SRP72P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)6.42674024
2chaperone-mediated protein transport (GO:0072321)6.19500272
3cell wall macromolecule metabolic process (GO:0044036)5.43157787
4establishment of protein localization to mitochondrial membrane (GO:0090151)5.35343391
5protein prenylation (GO:0018342)4.96367048
6prenylation (GO:0097354)4.96367048
7neuron fate determination (GO:0048664)4.75744533
8positive regulation by symbiont of host defense response (GO:0052509)4.13861186
9modulation by symbiont of host defense response (GO:0052031)4.13861186
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.13861186
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.13861186
12positive regulation by organism of defense response of other organism involved in symbiotic interact4.13861186
13modulation by symbiont of host immune response (GO:0052553)4.13861186
14detection of molecule of bacterial origin (GO:0032490)4.11289009
15ATP synthesis coupled proton transport (GO:0015986)4.06669477
16energy coupled proton transport, down electrochemical gradient (GO:0015985)4.06669477
17proteasome assembly (GO:0043248)3.89088898
18microglial cell activation (GO:0001774)3.69037563
19DNA damage response, detection of DNA damage (GO:0042769)3.56500257
20DNA deamination (GO:0045006)3.54275841
21response to acidic pH (GO:0010447)3.39630716
22negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.38557142
23negative regulation of T-helper cell differentiation (GO:0045623)3.38557142
24response to pheromone (GO:0019236)3.31499977
25cytokine production involved in immune response (GO:0002367)3.29955635
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.29701207
27indolalkylamine catabolic process (GO:0046218)3.28440690
28tryptophan catabolic process (GO:0006569)3.28440690
29indole-containing compound catabolic process (GO:0042436)3.28440690
30production of molecular mediator of immune response (GO:0002440)3.24512850
31respiratory chain complex IV assembly (GO:0008535)3.20065218
32viral transcription (GO:0019083)3.18885184
33regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.17065968
34sympathetic nervous system development (GO:0048485)3.14656254
35exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.11961709
36positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.11206828
37hypothalamus development (GO:0021854)3.08795432
38GTP biosynthetic process (GO:0006183)3.08559981
39response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.07330884
40response to host immune response (GO:0052572)3.07330884
41translational termination (GO:0006415)3.05474301
42limb bud formation (GO:0060174)3.03521009
43heparin biosynthetic process (GO:0030210)3.03470148
44heparin metabolic process (GO:0030202)3.03470148
45negative regulation of growth of symbiont in host (GO:0044130)3.02408493
46negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.02408493
47modulation of growth of symbiont involved in interaction with host (GO:0044144)3.02408493
48regulation of growth of symbiont in host (GO:0044126)3.02408493
49positive regulation of interleukin-1 beta secretion (GO:0050718)3.02365249
50neuron fate specification (GO:0048665)2.99448283
51behavioral response to nicotine (GO:0035095)2.97682087
52water-soluble vitamin biosynthetic process (GO:0042364)2.96030603
53nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.86959659
54regulation of germinal center formation (GO:0002634)2.85986022
55innate immune response in mucosa (GO:0002227)2.84308904
56positive regulation of interleukin-1 secretion (GO:0050716)2.82564959
57mitochondrial respiratory chain complex I assembly (GO:0032981)2.82162556
58NADH dehydrogenase complex assembly (GO:0010257)2.82162556
59mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.82162556
60microtubule polymerization or depolymerization (GO:0031109)2.79622573
61cardiac ventricle formation (GO:0003211)2.78732872
62SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.74022861
63cGMP biosynthetic process (GO:0006182)2.73140233
64cotranslational protein targeting to membrane (GO:0006613)2.72998944
65protein complex biogenesis (GO:0070271)2.72607206
66UTP metabolic process (GO:0046051)2.71672756
67male sex determination (GO:0030238)2.71006208
68regulation of interleukin-1 beta secretion (GO:0050706)2.68258978
69protein targeting to ER (GO:0045047)2.68140807
70endoderm formation (GO:0001706)2.67211868
71cytochrome complex assembly (GO:0017004)2.66366479
72lens fiber cell development (GO:0070307)2.66237681
73electron transport chain (GO:0022900)2.65515452
74transcription elongation from RNA polymerase III promoter (GO:0006385)2.65250860
75termination of RNA polymerase III transcription (GO:0006386)2.65250860
76establishment of protein localization to endoplasmic reticulum (GO:0072599)2.65015874
77tryptophan metabolic process (GO:0006568)2.62962905
78respiratory electron transport chain (GO:0022904)2.62197571
79regulation of isotype switching to IgG isotypes (GO:0048302)2.60976565
80forebrain neuron differentiation (GO:0021879)2.60760806
81positive regulation of toll-like receptor signaling pathway (GO:0034123)2.60559724
82translational elongation (GO:0006414)2.60215272
83positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.59374663
84protein targeting to Golgi (GO:0000042)2.57207792
85response to host (GO:0075136)2.55769142
86response to host defenses (GO:0052200)2.55769142
87response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.55769142
88ubiquinone biosynthetic process (GO:0006744)2.55323167
89indolalkylamine metabolic process (GO:0006586)2.54503044
90kidney morphogenesis (GO:0060993)2.54421013
91cellular response to pH (GO:0071467)2.54235366
92positive regulation of type 2 immune response (GO:0002830)2.52803093
93cardiac chamber formation (GO:0003207)2.52572088
94protein localization to endoplasmic reticulum (GO:0070972)2.51743520
95negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.50110425
96substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.49345262
97substrate-independent telencephalic tangential migration (GO:0021826)2.49345262
98purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.48946257
99sequestering of actin monomers (GO:0042989)2.48724935
100negative regulation of alpha-beta T cell differentiation (GO:0046639)2.48499736

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.42629967
2TAF15_26573619_Chip-Seq_HEK293_Human3.55741691
3EZH2_22144423_ChIP-Seq_EOC_Human3.52705717
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.27480873
5VDR_22108803_ChIP-Seq_LS180_Human2.90357730
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.80226201
7CBX2_27304074_Chip-Seq_ESCs_Mouse2.64758801
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.50147562
9EWS_26573619_Chip-Seq_HEK293_Human2.39519076
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.37723558
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21543973
12P300_19829295_ChIP-Seq_ESCs_Human2.15695211
13ZNF274_21170338_ChIP-Seq_K562_Hela2.15495864
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.15234090
15IGF1R_20145208_ChIP-Seq_DFB_Human2.14496061
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.11767698
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.08974573
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.98306768
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.93003763
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.90792609
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.90545146
22RBPJ_22232070_ChIP-Seq_NCS_Mouse1.88102862
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86856248
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.86563191
25FUS_26573619_Chip-Seq_HEK293_Human1.85207288
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84817452
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76892884
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74735290
29HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.74535543
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73685069
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.68125040
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.64464102
33CBP_20019798_ChIP-Seq_JUKART_Human1.64464102
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.63697157
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.61113646
36SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56167554
37TCF4_22108803_ChIP-Seq_LS180_Human1.53315743
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44641269
39RNF2_27304074_Chip-Seq_NSC_Mouse1.42921589
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42466901
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42101483
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.41448951
43ER_23166858_ChIP-Seq_MCF-7_Human1.38483647
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35494412
45GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.34519081
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33182986
47REST_21632747_ChIP-Seq_MESCs_Mouse1.32594908
48GBX2_23144817_ChIP-Seq_PC3_Human1.32501174
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.31990592
50KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.31694836
51KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.31694836
52KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.31694836
53SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.31345965
54VDR_23849224_ChIP-Seq_CD4+_Human1.31303404
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30736495
56JARID2_20064375_ChIP-Seq_MESCs_Mouse1.28233147
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27940113
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27940113
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26041711
60SOX2_19829295_ChIP-Seq_ESCs_Human1.25879187
61NANOG_19829295_ChIP-Seq_ESCs_Human1.25879187
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25796860
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25665662
64TP53_22573176_ChIP-Seq_HFKS_Human1.23574267
65FLI1_21867929_ChIP-Seq_TH2_Mouse1.23434325
66SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19449638
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18319493
68SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18001643
69RUNX2_22187159_ChIP-Seq_PCA_Human1.13982921
70ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13265016
71SMAD4_21799915_ChIP-Seq_A2780_Human1.10395185
72SOX9_26525672_Chip-Seq_HEART_Mouse1.08955420
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06706434
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05243885
75TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04942535
76FLI1_27457419_Chip-Seq_LIVER_Mouse1.04685779
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04005144
78FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03714363
79FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03316446
80JUN_21703547_ChIP-Seq_K562_Human1.02761163
81P53_22387025_ChIP-Seq_ESCs_Mouse1.01496515
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01109147
83BCAT_22108803_ChIP-Seq_LS180_Human1.00590387
84KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00052866
85AR_25329375_ChIP-Seq_VCAP_Human0.99877353
86NANOG_18555785_Chip-Seq_ESCs_Mouse0.96935404
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96419481
88FOXH1_21741376_ChIP-Seq_EPCs_Human0.96058574
89EZH2_27294783_Chip-Seq_ESCs_Mouse0.95800609
90RNF2_18974828_ChIP-Seq_MESCs_Mouse0.95671832
91EZH2_18974828_ChIP-Seq_MESCs_Mouse0.95671832
92SMAD3_21741376_ChIP-Seq_ESCs_Human0.93664233
93JARID2_20075857_ChIP-Seq_MESCs_Mouse0.93618072
94PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93431512
95ETV1_20927104_ChIP-Seq_GIST48_Human0.92751629
96RBPJ_21746931_ChIP-Seq_IB4_Human0.92563376
97RNF2_27304074_Chip-Seq_ESCs_Mouse0.89432546
98TP63_19390658_ChIP-ChIP_HaCaT_Human0.89243440
99TTF2_22483619_ChIP-Seq_HELA_Human0.88768758
100NCOR_22424771_ChIP-Seq_293T_Human0.88408712

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism5.76794818
2MP0003787_abnormal_imprinting5.48482674
3MP0003880_abnormal_central_pattern5.19034304
4MP0009379_abnormal_foot_pigmentation3.97292109
5MP0002163_abnormal_gland_morphology2.86335615
6MP0006276_abnormal_autonomic_nervous2.72170897
7MP0003121_genomic_imprinting2.34259035
8MP0004142_abnormal_muscle_tone2.25142762
9MP0001348_abnormal_lacrimal_gland2.09310404
10MP0002876_abnormal_thyroid_physiology2.05651463
11MP0004145_abnormal_muscle_electrophysio1.96962225
12MP0005423_abnormal_somatic_nervous1.90877200
13MP0008875_abnormal_xenobiotic_pharmacok1.87580720
14MP0001835_abnormal_antigen_presentation1.83279608
15MP0002138_abnormal_hepatobiliary_system1.82790683
16MP0000372_irregular_coat_pigmentation1.78236819
17MP0005379_endocrine/exocrine_gland_phen1.77172247
18MP0009046_muscle_twitch1.68682786
19MP0004885_abnormal_endolymph1.63821702
20MP0009780_abnormal_chondrocyte_physiolo1.63561094
21MP0002277_abnormal_respiratory_mucosa1.55004554
22MP0006292_abnormal_olfactory_placode1.51985925
23MP0008872_abnormal_physiological_respon1.49876947
24MP0008058_abnormal_DNA_repair1.46489254
25MP0003724_increased_susceptibility_to1.44936322
26MP0009764_decreased_sensitivity_to1.35760119
27MP0002272_abnormal_nervous_system1.34345973
28MP0004742_abnormal_vestibular_system1.34236593
29MP0003123_paternal_imprinting1.32656973
30MP0000685_abnormal_immune_system1.29189859
31MP0001986_abnormal_taste_sensitivity1.27899850
32MP0008877_abnormal_DNA_methylation1.26110326
33MP0004381_abnormal_hair_follicle1.26075448
34MP0003122_maternal_imprinting1.19308667
35MP0001968_abnormal_touch/_nociception1.17399340
36MP0004924_abnormal_behavior1.16824903
37MP0005386_behavior/neurological_phenoty1.16824903
38MP0005084_abnormal_gallbladder_morpholo1.16662912
39MP0000955_abnormal_spinal_cord1.13887106
40MP0002751_abnormal_autonomic_nervous1.11906271
41MP0005551_abnormal_eye_electrophysiolog1.11606352
42MP0000569_abnormal_digit_pigmentation1.11090837
43MP0009745_abnormal_behavioral_response1.11020957
44MP0001485_abnormal_pinna_reflex1.10034090
45MP0000778_abnormal_nervous_system1.09543345
46MP0001764_abnormal_homeostasis1.09507560
47MP0001188_hyperpigmentation1.06624015
48MP0005174_abnormal_tail_pigmentation1.06315786
49MP0001800_abnormal_humoral_immune1.03859938
50MP0003646_muscle_fatigue1.02642477
51MP0005671_abnormal_response_to0.98877141
52MP0005187_abnormal_penis_morphology0.98756460
53MP0001529_abnormal_vocalization0.98505965
54MP0002234_abnormal_pharynx_morphology0.98410289
55MP0003959_abnormal_lean_body0.97476347
56MP0010030_abnormal_orbit_morphology0.97151397
57MP0001873_stomach_inflammation0.96278669
58MP0000631_abnormal_neuroendocrine_gland0.95404504
59MP0009785_altered_susceptibility_to0.95289563
60MP0003011_delayed_dark_adaptation0.94991119
61MP0003718_maternal_effect0.89889107
62MP0002184_abnormal_innervation0.89065470
63MP0002928_abnormal_bile_duct0.88108082
64MP0005377_hearing/vestibular/ear_phenot0.87079862
65MP0003878_abnormal_ear_physiology0.87079862
66MP0003879_abnormal_hair_cell0.84485863
67MP0002282_abnormal_trachea_morphology0.83834403
68MP0000026_abnormal_inner_ear0.82584564
69MP0003252_abnormal_bile_duct0.79919002
70MP0003172_abnormal_lysosome_physiology0.79065196
71MP0005645_abnormal_hypothalamus_physiol0.77702421
72MP0001970_abnormal_pain_threshold0.77186577
73MP0003195_calcinosis0.76890473
74MP0001919_abnormal_reproductive_system0.76510850
75MP0002064_seizures0.76404265
76MP0010155_abnormal_intestine_physiology0.76380987
77MP0006072_abnormal_retinal_apoptosis0.74429125
78MP0003136_yellow_coat_color0.73966384
79MP0003635_abnormal_synaptic_transmissio0.72158306
80MP0004147_increased_porphyrin_level0.71845223
81MP0002733_abnormal_thermal_nociception0.71814084
82MP0002752_abnormal_somatic_nervous0.71809050
83MP0005085_abnormal_gallbladder_physiolo0.71499562
84MP0005387_immune_system_phenotype0.71221932
85MP0001790_abnormal_immune_system0.71221932
86MP0001879_abnormal_lymphatic_vessel0.71091463
87MP0002148_abnormal_hypersensitivity_rea0.70281116
88MP0002653_abnormal_ependyma_morphology0.68111053
89MP0004133_heterotaxia0.67740889
90MP0008873_increased_physiological_sensi0.67391139
91MP0005253_abnormal_eye_physiology0.67237433
92MP0001486_abnormal_startle_reflex0.66560611
93MP0000749_muscle_degeneration0.66112164
94MP0009765_abnormal_xenobiotic_induced0.65377516
95MP0002229_neurodegeneration0.65265023
96MP0001963_abnormal_hearing_physiology0.64484772
97MP0003638_abnormal_response/metabolism_0.64240661
98MP0002882_abnormal_neuron_morphology0.62980325
99MP0005389_reproductive_system_phenotype0.62459884
100MP0000049_abnormal_middle_ear0.62358192

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)5.86139181
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.86139181
3Carpal bone hypoplasia (HP:0001498)4.02484521
43-Methylglutaconic aciduria (HP:0003535)3.76900760
5Abnormality of the phalanges of the 2nd finger (HP:0009541)3.60650116
6Abnormal respiratory motile cilium morphology (HP:0005938)3.58242786
7Abnormal respiratory epithelium morphology (HP:0012253)3.58242786
8Increased hepatocellular lipid droplets (HP:0006565)3.48176850
9Diastasis recti (HP:0001540)3.39576791
10Abnormal ciliary motility (HP:0012262)3.20654850
11Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.19588577
12Reticulocytopenia (HP:0001896)3.17101406
13Absent rod-and cone-mediated responses on ERG (HP:0007688)3.13336978
14Stenosis of the external auditory canal (HP:0000402)3.09127414
15Abnormality of the 2nd finger (HP:0004100)3.08889408
16Myokymia (HP:0002411)3.05731882
17Abnormality of the phalanges of the 5th finger (HP:0004213)2.99559388
18Pancreatic fibrosis (HP:0100732)2.96001253
19Disproportionate short-trunk short stature (HP:0003521)2.92847543
20Lipid accumulation in hepatocytes (HP:0006561)2.89893369
21Optic neuritis (HP:0100653)2.85134458
22Retrobulbar optic neuritis (HP:0100654)2.85134458
23Abnormal rod and cone electroretinograms (HP:0008323)2.71817547
24Mitochondrial inheritance (HP:0001427)2.70786581
25Exertional dyspnea (HP:0002875)2.62982105
26Abnormality of DNA repair (HP:0003254)2.61822938
27Chronic hepatic failure (HP:0100626)2.61781950
28Type II lissencephaly (HP:0007260)2.56811710
29Increased CSF lactate (HP:0002490)2.56493907
30Renal Fanconi syndrome (HP:0001994)2.51625698
31Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.48909022
32Pancreatic cysts (HP:0001737)2.48155981
33Hepatocellular necrosis (HP:0001404)2.45786080
34True hermaphroditism (HP:0010459)2.44723025
35Inability to walk (HP:0002540)2.40856679
36Thoracolumbar scoliosis (HP:0002944)2.39840803
37Choroideremia (HP:0001139)2.39176306
38Hepatic necrosis (HP:0002605)2.39043859
39Orchitis (HP:0100796)2.38883708
40Aplasia/Hypoplasia of the scapulae (HP:0006713)2.35663864
41Hypoplastic scapulae (HP:0000882)2.35663864
42Chronic sinusitis (HP:0011109)2.35449661
43Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.33770201
44Abnormal respiratory motile cilium physiology (HP:0012261)2.33272880
45Symphalangism affecting the phalanges of the hand (HP:0009773)2.32641138
46Attenuation of retinal blood vessels (HP:0007843)2.28671381
47Occipital encephalocele (HP:0002085)2.25373982
48Chronic otitis media (HP:0000389)2.23996226
49Broad alveolar ridges (HP:0000187)2.23786457
50Barrel-shaped chest (HP:0001552)2.21443327
51Thyroid-stimulating hormone excess (HP:0002925)2.20621832
52Acute necrotizing encephalopathy (HP:0006965)2.18276785
53Muscle fiber splitting (HP:0003555)2.17082360
54Adactyly (HP:0009776)2.16103933
55Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.15954939
56Abnormality of midbrain morphology (HP:0002418)2.11799833
57Molar tooth sign on MRI (HP:0002419)2.11799833
58Increased serum lactate (HP:0002151)2.10362626
59Congenital, generalized hypertrichosis (HP:0004540)2.08581330
60Entropion (HP:0000621)2.04236542
61Constricted visual fields (HP:0001133)2.03089365
62Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.01223687
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.00338701
64Abnormality of alanine metabolism (HP:0010916)2.00338701
65Hyperalaninemia (HP:0003348)2.00338701
66Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.99962659
67Keratoconjunctivitis (HP:0001096)1.97623690
68Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.97008090
69Pachygyria (HP:0001302)1.96988818
70Amaurosis fugax (HP:0100576)1.96190766
71Keratoconjunctivitis sicca (HP:0001097)1.93448562
72Agitation (HP:0000713)1.93137374
73Decreased activity of mitochondrial respiratory chain (HP:0008972)1.89400971
74Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.89400971
75Type 2 muscle fiber atrophy (HP:0003554)1.88911329
76Abnormality of urine glucose concentration (HP:0011016)1.87616280
77Glycosuria (HP:0003076)1.87616280
78Hypoproteinemia (HP:0003075)1.86924406
79Abnormality of renal resorption (HP:0011038)1.86896319
80Increased intramyocellular lipid droplets (HP:0012240)1.86597796
81Respiratory difficulties (HP:0002880)1.86559539
82Progressive macrocephaly (HP:0004481)1.86431189
83Leukodystrophy (HP:0002415)1.86169376
84Hypochromic microcytic anemia (HP:0004840)1.84728076
85Myositis (HP:0100614)1.83591299
86Bony spicule pigmentary retinopathy (HP:0007737)1.82260141
87Lissencephaly (HP:0001339)1.81683316
88Furrowed tongue (HP:0000221)1.80736404
89Optic disc pallor (HP:0000543)1.77080020
90Anophthalmia (HP:0000528)1.77000767
91Short clavicles (HP:0000894)1.76547712
92Abnormality of magnesium homeostasis (HP:0004921)1.75911406
93Abnormal foot bone ossification (HP:0010675)1.75538425
94Mesomelia (HP:0003027)1.75116992
95Delayed CNS myelination (HP:0002188)1.75054826
96Short middle phalanx of the 5th finger (HP:0004220)1.74272462
97Retinal dysplasia (HP:0007973)1.72617217
98Macrocytic anemia (HP:0001972)1.72350276
99Congenital stationary night blindness (HP:0007642)1.71554963
100Radial bowing (HP:0002986)1.71328400

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR6.63999997
2TNIK4.32383465
3STK164.06157193
4TIE13.89151980
5EPHA43.81202940
6CDK82.34673469
7WNK42.14576639
8MAP3K122.11513258
9BUB12.05796779
10TRIM281.90122162
11TLK11.86128313
12IRAK41.74865276
13FRK1.72560210
14MINK11.66315721
15NUAK11.66186294
16BMPR1B1.60787557
17MAP4K21.57154500
18EIF2AK31.55531721
19EPHA31.52515329
20CCNB11.50975934
21CASK1.50169951
22STK38L1.48257670
23PINK11.47309843
24MAP3K91.44871209
25GRK11.31689218
26OXSR11.29621205
27ADRBK21.29205358
28CDK191.29136892
29EIF2AK11.23698362
30BMPR21.18934857
31MKNK21.18171311
32IRAK11.16106896
33TEC1.12717357
34WNK31.06716153
35NTRK21.01157134
36IRAK21.00492894
37VRK10.99020118
38PKN10.98512103
39DYRK20.96449181
40PHKG10.88755772
41PHKG20.88755772
42TGFBR10.87129982
43MKNK10.85527879
44FGFR20.84794768
45PAK30.79201881
46MARK10.73735737
47ADRBK10.72746075
48BLK0.71335602
49PLK30.64579977
50DAPK20.64316779
51STK390.63479965
52ITK0.63420119
53PNCK0.61925324
54SCYL20.61641572
55PRKG10.54663049
56NLK0.54402793
57TGFBR20.50681381
58DYRK30.50351347
59RAF10.49331998
60MAPK130.49189985
61GRK60.47272352
62MAPK150.42467583
63IKBKB0.41278292
64RPS6KA40.41008151
65ERBB30.40946583
66FGR0.40629840
67NEK60.40357717
68BTK0.39081737
69SRPK10.38588023
70PRKCG0.38513255
71RPS6KA50.38406327
72WNK10.38146747
73MARK30.36862291
74CSF1R0.36575419
75KIT0.35284424
76TAOK30.32520758
77MATK0.31733627
78CAMK1G0.29883234
79DMPK0.28833980
80EGFR0.28593332
81PRKCQ0.26877410
82PDK20.26850514
83KDR0.26661770
84DAPK30.26543430
85CDK140.25571570
86CSNK1G30.25361437
87RPS6KA10.25064913
88CDC70.24891429
89ARAF0.24231425
90SGK10.23954286
91EPHB20.23315506
92BCR0.23110557
93PBK0.22396518
94CDK30.22171700
95CSNK1G10.21559317
96MAP3K110.20544139
97SYK0.20543158
98ILK0.20278607
99MST40.20214197
100ROCK10.20091146

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.23674555
2Oxidative phosphorylation_Homo sapiens_hsa001903.70151670
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.67441754
4Ribosome_Homo sapiens_hsa030103.45910488
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.42160768
6Allograft rejection_Homo sapiens_hsa053303.40466322
7Autoimmune thyroid disease_Homo sapiens_hsa053203.33588749
8Parkinsons disease_Homo sapiens_hsa050123.06356561
9Cardiac muscle contraction_Homo sapiens_hsa042602.85982132
10Protein export_Homo sapiens_hsa030602.60611288
11Phototransduction_Homo sapiens_hsa047442.20995340
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.12510598
13Graft-versus-host disease_Homo sapiens_hsa053322.06116957
14Huntingtons disease_Homo sapiens_hsa050162.06112822
15Alzheimers disease_Homo sapiens_hsa050101.90143283
16Type I diabetes mellitus_Homo sapiens_hsa049401.85969302
17Rheumatoid arthritis_Homo sapiens_hsa053231.68126039
18Proteasome_Homo sapiens_hsa030501.65503871
19Nicotine addiction_Homo sapiens_hsa050331.62900268
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54237537
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.49121829
22Systemic lupus erythematosus_Homo sapiens_hsa053221.46750436
23Linoleic acid metabolism_Homo sapiens_hsa005911.41586647
24RNA degradation_Homo sapiens_hsa030181.37128521
25Collecting duct acid secretion_Homo sapiens_hsa049661.33335496
26Fanconi anemia pathway_Homo sapiens_hsa034601.30332011
27RNA polymerase_Homo sapiens_hsa030201.29732613
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.29192955
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25348979
30Tryptophan metabolism_Homo sapiens_hsa003801.19239849
31Staphylococcus aureus infection_Homo sapiens_hsa051501.15908428
32Basal transcription factors_Homo sapiens_hsa030221.14473141
33Leishmaniasis_Homo sapiens_hsa051401.06486608
34Ether lipid metabolism_Homo sapiens_hsa005651.06426359
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98154521
36Propanoate metabolism_Homo sapiens_hsa006400.96631567
37Homologous recombination_Homo sapiens_hsa034400.96368707
38Cocaine addiction_Homo sapiens_hsa050300.87357332
39Morphine addiction_Homo sapiens_hsa050320.86367981
40Viral myocarditis_Homo sapiens_hsa054160.86039178
41beta-Alanine metabolism_Homo sapiens_hsa004100.84716950
42Serotonergic synapse_Homo sapiens_hsa047260.84056958
43Nucleotide excision repair_Homo sapiens_hsa034200.83280056
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81256127
45Non-homologous end-joining_Homo sapiens_hsa034500.80795170
46Antigen processing and presentation_Homo sapiens_hsa046120.79475449
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73755029
48Fat digestion and absorption_Homo sapiens_hsa049750.71013293
49Taste transduction_Homo sapiens_hsa047420.67008641
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.66525129
51Dorso-ventral axis formation_Homo sapiens_hsa043200.65419414
52Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.65260755
53GABAergic synapse_Homo sapiens_hsa047270.64188877
54Alcoholism_Homo sapiens_hsa050340.63060816
55Hematopoietic cell lineage_Homo sapiens_hsa046400.62830821
56Axon guidance_Homo sapiens_hsa043600.62574937
57Butanoate metabolism_Homo sapiens_hsa006500.62298450
58Insulin secretion_Homo sapiens_hsa049110.59020704
59Olfactory transduction_Homo sapiens_hsa047400.58707986
60T cell receptor signaling pathway_Homo sapiens_hsa046600.58002015
61Vitamin digestion and absorption_Homo sapiens_hsa049770.57372776
62Synaptic vesicle cycle_Homo sapiens_hsa047210.56545976
63Pyrimidine metabolism_Homo sapiens_hsa002400.55859444
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53215758
65Folate biosynthesis_Homo sapiens_hsa007900.53161347
66Amphetamine addiction_Homo sapiens_hsa050310.51586365
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50570584
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49709315
69Tuberculosis_Homo sapiens_hsa051520.49488607
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.48625571
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48474551
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47795189
73Glutamatergic synapse_Homo sapiens_hsa047240.47707899
74RNA transport_Homo sapiens_hsa030130.46078300
75Arachidonic acid metabolism_Homo sapiens_hsa005900.41639049
76Retinol metabolism_Homo sapiens_hsa008300.40446286
77Mismatch repair_Homo sapiens_hsa034300.39948877
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39715268
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39086782
80TGF-beta signaling pathway_Homo sapiens_hsa043500.38664628
81Spliceosome_Homo sapiens_hsa030400.37821043
82Circadian entrainment_Homo sapiens_hsa047130.37474750
83Dopaminergic synapse_Homo sapiens_hsa047280.34504660
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34340443
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33461985
86Purine metabolism_Homo sapiens_hsa002300.33228618
87Oxytocin signaling pathway_Homo sapiens_hsa049210.31167899
88Caffeine metabolism_Homo sapiens_hsa002320.27916870
89Phagosome_Homo sapiens_hsa041450.27461953
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22822251
91Chemical carcinogenesis_Homo sapiens_hsa052040.22674841
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.22504125
93Long-term depression_Homo sapiens_hsa047300.21775764
94Cholinergic synapse_Homo sapiens_hsa047250.21617748
95cAMP signaling pathway_Homo sapiens_hsa040240.20773173
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.18784948
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.18781887
98African trypanosomiasis_Homo sapiens_hsa051430.17856284
99Metabolic pathways_Homo sapiens_hsa011000.17160828
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.16590927

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