SRP68

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)7.85902209
2COPI coating of Golgi vesicle (GO:0048205)7.85902209
3folic acid-containing compound biosynthetic process (GO:0009396)5.25365558
4mitotic chromosome condensation (GO:0007076)5.22101559
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.93929797
6DNA unwinding involved in DNA replication (GO:0006268)4.61453039
7protein retention in ER lumen (GO:0006621)4.52215039
8IMP biosynthetic process (GO:0006188)4.38380383
9positive regulation of nuclease activity (GO:0032075)4.38123289
10activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.36992784
11retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.29386865
12formation of translation preinitiation complex (GO:0001731)4.09129454
13nuclear pore complex assembly (GO:0051292)4.05051491
14regulation of nuclease activity (GO:0032069)4.04669626
15regulation of translational fidelity (GO:0006450)3.97566828
16mitotic sister chromatid segregation (GO:0000070)3.90461011
17IMP metabolic process (GO:0046040)3.87138974
18COPII vesicle coating (GO:0048208)3.82210655
19endoplasmic reticulum unfolded protein response (GO:0030968)3.76781198
20establishment of integrated proviral latency (GO:0075713)3.67852355
21nucleobase biosynthetic process (GO:0046112)3.63537105
22cellular response to unfolded protein (GO:0034620)3.61531662
23ribosomal small subunit assembly (GO:0000028)3.60039037
24peptidyl-arginine omega-N-methylation (GO:0035247)3.54905564
25regulation of mammary gland epithelial cell proliferation (GO:0033599)3.54049746
26mitotic metaphase plate congression (GO:0007080)3.51490091
27exocrine pancreas development (GO:0031017)3.51448070
284-hydroxyproline metabolic process (GO:0019471)3.49051413
29sister chromatid segregation (GO:0000819)3.48474685
30protein localization to kinetochore (GO:0034501)3.47411671
31nucleobase-containing small molecule interconversion (GO:0015949)3.46969043
32pteridine-containing compound biosynthetic process (GO:0042559)3.45644573
33DNA strand elongation involved in DNA replication (GO:0006271)3.43088801
34cellular response to topologically incorrect protein (GO:0035967)3.41869580
35ER-nucleus signaling pathway (GO:0006984)3.39131790
36regulation of translational termination (GO:0006449)3.35774024
37regulation of RNA export from nucleus (GO:0046831)3.33296756
38mitotic nuclear envelope disassembly (GO:0007077)3.31632558
39nuclear pore organization (GO:0006999)3.31373369
40ribosome biogenesis (GO:0042254)3.30681715
41ribosomal small subunit biogenesis (GO:0042274)3.29299842
42maternal placenta development (GO:0001893)3.26041438
43peptidyl-lysine dimethylation (GO:0018027)3.25559551
44protein maturation by protein folding (GO:0022417)3.25506359
45mitotic nuclear envelope reassembly (GO:0007084)3.25410740
46nuclear envelope reassembly (GO:0031468)3.25410740
47* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.24443266
48DNA strand elongation (GO:0022616)3.21773569
49ribosome assembly (GO:0042255)3.21610331
50tetrahydrofolate metabolic process (GO:0046653)3.19562826
51negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.18887023
52* protein targeting to ER (GO:0045047)3.13825555
53regulation of nucleobase-containing compound transport (GO:0032239)3.13162873
54purine nucleobase biosynthetic process (GO:0009113)3.12156810
55vesicle coating (GO:0006901)3.10691684
56pore complex assembly (GO:0046931)3.08991056
57* cotranslational protein targeting to membrane (GO:0006613)3.08726362
58nuclear envelope disassembly (GO:0051081)3.08149868
59membrane disassembly (GO:0030397)3.08149868
60pentose-phosphate shunt (GO:0006098)3.05634995
61translational elongation (GO:0006414)3.04311752
62peptidyl-proline hydroxylation (GO:0019511)3.03742700
63chromosome condensation (GO:0030261)3.03700952
64ribonucleoprotein complex biogenesis (GO:0022613)3.01804845
65establishment of viral latency (GO:0019043)3.00538041
66* establishment of protein localization to endoplasmic reticulum (GO:0072599)3.00192383
67viral transcription (GO:0019083)2.98148842
68translational termination (GO:0006415)2.96942227
69protein hydroxylation (GO:0018126)2.95215854
70protein complex localization (GO:0031503)2.93688463
71valine metabolic process (GO:0006573)2.93071031
72* protein localization to endoplasmic reticulum (GO:0070972)2.91158762
73response to endoplasmic reticulum stress (GO:0034976)2.89485778
74L-serine metabolic process (GO:0006563)2.88910892
75translational initiation (GO:0006413)2.86990692
76histone arginine methylation (GO:0034969)2.86433348
77negative regulation of mRNA metabolic process (GO:1903312)2.85521508
78negative regulation of RNA splicing (GO:0033119)2.84216274
79peptidyl-arginine methylation (GO:0018216)2.82215702
80peptidyl-arginine N-methylation (GO:0035246)2.82215702
81response to unfolded protein (GO:0006986)2.81238859
82ncRNA 3-end processing (GO:0043628)2.78781575
83proline metabolic process (GO:0006560)2.77988659
84histone H2B ubiquitination (GO:0033523)2.76063662
85DNA duplex unwinding (GO:0032508)2.75285842
86folic acid metabolic process (GO:0046655)2.74458777
87translesion synthesis (GO:0019985)2.73977218
88activation of Rac GTPase activity (GO:0032863)2.73823228
89viral mRNA export from host cell nucleus (GO:0046784)2.73406767
90DNA geometric change (GO:0032392)2.72846040
91maturation of SSU-rRNA (GO:0030490)2.72796842
92tRNA aminoacylation for protein translation (GO:0006418)2.69846601
93oxaloacetate metabolic process (GO:0006107)2.69189674
94L-alpha-amino acid transmembrane transport (GO:1902475)2.69088777
95regulation of mitotic spindle organization (GO:0060236)2.68764163
963-UTR-mediated mRNA stabilization (GO:0070935)2.68748665
97telomere maintenance via semi-conservative replication (GO:0032201)2.68732846
98deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.68539822
99negative regulation of mRNA processing (GO:0050686)2.68508818
100DNA replication initiation (GO:0006270)2.68432426
101response to topologically incorrect protein (GO:0035966)2.67900037
102protein export from nucleus (GO:0006611)2.67746459
103spliceosomal tri-snRNP complex assembly (GO:0000244)2.67433458
104cellular protein complex localization (GO:0034629)2.67159523
105glucocorticoid receptor signaling pathway (GO:0042921)2.66760112
106protein localization to chromosome, centromeric region (GO:0071459)2.66508716
107positive regulation of DNA-templated transcription, elongation (GO:0032786)2.63365879
108nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.63232816
109mRNA splicing, via spliceosome (GO:0000398)2.63142285
110RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.63142285
111proline biosynthetic process (GO:0006561)2.63034276
112histone-serine phosphorylation (GO:0035404)2.62630815
113amino acid activation (GO:0043038)2.61619055
114tRNA aminoacylation (GO:0043039)2.61619055
115glucose catabolic process (GO:0006007)2.61537150
116nucleosome disassembly (GO:0006337)2.61433630
117protein-DNA complex disassembly (GO:0032986)2.61433630
118heterochromatin organization (GO:0070828)2.59595126
119positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.58283767
120folic acid-containing compound metabolic process (GO:0006760)2.58043167
121peptidyl-asparagine modification (GO:0018196)2.57813528
122T cell apoptotic process (GO:0070231)2.57201938
123glycolytic process (GO:0006096)2.56743099
124nuclear envelope organization (GO:0006998)2.56704457
125regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.56059343
126deoxyribonucleotide biosynthetic process (GO:0009263)2.55512016
127protein N-linked glycosylation via asparagine (GO:0018279)2.55412600
128NADPH regeneration (GO:0006740)2.54379458
129serine family amino acid biosynthetic process (GO:0009070)2.54347770
130RNA splicing, via transesterification reactions (GO:0000375)2.53697313
131G1 DNA damage checkpoint (GO:0044783)2.53622712
132anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.53144111
133regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.51574894
134dosage compensation (GO:0007549)2.51437610
135tricarboxylic acid metabolic process (GO:0072350)2.51302636
136antigen processing and presentation via MHC class Ib (GO:0002475)2.51166284
137positive regulation of chromosome segregation (GO:0051984)2.51145578
138metaphase plate congression (GO:0051310)2.51087262
139mitotic G1 DNA damage checkpoint (GO:0031571)2.51054710
140UMP metabolic process (GO:0046049)2.50807517
141pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.50807517
142UMP biosynthetic process (GO:0006222)2.50807517
143pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.50807517
144mitotic G1/S transition checkpoint (GO:0044819)2.50728455
145regulation of mitochondrial translation (GO:0070129)2.49910672
146rRNA transcription (GO:0009303)2.49603106
147histone H2A monoubiquitination (GO:0035518)2.49202073
148regulation of translational elongation (GO:0006448)2.48714268
149negative regulation of cell size (GO:0045792)2.47834981
150peptide catabolic process (GO:0043171)2.47692293
151DNA topological change (GO:0006265)2.47549303
152pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.46781071
153protein localization to chromosome (GO:0034502)2.46702433
154ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.46376216
155pteridine-containing compound metabolic process (GO:0042558)2.45198105

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.16848587
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.89664612
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.19803791
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.96218764
5MYC_22102868_ChIP-Seq_BL_Human2.95720348
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.66102184
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.28066731
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.10207749
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10181722
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.06170413
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.03017320
12VDR_21846776_ChIP-Seq_THP-1_Human2.01178055
13E2F4_17652178_ChIP-ChIP_JURKAT_Human1.98926601
14ETS1_20019798_ChIP-Seq_JURKAT_Human1.98344340
15XRN2_22483619_ChIP-Seq_HELA_Human1.97817200
16CIITA_25753668_ChIP-Seq_RAJI_Human1.88438613
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.86752742
18EST1_17652178_ChIP-ChIP_JURKAT_Human1.84833223
19CREB1_15753290_ChIP-ChIP_HEK293T_Human1.78776347
20AR_21909140_ChIP-Seq_LNCAP_Human1.76086636
21NELFA_20434984_ChIP-Seq_ESCs_Mouse1.72874743
22ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72573195
23TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.70752901
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.70395028
25* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.69016075
26* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.67289234
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67151373
28ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.65510061
29GABP_19822575_ChIP-Seq_HepG2_Human1.61991264
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60887575
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.60669568
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.59908795
33CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.59678813
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.59631218
35KDM5A_27292631_Chip-Seq_BREAST_Human1.52129211
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.48578771
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44907101
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44593082
39FOXP3_21729870_ChIP-Seq_TREG_Human1.44389417
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42573734
41* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41998392
42VDR_23849224_ChIP-Seq_CD4+_Human1.41657545
43SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41623107
44CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.41208095
45DCP1A_22483619_ChIP-Seq_HELA_Human1.39352998
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38375202
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37751736
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.33777370
49TFEB_21752829_ChIP-Seq_HELA_Human1.30641647
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.28903224
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28036490
52KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24775888
53TCF7_22412390_ChIP-Seq_EML_Mouse1.24382709
54CLOCK_20551151_ChIP-Seq_293T_Human1.23966648
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23758293
56CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.23383481
57UTX_26944678_Chip-Seq_JUKART_Human1.23371445
58PPARA_22158963_ChIP-Seq_LIVER_Mouse1.23289856
59ATF3_27146783_Chip-Seq_COLON_Human1.23183361
60* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22761626
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.22167609
62TP63_17297297_ChIP-ChIP_HaCaT_Human1.21915888
63CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21858180
64TTF2_22483619_ChIP-Seq_HELA_Human1.21698658
65* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19909417
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19291571
67DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19181604
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18471819
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17832857
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17652561
71PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.17166367
72LXR_22292898_ChIP-Seq_THP-1_Human1.15810323
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15034706
74TET1_21451524_ChIP-Seq_MESCs_Mouse1.13960207
75POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12707992
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12707042
77GATA1_22025678_ChIP-Seq_K562_Human1.12398836
78SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.12192180
79TBX5_21415370_ChIP-Seq_HL-1_Mouse1.12138207
80SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12079509
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10850730
82HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10807854
83MAF_26560356_Chip-Seq_TH1_Human1.10531196
84MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.10326431
85RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10151509
86TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09850391
87* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08811474
88* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07967299
89PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07343360
90ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07163141
91CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.07144849
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06971732
93GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06398447
94TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06058607
95VDR_24763502_ChIP-Seq_THP-1_Human1.04829450
96TP53_22127205_ChIP-Seq_IMR90_Human1.04807710
97NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04682821
98THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04414714
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03321210
100CHD1_26751641_Chip-Seq_LNCaP_Human1.02843536
101BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01526441
102ZNF263_19887448_ChIP-Seq_K562_Human1.00957609
103RACK7_27058665_Chip-Seq_MCF-7_Human1.00882484
104POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00520836
105HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00248550
106* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00039015
107SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00020884
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99913387
109KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99424345
110TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99254101
111E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99020774
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98949802
113NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98753462
114* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98469901
115MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96960341
116MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.96579144
117CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95213888
118TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.94520375
119NANOG_21062744_ChIP-ChIP_HESCs_Human0.94078472
120NCOR1_26117541_ChIP-Seq_K562_Human0.93970093
121ELF1_20517297_ChIP-Seq_JURKAT_Human0.93944408
122MYB_26560356_Chip-Seq_TH2_Human0.93463267
123CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92865849

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.16798285
2MP0005451_abnormal_body_composition2.70769362
3MP0006054_spinal_hemorrhage2.62356107
4MP0010234_abnormal_vibrissa_follicle2.61717208
5MP0003705_abnormal_hypodermis_morpholog2.58799749
6MP0004957_abnormal_blastocyst_morpholog2.55603009
7MP0010352_gastrointestinal_tract_polyps2.45677684
8MP0002396_abnormal_hematopoietic_system2.39615368
9MP0002877_abnormal_melanocyte_morpholog2.31009164
10MP0003111_abnormal_nucleus_morphology2.23289106
11MP0005501_abnormal_skin_physiology2.12908651
12MP0005220_abnormal_exocrine_pancreas2.11976486
13MP0003077_abnormal_cell_cycle2.06668830
14MP0004264_abnormal_extraembryonic_tissu2.06504948
15MP0004185_abnormal_adipocyte_glucose2.05875702
16MP0005083_abnormal_biliary_tract2.05358838
17MP0010094_abnormal_chromosome_stability2.04586332
18MP0008260_abnormal_autophagy1.96733510
19MP0003806_abnormal_nucleotide_metabolis1.96374162
20MP0005623_abnormal_meninges_morphology1.89564290
21MP0003566_abnormal_cell_adhesion1.88949990
22MP0002796_impaired_skin_barrier1.87857130
23MP0000678_abnormal_parathyroid_gland1.84783705
24MP0004858_abnormal_nervous_system1.82228746
25MP0003300_gastrointestinal_ulcer1.79796024
26MP0005365_abnormal_bile_salt1.74131826
27MP0005076_abnormal_cell_differentiation1.68128128
28MP0001730_embryonic_growth_arrest1.66051191
29MP0008007_abnormal_cellular_replicative1.65672901
30MP0001666_abnormal_nutrient_absorption1.59612424
31MP0009840_abnormal_foam_cell1.58863270
32MP0001849_ear_inflammation1.56553869
33MP0000751_myopathy1.54818271
34MP0003283_abnormal_digestive_organ1.53071183
35MP0001346_abnormal_lacrimal_gland1.40471162
36MP0001348_abnormal_lacrimal_gland1.40215188
37MP0000350_abnormal_cell_proliferation1.37802404
38MP0001944_abnormal_pancreas_morphology1.36670922
39MP0003123_paternal_imprinting1.36642383
40MP0004233_abnormal_muscle_weight1.36502790
41MP0005058_abnormal_lysosome_morphology1.36184571
42MP0002693_abnormal_pancreas_physiology1.35191697
43MP0003453_abnormal_keratinocyte_physiol1.34007193
44MP0001727_abnormal_embryo_implantation1.32362508
45MP0000490_abnormal_crypts_of1.30775472
46MP0005257_abnormal_intraocular_pressure1.29808973
47MP0004808_abnormal_hematopoietic_stem1.29262623
48MP0004197_abnormal_fetal_growth/weight/1.28306995
49MP0002080_prenatal_lethality1.27419598
50MP0002269_muscular_atrophy1.26507111
51MP0003315_abnormal_perineum_morphology1.25552791
52MP0000537_abnormal_urethra_morphology1.25346967
53MP0003984_embryonic_growth_retardation1.24684463
54MP0002088_abnormal_embryonic_growth/wei1.22252533
55MP0000759_abnormal_skeletal_muscle1.21799584
56MP0009672_abnormal_birth_weight1.21683953
57MP0003763_abnormal_thymus_physiology1.20723010
58MP0001672_abnormal_embryogenesis/_devel1.20056475
59MP0005380_embryogenesis_phenotype1.20056475
60MP0001697_abnormal_embryo_size1.19393171
61MP0000858_altered_metastatic_potential1.19157307
62MP0002060_abnormal_skin_morphology1.17667213
63MP0010030_abnormal_orbit_morphology1.16639102
64MP0002163_abnormal_gland_morphology1.15945528
65MP0009333_abnormal_splenocyte_physiolog1.15570133
66MP0010307_abnormal_tumor_latency1.15485837
67MP0003786_premature_aging1.14214441
68MP0005023_abnormal_wound_healing1.11763848
69MP0001216_abnormal_epidermal_layer1.09625912
70MP0003941_abnormal_skin_development1.09356473
71MP0006035_abnormal_mitochondrial_morpho1.07804317
72MP0002086_abnormal_extraembryonic_tissu1.07229915
73MP0003221_abnormal_cardiomyocyte_apopto1.06925271
74MP0002019_abnormal_tumor_incidence1.04971414
75MP0003567_abnormal_fetal_cardiomyocyte1.04390342
76MP0009053_abnormal_anal_canal1.03741543
77MP0000703_abnormal_thymus_morphology1.02418186
78MP0002139_abnormal_hepatobiliary_system1.01330856
79MP0008961_abnormal_basal_metabolism1.01272556
80MP0003172_abnormal_lysosome_physiology1.01092299
81MP0000627_abnormal_mammary_gland1.00867727
82MP0004084_abnormal_cardiac_muscle1.00737117
83MP0000566_synostosis0.99127032
84MP0002084_abnormal_developmental_patter0.98964038
85MP0000003_abnormal_adipose_tissue0.98891334
86MP0000762_abnormal_tongue_morphology0.98317692
87MP0001881_abnormal_mammary_gland0.97498467
88MP0002085_abnormal_embryonic_tissue0.96776660
89MP0009643_abnormal_urine_homeostasis0.96710044
90MP0000733_abnormal_muscle_development0.95771004
91MP0008057_abnormal_DNA_replication0.93737698
92MP0000358_abnormal_cell_content/0.92808977
93MP0000313_abnormal_cell_death0.91810258
94MP0008438_abnormal_cutaneous_collagen0.91557362
95MP0000013_abnormal_adipose_tissue0.91348737
96MP0000747_muscle_weakness0.91193799
97MP0000750_abnormal_muscle_regeneration0.91162351
98MP0000598_abnormal_liver_morphology0.89943176
99MP0003942_abnormal_urinary_system0.89682698
100MP0002089_abnormal_postnatal_growth/wei0.89328271
101MP0005330_cardiomyopathy0.89246667
102MP0008058_abnormal_DNA_repair0.87785504
103MP0005319_abnormal_enzyme/_coenzyme0.87443365
104MP0004782_abnormal_surfactant_physiolog0.87431370
105MP0005394_taste/olfaction_phenotype0.86751132
106MP0005499_abnormal_olfactory_system0.86751132
107MP0000749_muscle_degeneration0.85969543
108MP0000428_abnormal_craniofacial_morphol0.85762891
109MP0002909_abnormal_adrenal_gland0.85256972
110MP0004087_abnormal_muscle_fiber0.85094606
111MP0002697_abnormal_eye_size0.84321203
112MP0008789_abnormal_olfactory_epithelium0.84320089
113MP0008932_abnormal_embryonic_tissue0.83508327
114MP0010630_abnormal_cardiac_muscle0.81597839
115MP0003279_aneurysm0.81066975
116MP0005666_abnormal_adipose_tissue0.79789159
117MP0002722_abnormal_immune_system0.79273053
118MP0001873_stomach_inflammation0.78768433
119MP0003252_abnormal_bile_duct0.78547458
120MP0002249_abnormal_larynx_morphology0.78394194
121MP0002098_abnormal_vibrissa_morphology0.78311914
122MP0000609_abnormal_liver_physiology0.77414096
123MP0002092_abnormal_eye_morphology0.77362150
124MP0002398_abnormal_bone_marrow0.77037297
125MP0003329_amyloid_beta_deposits0.76793655
126MP0009278_abnormal_bone_marrow0.75344036
127MP0002970_abnormal_white_adipose0.75313116
128MP0000467_abnormal_esophagus_morphology0.75274592
129MP0003091_abnormal_cell_migration0.73507960
130MP0002078_abnormal_glucose_homeostasis0.72211913
131MP0002896_abnormal_bone_mineralization0.72088786
132MP0005384_cellular_phenotype0.71406906
133MP0005621_abnormal_cell_physiology0.70736505
134MP0005397_hematopoietic_system_phenotyp0.70710191
135MP0001545_abnormal_hematopoietic_system0.70710191
136MP0001915_intracranial_hemorrhage0.70393815
137MP0003115_abnormal_respiratory_system0.70100755
138MP0006036_abnormal_mitochondrial_physio0.68554905
139MP0000477_abnormal_intestine_morphology0.68351869
140MP0005375_adipose_tissue_phenotype0.67373193
141MP0000689_abnormal_spleen_morphology0.66272063
142MP0000266_abnormal_heart_morphology0.65269027

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)3.57276061
2Abnormal gallbladder physiology (HP:0012438)3.31688731
3Cholecystitis (HP:0001082)3.31688731
4Microvesicular hepatic steatosis (HP:0001414)3.25558455
5Thrombocytosis (HP:0001894)3.22704410
6Insomnia (HP:0100785)3.05284957
7Ragged-red muscle fibers (HP:0003200)2.98405876
8Abnormality of the pancreatic islet cells (HP:0006476)2.96787463
9Abnormality of endocrine pancreas physiology (HP:0012093)2.96787463
10Abnormality of the calcaneus (HP:0008364)2.95171584
11Late onset (HP:0003584)2.89059303
12Achilles tendon contracture (HP:0001771)2.89002137
13Back pain (HP:0003418)2.80253514
14Abnormality of glycolysis (HP:0004366)2.77462509
15Hypoglycemic seizures (HP:0002173)2.76077053
16Ulnar deviation of the wrist (HP:0003049)2.75497697
17Cervical subluxation (HP:0003308)2.71323103
18Premature rupture of membranes (HP:0001788)2.65498478
19Ependymoma (HP:0002888)2.62528996
20Unilateral renal agenesis (HP:0000122)2.62384643
21Abnormality of the Achilles tendon (HP:0005109)2.55059902
22Vertebral compression fractures (HP:0002953)2.51122520
23Hyperinsulinemic hypoglycemia (HP:0000825)2.50054375
24Protrusio acetabuli (HP:0003179)2.46812389
25Hyperacusis (HP:0010780)2.44338378
26Severe short stature (HP:0003510)2.41787620
27Entropion (HP:0000621)2.41323675
28Long palpebral fissure (HP:0000637)2.38793770
29Hand muscle atrophy (HP:0009130)2.36615080
30Myoglobinuria (HP:0002913)2.35618132
31Increased serum pyruvate (HP:0003542)2.34600069
32Diaphragmatic weakness (HP:0009113)2.29078563
33Squamous cell carcinoma (HP:0002860)2.28295266
34Spinal rigidity (HP:0003306)2.27310773
35Calcaneovalgus deformity (HP:0001848)2.27272735
36Deformed tarsal bones (HP:0008119)2.27255324
37Orthostatic hypotension (HP:0001278)2.26396812
38Abnormality of the intrinsic pathway (HP:0010989)2.26379592
39Abnormality of the anterior horn cell (HP:0006802)2.25750676
40Degeneration of anterior horn cells (HP:0002398)2.25750676
41Pancreatic islet-cell hyperplasia (HP:0004510)2.23565072
42Progressive external ophthalmoplegia (HP:0000590)2.22079931
43Dysostosis multiplex (HP:0000943)2.21711563
44Progressive muscle weakness (HP:0003323)2.20149522
45Reticulocytosis (HP:0001923)2.19227531
46Urinary glycosaminoglycan excretion (HP:0003541)2.19077679
47Mucopolysacchariduria (HP:0008155)2.19077679
48Myopathic facies (HP:0002058)2.15779457
49Abnormality of cells of the erythroid lineage (HP:0012130)2.14399756
50Ketoacidosis (HP:0001993)2.14316046
51Vertebral arch anomaly (HP:0008438)2.13795996
52Trismus (HP:0000211)2.12124969
53Distal lower limb amyotrophy (HP:0008944)2.10722996
54Exercise-induced muscle cramps (HP:0003710)2.10442717
55Abnormal number of erythroid precursors (HP:0012131)2.08701267
56Secondary amenorrhea (HP:0000869)2.07824812
57Abnormal tarsal ossification (HP:0008369)2.05662167
58Nonimmune hydrops fetalis (HP:0001790)2.04364591
59Rhabdomyolysis (HP:0003201)2.04150004
60Insulin resistance (HP:0000855)2.04077250
61Generalized aminoaciduria (HP:0002909)2.02438270
62Metaphyseal cupping (HP:0003021)2.02029158
63Upper limb amyotrophy (HP:0009129)2.02011995
64Distal upper limb amyotrophy (HP:0007149)2.02011995
65Hyperparathyroidism (HP:0000843)2.01920797
66Abnormality of subcutaneous fat tissue (HP:0001001)1.98372542
67Ankle contracture (HP:0006466)1.98030270
68Pseudobulbar signs (HP:0002200)1.97797762
69Abnormality of the distal phalanges of the toes (HP:0010182)1.97379705
70Adenoma sebaceum (HP:0009720)1.97150389
71Angiofibromas (HP:0010615)1.97150389
72Cholelithiasis (HP:0001081)1.96109170
73Chromosomal breakage induced by crosslinking agents (HP:0003221)1.95373312
74Abnormality of reticulocytes (HP:0004312)1.94207873
75Type 1 muscle fiber predominance (HP:0003803)1.93945468
76Asymmetric septal hypertrophy (HP:0001670)1.93827352
77Multiple enchondromatosis (HP:0005701)1.93599198
78Deviation of the thumb (HP:0009603)1.92290581
79Patellar dislocation (HP:0002999)1.92238268
80Athetosis (HP:0002305)1.91300024
81Carpal bone hypoplasia (HP:0001498)1.91207331
82Reticulocytopenia (HP:0001896)1.90468143
83Hypercortisolism (HP:0001578)1.90408023
84Limb-girdle muscle atrophy (HP:0003797)1.89697960
85Poikiloderma (HP:0001029)1.88597375
86Cerebral aneurysm (HP:0004944)1.86668326
87Ulnar bowing (HP:0003031)1.86583687
88Hypoplasia of the pons (HP:0012110)1.86577619
89Limb hypertonia (HP:0002509)1.86499137
90Fasciculations (HP:0002380)1.86203223
91Abnormality of carpal bone ossification (HP:0006257)1.85885423
92Joint stiffness (HP:0001387)1.85339442
93Septate vagina (HP:0001153)1.85263950
94Abnormality of mucopolysaccharide metabolism (HP:0011020)1.84636313
95Abnormality of polysaccharide metabolism (HP:0011012)1.84636313
96Abnormality of glycosaminoglycan metabolism (HP:0004371)1.84636313
97Rectal prolapse (HP:0002035)1.84289313
98Hyperglycemia (HP:0003074)1.84143545
99High pitched voice (HP:0001620)1.83543261
100Missing ribs (HP:0000921)1.83267696
101Rough bone trabeculation (HP:0100670)1.82757229
102Short nail (HP:0001799)1.81377112
103Selective tooth agenesis (HP:0001592)1.80876193
104Increased nuchal translucency (HP:0010880)1.79907454
105Glossoptosis (HP:0000162)1.79397444
106Abnormality of the acetabulum (HP:0003170)1.78847833
107Gout (HP:0001997)1.78229153
108Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78209190
10911 pairs of ribs (HP:0000878)1.77350550
110Symptomatic seizures (HP:0011145)1.77273226
111Sparse lateral eyebrow (HP:0005338)1.77082468
112Exercise-induced myalgia (HP:0003738)1.77031647
113Abnormality of the thoracic spine (HP:0100711)1.76442471
114Large for gestational age (HP:0001520)1.75901579
115Abnormality of the umbilical cord (HP:0010881)1.74756746
116Muscle stiffness (HP:0003552)1.74286851
117Microretrognathia (HP:0000308)1.73004944
118Ketosis (HP:0001946)1.72650861
119Chromsome breakage (HP:0040012)1.72549397
120Prominent metopic ridge (HP:0005487)1.72452658
121Proximal placement of thumb (HP:0009623)1.71294297
122Abnormal protein glycosylation (HP:0012346)1.71106109
123Abnormal glycosylation (HP:0012345)1.71106109
124Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71106109
125Abnormal protein N-linked glycosylation (HP:0012347)1.71106109
126Elbow flexion contracture (HP:0002987)1.71103144
127Thoracic kyphosis (HP:0002942)1.70955017
128Cortical dysplasia (HP:0002539)1.70669506
129Distal lower limb muscle weakness (HP:0009053)1.70321260
130Abnormal foot bone ossification (HP:0010675)1.69945603
131Overlapping toe (HP:0001845)1.69791337
132Increased connective tissue (HP:0009025)1.68739142
133Colon cancer (HP:0003003)1.67837669
134Centrally nucleated skeletal muscle fibers (HP:0003687)1.67507436
135Mildly elevated creatine phosphokinase (HP:0008180)1.67351314
136Shoulder girdle muscle weakness (HP:0003547)1.66795738
137Disproportionate tall stature (HP:0001519)1.66568347
138Testicular atrophy (HP:0000029)1.66357837
139Dysmetric saccades (HP:0000641)1.66183685
140Premature ovarian failure (HP:0008209)1.65858015
141Right ventricular cardiomyopathy (HP:0011663)1.65703209
142Abnormality of the gallbladder (HP:0005264)1.65110512
143Slender long bone (HP:0003100)1.64652638
144Premature skin wrinkling (HP:0100678)1.64009861
145Bowel diverticulosis (HP:0005222)1.63983288
146Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.63944909
147Vertebral hypoplasia (HP:0008417)1.63811362
148Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.63811362
149Generalized amyotrophy (HP:0003700)1.63731272
150Renal duplication (HP:0000075)1.63689434
151Flat acetabular roof (HP:0003180)1.63578688
152Aplastic anemia (HP:0001915)1.63570377
153Deep palmar crease (HP:0006191)1.62812600
154Abnormal ossification of hand bones (HP:0005921)1.62406639
155Abnormality of oral frenula (HP:0000190)1.60753836
156Aneurysm (HP:0002617)1.60361797
157Overriding aorta (HP:0002623)1.60132367
158Broad distal phalanx of finger (HP:0009836)1.59997627
159Abnormality of fatty-acid metabolism (HP:0004359)1.59536294
160Small epiphyses (HP:0010585)1.59398784
161Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.58765343
162Abnormal gallbladder morphology (HP:0012437)1.58698134
163Natal tooth (HP:0000695)1.58596203
164Spastic diplegia (HP:0001264)1.58141912
165Enlarged penis (HP:0000040)1.55182791
166Rhizomelia (HP:0008905)1.54593383
167Broad palm (HP:0001169)1.53953919
168Blepharitis (HP:0000498)1.53021502
169Abnormality of sulfur amino acid metabolism (HP:0004339)1.52711921
170Abnormality of the pons (HP:0007361)1.52337602
171B lymphocytopenia (HP:0010976)1.51748765

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.66817038
2PKN23.89524074
3TRIB33.64123098
4ERN13.10615320
5SMG13.05067506
6PASK2.99609115
7IRAK32.46700687
8SRPK12.35441676
9SIK12.27798817
10NEK12.21240253
11MAP3K102.20949055
12RPS6KB22.13767783
13BCKDK2.13282482
14SCYL22.12062848
15CDC72.06356356
16FLT31.97680071
17MAP2K31.88137785
18PAK41.78981557
19BUB11.72805794
20MAPKAPK31.70833880
21TSSK61.68493773
22VRK21.65707132
23NEK21.65628522
24MST1R1.65547463
25TAOK31.62340368
26NME11.62254897
27LATS21.60246772
28ARAF1.58388522
29TTN1.58082692
30EIF2AK31.52271642
31LRRK21.51417125
32PTK61.51280927
33EIF2AK11.46763603
34WEE11.42877272
35STK101.36850968
36ZAP701.28869680
37EPHA21.28631822
38PRPF4B1.24541915
39MAP3K31.23341003
40TESK21.20519072
41BRSK21.19897783
42RPS6KA41.19595402
43MAP4K11.19161027
44TESK11.18683939
45CDK121.18127070
46NTRK11.15060093
47MAP3K91.11738709
48MAP3K131.09864229
49PRKD31.09702668
50MAP3K81.04783817
51TGFBR11.02118893
52MTOR0.98774415
53BTK0.97549447
54TTK0.94287902
55NME20.93698800
56PBK0.91432297
57CDK70.91223052
58CDK40.89490924
59PAK20.88441104
60CHEK20.88172850
61ALK0.87718266
62KSR20.87190239
63DAPK10.85907816
64BRAF0.85322132
65ILK0.84323462
66TAOK20.83152942
67BMX0.82141251
68CAMK1D0.80928660
69ATR0.79907786
70PIK3CG0.78808097
71LATS10.76462081
72PIM20.76184964
73CDK11A0.75615473
74CDK90.75110673
75KDR0.74729511
76LIMK10.73928710
77TYRO30.71585723
78RIPK10.70697341
79PTK20.70673546
80CDK150.70250881
81MAP3K110.69079152
82MOS0.68588462
83BRD40.67914485
84CDK180.67473390
85SIK30.66971378
86AURKB0.66949236
87HIPK20.66312385
88CDK140.65959540
89BRSK10.64407707
90CAMK1G0.62364734
91STK160.62339340
92MAP3K140.61798950
93ITK0.61744642
94CHEK10.61524849
95PDGFRA0.59547907
96MAPK110.57495187
97CDK60.57255486
98CDK80.56740953
99PDK30.56565607
100PDK40.56565607
101RET0.55093110
102RAF10.54591329
103CDK10.54568273
104MET0.53198747
105PLK10.52622149
106ERBB40.51928737
107PRKCI0.51693180
108MAP2K20.51684230
109FGFR40.50708120
110CCNB10.50612306
111CSF1R0.47009620
112EPHB10.46277216
113TAOK10.45850998
114MAP3K70.43516149
115BCR0.43445551
116CDK20.41416749
117DMPK0.39993971
118CSNK1E0.39789133
119PAK10.38410927
120ICK0.38131629
121CLK10.36669164
122INSRR0.36585877
123NEK90.36548121
124AURKA0.36025982
125RPS6KB10.35508485
126TYK20.33556390
127FGFR10.33475116
128JAK20.32137810
129CSNK2A20.31499953
130RPS6KA60.31431403
131RPS6KC10.31396778
132RPS6KL10.31396778
133MAP3K10.30893672
134STK30.30885171
135AKT20.30197159
136MAPKAPK20.30082040
137TBK10.29877363
138ATM0.29202824
139JAK30.25434935

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.33800477
2One carbon pool by folate_Homo sapiens_hsa006703.11823952
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.93565198
4Selenocompound metabolism_Homo sapiens_hsa004502.88859948
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.81384253
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.75355870
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.47998226
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.36294348
9Mismatch repair_Homo sapiens_hsa034302.22964662
10Base excision repair_Homo sapiens_hsa034102.12012363
11RNA transport_Homo sapiens_hsa030132.11499136
12Spliceosome_Homo sapiens_hsa030402.02768428
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.94480789
14Biosynthesis of amino acids_Homo sapiens_hsa012301.88147418
15* Protein export_Homo sapiens_hsa030601.83771867
16Ribosome_Homo sapiens_hsa030101.76801629
17N-Glycan biosynthesis_Homo sapiens_hsa005101.75601665
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.65231714
19Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.60334931
20Carbon metabolism_Homo sapiens_hsa012001.59347011
21Galactose metabolism_Homo sapiens_hsa000521.54164128
22Cell cycle_Homo sapiens_hsa041101.49540710
23Prion diseases_Homo sapiens_hsa050201.46788753
24Folate biosynthesis_Homo sapiens_hsa007901.45555342
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43312958
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.36815564
27Non-homologous end-joining_Homo sapiens_hsa034501.35440742
28Antigen processing and presentation_Homo sapiens_hsa046121.29599692
29Pentose phosphate pathway_Homo sapiens_hsa000301.27729352
30Proteasome_Homo sapiens_hsa030501.20059869
31Fat digestion and absorption_Homo sapiens_hsa049751.19556593
32Nucleotide excision repair_Homo sapiens_hsa034201.17777295
33Fructose and mannose metabolism_Homo sapiens_hsa000511.16179897
34Shigellosis_Homo sapiens_hsa051311.15474720
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.10342705
36Lysine degradation_Homo sapiens_hsa003101.09555094
37Homologous recombination_Homo sapiens_hsa034401.08520045
38Vibrio cholerae infection_Homo sapiens_hsa051101.06762968
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05184432
40Sulfur relay system_Homo sapiens_hsa041221.03851185
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02873626
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99657916
43Legionellosis_Homo sapiens_hsa051340.95878677
44Central carbon metabolism in cancer_Homo sapiens_hsa052300.95469603
45RNA degradation_Homo sapiens_hsa030180.94129483
46Chronic myeloid leukemia_Homo sapiens_hsa052200.90418952
47Pancreatic cancer_Homo sapiens_hsa052120.89869879
48Other glycan degradation_Homo sapiens_hsa005110.88974571
49Pyrimidine metabolism_Homo sapiens_hsa002400.87056522
50Starch and sucrose metabolism_Homo sapiens_hsa005000.85395361
51mRNA surveillance pathway_Homo sapiens_hsa030150.85322711
52Bladder cancer_Homo sapiens_hsa052190.82416354
53Thyroid cancer_Homo sapiens_hsa052160.81532402
54Pyruvate metabolism_Homo sapiens_hsa006200.81456813
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.80626833
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79564063
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.79006600
58Acute myeloid leukemia_Homo sapiens_hsa052210.77486918
59Insulin resistance_Homo sapiens_hsa049310.77330265
60Protein digestion and absorption_Homo sapiens_hsa049740.77154864
61HTLV-I infection_Homo sapiens_hsa051660.76234363
62Viral carcinogenesis_Homo sapiens_hsa052030.76122200
63p53 signaling pathway_Homo sapiens_hsa041150.74824353
64Fatty acid degradation_Homo sapiens_hsa000710.74668101
65Fatty acid elongation_Homo sapiens_hsa000620.73741694
66Steroid biosynthesis_Homo sapiens_hsa001000.70542072
67Oocyte meiosis_Homo sapiens_hsa041140.69318548
68Phenylalanine metabolism_Homo sapiens_hsa003600.68651144
69MicroRNAs in cancer_Homo sapiens_hsa052060.67626815
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66450539
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66261324
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65987368
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65286319
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65071546
75Epstein-Barr virus infection_Homo sapiens_hsa051690.64644215
76Vitamin B6 metabolism_Homo sapiens_hsa007500.64467740
77mTOR signaling pathway_Homo sapiens_hsa041500.64414325
78Renal cell carcinoma_Homo sapiens_hsa052110.64178447
79Small cell lung cancer_Homo sapiens_hsa052220.63055803
80Fanconi anemia pathway_Homo sapiens_hsa034600.62298194
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61399395
82Primary immunodeficiency_Homo sapiens_hsa053400.60801725
83Renin-angiotensin system_Homo sapiens_hsa046140.59885701
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57043306
85Pancreatic secretion_Homo sapiens_hsa049720.56642762
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56044041
87Propanoate metabolism_Homo sapiens_hsa006400.55836717
88Salmonella infection_Homo sapiens_hsa051320.55349785
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55261873
90Prostate cancer_Homo sapiens_hsa052150.54977874
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54977151
92Hippo signaling pathway_Homo sapiens_hsa043900.54395378
93Glucagon signaling pathway_Homo sapiens_hsa049220.52922288
94HIF-1 signaling pathway_Homo sapiens_hsa040660.52785954
95Insulin signaling pathway_Homo sapiens_hsa049100.52389852
96Sulfur metabolism_Homo sapiens_hsa009200.51621530
97Lysosome_Homo sapiens_hsa041420.49774391
98Notch signaling pathway_Homo sapiens_hsa043300.48677975
99AMPK signaling pathway_Homo sapiens_hsa041520.48083232
100Endocytosis_Homo sapiens_hsa041440.46869586
101RNA polymerase_Homo sapiens_hsa030200.46035407
102Purine metabolism_Homo sapiens_hsa002300.45730693
103Glioma_Homo sapiens_hsa052140.45439021
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44998103
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44989666
106Arginine biosynthesis_Homo sapiens_hsa002200.44872247
107Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44385921
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44240660
109Tryptophan metabolism_Homo sapiens_hsa003800.44210971
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42845495
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42045224
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.41563500
113Apoptosis_Homo sapiens_hsa042100.41322684
114Glutathione metabolism_Homo sapiens_hsa004800.39573883
115Herpes simplex infection_Homo sapiens_hsa051680.39484935
116Non-small cell lung cancer_Homo sapiens_hsa052230.38590846
117Arginine and proline metabolism_Homo sapiens_hsa003300.38481258
118Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37784122
119Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37444190
120VEGF signaling pathway_Homo sapiens_hsa043700.37252867
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36990147
122ErbB signaling pathway_Homo sapiens_hsa040120.35984947
123Adherens junction_Homo sapiens_hsa045200.35422366
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.35318933
125Fatty acid metabolism_Homo sapiens_hsa012120.34855451
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34814225
127Focal adhesion_Homo sapiens_hsa045100.30829157
128Proteoglycans in cancer_Homo sapiens_hsa052050.30796113
129Hepatitis B_Homo sapiens_hsa051610.29387106
130Endometrial cancer_Homo sapiens_hsa052130.28162309
131beta-Alanine metabolism_Homo sapiens_hsa004100.27109670
132Viral myocarditis_Homo sapiens_hsa054160.25583463

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