SRP68P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuronal action potential propagation (GO:0019227)8.86581617
2histone H3-K9 demethylation (GO:0033169)6.87069334
3positive regulation of protein homooligomerization (GO:0032464)6.11454115
4gamma-aminobutyric acid transport (GO:0015812)5.73788792
5Peyers patch development (GO:0048541)5.06844173
6mucosal-associated lymphoid tissue development (GO:0048537)5.06844173
7cytoplasmic mRNA processing body assembly (GO:0033962)4.80642965
8detection of light stimulus involved in visual perception (GO:0050908)4.18233618
9detection of light stimulus involved in sensory perception (GO:0050962)4.18233618
10striated muscle atrophy (GO:0014891)4.12787725
11interkinetic nuclear migration (GO:0022027)4.05540968
12regulation of RNA export from nucleus (GO:0046831)3.98672086
13monoubiquitinated protein deubiquitination (GO:0035520)3.98503876
14muscle atrophy (GO:0014889)3.96735346
15positive regulation of DNA-templated transcription, initiation (GO:2000144)3.91525124
16protein dealkylation (GO:0008214)3.90911021
17protein demethylation (GO:0006482)3.90911021
18regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.88083917
19skeletal muscle adaptation (GO:0043501)3.83655975
20alternative mRNA splicing, via spliceosome (GO:0000380)3.80637335
21positive regulation of mitochondrial fission (GO:0090141)3.75796311
22pyrimidine dimer repair (GO:0006290)3.67085686
23regulation of mRNA catabolic process (GO:0061013)3.67011068
24acrosome reaction (GO:0007340)3.65968073
25mitochondrion morphogenesis (GO:0070584)3.64494782
26regulation of exit from mitosis (GO:0007096)3.63589705
27histone H2A acetylation (GO:0043968)3.61970240
28regulation of chromatin binding (GO:0035561)3.61705057
29generation of neurons (GO:0048699)3.53472806
30DNA replication-dependent nucleosome organization (GO:0034723)3.53177792
31DNA replication-dependent nucleosome assembly (GO:0006335)3.53177792
32histone demethylation (GO:0016577)3.51773369
33regulation of nucleobase-containing compound transport (GO:0032239)3.49122846
34regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.48663067
35mitotic G2 DNA damage checkpoint (GO:0007095)3.44471759
36protein-chromophore linkage (GO:0018298)3.43599897
37hepatocyte apoptotic process (GO:0097284)3.43164520
38cell wall macromolecule catabolic process (GO:0016998)3.39930159
39histone lysine demethylation (GO:0070076)3.39816700
40positive regulation of mRNA catabolic process (GO:0061014)3.38233933
41regulation of voltage-gated calcium channel activity (GO:1901385)3.35608915
42mitochondrial fission (GO:0000266)3.35044277
43serotonin metabolic process (GO:0042428)3.34098433
44male meiosis (GO:0007140)3.31940573
45negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.29042671
46regulation of mRNA splicing, via spliceosome (GO:0048024)3.27228436
47gamma-aminobutyric acid signaling pathway (GO:0007214)3.26590195
48adaptation of signaling pathway (GO:0023058)3.19110631
49primary amino compound metabolic process (GO:1901160)3.18101869
50positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.17221656
51ventricular septum development (GO:0003281)3.16843075
52epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.15608232
53protein K48-linked deubiquitination (GO:0071108)3.12646797
54positive regulation of cardiac muscle cell differentiation (GO:2000727)3.11493087
55endothelial tube morphogenesis (GO:0061154)3.11407880
56morphogenesis of an endothelium (GO:0003159)3.11407880
57N-terminal protein amino acid acetylation (GO:0006474)3.08292156
58seminiferous tubule development (GO:0072520)3.07417777
59regulation of mRNA metabolic process (GO:1903311)3.05493916
60thymus development (GO:0048538)3.03606749
61positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.02022658
62regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.02022658
63negative regulation of TOR signaling (GO:0032007)3.01718811
64replication fork processing (GO:0031297)3.01608358
65positive regulation of dendritic spine morphogenesis (GO:0061003)2.99164670
66positive regulation of dendrite morphogenesis (GO:0050775)2.98864912
67negative regulation of translation, ncRNA-mediated (GO:0040033)2.96956963
68regulation of translation, ncRNA-mediated (GO:0045974)2.96956963
69negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.96956963
70regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.94517468
71meiotic cell cycle (GO:0051321)2.94460232
72regulation of inositol phosphate biosynthetic process (GO:0010919)2.93831362
73Notch signaling involved in heart development (GO:0061314)2.93169125
74regulation of mRNA processing (GO:0050684)2.91013633
75regulation of protein oligomerization (GO:0032459)2.87963959
76mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.86504296
77positive regulation of protein oligomerization (GO:0032461)2.86426200
78retinal rod cell development (GO:0046548)2.85745627
79response to methylmercury (GO:0051597)2.85649796
80adult walking behavior (GO:0007628)2.85281844
81positive regulation of histone H3-K4 methylation (GO:0051571)2.84364663
82positive regulation of mRNA metabolic process (GO:1903313)2.83956535
83mitotic G2/M transition checkpoint (GO:0044818)2.83019689
84mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.82443075
85regulation of mRNA 3-end processing (GO:0031440)2.82322642
86regulation of protein homooligomerization (GO:0032462)2.82320446
87epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.80839225
88peroxisome fission (GO:0016559)2.79983858
89negative thymic T cell selection (GO:0045060)2.79735624
90somatic hypermutation of immunoglobulin genes (GO:0016446)2.77237847
91somatic diversification of immune receptors via somatic mutation (GO:0002566)2.77237847
92cardiac septum development (GO:0003279)2.74679124
93negative regulation of mast cell activation (GO:0033004)2.74174152
94positive regulation of mRNA 3-end processing (GO:0031442)2.74159106
95potassium ion export (GO:0071435)2.73428820
96startle response (GO:0001964)2.72129780
97regulation of timing of cell differentiation (GO:0048505)2.71366755
98tyrosine phosphorylation of STAT protein (GO:0007260)2.71236222
99regulation of mitochondrial fission (GO:0090140)2.70195341
100mitochondrial RNA metabolic process (GO:0000959)2.66917248

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.47604132
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.09655326
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.66139837
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.52558849
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse4.03980130
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.74198155
7VDR_22108803_ChIP-Seq_LS180_Human3.68516656
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.39814336
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.87027589
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.76847119
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48859915
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.44197815
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26008250
14TAF15_26573619_Chip-Seq_HEK293_Human2.18118490
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06791477
16POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98470707
17IRF1_19129219_ChIP-ChIP_H3396_Human1.94297105
18FOXM1_23109430_ChIP-Seq_U2OS_Human1.92072168
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.91217480
20GBX2_23144817_ChIP-Seq_PC3_Human1.91178219
21IGF1R_20145208_ChIP-Seq_DFB_Human1.90048449
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.88084414
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87598587
24GATA1_22025678_ChIP-Seq_K562_Human1.86493318
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.84421998
26STAT3_23295773_ChIP-Seq_U87_Human1.71363014
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61669509
28TP63_19390658_ChIP-ChIP_HaCaT_Human1.58794461
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58432656
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52729710
31E2F7_22180533_ChIP-Seq_HELA_Human1.52073737
32MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51215648
33ZNF274_21170338_ChIP-Seq_K562_Hela1.45335254
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.44037649
35RNF2_27304074_Chip-Seq_NSC_Mouse1.43029044
36BCAT_22108803_ChIP-Seq_LS180_Human1.42935711
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42715579
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40722718
39P300_19829295_ChIP-Seq_ESCs_Human1.39559620
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38711199
41AR_21572438_ChIP-Seq_LNCaP_Human1.36905633
42EWS_26573619_Chip-Seq_HEK293_Human1.34915424
43RUNX2_22187159_ChIP-Seq_PCA_Human1.33195058
44SMAD4_21799915_ChIP-Seq_A2780_Human1.31921497
45TP53_16413492_ChIP-PET_HCT116_Human1.30133505
46TCF4_23295773_ChIP-Seq_U87_Human1.27786347
47TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.24430578
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23339485
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.22994061
50ER_23166858_ChIP-Seq_MCF-7_Human1.22925199
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21133643
52ELK1_19687146_ChIP-ChIP_HELA_Human1.21099084
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.20231560
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19085283
55MYC_18940864_ChIP-ChIP_HL60_Human1.19021247
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16277648
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09771323
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08707404
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08645009
60TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07473308
61GATA3_26560356_Chip-Seq_TH2_Human1.07134312
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.04984283
63LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04660108
64SOX9_26525672_Chip-Seq_HEART_Mouse1.04560847
65SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.03797215
66CIITA_25753668_ChIP-Seq_RAJI_Human1.03075513
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02971377
68AR_25329375_ChIP-Seq_VCAP_Human1.02850051
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.00768391
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00017227
71FUS_26573619_Chip-Seq_HEK293_Human0.99566414
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99523887
73STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.99516413
74JUN_21703547_ChIP-Seq_K562_Human0.98476116
75SOX2_16153702_ChIP-ChIP_HESCs_Human0.96490494
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95910383
77TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95199237
78CRX_20693478_ChIP-Seq_RETINA_Mouse0.93621039
79FLI1_21867929_ChIP-Seq_TH2_Mouse0.93433087
80SMAD3_21741376_ChIP-Seq_HESCs_Human0.92607748
81GATA3_26560356_Chip-Seq_TH1_Human0.89721882
82FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89151509
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89107818
84CBP_20019798_ChIP-Seq_JUKART_Human0.89107818
85EGR1_19374776_ChIP-ChIP_THP-1_Human0.88812832
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87751737
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86545151
88FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.85433265
89OCT4_21477851_ChIP-Seq_ESCs_Mouse0.85187125
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84775690
91YAP1_20516196_ChIP-Seq_MESCs_Mouse0.83904326
92NANOG_18555785_Chip-Seq_ESCs_Mouse0.83778814
93SMAD4_21741376_ChIP-Seq_EPCs_Human0.83462751
94RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82732433
95NFE2_27457419_Chip-Seq_LIVER_Mouse0.82447750
96RXR_22108803_ChIP-Seq_LS180_Human0.82375708
97MYB_26560356_Chip-Seq_TH2_Human0.82351250
98GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.80931760
99KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.80845328
100AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80633660

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.43903670
2MP0002837_dystrophic_cardiac_calcinosis3.88603142
3MP0001346_abnormal_lacrimal_gland3.57350727
4MP0005645_abnormal_hypothalamus_physiol3.51595341
5MP0003646_muscle_fatigue3.44722515
6MP0010094_abnormal_chromosome_stability2.83944670
7MP0009046_muscle_twitch2.76378262
8MP0005623_abnormal_meninges_morphology2.72469583
9MP0003656_abnormal_erythrocyte_physiolo2.63874337
10MP0004084_abnormal_cardiac_muscle2.63838394
11MP0002163_abnormal_gland_morphology2.53252652
12MP0001348_abnormal_lacrimal_gland2.35846682
13MP0002396_abnormal_hematopoietic_system2.28417055
14MP0002102_abnormal_ear_morphology2.27984041
15MP0004885_abnormal_endolymph1.86185009
16MP0005379_endocrine/exocrine_gland_phen1.73774298
17MP0003763_abnormal_thymus_physiology1.71808581
18MP0008789_abnormal_olfactory_epithelium1.65127619
19MP0005171_absent_coat_pigmentation1.64970326
20MP0005671_abnormal_response_to1.59294519
21MP0004742_abnormal_vestibular_system1.59246584
22MP0005174_abnormal_tail_pigmentation1.52812741
23MP0001502_abnormal_circadian_rhythm1.52008584
24MP0003950_abnormal_plasma_membrane1.51986617
25MP0000371_diluted_coat_color1.48922368
26MP0003943_abnormal_hepatobiliary_system1.42069489
27MP0005248_abnormal_Harderian_gland1.34686820
28MP0005310_abnormal_salivary_gland1.33805146
29MP0004147_increased_porphyrin_level1.32354405
30MP0008057_abnormal_DNA_replication1.31689005
31MP0004859_abnormal_synaptic_plasticity1.31463769
32MP0002272_abnormal_nervous_system1.30758090
33MP0000631_abnormal_neuroendocrine_gland1.30311524
34MP0002160_abnormal_reproductive_system1.30053992
35MP0001486_abnormal_startle_reflex1.29868445
36MP0004036_abnormal_muscle_relaxation1.27191987
37MP0005076_abnormal_cell_differentiation1.24912882
38MP0006292_abnormal_olfactory_placode1.23837056
39MP0003866_abnormal_defecation1.21275515
40MP0002751_abnormal_autonomic_nervous1.19223681
41MP0005389_reproductive_system_phenotype1.19004359
42MP0000685_abnormal_immune_system1.18347506
43MP0001119_abnormal_female_reproductive1.14000256
44MP0001929_abnormal_gametogenesis1.13866429
45MP0001177_atelectasis1.12277952
46MP0009745_abnormal_behavioral_response1.08589549
47MP0002210_abnormal_sex_determination1.07444501
48MP0001542_abnormal_bone_strength1.04156863
49MP0008775_abnormal_heart_ventricle1.04104944
50MP0008058_abnormal_DNA_repair1.04006694
51MP0005083_abnormal_biliary_tract1.01421806
52MP0002067_abnormal_sensory_capabilities0.98606339
53MP0005647_abnormal_sex_gland0.97577084
54MP0006072_abnormal_retinal_apoptosis0.97099505
55MP0005220_abnormal_exocrine_pancreas0.96420624
56MP0003136_yellow_coat_color0.96203194
57MP0002009_preneoplasia0.95929168
58MP0005551_abnormal_eye_electrophysiolog0.95311707
59MP0003938_abnormal_ear_development0.94789273
60MP0003936_abnormal_reproductive_system0.94708786
61MP0003385_abnormal_body_wall0.94194189
62MP0003828_pulmonary_edema0.93961180
63MP0005394_taste/olfaction_phenotype0.93678530
64MP0005499_abnormal_olfactory_system0.93678530
65MP0004924_abnormal_behavior0.92915624
66MP0005386_behavior/neurological_phenoty0.92915624
67MP0000639_abnormal_adrenal_gland0.90278012
68MP0004233_abnormal_muscle_weight0.89364669
69MP0002557_abnormal_social/conspecific_i0.89110695
70MP0005451_abnormal_body_composition0.88815074
71MP0000653_abnormal_sex_gland0.87658524
72MP0002075_abnormal_coat/hair_pigmentati0.87076320
73MP0003115_abnormal_respiratory_system0.86972801
74MP0003878_abnormal_ear_physiology0.86794535
75MP0005377_hearing/vestibular/ear_phenot0.86794535
76MP0008877_abnormal_DNA_methylation0.86436367
77MP0001919_abnormal_reproductive_system0.83929855
78MP0003890_abnormal_embryonic-extraembry0.83843468
79MP0001485_abnormal_pinna_reflex0.83259252
80MP0001963_abnormal_hearing_physiology0.82346490
81MP0003183_abnormal_peptide_metabolism0.82037448
82MP0003880_abnormal_central_pattern0.81453587
83MP0000733_abnormal_muscle_development0.80329388
84MP0003755_abnormal_palate_morphology0.80315778
85MP0002277_abnormal_respiratory_mucosa0.79880598
86MP0000778_abnormal_nervous_system0.79372557
87MP0000703_abnormal_thymus_morphology0.77404889
88MP0002095_abnormal_skin_pigmentation0.77368356
89MP0002938_white_spotting0.76839057
90MP0000613_abnormal_salivary_gland0.76048439
91MP0003635_abnormal_synaptic_transmissio0.74861687
92MP0000751_myopathy0.74043807
93MP0001340_abnormal_eyelid_morphology0.73939061
94MP0002572_abnormal_emotion/affect_behav0.73039053
95MP0003787_abnormal_imprinting0.72789838
96MP0003283_abnormal_digestive_organ0.72354778
97MP0001800_abnormal_humoral_immune0.71172469
98MP0003693_abnormal_embryo_hatching0.71108778
99MP0009697_abnormal_copulation0.69575877
100MP0005410_abnormal_fertilization0.69436137

Predicted human phenotypes

RankGene SetZ-score
1Bilateral sensorineural hearing impairment (HP:0008619)5.26599286
2Aplasia cutis congenita (HP:0001057)5.01271135
3Acute lymphatic leukemia (HP:0006721)4.91460234
4Gaze-evoked nystagmus (HP:0000640)4.83009728
5Fair hair (HP:0002286)4.66555668
6Skull defect (HP:0001362)4.39719537
7Autoimmune hemolytic anemia (HP:0001890)4.23303259
8Abnormal hair whorl (HP:0010721)3.96301180
9Rectovaginal fistula (HP:0000143)3.85142072
10Rectal fistula (HP:0100590)3.85142072
11Abnormality of dentin (HP:0010299)3.64598338
12Hyperventilation (HP:0002883)3.63470546
13Tinnitus (HP:0000360)3.48408758
14Intestinal fistula (HP:0100819)3.48340886
15Generalized hypopigmentation of hair (HP:0011358)3.25650447
16Septate vagina (HP:0001153)3.11086994
17Adactyly (HP:0009776)3.10151933
18Vaginal fistula (HP:0004320)3.06506130
19Hypoproteinemia (HP:0003075)3.04399391
20Hypoplastic nipples (HP:0002557)3.03756651
21Pancreatic fibrosis (HP:0100732)3.02637894
22Recurrent bronchitis (HP:0002837)2.99613210
23Curly hair (HP:0002212)2.97434607
24Febrile seizures (HP:0002373)2.94956729
25B lymphocytopenia (HP:0010976)2.94610296
26Focal motor seizures (HP:0011153)2.88394749
27Birth length less than 3rd percentile (HP:0003561)2.77116232
28Concave nail (HP:0001598)2.77105456
29Widely spaced teeth (HP:0000687)2.74946810
30Autoimmune thrombocytopenia (HP:0001973)2.66890694
31Abnormal delayed hypersensitivity skin test (HP:0002963)2.65906027
32Facial cleft (HP:0002006)2.63993007
33Atonic seizures (HP:0010819)2.63495897
34Molar tooth sign on MRI (HP:0002419)2.63059427
35Abnormality of midbrain morphology (HP:0002418)2.63059427
36Abnormality of incisor morphology (HP:0011063)2.61974014
37Horizontal nystagmus (HP:0000666)2.58790217
38Cortical visual impairment (HP:0100704)2.55104332
39Aplasia/Hypoplasia of the tibia (HP:0005772)2.53681071
40Abnormality of the dental pulp (HP:0006479)2.51682287
41Volvulus (HP:0002580)2.48929100
42Abnormality of B cell number (HP:0010975)2.43202923
43Congenital hepatic fibrosis (HP:0002612)2.42218587
44Short tibia (HP:0005736)2.35987514
45Aplasia/Hypoplasia of the nipples (HP:0006709)2.35670114
46Abnormality of the incisor (HP:0000676)2.35435233
47Hyperlipoproteinemia (HP:0010980)2.33690583
48Pancreatic cysts (HP:0001737)2.33626090
49Abnormality of the nasolacrimal system (HP:0000614)2.31481778
50Median cleft lip (HP:0000161)2.26096339
51Aplasia/Hypoplasia of the tongue (HP:0010295)2.25204268
52Tubular atrophy (HP:0000092)2.21295179
53Nephronophthisis (HP:0000090)2.20486834
54Bowel diverticulosis (HP:0005222)2.16912264
55Deep philtrum (HP:0002002)2.15529200
56Hypochromic microcytic anemia (HP:0004840)2.11012465
57Tubulointerstitial fibrosis (HP:0005576)2.08475601
58Cubitus valgus (HP:0002967)2.07399272
59Flat occiput (HP:0005469)2.05107293
60Preaxial hand polydactyly (HP:0001177)2.03739601
61Porencephaly (HP:0002132)2.03732958
62Cystic hygroma (HP:0000476)2.03635805
63Progressive cerebellar ataxia (HP:0002073)2.01847392
64Abnormality of the renal medulla (HP:0100957)2.01576553
65True hermaphroditism (HP:0010459)2.00196619
66Focal seizures (HP:0007359)2.00166116
67Relative macrocephaly (HP:0004482)1.93978437
68Intestinal atresia (HP:0011100)1.93170141
69Inappropriate behavior (HP:0000719)1.89368146
70Long nose (HP:0003189)1.89009285
71Hyperglycinemia (HP:0002154)1.86969924
72Low anterior hairline (HP:0000294)1.84692241
73Keratoconus (HP:0000563)1.82833813
74Increased corneal curvature (HP:0100692)1.82833813
75Anteriorly placed anus (HP:0001545)1.82053403
76Drooling (HP:0002307)1.80858063
77Chronic hepatic failure (HP:0100626)1.80190683
78Submucous cleft hard palate (HP:0000176)1.78444212
79Epileptic encephalopathy (HP:0200134)1.77761096
80Abnormality of the pons (HP:0007361)1.76193556
812-3 toe syndactyly (HP:0004691)1.75061368
82Glioma (HP:0009733)1.74746639
83Portal hypertension (HP:0001409)1.74593551
84Agammaglobulinemia (HP:0004432)1.73762651
85Thickened helices (HP:0000391)1.73054541
86Abnormality of the antihelix (HP:0009738)1.71809331
87Excessive salivation (HP:0003781)1.71070207
88Bronchitis (HP:0012387)1.69501503
89Short ribs (HP:0000773)1.67025637
90Aplasia/Hypoplasia of the lens (HP:0008063)1.66916532
91Bifid tongue (HP:0010297)1.66786540
92Clitoromegaly (HP:0000057)1.66562615
93Narrow forehead (HP:0000341)1.66130170
94Cystic liver disease (HP:0006706)1.65773280
95Panhypogammaglobulinemia (HP:0003139)1.64886719
96Exocrine pancreatic insufficiency (HP:0001738)1.64619105
97Highly arched eyebrow (HP:0002553)1.64209998
98Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.64157442
99Tapered finger (HP:0001182)1.63026659
100Abnormality of T cell physiology (HP:0011840)1.61343691

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCR4.64215474
2PKN14.52724401
3BRSK24.27841683
4ZAK2.92129199
5PIK3CA2.81747461
6EPHA32.75152848
7VRK12.65181798
8MAP3K102.47325997
9CDK122.33426206
10MAP3K42.23487600
11MKNK22.15362209
12BRD42.09274597
13MARK32.06859161
14TLK11.87718267
15MAP3K91.86231637
16BRSK11.83495844
17TRIM281.80569421
18PLK41.68731627
19MKNK11.66915061
20SIK31.55788705
21IRAK11.55252913
22PAK31.53875061
23MAPK131.43962008
24STK161.39351301
25EIF2AK31.28135339
26MAP3K61.25484743
27EEF2K1.24303151
28EPHA41.22698404
29CDC71.16717372
30CHEK21.15710846
31TNIK1.15219248
32KSR21.10018804
33TSSK61.07959497
34PTK2B1.07352999
35FRK1.05776266
36SRPK11.01917589
37RAF10.99094042
38PRKCQ0.98072934
39STK30.95097400
40PIK3CG0.92213989
41CAMKK20.88247212
42NEK90.87191870
43CDK30.84712241
44MELK0.81665436
45MAPKAPK20.81462682
46MAP3K130.77239180
47BRAF0.77067188
48WNK30.77034190
49ARAF0.74888282
50AKT30.74493342
51PLK30.73313927
52SGK20.73197844
53CAMK10.71680757
54STK40.68393058
55MOS0.68186185
56CDK80.67342158
57RET0.65549152
58MAPK80.64233387
59CDK10.63831201
60CDK70.62902492
61KSR10.62800239
62RPS6KB10.62638331
63AURKA0.61747706
64RPS6KA50.60939108
65NTRK20.59687780
66ATR0.57312952
67ERBB30.55885337
68IRAK40.55837663
69MAP2K40.55075494
70MAP2K70.53953651
71CAMK40.52987299
72SIK20.52481604
73CHEK10.52444926
74PLK10.52241862
75FGFR30.51437790
76ATM0.51432239
77DYRK30.51123557
78CDK20.50503338
79TAOK30.50168154
80GSK3B0.49831832
81PRKCD0.49355550
82CSNK1D0.47896222
83CAMK1D0.47492680
84MINK10.44710522
85NEK60.42117509
86NLK0.41981346
87YES10.38213294
88CDK50.37310791
89PDGFRB0.37288985
90FER0.35542687
91SYK0.34613180
92MAP3K80.33718847
93MAPK110.32619767
94BUB10.32201948
95ROCK10.31554317
96CDK90.31549034
97SGK30.31519913
98RIPK40.31254276
99MAP2K10.31248390
100TNK20.30907312

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053224.48868722
2Alcoholism_Homo sapiens_hsa050343.48256533
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.95947627
4Non-homologous end-joining_Homo sapiens_hsa034502.53117751
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.43930554
6Linoleic acid metabolism_Homo sapiens_hsa005912.35596406
7Lysine degradation_Homo sapiens_hsa003102.32184763
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.19298448
9Allograft rejection_Homo sapiens_hsa053302.07321411
10Dorso-ventral axis formation_Homo sapiens_hsa043202.05589116
11Autoimmune thyroid disease_Homo sapiens_hsa053201.97538296
12Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.66997968
13Fanconi anemia pathway_Homo sapiens_hsa034601.66882439
14Homologous recombination_Homo sapiens_hsa034401.65289966
15Graft-versus-host disease_Homo sapiens_hsa053321.64377337
16Asthma_Homo sapiens_hsa053101.60975290
17Primary immunodeficiency_Homo sapiens_hsa053401.60879789
18Cell cycle_Homo sapiens_hsa041101.57503148
19Viral carcinogenesis_Homo sapiens_hsa052031.54329895
20Mismatch repair_Homo sapiens_hsa034301.50210987
21Ether lipid metabolism_Homo sapiens_hsa005651.46585332
22DNA replication_Homo sapiens_hsa030301.35277407
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26459764
24Ovarian steroidogenesis_Homo sapiens_hsa049131.23711384
25Transcriptional misregulation in cancer_Homo sapiens_hsa052021.23645357
26Nitrogen metabolism_Homo sapiens_hsa009101.22890576
27Type I diabetes mellitus_Homo sapiens_hsa049401.14171409
28MicroRNAs in cancer_Homo sapiens_hsa052061.11223556
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07976382
30Prolactin signaling pathway_Homo sapiens_hsa049171.05241407
31Oocyte meiosis_Homo sapiens_hsa041141.04138787
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03568209
33B cell receptor signaling pathway_Homo sapiens_hsa046621.03241700
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01761359
35Non-small cell lung cancer_Homo sapiens_hsa052231.00101183
36Chronic myeloid leukemia_Homo sapiens_hsa052200.98878282
37RNA degradation_Homo sapiens_hsa030180.98640097
38Base excision repair_Homo sapiens_hsa034100.97382581
39Melanoma_Homo sapiens_hsa052180.93687075
40Cysteine and methionine metabolism_Homo sapiens_hsa002700.93377753
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93145608
42p53 signaling pathway_Homo sapiens_hsa041150.92164947
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88647318
44Long-term depression_Homo sapiens_hsa047300.85678725
45Glioma_Homo sapiens_hsa052140.81711934
46MAPK signaling pathway_Homo sapiens_hsa040100.79889479
47TNF signaling pathway_Homo sapiens_hsa046680.77957123
48Pancreatic cancer_Homo sapiens_hsa052120.77290129
49Steroid biosynthesis_Homo sapiens_hsa001000.76472607
50Leishmaniasis_Homo sapiens_hsa051400.75888337
51Long-term potentiation_Homo sapiens_hsa047200.74171257
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74011060
53Hepatitis B_Homo sapiens_hsa051610.73911652
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.73500306
55mRNA surveillance pathway_Homo sapiens_hsa030150.73366539
56Arachidonic acid metabolism_Homo sapiens_hsa005900.71364190
57Fatty acid biosynthesis_Homo sapiens_hsa000610.68802210
58One carbon pool by folate_Homo sapiens_hsa006700.68566083
59Antigen processing and presentation_Homo sapiens_hsa046120.68353165
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67428727
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66643014
62Spliceosome_Homo sapiens_hsa030400.65362695
63Measles_Homo sapiens_hsa051620.64973466
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63244030
65FoxO signaling pathway_Homo sapiens_hsa040680.61819790
66Epstein-Barr virus infection_Homo sapiens_hsa051690.61537351
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61283612
68Toxoplasmosis_Homo sapiens_hsa051450.59991698
69Selenocompound metabolism_Homo sapiens_hsa004500.58971456
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57284376
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55857875
72RNA transport_Homo sapiens_hsa030130.53951922
73HTLV-I infection_Homo sapiens_hsa051660.53752152
74Apoptosis_Homo sapiens_hsa042100.53736283
75Calcium signaling pathway_Homo sapiens_hsa040200.53290516
76Inositol phosphate metabolism_Homo sapiens_hsa005620.53051588
77Nicotine addiction_Homo sapiens_hsa050330.52581057
78Oxytocin signaling pathway_Homo sapiens_hsa049210.51707660
79Influenza A_Homo sapiens_hsa051640.50858839
80Estrogen signaling pathway_Homo sapiens_hsa049150.50680486
81Herpes simplex infection_Homo sapiens_hsa051680.50470414
82Circadian rhythm_Homo sapiens_hsa047100.50031063
83Colorectal cancer_Homo sapiens_hsa052100.48850352
84Glutamatergic synapse_Homo sapiens_hsa047240.48000434
85GnRH signaling pathway_Homo sapiens_hsa049120.47903624
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47629583
87Phototransduction_Homo sapiens_hsa047440.45689258
88Butanoate metabolism_Homo sapiens_hsa006500.45296083
89Acute myeloid leukemia_Homo sapiens_hsa052210.45140721
90Olfactory transduction_Homo sapiens_hsa047400.43035118
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41600246
92Choline metabolism in cancer_Homo sapiens_hsa052310.41197549
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.40865969
94Viral myocarditis_Homo sapiens_hsa054160.39281390
95Small cell lung cancer_Homo sapiens_hsa052220.38622518
96Bladder cancer_Homo sapiens_hsa052190.38106253
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37447156
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37188437
99Cocaine addiction_Homo sapiens_hsa050300.36932507
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36912855

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