24622145
7MP0008058_abnormal_DNA_repair2.08477668
8MP0006072_abnormal_retinal_apoptosis2.01469396
9MP0005410_abnormal_fertilization1.99367693
10MP0002837_dystrophic_cardiac_calcinosis1.97218765
11MP0002102_abnormal_ear_morphology1.97088636
12MP0003718_maternal_effect1.95541810
13MP0005646_abnormal_pituitary_gland1.94992242
14MP0003195_calcinosis1.85368734
15MP0009697_abnormal_copulation1.83584063
16MP0002938_white_spotting1.80551358
17MP0000569_abnormal_digit_pigmentation1.77832167
18MP0001968_abnormal_touch/_nociception1.77059274
19MP0008875_abnormal_xenobiotic_pharmacok1.76684445
20MP0003136_yellow_coat_color1.75940070
21MP0001984_abnormal_olfaction1.75792777
22MP0002736_abnormal_nociception_after1.74985618
23MP0010094_abnormal_chromosome_stability1.71747932
24MP0005253_abnormal_eye_physiology1.67393814
25MP0009379_abnormal_foot_pigmentation1.66911433
26MP0003315_abnormal_perineum_morphology1.61646917
27MP0000631_abnormal_neuroendocrine_gland1.60311526
28MP0003693_abnormal_embryo_hatching1.60176566
29MP0005551_abnormal_eye_electrophysiolog1.59259829
30MP0005174_abnormal_tail_pigmentation1.59068811
31MP0002277_abnormal_respiratory_mucosa1.57822282
32MP0008789_abnormal_olfactory_epithelium1.55996530
33MP0008872_abnormal_physiological_respon1.53695327
34MP0002160_abnormal_reproductive_system1.53478037
35MP0004142_abnormal_muscle_tone1.45692712
36MP0006035_abnormal_mitochondrial_morpho1.45530111
37MP0006036_abnormal_mitochondrial_physio1.45291022
38MP0001929_abnormal_gametogenesis1.44359936
39MP0006276_abnormal_autonomic_nervous1.42790528
40MP0003186_abnormal_redox_activity1.42180984
41MP0004133_heterotaxia1.42081785
42MP0002653_abnormal_ependyma_morphology1.41457261
43MP0002638_abnormal_pupillary_reflex1.40262599
44MP0008057_abnormal_DNA_replication1.36923126
45MP0005084_abnormal_gallbladder_morpholo1.35901999
46MP0002210_abnormal_sex_determination1.35277882
47MP0002132_abnormal_respiratory_system1.33168561
48MP0005394_taste/olfaction_phenotype1.30661152
49MP0005499_abnormal_olfactory_system1.30661152
50MP0003567_abnormal_fetal_cardiomyocyte1.29933215
51MP0001485_abnormal_pinna_reflex1.28884735
52MP0009046_muscle_twitch1.28617596
53MP0003698_abnormal_male_reproductive1.27121303
54MP0001905_abnormal_dopamine_level1.25488364
55MP0009745_abnormal_behavioral_response1.24242919
56MP0008995_early_reproductive_senescence1.21208736
57MP0005645_abnormal_hypothalamus_physiol1.15821396
58MP0008007_abnormal_cellular_replicative1.14295612
59MP0001293_anophthalmia1.13924213
60MP0000372_irregular_coat_pigmentation1.11722905
61MP0005389_reproductive_system_phenotype1.11175780
62MP0001145_abnormal_male_reproductive1.10255716
63MP0000653_abnormal_sex_gland1.09956972
64MP0001919_abnormal_reproductive_system1.05004341
65MP0002272_abnormal_nervous_system1.03738182
66MP0002095_abnormal_skin_pigmentation1.00856381
67MP0003937_abnormal_limbs/digits/tail_de0.98977865
68MP0000566_synostosis0.98828455
69MP0005332_abnormal_amino_acid0.97812823
70MP0003011_delayed_dark_adaptation0.97110393
71MP0002751_abnormal_autonomic_nervous0.97100064
72MP0003121_genomic_imprinting0.97091598
73MP0000049_abnormal_middle_ear0.95726286
74MP0005365_abnormal_bile_salt0.94308842
75MP0003122_maternal_imprinting0.92527316
76MP0003077_abnormal_cell_cycle0.92012727
77MP0003786_premature_aging0.91308425
78MP0001188_hyperpigmentation0.91235798
79MP0004145_abnormal_muscle_electrophysio0.91080342
80MP0002557_abnormal_social/conspecific_i0.85300390
81MP0005085_abnormal_gallbladder_physiolo0.83371482
82MP0005391_vision/eye_phenotype0.82351861
83MP0003938_abnormal_ear_development0.81769559
84MP0002163_abnormal_gland_morphology0.81180394
85MP0001986_abnormal_taste_sensitivity0.81032002
86MP0003787_abnormal_imprinting0.80926394
87MP0005266_abnormal_metabolism0.80881906
88MP0003252_abnormal_bile_duct0.80603213
89MP0005195_abnormal_posterior_eye0.74807288
90MP0002233_abnormal_nose_morphology0.74077476
91MP0002184_abnormal_innervation0.72273255
92MP0004957_abnormal_blastocyst_morpholog0.72220685
93MP0002752_abnormal_somatic_nervous0.72042764
94MP0004134_abnormal_chest_morphology0.71382077
95MP0000647_abnormal_sebaceous_gland0.71019351
96MP0003119_abnormal_digestive_system0.70949370
97MP0002067_abnormal_sensory_capabilities0.70519926
98MP0003111_abnormal_nucleus_morphology0.70215669
99MP0000026_abnormal_inner_ear0.70106780
100MP0000427_abnormal_hair_cycle0.69849144

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.33450444
2Acute encephalopathy (HP:0006846)3.93555694
3Abnormal mitochondria in muscle tissue (HP:0008316)3.88122445
4Mitochondrial inheritance (HP:0001427)3.80333242
5Pancreatic cysts (HP:0001737)3.58794268
6Progressive macrocephaly (HP:0004481)3.55590029
73-Methylglutaconic aciduria (HP:0003535)3.47341930
8Hepatocellular necrosis (HP:0001404)3.37317463
9Increased CSF lactate (HP:0002490)3.36149963
10Abnormality of midbrain morphology (HP:0002418)3.23427078
11Molar tooth sign on MRI (HP:0002419)3.23427078
12Pancreatic fibrosis (HP:0100732)3.23173406
13Reduced antithrombin III activity (HP:0001976)3.16794211
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.16470048
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.16470048
16True hermaphroditism (HP:0010459)3.12575957
17Type I transferrin isoform profile (HP:0003642)3.12337096
18Hepatic necrosis (HP:0002605)3.10999856
19Abnormal protein glycosylation (HP:0012346)3.10247399
20Abnormal glycosylation (HP:0012345)3.10247399
21Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.10247399
22Abnormal protein N-linked glycosylation (HP:0012347)3.10247399
23Lipid accumulation in hepatocytes (HP:0006561)3.01698692
24Nephronophthisis (HP:0000090)2.84620583
25Cerebral edema (HP:0002181)2.82806927
26Methylmalonic acidemia (HP:0002912)2.80887070
27Increased hepatocellular lipid droplets (HP:0006565)2.73268372
28Hyperglycinemia (HP:0002154)2.71880493
29Meckel diverticulum (HP:0002245)2.62901702
30Intestinal atresia (HP:0011100)2.60804160
31Aplasia/hypoplasia of the uterus (HP:0008684)2.59361049
32Type II lissencephaly (HP:0007260)2.59004008
33Colon cancer (HP:0003003)2.58055709
34Abnormality of the ileum (HP:0001549)2.56397594
35Increased serum lactate (HP:0002151)2.53372163
36Abnormal biliary tract physiology (HP:0012439)2.46365953
37Bile duct proliferation (HP:0001408)2.46365953
38Methylmalonic aciduria (HP:0012120)2.45652369
39Lactic acidosis (HP:0003128)2.42738336
40Abnormality of the renal medulla (HP:0100957)2.42229435
41Abnormal number of erythroid precursors (HP:0012131)2.39450235
42Renal Fanconi syndrome (HP:0001994)2.39261889
43Congenital stationary night blindness (HP:0007642)2.36686465
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.36605597
45Medial flaring of the eyebrow (HP:0010747)2.34072738
46Hyperglycinuria (HP:0003108)2.33476648
47Absent thumb (HP:0009777)2.32807064
48Abnormality of the renal cortex (HP:0011035)2.29329845
49Renal cortical cysts (HP:0000803)2.27592612
50Cerebellar dysplasia (HP:0007033)2.26588962
51Optic disc pallor (HP:0000543)2.23929802
52Abnormality of methionine metabolism (HP:0010901)2.21465856
53Chronic hepatic failure (HP:0100626)2.20746779
54Pendular nystagmus (HP:0012043)2.19308827
55Dynein arm defect of respiratory motile cilia (HP:0012255)2.17470140
56Absent/shortened dynein arms (HP:0200106)2.17470140
57Reticulocytopenia (HP:0001896)2.15584779
58Abnormality of serine family amino acid metabolism (HP:0010894)2.15006287
59Abnormality of glycine metabolism (HP:0010895)2.15006287
60Gastrointestinal atresia (HP:0002589)2.14300923
61Hypothermia (HP:0002045)2.13940589
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10837393
63Abnormality of alanine metabolism (HP:0010916)2.10837393
64Hyperalaninemia (HP:0003348)2.10837393
65Male pseudohermaphroditism (HP:0000037)2.10804291
66Lethargy (HP:0001254)2.10208854
67Congenital, generalized hypertrichosis (HP:0004540)2.08398602
68Abnormality of aspartate family amino acid metabolism (HP:0010899)2.07286793
69Abnormality of cells of the erythroid lineage (HP:0012130)2.07231222
70Macrocytic anemia (HP:0001972)2.06684036
71Increased intramyocellular lipid droplets (HP:0012240)2.05672403
72Respiratory failure (HP:0002878)2.04807897
73Cystic liver disease (HP:0006706)2.04195933
74Hypoplasia of the pons (HP:0012110)2.01968106
75Abnormality of the preputium (HP:0100587)1.99516341
76Abnormal ciliary motility (HP:0012262)1.99469258
77Abnormal respiratory motile cilium morphology (HP:0005938)1.98550270
78Abnormal respiratory epithelium morphology (HP:0012253)1.98550270
79Abolished electroretinogram (ERG) (HP:0000550)1.97761852
80Tubulointerstitial nephritis (HP:0001970)1.97223107
81Short tibia (HP:0005736)1.96933508
82Exertional dyspnea (HP:0002875)1.95075084
83Abnormality of serum amino acid levels (HP:0003112)1.94975163
84Hypoplasia of the uterus (HP:0000013)1.94591287
85Aplasia/Hypoplasia of the tibia (HP:0005772)1.93565161
86Abnormality of DNA repair (HP:0003254)1.92775590
87Generalized aminoaciduria (HP:0002909)1.90683864
88Increased muscle lipid content (HP:0009058)1.90418408
89Abnormality of the pons (HP:0007361)1.89318369
90Congenital primary aphakia (HP:0007707)1.88830394
91Median cleft lip (HP:0000161)1.87211748
92Abnormality of the labia minora (HP:0012880)1.86876168
93Constricted visual fields (HP:0001133)1.85009664
94Exercise intolerance (HP:0003546)1.83265818
95Abnormal respiratory motile cilium physiology (HP:0012261)1.82233962
96Gait imbalance (HP:0002141)1.81864978
97Leukodystrophy (HP:0002415)1.81850506
98Abnormality of chromosome stability (HP:0003220)1.81281470
99Abnormality of the vitamin B12 metabolism (HP:0004341)1.80775731
100Abnormal rod and cone electroretinograms (HP:0008323)1.79167199

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.43077132
2ZAK3.33337476
3BMPR1B3.19758895
4PINK13.06271794
5STK162.89069590
6MAP4K22.77962538
7VRK22.64832817
8VRK12.51149103
9MST42.21073734
10WNK32.20808177
11TNIK2.01863983
12FRK2.01492677
13NUAK11.99902483
14ADRBK21.98166331
15TAF11.93020351
16BUB11.81057396
17TLK11.76162112
18INSRR1.74753434
19EIF2AK11.68678609
20MAP2K71.63134205
21SRPK11.52293583
22PBK1.50863959
23GRK11.48338411
24EIF2AK31.45550294
25BCKDK1.43165718
26PLK41.42088568
27PLK31.35812847
28MAPK131.33389457
29MARK31.33070744
30ACVR1B1.32752586
31MAP3K41.32499455
32DYRK21.25307049
33TNK21.24070930
34NME11.23912151
35MKNK21.18379305
36WEE11.17626884
37MUSK1.13133477
38CDC71.10982214
39STK38L1.09864663
40OXSR11.07685191
41PNCK1.03785663
42TRIM281.00113260
43WNK40.97653652
44BRSK20.97517643
45CDK190.97094101
46CDK30.95273952
47PLK20.94107833
48CSNK1G30.92979026
49GRK50.88571791
50TSSK60.88398503
51EPHA40.85265196
52NEK20.81884322
53MKNK10.80158737
54PLK10.79013286
55CSNK1G20.78481163
56STK390.76144216
57PASK0.74783562
58CSNK1G10.74746407
59MAPKAPK30.74589103
60PRKCG0.73832374
61MAPK150.70649507
62DYRK30.69467701
63IRAK20.69418677
64RPS6KA50.69079939
65TGFBR10.68242240
66NLK0.67488640
67CSNK1A1L0.65803032
68TXK0.64411003
69OBSCN0.62745082
70PRKCE0.59722430
71PRKCQ0.57352779
72ATR0.52232128
73CHEK20.50627583
74AURKB0.49640011
75ADRBK10.48381666
76CSNK2A10.44211641
77MYLK0.43659779
78PAK30.43287529
79TTK0.42446627
80RPS6KA40.40885320
81ATM0.40429397
82GRK60.39380670
83CSNK2A20.39034400
84STK40.38688287
85BCR0.36219754
86PHKG10.35633657
87PHKG20.35633657
88NME20.35471073
89CASK0.35083039
90CSNK1A10.34437035
91CCNB10.34064921
92CAMK10.33251856
93PTK2B0.32123804
94IKBKB0.31779214
95MAPKAPK50.31745873
96IRAK10.29892467
97TIE10.29820752
98DAPK10.29172301
99CSNK1E0.28331682
100AURKA0.27394165

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.63640219
2Ribosome_Homo sapiens_hsa030103.30627683
3Parkinsons disease_Homo sapiens_hsa050123.14458702
4RNA polymerase_Homo sapiens_hsa030203.06015709
5Proteasome_Homo sapiens_hsa030502.89285063
6Protein export_Homo sapiens_hsa030602.61127845
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.47681017
8Homologous recombination_Homo sapiens_hsa034402.27212628
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.21407954
10Huntingtons disease_Homo sapiens_hsa050162.14241229
11Alzheimers disease_Homo sapiens_hsa050102.05478648
12RNA degradation_Homo sapiens_hsa030181.95266246
13One carbon pool by folate_Homo sapiens_hsa006701.90630132
14Fanconi anemia pathway_Homo sapiens_hsa034601.90108101
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.88262070
16Basal transcription factors_Homo sapiens_hsa030221.85969124
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.81159938
18Propanoate metabolism_Homo sapiens_hsa006401.78028664
19DNA replication_Homo sapiens_hsa030301.73384347
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.66473945
21Mismatch repair_Homo sapiens_hsa034301.65255122
22Pyrimidine metabolism_Homo sapiens_hsa002401.65229170
23Butanoate metabolism_Homo sapiens_hsa006501.59845625
24Nucleotide excision repair_Homo sapiens_hsa034201.56140838
25Spliceosome_Homo sapiens_hsa030401.41652118
26Purine metabolism_Homo sapiens_hsa002301.39551105
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38688771
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36316960
29RNA transport_Homo sapiens_hsa030131.31802368
30Phototransduction_Homo sapiens_hsa047441.31577994
31Base excision repair_Homo sapiens_hsa034101.30687868
32Peroxisome_Homo sapiens_hsa041461.30124237
33Selenocompound metabolism_Homo sapiens_hsa004501.28152966
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.25574524
35Linoleic acid metabolism_Homo sapiens_hsa005911.23420923
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22992073
37Cardiac muscle contraction_Homo sapiens_hsa042601.22469171
38Nitrogen metabolism_Homo sapiens_hsa009101.17848236
39Chemical carcinogenesis_Homo sapiens_hsa052041.17640917
40Caffeine metabolism_Homo sapiens_hsa002321.17384775
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.14667055
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14622121
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12968304
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12125549
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.06695537
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02217543
47Folate biosynthesis_Homo sapiens_hsa007901.00639706
48Steroid biosynthesis_Homo sapiens_hsa001001.00395092
49Tryptophan metabolism_Homo sapiens_hsa003800.97530542
50Non-homologous end-joining_Homo sapiens_hsa034500.95035618
51Regulation of autophagy_Homo sapiens_hsa041400.94953914
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94930732
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94469349
54Metabolic pathways_Homo sapiens_hsa011000.94072069
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93865999
56Olfactory transduction_Homo sapiens_hsa047400.93309089
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91554260
58Sulfur metabolism_Homo sapiens_hsa009200.91059579
59Glutathione metabolism_Homo sapiens_hsa004800.87072699
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85899922
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.82592078
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80782924
63Retinol metabolism_Homo sapiens_hsa008300.80011599
64beta-Alanine metabolism_Homo sapiens_hsa004100.79175894
65Ether lipid metabolism_Homo sapiens_hsa005650.73926744
66Pyruvate metabolism_Homo sapiens_hsa006200.73535392
67Nicotine addiction_Homo sapiens_hsa050330.72902638
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.71957558
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71920578
70Mineral absorption_Homo sapiens_hsa049780.71665148
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70917729
72N-Glycan biosynthesis_Homo sapiens_hsa005100.69254693
73Arachidonic acid metabolism_Homo sapiens_hsa005900.68375799
74Fat digestion and absorption_Homo sapiens_hsa049750.61709612
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61491507
76Fatty acid degradation_Homo sapiens_hsa000710.55936323
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53326191
78Taste transduction_Homo sapiens_hsa047420.53050884
79Fatty acid elongation_Homo sapiens_hsa000620.52653172
80Systemic lupus erythematosus_Homo sapiens_hsa053220.52643323
81Hedgehog signaling pathway_Homo sapiens_hsa043400.48028489
82Vitamin digestion and absorption_Homo sapiens_hsa049770.47293159
83Sulfur relay system_Homo sapiens_hsa041220.47118532
84p53 signaling pathway_Homo sapiens_hsa041150.46302754
85Collecting duct acid secretion_Homo sapiens_hsa049660.45560763
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42198775
87Arginine and proline metabolism_Homo sapiens_hsa003300.40646170
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.40108554
89Oocyte meiosis_Homo sapiens_hsa041140.36609090
90mRNA surveillance pathway_Homo sapiens_hsa030150.36600951
91Primary immunodeficiency_Homo sapiens_hsa053400.36301379
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35069734
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34512451
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34373760
95Cell cycle_Homo sapiens_hsa041100.33961287
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25643063
97Glycerolipid metabolism_Homo sapiens_hsa005610.25248329
98Fatty acid metabolism_Homo sapiens_hsa012120.24106253
99Circadian rhythm_Homo sapiens_hsa047100.23555037
100Tyrosine metabolism_Homo sapiens_hsa003500.21000677

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »