ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	5.26129206
2	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	4.53558822
3	negative regulation of translation, ncRNA-mediated (GO:0040033)	4.53558822
4	regulation of translation, ncRNA-mediated (GO:0045974)	4.53558822
5	behavioral response to nicotine (GO:0035095)	3.95319928
6	DNA double-strand break processing (GO:0000729)	3.91513953
7	replication fork processing (GO:0031297)	3.85375036
8	proteasome assembly (GO:0043248)	3.66896297
9	otic vesicle formation (GO:0030916)	3.66692444
10	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.58438154
11	hindbrain development (GO:0030902)	3.49536712
12	cytoplasmic mRNA processing body assembly (GO:0033962)	3.47812005
13	intraciliary transport (GO:0042073)	3.39684726
14	neural tube formation (GO:0001841)	3.37709057
15	respiratory chain complex IV assembly (GO:0008535)	3.27823160
16	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.23761808
17	single strand break repair (GO:0000012)	3.19144816
18	protein neddylation (GO:0045116)	3.17234103
19	limb bud formation (GO:0060174)	3.13624736
20	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.13301900
21	protein prenylation (GO:0018342)	3.12332700
22	prenylation (GO:0097354)	3.12332700
23	epithelial cilium movement (GO:0003351)	3.10517978
24	pre-miRNA processing (GO:0031054)	3.10087194
25	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.09160478
26	regulation of centriole replication (GO:0046599)	3.08357505
27	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.07236704
28	microtubule anchoring (GO:0034453)	3.07165552
29	dendritic spine morphogenesis (GO:0060997)	3.03810743
30	presynaptic membrane assembly (GO:0097105)	3.03721889
31	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.00083253
32	recombinational repair (GO:0000725)	2.99452445
33	double-strand break repair via homologous recombination (GO:0000724)	2.97303794
34	rRNA catabolic process (GO:0016075)	2.95422501
35	nephron tubule morphogenesis (GO:0072078)	2.93734718
36	nephron epithelium morphogenesis (GO:0072088)	2.93734718
37	regulation of action potential (GO:0098900)	2.92402728
38	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.89748369
39	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.89748369
40	NADH dehydrogenase complex assembly (GO:0010257)	2.89748369
41	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.88051777
42	keratinocyte development (GO:0003334)	2.86700995
43	forebrain morphogenesis (GO:0048853)	2.85818457
44	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.83178795
45	regulation of mitotic spindle checkpoint (GO:1903504)	2.83178795
46	detection of light stimulus involved in sensory perception (GO:0050962)	2.82084966
47	detection of light stimulus involved in visual perception (GO:0050908)	2.82084966
48	regulation of centrosome cycle (GO:0046605)	2.82020009
49	DNA deamination (GO:0045006)	2.79063879
50	olfactory bulb development (GO:0021772)	2.77302820
51	somite rostral/caudal axis specification (GO:0032525)	2.74654206
52	seminiferous tubule development (GO:0072520)	2.70685299
53	histone mRNA catabolic process (GO:0071044)	2.69993826
54	renal tubule morphogenesis (GO:0061333)	2.69291197
55	retinal cone cell development (GO:0046549)	2.68371346
56	retinal rod cell development (GO:0046548)	2.68158040
57	cytochrome complex assembly (GO:0017004)	2.66678090
58	sulfation (GO:0051923)	2.66585555
59	photoreceptor cell maintenance (GO:0045494)	2.65438920
60	resolution of meiotic recombination intermediates (GO:0000712)	2.65358831
61	attachment of spindle microtubules to kinetochore (GO:0008608)	2.65205941
62	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.63224818
63	mitochondrial respiratory chain complex assembly (GO:0033108)	2.62998108
64	pattern specification involved in kidney development (GO:0061004)	2.62789184
65	dorsal/ventral axis specification (GO:0009950)	2.61990456
66	protein complex biogenesis (GO:0070271)	2.59818290
67	regulation of collateral sprouting (GO:0048670)	2.59497972
68	organelle disassembly (GO:1903008)	2.58261182
69	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.57938296
70	auditory receptor cell differentiation (GO:0042491)	2.57739104
71	cilium morphogenesis (GO:0060271)	2.56207402
72	presynaptic membrane organization (GO:0097090)	2.55534143
73	indole-containing compound catabolic process (GO:0042436)	2.54771451
74	indolalkylamine catabolic process (GO:0046218)	2.54771451
75	tryptophan catabolic process (GO:0006569)	2.54771451
76	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.54584931
77	kynurenine metabolic process (GO:0070189)	2.53754799
78	artery development (GO:0060840)	2.52888067
79	intracellular protein transmembrane import (GO:0044743)	2.50603148
80	neuron fate determination (GO:0048664)	2.49338082
81	multicellular organism reproduction (GO:0032504)	2.48986706
82	spinal cord motor neuron differentiation (GO:0021522)	2.48638004
83	ncRNA catabolic process (GO:0034661)	2.48519745
84	somite development (GO:0061053)	2.48155778
85	reciprocal meiotic recombination (GO:0007131)	2.47993956
86	reciprocal DNA recombination (GO:0035825)	2.47993956
87	cilium or flagellum-dependent cell motility (GO:0001539)	2.47837936
88	ribonucleoprotein complex disassembly (GO:0032988)	2.47059458
89	retina layer formation (GO:0010842)	2.46049803
90	indolalkylamine metabolic process (GO:0006586)	2.45787906
91	spindle assembly involved in mitosis (GO:0090307)	2.44935635
92	kinetochore assembly (GO:0051382)	2.42968859
93	tryptophan metabolic process (GO:0006568)	2.42602161
94	axoneme assembly (GO:0035082)	2.42306245
95	NLS-bearing protein import into nucleus (GO:0006607)	2.42198911
96	embryonic pattern specification (GO:0009880)	2.41531482
97	regulation of DNA endoreduplication (GO:0032875)	2.41481442
98	photoreceptor cell development (GO:0042461)	2.40799073
99	embryonic axis specification (GO:0000578)	2.40705898
100	neuronal action potential (GO:0019228)	2.38785745

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.38433426
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.15818645
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.90758080
4	VDR_22108803_ChIP-Seq_LS180_Human	2.89876322
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.70291899
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.60753594
7	FUS_26573619_Chip-Seq_HEK293_Human	2.56995021
8	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.42623651
9	EWS_26573619_Chip-Seq_HEK293_Human	2.38803224
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.25397343
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.24967289
12	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.17054721
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.14698962
14	P300_19829295_ChIP-Seq_ESCs_Human	2.13977096
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.09517198
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.02572549
17	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.98457566
18	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.97526202
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.93665537
20	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.91152803
21	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.90081925
22	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.89758134
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.86226360
24	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.78917068
25	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.70287420
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.68769912
27	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.67898861
28	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.65806154
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.62723113
30	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.62005512
31	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.60814510
32	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.56964775
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.56964775
34	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.55755548
35	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.54349364
36	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.50601377
37	SMAD4_21799915_ChIP-Seq_A2780_Human	1.47136263
38	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.45485415
39	IGF1R_20145208_ChIP-Seq_DFB_Human	1.45388667
40	BCAT_22108803_ChIP-Seq_LS180_Human	1.45293644
41	STAT3_23295773_ChIP-Seq_U87_Human	1.45253134
42	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.45184215
43	ELK1_19687146_ChIP-ChIP_HELA_Human	1.44522293
44	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.43871753
45	AR_25329375_ChIP-Seq_VCAP_Human	1.42752153
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.42421718
47	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.42346562
48	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.42327693
49	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.40447209
50	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.39319294
51	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.39102487
52	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.35603029
53	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.34749428
54	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.34177675
55	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.34016731
56	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.33595011
57	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.33447780
58	TCF4_22108803_ChIP-Seq_LS180_Human	1.32487911
59	RNF2_27304074_Chip-Seq_NSC_Mouse	1.31664233
60	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.31617672
61	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.31587142
62	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.31262956
63	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.31180937
64	VDR_23849224_ChIP-Seq_CD4+_Human	1.29530137
65	MYC_18940864_ChIP-ChIP_HL60_Human	1.28656072
66	P53_22387025_ChIP-Seq_ESCs_Mouse	1.27052082
67	TCF4_23295773_ChIP-Seq_U87_Human	1.25959284
68	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.24207160
69	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.23024137
70	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.21665370
71	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.21542904
72	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21284796
73	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.20400837
74	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.20400837
75	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.19643340
76	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.19289585
77	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16284266
78	IRF1_19129219_ChIP-ChIP_H3396_Human	1.16047691
79	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.15375842
80	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.14031193
81	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12515013
82	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.12506724
83	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.12224161
84	P300_18555785_Chip-Seq_ESCs_Mouse	1.11774816
85	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.10791511
86	EZH2_22144423_ChIP-Seq_EOC_Human	1.08396704
87	AHR_22903824_ChIP-Seq_MCF-7_Human	1.07470653
88	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.06190477
89	NANOG_19829295_ChIP-Seq_ESCs_Human	1.03911675
90	SOX2_19829295_ChIP-Seq_ESCs_Human	1.03911675
91	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.03823777
92	TP53_22573176_ChIP-Seq_HFKS_Human	1.03418641
93	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.02731881
94	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.02471344
95	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.01546409
96	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.01420287
97	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.01061418
98	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.99460216
99	CDX2_22108803_ChIP-Seq_LS180_Human	0.99280958
100	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.98632950

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	3.59147115
2	MP0003880_abnormal_central_pattern	3.48224786
3	MP0003136_yellow_coat_color	2.61774626
4	MP0003195_calcinosis	2.57673751
5	MP0006292_abnormal_olfactory_placode	2.55552720
6	MP0000372_irregular_coat_pigmentation	2.53233898
7	MP0003890_abnormal_embryonic-extraembry	2.51512719
8	MP0001188_hyperpigmentation	2.41913593
9	MP0001986_abnormal_taste_sensitivity	2.30526372
10	MP0008877_abnormal_DNA_methylation	2.28808157
11	MP0005551_abnormal_eye_electrophysiolog	2.25150048
12	MP0008995_early_reproductive_senescence	2.24547967
13	MP0001968_abnormal_touch/_nociception	2.07480027
14	MP0008057_abnormal_DNA_replication	2.03520709
15	MP0000569_abnormal_digit_pigmentation	1.97986036
16	MP0003121_genomic_imprinting	1.94977159
17	MP0002736_abnormal_nociception_after	1.93984954
18	MP0002102_abnormal_ear_morphology	1.91623276
19	MP0005646_abnormal_pituitary_gland	1.90480237
20	MP0000631_abnormal_neuroendocrine_gland	1.87946313
21	MP0005645_abnormal_hypothalamus_physiol	1.86171516
22	MP0005084_abnormal_gallbladder_morpholo	1.84863249
23	MP0006072_abnormal_retinal_apoptosis	1.82498741
24	MP0002928_abnormal_bile_duct	1.79536728
25	MP0005075_abnormal_melanosome_morpholog	1.79151267
26	MP0005174_abnormal_tail_pigmentation	1.74131800
27	MP0001485_abnormal_pinna_reflex	1.72742083
28	MP0005187_abnormal_penis_morphology	1.64458576
29	MP0005253_abnormal_eye_physiology	1.64380965
30	MP0003718_maternal_effect	1.63180351
31	MP0001984_abnormal_olfaction	1.62362420
32	MP0008058_abnormal_DNA_repair	1.60082534
33	MP0002735_abnormal_chemical_nociception	1.56371007
34	MP0005423_abnormal_somatic_nervous	1.56164247
35	MP0004145_abnormal_muscle_electrophysio	1.54158716
36	MP0003567_abnormal_fetal_cardiomyocyte	1.50785958
37	MP0004133_heterotaxia	1.48344009
38	MP0002938_white_spotting	1.43353322
39	MP0008872_abnormal_physiological_respon	1.41200757
40	MP0003315_abnormal_perineum_morphology	1.36605739
41	MP0001324_abnormal_eye_pigmentation	1.34711729
42	MP0002638_abnormal_pupillary_reflex	1.33374577
43	MP0000778_abnormal_nervous_system	1.30454846
44	MP0005408_hypopigmentation	1.30085800
45	MP0004142_abnormal_muscle_tone	1.29734477
46	MP0003937_abnormal_limbs/digits/tail_de	1.28686770
47	MP0000516_abnormal_urinary_system	1.27372859
48	MP0005367_renal/urinary_system_phenotyp	1.27372859
49	MP0000427_abnormal_hair_cycle	1.25028135
50	MP0002009_preneoplasia	1.23871326
51	MP0000015_abnormal_ear_pigmentation	1.20134470
52	MP0000383_abnormal_hair_follicle	1.13340211
53	MP0002163_abnormal_gland_morphology	1.12816018
54	MP0004924_abnormal_behavior	1.12356047
55	MP0005386_behavior/neurological_phenoty	1.12356047
56	MP0002138_abnormal_hepatobiliary_system	1.10665404
57	MP0005195_abnormal_posterior_eye	1.09185098
58	MP0009046_muscle_twitch	1.08470276
59	MP0001293_anophthalmia	1.04792377
60	MP0003786_premature_aging	1.04639505
61	MP0002160_abnormal_reproductive_system	1.03742059
62	MP0001486_abnormal_startle_reflex	1.01712013
63	MP0000371_diluted_coat_color	1.01155796
64	MP0003646_muscle_fatigue	0.99974857
65	MP0002752_abnormal_somatic_nervous	0.99411355
66	MP0000955_abnormal_spinal_cord	0.98044555
67	MP0002734_abnormal_mechanical_nocicepti	0.97361906
68	MP0000647_abnormal_sebaceous_gland	0.97029716
69	MP0002090_abnormal_vision	0.96157148
70	MP0000613_abnormal_salivary_gland	0.95177226
71	MP0009745_abnormal_behavioral_response	0.91974523
72	MP0003011_delayed_dark_adaptation	0.91086020
73	MP0001286_abnormal_eye_development	0.90597059
74	MP0002272_abnormal_nervous_system	0.88278403
75	MP0005220_abnormal_exocrine_pancreas	0.85835075
76	MP0002557_abnormal_social/conspecific_i	0.84082941
77	MP0002067_abnormal_sensory_capabilities	0.83869884
78	MP0002751_abnormal_autonomic_nervous	0.83622277
79	MP0008961_abnormal_basal_metabolism	0.80646394
80	MP0002282_abnormal_trachea_morphology	0.79857442
81	MP0004147_increased_porphyrin_level	0.79375010
82	MP0006276_abnormal_autonomic_nervous	0.79309457
83	MP0005389_reproductive_system_phenotype	0.79262775
84	MP0010386_abnormal_urinary_bladder	0.77406351
85	MP0001529_abnormal_vocalization	0.77127788
86	MP0004215_abnormal_myocardial_fiber	0.76680942
87	MP0002234_abnormal_pharynx_morphology	0.76540793
88	MP0004742_abnormal_vestibular_system	0.76465891
89	MP0003183_abnormal_peptide_metabolism	0.75884321
90	MP0002095_abnormal_skin_pigmentation	0.75043442
91	MP0005670_abnormal_white_adipose	0.74391986
92	MP0003943_abnormal_hepatobiliary_system	0.73756833
93	MP0005391_vision/eye_phenotype	0.73725168
94	MP0003119_abnormal_digestive_system	0.73393431
95	MP0004957_abnormal_blastocyst_morpholog	0.72292422
96	MP0003936_abnormal_reproductive_system	0.71056869
97	MP0000538_abnormal_urinary_bladder	0.70923535
98	MP0003868_abnormal_feces_composition	0.69680131
99	MP0005310_abnormal_salivary_gland	0.69510546
100	MP0001145_abnormal_male_reproductive	0.69051866

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	3.84677423
2	Concave nail (HP:0001598)	3.81757590
3	Abnormality of midbrain morphology (HP:0002418)	3.46385695
4	Molar tooth sign on MRI (HP:0002419)	3.46385695
5	Pancreatic cysts (HP:0001737)	3.34551833
6	Cerebellar dysplasia (HP:0007033)	3.10709212
7	Abnormality of alanine metabolism (HP:0010916)	3.07117330
8	Hyperalaninemia (HP:0003348)	3.07117330
9	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.07117330
10	Septo-optic dysplasia (HP:0100842)	3.06844178
11	Type II lissencephaly (HP:0007260)	3.01307603
12	Pancreatic fibrosis (HP:0100732)	2.96287249
13	Nephronophthisis (HP:0000090)	2.95935572
14	Aqueductal stenosis (HP:0002410)	2.92310359
15	Intestinal atresia (HP:0011100)	2.87962116
16	Medial flaring of the eyebrow (HP:0010747)	2.86934775
17	True hermaphroditism (HP:0010459)	2.80997737
18	Broad-based gait (HP:0002136)	2.76514184
19	Chronic hepatic failure (HP:0100626)	2.73984137
20	Congenital stationary night blindness (HP:0007642)	2.69813687
21	Gait imbalance (HP:0002141)	2.61309447
22	Volvulus (HP:0002580)	2.55631393
23	Congenital primary aphakia (HP:0007707)	2.55291557
24	Oligodactyly (hands) (HP:0001180)	2.49653282
25	Genital tract atresia (HP:0001827)	2.47250745
26	Vaginal atresia (HP:0000148)	2.45337894
27	Chronic sinusitis (HP:0011109)	2.38302737
28	Aplastic anemia (HP:0001915)	2.34678856
29	Abnormality of the renal medulla (HP:0100957)	2.29688590
30	Bifid tongue (HP:0010297)	2.29018093
31	Lipid accumulation in hepatocytes (HP:0006561)	2.28658051
32	Tubulointerstitial nephritis (HP:0001970)	2.28635524
33	Increased hepatocellular lipid droplets (HP:0006565)	2.26772547
34	Protruding tongue (HP:0010808)	2.24721147
35	Lissencephaly (HP:0001339)	2.18152623
36	Nephrogenic diabetes insipidus (HP:0009806)	2.17510771
37	Poor coordination (HP:0002370)	2.17386832
38	Abnormality of the parathyroid morphology (HP:0011766)	2.14142259
39	Esophageal atresia (HP:0002032)	2.08631416
40	Absent septum pellucidum (HP:0001331)	2.04284686
41	Mitochondrial inheritance (HP:0001427)	2.03907421
42	Gaze-evoked nystagmus (HP:0000640)	2.02996384
43	Abolished electroretinogram (ERG) (HP:0000550)	2.02671926
44	Increased CSF lactate (HP:0002490)	2.02426910
45	Small hand (HP:0200055)	2.01553031
46	Inability to walk (HP:0002540)	1.98223205
47	Clumsiness (HP:0002312)	1.98108308
48	Abnormality of the nasal septum (HP:0000419)	1.96691894
49	Optic nerve hypoplasia (HP:0000609)	1.94635316
50	Growth hormone deficiency (HP:0000824)	1.93359772
51	Cystic liver disease (HP:0006706)	1.91470994
52	Drooling (HP:0002307)	1.90781135
53	Dandy-Walker malformation (HP:0001305)	1.90729744
54	Central scotoma (HP:0000603)	1.90651716
55	Abnormality of macular pigmentation (HP:0008002)	1.89745463
56	Hypoplasia of the pons (HP:0012110)	1.89003397
57	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.87920258
58	Abnormality of the pons (HP:0007361)	1.87210646
59	Gastrointestinal atresia (HP:0002589)	1.86928130
60	Dyschromatopsia (HP:0007641)	1.85868266
61	Short hallux (HP:0010109)	1.85356231
62	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.84138147
63	Narrow forehead (HP:0000341)	1.82619716
64	Carpal bone hypoplasia (HP:0001498)	1.82180862
65	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.81811459
66	Spontaneous abortion (HP:0005268)	1.81591058
67	Hypothermia (HP:0002045)	1.81044763
68	Anophthalmia (HP:0000528)	1.80397707
69	Abnormality of the septum pellucidum (HP:0007375)	1.80234280
70	Stenosis of the external auditory canal (HP:0000402)	1.80103740
71	Cupped ear (HP:0000378)	1.79406942
72	Acute encephalopathy (HP:0006846)	1.77795145
73	Aplasia of the musculature (HP:0100854)	1.77572001
74	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.76725147
75	Acute necrotizing encephalopathy (HP:0006965)	1.75781831
76	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.72596094
77	3-Methylglutaconic aciduria (HP:0003535)	1.72457712
78	Long nose (HP:0003189)	1.71219874
79	Abnormal pancreas size (HP:0012094)	1.71136566
80	Abnormality of the renal cortex (HP:0011035)	1.70884841
81	Median cleft lip (HP:0000161)	1.70762727
82	Anencephaly (HP:0002323)	1.69832665
83	Male pseudohermaphroditism (HP:0000037)	1.68391173
84	Neoplasm of the tracheobronchial system (HP:0100552)	1.67926464
85	Preaxial hand polydactyly (HP:0001177)	1.66375770
86	Sclerocornea (HP:0000647)	1.66050970
87	Excessive salivation (HP:0003781)	1.65527567
88	Astigmatism (HP:0000483)	1.64619296
89	Triphalangeal thumb (HP:0001199)	1.63908059
90	Abnormality of chromosome stability (HP:0003220)	1.63179781
91	Tubular atrophy (HP:0000092)	1.62917802
92	Progressive macrocephaly (HP:0004481)	1.62885827
93	Specific learning disability (HP:0001328)	1.62842274
94	Abnormality of the duodenum (HP:0002246)	1.62264605
95	Abnormal respiratory epithelium morphology (HP:0012253)	1.61938966
96	Abnormal respiratory motile cilium morphology (HP:0005938)	1.61938966
97	Gonadotropin excess (HP:0000837)	1.61267234
98	Renal cortical cysts (HP:0000803)	1.60583678
99	Ectopic kidney (HP:0000086)	1.59650502
100	Respiratory difficulties (HP:0002880)	1.58309185

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.05520774
2	STK16	3.99717906
3	AKT3	3.14281127
4	EIF2AK3	3.01885174
5	GRK1	2.63145994
6	WEE1	2.57396915
7	CASK	2.51189807
8	PBK	2.41801274
9	TRIM28	2.39091156
10	NUAK1	2.37274911
11	BRSK2	2.18188225
12	BMPR1B	2.13095013
13	ACVR1B	2.09619775
14	MST4	2.02597676
15	PDK2	1.98658255
16	BUB1	1.96492139
17	PNCK	1.91008255
18	STK39	1.87516056
19	TLK1	1.60169366
20	ADRBK2	1.54072207
21	MAP3K4	1.52260381
22	WNK4	1.52050678
23	OXSR1	1.50420803
24	INSRR	1.50303892
25	TSSK6	1.49739369
26	PAK3	1.41156932
27	WNK3	1.39824612
28	NEK2	1.37622282
29	FGFR2	1.33647488
30	TEC	1.28261780
31	TNIK	1.27317926
32	MARK1	1.25679941
33	MKNK2	1.17263793
34	MAPK15	1.09743152
35	PLK3	1.07312784
36	MAPK13	1.04756689
37	ZAK	1.03529071
38	MAP4K2	1.00289903
39	MAP2K7	0.97265685
40	ERBB3	0.96334350
41	CCNB1	0.91686583
42	TGFBR1	0.90701666
43	DYRK2	0.90490545
44	PLK4	0.88649646
45	CDC7	0.88158960
46	CDK3	0.87230937
47	PINK1	0.78173867
48	TIE1	0.77630945
49	PRKCG	0.76371780
50	SIK3	0.75870056
51	DYRK3	0.75412592
52	VRK1	0.74225004
53	SIK2	0.71973150
54	PLK1	0.71749824
55	STK3	0.70089090
56	PASK	0.69341402
57	SGK2	0.67917476
58	EIF2AK2	0.62944462
59	TAF1	0.61754037
60	CAMK1G	0.61560758
61	CDK19	0.61347022
62	SRPK1	0.59613072
63	PRKCE	0.58864637
64	STK4	0.58048075
65	FGFR1	0.54017089
66	MKNK1	0.53650057
67	NEK1	0.52723748
68	CAMK1D	0.52164005
69	ADRBK1	0.51768655
70	BCR	0.51468081
71	ERBB2	0.50307924
72	PIK3CG	0.49428928
73	TGFBR2	0.49010176
74	BCKDK	0.47978043
75	NTRK3	0.46742914
76	BRSK1	0.43690220
77	SGK223	0.42577184
78	SGK494	0.42577184
79	BRD4	0.40792185
80	OBSCN	0.40360470
81	ATM	0.40318534
82	PLK2	0.38282317
83	CSNK1E	0.30389143
84	PTK2B	0.29626661
85	PRKACA	0.28956201
86	FER	0.28541760
87	DAPK2	0.28185182
88	MARK3	0.27613552
89	CSNK2A1	0.27072154
90	PRKCQ	0.27037887
91	ITK	0.26029627
92	PKN1	0.25804367
93	RPS6KA5	0.25601335
94	PRKCB	0.24899090
95	NTRK2	0.24856262
96	CAMK1	0.24711025
97	YES1	0.24568375
98	PRKG1	0.23440337
99	PRKCI	0.22834562
100	CAMK2D	0.22258790

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.53050427
2	Homologous recombination_Homo sapiens_hsa03440	3.37769291
3	Fanconi anemia pathway_Homo sapiens_hsa03460	2.69238971
4	RNA polymerase_Homo sapiens_hsa03020	2.55274398
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.33620472
6	Basal transcription factors_Homo sapiens_hsa03022	2.33081458
7	Phototransduction_Homo sapiens_hsa04744	2.16141664
8	Propanoate metabolism_Homo sapiens_hsa00640	2.15251913
9	RNA degradation_Homo sapiens_hsa03018	2.11918979
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.00872054
11	Parkinsons disease_Homo sapiens_hsa05012	1.98397599
12	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.93108400
13	Proteasome_Homo sapiens_hsa03050	1.90415196
14	Nicotine addiction_Homo sapiens_hsa05033	1.88221356
15	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.78429032
16	Steroid biosynthesis_Homo sapiens_hsa00100	1.77769857
17	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.68018271
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.65876562
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.62407169
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.61239040
21	Huntingtons disease_Homo sapiens_hsa05016	1.60462516
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.58069637
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.53410570
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.51818846
25	Regulation of autophagy_Homo sapiens_hsa04140	1.51199812
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.43543162
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.41143602
28	Butanoate metabolism_Homo sapiens_hsa00650	1.40944642
29	One carbon pool by folate_Homo sapiens_hsa00670	1.40358094
30	Caffeine metabolism_Homo sapiens_hsa00232	1.36557259
31	Selenocompound metabolism_Homo sapiens_hsa00450	1.34262721
32	Cardiac muscle contraction_Homo sapiens_hsa04260	1.25915490
33	Non-homologous end-joining_Homo sapiens_hsa03450	1.24301906
34	Ribosome_Homo sapiens_hsa03010	1.22565153
35	Taste transduction_Homo sapiens_hsa04742	1.22237853
36	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.19881112
37	RNA transport_Homo sapiens_hsa03013	1.18695025
38	Ether lipid metabolism_Homo sapiens_hsa00565	1.14580492
39	Peroxisome_Homo sapiens_hsa04146	1.13358666
40	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.12611112
41	Alzheimers disease_Homo sapiens_hsa05010	1.09288413
42	Tryptophan metabolism_Homo sapiens_hsa00380	1.08931711
43	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.08822374
44	Circadian rhythm_Homo sapiens_hsa04710	1.06305658
45	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.02229701
46	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.01886060
47	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.01030524
48	Mismatch repair_Homo sapiens_hsa03430	0.99385479
49	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.96044579
50	Olfactory transduction_Homo sapiens_hsa04740	0.95590195
51	Asthma_Homo sapiens_hsa05310	0.90712500
52	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.90104945
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.86387615
54	Purine metabolism_Homo sapiens_hsa00230	0.83117979
55	Nucleotide excision repair_Homo sapiens_hsa03420	0.82855415
56	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.81051265
57	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.80429052
58	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.77410538
59	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.74470672
60	Cell cycle_Homo sapiens_hsa04110	0.73652835
61	Mineral absorption_Homo sapiens_hsa04978	0.70395395
62	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.68081972
63	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.67609145
64	Fatty acid metabolism_Homo sapiens_hsa01212	0.67086356
65	Fatty acid degradation_Homo sapiens_hsa00071	0.66803500
66	Pyrimidine metabolism_Homo sapiens_hsa00240	0.65843295
67	Pyruvate metabolism_Homo sapiens_hsa00620	0.64854644
68	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.64378882
69	Retinol metabolism_Homo sapiens_hsa00830	0.64321128
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.63619113
71	Circadian entrainment_Homo sapiens_hsa04713	0.63047626
72	Amphetamine addiction_Homo sapiens_hsa05031	0.60274013
73	Chemical carcinogenesis_Homo sapiens_hsa05204	0.60181691
74	Sulfur metabolism_Homo sapiens_hsa00920	0.55464659
75	ABC transporters_Homo sapiens_hsa02010	0.55070740
76	Fat digestion and absorption_Homo sapiens_hsa04975	0.50506318
77	Glycerolipid metabolism_Homo sapiens_hsa00561	0.49571409
78	Calcium signaling pathway_Homo sapiens_hsa04020	0.47390806
79	Metabolic pathways_Homo sapiens_hsa01100	0.47244811
80	Serotonergic synapse_Homo sapiens_hsa04726	0.47099306
81	beta-Alanine metabolism_Homo sapiens_hsa00410	0.46360093
82	p53 signaling pathway_Homo sapiens_hsa04115	0.43882117
83	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.43711486
84	Cocaine addiction_Homo sapiens_hsa05030	0.42671495
85	cAMP signaling pathway_Homo sapiens_hsa04024	0.42190853
86	Wnt signaling pathway_Homo sapiens_hsa04310	0.41642517
87	Alcoholism_Homo sapiens_hsa05034	0.39858449
88	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.39713508
89	Insulin secretion_Homo sapiens_hsa04911	0.39247378
90	Basal cell carcinoma_Homo sapiens_hsa05217	0.39099361
91	Tight junction_Homo sapiens_hsa04530	0.38782103
92	Glutathione metabolism_Homo sapiens_hsa00480	0.37659619
93	Axon guidance_Homo sapiens_hsa04360	0.36606754
94	Glutamatergic synapse_Homo sapiens_hsa04724	0.36240425
95	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.35687752
96	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.35279943
97	Spliceosome_Homo sapiens_hsa03040	0.34647420
98	Dopaminergic synapse_Homo sapiens_hsa04728	0.34018045
99	Collecting duct acid secretion_Homo sapiens_hsa04966	0.31034447
100	Hippo signaling pathway_Homo sapiens_hsa04390	0.31013313

SRP72P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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