SRP9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.01729174
2ribosomal small subunit assembly (GO:0000028)4.89171896
3proteasome assembly (GO:0043248)4.74561067
4DNA double-strand break processing (GO:0000729)4.54653128
5* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.44657295
6* cotranslational protein targeting to membrane (GO:0006613)4.32568739
7* protein targeting to ER (GO:0045047)4.32001416
8signal peptide processing (GO:0006465)4.31995727
9Golgi transport vesicle coating (GO:0048200)4.16339577
10COPI coating of Golgi vesicle (GO:0048205)4.16339577
11* protein localization to endoplasmic reticulum (GO:0070972)4.14994867
12viral transcription (GO:0019083)4.14092136
13formation of translation preinitiation complex (GO:0001731)4.12233980
14translational termination (GO:0006415)4.11317987
15* establishment of protein localization to endoplasmic reticulum (GO:0072599)4.09301666
16ribosomal large subunit biogenesis (GO:0042273)3.94653117
17purine nucleobase biosynthetic process (GO:0009113)3.89911933
18maturation of SSU-rRNA (GO:0030490)3.77513545
19GDP-mannose metabolic process (GO:0019673)3.75810059
20translational elongation (GO:0006414)3.75260408
21negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.73703501
22translational initiation (GO:0006413)3.70150276
23establishment of integrated proviral latency (GO:0075713)3.68665284
24* translation (GO:0006412)3.68410780
25nucleobase biosynthetic process (GO:0046112)3.65546024
26ribosomal small subunit biogenesis (GO:0042274)3.65252151
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.59575287
28positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.58262854
29termination of RNA polymerase III transcription (GO:0006386)3.55566135
30transcription elongation from RNA polymerase III promoter (GO:0006385)3.55566135
31protein neddylation (GO:0045116)3.53426419
32ribonucleoprotein complex biogenesis (GO:0022613)3.52475869
33regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.51703269
34DNA damage response, detection of DNA damage (GO:0042769)3.50410268
35histone exchange (GO:0043486)3.50354908
36maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.50243722
37regulation of cellular amino acid metabolic process (GO:0006521)3.46255157
38antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.44418802
39DNA ligation (GO:0006266)3.44342729
40ribosome biogenesis (GO:0042254)3.42657742
41ribosome assembly (GO:0042255)3.41961699
42L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.40929090
43deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.40399810
44folic acid metabolic process (GO:0046655)3.40221200
45anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.39677111
46protein retention in ER lumen (GO:0006621)3.36076721
47deoxyribose phosphate biosynthetic process (GO:0046385)3.33084417
482-deoxyribonucleotide biosynthetic process (GO:0009265)3.33084417
49negative regulation of ligase activity (GO:0051352)3.31865975
50negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.31865975
51DNA replication-independent nucleosome organization (GO:0034724)3.30797266
52DNA replication-independent nucleosome assembly (GO:0006336)3.30797266
53negative regulation of DNA recombination (GO:0045910)3.30710748
54regulation of mitochondrial translation (GO:0070129)3.30200967
55nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.26937966
56nucleobase-containing small molecule interconversion (GO:0015949)3.26853026
57DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.24685981
58rRNA modification (GO:0000154)3.24570988
59viral life cycle (GO:0019058)3.23830695
60regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.22648801
61regulation of mitotic spindle checkpoint (GO:1903504)3.22648801
62positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.22584801
63protein maturation by protein folding (GO:0022417)3.22463311
64signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.19795648
65intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.19795648
66signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.19634402
67signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.19634402
68signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.19634402
69L-methionine salvage (GO:0071267)3.19474507
70L-methionine biosynthetic process (GO:0071265)3.19474507
71amino acid salvage (GO:0043102)3.19474507
72cellular protein complex disassembly (GO:0043624)3.18924047
73guanosine-containing compound biosynthetic process (GO:1901070)3.17378277
74DNA replication checkpoint (GO:0000076)3.14607483
75somatic hypermutation of immunoglobulin genes (GO:0016446)3.14236839
76somatic diversification of immune receptors via somatic mutation (GO:0002566)3.14236839
77histone H2A acetylation (GO:0043968)3.14119748
78regulation of helicase activity (GO:0051095)3.13824305
79mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.12089697
80signal transduction involved in DNA damage checkpoint (GO:0072422)3.09099658
81signal transduction involved in DNA integrity checkpoint (GO:0072401)3.09099658
82positive regulation of ligase activity (GO:0051351)3.08737367
83cellular component biogenesis (GO:0044085)3.03614526
84signal transduction involved in cell cycle checkpoint (GO:0072395)3.02621344
85rRNA processing (GO:0006364)3.00507669
867-methylguanosine mRNA capping (GO:0006370)3.00496699
87antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.97674224
88L-serine metabolic process (GO:0006563)2.97044904
89DNA catabolic process, exonucleolytic (GO:0000738)2.96585917
90protein deneddylation (GO:0000338)2.95949017
91pseudouridine synthesis (GO:0001522)2.95231854
92deoxyribonucleotide biosynthetic process (GO:0009263)2.93965998
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.93486998
94nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93320451
95intraciliary transport (GO:0042073)2.91327932
96DNA replication-dependent nucleosome assembly (GO:0006335)2.90708325
97DNA replication-dependent nucleosome organization (GO:0034723)2.90708325
98rRNA metabolic process (GO:0016072)2.90518134
99non-recombinational repair (GO:0000726)2.90298255
100double-strand break repair via nonhomologous end joining (GO:0006303)2.90298255
1017-methylguanosine RNA capping (GO:0009452)2.89579971
102RNA capping (GO:0036260)2.89579971
103telomere maintenance via semi-conservative replication (GO:0032201)2.87141568
104protein localization to kinetochore (GO:0034501)2.86882837
105replication fork processing (GO:0031297)2.86043151
106cullin deneddylation (GO:0010388)2.85912079
107respiratory chain complex IV assembly (GO:0008535)2.85783891
108negative regulation of DNA-dependent DNA replication (GO:2000104)2.84767807
109pteridine-containing compound biosynthetic process (GO:0042559)2.84065293
110* protein targeting to membrane (GO:0006612)2.83796931
111DNA strand elongation involved in DNA replication (GO:0006271)2.83162897
112spindle checkpoint (GO:0031577)2.82428688
113establishment of protein localization to mitochondrial membrane (GO:0090151)2.82283144
114mitotic spindle checkpoint (GO:0071174)2.82147966
115water-soluble vitamin biosynthetic process (GO:0042364)2.82122150
116establishment of viral latency (GO:0019043)2.81901074
117organelle disassembly (GO:1903008)2.81823724
118folic acid-containing compound biosynthetic process (GO:0009396)2.81674896
119IMP biosynthetic process (GO:0006188)2.79914591
120negative regulation of mitotic sister chromatid separation (GO:2000816)2.77901157
121negative regulation of sister chromatid segregation (GO:0033046)2.77901157
122negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.77901157
123negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.77901157
124negative regulation of mitotic sister chromatid segregation (GO:0033048)2.77901157
125histone mRNA metabolic process (GO:0008334)2.77852785
126resolution of meiotic recombination intermediates (GO:0000712)2.76716402
127CENP-A containing nucleosome assembly (GO:0034080)2.75187208
128regulation of ubiquitin-protein transferase activity (GO:0051438)2.73935961
129protein targeting to mitochondrion (GO:0006626)2.72724606
130peptidyl-histidine modification (GO:0018202)2.72679115
131negative regulation of chromosome segregation (GO:0051985)2.70263374
132establishment of protein localization to mitochondrion (GO:0072655)2.70207766
133spliceosomal snRNP assembly (GO:0000387)2.69823528
134termination of RNA polymerase I transcription (GO:0006363)2.69640987
135cholesterol biosynthetic process (GO:0006695)2.68701588
136DNA strand elongation (GO:0022616)2.68603843
137chromatin remodeling at centromere (GO:0031055)2.68436095
138protein complex disassembly (GO:0043241)2.67801325
139kinetochore organization (GO:0051383)2.66891106
140mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.66482611
141postreplication repair (GO:0006301)2.66212959
142telomere maintenance via recombination (GO:0000722)2.66107537
143mitotic metaphase plate congression (GO:0007080)2.65380219
144transcription from RNA polymerase I promoter (GO:0006360)2.64694474
145regulation of ligase activity (GO:0051340)2.64473462
146chaperone-mediated protein transport (GO:0072321)2.64464323
147pyrimidine nucleobase catabolic process (GO:0006208)2.64019854
148cell cycle G1/S phase transition (GO:0044843)2.63709966
149G1/S transition of mitotic cell cycle (GO:0000082)2.63709966
150macromolecular complex disassembly (GO:0032984)2.63137954
151metaphase plate congression (GO:0051310)2.62268098
152sequestering of actin monomers (GO:0042989)2.61016976
153kinetochore assembly (GO:0051382)2.59322435
154mitotic spindle assembly checkpoint (GO:0007094)2.59096899
155protein K11-linked ubiquitination (GO:0070979)2.59050848
156ATP synthesis coupled proton transport (GO:0015986)2.56576452
157energy coupled proton transport, down electrochemical gradient (GO:0015985)2.56576452
158presynaptic membrane assembly (GO:0097105)2.56399121
159spindle assembly checkpoint (GO:0071173)2.55709390
160mitochondrial respiratory chain complex assembly (GO:0033108)2.54658552
161regulation of centriole replication (GO:0046599)2.53758739
162microtubule depolymerization (GO:0007019)2.52379187
163regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.51743391
164regulation of mitotic metaphase/anaphase transition (GO:0030071)2.51743391
165sterol biosynthetic process (GO:0016126)2.51577339
166ribonucleoprotein complex disassembly (GO:0032988)2.51417572
167nucleotide-excision repair, DNA gap filling (GO:0006297)2.50196797
168regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.50038420
169branched-chain amino acid catabolic process (GO:0009083)2.49189555
170protein complex biogenesis (GO:0070271)2.47801807
171regulation of mitotic sister chromatid segregation (GO:0033047)2.46992238
172regulation of sister chromatid segregation (GO:0033045)2.46992238
173regulation of mitotic sister chromatid separation (GO:0010965)2.46992238
174tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.46916089
175RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.46916089
176nonmotile primary cilium assembly (GO:0035058)2.46590904

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.95641361
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.94151399
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.82116693
4E2F7_22180533_ChIP-Seq_HELA_Human3.79651509
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.65489230
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.59490805
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.30627112
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.28607558
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.02309390
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.88989153
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.81516485
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.68912573
13* VDR_23849224_ChIP-Seq_CD4+_Human2.65784929
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.64062433
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.59838848
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55905112
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.48784408
18IGF1R_20145208_ChIP-Seq_DFB_Human2.43034082
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.41447144
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.40827790
21DCP1A_22483619_ChIP-Seq_HELA_Human2.38521484
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.28711543
23EWS_26573619_Chip-Seq_HEK293_Human2.27309526
24FUS_26573619_Chip-Seq_HEK293_Human2.26271654
25GABP_19822575_ChIP-Seq_HepG2_Human2.26026234
26XRN2_22483619_ChIP-Seq_HELA_Human2.23335260
27* ZNF274_21170338_ChIP-Seq_K562_Hela2.20771705
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.19058041
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.16783096
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.15168265
31TAF15_26573619_Chip-Seq_HEK293_Human2.15000176
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14139448
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12157017
34NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09386028
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04888296
36FOXP3_21729870_ChIP-Seq_TREG_Human2.01619988
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.00957890
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.97802002
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94778262
40ELK1_19687146_ChIP-ChIP_HELA_Human1.94424789
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93700158
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.92853525
43VDR_22108803_ChIP-Seq_LS180_Human1.91134577
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.90705998
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.87848424
46* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.87527907
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87068921
48* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.83245886
49KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.82331198
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.82247409
51* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.80939374
52TTF2_22483619_ChIP-Seq_HELA_Human1.72680788
53* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.70761235
54P300_19829295_ChIP-Seq_ESCs_Human1.70373863
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69147420
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69083482
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67978915
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.67822210
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67666923
60CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.67662002
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.66918811
62TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.66545840
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.64829598
64GBX2_23144817_ChIP-Seq_PC3_Human1.64056943
65* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.61155580
66* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.61068368
67* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53461602
68KDM5A_27292631_Chip-Seq_BREAST_Human1.49043879
69CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.43559967
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43207112
71* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41655301
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39676879
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36072631
74ELK1_22589737_ChIP-Seq_MCF10A_Human1.35810990
75NANOG_16153702_ChIP-ChIP_HESCs_Human1.35746133
76SOX2_16153702_ChIP-ChIP_HESCs_Human1.35390149
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34526872
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31581548
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30778352
80TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30387725
81IRF1_19129219_ChIP-ChIP_H3396_Human1.30342723
82IRF8_22096565_ChIP-ChIP_GC-B_Human1.28094612
83FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27847258
84IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.27187143
85* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27016222
86TFEB_21752829_ChIP-Seq_HELA_Human1.26354353
87AR_21909140_ChIP-Seq_LNCAP_Human1.26277097
88ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.25784729
89SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25404884
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25316226
91NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24367034
92SPI1_23547873_ChIP-Seq_NB4_Human1.23734772
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23225372
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.22205526
95FOXM1_23109430_ChIP-Seq_U2OS_Human1.21461472
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19823487
97PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19806819
98E2F1_21310950_ChIP-Seq_MCF-7_Human1.18957450
99MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18763389
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17765620
101POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15089492
102SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14169993
103NOTCH1_21737748_ChIP-Seq_TLL_Human1.14014460
104FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12707037
105MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12417757
106GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11554229
107* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10744227
108* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10210286
109CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09695623
110PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08598132
111OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08455044
112STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06792557
113YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06252581
114HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05650232
115* EZH2_27294783_Chip-Seq_NPCs_Mouse1.05250042
116KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05112453
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04854400
118CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04260633
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04200441
120RNF2_27304074_Chip-Seq_NSC_Mouse1.03750428
121CIITA_25753668_ChIP-Seq_RAJI_Human1.03501889
122E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03307378
123* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00496527
124STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00344033
125ER_23166858_ChIP-Seq_MCF-7_Human1.00076210
126CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98065038
127IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98039301
128CBP_20019798_ChIP-Seq_JUKART_Human0.98039301
129TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97255886
130KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97150606
131* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95645199
132PIAS1_25552417_ChIP-Seq_VCAP_Human0.95391025
133* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95153243
134SMAD3_21741376_ChIP-Seq_EPCs_Human0.94377494
135DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94101527
136RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93724015
137SMAD4_21799915_ChIP-Seq_A2780_Human0.93643831
138MYC_18940864_ChIP-ChIP_HL60_Human0.93577048
139NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93410475
140FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91686248
141* NANOG_18555785_Chip-Seq_ESCs_Mouse0.91547314
142IRF8_21731497_ChIP-ChIP_J774_Mouse0.91275689
143TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91263111
144NANOG_19829295_ChIP-Seq_ESCs_Human0.91011010
145SOX2_19829295_ChIP-Seq_ESCs_Human0.91011010
146SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90290730
147MYB_21317192_ChIP-Seq_ERMYB_Mouse0.89732346
148EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89643230
149ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88170928
150MYC_22102868_ChIP-Seq_BL_Human0.85635044
151TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83687581
152EGR1_19374776_ChIP-ChIP_THP-1_Human0.83361910
153* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.82728679
154CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82208221
155TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81714173
156PPARA_22158963_ChIP-Seq_LIVER_Mouse0.81659858

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.93528375
2MP0004957_abnormal_blastocyst_morpholog3.39856131
3MP0001529_abnormal_vocalization2.82914567
4MP0005220_abnormal_exocrine_pancreas2.69336125
5MP0003186_abnormal_redox_activity2.65644195
6MP0003806_abnormal_nucleotide_metabolis2.53010554
7MP0002102_abnormal_ear_morphology2.52290387
8MP0002139_abnormal_hepatobiliary_system2.44363404
9MP0003880_abnormal_central_pattern2.40911057
10MP0001666_abnormal_nutrient_absorption2.36507571
11MP0005365_abnormal_bile_salt2.36037864
12MP0003111_abnormal_nucleus_morphology2.31692162
13MP0006072_abnormal_retinal_apoptosis2.27562349
14MP0003122_maternal_imprinting2.26647967
15MP0003077_abnormal_cell_cycle2.22071729
16MP0010094_abnormal_chromosome_stability2.20880217
17MP0008058_abnormal_DNA_repair2.12364381
18MP0005083_abnormal_biliary_tract2.11820738
19MP0003890_abnormal_embryonic-extraembry2.04115167
20MP0008789_abnormal_olfactory_epithelium2.03121922
21MP0001984_abnormal_olfaction2.01230997
22MP0009333_abnormal_splenocyte_physiolog2.00846811
23MP0003121_genomic_imprinting1.93044958
24MP0006292_abnormal_olfactory_placode1.92810619
25MP0005085_abnormal_gallbladder_physiolo1.91160847
26MP0002693_abnormal_pancreas_physiology1.86247278
27MP0001764_abnormal_homeostasis1.83970643
28MP0005499_abnormal_olfactory_system1.83582694
29MP0005394_taste/olfaction_phenotype1.83582694
30MP0001293_anophthalmia1.82957812
31MP0000490_abnormal_crypts_of1.81572405
32MP0005084_abnormal_gallbladder_morpholo1.79128103
33MP0001835_abnormal_antigen_presentation1.77527379
34MP0003718_maternal_effect1.76796060
35MP0004133_heterotaxia1.75922369
36MP0005671_abnormal_response_to1.75614963
37MP0009697_abnormal_copulation1.75115530
38MP0008007_abnormal_cellular_replicative1.73000410
39MP0001188_hyperpigmentation1.72708664
40MP0006036_abnormal_mitochondrial_physio1.70568114
41MP0002396_abnormal_hematopoietic_system1.69503371
42MP0002938_white_spotting1.68530560
43MP0003436_decreased_susceptibility_to1.67104713
44MP0008932_abnormal_embryonic_tissue1.67038600
45MP0003763_abnormal_thymus_physiology1.61137864
46MP0003787_abnormal_imprinting1.60927355
47MP0005253_abnormal_eye_physiology1.60884878
48MP0003937_abnormal_limbs/digits/tail_de1.57033694
49MP0003941_abnormal_skin_development1.55710190
50MP0002751_abnormal_autonomic_nervous1.54834279
51MP0003567_abnormal_fetal_cardiomyocyte1.51691083
52MP0003123_paternal_imprinting1.51602397
53MP0003868_abnormal_feces_composition1.51401605
54MP0003195_calcinosis1.50922374
55MP0006276_abnormal_autonomic_nervous1.50490615
56MP0009785_altered_susceptibility_to1.45835196
57MP0002234_abnormal_pharynx_morphology1.45537222
58MP0001944_abnormal_pancreas_morphology1.44369383
59MP0003786_premature_aging1.41434868
60MP0004147_increased_porphyrin_level1.41368060
61MP0005636_abnormal_mineral_homeostasis1.36859319
62MP0003724_increased_susceptibility_to1.36485016
63MP0000778_abnormal_nervous_system1.34355965
64MP0000647_abnormal_sebaceous_gland1.34177242
65MP0003136_yellow_coat_color1.34059948
66MP0009379_abnormal_foot_pigmentation1.32002246
67MP0009643_abnormal_urine_homeostasis1.31508230
68MP0002233_abnormal_nose_morphology1.31330947
69MP0002736_abnormal_nociception_after1.31266469
70MP0008995_early_reproductive_senescence1.29094482
71MP0002166_altered_tumor_susceptibility1.28716552
72MP0000631_abnormal_neuroendocrine_gland1.28382726
73MP0003119_abnormal_digestive_system1.26285283
74MP0005332_abnormal_amino_acid1.24727168
75MP0000358_abnormal_cell_content/1.23990933
76MP0002138_abnormal_hepatobiliary_system1.22215559
77MP0000685_abnormal_immune_system1.22154954
78MP0002638_abnormal_pupillary_reflex1.22082614
79MP0005360_urolithiasis1.21144476
80MP0000858_altered_metastatic_potential1.19838738
81MP0005187_abnormal_penis_morphology1.19265465
82MP0002090_abnormal_vision1.19143952
83MP0002148_abnormal_hypersensitivity_rea1.19030297
84MP0005000_abnormal_immune_tolerance1.17661932
85MP0002019_abnormal_tumor_incidence1.17231831
86MP0008057_abnormal_DNA_replication1.17091898
87MP0001845_abnormal_inflammatory_respons1.16907912
88MP0005248_abnormal_Harderian_gland1.16345545
89MP0008469_abnormal_protein_level1.15022869
90MP0005551_abnormal_eye_electrophysiolog1.14691809
91MP0000372_irregular_coat_pigmentation1.14585536
92MP0005025_abnormal_response_to1.13649122
93MP0003221_abnormal_cardiomyocyte_apopto1.13425673
94MP0001286_abnormal_eye_development1.13357359
95MP0001853_heart_inflammation1.12618088
96MP0000049_abnormal_middle_ear1.12375121
97MP0005319_abnormal_enzyme/_coenzyme1.10794415
98MP0002398_abnormal_bone_marrow1.10518636
99MP0006054_spinal_hemorrhage1.10078059
100MP0001730_embryonic_growth_arrest1.09308448
101MP0002822_catalepsy1.08613971
102MP0002723_abnormal_immune_serum1.08537855
103MP0002420_abnormal_adaptive_immunity1.07562796
104MP0008260_abnormal_autophagy1.07256497
105MP0005389_reproductive_system_phenotype1.06728436
106MP0001819_abnormal_immune_cell1.06234875
107MP0004270_analgesia1.04903941
108MP0005391_vision/eye_phenotype1.04679188
109MP0005058_abnormal_lysosome_morphology1.04466136
110MP0001919_abnormal_reproductive_system1.04083996
111MP0009840_abnormal_foam_cell1.03766658
112MP0004215_abnormal_myocardial_fiber1.03005012
113MP0000689_abnormal_spleen_morphology1.02924936
114MP0005645_abnormal_hypothalamus_physiol1.02881623
115MP0000350_abnormal_cell_proliferation1.02758533
116MP0003011_delayed_dark_adaptation1.01612070
117MP0002722_abnormal_immune_system1.01606714
118MP0001986_abnormal_taste_sensitivity1.01327571
119MP0002006_tumorigenesis1.00816440
120MP0010352_gastrointestinal_tract_polyps1.00260849
121MP0002452_abnormal_antigen_presenting0.99879052
122MP0001929_abnormal_gametogenesis0.99563805
123MP0000716_abnormal_immune_system0.98993725
124MP0001545_abnormal_hematopoietic_system0.98771102
125MP0005397_hematopoietic_system_phenotyp0.98771102
126MP0002132_abnormal_respiratory_system0.98626053
127MP0001177_atelectasis0.98322934
128MP0001486_abnormal_startle_reflex0.97874745
129MP0002429_abnormal_blood_cell0.96847994
130MP0001485_abnormal_pinna_reflex0.96828912
131MP0003866_abnormal_defecation0.96689714
132MP0002084_abnormal_developmental_patter0.96494911
133MP0001800_abnormal_humoral_immune0.96282984
134MP0000313_abnormal_cell_death0.95974544
135MP0009046_muscle_twitch0.95319819
136MP0001145_abnormal_male_reproductive0.95140362
137MP0002419_abnormal_innate_immunity0.95025194
138MP0002697_abnormal_eye_size0.94711033
139MP0002837_dystrophic_cardiac_calcinosis0.94643458
140MP0010155_abnormal_intestine_physiology0.94182031
141MP0008877_abnormal_DNA_methylation0.93681531
142MP0005379_endocrine/exocrine_gland_phen0.93507947
143MP0002210_abnormal_sex_determination0.93355258
144MP0005451_abnormal_body_composition0.93144937
145MP0004808_abnormal_hematopoietic_stem0.92522659
146MP0002405_respiratory_system_inflammati0.91724081
147MP0001756_abnormal_urination0.89829640
148MP0003137_abnormal_impulse_conducting0.88910443
149MP0006035_abnormal_mitochondrial_morpho0.88797323
150MP0000598_abnormal_liver_morphology0.88776392
151MP0003959_abnormal_lean_body0.88454190
152MP0001542_abnormal_bone_strength0.88121242
153MP0001661_extended_life_span0.87827662
154MP0000609_abnormal_liver_physiology0.87675895
155MP0005408_hypopigmentation0.87534363
156MP0001299_abnormal_eye_distance/0.87366145
157MP0005310_abnormal_salivary_gland0.87157679
158MP0002184_abnormal_innervation0.87126758
159MP0008875_abnormal_xenobiotic_pharmacok0.87098402
160MP0003755_abnormal_palate_morphology0.86320106
161MP0002734_abnormal_mechanical_nocicepti0.86284843
162MP0002085_abnormal_embryonic_tissue0.84986337
163MP0003861_abnormal_nervous_system0.84730895
164MP0000653_abnormal_sex_gland0.84374560
165MP0010030_abnormal_orbit_morphology0.83277508
166MP0001968_abnormal_touch/_nociception0.82484234
167MP0002160_abnormal_reproductive_system0.82020827
168MP0009703_decreased_birth_body0.81027080
169MP0002557_abnormal_social/conspecific_i0.80959123
170MP0002752_abnormal_somatic_nervous0.80733052
171MP0002272_abnormal_nervous_system0.80030244
172MP0001697_abnormal_embryo_size0.78399537
173MP0002111_abnormal_tail_morphology0.77358621
174MP0000516_abnormal_urinary_system0.76847879
175MP0005367_renal/urinary_system_phenotyp0.76847879
176MP0000566_synostosis0.76806679
177MP0009672_abnormal_birth_weight0.76435637

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.18113940
2Abnormal number of erythroid precursors (HP:0012131)3.99860923
3Abnormality of the labia minora (HP:0012880)3.77939830
4Decreased activity of mitochondrial respiratory chain (HP:0008972)3.61603605
5Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.61603605
6Degeneration of anterior horn cells (HP:0002398)3.50672128
7Abnormality of the anterior horn cell (HP:0006802)3.50672128
8Reduced antithrombin III activity (HP:0001976)3.35249171
9Aplastic anemia (HP:0001915)3.24191378
10Birth length less than 3rd percentile (HP:0003561)3.23352002
11Reticulocytopenia (HP:0001896)3.13414092
12Hepatic necrosis (HP:0002605)3.03211599
13Microretrognathia (HP:0000308)3.02249042
14Abnormality of aromatic amino acid family metabolism (HP:0004338)2.98749369
15Type I transferrin isoform profile (HP:0003642)2.98336759
16Poor head control (HP:0002421)2.91292671
17Macrocytic anemia (HP:0001972)2.91037172
18Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.88359766
19Abnormal protein N-linked glycosylation (HP:0012347)2.88359766
20Abnormal protein glycosylation (HP:0012346)2.88359766
21Abnormal glycosylation (HP:0012345)2.88359766
22True hermaphroditism (HP:0010459)2.85619862
23Medial flaring of the eyebrow (HP:0010747)2.80627547
24Oral leukoplakia (HP:0002745)2.76652779
25Hepatocellular necrosis (HP:0001404)2.76124045
26Thrombocytosis (HP:0001894)2.68945805
27Abnormality of the intrinsic pathway (HP:0010989)2.68679539
28Methylmalonic acidemia (HP:0002912)2.67787538
29Congenital primary aphakia (HP:0007707)2.65756114
30Acute necrotizing encephalopathy (HP:0006965)2.64249311
31Pancreatic fibrosis (HP:0100732)2.63640327
32Gait imbalance (HP:0002141)2.61953198
33Hyperglycinemia (HP:0002154)2.61243629
34Vacuolated lymphocytes (HP:0001922)2.60883223
35Abnormal mitochondria in muscle tissue (HP:0008316)2.60882957
36Pancreatic cysts (HP:0001737)2.58261065
37Meckel diverticulum (HP:0002245)2.58069377
38Multiple enchondromatosis (HP:0005701)2.57867460
39Mitochondrial inheritance (HP:0001427)2.56229535
40Rough bone trabeculation (HP:0100670)2.55808674
41Progressive muscle weakness (HP:0003323)2.54908726
42Abnormality of alanine metabolism (HP:0010916)2.53876191
43Hyperalaninemia (HP:0003348)2.53876191
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.53876191
45Carpal bone hypoplasia (HP:0001498)2.52349683
46Increased serum pyruvate (HP:0003542)2.51184718
47Cortical dysplasia (HP:0002539)2.49282264
48Increased serum lactate (HP:0002151)2.48449100
49Generalized aminoaciduria (HP:0002909)2.48101739
50Abnormality of the ileum (HP:0001549)2.46467443
51Acute encephalopathy (HP:0006846)2.46186506
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.46117181
53Nephrogenic diabetes insipidus (HP:0009806)2.45523324
54Pallor (HP:0000980)2.45298091
55Abnormality of glycolysis (HP:0004366)2.42402414
56Increased CSF lactate (HP:0002490)2.41500611
57Abnormality of chromosome stability (HP:0003220)2.41088271
58Breast hypoplasia (HP:0003187)2.40461381
59Hypoglycemic coma (HP:0001325)2.39752059
60Genital tract atresia (HP:0001827)2.38571955
613-Methylglutaconic aciduria (HP:0003535)2.36463474
62Abnormal spermatogenesis (HP:0008669)2.34544136
63Vaginal atresia (HP:0000148)2.34158314
64Abnormal lung lobation (HP:0002101)2.29475233
65Beaking of vertebral bodies (HP:0004568)2.29405000
66Intestinal atresia (HP:0011100)2.27978305
67Lactic acidosis (HP:0003128)2.26718588
68Gout (HP:0001997)2.26590748
69Cerebral hypomyelination (HP:0006808)2.25412010
70Aplasia/Hypoplasia of the sacrum (HP:0008517)2.24247580
71Abnormality of midbrain morphology (HP:0002418)2.23549869
72Molar tooth sign on MRI (HP:0002419)2.23549869
73Trismus (HP:0000211)2.22009401
74Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.21222918
75Ependymoma (HP:0002888)2.19184812
76Volvulus (HP:0002580)2.18909457
77Abnormality of methionine metabolism (HP:0010901)2.18742391
78Abnormality of serum amino acid levels (HP:0003112)2.18720325
79Secondary amenorrhea (HP:0000869)2.18345044
80Medulloblastoma (HP:0002885)2.18259999
81Nephronophthisis (HP:0000090)2.17350990
82IgM deficiency (HP:0002850)2.16465245
83Chromosomal breakage induced by crosslinking agents (HP:0003221)2.15724667
84Pancytopenia (HP:0001876)2.11917071
85Lethargy (HP:0001254)2.11378397
86Cerebral edema (HP:0002181)2.09675198
87Abnormality of T cell physiology (HP:0011840)2.06335004
88Megaloblastic anemia (HP:0001889)2.05279263
89Hyperglycinuria (HP:0003108)2.04610439
90Exertional dyspnea (HP:0002875)2.04071422
91Increased intramyocellular lipid droplets (HP:0012240)2.03340027
92Progressive macrocephaly (HP:0004481)2.01678749
93Abnormality of aspartate family amino acid metabolism (HP:0010899)2.01100773
94Nausea (HP:0002018)2.00836830
95Methylmalonic aciduria (HP:0012120)2.00564345
96Supernumerary spleens (HP:0009799)1.99574972
97Lipid accumulation in hepatocytes (HP:0006561)1.99303998
98Chromsome breakage (HP:0040012)1.99132582
99Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.97645523
100Abnormality of the preputium (HP:0100587)1.96438331
101Petechiae (HP:0000967)1.93966109
102Glioma (HP:0009733)1.93956047
103Increased hepatocellular lipid droplets (HP:0006565)1.93278909
104Rhabdomyosarcoma (HP:0002859)1.93116736
105Increased muscle lipid content (HP:0009058)1.92186213
106Death in infancy (HP:0001522)1.91738433
107Postnatal microcephaly (HP:0005484)1.90823315
10811 pairs of ribs (HP:0000878)1.90771276
109Abnormality of dicarboxylic acid metabolism (HP:0010995)1.90389243
110Dicarboxylic aciduria (HP:0003215)1.90389243
111Broad foot (HP:0001769)1.89787763
112CNS demyelination (HP:0007305)1.89446906
113Azoospermia (HP:0000027)1.89256567
114Neoplasm of the adrenal gland (HP:0100631)1.89170791
115Aplasia/Hypoplasia of the tongue (HP:0010295)1.88845328
116Sloping forehead (HP:0000340)1.88561201
117Postaxial hand polydactyly (HP:0001162)1.87948015
118Small intestinal stenosis (HP:0012848)1.87608882
119Duodenal stenosis (HP:0100867)1.87608882
120Abnormality of the duodenum (HP:0002246)1.86738331
121Hypothermia (HP:0002045)1.84933759
122Colon cancer (HP:0003003)1.84686725
123Sparse eyelashes (HP:0000653)1.84598333
124Postaxial foot polydactyly (HP:0001830)1.84101932
125Hypobetalipoproteinemia (HP:0003563)1.83856417
126Exercise-induced muscle cramps (HP:0003710)1.83643615
127IgG deficiency (HP:0004315)1.83443814
128Steatorrhea (HP:0002570)1.82955157
129Renal Fanconi syndrome (HP:0001994)1.82315379
130Preaxial hand polydactyly (HP:0001177)1.82011582
131Decreased testicular size (HP:0008734)1.81271930
132Bifid tongue (HP:0010297)1.81013760
133Abnormality of T cells (HP:0002843)1.79946552
134Sclerocornea (HP:0000647)1.79849230
135Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.79376467
136Abnormal hemoglobin (HP:0011902)1.79060003
137Abnormality of monocarboxylic acid metabolism (HP:0010996)1.78720116
138Abnormality of the astrocytes (HP:0100707)1.76895970
139Astrocytoma (HP:0009592)1.76895970
140Absent thumb (HP:0009777)1.75282395
141Glycosuria (HP:0003076)1.75237406
142Abnormality of urine glucose concentration (HP:0011016)1.75237406
143Fat malabsorption (HP:0002630)1.75219434
144Abnormality of pyrimidine metabolism (HP:0004353)1.74592065
145Abnormal trabecular bone morphology (HP:0100671)1.74353745
146Respiratory failure (HP:0002878)1.74337321
147Poor coordination (HP:0002370)1.73689083
148Specific learning disability (HP:0001328)1.73656800
149Aplasia/hypoplasia of the uterus (HP:0008684)1.73554525
150Triphalangeal thumb (HP:0001199)1.73275601
151Septo-optic dysplasia (HP:0100842)1.71849269
152Short tibia (HP:0005736)1.71603852
153Gonadotropin excess (HP:0000837)1.70666150
154Brushfield spots (HP:0001088)1.70596628
155Abnormal biliary tract physiology (HP:0012439)1.70478399
156Bile duct proliferation (HP:0001408)1.70478399
157Optic nerve hypoplasia (HP:0000609)1.69526955
158Exercise intolerance (HP:0003546)1.68919007
159Respiratory difficulties (HP:0002880)1.68906982
160Abnormality of glycine metabolism (HP:0010895)1.67773391
161Abnormality of serine family amino acid metabolism (HP:0010894)1.67773391
162Oligodactyly (hands) (HP:0001180)1.67734074
163Neutropenia (HP:0001875)1.67628934
164Anencephaly (HP:0002323)1.67549788
165Poor suck (HP:0002033)1.67489987
166Atrophy/Degeneration involving motor neurons (HP:0007373)1.67465717
167Abnormality of the renal medulla (HP:0100957)1.67315110
168Pancreatic islet-cell hyperplasia (HP:0004510)1.67258517
169Occipital encephalocele (HP:0002085)1.67125538
170Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.65147945
171Hypoplastic pelvis (HP:0008839)1.64511541
172Abnormality of vitamin B metabolism (HP:0004340)1.64174348

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.58446186
2BUB13.80398157
3TRIM283.69987325
4EIF2AK13.65794376
5EIF2AK33.32775659
6STK163.07511861
7BCKDK2.95961354
8BCR2.90145531
9WEE12.86806456
10WNK32.82741336
11TESK22.80243178
12ACVR1B2.53507708
13MKNK12.52717295
14MKNK22.46999744
15ERBB32.44534803
16PASK2.15368732
17MAP4K22.12309764
18TESK12.07488572
19MAP3K42.02136232
20ERN11.98887733
21SCYL21.98776598
22IRAK31.92997083
23DYRK31.85363615
24PIM21.80287358
25TNIK1.79865747
26PLK41.78562737
27CASK1.77493738
28RPS6KA41.77089034
29BMPR1B1.76623383
30BRSK21.74824427
31NME11.67506142
32VRK11.65882644
33NEK21.61325240
34ZAP701.57755198
35VRK21.55520741
36MAP2K71.53016315
37IRAK41.51765710
38CSNK1G31.50721968
39CSNK1G11.50558076
40CSNK1G21.45581427
41SRPK11.42364793
42KDR1.40962787
43FLT31.36812620
44PLK21.33787170
45CDC71.33399567
46CSNK1A1L1.29118379
47TSSK61.28904121
48DYRK21.28742202
49BRAF1.21822957
50ARAF1.21818828
51MAP3K31.18881985
52MAP3K111.16380092
53MAPK131.11745233
54SIK31.11345001
55PLK11.10924505
56CCNB11.07925387
57STK38L1.07189916
58MAP4K11.05281742
59FRK1.04454134
60AURKB1.00197322
61MST40.99097283
62MINK10.98942098
63TEC0.98933188
64MAP2K30.97960674
65MARK10.97300908
66TAOK30.94371462
67TLK10.93777961
68PBK0.93089314
69GRK10.92928732
70TAF10.91859833
71MAP3K120.91338570
72NLK0.91008368
73MAPKAPK30.90407768
74NEK90.86256706
75CDK80.84541777
76ABL20.83870867
77AURKA0.82705348
78NEK10.82380177
79OXSR10.82070784
80TYK20.81004218
81EPHA40.79973978
82PNCK0.79844452
83MAP2K20.79765824
84PIM10.79610910
85BRSK10.79272241
86CDK190.78707762
87EPHA20.78202077
88PDK40.77726409
89PDK30.77726409
90RPS6KB20.73399787
91PIK3CG0.73343319
92PAK30.71501166
93INSRR0.71138623
94CAMKK20.70496379
95PLK30.70069626
96PRKCG0.69916870
97TBK10.68761945
98TXK0.67106995
99CDK70.66707731
100AKT30.66273812
101ZAK0.65196585
102NUAK10.64771699
103PRKCE0.64439640
104LIMK10.62336602
105IRAK10.62212748
106JAK30.60822288
107TTK0.60375937
108CSNK2A10.59365766
109UHMK10.58765214
110ATM0.58473966
111MAP2K60.56645055
112CSNK2A20.56300434
113STK390.56238137
114MAP3K80.55940653
115ADRBK20.55787855
116LRRK20.55644207
117BTK0.53850206
118CDK40.51471169
119CDK30.51358481
120FER0.50597699
121PDK20.50420679
122PRKCI0.50121683
123ATR0.49803270
124FGFR20.48770420
125FGFR10.47326182
126PAK40.45713361
127CDK140.45003040
128IKBKB0.44946060
129EIF2AK20.44809533
130CDK180.44382637
131BLK0.41152537
132CHEK20.40107977
133ERBB40.39932253
134CSNK1E0.39748559
135MAP3K50.39659754
136BRD40.38644731
137RPS6KA50.38147454
138CAMK2A0.37439852
139CHEK10.36936332
140PINK10.36219499
141DYRK1A0.35852912
142MAP2K40.35571735
143CSNK1A10.35486915
144PAK10.35369389
145SYK0.34989358
146KSR10.33770875
147IKBKE0.33697914
148DAPK10.32954745
149CDK150.31301598
150TAOK20.30920935
151TGFBR10.30782369
152LYN0.30035159
153ALK0.29752039
154GRK60.26584682
155STK30.25396541
156ILK0.25179600

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.28965740
2Ribosome_Homo sapiens_hsa030104.10887537
3* Protein export_Homo sapiens_hsa030603.93717208
4RNA polymerase_Homo sapiens_hsa030203.28762147
5DNA replication_Homo sapiens_hsa030303.01243443
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.77086950
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.72987788
8Folate biosynthesis_Homo sapiens_hsa007902.71040574
9Pyrimidine metabolism_Homo sapiens_hsa002402.57743664
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.28665762
11Steroid biosynthesis_Homo sapiens_hsa001002.11064708
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.10943934
13Mismatch repair_Homo sapiens_hsa034302.10906617
14RNA transport_Homo sapiens_hsa030132.04098075
15Spliceosome_Homo sapiens_hsa030402.02751576
16Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.84917804
17Nucleotide excision repair_Homo sapiens_hsa034201.84298248
18Vitamin B6 metabolism_Homo sapiens_hsa007501.83264661
19Base excision repair_Homo sapiens_hsa034101.81056187
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.79084112
21Homologous recombination_Homo sapiens_hsa034401.77937527
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66806636
23Fatty acid elongation_Homo sapiens_hsa000621.66460880
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.60602342
25Sulfur relay system_Homo sapiens_hsa041221.59454176
26Butanoate metabolism_Homo sapiens_hsa006501.58400999
27Basal transcription factors_Homo sapiens_hsa030221.55351702
28Oxidative phosphorylation_Homo sapiens_hsa001901.51229843
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45910844
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.42131679
31One carbon pool by folate_Homo sapiens_hsa006701.42060584
32Selenocompound metabolism_Homo sapiens_hsa004501.40214825
33Purine metabolism_Homo sapiens_hsa002301.36338355
34Pentose phosphate pathway_Homo sapiens_hsa000301.36298903
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35856710
36Parkinsons disease_Homo sapiens_hsa050121.35521556
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.34670752
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.34157393
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.32471152
40Cell cycle_Homo sapiens_hsa041101.29361328
41Regulation of autophagy_Homo sapiens_hsa041401.28629010
42N-Glycan biosynthesis_Homo sapiens_hsa005101.20969527
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.15136780
44Sulfur metabolism_Homo sapiens_hsa009201.13886467
45Antigen processing and presentation_Homo sapiens_hsa046121.13140736
46Legionellosis_Homo sapiens_hsa051341.13034901
47RNA degradation_Homo sapiens_hsa030181.11477746
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10166292
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09726911
50Huntingtons disease_Homo sapiens_hsa050161.07719138
51Oocyte meiosis_Homo sapiens_hsa041141.01689004
52p53 signaling pathway_Homo sapiens_hsa041151.00557346
53Nicotine addiction_Homo sapiens_hsa050330.99974724
54Phototransduction_Homo sapiens_hsa047440.98310572
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97340858
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95539109
57Other glycan degradation_Homo sapiens_hsa005110.94765460
58Fanconi anemia pathway_Homo sapiens_hsa034600.93088486
59Epstein-Barr virus infection_Homo sapiens_hsa051690.91397055
60Biosynthesis of amino acids_Homo sapiens_hsa012300.84192381
61Fatty acid metabolism_Homo sapiens_hsa012120.81768196
62Fat digestion and absorption_Homo sapiens_hsa049750.81204598
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79810759
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.78928939
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76250094
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74583741
67beta-Alanine metabolism_Homo sapiens_hsa004100.74435338
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74095735
69Glutathione metabolism_Homo sapiens_hsa004800.73878110
70Galactose metabolism_Homo sapiens_hsa000520.72551397
71Metabolic pathways_Homo sapiens_hsa011000.67808422
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66797012
73Carbon metabolism_Homo sapiens_hsa012000.65217691
74Fructose and mannose metabolism_Homo sapiens_hsa000510.64738796
75Alzheimers disease_Homo sapiens_hsa050100.64561246
76Vibrio cholerae infection_Homo sapiens_hsa051100.60371209
77Fatty acid degradation_Homo sapiens_hsa000710.59726880
78Cardiac muscle contraction_Homo sapiens_hsa042600.59304497
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58782758
80Peroxisome_Homo sapiens_hsa041460.56954803
81Caffeine metabolism_Homo sapiens_hsa002320.56754306
82Primary immunodeficiency_Homo sapiens_hsa053400.55789466
83Herpes simplex infection_Homo sapiens_hsa051680.54188073
84Collecting duct acid secretion_Homo sapiens_hsa049660.53959904
85Non-homologous end-joining_Homo sapiens_hsa034500.53599116
86Nitrogen metabolism_Homo sapiens_hsa009100.53313250
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.53276843
88Pancreatic secretion_Homo sapiens_hsa049720.52141144
89GABAergic synapse_Homo sapiens_hsa047270.50748528
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50408450
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.49126524
92Arginine and proline metabolism_Homo sapiens_hsa003300.48999478
93Pyruvate metabolism_Homo sapiens_hsa006200.48771897
94Hedgehog signaling pathway_Homo sapiens_hsa043400.48357516
95Vitamin digestion and absorption_Homo sapiens_hsa049770.47797168
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47588607
97Retinol metabolism_Homo sapiens_hsa008300.47427755
98Taste transduction_Homo sapiens_hsa047420.46463377
99mRNA surveillance pathway_Homo sapiens_hsa030150.46340708
100Lysosome_Homo sapiens_hsa041420.45611362
101Renin-angiotensin system_Homo sapiens_hsa046140.45273997
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45245833
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44988804
104Basal cell carcinoma_Homo sapiens_hsa052170.44075362
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43329616
106Hippo signaling pathway_Homo sapiens_hsa043900.40783492
107Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39837717
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39086409
109Chemical carcinogenesis_Homo sapiens_hsa052040.37970099
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36764014
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36720373
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36340581
113Linoleic acid metabolism_Homo sapiens_hsa005910.35899680
114Type I diabetes mellitus_Homo sapiens_hsa049400.35492951
115Ether lipid metabolism_Homo sapiens_hsa005650.35185442
116Systemic lupus erythematosus_Homo sapiens_hsa053220.33675076
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32330218
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32076577
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32000226
120TGF-beta signaling pathway_Homo sapiens_hsa043500.31899068
121Thyroid cancer_Homo sapiens_hsa052160.31610518
122Arachidonic acid metabolism_Homo sapiens_hsa005900.31186541
123Circadian rhythm_Homo sapiens_hsa047100.30790415
124Dopaminergic synapse_Homo sapiens_hsa047280.29615935
125Glycosaminoglycan degradation_Homo sapiens_hsa005310.29371982
126Allograft rejection_Homo sapiens_hsa053300.29078466
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28127226
128Wnt signaling pathway_Homo sapiens_hsa043100.28010793
129Asthma_Homo sapiens_hsa053100.27967383
130Measles_Homo sapiens_hsa051620.27525893
131Propanoate metabolism_Homo sapiens_hsa006400.27237853
132Olfactory transduction_Homo sapiens_hsa047400.25889449
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22543690
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22076346
135Protein digestion and absorption_Homo sapiens_hsa049740.21255179
136Graft-versus-host disease_Homo sapiens_hsa053320.20835862
137NF-kappa B signaling pathway_Homo sapiens_hsa040640.19920928
138Tryptophan metabolism_Homo sapiens_hsa003800.19747537
139Shigellosis_Homo sapiens_hsa051310.19742665
140Starch and sucrose metabolism_Homo sapiens_hsa005000.19532001

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