SRP72

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the 72 kDa subunit of the signal recognition particle (SRP), a ribonucleoprotein complex that mediates the targeting of secretory proteins to the endoplasmic reticulum (ER). The SRP complex consists of a 7S RNA and 6 protein subunits: SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72, that are bound to the 7S RNA as monomers or heterodimers. SRP has at least 3 distinct functions that can be associated with the protein subunits: signal recognition, translational arrest, and ER membrane targeting by interaction with the docking protein. Mutations in this gene are associated with familial bone marrow failure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)9.27648657
2COPI coating of Golgi vesicle (GO:0048205)9.27648657
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.95551515
4folic acid-containing compound biosynthetic process (GO:0009396)5.58728907
5COPII vesicle coating (GO:0048208)5.34881472
6protein retention in ER lumen (GO:0006621)5.15358358
7retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.10784224
8ribosomal large subunit biogenesis (GO:0042273)4.75212310
9activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.54987321
10positive regulation of nuclease activity (GO:0032075)4.49840289
11mitotic chromosome condensation (GO:0007076)4.24896561
12regulation of nuclease activity (GO:0032069)4.20203319
13establishment of integrated proviral latency (GO:0075713)4.18917654
14IMP biosynthetic process (GO:0006188)4.18348299
15CENP-A containing nucleosome assembly (GO:0034080)4.18259810
16formation of translation preinitiation complex (GO:0001731)4.16520946
17ribosome assembly (GO:0042255)4.15966947
18mitotic metaphase plate congression (GO:0007080)4.15641668
19DNA strand elongation involved in DNA replication (GO:0006271)4.13985780
20mitotic sister chromatid segregation (GO:0000070)4.11583891
21chromatin remodeling at centromere (GO:0031055)4.09190064
22endoplasmic reticulum unfolded protein response (GO:0030968)4.07383045
23vesicle coating (GO:0006901)4.06856648
24sister chromatid segregation (GO:0000819)4.05703612
25telomere maintenance via semi-conservative replication (GO:0032201)3.99818996
26DNA strand elongation (GO:0022616)3.97810431
27cellular response to unfolded protein (GO:0034620)3.95417161
28ribosomal small subunit assembly (GO:0000028)3.94000542
29protein maturation by protein folding (GO:0022417)3.81466423
30translational termination (GO:0006415)3.78522044
31metaphase plate congression (GO:0051310)3.78410301
32cellular response to topologically incorrect protein (GO:0035967)3.77723834
33tetrahydrofolate metabolic process (GO:0046653)3.76495759
34DNA replication checkpoint (GO:0000076)3.75703431
35signal peptide processing (GO:0006465)3.73512405
36sequestering of metal ion (GO:0051238)3.73039971
37viral transcription (GO:0019083)3.72527015
38ER-nucleus signaling pathway (GO:0006984)3.72463681
39ribosomal small subunit biogenesis (GO:0042274)3.71831410
40protein localization to chromosome, centromeric region (GO:0071459)3.70691990
41proteasome assembly (GO:0043248)3.69636324
42ribonucleoprotein complex biogenesis (GO:0022613)3.66539935
43DNA topological change (GO:0006265)3.62581168
44telomere maintenance via recombination (GO:0000722)3.60122970
45mitotic recombination (GO:0006312)3.59366220
46nuclear pore organization (GO:0006999)3.57005609
47IMP metabolic process (GO:0046040)3.54817367
48nuclear pore complex assembly (GO:0051292)3.54221707
49exocrine pancreas development (GO:0031017)3.53401884
50kinetochore organization (GO:0051383)3.51956853
51nucleobase biosynthetic process (GO:0046112)3.48389106
52regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.47308395
53DNA replication-independent nucleosome organization (GO:0034724)3.47129547
54DNA replication-independent nucleosome assembly (GO:0006336)3.47129547
55nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.44136594
56pteridine-containing compound biosynthetic process (GO:0042559)3.42519226
57regulation of centriole replication (GO:0046599)3.41768020
58histone exchange (GO:0043486)3.39166170
59establishment of chromosome localization (GO:0051303)3.34325697
60regulation of mitotic spindle organization (GO:0060236)3.32811310
61ribosome biogenesis (GO:0042254)3.32546995
62protein N-linked glycosylation via asparagine (GO:0018279)3.26946893
63negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.26891569
64translational elongation (GO:0006414)3.26767167
65peptidyl-asparagine modification (GO:0018196)3.24946095
66anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.24552600
67mitotic nuclear envelope disassembly (GO:0007077)3.24332400
68regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.23711979
69* translation (GO:0006412)3.23432847
70non-recombinational repair (GO:0000726)3.22652229
71double-strand break repair via nonhomologous end joining (GO:0006303)3.22652229
72establishment of protein localization to mitochondrial membrane (GO:0090151)3.21655405
73DNA replication initiation (GO:0006270)3.21616811
74regulation of translational fidelity (GO:0006450)3.20236886
75response to endoplasmic reticulum stress (GO:0034976)3.19777219
76spindle checkpoint (GO:0031577)3.18335635
77* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.16405594
78mitotic spindle checkpoint (GO:0071174)3.16216748
79negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.13679443
80negative regulation of mitotic sister chromatid segregation (GO:0033048)3.13679443
81negative regulation of mitotic sister chromatid separation (GO:2000816)3.13679443
82negative regulation of sister chromatid segregation (GO:0033046)3.13679443
83negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.13679443
84negative regulation of chromosome segregation (GO:0051985)3.11991387
85mitotic sister chromatid cohesion (GO:0007064)3.11815856
86positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.11370786
87UDP-N-acetylglucosamine metabolic process (GO:0006047)3.10340680
88nucleotide-excision repair, DNA gap filling (GO:0006297)3.09983142
89regulation of spindle organization (GO:0090224)3.08523673
90glucocorticoid receptor signaling pathway (GO:0042921)3.07812055
91* protein targeting to ER (GO:0045047)3.07466038
92response to unfolded protein (GO:0006986)3.07462775
93regulation of chromosome segregation (GO:0051983)3.07108489
94regulation of mitotic metaphase/anaphase transition (GO:0030071)3.06714656
95regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.06714656
96rRNA processing (GO:0006364)3.05846091
97* cotranslational protein targeting to membrane (GO:0006613)3.05414879
98purine nucleobase biosynthetic process (GO:0009113)3.04937124
99pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.04238622
100UMP metabolic process (GO:0046049)3.04238622
101pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.04238622
102UMP biosynthetic process (GO:0006222)3.04238622
103telomere maintenance via telomere lengthening (GO:0010833)3.03967186
104membrane disassembly (GO:0030397)3.03201655
105nuclear envelope disassembly (GO:0051081)3.03201655
106DNA ligation (GO:0006266)3.03137025
107mitotic spindle assembly checkpoint (GO:0007094)3.02191851
108regulation of sister chromatid segregation (GO:0033045)3.01641813
109regulation of mitotic sister chromatid separation (GO:0010965)3.01641813
110regulation of mitotic sister chromatid segregation (GO:0033047)3.01641813
111spindle assembly checkpoint (GO:0071173)2.98740183
112negative regulation of ligase activity (GO:0051352)2.97559550
113negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.97559550
114regulation of DNA endoreduplication (GO:0032875)2.96237437
115response to topologically incorrect protein (GO:0035966)2.96109237
116viral life cycle (GO:0019058)2.95461430
117* establishment of protein localization to endoplasmic reticulum (GO:0072599)2.93941728
118protein N-linked glycosylation (GO:0006487)2.93366371
119ATP-dependent chromatin remodeling (GO:0043044)2.92473817
1204-hydroxyproline metabolic process (GO:0019471)2.92278083
121cellular protein complex disassembly (GO:0043624)2.92095079
122establishment of viral latency (GO:0019043)2.91981191
123ER overload response (GO:0006983)2.88431196
124ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.87939249
125* protein localization to endoplasmic reticulum (GO:0070972)2.86135182
126ER to Golgi vesicle-mediated transport (GO:0006888)2.85901851
127DNA unwinding involved in DNA replication (GO:0006268)2.85333901
128one-carbon metabolic process (GO:0006730)2.83096416
129pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.82861876
130folic acid-containing compound metabolic process (GO:0006760)2.74820760
131type B pancreatic cell development (GO:0003323)2.72819585
132endocrine pancreas development (GO:0031018)2.71159007
133regulation of translational termination (GO:0006449)2.69076001
134pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.61984407
135protein autoprocessing (GO:0016540)2.58321383
136intra-Golgi vesicle-mediated transport (GO:0006891)2.56287643
137pore complex assembly (GO:0046931)2.54569241
138tRNA aminoacylation for protein translation (GO:0006418)2.50071863
139L-alpha-amino acid transmembrane transport (GO:1902475)2.49307947
140misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.47472683
141nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.46037957
142corticosteroid receptor signaling pathway (GO:0031958)2.45730871
143cellular response to glucose starvation (GO:0042149)2.44421547
144protein localization to kinetochore (GO:0034501)2.43136524
145tRNA aminoacylation (GO:0043039)2.43055884
146amino acid activation (GO:0043038)2.43055884
147DNA duplex unwinding (GO:0032508)2.42815309
148negative regulation of RNA splicing (GO:0033119)2.41442437
149DNA geometric change (GO:0032392)2.39287521
150positive regulation of hormone biosynthetic process (GO:0046886)2.37873063
151regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.35458769
152glandular epithelial cell development (GO:0002068)2.35031379
153regulation of glucokinase activity (GO:0033131)2.34877645
154regulation of hexokinase activity (GO:1903299)2.34877645
155chaperone-mediated protein folding (GO:0061077)2.31176143
156valine metabolic process (GO:0006573)2.29087962
157translational initiation (GO:0006413)2.29040381
158oxaloacetate metabolic process (GO:0006107)2.28836444
159glutamine metabolic process (GO:0006541)2.28183173
160proline biosynthetic process (GO:0006561)2.26032107
161positive regulation of protein import into nucleus, translocation (GO:0033160)2.25790651
162spliceosomal tri-snRNP complex assembly (GO:0000244)2.24457831
163chaperone mediated protein folding requiring cofactor (GO:0051085)2.23861323
164pteridine-containing compound metabolic process (GO:0042558)2.23241754
165negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.23233341
166maturation of SSU-rRNA (GO:0030490)2.23042711
167RNA stabilization (GO:0043489)2.22787621
168mRNA stabilization (GO:0048255)2.22787621
169cellular response to vitamin D (GO:0071305)2.20966319
170cellular zinc ion homeostasis (GO:0006882)2.20097691
171peptidyl-proline hydroxylation (GO:0019511)2.19622928

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.95774601
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.18167967
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.63661659
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.61195689
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.33369535
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.97085311
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.65466803
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.57683973
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.54240565
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.46127159
11PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.36023628
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.35588659
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.32422328
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.30316311
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.28824611
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.27630130
17MYC_22102868_ChIP-Seq_BL_Human2.20278772
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19591238
19ELK1_19687146_ChIP-ChIP_HELA_Human2.19344192
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.18618381
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.12562655
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.04071284
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02329835
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.02231023
25E2F1_21310950_ChIP-Seq_MCF-7_Human2.02064936
26* VDR_23849224_ChIP-Seq_CD4+_Human1.98276845
27FOXP3_21729870_ChIP-Seq_TREG_Human1.88708754
28ZFX_18555785_ChIP-Seq_MESCs_Mouse1.88219200
29XRN2_22483619_ChIP-Seq_HELA_Human1.86431032
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86021680
31DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.85591516
32AR_21909140_ChIP-Seq_LNCAP_Human1.85406683
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84867203
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.83673216
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.80810487
36TFEB_21752829_ChIP-Seq_HELA_Human1.78125859
37DCP1A_22483619_ChIP-Seq_HELA_Human1.77785802
38PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.74025433
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73837795
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.73739785
41* GABP_19822575_ChIP-Seq_HepG2_Human1.71925946
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.70412186
43KDM5A_27292631_Chip-Seq_BREAST_Human1.68839763
44* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.68279243
45GATA1_22025678_ChIP-Seq_K562_Human1.67919280
46ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.67203189
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64952041
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64578114
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.64130458
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.62716609
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.62116810
52CIITA_25753668_ChIP-Seq_RAJI_Human1.58521483
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58051760
54CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.56932586
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56626996
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.54591226
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.53666631
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.52216549
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51265450
60CLOCK_20551151_ChIP-Seq_293T_Human1.50689775
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.42856837
62TTF2_22483619_ChIP-Seq_HELA_Human1.40861124
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.35023188
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.33074252
65CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.32336674
66CHD1_26751641_Chip-Seq_LNCaP_Human1.29304306
67ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.25992809
68SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24267528
69MYC_18940864_ChIP-ChIP_HL60_Human1.23936975
70* SRF_21415370_ChIP-Seq_HL-1_Mouse1.23272607
71MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22334179
72CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21934363
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.19466332
74HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18546951
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18456318
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17227951
77SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.16571138
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15460860
79THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13197252
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11544829
81FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10336110
82CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09686141
83CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08129573
84PPARA_22158963_ChIP-Seq_LIVER_Mouse1.05768313
85SOX17_20123909_ChIP-Seq_XEN_Mouse1.05530378
86RXR_22158963_ChIP-Seq_LIVER_Mouse1.04674221
87EWS_26573619_Chip-Seq_HEK293_Human1.04350000
88MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03048562
89TP63_19390658_ChIP-ChIP_HaCaT_Human1.00808116
90MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00787860
91NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.00454250
92* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98208237
93* SPI1_23547873_ChIP-Seq_NB4_Human0.97763139
94NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97704385
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97452927
96KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97268593
97YY1_21170310_ChIP-Seq_MESCs_Mouse0.96906823
98NANOG_16153702_ChIP-ChIP_HESCs_Human0.95897810
99SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95741810
100SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95432948
101MYB_26560356_Chip-Seq_TH2_Human0.94532412
102BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93265048
103SALL1_21062744_ChIP-ChIP_HESCs_Human0.92379467
104IRF8_22096565_ChIP-ChIP_GC-B_Human0.91728270
105FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.89985006
106MYB_26560356_Chip-Seq_TH1_Human0.89671004
107ZNF263_19887448_ChIP-Seq_K562_Human0.89281414
108FUS_26573619_Chip-Seq_HEK293_Human0.89151889
109NOTCH1_21737748_ChIP-Seq_TLL_Human0.88067560
110HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87970349
111SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87929082
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87539487
113KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85628136
114TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85203354
115ELK1_22589737_ChIP-Seq_MCF10A_Human0.85189347
116ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.83505624
117CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83032747
118ELF5_23300383_ChIP-Seq_T47D_Human0.82786377
119NANOG_21062744_ChIP-ChIP_HESCs_Human0.82663969
120STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81724456
121TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.81377637
122SOX2_16153702_ChIP-ChIP_HESCs_Human0.79214631
123WT1_19549856_ChIP-ChIP_CCG9911_Human0.73761631
124POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.72870777

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog4.21711262
2MP0003693_abnormal_embryo_hatching3.09471959
3MP0010352_gastrointestinal_tract_polyps3.03432862
4MP0006054_spinal_hemorrhage2.74110071
5MP0005220_abnormal_exocrine_pancreas2.58138731
6MP0004957_abnormal_blastocyst_morpholog2.32101444
7MP0009379_abnormal_foot_pigmentation2.18355456
8MP0004264_abnormal_extraembryonic_tissu2.09676836
9MP0003941_abnormal_skin_development2.07965915
10MP0001944_abnormal_pancreas_morphology2.05064754
11MP0002693_abnormal_pancreas_physiology2.00333794
12MP0003806_abnormal_nucleotide_metabolis1.92777027
13MP0003718_maternal_effect1.91177869
14MP0006292_abnormal_olfactory_placode1.90403380
15MP0005365_abnormal_bile_salt1.84210037
16MP0002139_abnormal_hepatobiliary_system1.83502703
17MP0010094_abnormal_chromosome_stability1.83196994
18MP0008057_abnormal_DNA_replication1.78643443
19MP0003077_abnormal_cell_cycle1.78469872
20MP0003786_premature_aging1.75804793
21MP0008007_abnormal_cellular_replicative1.74541046
22MP0003111_abnormal_nucleus_morphology1.74343044
23MP0003123_paternal_imprinting1.72908501
24MP0003315_abnormal_perineum_morphology1.67953064
25MP0003300_gastrointestinal_ulcer1.67682711
26MP0005408_hypopigmentation1.63253262
27MP0004147_increased_porphyrin_level1.62889706
28MP0008877_abnormal_DNA_methylation1.58268530
29MP0002138_abnormal_hepatobiliary_system1.54680227
30MP0002396_abnormal_hematopoietic_system1.53936927
31MP0003195_calcinosis1.52180423
32MP0001293_anophthalmia1.51710772
33MP0005076_abnormal_cell_differentiation1.48346332
34MP0010307_abnormal_tumor_latency1.42486551
35MP0008058_abnormal_DNA_repair1.39559548
36MP0003566_abnormal_cell_adhesion1.39493643
37MP0003705_abnormal_hypodermis_morpholog1.38787536
38MP0003868_abnormal_feces_composition1.38544895
39MP0004808_abnormal_hematopoietic_stem1.38197152
40MP0001730_embryonic_growth_arrest1.36939806
41MP0003890_abnormal_embryonic-extraembry1.36500432
42MP0008438_abnormal_cutaneous_collagen1.35602103
43MP0004197_abnormal_fetal_growth/weight/1.35561351
44MP0009053_abnormal_anal_canal1.34760068
45MP0003283_abnormal_digestive_organ1.34207365
46MP0009780_abnormal_chondrocyte_physiolo1.30361571
47MP0002234_abnormal_pharynx_morphology1.27169150
48MP0010234_abnormal_vibrissa_follicle1.26485027
49MP0002896_abnormal_bone_mineralization1.25491182
50MP0000490_abnormal_crypts_of1.24977735
51MP0000350_abnormal_cell_proliferation1.23742435
52MP0002909_abnormal_adrenal_gland1.23262958
53MP0001286_abnormal_eye_development1.22543496
54MP0002009_preneoplasia1.17241513
55MP0001188_hyperpigmentation1.17061223
56MP0000013_abnormal_adipose_tissue1.13331825
57MP0003385_abnormal_body_wall1.13066551
58MP0003937_abnormal_limbs/digits/tail_de1.12339434
59MP0001697_abnormal_embryo_size1.12302908
60MP0003252_abnormal_bile_duct1.10925404
61MP0002084_abnormal_developmental_patter1.10414047
62MP0002938_white_spotting1.08517442
63MP0001666_abnormal_nutrient_absorption1.07890241
64MP0004233_abnormal_muscle_weight1.07291064
65MP0009672_abnormal_birth_weight1.07232511
66MP0002086_abnormal_extraembryonic_tissu1.06911883
67MP0010386_abnormal_urinary_bladder1.06661769
68MP0000003_abnormal_adipose_tissue1.06513279
69MP0000678_abnormal_parathyroid_gland1.06506967
70MP0003183_abnormal_peptide_metabolism1.05934541
71MP0005023_abnormal_wound_healing1.05918749
72MP0008875_abnormal_xenobiotic_pharmacok1.05453350
73MP0006035_abnormal_mitochondrial_morpho1.05298255
74MP0002080_prenatal_lethality1.04414542
75MP0003984_embryonic_growth_retardation1.03964915
76MP0001727_abnormal_embryo_implantation1.03616321
77MP0002697_abnormal_eye_size1.03522762
78MP0002088_abnormal_embryonic_growth/wei1.03515445
79MP0005503_abnormal_tendon_morphology1.02882200
80MP0001672_abnormal_embryogenesis/_devel1.01896136
81MP0005380_embryogenesis_phenotype1.01896136
82MP0009697_abnormal_copulation1.01699723
83MP0000858_altered_metastatic_potential1.01227735
84MP0005085_abnormal_gallbladder_physiolo1.00378315
85MP0000598_abnormal_liver_morphology1.00077311
86MP0003121_genomic_imprinting0.99326689
87MP0000358_abnormal_cell_content/0.98981138
88MP0005501_abnormal_skin_physiology0.98453993
89MP0002078_abnormal_glucose_homeostasis0.96825673
90MP0009703_decreased_birth_body0.94149772
91MP0001881_abnormal_mammary_gland0.93178687
92MP0003122_maternal_imprinting0.91971441
93MP0002019_abnormal_tumor_incidence0.91699662
94MP0002796_impaired_skin_barrier0.91324308
95MP0003186_abnormal_redox_activity0.90868450
96MP0002160_abnormal_reproductive_system0.89854144
97MP0000613_abnormal_salivary_gland0.89492077
98MP0005397_hematopoietic_system_phenotyp0.88881602
99MP0001545_abnormal_hematopoietic_system0.88881602
100MP0008995_early_reproductive_senescence0.88875713
101MP0003436_decreased_susceptibility_to0.88666813
102MP0002233_abnormal_nose_morphology0.88160136
103MP0002210_abnormal_sex_determination0.87377993
104MP0000537_abnormal_urethra_morphology0.86475179
105MP0000516_abnormal_urinary_system0.86243885
106MP0005367_renal/urinary_system_phenotyp0.86243885
107MP0003755_abnormal_palate_morphology0.85611709
108MP0010030_abnormal_orbit_morphology0.85447522
109MP0003950_abnormal_plasma_membrane0.85058835
110MP0002060_abnormal_skin_morphology0.84803007
111MP0002111_abnormal_tail_morphology0.84492447
112MP0008932_abnormal_embryonic_tissue0.84457717
113MP0000609_abnormal_liver_physiology0.84373666
114MP0008789_abnormal_olfactory_epithelium0.82620253
115MP0003119_abnormal_digestive_system0.82559293
116MP0000627_abnormal_mammary_gland0.82337853
117MP0003567_abnormal_fetal_cardiomyocyte0.81539587
118MP0001529_abnormal_vocalization0.80647803
119MP0003795_abnormal_bone_structure0.80303296
120MP0001915_intracranial_hemorrhage0.80114965
121MP0006036_abnormal_mitochondrial_physio0.79485312
122MP0001764_abnormal_homeostasis0.79375831
123MP0003221_abnormal_cardiomyocyte_apopto0.78938062
124MP0002092_abnormal_eye_morphology0.78496371
125MP0000569_abnormal_digit_pigmentation0.77108793
126MP0001243_abnormal_dermal_layer0.77061853
127MP0001145_abnormal_male_reproductive0.76597072
128MP0000762_abnormal_tongue_morphology0.75435928
129MP0002085_abnormal_embryonic_tissue0.75043061
130MP0003787_abnormal_imprinting0.74760224
131MP0005384_cellular_phenotype0.74742892
132MP0000703_abnormal_thymus_morphology0.74581565
133MP0005248_abnormal_Harderian_gland0.74174109
134MP0000428_abnormal_craniofacial_morphol0.74139274
135MP0003943_abnormal_hepatobiliary_system0.74091278
136MP0006072_abnormal_retinal_apoptosis0.73062918
137MP0009333_abnormal_splenocyte_physiolog0.72303232
138MP0003656_abnormal_erythrocyte_physiolo0.72160112
139MP0005621_abnormal_cell_physiology0.71937315
140MP0000313_abnormal_cell_death0.71793214
141MP0003959_abnormal_lean_body0.71757457
142MP0002166_altered_tumor_susceptibility0.71291567
143MP0000371_diluted_coat_color0.71235496
144MP0001929_abnormal_gametogenesis0.70564313
145MP0009643_abnormal_urine_homeostasis0.70024183
146MP0004272_abnormal_basement_membrane0.69863618
147MP0002006_tumorigenesis0.69333496
148MP0000647_abnormal_sebaceous_gland0.68058395
149MP0003935_abnormal_craniofacial_develop0.66976376
150MP0000653_abnormal_sex_gland0.66327441
151MP0004782_abnormal_surfactant_physiolog0.66266585
152MP0003861_abnormal_nervous_system0.64803608
153MP0003936_abnormal_reproductive_system0.63648636

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.32852133
2Hypoglycemic seizures (HP:0002173)3.99188505
3Hypoglycemic coma (HP:0001325)3.87693264
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.84103556
5Symptomatic seizures (HP:0011145)3.57147514
6Abnormality of the intrinsic pathway (HP:0010989)3.56292951
7Hyperinsulinemic hypoglycemia (HP:0000825)3.48199995
8Reticulocytopenia (HP:0001896)3.44844775
9Thrombocytosis (HP:0001894)3.44504530
10Multiple enchondromatosis (HP:0005701)3.41691815
11Macrocytic anemia (HP:0001972)3.23766922
12Abnormality of the common coagulation pathway (HP:0010990)3.09191400
13Abnormality of the pancreatic islet cells (HP:0006476)3.03559899
14Abnormality of endocrine pancreas physiology (HP:0012093)3.03559899
15Abnormality of chromosome stability (HP:0003220)2.98860113
16Cervical subluxation (HP:0003308)2.98187863
17Prominent metopic ridge (HP:0005487)2.98115225
18Increased serum pyruvate (HP:0003542)2.94002014
19Hyperglycemia (HP:0003074)2.93005937
20Abnormality of cells of the erythroid lineage (HP:0012130)2.92619504
21Abnormality of methionine metabolism (HP:0010901)2.90860270
22Abnormal lung lobation (HP:0002101)2.84208551
23Acute myeloid leukemia (HP:0004808)2.83585115
24Abnormality of glycolysis (HP:0004366)2.82914178
25Increased nuchal translucency (HP:0010880)2.82811272
26Nephroblastoma (Wilms tumor) (HP:0002667)2.81659600
27Pancreatic islet-cell hyperplasia (HP:0004510)2.79695541
28Microvesicular hepatic steatosis (HP:0001414)2.78216385
29Embryonal renal neoplasm (HP:0011794)2.74092404
3011 pairs of ribs (HP:0000878)2.71255041
31Abnormality of the metopic suture (HP:0005556)2.68333405
32Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.67957498
33Abnormality of the preputium (HP:0100587)2.66845825
34* Myelodysplasia (HP:0002863)2.62666839
35Degeneration of anterior horn cells (HP:0002398)2.61503112
36Abnormality of the anterior horn cell (HP:0006802)2.61503112
37Meckel diverticulum (HP:0002245)2.58372628
38Increased hepatocellular lipid droplets (HP:0006565)2.54645821
39Abnormal foot bone ossification (HP:0010675)2.52277531
40Beaking of vertebral bodies (HP:0004568)2.50510248
41Duodenal stenosis (HP:0100867)2.47150981
42Small intestinal stenosis (HP:0012848)2.47150981
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.47047760
44Abnormality of the ileum (HP:0001549)2.42580419
45Missing ribs (HP:0000921)2.40524623
46Limb hypertonia (HP:0002509)2.36091925
47Cortical dysplasia (HP:0002539)2.35445179
48Pallor (HP:0000980)2.33134831
49Abnormality of monocarboxylic acid metabolism (HP:0010996)2.30755102
50Colon cancer (HP:0003003)2.29565438
51Abnormal number of erythroid precursors (HP:0012131)2.28848624
52Proximal placement of thumb (HP:0009623)2.28165948
53Lipid accumulation in hepatocytes (HP:0006561)2.25569032
54Acute necrotizing encephalopathy (HP:0006965)2.20097631
55Metaphyseal cupping (HP:0003021)2.17859461
56Protrusio acetabuli (HP:0003179)2.17323626
57Abnormality of T cell physiology (HP:0011840)2.16105599
58Short middle phalanx of the 5th finger (HP:0004220)2.14502134
59Abnormal biliary tract morphology (HP:0012440)2.13455519
60Late onset (HP:0003584)2.12832449
61Abnormality of the duodenum (HP:0002246)2.12531356
62Severe short stature (HP:0003510)2.11100765
63Insulin-resistant diabetes mellitus (HP:0000831)2.10088845
64Aplasia/Hypoplasia of the sacrum (HP:0008517)2.09124818
65Rhabdomyosarcoma (HP:0002859)2.08772086
66Cutaneous melanoma (HP:0012056)2.07910579
67Thoracolumbar scoliosis (HP:0002944)2.07646891
68Neoplasm of the colon (HP:0100273)2.06994196
69Abnormality of aromatic amino acid family metabolism (HP:0004338)2.06700611
70Acute encephalopathy (HP:0006846)2.06624593
71Osteomalacia (HP:0002749)2.06097031
72Biliary tract neoplasm (HP:0100574)2.06049281
73Abnormality of the labia minora (HP:0012880)2.05855983
74Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.04030912
75Vertebral hypoplasia (HP:0008417)2.04030912
76Selective tooth agenesis (HP:0001592)2.02303042
77Abnormality of aspartate family amino acid metabolism (HP:0010899)2.01538663
78Abnormal mitochondria in muscle tissue (HP:0008316)1.99235770
79Volvulus (HP:0002580)1.98382304
80Insulin resistance (HP:0000855)1.98088124
81Mucopolysacchariduria (HP:0008155)1.95352842
82Urinary glycosaminoglycan excretion (HP:0003541)1.95352842
83Subacute progressive viral hepatitis (HP:0006572)1.94889359
84Papillary thyroid carcinoma (HP:0002895)1.93356635
85Deep philtrum (HP:0002002)1.92712532
86Mild short stature (HP:0003502)1.92538516
87Enlarged penis (HP:0000040)1.92198365
88Sensory axonal neuropathy (HP:0003390)1.92188485
89Ketoacidosis (HP:0001993)1.91436121
90Increased CSF lactate (HP:0002490)1.90645000
91Reduced antithrombin III activity (HP:0001976)1.90358991
92Type I transferrin isoform profile (HP:0003642)1.90061693
93Premature ovarian failure (HP:0008209)1.89688268
94Acute lymphatic leukemia (HP:0006721)1.88597242
95Triphalangeal thumb (HP:0001199)1.88130702
96Facial cleft (HP:0002006)1.87149160
97Overlapping toe (HP:0001845)1.85100346
98Abnormal number of incisors (HP:0011064)1.84524449
99Abnormal pancreas size (HP:0012094)1.83292902
100Horseshoe kidney (HP:0000085)1.82396769
101Postnatal microcephaly (HP:0005484)1.82292600
102Ankyloglossia (HP:0010296)1.81963666
103Long toe (HP:0010511)1.81513312
104Medulloblastoma (HP:0002885)1.80696738
105Sloping forehead (HP:0000340)1.80243883
106Cerebral edema (HP:0002181)1.79356510
107Abnormal umbilical cord blood vessels (HP:0011403)1.78791434
108Single umbilical artery (HP:0001195)1.78791434
109Abnormality of the fetal cardiovascular system (HP:0010948)1.78791434
110Abnormality of the calcaneus (HP:0008364)1.78612108
111Cafe-au-lait spot (HP:0000957)1.77946938
112Secondary amenorrhea (HP:0000869)1.77355700
113Hypoplastic labia majora (HP:0000059)1.76483707
114Intrahepatic cholestasis (HP:0001406)1.76202005
115Abnormality of the fingertips (HP:0001211)1.76162068
116Macroorchidism (HP:0000053)1.74904784
117Ectopic kidney (HP:0000086)1.74336010
118Long foot (HP:0001833)1.74119967
119Abnormality of calcium-phosphate metabolism (HP:0100530)1.73985989
120Hypoplasia of the pons (HP:0012110)1.73818261
121Hypobetalipoproteinemia (HP:0003563)1.73656413
122Deviation of the thumb (HP:0009603)1.73102322
123Respiratory difficulties (HP:0002880)1.72166279
124Increased serum lactate (HP:0002151)1.71862351
125Glossoptosis (HP:0000162)1.71367394
126Generalized aminoaciduria (HP:0002909)1.71341261
127Atresia of the external auditory canal (HP:0000413)1.70533517
128Stenosis of the external auditory canal (HP:0000402)1.70117798
129Ependymoma (HP:0002888)1.69852250
130Progressive macrocephaly (HP:0004481)1.69799167
131Optic nerve coloboma (HP:0000588)1.69608435
132Choanal atresia (HP:0000453)1.68859042
133Abnormality of the umbilical cord (HP:0010881)1.67931163
134Abnormality of homocysteine metabolism (HP:0010919)1.67776657
135Homocystinuria (HP:0002156)1.67776657
136Diastasis recti (HP:0001540)1.66532932
137Microglossia (HP:0000171)1.66017242
138Slender long bone (HP:0003100)1.65954676
139Conjugated hyperbilirubinemia (HP:0002908)1.64724869
140Capillary hemangiomas (HP:0005306)1.64458142
141Epiphyseal dysplasia (HP:0002656)1.64376983
142Intestinal polyposis (HP:0200008)1.64183840
143Hypochromic microcytic anemia (HP:0004840)1.63653966
144Hepatocellular carcinoma (HP:0001402)1.63320722
145Long clavicles (HP:0000890)1.63192107
146Nonimmune hydrops fetalis (HP:0001790)1.63106680
147Abnormality of the acetabulum (HP:0003170)1.63098768
148Cystic hygroma (HP:0000476)1.62937755
149Hypoplasia of the odontoid process (HP:0003311)1.61943588
150Abnormality of mucopolysaccharide metabolism (HP:0011020)1.61438175
151Abnormality of polysaccharide metabolism (HP:0011012)1.61438175
152Abnormality of glycosaminoglycan metabolism (HP:0004371)1.61438175
153Periodontitis (HP:0000704)1.61112011
154Abnormality of the carotid arteries (HP:0005344)1.59426962
155Abnormal tarsal ossification (HP:0008369)1.58985020
156Birth length less than 3rd percentile (HP:0003561)1.58854288
157Spondylolisthesis (HP:0003302)1.58753000
158Broad palm (HP:0001169)1.58514679
159Platyspondyly (HP:0000926)1.57938590
160Curly hair (HP:0002212)1.57288544
161Oral leukoplakia (HP:0002745)1.57100923
162Trismus (HP:0000211)1.56566757
163Coxa valga (HP:0002673)1.56466524
164Hypoplastic pelvis (HP:0008839)1.56222410
165Megaloblastic anemia (HP:0001889)1.55918039
166Neoplasm of the liver (HP:0002896)1.55294353
167Intestinal polyp (HP:0005266)1.55135731
168Freckling (HP:0001480)1.54601198
169Ovarian neoplasm (HP:0100615)1.54575072
170Progressive muscle weakness (HP:0003323)1.54474039
171Neuroblastic tumors (HP:0004376)1.54297489
172Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.54297489
173Primitive neuroectodermal tumor (HP:0030065)1.54297489
174Increased mean platelet volume (HP:0011877)1.54076150
175Abnormality of sulfur amino acid metabolism (HP:0004339)1.53821544
176Unilateral renal agenesis (HP:0000122)1.52662408
177Exostoses (HP:0100777)1.52306807
178Abnormality of the labia majora (HP:0012881)1.52154590
179Long palpebral fissure (HP:0000637)1.51286005
180Abnormal cartilage morphology (HP:0002763)1.51284905
181Abnormal platelet volume (HP:0011876)1.50958470
182Abnormal delayed hypersensitivity skin test (HP:0002963)1.50474832
183Hypochromic anemia (HP:0001931)1.49968831
184Thyroid carcinoma (HP:0002890)1.48653653
185Spastic diplegia (HP:0001264)1.48037606
186Back pain (HP:0003418)1.47282340

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK4.47518036
2PBK2.93852701
3SCYL22.82763434
4EEF2K2.59828784
5FRK2.56054488
6TAOK32.53926117
7CDC72.49921602
8STK162.46421136
9INSRR2.45624823
10EIF2AK32.27222491
11ERN12.22229082
12BRSK22.16633847
13TRIB32.10688236
14PKN22.10467163
15FLT32.06916819
16TSSK61.98468813
17TGFBR11.87339625
18MST41.80346004
19TRIM281.76862748
20VRK21.69214144
21PNCK1.66522806
22EIF2AK11.64210246
23RPS6KA41.60091329
24NEK91.44235343
25ERBB31.44188061
26CHEK21.43530042
27SRPK11.41804465
28ACVR1B1.38578076
29AKT31.37154438
30PLK31.34907494
31TESK11.34785109
32BRD41.34473154
33MAP3K101.33787232
34LATS11.32508963
35CDK121.28311867
36HIPK21.27974832
37LRRK21.25420767
38TAF11.25038424
39PTK61.24726087
40CLK11.24599403
41RPS6KB21.22691896
42TNIK1.20972462
43EIF2AK21.19752655
44BCKDK1.17394251
45ATR1.16944095
46JAK31.16465769
47MAP3K121.13604513
48WEE11.12035882
49MAP3K21.10199018
50VRK11.08858809
51ZAK1.07449811
52CDK61.06290994
53BCR1.05214977
54NME21.01392602
55PIK3CG0.96986779
56PIM20.95736903
57EPHA20.94917353
58MKNK10.94399160
59RPS6KB10.93904815
60TEC0.93490137
61BTK0.91876255
62IRAK30.88232035
63PRKD30.82605653
64MTOR0.81872993
65AURKB0.81867743
66PAK40.80135915
67SIK30.80025361
68SIK10.79457360
69ATM0.79115520
70ALK0.78373244
71NEK20.77803677
72PDGFRA0.76135814
73CDK70.75920926
74RPS6KA20.75904687
75CHEK10.75898626
76ZAP700.75888627
77NME10.74250708
78PDK20.74041395
79MAP3K80.72245301
80PIM10.72215878
81EPHA30.71461803
82CSNK1E0.71123050
83MAP3K30.70860299
84MST1R0.68310119
85NEK10.67893842
86STK40.67855166
87PLK20.67195505
88CDK90.66998117
89MAP2K30.66968951
90PLK40.66792799
91CDK10.66370918
92CDK40.66223516
93ERBB40.66180093
94STK100.65558115
95FER0.62604118
96TTK0.61830422
97CSNK2A10.60207094
98STK30.60003777
99DYRK30.59148667
100FGFR10.58074826
101MET0.57946635
102AURKA0.57919927
103TRPM70.57684873
104BRAF0.57572673
105PLK10.56629033
106CSNK2A20.56529986
107FGFR30.55644909
108CDK20.54467193
109ITK0.53159970
110PTK20.53122390
111CHUK0.52813790
112IRAK40.52269644
113BRSK10.52261272
114BMPR20.52128422
115BUB10.48515624
116LATS20.48225310
117PAK20.47897075
118TESK20.47116408
119CCNB10.46658774
120JAK20.46127447
121MAP3K50.45442452
122FGFR40.45290698
123MAP4K10.45180386
124ILK0.45130782
125MKNK20.44845581
126CDK80.42330984
127PRKCI0.42217653
128PRKDC0.41504327
129CDK190.38841071
130CDK30.38047902
131STK38L0.36861860
132AKT20.36488520
133MAPK140.36344981
134MINK10.35759612
135NUAK10.35522930
136DYRK1B0.34738521
137RPS6KC10.34591928
138KSR10.26815565
139CDK180.25485823
140CDK11A0.25358280
141CDK140.24130124
142BMPR1B0.23855364
143PAK10.23410631

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.63129605
2* Protein export_Homo sapiens_hsa030604.23275114
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.62551040
4One carbon pool by folate_Homo sapiens_hsa006703.31854778
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.88013419
6Selenocompound metabolism_Homo sapiens_hsa004502.64010207
7N-Glycan biosynthesis_Homo sapiens_hsa005102.25991072
8RNA transport_Homo sapiens_hsa030132.19206038
9DNA replication_Homo sapiens_hsa030302.17672793
10Caffeine metabolism_Homo sapiens_hsa002321.98660989
11Sulfur metabolism_Homo sapiens_hsa009201.90704465
12Mismatch repair_Homo sapiens_hsa034301.88739973
13Non-homologous end-joining_Homo sapiens_hsa034501.85707050
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.76707228
15Antigen processing and presentation_Homo sapiens_hsa046121.68530535
16Spliceosome_Homo sapiens_hsa030401.63708122
17Drug metabolism - other enzymes_Homo sapiens_hsa009831.56115826
18Nucleotide excision repair_Homo sapiens_hsa034201.51472545
19Cell cycle_Homo sapiens_hsa041101.51378729
20Thyroid cancer_Homo sapiens_hsa052161.45335242
21Ribosome_Homo sapiens_hsa030101.41457039
22Base excision repair_Homo sapiens_hsa034101.40833162
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.38169091
24Oxidative phosphorylation_Homo sapiens_hsa001901.27632717
25Type I diabetes mellitus_Homo sapiens_hsa049401.27222431
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26720584
27Parkinsons disease_Homo sapiens_hsa050121.26013233
28Propanoate metabolism_Homo sapiens_hsa006401.18563023
29RNA degradation_Homo sapiens_hsa030181.18172783
30mRNA surveillance pathway_Homo sapiens_hsa030151.17310194
31Proteasome_Homo sapiens_hsa030501.17132714
32p53 signaling pathway_Homo sapiens_hsa041151.16543331
33Pyrimidine metabolism_Homo sapiens_hsa002401.15056497
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13366791
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12858077
36Huntingtons disease_Homo sapiens_hsa050161.06853362
37Carbon metabolism_Homo sapiens_hsa012001.06288695
38Tryptophan metabolism_Homo sapiens_hsa003801.05644335
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05536741
40Galactose metabolism_Homo sapiens_hsa000521.05492763
41Folate biosynthesis_Homo sapiens_hsa007901.04406823
42Lysine degradation_Homo sapiens_hsa003101.00033626
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98763803
44Legionellosis_Homo sapiens_hsa051340.96723978
45Bladder cancer_Homo sapiens_hsa052190.94425773
46Steroid biosynthesis_Homo sapiens_hsa001000.94064804
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92316449
48Homologous recombination_Homo sapiens_hsa034400.90855904
49Oocyte meiosis_Homo sapiens_hsa041140.89346285
50RNA polymerase_Homo sapiens_hsa030200.88689592
51Viral carcinogenesis_Homo sapiens_hsa052030.88667121
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.85310676
53Vibrio cholerae infection_Homo sapiens_hsa051100.81442255
54Prostate cancer_Homo sapiens_hsa052150.80992478
55Chronic myeloid leukemia_Homo sapiens_hsa052200.79030519
56Fatty acid elongation_Homo sapiens_hsa000620.77669715
57Phenylalanine metabolism_Homo sapiens_hsa003600.73987741
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73092489
59Other glycan degradation_Homo sapiens_hsa005110.72844847
60Starch and sucrose metabolism_Homo sapiens_hsa005000.71596244
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70397781
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70019458
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.69952927
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69839611
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69075446
66Tyrosine metabolism_Homo sapiens_hsa003500.66642763
67Epstein-Barr virus infection_Homo sapiens_hsa051690.64988817
68Insulin resistance_Homo sapiens_hsa049310.64241513
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64141201
70Alzheimers disease_Homo sapiens_hsa050100.61929882
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.60775980
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60531919
73Glutathione metabolism_Homo sapiens_hsa004800.59208114
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58972992
75Renin-angiotensin system_Homo sapiens_hsa046140.58671242
76Hepatitis B_Homo sapiens_hsa051610.55951761
77Biosynthesis of amino acids_Homo sapiens_hsa012300.55417850
78Glucagon signaling pathway_Homo sapiens_hsa049220.54230970
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54073806
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53910064
81Pentose phosphate pathway_Homo sapiens_hsa000300.53741339
82Basal transcription factors_Homo sapiens_hsa030220.53304328
83Prolactin signaling pathway_Homo sapiens_hsa049170.53225259
84MicroRNAs in cancer_Homo sapiens_hsa052060.53053935
85Herpes simplex infection_Homo sapiens_hsa051680.52067067
86mTOR signaling pathway_Homo sapiens_hsa041500.51129064
87Endometrial cancer_Homo sapiens_hsa052130.50832420
88HTLV-I infection_Homo sapiens_hsa051660.50583285
89Thyroid hormone synthesis_Homo sapiens_hsa049180.50312385
90Adherens junction_Homo sapiens_hsa045200.50097876
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.49211229
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.48255595
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47001167
94Non-small cell lung cancer_Homo sapiens_hsa052230.46663448
95Small cell lung cancer_Homo sapiens_hsa052220.45702491
96Vitamin B6 metabolism_Homo sapiens_hsa007500.45469863
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45462073
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44928637
99Pancreatic cancer_Homo sapiens_hsa052120.44468731
100Metabolic pathways_Homo sapiens_hsa011000.41312827
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40807532
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40655515
103Hippo signaling pathway_Homo sapiens_hsa043900.40439492
104Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40426438
105Acute myeloid leukemia_Homo sapiens_hsa052210.39939087
106Measles_Homo sapiens_hsa051620.39739782
107Wnt signaling pathway_Homo sapiens_hsa043100.39359927
108Colorectal cancer_Homo sapiens_hsa052100.36605683
109TGF-beta signaling pathway_Homo sapiens_hsa043500.36087783
110Systemic lupus erythematosus_Homo sapiens_hsa053220.36009074
111Complement and coagulation cascades_Homo sapiens_hsa046100.35059691
112FoxO signaling pathway_Homo sapiens_hsa040680.34982804
113Purine metabolism_Homo sapiens_hsa002300.32865724
114Apoptosis_Homo sapiens_hsa042100.31590894
115Pyruvate metabolism_Homo sapiens_hsa006200.31571674
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31280595
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31241846
118Fanconi anemia pathway_Homo sapiens_hsa034600.30751063
119Chemical carcinogenesis_Homo sapiens_hsa052040.29748059
120Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28941910
121Basal cell carcinoma_Homo sapiens_hsa052170.28555788
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.28123553
123Shigellosis_Homo sapiens_hsa051310.21988306
124Melanoma_Homo sapiens_hsa052180.21848273
125Fatty acid metabolism_Homo sapiens_hsa012120.21386740
126Hedgehog signaling pathway_Homo sapiens_hsa043400.19111957
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18425186
128Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.15286425
129Renal cell carcinoma_Homo sapiens_hsa052110.14592069
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.13469477
131Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.13185752
132Pathways in cancer_Homo sapiens_hsa052000.11798783
133Proteoglycans in cancer_Homo sapiens_hsa052050.07292585
134Arginine and proline metabolism_Homo sapiens_hsa003300.05718287
135HIF-1 signaling pathway_Homo sapiens_hsa040660.01977255
136Butanoate metabolism_Homo sapiens_hsa006500.01676879

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